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346 results on '"Deterding K"'

1. Long-term persistence of HCV resistance-associated substitutions after DAA treatment failure

Author

Balavoine, J., Giostra, E., Berning, M., Hampe, J., Canbay, A., Steckstor, W., Schmiegel, W., Brockmeyer, N.H., De Gottardi, A., Rauch, A., Semmo, N., Fischer, J., Gress, M., Heinzow, H., Hilgard, G., Schmidt, H., Herrmann, A., Stallmach, A., Hoffmann, D., Protzer, U., Klinker, H., Schulze, P., Kodal, A., Kremer, A., Siebler, J., Löbermann, M., Götze, T., Weigt, J., Lohse, A., Von Felden, J., Jordan, S., Lange, C.M., Zachoval, R., Mayerle, J., Maieron, A., Moradpour, D., Chave, J.-P., Moreno, C., Muche, M., Epple, H.-J., Müller-Schilling, M., Kocheise, F., Müllhaupt, B., Port, K., Deterding, K., Wedemeyer, H., Cornberg, M., Manns, M., Reinhardt, L., Ellenrieder, V., Rissland, J., Semela, D., Spengler, U., Rockstroh, J., Roeb, E., Sprinzl, M., Galle, P., Stauber, R., Stremmel, W., Strey, B., Thimme, R., Boettler, T., Tacke, F., Teufel, A., Vogelmann, R., Ebert, M., Tomasiewicz, K., Trautwein, C., Koenen, T., Weber, T., Wietzke-Braun, P., Günther, R., Zizer, E., Backhus, J., Seufferlein, T., Angeli, W., Beckebaum, S., Doberauer, C., Durmashkina, E., Hackelsberger, A., Erhardt, A., Garrido-Lüneburg, A., Gattringer, H., Genné, D., Gschwantler, M., Gundling, F., Hametner, S., Schöfl, R., Hartmann, C., Heyer, T., Hirschi, C., Jussios, A., Kanzler, S., Kordecki, N., Kraus, M., Kullig, U., Wollschläger, S., Magenta, L., Terziroli Beretta-Piccoli, B., Menges, M., Mohr, L., Muehlenberg, K., Niederau, C., Paulweber, B., Petrides, A., Pinkernell, M., Piso, R., Rambach, W., Reiser, M., Riecken, B., Rieke, A., Roth, J., Schelling, M., Schlee, P., Schneider, A., Scholz, D., Schott, E., Schuchmann, M., Schulten-Baumer, U., Seelhoff, A., Stich, A., Stickel, F., Ungemach, J., Walter, E., Weber, A., Winzer, T., Abels, W., Adler, M., Audebert, F., Baermann, C., Bästlein, E., Barth, R., Barthel, K., Becker, W., Behrends, J., Benninger, J., Berger, F., Berzow, D., Beyer, T., Bierbaum, M., Blaukat, O., Bodtländer, A., Böhm, G., Börner, N., Bohr, U., Bokemeyer, B., Bruch, H.R., Bucholz, D., Burkhard, O., Busch, N., Chirca, C., Delker, R., Diedrich, J., Frank, M., Diehl, M., Dienethal, A., Dietel, P., Dikopoulos, N., Dreck, M., Dreher, F., Drude, L., Ende, K., Ehrle, U., Baumgartl, K., Emke, F., Glosemeyer, R., Felten, G., Hüppe, D., Fischer, U., Frederking, D., Frick, B., Friese, G., Gantke, B., Geyer, P., Schwind, H.R., Glas, M., Glaunsinger, T., Goebel, F., Göbel, U., Görlitz, B., Graf, R., Gruber, H., Härter, G., Herder, M., Heuchel, T., Heuer, S., Höffl, K.-H., Hörster, H., Sonne, J.-U., Hofmann, W.P., Holst, F., Hunstiger, M., Hurst, A., Jägel-Guedes, E., John, C., Jung, M., Kallinowski, B., Kapzan, B., Kerzel, W., Khaykin, P., Klarhof, M., Klüppelberg, U., Wolfratshausen, Klugewitz, K., Knapp, B., Knevels, U., Kochsiek, T., Körfer, A., Köster, A., Kuhn, M., Langekamp, A., Künzig, B., Link, R., Littman, M., Löhr, H., Lutz, T., Knecht, G., Lutz, U., Mainz, D., Mahle, I., Maurer, P., Mayer, C., Meister, V., Möller, H., Heyne, R., Moritzen, D., Mroß, M., Mundlos, M., Naumann, U., Nehls, O., Ningel, K.R., Oelmann, A., Olejnik, H., Gadow, K., Pascher, E., Petersen, J., Philipp, A., Pichler, M., Polzien, F., Raddant, R., Riedel, M., Rietzler, S., Rössle, M., Rufle, W., Rump, A., Schewe, C., Hoffmann, C., Schleehauf, D., Schmidt, W., Schmidt-Heinevetter, G., Schmidtler-von Fabris, J., Schneider, L., Schober, A., Niehaus-Hahn, S., Schwenzer, J., Seegers, B., Seidel, T., Seitel, G., Sick, C., Simon, K., Stähler, D., Stenschke, F., Steffens, H., Stein, K., Steinmüller, M., Sternfeld, T., Svensson, K., Tacke, W., Teuber, G., Teubner, K., Thieringer, J., Tomesch, A., Trappe, U., Ullrich, J., Urban, G., Usadel, S., Von Lucadou, A., Weinberger, F., Werheid-Dobers, M., Werner, P., Winter, T., Zehnter, E., Zipf, A., Dietz, Julia, Müllhaupt, Beat, Buggisch, Peter, Graf, Christiana, Peiffer, Kai-Henrik, Matschenz, Katrin, Schattenberg, Jörn M., Antoni, Christoph, Mauss, Stefan, Niederau, Claus, Discher, Thomas, Trauth, Janina, Dultz, Georg, Schulze zur Wiesch, Julian, Piecha, Felix, Klinker, Hartwig, Müller, Tobias, Berg, Thomas, Neumann-Haefelin, Christoph, Berg, Christoph P., Zeuzem, Stefan, and Sarrazin, Christoph

Published
2023
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2. Efficacy of Retreatment After Failed Direct-acting Antiviral Therapy in Patients With HCV Genotype 1–3 Infections

Author

Balavoine, J., Giostra, E., Berning, M., Hampe, J., De Gottardi, A., Rauch, A., Semmo, N., Discher, T., Trauth, J., Fischer, J., Gress, M., Günther, R., Heinzow, H., Schmidt, J., Herrmann, A., Stallmach, A., Hilgard, G., Deterding, K., Lange, C.M., Ciesek, S., Wedemeyer, H., Hoffmann, D., Klinker, H., Schulze, P., Kocheise, F., Müller-Schilling, M., Kodal, A., Kremer, A., Ganslmayer, M., Siebler, J., Lammert, F., Rissland, J., Löbermann, M., Götze, T., Canbay, A., Lohse, A., von Felden, J., Jordan, S., Maieron, A., Moradpour, D., Chave, J.-P., Moreno, C., Müller, T., Muche, M., Epple, H.-J., Port, K., von Hahn, T., Cornberg, M., Manns, M., Reinhardt, L., Ellenrieder, V., Rockstroh, J., Schattenberg, J., Sprinzl, M., Galle, P., Roeb, E., Steckstor, M., Schmiegel, W., Brockmeyer, N.H., Seufferlein, T., Stremmel, W., Strey, B., Thimme, R., Teufel, A., Vogelmann, R., Ebert, M., Tomasiewicz, K., Trautwein, C., Tacke, F., Koenen, T., Weber, T., Zachoval, R., Mayerle, J., Raziorrouh, B., Angeli, W., Beckebaum, S., Doberauer, C., Durmashkina, E., Hackelsberger, A., Erhardt, A., Garrido-Lüneburg, A., Gattringer, H., Genné, D., Gschwantler, M., Gundling, F., Hametner, S., Schöfl, R., Hartmann, C., Heyer, T., Hirschi, C., Jussios, A., Kanzler, S., Kordecki, N., Kraus, M., Kullig, U., Wollschläger, S., Magenta, L., Beretta-Piccoli, B. Terziroli, Menges, M., Mohr, L., Muehlenberg, K., Niederau, C., Paulweber, B., Petrides, A., Pinkernell, M., Piso, R., Rambach, W., Reiser, M., Riecken, B., Rieke, A., Roth, J., Schelling, M., Schlee, P., Schneider, A., Scholz, D., Schott, E., Schuchmann, M., Schulten-Baumer, U., Seelhoff, A., Stich, A., Stickel, F., Ungemach, J., Walter, E., Weber, A., Winzer, T., Abels, W., Adler, M., Audebert, F., Baermann, C., Bästlein, E., Barth, R., Barthel, K., Becker, W., Behrends, J., Benninger, J., Berger, F., Berzow, D., Beyer, T., Bierbaum, M., Blaukat, O., Bodtländer, A., Böhm, G., Börner, N., Bohr, U., Bokemeyer, B., Bruch, H.R., Bucholz, D., Burkhard, O., Busch, N., Chirca, C., Delker, R., Diedrich, J., Frank, M., Diehl, M., Dienethal, A., Dietel, P., Dikopoulos, N., Dreck, M., Dreher, F., Drude, L., Ende, K., Ehrle, U., Baumgartl, K., Emke, F., Glosemeyer, R., Felten, G., Hüppe, D., Fischer, U., Frederking, D., Frick, B., Friese, G., Gantke, B., Geyer, P., Schwind, H.R., Glas, M., Glaunsinger, T., Goebel, F., Göbel, U., Görlitz, B., Graf, R., Gruber, H., Härter, G., Herder, M., Heuchel, T., Heuer, S., Höffl, K.-H., Hörster, H., Sonne, J.-U., Hofmann, W.P., Holst, F., Hunstiger, M., Hurst, A., Jägel-Guedes, E., John, C., Jung, M., Kallinowski, B., Kapzan, B., Kerzel, W., Khaykin, P., Klarhof, M., Klüppelberg, U., Klugewitz, K., Knapp, B., Knevels, U., Kochsiek, T., Körfer, A., Köster, A., Kuhn, M., Langekamp, A., Künzig, B., Link, R., Littman, M., Löhr, H., Lutz, T., Knecht, G., Lutz, U., Mainz, D., Mahle, I., Maurer, P., Mayer, C., Meister, V., Möller, H., Heyne, R., Moritzen, D., Mroß, M., Mundlos, M., Naumann, U., Nehls, O., Ningel, K.&R., Oelmann, A., Olejnik, H., Gadow, K., Pascher, E., Petersen, J., Philipp, A., Pichler, M., Polzien, F., Raddant, R., Riedel, M., Rietzler, S., Rössle, M., Rufle, W., Rump, A., Schewe, C., Hoffmann, C., Schleehauf, D., Schmidt, K.J., Schmidt, W., Schmidt-Heinevetter, G., Schmidtler-von Fabris, J., Schnaitmann, E., Schneider, L., Schober, A., Niehaus-Hahn, S., Schwenzer, J., Seidel, T., Seitel, G., Sick, C., Simon, K.G., Stähler, D., Stenschke, F., Steffens, H., Stein, K., Steinmüller, M., Sternfeld, T., Svensson, K., Tacke, W., Teuber, G., Teubner, K., Thieringer, J., Tomesch, A., Trappe, U., Ullrich, J., Urban, G., Usadel, S., von Lucadou, A., Weinberger, F., Werheid-Dobers, M., Werner, P., Winter, T., Zehnter, E., Zipf, A., Dietz, Julia, Spengler, Ulrich, Müllhaupt, Beat, Schulze zur Wiesch, Julian, Piecha, Felix, Mauss, Stefan, Seegers, Barbara, Hinrichsen, Holger, Antoni, Christoph, Wietzke-Braun, Perdita, Peiffer, Kai-Henrik, Berger, Annemarie, Matschenz, Katrin, Buggisch, Peter, Backhus, Johanna, Zizer, Eugen, Boettler, Tobias, Neumann-Haefelin, Christoph, Semela, David, Stauber, Rudolf, Berg, Thomas, Berg, Christoph, Zeuzem, Stefan, Vermehren, Johannes, and Sarrazin, Christoph

Published
2021
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4. Die Anlage eines transjugulären intrahepatischen portosystemischen Shunts bei Patient:innen mit dekompensierter Leberzirrhose ist mit einer signifikanten Verbesserung der Lebensqualität assoziiert

Author

Wagner, L. S., additional, Schneider, H., additional, Tiede, A., additional, Mauz, J. B., additional, Stockhoff, L., additional, Ehrenbauer, A. F., additional, Witt, J., additional, Keimburg, S. A., additional, Deterding, K., additional, Wedemeyer, H., additional, Markova, A. A., additional, and Maasoumy, B., additional

Published
2023
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6. Real‐world experience with the all‐oral, interferon‐free regimen of ombitasvir/paritaprevir/ritonavir and dasabuvir for the treatment of chronic hepatitis C virus infection in the German Hepatitis C Registry

Author

Welzel, T. M., Hinrichsen, H., Sarrazin, C., Buggisch, P., Baumgarten, A., Christensen, S., Berg, T., Mauss, S., Teuber, G., Stein, K., Deterding, K., van Bömmel, F., Heyne, R., John, C., Zimmermann, T., Lutz, T., Schott, E., Hettinger, J., Kleine, H., König, B., Hüppe, D., and Wedemeyer, H.

Published
2017
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16. Efficacy of Retreatment After Failed Direct-acting Antiviral Therapy in Patients With HCV Genotype 1-3 Infections

Author

Dietz, Julia, Spengler, Ulrich, Mullhaupt, Beat, zur Wiesch, Julian Schulze, Piecha, Felix, Mauss, Stefan, Seegers, Barbara, Hinrichsen, Holger, Antoni, Christoph, Wietzke-Braun, Perdita, Peiffer, Kai-Henrik, Berger, Annemarie, Matschenz, Katrin, Buggisch, Peter, Backhus, Johanna, Zizer, Eugen, Boettler, Tobias, Neumann-Haefelin, Christoph, Semela, David, Stauber, Rudolf, Berg, Thomas, Berg, Christoph, Zeuzem, Stefan, Vermehren, Johannes, Sarrazin, Christoph, Balavoine, J., Giostra, E., Berning, M., Hampe, J., De Gottardi, A., Rauch, A., Semmo, N., Discher, T., Trauth, J., Fischer, J., Gress, M., Guenther, R., Heinzow, H., Schmidt, J., Herrmann, A., Stallmach, A., Hilgard, G., Deterding, K., Lange, C. M., Ciesek, S., Wedemeyer, H., Hoffmann, D., Klinker, H., Schulze, P., Kocheise, F., Mueller-Schilling, M., Kodal, A., Kremer, A., Ganslmayer, M., Siebler, J., Lammert, F., Rissland, J., Loebermann, M., Goetze, T., Canbay, A., Lohse, A., von Felden, J., Jordan, S., Maieron, A., Moradpour, D., Chave, J. -P., Moreno, C., Mueller, T., Muche, M., Epple, H. -J., Port, K., von Hahn, T., Cornberg, M., Manns, M., Reinhardt, L., Ellenrieder, V., Rockstroh, J., Schattenberg, J., Sprinzl, M., Galle, P., Roeb, E., Steckstor, M., Schmiegel, W., Brockmeyer, N. H., Seufferlein, T., Stremmel, W., Strey, B., Thimme, R., Teufel, A., Vogelmann, R., Ebert, M., Tomasiewicz, K., Trautwein, C., Tacke, F., Koenen, T., Weber, T., Zachoval, R., Mayerle, J., Raziorrouh, B., Angeli, W., Beckebaum, S., Doberauer, C., Durmashkina, E., Hackelsberger, A., Erhardt, A., Garrido-Luneburg, A., Gattringer, H., Genne, D., Gschwantler, M., Gundling, F., Hametner, S., Schofl, R., Hartmann, C., Heyer, T., Hirschi, C., Jussios, A., Kanzler, S., Kordecki, N., Kraus, M., Kullig, U., Wollschlager, S., Magenta, L., Beretta-Piccoli, B. Terziroli, Menges, M., Mohr, L., Muehlenberg, K., Niederau, C., Paulweber, B., Petrides, A., Pinkernell, M., Piso, R., Rambach, W., Reiser, M., Riecken, B., Rieke, A., Roth, J., Schelling, M., Schlee, P., Schneider, A., Scholz, D., Schott, E., Schuchmann, M., Schulten-Baumer, U., Seelhoff, A., Stich, A., Stickel, F., Ungemach, J., Walter, E., Weber, A., Winzer, T., Abels, W., Adler, M., Baermann, C., Bastlein, E., Barth, R., Barthel, K., Becker, W., Behrends, J., Benninger, J., Berger, F., Berzow, D., Beyer, T., Bierbaum, M., Blaukat, O., Bodtlander, A., Bohm, G., Borner, N., Bohr, U., Bokemeyer, B., Bruch, H. R., Bucholz, D., Burkhard, O., Busch, N., Chirca, C., Delker, R., Diedrich, J., Frank, M., Diehl, M., Dienethal, A., Dietel, P., Dikopoulos, N., Dreck, M., Dreher, F., Drude, L., Ende, K., Ehrle, U., Baumgartl, K., Emke, F., Glosemeyer, R., Felten, G., Huppe, D., Fischer, U., Frederking, D., Frick, B., Friese, G., Gantke, B., Geyer, P., Schwind, H. R., Glas, M., Glaunsinger, T., Goebel, F., Gobel, U., Gorlitz, B., Graf, R., Gruber, H., Harter, G., Herder, M., Heuchel, T., Heuer, S., Hoffl, K. -H., Horster, H., Sonne, J. -U., Hofmann, W. P., Holst, F., Hunstiger, M., Hurst, A., Jagel-Guedes, E., John, C., Jung, M., Kallinowski, B., Kapzan, B., Kerzel, W., Khaykin, P., Klarhof, M., Kluppelberg, U., Klugewitz, K., Knapp, B., Knevels, U., Kochsiek, T., Korfer, A., Koster, A., Kuhn, M., Langekamp, A., Kunzig, B., Link, R., Littman, M., Lohr, H., Lutz, T., Knecht, G., Lutz, U., Mainz, D., Mahle, I., Maurer, P., Mayer, C., Meister, V., Moller, H., Heyne, R., Moritzen, D., Mross, M., Mundlos, M., Naumann, U., Nehls, O., Ningel, R., Oelmann, A., Olejnik, H., Gadow, K., Pascher, E., Petersen, J., Philipp, A., Pichler, M., Polzien, F., Raddant, R., Riedel, M., Rietzler, S., Rossle, M., Rufle, W., Rump, A., Schewe, C., Hoffmann, C., Schleehauf, D., Schmidt, K. J., Schmidt, W., Schmidt-Heinevetter, G., Schmidtler-von Fabris, J., Schnaitmann, E., Schneider, L., Schober, A., Niehaus-Hahn, S., Schwenzer, J., Seidel, T., Seitel, G., Sick, C., Simon, K. G., Stahler, D., Stenschke, F., Steffens, H., Stein, K., Steinmuller, M., Sternfeld, T., Svensson, K., Tacke, W., Teuber, G., Teubner, K., Thieringer, J., Tomesch, A., Trappe, U., Ullrich, J., Urban, G., Usadel, S., von Lucadou, A., Weinberger, F., Werheid-Dobers, M., Werner, P., Winter, T., Zehnter, E., Zipf, A., Dietz, Julia, Spengler, Ulrich, Mullhaupt, Beat, zur Wiesch, Julian Schulze, Piecha, Felix, Mauss, Stefan, Seegers, Barbara, Hinrichsen, Holger, Antoni, Christoph, Wietzke-Braun, Perdita, Peiffer, Kai-Henrik, Berger, Annemarie, Matschenz, Katrin, Buggisch, Peter, Backhus, Johanna, Zizer, Eugen, Boettler, Tobias, Neumann-Haefelin, Christoph, Semela, David, Stauber, Rudolf, Berg, Thomas, Berg, Christoph, Zeuzem, Stefan, Vermehren, Johannes, Sarrazin, Christoph, Balavoine, J., Giostra, E., Berning, M., Hampe, J., De Gottardi, A., Rauch, A., Semmo, N., Discher, T., Trauth, J., Fischer, J., Gress, M., Guenther, R., Heinzow, H., Schmidt, J., Herrmann, A., Stallmach, A., Hilgard, G., Deterding, K., Lange, C. M., Ciesek, S., Wedemeyer, H., Hoffmann, D., Klinker, H., Schulze, P., Kocheise, F., Mueller-Schilling, M., Kodal, A., Kremer, A., Ganslmayer, M., Siebler, J., Lammert, F., Rissland, J., Loebermann, M., Goetze, T., Canbay, A., Lohse, A., von Felden, J., Jordan, S., Maieron, A., Moradpour, D., Chave, J. -P., Moreno, C., Mueller, T., Muche, M., Epple, H. -J., Port, K., von Hahn, T., Cornberg, M., Manns, M., Reinhardt, L., Ellenrieder, V., Rockstroh, J., Schattenberg, J., Sprinzl, M., Galle, P., Roeb, E., Steckstor, M., Schmiegel, W., Brockmeyer, N. H., Seufferlein, T., Stremmel, W., Strey, B., Thimme, R., Teufel, A., Vogelmann, R., Ebert, M., Tomasiewicz, K., Trautwein, C., Tacke, F., Koenen, T., Weber, T., Zachoval, R., Mayerle, J., Raziorrouh, B., Angeli, W., Beckebaum, S., Doberauer, C., Durmashkina, E., Hackelsberger, A., Erhardt, A., Garrido-Luneburg, A., Gattringer, H., Genne, D., Gschwantler, M., Gundling, F., Hametner, S., Schofl, R., Hartmann, C., Heyer, T., Hirschi, C., Jussios, A., Kanzler, S., Kordecki, N., Kraus, M., Kullig, U., Wollschlager, S., Magenta, L., Beretta-Piccoli, B. Terziroli, Menges, M., Mohr, L., Muehlenberg, K., Niederau, C., Paulweber, B., Petrides, A., Pinkernell, M., Piso, R., Rambach, W., Reiser, M., Riecken, B., Rieke, A., Roth, J., Schelling, M., Schlee, P., Schneider, A., Scholz, D., Schott, E., Schuchmann, M., Schulten-Baumer, U., Seelhoff, A., Stich, A., Stickel, F., Ungemach, J., Walter, E., Weber, A., Winzer, T., Abels, W., Adler, M., Baermann, C., Bastlein, E., Barth, R., Barthel, K., Becker, W., Behrends, J., Benninger, J., Berger, F., Berzow, D., Beyer, T., Bierbaum, M., Blaukat, O., Bodtlander, A., Bohm, G., Borner, N., Bohr, U., Bokemeyer, B., Bruch, H. R., Bucholz, D., Burkhard, O., Busch, N., Chirca, C., Delker, R., Diedrich, J., Frank, M., Diehl, M., Dienethal, A., Dietel, P., Dikopoulos, N., Dreck, M., Dreher, F., Drude, L., Ende, K., Ehrle, U., Baumgartl, K., Emke, F., Glosemeyer, R., Felten, G., Huppe, D., Fischer, U., Frederking, D., Frick, B., Friese, G., Gantke, B., Geyer, P., Schwind, H. R., Glas, M., Glaunsinger, T., Goebel, F., Gobel, U., Gorlitz, B., Graf, R., Gruber, H., Harter, G., Herder, M., Heuchel, T., Heuer, S., Hoffl, K. -H., Horster, H., Sonne, J. -U., Hofmann, W. P., Holst, F., Hunstiger, M., Hurst, A., Jagel-Guedes, E., John, C., Jung, M., Kallinowski, B., Kapzan, B., Kerzel, W., Khaykin, P., Klarhof, M., Kluppelberg, U., Klugewitz, K., Knapp, B., Knevels, U., Kochsiek, T., Korfer, A., Koster, A., Kuhn, M., Langekamp, A., Kunzig, B., Link, R., Littman, M., Lohr, H., Lutz, T., Knecht, G., Lutz, U., Mainz, D., Mahle, I., Maurer, P., Mayer, C., Meister, V., Moller, H., Heyne, R., Moritzen, D., Mross, M., Mundlos, M., Naumann, U., Nehls, O., Ningel, R., Oelmann, A., Olejnik, H., Gadow, K., Pascher, E., Petersen, J., Philipp, A., Pichler, M., Polzien, F., Raddant, R., Riedel, M., Rietzler, S., Rossle, M., Rufle, W., Rump, A., Schewe, C., Hoffmann, C., Schleehauf, D., Schmidt, K. J., Schmidt, W., Schmidt-Heinevetter, G., Schmidtler-von Fabris, J., Schnaitmann, E., Schneider, L., Schober, A., Niehaus-Hahn, S., Schwenzer, J., Seidel, T., Seitel, G., Sick, C., Simon, K. G., Stahler, D., Stenschke, F., Steffens, H., Stein, K., Steinmuller, M., Sternfeld, T., Svensson, K., Tacke, W., Teuber, G., Teubner, K., Thieringer, J., Tomesch, A., Trappe, U., Ullrich, J., Urban, G., Usadel, S., von Lucadou, A., Weinberger, F., Werheid-Dobers, M., Werner, P., Winter, T., Zehnter, E., and Zipf, A.

Published
2021

17. HBcrAg levels are associated with virological response to treatment with interferon in patients with hepatitis delta

Author

Yurdaydın, Cihan (ORCID 0000-0002-5419-7158 & YÖK ID 189330), Sandmann, L.; Deterding, K.; Heidrich, B.; Hardtke, S.; Lehmann, P.; Bremer, B.; Manns, M. P.; Cornberg, M.; Wedemeyer, H.; Maasoumy, B.; HIDIT-II Study Group, School of Medicine, Yurdaydın, Cihan (ORCID 0000-0002-5419-7158 & YÖK ID 189330), Sandmann, L.; Deterding, K.; Heidrich, B.; Hardtke, S.; Lehmann, P.; Bremer, B.; Manns, M. P.; Cornberg, M.; Wedemeyer, H.; Maasoumy, B.; HIDIT-II Study Group, and School of Medicine

Abstract

Standard treatment of hepatitis delta virus (HDV) infection remains pegylated-interferon alfa (peg-IFN?) in most centers, which is not only associated with rather low efficacy but several adverse events. Hepatitis B core-related antigen (HBcrAg) is linked to intrahepatic covalently closed circular DNA levels and has previously been suggested as response predictor in IFN-based treatment of hepatitis B virus (HBV) mono-infection. This study aimed to investigate the value of HBcrAg in the management of patients with HBV/HDV co-infection undergoing peg-IFN? treatment. The Hep-Net-International-Delta-Hepatitis-Intervention Trial-2 study included 120 patients co-infected with HBV/HDV. Patients were treated for 96 weeks with peg-IFN? and either tenofovir or placebo. Ninety-nine patients with HDV-RNA results 24 weeks after end of treatment (FU24) were included in this analysis, of whom 32 patients (32.3%) had undetectable HDV RNA at FU24. HBcrAg was measured at baseline, week 12, 24, 48, 96, and FU24. HBcrAg levels showed no significant correlation with HDV RNA but were significantly linked to treatment outcome. HBcrAg levels < 4.5 log IU/mL at baseline, week 24, and week 48 had high negative predictive value (NPV) for achieving undetectable HDV RNA at FU24 (81.8%, 87.1% and 95.0%, respectively). Similarly, HBcrAg levels at week 96 were significantly higher in patients with viral relapse until FU24 (3.0 vs. 3.63 log IU/mL; P = 0.0089). Baseline, week 24, and week 48 HBcrAg levels were also associated with the likelihood of achieving HBsAg level < 100 IU/mL at FU24 (HBcrAg < 3.0 log IU/mL: NPV 91.7%, 90.4% and 92.3%, respectively). Test statistics improved when combining HBcrAg with additional viral and clinical parameters. Conclusion: HBcrAg is linked to treatment response to peg-IFN? in patients with HBV/HDV co-infection and could be a promising marker to determine treatment futility., Fujirebio Europe; Gilead Sciences; F. Hoffmann?La Roche; HepNet Study House

Published
2021

18. Efficacy of Retreatment After Failed Direct-acting Antiviral Therapy in Patients With HCV Genotype 1–3 Infections

Author

Dietz, Julia, primary, Spengler, Ulrich, additional, Müllhaupt, Beat, additional, Schulze zur Wiesch, Julian, additional, Piecha, Felix, additional, Mauss, Stefan, additional, Seegers, Barbara, additional, Hinrichsen, Holger, additional, Antoni, Christoph, additional, Wietzke-Braun, Perdita, additional, Peiffer, Kai-Henrik, additional, Berger, Annemarie, additional, Matschenz, Katrin, additional, Buggisch, Peter, additional, Backhus, Johanna, additional, Zizer, Eugen, additional, Boettler, Tobias, additional, Neumann-Haefelin, Christoph, additional, Semela, David, additional, Stauber, Rudolf, additional, Berg, Thomas, additional, Berg, Christoph, additional, Zeuzem, Stefan, additional, Vermehren, Johannes, additional, Sarrazin, Christoph, additional, Balavoine, J., additional, Giostra, E., additional, Berning, M., additional, Hampe, J., additional, De Gottardi, A., additional, Rauch, A., additional, Semmo, N., additional, Discher, T., additional, Trauth, J., additional, Fischer, J., additional, Gress, M., additional, Günther, R., additional, Heinzow, H., additional, Schmidt, J., additional, Herrmann, A., additional, Stallmach, A., additional, Hilgard, G., additional, Deterding, K., additional, Lange, C.M., additional, Ciesek, S., additional, Wedemeyer, H., additional, Hoffmann, D., additional, Klinker, H., additional, Schulze, P., additional, Kocheise, F., additional, Müller-Schilling, M., additional, Kodal, A., additional, Kremer, A., additional, Ganslmayer, M., additional, Siebler, J., additional, Lammert, F., additional, Rissland, J., additional, Löbermann, M., additional, Götze, T., additional, Canbay, A., additional, Lohse, A., additional, von Felden, J., additional, Jordan, S., additional, Maieron, A., additional, Moradpour, D., additional, Chave, J.-P., additional, Moreno, C., additional, Müller, T., additional, Muche, M., additional, Epple, H.-J., additional, Port, K., additional, von Hahn, T., additional, Cornberg, M., additional, Manns, M., additional, Reinhardt, L., additional, Ellenrieder, V., additional, Rockstroh, J., additional, Schattenberg, J., additional, Sprinzl, M., additional, Galle, P., additional, Roeb, E., additional, Steckstor, M., additional, Schmiegel, W., additional, Brockmeyer, N.H., additional, Seufferlein, T., additional, Stremmel, W., additional, Strey, B., additional, Thimme, R., additional, Teufel, A., additional, Vogelmann, R., additional, Ebert, M., additional, Tomasiewicz, K., additional, Trautwein, C., additional, Tacke, F., additional, Koenen, T., additional, Weber, T., additional, Zachoval, R., additional, Mayerle, J., additional, Raziorrouh, B., additional, Angeli, W., additional, Beckebaum, S., additional, Doberauer, C., additional, Durmashkina, E., additional, Hackelsberger, A., additional, Erhardt, A., additional, Garrido-Lüneburg, A., additional, Gattringer, H., additional, Genné, D., additional, Gschwantler, M., additional, Gundling, F., additional, Hametner, S., additional, Schöfl, R., additional, Hartmann, C., additional, Heyer, T., additional, Hirschi, C., additional, Jussios, A., additional, Kanzler, S., additional, Kordecki, N., additional, Kraus, M., additional, Kullig, U., additional, Wollschläger, S., additional, Magenta, L., additional, Beretta-Piccoli, B. Terziroli, additional, Menges, M., additional, Mohr, L., additional, Muehlenberg, K., additional, Niederau, C., additional, Paulweber, B., additional, Petrides, A., additional, Pinkernell, M., additional, Piso, R., additional, Rambach, W., additional, Reiser, M., additional, Riecken, B., additional, Rieke, A., additional, Roth, J., additional, Schelling, M., additional, Schlee, P., additional, Schneider, A., additional, Scholz, D., additional, Schott, E., additional, Schuchmann, M., additional, Schulten-Baumer, U., additional, Seelhoff, A., additional, Stich, A., additional, Stickel, F., additional, Ungemach, J., additional, Walter, E., additional, Weber, A., additional, Winzer, T., additional, Abels, W., additional, Adler, M., additional, Audebert, F., additional, Baermann, C., additional, Bästlein, E., additional, Barth, R., additional, Barthel, K., additional, Becker, W., additional, Behrends, J., additional, Benninger, J., additional, Berger, F., additional, Berzow, D., additional, Beyer, T., additional, Bierbaum, M., additional, Blaukat, O., additional, Bodtländer, A., additional, Böhm, G., additional, Börner, N., additional, Bohr, U., additional, Bokemeyer, B., additional, Bruch, H.R., additional, Bucholz, D., additional, Burkhard, O., additional, Busch, N., additional, Chirca, C., additional, Delker, R., additional, Diedrich, J., additional, Frank, M., additional, Diehl, M., additional, Dienethal, A., additional, Dietel, P., additional, Dikopoulos, N., additional, Dreck, M., additional, Dreher, F., additional, Drude, L., additional, Ende, K., additional, Ehrle, U., additional, Baumgartl, K., additional, Emke, F., additional, Glosemeyer, R., additional, Felten, G., additional, Hüppe, D., additional, Fischer, U., additional, Frederking, D., additional, Frick, B., additional, Friese, G., additional, Gantke, B., additional, Geyer, P., additional, Schwind, H.R., additional, Glas, M., additional, Glaunsinger, T., additional, Goebel, F., additional, Göbel, U., additional, Görlitz, B., additional, Graf, R., additional, Gruber, H., additional, Härter, G., additional, Herder, M., additional, Heuchel, T., additional, Heuer, S., additional, Höffl, K.-H., additional, Hörster, H., additional, Sonne, J.-U., additional, Hofmann, W.P., additional, Holst, F., additional, Hunstiger, M., additional, Hurst, A., additional, Jägel-Guedes, E., additional, John, C., additional, Jung, M., additional, Kallinowski, B., additional, Kapzan, B., additional, Kerzel, W., additional, Khaykin, P., additional, Klarhof, M., additional, Klüppelberg, U., additional, Klugewitz, K., additional, Knapp, B., additional, Knevels, U., additional, Kochsiek, T., additional, Körfer, A., additional, Köster, A., additional, Kuhn, M., additional, Langekamp, A., additional, Künzig, B., additional, Link, R., additional, Littman, M., additional, Löhr, H., additional, Lutz, T., additional, Knecht, G., additional, Lutz, U., additional, Mainz, D., additional, Mahle, I., additional, Maurer, P., additional, Mayer, C., additional, Meister, V., additional, Möller, H., additional, Heyne, R., additional, Moritzen, D., additional, Mroß, M., additional, Mundlos, M., additional, Naumann, U., additional, Nehls, O., additional, Ningel, K.&R., additional, Oelmann, A., additional, Olejnik, H., additional, Gadow, K., additional, Pascher, E., additional, Petersen, J., additional, Philipp, A., additional, Pichler, M., additional, Polzien, F., additional, Raddant, R., additional, Riedel, M., additional, Rietzler, S., additional, Rössle, M., additional, Rufle, W., additional, Rump, A., additional, Schewe, C., additional, Hoffmann, C., additional, Schleehauf, D., additional, Schmidt, K.J., additional, Schmidt, W., additional, Schmidt-Heinevetter, G., additional, Schmidtler-von Fabris, J., additional, Schnaitmann, E., additional, Schneider, L., additional, Schober, A., additional, Niehaus-Hahn, S., additional, Schwenzer, J., additional, Seidel, T., additional, Seitel, G., additional, Sick, C., additional, Simon, K.G., additional, Stähler, D., additional, Stenschke, F., additional, Steffens, H., additional, Stein, K., additional, Steinmüller, M., additional, Sternfeld, T., additional, Svensson, K., additional, Tacke, W., additional, Teuber, G., additional, Teubner, K., additional, Thieringer, J., additional, Tomesch, A., additional, Trappe, U., additional, Ullrich, J., additional, Urban, G., additional, Usadel, S., additional, von Lucadou, A., additional, Weinberger, F., additional, Werheid-Dobers, M., additional, Werner, P., additional, Winter, T., additional, Zehnter, E., additional, and Zipf, A., additional

Published
2021
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27. Flares during long-term entecavir therapy in chronic hepatitis B

Author

Chi, Heng, Arends, Pauline, Reijnders, Jurriën, Carey, I, Brown, A, Fasano, M, Mutimer, D, Deterding, K, Oo, Y H, Petersen, J, van Bommel, F, de Knegt, Rob, Santantonio, T A, Berg, T, Welzel, TM, Wedemeyer, H, Buti, M, Pradat, P, Zoulim, F, Hansen, Bettina, Janssen, HLA, Forest Research, Alice Holt Lodge, Medcom [Odense], Norwegian Institute for Air Research (NILU), Norwegian University of Science and Technology [Trondheim] (NTNU), Norwegian University of Science and Technology (NTNU), Equipe 16, Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche en Cancérologie de Lyon (CRCL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Gastroenterology & Hepatology

Subjects
Adult, Male, Canada, Hepatitis B virus, Guanine, Biomedical Research, Patients, Drug Resistance, [SDV.CAN]Life Sciences [q-bio]/Cancer, Antiviral Agents, methods, Hepatitis, Hepatitis B, Chronic, Endocrinology, SDG 3 - Good Health and Well-being, Germany, London, Humans, Hepatitis B e Antigens, therapy, Hepatitis B Surface Antigens, Incidence, Gastroenterology, Alanine Transaminase, Middle Aged, Hepatitis B, Liver, Italy, DNA, Viral, Female, France, Biomarkers, Follow-Up Studies
Abstract

International audience; BACKGROUND AND AIM: The incidence and consequences of flares during first-line nucleos(t)ide analogue therapy are largely unknown. We aimed to investigate the incidence and outcome of alanine aminotransferase (ALT) flares during long-term entecavir (ETV) in chronic hepatitis B (CHB). METHODS: CHB patients treated with ETV monotherapy from 11 European centers were studied. Flare was defined as \textgreater 3x increase in ALT compared with baseline or lowest on-treatment level and an absolute ALT \textgreater 3x ULN. Flares were designated as host-induced (preceded by hepatitis B virus (HBV)-DNA decline), virus-induced (HBV-DNA increase), or indeterminate (stable HBV-DNA). RESULTS: Seven hundred and twenty-nine patients were treated with ETV for median of 3.5 years. Thirty patients developed a flare with cumulative incidence of 6.3% at year 5. Baseline hepatitis B e antigen (HBeAg)-positivity (HR 2.84; P = 0.005) and high HBV-DNA (Hazard ratio (HR) 1.30; P = 0.003) predicted flares. There were 12 (40%) host-induced, 7 (23%) virus-induced, and 11 (37%) indeterminate flares. Host-induced flares occurred earlier than virus-induced (median: 15 vs 83 weeks; P = 0.027) or indeterminate flares (15 vs 109 weeks; P = 0.011). Host-induced flares were associated with biochemical remission, and HBeAg (n = 3) and hepatitis B surface antigen (n = 2) seroconversions were exclusively observed among patients with these flares. Virus-induced flares were associated with ETV resistance (n = 2) and non-compliance (n = 1). CONCLUSION: The incidence of ALT flares during ETV was low in this real-life cohort. ETV can be safely continued in patients with host-induced flares. Treatment adherence and drug resistance must be assessed in patients with virus-induced flares

Published
2016
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29. Langzeitnachbeobachtung nach IFN-freier Therapie bei fortgeschrittener HCV-assoziierter Leberzirrhose: Kontinuierliche Verbesserung der Leberfunktionsparameter – Ergebnisse aus dem Deutschen Hepatitis C-Register (DHC-R)

Author

Deterding, K, additional, Mauss, S, additional, Pathil, A, additional, Buggisch, P, additional, Schott, E, additional, Cornberg, M, additional, Zimmermann, T, additional, Simon, KG, additional, Klinker, H, additional, Günther, R, additional, Pfeiffer-Vornkahl, H, additional, Hüppe, D, additional, Sarrazin, C, additional, Zeuzem, S, additional, Manns, MP, additional, Wedemeyer, H, additional, and Berg, T, additional

Published
2017
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32. Interferon-free cure of hepatitis C virus infection does alter the soluble inflammatory milieu which could affect hepatocellular carcinoma surveillance by CD8+ T cells in patients with liver cirrhosis

Author

Sekyere, S.O., primary, Falk, C., additional, Aregay, A., additional, Schlevogt, B., additional, Deterding, K., additional, Manns, M.P., additional, Vogel, A., additional, Wirth, T., additional, Cornberg, M., additional, and Wedemeyer, H., additional

Published
2017
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34. Long-term follow-up after IFN-free therapy of advanced HCV-associated liver cirrhosis: continued improvement of liver function parameters – Results from the German Hepatitis C-Registry (DHC-R)

Author

Deterding, K., primary, Mauss, S., additional, Pathil, A., additional, Buggisch, P., additional, Schott, E., additional, Cornberg, M., additional, Zimmermann, T., additional, Simon, K.-G., additional, Klinker, H., additional, Günther, R., additional, Pfeiffer-Vornkahl, H., additional, Hueppe, D., additional, Sarrazin, C., additional, Zeuzem, S., additional, Manns, M.P., additional, Wedemeyer, H., additional, and Berg, T., additional

Published
2017
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36. Six weeks of Sofosbuvir/Ledipasvir treatment of acute hepatitis C Virus genotype 1 monoinfection: Final results of the German HepNet Acute HCV IV Study

Author

Deterding, K, additional, Spinner, CD, additional, Schott, E, additional, Welzel, TM, additional, Gerken, G, additional, Klinker, H, additional, Spengler, U, additional, Wiegand, J, additional, Schulze zur Wiesch, J, additional, Pathil, A, additional, Cornberg, M, additional, Umgelter, A, additional, Zöllner, C, additional, Zeuzem, S, additional, Papkalla, A, additional, Weber, K, additional, Hardtke, S, additional, der Leyen, H, additional, Koch, A, additional, Witzendorff, D, additional, Manns, MP, additional, and Wedemeyer, H, additional

Published
2016
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38. Sicherheit und Wirksamkeit interferonfreier antiviraler Therapien in der Behandlung fortgeschrittener HCV-assoziierter Leberzirrhose: Ergebnisse aus dem Deutschen Hepatitis C-Register (DHC-R)

Author

Deterding, K, primary, Buggisch, P, additional, Klinker, H, additional, Simon, KG, additional, Böker, K, additional, Schott, E, additional, Zimmermann, T, additional, Cornberg, M, additional, Günther, R, additional, Pfeiffer-Vornkahl, H, additional, Sarrazin, C, additional, Manns, MP, additional, Hüppe, D, additional, Wedemeyer, H, additional, and Berg, T, additional

Published
2016
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39. Six weeks of sofosbuvir/ledipasvir (SOF/LDV) are sufficient to treat acute hepatitis C virus genotype 1 monoinfection: The HepNet Acute HCV IV Study

Author

Deterding, K, primary, Spinner, C, additional, Schott, E, additional, Welzel, T, additional, Gerken, G, additional, Klinker, H, additional, Spengler, U, additional, Wiegand, J, additional, Schulze zur Wiesch, J, additional, Pathil, A, additional, Cornberg, M, additional, Umgelter, A, additional, Zöllner, C, additional, Zeuzem, S, additional, der Leyen, H von, additional, Witzendorff, D von, additional, Manns, MP, additional, and Wedemeyer, H, additional

Published
2016
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45. Safety and Efficacy of IFN- Free Antiviral Therapies in Advanced HCV- Associated Liver Cirrhosis: Results from the German Hepatitis C-Registry (DHC-R)

Author

Deterding, K., primary, Buggisch, P., additional, Klinker, H., additional, Simon, K.-G., additional, Böker, K.H.W., additional, Schott, E., additional, Zimmermann, T., additional, Cornberg, M., additional, Günther, R., additional, Pfeiffer-Vornkahl, H., additional, Sarrazin, C., additional, Manns, M.P., additional, Hüppe, D., additional, Wedemeyer, H., additional, and Berg, T., additional

Published
2016
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46. Safety of Direct-Acting Antivirals-Based Therapy for the Treatment of Patients with Chronic Hepatitis C Virus Infection and Cirrhosis: Results from an International Multicenter Cohort Study

Author

Maan, R., primary, van Tilborg, M., additional, Deterding, K., additional, Ramji, A., additional, van der Meer, A.J., additional, Wong, F., additional, Fung, S., additional, Sherman, M., additional, Manns, M.P., additional, Cornberg, M., additional, Wedemeyer, H., additional, Janssen, H.L., additional, de Knegt, R.J., additional, and Feld, J.J., additional

Published
2016
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49. Six Weeks of Sofosbuvir/Ledipasvir (SOF/LDV) are Sufficient to Treat Acute Hepatitis C Virus Genotype 1 Monoinfection: The Hepnet Acute HCV IV Study

Author

Deterding, K., primary, Spinner, C., additional, Schott, E., additional, Welzel, T., additional, Gerken, G., additional, Klinker, H., additional, Spengler, U., additional, Wiegand, J., additional, Schulze zur Wiesch, J., additional, Pathil, A., additional, Cornberg, M., additional, Umgelter, A., additional, Zöllner, C., additional, Zeuzem, S., additional, von der Leyen, H., additional, von Witzendorff, D., additional, Manns, M.P., additional, and Wedemeyer, H., additional

Published
2016
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