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What are the short- and medium-term effects of an import-competition shock on firm dynamics and aggregate productivity? We address this question by combining detailed data on investment dynamics of Peruvian manufacturing firms, data on trade flows from China, and a quantitative general-equilibrium model with heterogeneous firms subject to idiosyncratic shocks. In the data, we find evidence of substantial frictions that slow capital reallocation, by rendering disinvestment and firm exit costly. In our model, these frictions shape the transitional dynamics after a trade shock. On impact, a drop in output prices due to import competition induces a spike in inaction, and exit of some productive firms, consistent with our empirical evidence. These effects expand the aggregate productivity wedge relative to a frictionless benchmark. Overall, productivity gains materialize slowly over time, whereas welfare gains emerge early in the transition.

Background Detailed data on intensive care unit (ICU) occupancy in Japan are lacking. Using a nationwide inpatient database in Japan, we aimed to assess ICU bed occupancy to guide critical care utilization planning. Methods We identified all ICU patients admitted from January 1, 2015 to December 31, 2018 to ICU-equipped hospitals participating in the Japanese Diagnosis Procedure Combination inpatient database. We assessed the trends in daily occupancy by counting the total number of occupied ICU beds on a given day divided by the total number of licensed ICU beds in the participating hospitals. We also assessed ICU occupancy for patients with mechanical ventilation, patients with extracorporeal membrane oxygenation, and patients without life-supportive therapies. Results Over the 4 study years, 1,379,618 ICU patients were admitted to 495 hospitals equipped with 5,341 ICU beds, accounting for 75% of all ICU beds in Japan. Mean ICU occupancy on any given day was 60%, with a range of 45.0% to 72.5%. Mean ICU occupancy did not change over the 4 years. Mean ICU occupancy was about 9% higher on weekdays than on weekends and about 5% higher in the coldest season than in the warmest season. For patients with mechanical ventilation, patients with extracorporeal membrane oxygenation, and patients without life-supportive therapies, mean ICU occupancy was 24%, 0.5%, and 30%, respectively. Conclusion Only one-fourth of ICU beds were occupied by mechanically ventilated patients, suggesting that the critical care system in Japan has substantial surge capacity under normal temporal variation to care for critically ill patients.

Many expert reviews of products such as cars, books, movies and restaurants are non -blind. Whether such reviews can be taken at face value is questionable, but hard evidence on the presence of reviewer bias is rare. This holds particularly true for conflicts of interest that are thought to be common in non-blind product reviews but are not readily observ-able: ad hoc relationships between reviewers and producers. We present a textbook case of a long-running expert product review in the food service industry for which we know the reviewer's conflict of interest: being affiliated to one particular producer. As is typical, only insiders were aware of the possible source of bias in the review. The review resembles other non-blind tests of product quality. We find evidence of a sizable bias in the review-ers' ratings. Our findings suggest that reviewers' ad hoc relationships with producers, often dismissed as 'coming with the job', can be very harmful. (c) 2022 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ )

"Network adequacy regulations" expand patients' access to hospitals by mandating a lower bound on the number of hospitals that health insurers must include in their networks. Such regulations, however, compromise insurers' bargaining position with hospitals, which may increase hospital reimbursement rates, and may consequently be passed through to consumers in the form of higher premiums. In this paper, I quantify this effect by developing a model that endogenously captures: (i) how insurers form hospital-networks, (ii) how they bargain with hospitals over rates by threatening to drop them out of network or to replace them with an out of network hospital, and (iii) how they set premiums in an imperfectly competitive market. I estimate this model using detailed data from a Massachusetts health insurance market, and I simulate the effects of a range of regulations. I find that "tighter" regulations, which force insurers to include more than 85% of the hospital-systems in the market, raise the average reimbursement rates paid by some insurers by at least 28%. More moderate regulations, however, can expand the hospital networks without leading to large hikes in reimbursement-rates.

The current study provides detailed data that speaks to the nature of resistance to Flipped Learning pedagogy within a higher education context. A qualitative analysis of this data using the conceptual lens of Judith Butler’s theory of performativity drew attention to a pervasive belief that teaching is and should be an embodied performative act. Findings revealed that perceived or actual increased workload, equity and, relevance to observed practice were key to understanding the nature of resistance embedded within an implicit understanding of what it means to do teaching. Findings have theoretical and practical significance for higher education pedagogical innovation.

Background: The latest global melanoma disease burden and changes are rarely reported, which is important for developing potential strategies to reduce the melanoma-related burden. The aim of this study was to examine the variations and trends in the burden of melanoma between 1990 and 2019. Methods: We extracted detailed data about melanoma from the 2019 Global Burden of Disease study in 204 countries and territories. Detailed data includes the number of melanoma incident cases, deaths, DALYs, and age-standardized rates. We calculated the estimated annual percentage change (EAPC) to quantify the temporal trends of the age-standardized rates of melanoma, and analyzed the influential factors of EAPCs by Spearman correlation. Findings: From 1990 to 2019, the incidence of melanoma cases increased by 170% to 289 950, death increased by 90% to 62 840, and DALYs increased by 67% to 1 707 800 globally. The age-standardized incidence rate (ASIR) of melanoma increased globally by an average of 1 · 13 (95% CI, 0·93-1·32) while the ASRs of mortality and DALYs both declined with the EAPC of -0·27(95% CI, -0·36 to -0·19) and -0·49(95% CI, -0·57 to -0·41), respectively. In 2019, the highest burden of melanoma was observed in high SDI regions , especially Australasia (ASIR=43·36/100 000) and High-income North America regions (ASIR=16·62/100 000). The increasing trend in ASIR was observed in most countries (159/204) , with the highest increase in South Korea, followed by Belarus and Guatemala. However, decreasing or stable trends in ASRs of mortality and DALYs were detected in almost half of countries (102/204; 117/204) except for the low-middle SDI regions such as Guatemala. Interpretation: The variations and trends of melanoma burde n differed greatly across the world. Albeit the overall ASRs of mortality and DALYs declined, the ASIR of melanoma incrementally rose in most countries, which implies more targeted strategies should be taken for areas and groups with relatively higher burden. Funding Information: This work was supported by the National Key Research and Development program of China (grant number: 2017YFC0907003), the National Natural Science Foundation of China (grant numbers: 81973116 and 81573229), and the Shandong Provincial Natural Science Foundation (grant number: ZR2020QH302). Declaration of Interests: The authors declare no potential conflicts of interest. Ethics Approval Statement: Ethics approval was exempted by the Ethics Committee of Qilu Hospital of Shandong University, because the GBD 2019 study is a publicly available database and all data were anonymous. My study does not involve human subjects.

BackgroundProstate Cancer is the second lethal malignancy in men worldwide. In the past, numerous research groups investigated the omics profiles of patients and scrutinized biomarkers for the diagnosis and prognosis of prostate cancer. However, information related to the biomarkers is widely scattered across numerous resources in complex textual format, which poses hindrance to understand the tumorigenesis of this malignancy and scrutinization of robust signature. To the best of authors’ knowledge, there is no resource that can consolidate the information contained in all the published literature.ResultsHere, we present ProCanBio, a manually curated database that maintains detailed data on 2053 entries of potential prostate cancer biomarkers obtained from 412 publications in user friendly tabular format. Among them, 766 protein-based, 488 RNA-based, 157 genomic mutations, 261 miRNA-based, and 122 are metabolites-based biomarkers. To explore the information in the resource, a web-based interactive platform was developed with searching, and browsing facilities. ProCanBio is freely available and is compatible with most web browsers and devices. Eventually, we anticipated this resource will be highly useful for the research community involved in the area of prostate malignancy.AvailabilityProCanBio is available at: https://webs.iiitd.edu.in/raghava/procanbio/

Introduction The accuracy of pharmacokinetic (PK)-guided dosing depends on the clinical and laboratory data used to construct a population PK model, as well as the patient's individual PK profile. This review provides a detailed overview of data used for published population PK models for factor VIII (FVIII) and factor IX (FIX) concentrates, to support physicians in their choices which model best suits each patient. Furthermore, to enhance detailed data collection and documentation, we do suggestions for best practice. Methods A literature search was performed; publications describing prophylactic population PK models for FVIII and FIX concentrates based on original patient data and constructed using non-linear mixed-effect modeling were included. The following data were collected: detailed demographics, type of product, assessed and included covariates, laboratory specifications and validation of models. Included models were scored according to our recommendations for best practice, specifically scoring the quality of data documentation as reported. Results Respectively, twenty models for FVIII and seven for FIX concentrates were retrieved. Although most models (22/27) included pediatric patients, only four reported detailed demographics. The wide range of body weights suggested that overweight and obese adults were represented. Twenty-six models reported the assay applied to measure factor levels, whereas only 16 models named reagents used. Eight models were internally validated using a data subset. Conclusion This overview presents detailed information on clinical and laboratory data used for published population PK models. We provide recommendations on data collection and documentation to increase the reliability of PK-guided prophylactic dosing of factor concentrates in hemophilia A and B.

I develop an empirical framework to disentangle dierent sources of consumer inertia in the US wireless industry. The use of a detailed data set allows me to identify preference heterogeneity from consumer type-specific market shares and switching costs from churn rates. Identification of a localized network eect comes from comparing the dynamics of distinct local markets. The central condition for identification is that neither the characteristics defining consumer heterogeneity nor the characteristics defining reference groups are a (weak) subset of the other. Being able to separate switching costs and network eects is important as both can lead to

This study investigates the pronunciation difficulty of selected English consonant clusters (CCs) encountered by Saudi EFL learners. The sample consisted of 134 female Saudi EFL students in their freshman year in the English Department at Najran University. Two instruments were used: a pronunciation test that assessed participants’ CC pronunciations in the onset and coda positions and a questionnaire that explored participants’ attitudes towards their CC pronunciations. This study provides detailed data on the participants’ pronunciation difficulties using Optimality Theory (OT). The results showed that the participants encountered CC pronunciation difficulties in both the onset and coda positions. However, most errors occurred in the coda position, especially for the four-consonant pattern (-CCCC). Participants used different strategies to simplify their CC pronunciations: epenthesis, deletion, substitution, or some combination thereof. Questionnaire data indicated that the participants attributed their pronunciation difficulties to inadequate knowledge of the pronunciation rules, insufficient language instruction, and native-language influence. The participants proffered some remedies to their difficulties, which included doing more pronunciation drills and offering a new course focused primarily on correct pronunciation. OT analysis revealed that onset clusters were mainly influenced by L1 ranking constraints whereas coda clusters were more influenced by universal Markedness constraints. OT indicated that the tendency to satisfy Markedness constraints over the Faithfulness constraints led the participants to use the above-mentioned simplification strategies.

Groundwater is one of the primary and most safe sources of freshwater supplies to sustain human life. Emerging contaminants (ECs) including pharmaceutical contaminants (PhACs), personal care products (PCPs), endocrine-disrupting compounds (EDCs), synthetic chemicals, and artificial sweeteners (ASWs) are detected in groundwater supplies in trace amounts, raising concerns about the possible adverse effects on humans and the ecosystem; thus, surveillance of contaminants is important to minimize risks. Therefore, this paper reviews more than 50 studies (2000–2020) that provide accurate and analytical information on PhACs and their composition in groundwater. In specific, detailed data on the occurrence and impact of ECs in various water body matrices are systematically analyzed and classified with respect to distinct groups (PhACs, PCPs, EDCs, ASWs, etc.). The main objective of this study is to (1) evaluate groundwater contamination via depicting occurrence and classification of PhACs as ECs, (2) analyze the health and ecological risk due to emerging PhACs, and (3) showcase challenges faced by industries and future prospects for further research on PhACs. The correlation between the occurrence of PhACs and their related health and ecological risks can be easily understood by this paper, which opens a new gateway to discover analytical strategies for future surveillance research works and to fill in the research gaps found in the existing state of knowledge on PhACs.

Recently, several studies have presented quantitative data of lithic assemblages from Islands Southeast Asia (ISEA), based on technological and morphological analyses. While this has led to a better overall understanding of the nature of these assemblages, there is still lack of clarity about the relationship between manufacturing technology and usage. Accordingly, this study collected detailed data of lithic assemblages from Callao Cave in northern Luzon, Philippines. Multifaceted analyses including technological and morphological analysis and use-wear analysis were conducted to clarify the actual nature of lithic technology and tool use in relation to human behavior. Results of the technological and morphological analysis show that several core tools share same types of secondary reduction (retouch) with flake tools, while there are several retouched tools (flake tools and core tools) with several types of secondary reduction (retouch). In addition, there are no major differences between the sizes of the core tools and flake tools. Result of the use-wear analysis indicates that several retouched areas on both the core tools and flake tools were actually used. These stone-tool manufacturing and usage characteristics suggest that the hunter-gatherers who left the assemblages did not clearly distinguish between cores and flakes (or between core tools and flake tools), and did not treat lithic tools as single-function items. That is, it appears that secondary reduction was completed depending on the shapes, thicknesses, and angles of the edges of these lithic artifacts. The users/manufacturers thus placed emphasis on functional edges. It also seems that the core tools were used as both tools and objects for flake production. The characteristics of the assemblages in manufacturing and their usage suggest that lithic artifacts and lithic raw materials were used in Callao Cave efficiently and economically. Furthermore, in terms of their primary and secondary reduction processes, the assemblages from Callao Cave are considerably different from Upper Paleolithic assemblages found in the northern regions of Eurasia. This indicates that the characteristics of stone tool manufacturing and usage in Callao Cave reflect another strategy of early modern humans for using lithic raw material. However, these characteristics of the assemblages may most closely reflect the characteristics of the occupations and activities in the site. Accordingly, similar analyses, including technological and morphological analysis and use-wear analysis, need to be conducted on other lithic assemblages which are composed of many lithic artifacts in ISEA.

Triggered by a territorial dispute as well as historical animosity, a nationwide civilian boycott of Japanese products took place in China in the summer of 2012. Using detailed data on vehicle sales in four major Chinese cities (Beijing, Tianjin, Shanghai, and Nanjing), this study investigates the impact of boycotts on sales and advertising effectiveness of products from different countries of origin. The boycott dramatically reduced the market share of Japanese brands and benefitted Chinese and non-Japanese foreign brands. Consumer switching to other brands accounted for the majority of the loss in sales. Advertising became less effective for Japanese brands during the boycott but more effective for non-Japanese brands, especially at the parent-brand level (e.g., Toyota) than sub-brand level (e.g., Camry). The sales impacts were strongest in Nanjing, the city that had the most atrocious war experience with Japan during the Battle of Nanjing in 1937, and weakest in Beijing, where local government agencies explicitly discouraged public demonstrations. Finally, although the decline in sales of Japanese brands did not vary by quality or production location, competing non-Japanese brands that were had better quality or were manufactured locally benefitted more. This paper was accepted by Juanjuan Zhang, marketing.

Minimally invasive surgery (MIS) is appropriate for the treatment of some neuroblastomas (NBs); however, the indications and technical issues are unclear. This study aimed to clarify the current status of MIS for mediastinal NB in Japan. Preliminary questionnaires requesting the numbers of neuroblastoma cases in which MIS was performed from 2004 to 2016 were sent to 159 Japanese institutes of pediatric surgery. Secondary questionnaires were sent to institutions with MIS cases to collect detailed data. One hundred thirty-four (84.2%) institutions returned the preliminary questionnaire and 83 institutions (52.2%) reported a total of 1496 operative cases. MIS was performed for 175 (11.6%) cases. Among the 175 cases, completed forms of 140 patients were returned and 40 (male, n = 28; female, n = 12) cases had mediastinal NB. Fourteen patients received thoracoscopic biopsy, none were converted to thoracotomy. Twenty-eight patients received MIS for radical resection, none were converted to thoracotomy. Perioperative complications (Horner’s syndrome) were recognized after radical resection in one (2.5%) case. MIS was performed in a limited number of mediastinal NB cases. A thoracoscopic approach would be feasible for mediastinal NB.

Unggas adalah jenis hewan ternak kelompok burung yang dimanfaatkan untuk daging dan telur atau bulunya. Selama ini Abdi Poultry masih melakukan pencatatan hasil pemeliharaan dan hasil produksi unggas dengan cara manual, mulai dari pencatatan jumlah bibit unggas, pencatatan unggas yang sakit atau mati, pencatatan stok pakan, vitamin dan obat, pencatatan jumlah hasil produksi unggas. Pencatatan manual tersebut menyebabkan rentan terjadinya dokumen menumpuk dan hilang, kesulitan dalam pencarian data, data kurang akurat dan mendetail. Berdasarkan permasalahan yang terjadi muncul sebuah ide untuk membuat Aplikasi Monitoring Peternakan Unggas Berbasis Web yang dapat mendukung kegiatan peternak dalam pencatatan data dan monitoring yang bertujuan untuk mempermudah proses pemeliharaan unggas mulai dari bibit datang hingga panen. Aplikasi ini dibuat menggunakan metode pengembangan sistem Waterfall karena metode pengembangan perangkat lunak ini memungkinkan pembuatan sistem dilakukan secara terstuktur dan sistematis (berurutan) sesuai dengan siklus pengembangan yang dapat memberikan solusi terhadapat permasalahan yang ada.

We use detailed data from a large retail panel to study the effect of participation in the Supplemental Nutrition Assistance Program (SNAP) on the composition and nutrient content of foods purchased for at-home consumption. We find that the effect of SNAP participation is small relative to the cross-sectional variation in most of the outcomes we consider. Estimates from a model relating the composition of a household’s food purchases to the household’s current level of food spending imply that closing the gap in food spending between high- and low-SES households would not close the gap in summary measures of food healthfulness. (JEL D12, H75, I12, I18, L66)

PurposeSexual assault investigations present uniquely challenging circumstances to detectives, and a small proportion result in arrest. Improving sexual assault investigations requires expanding the evidence base to improve our understanding of how these investigations unfold and the factors associated with positive case outcomes, including the likelihood that an offender is arrested.Design/methodology/approachThe authors abstracted data on 491 adult sexual assaults investigated by five large and midsized law enforcement agencies to describe the characteristics of sexual assault investigations and to explain the relationships between these characteristics and the likelihood that a suspect is arrested.FindingsOverall, detectives move swiftly to investigate sexual assaults but tend to miss investigative opportunities that increase the likelihood of an arrest, like locating and processing the crime scene or pursuing interviews with key witnesses and leads. Sexual assaults typically lack physical evidence that can be used to identify and lead to an arrest of a suspected offender; when this evidence is present, the case is more likely to result in an arrest. Delayed reporting of the crime to law enforcement decreases the likelihood of a suspect being arrested, but the mechanisms are unclear.Originality/valueFew studies have used a detailed data abstraction process for a large sample of cases from multiple law enforcement agencies to understand sexual assault investigations and their case outcomes. The results can improve practitioners' and researchers' understanding of sexual assault investigations, including those factors that increase the likelihood of a suspect's arrest.

Background Congenital limb deficiency is a rare anomaly that impairs limb function. Transverse deficiency accounts for approximately half of congenital limb deficiency cases. In Japan, there have been no detailed data of clinical features, especially treatment approaches, of this disorder. The present study aimed to investigate the status of treatment approaches of congenital transverse limb deficiency in Japan. Methods From the national epidemiological survey of congenital limb deficiency undertaken in Japan in 2016, all the data of 200 patients with congenital transverse limb deficiencies were extracted. These data were analysed to reveal the treatment approaches of congenital transverse limb deficiency and its basic clinical features. Results Surgical treatments and prosthetic or orthotic intervention had been implemented or planned for about one-quarter of patients, respectively. In the upper limb deficiencies, prosthetic or orthotic intervention was likely chosen in cases of deficiency at the metacarpal or proximal to metacarpal level. Surgical treatment was chosen only in cases of deficiency at the carpal or distal to carpal level. Although the number of patients with transverse lower limb deficiencies was small, prosthetic or orthotic intervention was likely chosen in proximal deficiencies, and surgical treatment was likely chosen in distal deficiencies. Conclusions Herein, we revealed the status of treatment approaches for congenital transverse limb deficiency in Japan. Approximately half of the patients had no history of—and no plans for—surgical, prosthetic, or orthotic interventions. Further treatment advances may enable patients with congenital limb deficiencies to increase their participation in daily activities. Study Design Cross-sectional survey.

The field of academic finance has grown and evolved in the 47 years since the Journal of Financial Economics (JFE) began publishing papers. This paper examines detailed data on the 3,003 papers written by 3,358 different authors published in the JFE over the period 1974–2020. Advances in computing power and electronic communication have driven trends toward more empirical work, more coauthorship, and more complex papers. The set of authors, referees, and editors has also evolved as the field spans a much larger geographic footprint and as women have come to play a larger role in all aspects of academic finance. Growth in the demand for finance faculty has driven up faculty compensation and the demand for scarce journal space. Also see the internet appendix for additional data here: https://ssrn.com/abstract=3722314.

The purpose of this study is to investigate the metacognitive strategies that middle school students used in the process of solving problems individually. The study group consisted of 37 middle school students in the eighth grade. The students were asked one non-routine word problem, and their written answers were collected. After solving the problem, the students filled out a self-monitoring questionnaire that requested them to reflect retrospectively on the metacognitive strategies they employed for the problem. In order to obtain detailed data, semi-structured interviews were conducted with six students, three of whom gave correct responses and the other three gave wrong answers to the problem. The data was analyzed through the model of metacognitive activity during problem-solving. The results showed that metacognitive skills have a significant effect on students’ problem-solving success. The study found that students with high metacognitive skills tend to solve the problem correctly by using appropriate strategies, mathematical notations and logical reasons. The results also revealed that students with poor metacognitive skills have difficulties in understanding the problem, selecting appropriate strategies, and finding correct answer. Although the students thought the opposite, it was concluded that their habits of checking, detecting, and correcting mistakes in their solutions were poor.

The article indicates the advantage of carrying out rail transportation, but it is determined that today there is a certain lag in this area from the needs of the national economy, which is provoked by limited territory, slow modernization of railways, and high deterioration of the locomotive fleet. As a result, this leads to an increase in crime at transport facilities, and one of the effective elements in the formation of the evidence base in such criminal cases is the use of technical and forensic research of documents. So, the work describes the possibilities of a technical and forensic study of documents, as well as those results of the research that are necessary to build a solid evidence base in a criminal case. The stages of the implementation of technical and forensic research documents. The specifics of production, the difficulties in forming conclusions on the study. In addition, it is determined that today there is a need for replenishment of forensic centers with accurate and detailed data regarding the description of various seals and forms of higher education used in the railway sector, which will allow for better research and help in drawing conclusions. It was found that such data will help in establishing the facts of the manufacture of fake documents, will narrow the circle of the search for the criminal.

Under the stated goal of improving air quality, many cities in China restricted the import of used vehicles from other cities based on tail pipe emission standards. Using detailed data on new and used vehicle registration, we examine the impact of the policy by leveraging the staggered removal of the restriction during 2016-2018. We find that restriction removal led to a sharp increase in cross-city flow of used vehicles but had no significant impact on local air quality. Unilateral removal of the restriction could reduce new vehicle sales in home cities, but universal removal would boost new vehicle sales nationwide.

Objectives To report available information in the literature regarding frequency, indications, types of antibiotic usage, duration, and their efficacy in Covid-19 infected patients. Methods The search was conducted on April 30 and May 7, 2020, using Ovid database and Google search. Patients’ characteristics, clinical outcomes, as well as selected characteristics regarding antibiotic use (indication, class used, rates and types of bacterial secondary and co-infection, and duration of treatment) were analyzed. Results Nineteen clinical studies reporting data from 2834 patients were included. Mean rate of antibiotic use was 74.0 % of cases. Half the studies reported occurrence of a bacterial co-infection or complication (10 studies). Amongst the latter, at least 17.6 % of patients who received antibiotics had secondary infections. Pooled data of 4 studies show that half of patients receiving antibiotics were not severe nor critical. Detailed data on antibiotic use lack in most articles. Conclusions The present review found a major use of antibiotics amongst Covid-19 hospitalized patients, mainly in an empirical setting. There is no proven efficacy of this practice. Further research to determine relevant indications for antibiotic use in Covid-19 patients is critical in view of the significant mortality associated with secondary infections in these patients, and the rising antimicrobial resistance.

Li Zhang,1,2,* Minjie Liu,2,3,* Jianying Li,2,4,* Xiaoli Li,3,* Li Cheng,3 Yahong Ji,3 Na Li,3 Junning Wang2,3 1Department of Intensive Care Unit, Honghui Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi, 710054, People’s Republic of China; 2Xi’an Public Health Center, Xi’an, Shaanxi, 710200, People’s Republic of China; 3Department of Respiratory, Honghui Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi, 710054, People’s Republic of China; 4The Department of Respiratory Medicine, Xi’an Central Hospital, The Affiliated Hospital of Xi’an Jiaotong University College of Medicine, Xi’an, Shaanxi, 710003, People’s Republic of China*These authors contributed equally to this workCorrespondence: Junning WangDepartment of Respiratory, Honghui Hospital, Xi’an Jiaotong University, No. 555, Youyi East Road, Nanshaomen, Xi’an, Shaanxi, 710054, People’s Republic of ChinaTel +86 02962818354Fax +86 02962818354Email wangjunningde@163.comBackground: Effective management of foreign-imported COVID-19 cases is a new and great challenge for China. Our study focused on the foreign-imported COVID-19 cases to provide detailed data for insights into the prevention, early diagnosis, treatment and control of imported COVID-19.Methods: For this observational and retrospective study, we investigated the clinical characteristics of imported COVID-19 cases that were confirmed by real-time RT-PCR in the Xi’an Public Health Center from 29 March 2020 to 31 August 2020.Results: Of the 79 patients with COVID-19, 19 (24.1%) had exposure to confirmed COVID-19 patients, 15 (19.0%) had exposure to suspicious COVID-19 patients, and 45 (56.9%) had an unclear history of exposure to confirmed patients. The mean age of the patients was 38 years, and 70 (88.7%) patients were male. Except for 2 severe cases, the remaining 58 (73.4%) cases displayed mild or moderate symptoms, and 19 (24.2%) infected patients were asymptomatic. Twenty-one (26.6%) patients were not diagnosed until a third or later nucleic acid test. Ten (12.7%) patients had chronic diseases. The most common manifestations of the patients were cough [18 (22.8%) cases], fever [9 (11.4%) cases] and sore throat [9 (11.4%) cases]. Forty-one (51.9%) cases showed abnormal chest CT images, To date, all patients have been discharged, and no patient has died.Conclusion: The imported COVID-19 cases in Xi’an were mainly young and middle-aged adults with mild or moderate symptoms who had a low rate of comorbidity, showed favourable laboratory and chest CT images, and had a better prognosis. Notably, for suspected COVID-19 cases, at least three consecutive nucleic acid tests should be carried out to avoid missed detection of infected patients. Except for severe cases, high-level medical resources are not necessary in most cases.Keywords: COVID-19, SARS-CoV-2, clinical characteristics, foreign-imported cases, pneumonia

Ride-hailing (RH) services have been growing rapidly and gaining popularity worldwide. However, many transit agencies are experiencing ridership stagnation or even decline. Understanding the correlation between RH trips and transit ridership has become an urgently important matter for transit agencies. This study aimed to explore the relationship between RH and public transit ridership and provide a starting point for future studies. This study benefitted from having access to detailed data on trip-level RH trips, transit supply and transit ridership in Toronto for three years (2016–2018). With this dataset, the study utilized random-effects panel data models and log–log regression models to estimate the correlation of RH pickup/drop-off counts with subway station and surface transit route (buses and streetcars) ridership within transit catchment areas, broken down into five different periods of a non-summer weekday. The results show that RH services generally have a positive association with subway station ridership while negatively correlating with surface transit route ridership. The positive relationship between RH and subway station ridership is the strongest during the mid-day and early evening. In contrast, the negative relationship between surface transit routes and RH ridership is the highest during peak commuting hours. Additionally, RH trip volume is more positively related to ridership at terminal/transfer subway stations in Toronto’s city centre while more negatively associated with routes with relatively poor services (e.g., low on-time performance, low vehicle running speed and low frequency) in the city centre where traffic congestion can be severe. According to the above findings, the degree of the relationship between RH and public transit demand tends to be mixed, varying by transit mode, time of day and transit level-of-service. The gained knowledge about RH and transit can provide insights for transit agencies to improve transit services, which are discussed in this paper.

The article is focused on a detailed micro-study describing changes in the behaviour of the authors in three months before and during the COVID-19 pandemic. The study is based on data from Google Location Service. Despite the fact it evaluates only three people and the study cannot be sufficiently representative, it is a unique example of possible data processing at such a level of accuracy. The most significant changes in the behaviour of authors before and during the COVID-19 quarantine are described and interpreted in detail. Another purpose of the article is to point out the possibilities of analytical processing of Google Location while being aware of personal data protection issues. The authors recognize that by visualizing the real motion data, one partially discloses their privacy, but one considers it very valuable to show how detailed data Google collects about the population and how such data can be used effectively.

Serotonin is a neuromodulator that is implicated in awake-sleep cycle, motor behaviors, reward, motivation, and mood. Recent molecular tools for cell-type-specific activity recording and manipulation with fine temporal and spatial resolutions are providing unprecedentedly detailed data about serotonergic neuromodulation. These newly gained information show substantial differences in the signaling and effect of serotonergic neuromodulation depending on the projection targets. To find the common denominator for this diversity, we conjecture that the evolution of serotonergic neuromodulation originates from signaling the time and resource available for action, learning, and development.

Using detailed data on the beneficiaries of the Korean National Health Insurance Service (c.2006–2015), this paper estimates the health effects of air pollution in South Korea while controlling for avoidance behaviors. In particular, we investigate changes in respiratory hospitalization rates due to increases in PM $$_{10}$$ and O $$_{3}$$ concentrations. To address the endogeneity of air pollution, this paper applies the historical average concentration of air pollution, which includes rich information about the meteorological and geographical factors that affect regional air pollution levels, as an instrumental variable and compares the results with other count data models. We find that a 10 $$\upmu$$ g/m $$^{3}$$ increase in PM $$_{10}$$ and a 10 ppb increase in O $$_{3}$$ lead to an increase in daily respiratory hospital visits of up to 10.39% [95% confidence interval (CI) 4.04–16.80] and 10.93% (95% CI 9.23–12.63), resulting in additional health care costs of US$67 million and US$70 million, respectively. This paper also shows that the effects of PM $$_{10}$$ and O $$_{3}$$ are elevated in highly populated cities, children, and patients without chronic respiratory diseases.

Background: Football is known as the world's No. 1 sport and has always been loved by the majority of young people. The development of football on campus also has a long history and an extensive positive influence. It is recognized as a sport with good exercise value. With the increasingly close connection between football and social life, the development of university football is inevitably affected by many social factors. Through the analysis of the macro-development environment and development status of university football, it discusses the social factors affecting the development of university football from various aspects such as social systems, traditional ideas, and values. Method: Employing literature review, logical analysis, discussion with players, and experts interview methods, the athletes and coaches of university football teams were visited and investigated. Based on the guidance of players and coaches this paper summarizes the present situation of the football players of Pakistan with detailed data. Conclusion: The development of University Football faces the double lag of hardware and software facilities, and the competent supervision department of the state cooperate insufficient execution, weak University Football culture atmosphere, etc. are all bad factors that restrict and affect the development of University Football in our country.

What are the determinants of in-house employment versus outsourcing in the service sector? I use detailed data on U.S. lobbying services to answer this question. I argue with a series of correlational exercises that firms tend to outsource lobbying tasks that demand a large amount of general skills, whereas they are more likely to assign firm-specific tasks to in-house lobbyists. I provide causal evidence that the need to do tasks that vary in their general skill component leads to a change in outsourcing. Using difference-in-difference estimations, I show that the 2010 British Petroleum oil spill increased the general skills needed by oil and gas firms and that, consequently, their use of lobbyists for hire increased. This paper was accepted by Joshua Gans, business strategy.

The geological and geophysical data obtained during the 50th cruise of R/V Akademik Nikolaj Strakhov on the Charlie Gibbs megatransform system structure in the North Atlantic are presented. The structure of the Charlie Gibbs Fracture Zone was examined in detail, considering previously published data. It has been shown that the northern and southern segments of the Mid-Atlantic Ridge, separated by the Charlie Gibbs transform fault, are entirely different in morphology, and hence in terms of formation. The dredged rocks are represented by an entire spectrum from the mantle to upper crustal varieties and allow us to determine the origin of the main structures of the Charlie Gibbs megatransform system considering detailed data on the morphology.

In children, renal cell carcinoma (RCC) is rare. This study is the first report of pediatric patients with RCC registered by the International Society of Pediatric Oncology-Renal Tumor Study Group (SIOP-RTSG). Pediatric patients with histologically confirmed RCC, registered in SIOP 93-01, 2001 and UK-IMPORT databases, were included. Event-free survival (EFS) and overall survival (OS) were analyzed using the Kaplan-Meier method. Between 1993 and 2019, 122 pediatric patients with RCC were registered. Available detailed data (n = 111) revealed 56 localized, 30 regionally advanced, 25 metastatic and no bilateral cases. Histological classification according to World Health Organization 2004, including immunohistochemical and molecular testing for transcription factor E3 (TFE3) and/or EB (TFEB) translocation, was available for 65/122 patients. In this group, the most common histological subtypes were translocation type RCC (MiT-RCC) (36/64, 56.3%), papillary type (19/64, 29.7%) and clear cell type (4/64, 6.3%). One histological subtype was not reported. In the remaining 57 patients, translocation testing could not be performed, or TFE-cytogenetics and/or immunohistochemistry results were missing. In this group, the most common RCC histological subtypes were papillary type (21/47, 44.7%) and clear cell type (11/47, 23.4%). Ten histological subtypes were not reported. Estimated 5-year (5y) EFS and 5y OS of the total group was 70.5% (95% CI = 61.7%-80.6%) and 84.5% (95% CI = 77.5%-92.2%), respectively. Estimated 5y OS for localized, regionally advanced, and metastatic disease was 96.8%, 92.3%, and 45.6%, respectively. In conclusion, the registered pediatric patients with RCC showed a reasonable outcome. Survival was substantially lower for patients with metastatic disease. This descriptive study stresses the importance of full, prospective registration including TFE-testing.

Essential thrombocythemia (ET) occurs predominantly in the elderly, but approximately 20% of patients are α was administered but failed to induce an adequate response. She underwent emergency cesarean delivery at 37 weeks of gestation. Although her platelet count was 1000 × 109/L immediately after delivery, it markedly increased to 3271 × 109/L approximately 2 weeks later. Cytoreductive therapy was resumed; the subsequent course was free from complications. Several review articles have indicated that because platelet counts of patients may again increase to the pregnancy level or rebound after delivery, cytoreductive therapy should be administered if necessary. However, there is insufficient information on when therapeutic interventions are necessary and how they should be performed. It remains unknown whether the platelet count will decrease after some time without treatment if it rebounds. We hope management guidelines will be established by collecting detailed data on the postpartum course as well as during pregnancy.

Introduction: The number of road fatalities have been falling throughout the European Union (EU) over the past 20 years and most Member States have achieved an overall reduction. Research has mainly focused on protecting car occupants, with car occupant fatalities reducing significantly. However, recently there has been a plateauing in fatalities amongst ‘Vulnerable Road Users’ (VRUs), and in 2016 accidents involving VRUs accounted for nearly half of all EU road deaths. Method: The SaferWheels study collected in-depth data on 500 accidents involving Powered Two-Wheelers (PTWs) and bicycles across six European countries. A standard in-depth accident investigation methodology was used by each team. The Driver Reliability and Error Analysis Method (DREAM) was used to systematically classify accident causation factors. Results: The most common causal factors related to errors in observation by the PTW/bicycle rider or the driver of the other vehicle, typically called ‘looked but failed to see’ accidents. Common scenarios involved the other vehicle turning or crossing in front of the PTW/bicycle. A quarter of serious or fatal injuries to PTW riders occurred in accidents where the rider lost control with no other vehicle involvement. Conclusions: Highly detailed data have been collected for 500 accidents involving PTWs or bicycles in the EU. These data can be further analyzed by researchers on a case-study basis to gain detailed insights on such accidents. Preliminary analysis suggests that ‘looked but failed to see’ remains a common cause, and in many cases the actions of the other vehicle were the critical factor, though PTW rider speed or inexperience played a role in some cases. Practical Applications: The collected data can be analyzed to better understand the characteristics and causes of accidents involving PTWs and bicycles in the EU. The results can be used to develop policies aimed at reducing road deaths and injuries to VRUs.

Objectives Understanding the global trend of lung cancer deaths attributable to smoking is crucial for prioritizing global lung cancer prevention, as well as tobacco control. We assessed patterns of smoking-induced lung cancer deaths at global, regional, and national levels from 1990 to 2017. Materials and methods We extracted detailed data on lung cancer deaths attributable to smoking from the Global Burden of Disease 2017 Study. The estimated annual percentage change (EAPC) was used to quantify temporal trends in the age-standardized mortality rate (ASMR) of smoking-induced lung cancer. Results In 2017, estimated 1.19 million lung cancer deaths were attributable to smoking, accounting for 63.17 % of all lung cancer deaths. The corresponding ASMR decreased by 13.36 % from 17.29/100,000 in 1990 to 14.98/100,000 in 2017, with an EAPC of −0.59 (95 % confidence interval: −0.66, −0.53). The ASMR of lung cancer in most geographic regions has significantly decreased since 1990; however, the EAPC of ASMR in 20 countries exceeded 1 during the same period. The reductions in the ASMR were pronounced in areas with high Socio-demographic Index and high disease burden, and kept pace with the decrease of smoking prevalence at least 10 years ago. Conclusion Despite the decline in lung cancer ASMR attributable to smoking over the past 28 years, the corresponding number of lung cancer deaths increased steadily due to population aging and growth. Tobacco prevention needs to be strengthened, especially in countries with high smoking prevalence and countries where the ASMR of smoking-induced lung cancer is increasing.

Increased migration, the omnipresent desire to travel, climate change and a globally more mobile population enhance the risk of spreading infectious, tropical pathogens across international borders. In addition to diarrhea and fever, skin diseases present one of the most common reasons for a medical consultation upon return among travelers. These diseases are often caused by parasites. Detailed data on infectious travel diseases is scarce. However, demographic, endemic and travel-related information represent the basic requirements for physicians to choose appropriate diagnostics and adequate treatment for affected patients. This article gives an overview of common parasitic travel dermatoses, their specific diagnostic workup, treatment and preventive measures.

Accurate modeling of bicycles in microsimulation tools is challenging due to the limited availability of detailed data, complexity of cyclist decision-making, and heterogeneity in cycling behavior....

Purpose of review The current review aims to describe in detail the most common practices utilized to monitor graft function in intestinal transplant (ITx) recipients. In addition, to discussing the role of endoscopy and stool studies it will examine the use of other potential biomarkers which have been utilized. Data will be discussed from contemporary publications in the field, the Intestinal Transplant Registry as well as detailed data from a large, ITx single-center. Recent findings Significant improvements have been made in early outcomes following ITx, yet long-term survival remains challenged by infection and rejection, both of which can present with diarrhea. While endoscopy and stool studies are the gold-standard for graft monitoring, calprotectin, citrulline, measurements of immunoreactivity and donor-specific antibodies have been investigated in the field and are herein reviewed. Summary Despite a number of tests which are currently available for monitoring ITx recipients, a strong need exists for improved noninvasive, timely and accurate biomarkers to help improve ITx graft and patient survival.

The performance of solar cells influences the reliability, lifetime, cost, and safety of photovoltaic power plants. The electrical performance of these cells, as well as, their degradation rates over time, can vary between individual cells within the same photovoltaic module. Current–voltage measurements can provide detailed data on cell performance, however, it cannot be performed on individual cells in encapsulated modules. In this study, we propose a contactless and nondestructive method that is based on Suns-photoluminescence measurements to extract the current-voltage characteristics of individual solar cells under operating conditions in the field. Applications of the method to identify the extent of various degradation mechanisms, such as light-induced and potential-induced degradation, are demonstrated and discussed. The main advantages of the proposed method include its low cost, and its fast and easy applicability.

Epidemic risk has great uncertainty and harmfulness, which poses a potential threat to public health in a certain region. Establishing a special risk assessment system to assess and predict the potential epidemic risk of a region can effectively avoid or reduce the impact of epidemic risk. Therefore, this paper combs the related factors that affect the epidemic risk, and proposes an epidemic risk assessment model based on 12 indicators by combining Markov chain and AHP. The model can assess the epidemic situation in a certain region from four aspects: the probability of risk occurrence, the probability of loss, the possibility of risk disappearance and risk duration, so as to provide detailed data for the risk management and control of epidemic in the region, and help the epidemic prevention work to be carried out in a targeted way. Finally, the case analysis and method comparison are carried out,and the results show that the model proposed in this paper is reasonable and feasible.

TiO2 nanoparticles (NPs) are intensively studied and widely used due to their huge potential in numerous applications involving their interaction with ultraviolet light (e.g., photocatalysis and sunscreens). Typically, these NPs are in water-containing environments and thus tend to be hydrated. As such, there is a growing need to better understand the physicochemical properties of hydrated TiO2 NPs in order to improve their performance in photochemical applications (e.g., photocatalytic water splitting) and to minimise their environmental impact (e.g., potential biotoxicity). To help address the need for reliable and detailed data on how nano-titania interacts with water, we present a systematic experimental and theoretical study of surface hydroxyl (OH) groups on photoactive anatase TiO2 NPs. Employing well-defined experimentally synthesised NPs and detailed realistic NP models, we obtain the measured and computed infrared spectra of the surface hydroxyls, respectively. By comparing the experimental and theoretical spectra we are able to identify the type and location of different OH groups in these NP systems. Specifically, our study allows us to provide unprecedented and detailed information about the coverage-dependent distribution of hydroxyl groups on the surface of experimental titania NPs, the degree of their H-bonding interactions and their associated assigned vibrational modes. Our work promises to lead to new routes for developing new and safe nanotechnologies based on hydrated TiO2 NPs.

Treatment of Candidemia has become increasingly complicated as more and more non-albicans Candida species are being isolated in recent years.We launched an investigation of the species, the MIC value, and the state of administration of antifungal drugs for all the cases with Candida spp. confirmed by blood cultures for the 7-year period from 2012 to 2018 at our hospital. In total, 192 cases were found and 206 strains of Candida species were isolated. Overall, 49.5% of the 206 isolated strains were Candida albicans (102 strains), followed by Candida glabrata (40 strains, 19.4%), and Candida parapsilosis (38 strains, 18.4%). The most frequently used antifungal drug for the initial dose was MCFG (120 cases, 59.2%), while the most frequently switched antifungal agent was L-AMB. Cases with an inappropriate end-of-treatment time represented 58.7% of all the cases.We investigated the Candidemia situation at our hospital for a period of seven years. We believe that it is important for medical institutions to gather detailed data on candidemia at their own hospitals. Likewise, the hospital's Infection Control Team/Antimicrobial Stewardship Team should inform the physicians-in-charge about the appropriate diagnosis and treatment based on the data obtained.

The impacts of poor air quality on human health are becoming more apparent. Businesses and governments are implementing technologies and policies in order to improve air quality. Despite this the PM10 air quality in the mining town of Moranbah, Australia, has worsened since measurements commenced in 2011. The annual average PM10 concentrations during 2012, 2017, 2018 and 2019 have all exceeded the Australian National Environmental Protection Measure's standard, and there has been an increase in the frequency of exceedances of the daily standard. The average annual increase in PM10 was 1.2 ± 0.5 μg m − 3 per year between 2011 and 2019 and has been 2.5 ± 1.2 μg m − 3 per year since 2014. The cause of this has not previously been established. Here, two machine learning algorithms (gradient boosted regression and random forest) have been implemented to model and then meteorologically normalise PM10 mass concentrations measured in Moranbah. The best performing model, using the random forest algorithm, was able to explain 59% of the variance in PM10 using a range of meteorological, environmental and temporal variables as predictors. An increasing trend after normalising for these factors was found of 0.6 ± 0.5 μg m − 3 per year since 2011 and 1.7 ± 0.3 μg m − 3 per year since 2014. These results indicate that more than half of the increase in PM10 is due to a rise in local emissions in the region. The remainder of the rise in PM10 was found to be due to a decrease of soil water content in the surrounding region, which can facilitate higher dust emissions. Whether the presence of open-cut coal mines exacerbated the role of soil water content is unclear. Although fires can have drastic effects on the local air quality, changes in fire patterns are not responsible for the rising trend. PM10 composition measurements or more detailed data relating to local sources is still needed to better isolate these emissions. Nonetheless, this study highlights the need and potential for action by industry and government to improve the air quality and reduce health risks for the nearby population.

Using detailed data for U.S. homeowners, we document a negative, nonlinear relation between the loan-to-value ratio (LTV) of homeowners’ primary residence and their labor income. Consistent with high LTV individuals experiencing constrained mobility, we find stronger effects among subprime, liquidity- constrained individuals and those living in regions with limited alternative local employment opportunities and strict noncompete law enforcement. Though high LTV individuals are less likely to move across MSAs, they are more likely to change jobs without changing their residence. We find no effects among similar neighboring renters employed at the same firm and with a similar job tenure.

Intermittently, Singapore suffers from severe air pollution in periods of intense forest and peatland fires on neighboring South-Asian islands. A recent American Economic Review article modeled the causal relationships between fire intensity in Indonesia and air pollution (PSI) in Singapore, and between PSI and health clinic visits in Singapore. We find serious flaws in the quantitative assessment of these relationships. Attempts are made to repair these using the same classic methodology and data, but also by alternative methods requiring less speculative assumptions. Although actually more detailed data are required, there are some results produced which seem more credible.

The research was backed by researchers ' interest to examine the guiding principles of guidance and counseling in North Sumatera regional Police School. This research aims to find out how the role of guidance and counseling in Mental development activities in North Sumatera regional Police School. Mental view of students who are studying police schools in North Sumatera regional Police School. The method used in this research is qualitative in the narrative approaches, That is, the research procedure that produces the detailed data of the written or oral words of the observed behaviour. The research of guidance and counseling principles in North Sumatera regional Police School: First, the role of caregiver in the motivation of the state Police school students by applying the principles in guidance and counseling, so it is achieved a good and mental healthy learning. This can be seen from the student's success to complete the learning process at the state Police School. Secondly, students ' mental assessment is reviewed from the issue that students have restrictions and obligations. This is included in the final aspect of this diploma in: Academic values, physical value and the most important mental value of personality are mental values of personality.

For the purpose of examining the characteristics of dyslipidemia and fatty liver in patients with Werner syndrome in Japan in recent years, we searched all case reports of Japanese Werner syndrome reported on Medical Online and PubMed since 1996, and collected and examined the data and clinical features described in these reports. In addition, as there are few descriptions of treatment methods in these reports from Medical Online and PubMed, we analyzed 12 cases for which detailed data on treatment methods are available at Chiba University. Geriatr Gerontol Int 2021; 21: 133-138.

The detailed data of the Vp/Vs ratio and porosity logs were used to detect the Oil-Water Contact Zone (OWCZ) of Nahr Umr sandstone and Mishrif limestone reservoir formations in Kumiat (Kt) and Dujaila (Du) oil fields, southeastern Iraq. The results of OWC were confirmed using P-wave, Resistivity, and Water Saturation (Sw) logs of Kt-1 and Du-1 wells. It was found that the values of the oil-water contact zone thickness in Nahr Umr sandstone and Mishrif limestone were approximately one meter and eight meters, respectively. These results suggest that the OWCZ is possibly thicker in the carbonate rock than clastic rock formations. The thickness of OWCZ in the clastic rocks changed from one part to another, depending on several factors including mineral composition, grain size, porosity, pore shape, and fluid type.

Data from a campus climate/violence survey (CCS) include psychometric information for survey items/scales plus findings from a large state university to promote its usefulness for assessment of interpersonal violence/harassment. This CCS can thus be evaluated for its measurement and documented findings, allowing for benchmarking purposes. An innovative measurement strategy is introduced to comprehensively capture incidence of victimization types through streamlined questioning. Tables provide detailed data for 6,995 undergraduate and graduate/professional students over a 1-year period. Adding to published literature on existing CCSs, this article provides the range of information needed for universities to determine the potential usefulness of a CCS.

The purpose of this study was to measure student, academic ability using cumulative grade point average achieved during the study at Universitas Islam Syekh-Yusuf Tangerang. By conducting in-depth interviews, observation, and direct involvement, comprehensive and detailed data was generated. The results showed that student, academic ability was not optimal although the cumulative grade point average was in the range of 3.0-3.27 which could be improved through the role of professional lecturers. A good learning process could help student, academic ability improvement. Keywords: academic ability, the role of professional lecturers, a good learning process, grade point average