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15. Virological response to darunavir in patients infected with HIV is linked to darunavir resistance–associated mutations corrected by the count of mutations with positive impact and is not associated with pharmacological and combined virological/pharmacological parameters

Author

Dailly, Eric, Rodallec, Audrey, Allavena, Clotilde, Deslandes, Guillaume, Garnier, Elisabeth, Billaud, Eric, Ferré, Virginie, Reliquet, Véronique, Bouquié, Régis, Raffi, François, and Jolliet, Pascale

Published
2012
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17. Should we reconsider cefazolin for treating staphylococcal meningitis? A retrospective analysis of cefazolin and cloxacillin cerebrospinal fluid levels in patients treated for staphylococcal meningitis

Author

Le Turnier, P., primary, Gregoire, M., additional, Deslandes, G., additional, Lakhal, K., additional, Deschanvres, C., additional, Lecomte, R., additional, Talarmin, J.-P., additional, Dubée, V., additional, Bellouard, R., additional, Boutoille, D., additional, Leroy, A.-G., additional, Gaborit, B.J., additional, Raffi, Francois, additional, Boutoille, David, additional, Biron, Charlotte, additional, Lefebvre, Maeva, additional, Gaborit, Benjamin Jean, additional, Le Turnier, Paul, additional, Deschanvres, Colin, additional, Lecomte, Raphael, additional, Chauveau, Marie, additional, Asseray, Nathalie, additional, Gregoire, Matthieu, additional, Bellouard, Ronan, additional, Deslandes, Guillaume, additional, Dailly, Eric, additional, Leroy, Anne-Gaëlle, additional, Corvec, Stéphane, additional, Bémer, Pascale, additional, Caillon, Jocelyne, additional, Guillouzouic, Aurélie, additional, Lakhal, Karim, additional, Cinotti, Raphaël, additional, Canet, Emmanuel, additional, Bretonniere, Cédric, additional, Guimard, Thomas, additional, Brochard, Julia, additional, Talarmin, Jean Philippe, additional, and Katchatourian, Lydie, additional

Published
2020
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19. High-Dose Ceftriaxone for Bacterial Meningitis and Optimization of Administration Scheme Based on Nomogram

Author

Grégoire, Matthieu, primary, Dailly, Eric, additional, Le Turnier, Paul, additional, Garot, Denis, additional, Guimard, Thomas, additional, Bernard, Louis, additional, Tattevin, Pierre, additional, Vandamme, Yves-Marie, additional, Hoff, Jérôme, additional, Lemaitre, Florian, additional, Verdier, Marie-Clémence, additional, Deslandes, Guillaume, additional, Bellouard, Ronan, additional, Sébille, Véronique, additional, Chiffoleau, Anne, additional, Boutoille, David, additional, Navas, Dominique, additional, and Asseray, Nathalie, additional

Published
2019
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22. High-Dosage Cefazolin Achieves Sufficient Cerebrospinal Diffusion To Treat an External Ventricular Drainage-Related Staphylococcus aureus Ventriculitis

Author

Grégoire, Matthieu, primary, Gaborit, Benjamin, additional, Deschanvres, Colin, additional, Lecomte, Raphaël, additional, Deslandes, Guillaume, additional, Dailly, Éric, additional, Ambrosi, Xavier, additional, Bellouard, Ronan, additional, Asseray, Nathalie, additional, Lakhal, Karim, additional, and Boutoille, David, additional

Published
2019
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23. Development and validation of a dosing nomogram for amoxicillin in infective endocarditis.

Author

Rambaud, Antoine, Gaborit, Benjamin Jean, Deschanvres, Colin, Turnier, Paul Le, Lecomte, Raphaël, Asseray-Madani, Nathalie, Leroy, Anne-Gaëlle, Deslandes, Guillaume, Dailly, Éric, Jolliet, Pascale, Boutoille, David, Bellouard, Ronan, Gregoire, Matthieu, group, the Nantes Anti-Microbial Agents PK/PD (NAMAP) study, Le Turnier, Paul, and Nantes Anti-Microbial Agents PK/PD (NAMAP) study group

Subjects
INFECTIVE endocarditis, NOMOGRAPHY (Mathematics), BODY surface area, GLOMERULAR filtration rate, BLOOD proteins, AMOXICILLIN
Abstract

Background: Amoxicillin is the first-line treatment for streptococcal or enterococcal infective endocarditis (IE) with a dose regimen adapted to weight.Objectives: Covariates influencing pharmacokinetics (PK) of amoxicillin were identified in order to develop a dosing nomogram based on identified covariates for individual adaptation.Patients and Methods: Patients treated with amoxicillin administered by continuous infusion for IE were included retrospectively. The population PK analysis was performed using the Pmetrics package for R (NPAG algorithm). Influence of weight, ideal weight, height, BMI, body surface area, glomerular filtration rate adapted to the body surface area and calculated by the CKD-EPI method (mL/min), additional ceftriaxone treatment and serum protein level on amoxicillin PK was tested. A nomogram was then developed to determine the daily dose needed to achieve a steady-state free plasma concentration above 4× MIC, 100% of the time, without exceeding a total plasma concentration of 80 mg/L.Results: A total of 160 patients were included. Population PK analysis was performed on 540 amoxicillin plasma concentrations. A two-compartment model best described amoxicillin PK and the glomerular filtration rate covariate significantly improved the model when included in the calculation of the elimination constant Ke.Conclusions: This work allowed the development of a dosing nomogram that can help to increase achievement of the PK/pharmacodynamic targets in IE treated with amoxicillin. [ABSTRACT FROM AUTHOR]

Published
2020
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25. Prophylactic cefazolin concentrations in morbidly obese patients undergoing sleeve gastrectomy: do we achieve targets?

Author

Grégoire, Matthieu, primary, Dumont, Romain, additional, Ronchi, Ludovic, additional, Woillard, Jean-Baptiste, additional, Atthar, Vincent, additional, Letessier, Eric, additional, Cinotti, Raphaël, additional, Roquilly, Antoine, additional, Deslandes, Guillaume, additional, Jolliet, Pascale, additional, Asehnoune, Karim, additional, and Dailly, Eric, additional

Published
2018
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27. Pharmacokinetics of Tedizolid in an Obese Patient after Bariatric Surgery

Author

Grégoire, Matthieu, primary, Libois, Julia Brochard, additional, Waast, Denis, additional, Gaborit, Benjamin, additional, Dauty, Marc, additional, Deslandes, Guillaume, additional, Dailly, Eric, additional, Touchais, Sophie, additional, Boutoille, David, additional, Grégoire, Nicolas, additional, and Couet, William, additional

Published
2018
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28. Fungal Prophylaxis with a Gastro-Resistant Posaconazole Tablet for Patients with Hematological Malignancies in the POSANANTES Study

Author

Peterlin, Pierre, primary, Chauvin, Cécile, additional, Le Gouill, Steven, additional, Pere, Morgane, additional, Dalichampt, Marie, additional, Guillaume, Thierry, additional, Garnier, Alice, additional, Paré, Maxime, additional, Le Bourgeois, Amandine, additional, Moreau, Philippe, additional, Chevallier, Patrice, additional, Deslandes, Guillaume, additional, and Gastinne, Thomas, additional

Published
2018
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29. Should we reconsider cefazolin for treating staphylococcal meningitis? A retrospective analysis of cefazolin and cloxacillin cerebrospinal fluid levels in patients treated for staphylococcal meningitis

Author

Raffi, Francois, Boutoille, David, Biron, Charlotte, Lefebvre, Maeva, Gaborit, Benjamin Jean, Le Turnier, Paul, Deschanvres, Colin, Lecomte, Raphael, Chauveau, Marie, Asseray, Nathalie, Gregoire, Matthieu, Bellouard, Ronan, Deslandes, Guillaume, Dailly, Eric, Leroy, Anne-Gaëlle, Corvec, Stéphane, Bémer, Pascale, Caillon, Jocelyne, Guillouzouic, Aurélie, Lakhal, Karim, Cinotti, Raphaël, Canet, Emmanuel, Bretonniere, Cédric, Guimard, Thomas, Brochard, Julia, Talarmin, Jean Philippe, Katchatourian, Lydie, Le Turnier, P., Gregoire, M., Deslandes, G., Lakhal, K., Deschanvres, C., Lecomte, R., Talarmin, J.-P., Dubée, V., Bellouard, R., Boutoille, D., Leroy, A.-G., and Gaborit, B.J.

Published
2020
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31. 4-MEC et ChemSex : quatre cas dont un mortel

Author

Allard, Sophie, primary, Deslandes, Guillaume, additional, Visseaux, Guillaume, additional, Nicolet, Laurent, additional, Rabiller, Paule, additional, Victorri-Vigneau, Caroline, additional, Jolliet, Pascale, additional, and Monteil-Ganière, Catherine, additional

Published
2017
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32. Stability and Compatibility of Antibiotics in Peritoneal Dialysis Solutions Applied to Automated Peritoneal Dialysis in the Pediatric Population

Author

Deslandes, Guillaume, primary, Grégoire, Matthieu, additional, Bouquié, Régis, additional, Le Marec, Aude, additional, Allard, Sophie, additional, Dailly, Eric, additional, Pineau, Alain, additional, Allain-Launay, Emma, additional, Jolliet, Pascale, additional, Roussey, Gwenaëlle, additional, and Navas, Dominique, additional

Published
2016
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36. Cannabis intoxication after accidental ingestion in infants: urine and plasma concentrations of Δ-9-tetrahydrocannabinol (THC), THC-COOH and 11-OH-THC in 10 patients.

Author

Guidet, Charles, Gregoire, Matthieu, Le Dreau, Alexiane, Vrignaud, Benedicte, Deslandes, Guillaume, and Monteil-Ganière, Catherine

Subjects
MARIJUANA, INFANTS, URINE, SELF-poisoning, CANNABINOIDS, MASS spectrometry, INGESTION
Abstract

Introduction: Accidental cannabis poisoning after oral ingestion in infants is an emerging cause of intoxication with well-known clinical aspects but few data exist regarding the levels of cannabinoids in plasma and urine. Here, we present data on the concentrations of Δ-9-tetrahydrocannabinol (THC) and metabolites in plasma and/or urine in 10 infants after cannabis intoxication. Materials and methods: Cannabinoids were detected using an automated immunochemical method and quantified using liquid chromatography coupled with mass spectrometry. Results: Ten infants were admitted after cannabis poisoning. THC, THC-COOH and 11-OH-THC plasma levels ranged from 4.4 to 127 ng/mL, from 28 to 433 ng/mL and from 2 to 59.8 ng/mL, respectively. THC-COOH urine levels ranged from 748 to 5689 ng/mL. The most common symptoms were drowsiness, hypotonia, behavioural disorder and tachycardia. Discussion: No correlation between plasma concentrations and symptoms could be found, but the concentration of THC-COOH in the two patients who experienced seizures was higher than 3000 ng/mL. This series of cases of accidental intoxication in infants showed high THC and metabolites concentrations in urine and plasma. [ABSTRACT FROM AUTHOR]

Published
2020
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37. Status epilepticus following self-poisoning of lacosamide and lamotrigine: A case report with follow-up of drug serum concentrations

Author

Deslandes, Guillaume, primary, Bouquié, Regis, additional, Lorber, Julien, additional, Bruneau, Chloé, additional, Gregoire, Matthieu, additional, Grison-Hernando, Hélène, additional, Pineau, Alain, additional, Monteil-Ganière, Catherine, additional, Azoulay, Claudine, additional, Dailly, Eric, additional, Villers, Daniel, additional, Harry, Patrick, additional, and Jolliet, Pascale, additional

Published
2015
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38. Accidental poisoning with brimonidine eye drops in a 9-day-old infant

Author

Deslandes, Guillaume, primary, Bouquié, Regis, additional, Boels, David, additional, Gregoire, Matthieu, additional, Grison-Hernando, Hélène, additional, Azoulay, Claudine, additional, Pineau, Alain, additional, Monteil-Ganière, Catherine, additional, Renaud, Christian, additional, Dailly, Eric, additional, Harry, Patrick, additional, and Jolliet, Pascale, additional

Published
2015
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39. L’acidose lactique précoce lors de l’intoxication massive au paracétamol : un trouble métabolique parfois méconnu

Author

Grégoire, Matthieu, primary, Bretonniere, Cédric, additional, Deslandes, Guillaume, additional, Monteil-Ganiere, Catherine, additional, Bouquié, Régis, additional, Dailly, Eric, additional, Renaud, Christian, additional, Azoulay, Claudine, additional, Pineau, Alain, additional, Grison-Hernando, Hélène, additional, and Jolliet, Pascale, additional

Published
2015
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45. Virological response to darunavir in patients infected with HIV is linked to darunavir resistance-associated mutations corrected by the count of mutations with positive impact and is not associated with pharmacological and combined virological/pharmacolog

Author

Dailly, Eric, primary, Rodallec, Audrey, additional, Allavena, Clotilde, additional, Deslandes, Guillaume, additional, Garnier, Elisabeth, additional, Billaud, Eric, additional, Ferré, Virginie, additional, Reliquet, Véronique, additional, Bouquié, Régis, additional, Raffi, François, additional, and Jolliet, Pascale, additional

Published
2011
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47. High metabolic N-oxidation of voriconazole in a patient with refractory aspergillosis and CYP2C19* 17/* 17 genotype.

Author

Bennis, Youssef, Bodeau, Sandra, Bouquié, Régis, Deslandes, Guillaume, Verstuyft, Céline, Gruson, Bérangère, Andréjak, Michel, Lemaire‐Hurtel, Anne‐Sophie, and Chouaki, Taieb

Subjects
ASPERGILLOSIS, VORICONAZOLE
Abstract

A letter to the editor is presented on a case of high metabolic N-oxidation of voriconazole in a patient with refractory aspergillosis.

Published
2015
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48. A fast LC-MS/MS assay for methotrexate monitoring in plasma: validation, comparison to FPIA and application in the setting of carboxypeptidase therapy

Author

Bouquié, Régis, Deslandes, Guillaume, Nieto Bernáldez, Blanca, Renaud, Christian, Dailly, Eric, and Jolliet, Pascale

Abstract

High-dose methotrexate remains a mainstay in the treatment of acute lymphoblastic leukaemia, osteosarcoma and non-Hodgkin lymphoma. Therapeutic drug monitoring of plasma MTX is important to monitor efficacy and adverse events. The authors aimed at developing a liquid chromatography tandem mass spectrometry (LC-MS/MS) method with online extraction to determine MTX and 7-OH-MTX in plasma for therapeutic drug monitoring. The analysis combined straightforward sample preparation, consisting of protein precipitation with methanol/ZnSO4, with a 4-minute run time consisting of an on-line enrichment by a flush/back-flush cycle (Poros column, R1/20, 2.1 mm × 30 mm) before the second dimension chromatography (Phenomenex Luna 5 μm Phenyl Hexyl, 2 mm × 50 mm column). Samples were analysed using an HPLC Agilent 1200 Series and ABSciex API 3200. The electrospray was operated in positive ionization mode monitoring the following mass transitions: m/z455.11 → 308.3 for MTX, 471.14 → 324.3 for 7-OH-MTX and m/z459.1 → 312.3 for internal standard (MTX13C2H3). The method was linear up to 50 μmol L−1, and intra-day and inter-day quality control CVs were below 8.3% for MTX and 11.71% for 7-OH-MTX. Average recovery was 24% for MTX and 57% for 7-OH-MTX. The lower limit of quantitation was 25 nmol L−1for the 2 analytes. For MTX and 7-OH-MTX the standard line slope CV percentage was <3% and the slope difference <6%, indicating that our analytical method is almost free from a significant relative matrix effect. Method comparison with the Abbott TDx fluorescent polarization immunoassay (FPIA) showed excellent agreement: LC-MS/MS = 0.0011 + 1.0334 (FPIA). Because of antibody cross-reactivity between DAMPA and MTX, none of the immunoassays can be used after carboxypeptidase administration. The goal of our work was to develop a specific LC-MS/MS method to monitor both MTX and 7-OH-MTX plasma concentrations within the clinically relevant range. It's expected that the LC-MS/MS method for MTX monitoring after carboxypeptidase administration will be very rarely used since it concerns only exceptional cases. Therefore, the geographically balanced distribution of University Hospital able to ensure follow-up of these patients, within 24 hours of collection, can draw a reliable solution for the security of the patients. We develop a fast and reliable LC-MS/MS method for both routine TDM of MTX as in the setting of carboxypeptidase therapy.

Published
2013
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50. High-Dosage Cefazolin Achieves Sufficient Cerebrospinal Diffusion To Treat an External Ventricular Drainage-Related Staphylococcus aureusVentriculitis

Author

Grégoire, Matthieu, Gaborit, Benjamin, Deschanvres, Colin, Lecomte, Raphaël, Deslandes, Guillaume, Dailly, Éric, Ambrosi, Xavier, Bellouard, Ronan, Asseray, Nathalie, Lakhal, Karim, and Boutoille, David

Abstract

A patient received continuous infusion of cefazolin 10 g then 8 g daily for an external ventricular drainage-related methicillin-susceptible Staphylococcus aureus(MSSA) ventriculitis. Median free concentrations in the cerebrospinal fluid were 11.9 and 6.1 mg/liter after 10- and 8-g doses, respectively.

Published
2018
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