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2. Randomized Clinical Trial of High-Dose Rifampicin With or Without Levofloxacin Versus Standard of Care for Pediatric Tuberculous Meningitis: The TBM-KIDS Trial

Author

Paradkar, Mandar S, D, Bella Devaleenal, Mvalo, Tisungane, Arenivas, Ana, Thakur, Kiran T, Wolf, Lisa, Nimkar, Smita, Inamdar, Sadaf, Giridharan, Prathiksha, Selladurai, Elilarasi, Kinikar, Aarti, Valvi, Chhaya, Khwaja, Saltanat, Gadama, Daphne, Balaji, Sarath, Kattagoni, Krishna Yadav, Venkatesan, Mythily, Savic, Radojka, Swaminathan, Soumya, Gupta, Amita, Gupte, Nikhil, Mave, Vidya, Dooley, Kelly E, Agiwal, Shivali, Ahire, Rupali, Balasubramanian, Usha, Bendre, Manjushree, Chandane, Jyoti, Chopade, Kavita, Dalimbkar, Shamala, Deshpande, Prasad, Dhage, Rajendra, Ithape, Mahesh, Jadhav, Varsha, Kante, Sonali, Kapre, Pallavi, Khan, Nawshaba, Kulkarni, Vandana, Madewar, Renu, Meshram, Shashibhushan, Muttha, Kunal, Nadgeri, Vaishali, Nagargoje, Arti, Nagraj, Amita, Nijampurkar, Aparna, Onawale, Prerana, Pawar, Namrata, Pawar, Prashant, Pradhan, Neeta, Shaikh, Varsha, Shaikh, Zaheda, Shere, Dhananjay, Wani, Gouri, Kulkarni, Rajesh, Rajput, Uday, Ganesan, Mangalambal, Arasan, Gunasundari, Shankar, Shakila, Mary, S Stella, Karuppaiah, Sureshwari, Pauline, Leema, Pramila, Snegha Karunakaran, Arul, Priyadharshini, Ganesh, Sankar, Hanna, Luke Elizabeth, Ramesh, K, Kannan, M, Vijayakumar, Ruthra, Sivakumar, Surekha S, Devika, K, Radhakrishnan, A, Preethi, AR, Rajkumar, S, Saravanan, N, Ramachandran, Geetha, Kumar, AK Hemanth, Dharman, M, Sudha, V, Hissar, Syed, Nagarajan, Valarmathi, Jennifer, Linda, Supriya, R, Manimegalai, R, Kandan, Santhanam, Maniselvi, Archana, Puspha, Oli, Vaishnavi, S, Selvi, R, Neelakandan, Logeswari, Chiunda, Mary, Chunga, Moreen, Kamanga, Madalo, Kamthunzi, Portia, Kanthiti, Elizabeth, Mbewe, Abineli, Msiska, Emmie, Mumba, Noel, Phiri, Ian Zifa, Palichina, Victor, and Sichali, Dorothy

Subjects
Pediatric, Clinical Trials and Supportive Activities, Clinical Research, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Good Health and Well Being, Adult, Child, Humans, Rifampin, Tuberculosis, Meningeal, Levofloxacin, Ethambutol, Antitubercular Agents, Standard of Care, pediatric tuberculous meningitis, neuropsychological, clinical trial, levofloxacin, high-dose rifampicin, TuBerculous Meningitis in Kids (TBM-KIDS) Study Team, Biological Sciences, Medical and Health Sciences, Microbiology
Abstract

BackgroundPediatric tuberculous meningitis (TBM) commonly causes death or disability. In adults, high-dose rifampicin may reduce mortality. The role of fluoroquinolones remains unclear. There have been no antimicrobial treatment trials for pediatric TBM.MethodsTBM-KIDS was a phase 2 open-label randomized trial among children with TBM in India and Malawi. Participants received isoniazid and pyrazinamide plus: (i) high-dose rifampicin (30 mg/kg) and ethambutol (R30HZE, arm 1); (ii) high-dose rifampicin and levofloxacin (R30HZL, arm 2); or (iii) standard-dose rifampicin and ethambutol (R15HZE, arm 3) for 8 weeks, followed by 10 months of standard treatment. Functional and neurocognitive outcomes were measured longitudinally using Modified Rankin Scale (MRS) and Mullen Scales of Early Learning (MSEL).ResultsOf 2487 children prescreened, 79 were screened and 37 enrolled. Median age was 72 months; 49%, 43%, and 8% had stage I, II, and III disease, respectively. Grade 3 or higher adverse events occurred in 58%, 55%, and 36% of children in arms 1, 2, and 3, with 1 death (arm 1) and 6 early treatment discontinuations (4 in arm 1, 1 each in arms 2 and 3). By week 8, all children recovered to MRS score of 0 or 1. Average MSEL scores were significantly better in arm 1 than arm 3 in fine motor, receptive language, and expressive language domains (P

Published
2022

11. Elevated highly sensitive C-reactive protein and d-dimer levels are associated with food insecurity among people living with HIV in Pune, India.

Author

Patil, Sandesh, Kadam, Dileep, Mehtani, Nicky, Sangle, Shashikala, Marbaniang, Ivan, Kulkarni, Vandana, Shere, Dhananjay, Deshpande, Prasad, Dhumal, Gauri, Suryavanshi, Nishi, Gupte, Nikhil, Bollinger, Robert, DeLuca, Andrea, Nevrekar, Neetal, Menon, Pramila, Kawade, Rama, Patil, Mansi, Gupta, Amita, and Mave, Vidya

Subjects
d-Dimer, Food insecurity, HIV, High-sensitivity C-reactive protein, India, Adult, C-Reactive Protein, Cross-Sectional Studies, Female, Fibrin Fibrinogen Degradation Products, Food Supply, HIV Infections, Humans, India, Male, Middle Aged, Young Adult
Abstract

OBJECTIVE: To assess the prevalence and determinants of food insecurity among people living with HIV (PLWH) in Pune, India and its association with biomarkers known to confer increased risks of morbidity and mortality in this population. DESIGN: Cross-sectional analysis assessing food insecurity using the standardized Household Food Insecurity Access Scale. Participants were dichotomized into two groups: food insecure and food secure. Logistic regression models were used to assess associations between socio-economic, demographic, clinical, biochemical factors and food insecurity. SETTING: Antiretroviral therapy (ART) centre of Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals (BJGMC-SGH), Pune, a large publicly funded tertiary and teaching hospital in western India.ParticpantsAdult (≥18 years) PLWH attending the ART centre between September 2015 and May 2016 who had received ART for either ≤7d (ART-naïve) or ≥1 year (ART-experienced). RESULTS: Food insecurity was reported by 40 % of 483 participants. Independent risk factors (adjusted OR; 95 % CI) included monthly family income

Published
2019

14. Study of Temporal Behaviour of Homogeneity Maps for Estimating Representative Area of a Ground Sample Using Remote Sensing

Author

Deshpande, Prasad J., Sure, Anudeep, Dikshit, Onkar, Tripathi, Shivam, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Bhuiyan, Chandrashekhar, editor, Flügel, Wolfgang-Albert, editor, and Jain, Sharad Kumar, editor

Published
2021
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20. Intensified Short Symptom Screening Program for Dengue Infection during Pregnancy, India

Author

Naik, Shilpa, Robinson, Matthew L., Alexander, Mallika, Chandanwale, Ajay, Sambarey, Pradip, Kinikar, Aarti, Bharadwaj, Renu, Sapkal, Gajanan N., Chebrolu, Puja, Deshpande, Prasad, Kulkarni, Vandana, Nimkar, Smita, Mave, Vidya, Gupta, Amita, and Mathad, Jyoti

Subjects
Conjunctivitis -- Diagnosis, Dengue fever -- Diagnosis, Pregnancy, Pregnant women, Time, Polymerase chain reaction, Malaria, Intelligence gathering, Rash, Women, Diseases, Health
Abstract

Every year, an estimated 96 million persons worldwide are given a clinical diagnosis of severe dengue infection (1). In 2017, a total of 188,401 cases of dengue were diagnosed in [...]

Published
2020
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21. Collusion-Resistant Processing of SQL Range Predicates

Author

Kesarwani, Manish, Kaul, Akshar, Singh, Gagandeep, Deshpande, Prasad M., Haritsa, Jayant R., Hutchison, David, Editorial Board Member, Kanade, Takeo, Editorial Board Member, Kittler, Josef, Editorial Board Member, Kleinberg, Jon M., Editorial Board Member, Mattern, Friedemann, Editorial Board Member, Mitchell, John C., Editorial Board Member, Naor, Moni, Editorial Board Member, Pandu Rangan, C., Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Terzopoulos, Demetri, Editorial Board Member, Tygar, Doug, Editorial Board Member, Weikum, Gerhard, Series Editor, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Pei, Jian, editor, Manolopoulos, Yannis, editor, Sadiq, Shazia, editor, and Li, Jianxin, editor

Published
2018
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25. Advanced Operators for Similarity Search

Author

P, Deepak, Deshpande, Prasad M., Zdonik, Stan, Series editor, Shekhar, Shashi, Series editor, Katz, Jonathan, Series editor, Wu, Xindong, Series editor, Jain, Lakhmi C., Series editor, Padua, David, Series editor, Shen, Xuemin (Sherman), Series editor, Furht, Borko, Series editor, Subrahmanian, VS, Series editor, Hebert, Martial, Series editor, Ikeuchi, Katsushi, Series editor, Siciliano, Bruno, Series editor, Jajodia, Sushil, Series editor, Lee, Newton, Series editor, P, Deepak, and Deshpande, Prasad M.

Published
2015
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26. The Road Ahead

Author

P, Deepak, Deshpande, Prasad M., Zdonik, Stan, Series editor, Shekhar, Shashi, Series editor, Katz, Jonathan, Series editor, Wu, Xindong, Series editor, Jain, Lakhmi C., Series editor, Padua, David, Series editor, Shen, Xuemin (Sherman), Series editor, Furht, Borko, Series editor, Subrahmanian, VS, Series editor, Hebert, Martial, Series editor, Ikeuchi, Katsushi, Series editor, Siciliano, Bruno, Series editor, Jajodia, Sushil, Series editor, Lee, Newton, Series editor, P, Deepak, and Deshpande, Prasad M.

Published
2015
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27. Common Similarity Search Operators

Author

P, Deepak, Deshpande, Prasad M., Zdonik, Stan, Series editor, Shekhar, Shashi, Series editor, Katz, Jonathan, Series editor, Wu, Xindong, Series editor, Jain, Lakhmi C., Series editor, Padua, David, Series editor, Shen, Xuemin (Sherman), Series editor, Furht, Borko, Series editor, Subrahmanian, VS, Series editor, Hebert, Martial, Series editor, Ikeuchi, Katsushi, Series editor, Siciliano, Bruno, Series editor, Jajodia, Sushil, Series editor, Lee, Newton, Series editor, P, Deepak, and Deshpande, Prasad M.

Published
2015
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28. Indexing for Similarity Search Operators

Author

P, Deepak, Deshpande, Prasad M., Zdonik, Stan, Series editor, Shekhar, Shashi, Series editor, Katz, Jonathan, Series editor, Wu, Xindong, Series editor, Jain, Lakhmi C., Series editor, Padua, David, Series editor, Shen, Xuemin (Sherman), Series editor, Furht, Borko, Series editor, Subrahmanian, VS, Series editor, Hebert, Martial, Series editor, Ikeuchi, Katsushi, Series editor, Siciliano, Bruno, Series editor, Jajodia, Sushil, Series editor, Lee, Newton, Series editor, P, Deepak, and Deshpande, Prasad M.

Published
2015
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29. Fundamentals of Similarity Search

Author

P, Deepak, Deshpande, Prasad M., Zdonik, Stan, Series editor, Shekhar, Shashi, Series editor, Katz, Jonathan, Series editor, Wu, Xindong, Series editor, Jain, Lakhmi C., Series editor, Padua, David, Series editor, Shen, Xuemin (Sherman), Series editor, Furht, Borko, Series editor, Subrahmanian, VS, Series editor, Hebert, Martial, Series editor, Ikeuchi, Katsushi, Series editor, Siciliano, Bruno, Series editor, Jajodia, Sushil, Series editor, Lee, Newton, Series editor, P, Deepak, and Deshpande, Prasad M.

Published
2015
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30. Introduction

Author

P, Deepak, Deshpande, Prasad M., Zdonik, Stan, Series editor, Shekhar, Shashi, Series editor, Katz, Jonathan, Series editor, Wu, Xindong, Series editor, Jain, Lakhmi C., Series editor, Padua, David, Series editor, Shen, Xuemin (Sherman), Series editor, Furht, Borko, Series editor, Subrahmanian, VS, Series editor, Hebert, Martial, Series editor, Ikeuchi, Katsushi, Series editor, Siciliano, Bruno, Series editor, Jajodia, Sushil, Series editor, Lee, Newton, Series editor, P, Deepak, and Deshpande, Prasad M.

Published
2015
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31. Categorizing Operators

Author

P, Deepak, Deshpande, Prasad M., Zdonik, Stan, Series editor, Shekhar, Shashi, Series editor, Katz, Jonathan, Series editor, Wu, Xindong, Series editor, Jain, Lakhmi C., Series editor, Padua, David, Series editor, Shen, Xuemin (Sherman), Series editor, Furht, Borko, Series editor, Subrahmanian, VS, Series editor, Hebert, Martial, Series editor, Ikeuchi, Katsushi, Series editor, Siciliano, Bruno, Series editor, Jajodia, Sushil, Series editor, Lee, Newton, Series editor, P, Deepak, and Deshpande, Prasad M.

Published
2015
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32. Association of Pregnancy and HIV Status with Molecular-Bacterial Vaginosis in Indian Women

Author

Tuddenham, Susan, primary, Shafiq, Mehr, additional, Mathad, Jyoti S., additional, Alexander, Mallika, additional, Naik, Shilpa, additional, Kulkarni, Vandana, additional, Deshpande, Prasad, additional, Humphrys, Mike S., additional, Holm, Johanna B., additional, Khan, Nawshaba, additional, Yadana, Su, additional, Cheedalla, Aneesha, additional, Bhosale, Ramesh, additional, Ghanem, Khalil G., additional, Wang, Tian, additional, Wang, Shuang, additional, Ma, Bing, additional, Ravel, Jacques, additional, Gupta, Amita, additional, and Shivakoti, Rupak, additional

Published
2023
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36. Design and Development of Efficient Synthetic Strategies for Novel B-Lactam Enhancer Wck 5153 Effective Against Gram-Negative Pathogens

Author

Bhavsar, Satishkumar Baliram, primary, Pawar, Shivaji, additional, Joshi, Sanjeev, additional, Jadhav, Sunil, additional, Mishra, Amit, additional, Dond, Bharat, additional, Kayastha, Abhijeet K., additional, Yeole, Ravindra, additional, Deshpande, Prasad, additional, Bhagwat, Sachin, additional, and Patel, Mahesh, additional

Published
2023
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39. Improving Recall of Regular Expressions for Information Extraction

Author

Murthy, Karin, P., Deepak, Deshpande, Prasad M., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Wang, X. Sean, editor, Cruz, Isabel, editor, Delis, Alex, editor, and Huang, Guangyan, editor

Published
2012
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40. WYSIWYE: An Algebra for Expressing Spatial and Textual Rules for Information Extraction

Author

Chenthamarakshan, Vijil, Varadarajan, Ramakrishna, Deshpande, Prasad M., Krishnapuram, Raghuram, Stolze, Knut, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Gao, Hong, editor, Lim, Lipyeow, editor, Wang, Wei, editor, Li, Chuan, editor, and Chen, Lei, editor

Published
2012
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43. Smokeless tobacco use and oral potentially malignant disorders among people living with HIV (PLHIV) in Pune, India: Implications for oral cancer screening in PLHIV

Author

Marbaniang, Ivan, primary, Joshi, Samir, additional, Sangle, Shashikala, additional, Khaire, Samir, additional, Thakur, Rahul, additional, Chavan, Amol, additional, Gupte, Nikhil, additional, Kulkarni, Vandana, additional, Deshpande, Prasad, additional, Nimkar, Smita, additional, and Mave, Vidya, additional

Published
2022
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49. Clinical and Immunological Markers of Pulmonary Impairment Among People With HIV in India

Author

Baidya, Anurima, primary, Sangle, Shashikala, additional, Marbaniang, Ivan, additional, Kulkarni, Vandana, additional, Deshpande, Prasad, additional, Nimkar, Smita, additional, Chavan, Amol, additional, Salvi, Sonali, additional, Lokhande, Rahul, additional, Kadam, Dileep, additional, Gupta, Amita, additional, Mave, Vidya, additional, and Gupte, Akshay N, additional

Published
2022
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50. Levonadifloxacin, a Novel Broad-Spectrum Anti-MRSA Benzoquinolizine Quinolone Agent: Review of Current Evidence

Author

Bhagwat, Sachin S, Nandanwar, Manohar, Kansagara, Atul, Patel, Anusuya, Takalkar, Swapna, Chavan, Rajesh, Periasamy, Hariharan, Yeole, Ravindra, Deshpande, Prasad K, Bhavsar, Satish, Bhatia, Ashima, Ahdal, Jaishid, Jain, Rishi, and Patel, Mahesh

Subjects
broad -spectrum antibiotic, Methicillin-Resistant Staphylococcus aureus, Molecular Structure, Review, MRSA, Microbial Sensitivity Tests, alalevonadifloxacin, Quinolones, levonadifloxacin, Anti-Bacterial Agents, WCK 771, Animals, Humans, WCK 2349, Quinolizines
Abstract

Levonadifloxacin and its prodrug alalevonadifloxacin are novel broad-spectrum anti-MRSA agents belonging to the benzoquinolizine subclass of quinolone, formulated for intravenous and oral administration, respectively. Various in vitro and in vivo studies have established their antimicrobial spectrum against clinically significant Gram-positive, Gram-negative, atypical, and anaerobic pathogens. The potent activity of levonadifloxacin against MRSA, quinolone-resistant Staphylococcus aureus, and hetero-vancomycin-intermediate strains is an outcome of its well-differentiated mechanism of action involving preferential targeting to DNA gyrase. Potent anti-staphylococcal activity of levonadifloxacin was also observed in clinically relevant experimental conditions such as acidic pH, the intracellular environment, and biofilms, suggesting that the drug is bestowed with enabling features for the treatment of difficult-to-treat MRSA infections. Levonadifloxacin also retains clinically relevant activity against resistant respiratory pathogens such as macrolide- and penicillin-resistant Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, and Moraxella catarrhalis and, in conjunction with clinically established best-in-class human epithelial lung fluid concentration, has promising potential in the management of recalcitrant respiratory infections. Attractive features, such as resistance to NorA efflux, divergent mechanism of action in S. aureus, cidality against high-inoculum cultures, and low mutant prevention concentration, are likely to confer favorable resistance-suppression features to both agents. In vivo studies have shown promising efficacy in models of acute bacterial skin and skin structure infection, respiratory infections, pyelonephritis, and peritonitis at human-equivalent mouse doses. Both formulations were well tolerated in multiple phase I studies and overall showed a dose-dependent exposure. In particular, oral alalevonadifloxacin showed excellent bioavailability (~90%), almost mirroring the pharmacokinetic profile of intravenous levonadifloxacin, indicating the prodrug’s seamless absorption and efficient cleavage to release the active parent drug. Hepatic impairment studies showed that clinical doses of levonadifloxacin/alalevonadifloxacin are not required to be adjusted for various degrees of hepatic impairment. With the successful completion of phase II and phase III studies for both levonadifloxacin and alalevonadifloxacin, they represent clinically attractive therapeutic options for the treatment of infections caused by multi-drug-resistant Gram-positive organisms. Herein, we review the current evidence on therapeutically appealing attributes of levonadifloxacin and alalevonadifloxacin, which are based on a range of non-clinical in vitro and in vivo investigations and clinical studies.

Published
2019

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