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25 results on '"Deshidi Ramesh"'

1. Supplementary Figure 1 from Secalonic Acid-D Represses HIF1α/VEGF-Mediated Angiogenesis by Regulating the Akt/mTOR/p70S6K Signaling Cascade

Author

Shashi Bhushan, R.A. Vishwakarma, A.K. Saxena, Abdul Faruk, Surrinder K. Lattoo, Sheikh Abdullah Tasduq, Bhahwal Ali Shah, J.P. Sharma, Sundeep Jaglan, B.K. Chandan, P.R. Sharma, Fayaz Malik, Ajay Kumar, Satiander Rana, Manjeet Kumar, Deshidi Ramesh, Suresh Kumar, Anup Singh Pathania, and Santosh Kumar Guru

Abstract

Supplementary Figure 1. Molecular structure and cytotoxic profile of secalonic acid D (SAD). Colony morphology, Neighbor-joining rooted tree and sequencing of fungal endophyte (EF-VR2).

Published
2023
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2. Supplementary Material 1 from Secalonic Acid-D Represses HIF1α/VEGF-Mediated Angiogenesis by Regulating the Akt/mTOR/p70S6K Signaling Cascade

Author

Shashi Bhushan, R.A. Vishwakarma, A.K. Saxena, Abdul Faruk, Surrinder K. Lattoo, Sheikh Abdullah Tasduq, Bhahwal Ali Shah, J.P. Sharma, Sundeep Jaglan, B.K. Chandan, P.R. Sharma, Fayaz Malik, Ajay Kumar, Satiander Rana, Manjeet Kumar, Deshidi Ramesh, Suresh Kumar, Anup Singh Pathania, and Santosh Kumar Guru

Abstract

Supplementary Material 1. DETAILS OF ANTIBODIES USED IN THE STUDY

Published
2023
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3. Supplementary Figure 2 from Secalonic Acid-D Represses HIF1α/VEGF-Mediated Angiogenesis by Regulating the Akt/mTOR/p70S6K Signaling Cascade

Author

Shashi Bhushan, R.A. Vishwakarma, A.K. Saxena, Abdul Faruk, Surrinder K. Lattoo, Sheikh Abdullah Tasduq, Bhahwal Ali Shah, J.P. Sharma, Sundeep Jaglan, B.K. Chandan, P.R. Sharma, Fayaz Malik, Ajay Kumar, Satiander Rana, Manjeet Kumar, Deshidi Ramesh, Suresh Kumar, Anup Singh Pathania, and Santosh Kumar Guru

Abstract

Supplementary Figure 2. Schematic presentation of mechanism of action of SAD.

Published
2023
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4. Supplementary Material 2 from Secalonic Acid-D Represses HIF1α/VEGF-Mediated Angiogenesis by Regulating the Akt/mTOR/p70S6K Signaling Cascade

Author

Shashi Bhushan, R.A. Vishwakarma, A.K. Saxena, Abdul Faruk, Surrinder K. Lattoo, Sheikh Abdullah Tasduq, Bhahwal Ali Shah, J.P. Sharma, Sundeep Jaglan, B.K. Chandan, P.R. Sharma, Fayaz Malik, Ajay Kumar, Satiander Rana, Manjeet Kumar, Deshidi Ramesh, Suresh Kumar, Anup Singh Pathania, and Santosh Kumar Guru

Abstract

Supplementary Material 2. DETAILS OF PRIMERS USED IN THE STUDY

Published
2023
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10. Secalonic Acid-D Represses HIF1α/VEGF-Mediated Angiogenesis by Regulating the Akt/mTOR/p70S6K Signaling Cascade

Author

Ajay Kumar, Ram A. Vishwakarma, Suresh Kumar, Santosh Kumar Guru, Punita Sharma, Bhahwal Ali Shah, Abdul Faruk, Satiander Rana, Sheikh A. Tasduq, Anil K. Saxena, Sundeep Jaglan, Jai Parkash Sharma, Fayaz Malik, Manjeet Kumar, B.K. Chandan, Deshidi Ramesh, Surrinder K. Lattoo, Anup Singh Pathania, and Shashi Bhushan

Subjects
Vascular Endothelial Growth Factor A, Cancer Research, Angiogenesis, Xanthones, Down-Regulation, Pharmacology, Biology, Neovascularization, chemistry.chemical_compound, Mice, medicine, Human Umbilical Vein Endothelial Cells, Animals, Humans, Protein kinase B, Microvessel, PI3K/AKT/mTOR pathway, Cells, Cultured, Neovascularization, Pathologic, TOR Serine-Threonine Kinases, Ribosomal Protein S6 Kinases, 70-kDa, Perifosine, Hypoxia-Inducible Factor 1, alpha Subunit, Mice, Inbred C57BL, Oncology, chemistry, Apoptosis, MCF-7 Cells, medicine.symptom, Secalonic acid, Proto-Oncogene Proteins c-akt, Signal Transduction
Abstract

Tumor angiogenesis is a validated target for therapeutic intervention, but agents that are more disease selective are needed. Here, we report the isolation of secalonic acid-D (SAD), a mycotoxin from a novel source that exhibits potent antiangiogenic antitumor activity. SAD inhibited multiple HIF1α/VEGF-arbitrated angiogenesis dynamics as scored in human umbilical vascular endothelial cells and human MCF-7 breast tumor xenografts. Similarly, SAD suppressed VEGF-induced microvessel sprouting from rat aortic ring and blood vessel formation in the Matrigel plug assay in C57/BL6J mice. Under normoxic or hypoxic conditions, SAD inhibited cell survival through the Akt/mTOR/p70S6K pathway, with attendant effects on key proangiogenesis factors, including HIF1α, VEGFR, and MMP-2/MMP-9. These effects were reversed by cotreatment with the Akt inhibitors perifosine and GSK69069 or by the addition of neutralizing VEGF antibodies. The apoptotic properties of SAD were determined to be both extrinsic and intrinsic in nature, whereas the cell-cycle inhibitory effects were mediated by altering the level of key G1–S transition-phase proteins. In experimental mouse models of breast cancer, SAD dosing produced no apparent toxicities (either orally or intraperitoneal) at levels that yielded antitumor effects. Taken together, our findings offered a preclinical validation and mechanistic definition of the antiangiogenic activity of a novel mycotoxin, with potential application as a cancer-selective therapeutic agent. Cancer Res; 75(14); 2886–96. ©2015 AACR.

Published
2014

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