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6 results on '"Deshayes, Chloé"'

1. Microbial-Host Co-metabolites Are Prodromal Markers Predicting Phenotypic Heterogeneity in Behavior, Obesity, and Impaired Glucose Tolerance

Author

Dumas, Marc-Emmanuel, Rothwell, Alice R., Hoyles, Lesley, Aranias, Thomas, Chilloux, Julien, Calderari, Sophie, Noll, Elisa M., Péan, Noémie, Boulangé, Claire L., Blancher, Christine, Barton, Richard H., Gu, Quan, Fearnside, Jane F., Deshayes, Chloé, Hue, Christophe, Scott, James, Nicholson, Jeremy K., and Gauguier, Dominique

Published
2017
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5. Image et consommation de sucre en France : constantes et paradoxes.

Author

DESHAYES, Chloé

Subjects
NUTRITION surveys, ADULTS, COVID-19, PRODUCT image, STAY-at-home orders
Abstract

Copyright of Industries Agro-Alimentaires (IAA) is the property of Ste Ad hoc and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2021

6. Microbial-host co-metabolites are prodromal markers predicting phenotypic heterogeneity in behavior, obesity, and impaired glucose tolerance

Author

Hoyles, Lesley, Aranias, Thomas, Chilloux, Julien, Calderari, Sophie, Noll, Elisa M., Péan, Noémie, Boulangé, Claire L., Blancher, Christine, Barton, Richard H., Gu, Quan, Fearnside, Jane F., Deshayes, Chloé, Hue, Christophe, Scott, James, Nicholson, Jeremy K, Gauguier, Dominique, Dumas, Marc-Emmanuel, and Rothwell, Alice R.

Subjects
anxiete, obésité, sécrétion d'insuline, TMAO, anxiety, endoplasmic reticulum stress, impaired glucose tolerance, insulin secretion, metabolome, microbiome, natural phenotypic variation, obesity, transcriptome, trimethylamine-N-oxide, Biologie du développement, Development Biology
Abstract

The influence of the gut microbiome on metabolic and behavioral traits is widely accepted, though the microbiome-derived metabolites involved remain unclear. We carried out untargeted urine (1)H-NMR spectroscopy-based metabolic phenotyping in an isogenic C57BL/6J mouse population (n = 50) and show that microbial-host co-metabolites are prodromal (i.e., early) markers predicting future divergence in metabolic (obesity and glucose homeostasis) and behavioral (anxiety and activity) outcomes with 94%-100% accuracy. Some of these metabolites also modulate disease phenotypes, best illustrated by trimethylamine-N-oxide (TMAO), a product of microbial-host co-metabolism predicting future obesity, impaired glucose tolerance (IGT), and behavior while reducing endoplasmic reticulum stress and lipogenesis in 3T3-L1 adipocytes. Chronic in vivo TMAO treatment limits IGT in HFD-fed mice and isolated pancreatic islets by increasing insulin secretion. We highlight the prodromal potential of microbial metabolites to predict disease outcomes and their potential in shaping mammalian phenotypic heterogeneity.

Published
2017

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