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267 results on '"Descotes, J.-L."'

7. MRI/TRUS data fusion for brachytherapy

Author

Daanen, V., Gastaldo, J., Giraud, J. Y., Fourneret, P., Descotes, J. L., Bolla, M., Collomb, D., and Troccaz, Jocelyne

Subjects
Computer Science - Other Computer Science
Abstract

BACKGROUND: Prostate brachytherapy consists in placing radioactive seeds for tumour destruction under transrectal ultrasound imaging (TRUS) control. It requires prostate delineation from the images for dose planning. Because ultrasound imaging is patient- and operator-dependent, we have proposed to fuse MRI data to TRUS data to make image processing more reliable. The technical accuracy of this approach has already been evaluated. METHODS: We present work in progress concerning the evaluation of the approach from the dosimetry viewpoint. The objective is to determine what impact this system may have on the treatment of the patient. Dose planning is performed from initial TRUS prostate contours and evaluated on contours modified by data fusion. RESULTS: For the eight patients included, we demonstrate that TRUS prostate volume is most often underestimated and that dose is overestimated in a correlated way. However, dose constraints are still verified for those eight patients. CONCLUSIONS: This confirms our initial hypothesis.

Published
2007
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10. A multicentric study on accurate grading of prostate cancer with systematic and MRI/US fusion targeted biopsies: comparison with final histopathology after radical prostatectomy

Author

Diamand, R., Oderda, M., Al Hajj Obeid, W., Albisinni, S., Van Velthoven, R., Fasolis, G., Simone, G., Ferriero, M., Roche, J-B., Piechaud, T., Pastore, A., Carbone, A., Fiard, G., Descotes, J-L., Marra, G., Gontero, P., Altobelli, E., Papalia, R., Kumar, P., Eldred-Evans, D., Giacobbe, A., Muto, G., Lacetera, V., Beatrici, V., Roumeguere, T., and Peltier, A.

Published
2019
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34. The potential prognostic role of pre-biopsy MRI: An example with PIRADS 5 lesions

Author

Fiard, G., primary, Seigneurin, A., additional, Ploussard, G., additional, Diamand, R., additional, Assenmacher, G., additional, Peltier, A., additional, Oderda, M., additional, Gontero, P., additional, Roumeguere, T., additional, Albisinni, S., additional, Dariane, C., additional, Barry Delongchamps, N., additional, Anract, J., additional, Van Damme, J., additional, Feyaerts, A., additional, Saussez, T., additional, Mastroianni, R., additional, Simone, G., additional, Fourcade, A., additional, Fournier, G., additional, Roumiguie, M., additional, and Descotes, J-L., additional

Published
2021
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39. Elastic fusion biopsy versus systematic biopsy for prostate cancer detection: Results of a multicentric study on 1,119 patients

Author

Oderda, M., Marra, G., Albisinni, S., Altobelli, E., Baco, E., Beatrici, V., Dellabella, M., Descotes, J. L., Eldred-Evans, D., Fasolis, G., Ferriero, M., Fiard, G., Giacobbe, A., Kumar, P., Lacetera, V., Mozer, P., Muto, G., Papalia, R., Peltier, A., Piechaud, T., Pierangeli, T., Simone, G., Roche, J. B., Roupret, M., and Gontero, P.

Subjects
Koelis, Systematic, Adult, Aged, 80 and over, Image-Guided Biopsy, Male, Prostate, Prostatic Neoplasms, Targeted, Fusion biopsy, Middle Aged, Accuracy, Elastic, Aged, Humans, Retrospective Studies, 80 and over
Abstract

To assess the accuracy of targeted and systematic biopsies for the detection of prostate cancer (PCa) and clinically significant PCa (csPCa) in the everyday practice, evaluating the need for additional systematic biopsies at the time of targeted biopsy.From our multicentric database gathering data on 2,115 patients who underwent fusion biopsy with Koelis™ system between 2010 and 2017, we selected 1,119 patients who received targeted biopsies (a median of 3 for each target), followed by systematic sampling of the prostate (12 to 14 cores). Overall and clinically significant cancer detection rate (CDR) of Koelis™ fusion biopsies were assessed, comparing target and systematic biopsies. Secondary endpoint was the identification of predictors of PCa detection.The CDR of targeted biopsies only was 48% for all cancers and 33% for csPCa. The performance of additional, systematic prostate sampling improved the CDR of 15% for all cancers and of 12% for csPCa. PCa was detected in 35%, 69%, and 92% of patients with lesions scored as PI-RADS 3, 4 and 5, respectively. Elevated PI-RADS score and positive digital rectal examination were predictors of PCa, whereas biopsy-naïve status was associated with csPCa.In the everyday practice target biopsy with Koelis™ achieves a good CDR for all PCa and csPCa, which is significantly improved by subsequent systematic sampling of the prostate. The outstanding outcomes of fusion biopsy are confirmed also in biopsy-naïve patients. Elevated PI-RADS score and positive digital rectal examination are strongly associated with presence of PCa.

Published
2018

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