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1. Posttraumatic stress disorder 2 months after cesarean delivery: a multicenter prospective study

Author

Sentilhes, Loïc, Senat, Marie V., Le Lous, Maëla, Winer, Norbert, Rozenberg, Patrick, Kayem, Gilles, Verspyck, Eric, Fuchs, Florent, Azria, Elie, Gallot, Denis, Korb, Diane, Desbrière, Raoul, Le Ray, Camille, Chauleur, Céline, de Marcillac, Fanny, Perrotin, Franck, Parant, Olivier, Salomon, Laurent J., Gauchotte, Emilie, Bretelle, Florence, Sananès, Nicolas, Bohec, Caroline, Mottet, Nicolas, Legendre, Guillaume, Letouzey, Vincent, Haddad, Bassam, Vardon, Delphine, Madar, Hugo, Mattuizzi, Aurélien, Froeliger, Alizée, Daniel, Valérie, Regueme, Sophie, Roussillon, Caroline, Bénard, Antoine, Georget, Aurore, Darsonval, Astrid, Deneux-Tharaux, Catherine, and Loussert, Lola

Published
2024
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2. Impact of discontinuing oxytocin in active labour on neonatal morbidity: an open-label, multicentre, randomised trial

Author

Girault, Aude, Sentilhes, Loïc, Desbrière, Raoul, Berveiller, Paul, Korb, Diane, Bertholdt, Charline, Carrara, Julie, Winer, Norbert, Verspyck, Eric, Boudier, Eric, Barjat, Tiphaine, Levy, Gilles, Roth, Georges Emmanuel, Kayem, Gilles, Massoud, Mona, Bohec, Caroline, Guerby, Paul, Azria, Elie, Blanc, Julie, Heckenroth, Hélène, Rousseau, Jessica, Garabedian, Charles, and Le Ray, Camille

Published
2023
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3. Tranexamic acid for reduction of blood loss after Caesarean delivery: a cost-effectiveness analysis of the TRAAP2 trial

Author

Senat, Marie-Victoire, Le Lous, Maëla, Winer, Norbert, Rozenberg, Patrick, Kayem, Gilles, Verspyck, Eric, Fuchs, Florent, Azria, Elie, Gallot, Denis, Korb, Diane, Desbrière, Raoul, Le Ray, Camille, Chauleur, Céline, de Marcillac, Fanny, Perrotin, Franck, Parant, Olivier, Salomon, Laurent J., Gauchotte, Emilie, Bretelle, Florence, Sananès, Nicolas, Bohec, Caroline, Mottet, Nicolas, Legendre, Guillaume, Letouzey, Vincent, Haddad, Bassam, Vardon, Delphine, Madar, Hugo, Froeliger, Alizée, Daniel, Valérie, Pharm.D, Regueme, Sophie, Roussillon, Caroline, Darsonval, Astrid, Sentilhes, Loïc, Bénard, Antoine, Petit, Solène, and Deneux-Tharaux, Catherine

Published
2023
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4. Closed- or open-glottis pushing for vaginal delivery: a planned secondary analysis of the TRAnexamic Acid for Preventing postpartum hemorrhage after vaginal delivery study

Author

Sentilhes, Loïc, Winer, Norbert, Azria, Elie, Sénat, Marie Victoire, Le Ray, Camille, Vardon, Delphine, Perrotin, Franck, Desbrière, Raoul, Fuchs, Florent, Kayem, Gilles, Ducarme, Guillaume, Doret-Dion, Muriel, Huissoud, Cyril, Bohec, Caroline, Deruelle, Philippe, Darsonval, Astrid, Chrétien, Jean-Marie, Seco, Aurélien, Daniel, Valérie, Deneux-Tharaux, Catherine, Froeliger, Alizée, Madar, Hugo, and Bouchghoul, Hanane

Published
2024
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5. 78 Foley catheter+oral misoprostol versus misoprostol for cervical ripening in nulliparous-obese women: a French multicenter RCT

Author

Guerby, Paul, primary, Berveiller, Paul, additional, Garabedian, Charles, additional, SENTILHES, Loïc, additional, Perrotin, Franck, additional, Winer, Norbert, additional, Vivanti, Alexandre, additional, Chauleur, Céline, additional, Boukerrou, Malik, additional, Fuchs, Florent, additional, Abossolo, Thierry, additional, Gallot, Denis, additional, Senat, Marie Victoire, additional, Desbriere, Raoul, additional, Letouzey, Vincent, additional, Azria, Elie, additional, Pierre, Fabrice, additional, Olivier-Abbal, Pascale, additional, Cassan, Perrine, additional, Arnaud, Catherine, additional, Devlamynck, Laure, additional, and Vayssiere, Christophe, additional

Published
2024
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7. A snapshot of the Covid-19 pandemic among pregnant women in France

Author

Kayem, Gilles, Lecarpentier, Edouard, Deruelle, Philippe, Bretelle, Florence, Azria, Elie, Blanc, Julie, Bohec, Caroline, Bornes, Marie, Ceccaldi, Pierre-François, Chalet, Yasmine, Chauleur, Céline, Cordier, Anne-Gael, Desbrière, Raoul, Doret, Muriel, Dreyfus, Michel, Driessen, Marine, Fermaut, Marion, Gallot, Denis, Garabédian, Charles, Huissoud, Cyril, Luton, Dominique, Morel, Olivier, Perrotin, Franck, Picone, Olivier, Rozenberg, Patrick, Sentilhes, Loïc, Sroussi, Jeremy, Vayssière, Christophe, Verspyck, Eric, Vivanti, Alexandre J., Winer, Norbert, Alessandrini, Vivien, and Schmitz, Thomas

Published
2020
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8. Tranexamic acid for the prevention of blood loss after cesarean among women with twins: a secondary analysis of the TRAnexamic Acid for Preventing Postpartum Hemorrhage Following a Cesarean Delivery randomized clinical trial

Author

Sentilhes, Loïc, Madar, Hugo, Le Lous, Maëla, Sénat, Marie Victoire, Winer, Norbert, Rozenberg, Patrick, Kayem, Gilles, Verspyck, Eric, Fuchs, Florent, Azria, Elie, Gallot, Denis, Korb, Diane, Desbrière, Raoul, Le Ray, Camille, Chauleur, Céline, de Marcillac, Fanny, Perrotin, Franck, Parant, Olivier, Salomon, Laurent J., Gauchotte, Emilie, Bretelle, Florence, Sananès, Nicolas, Bohec, Caroline, Mottet, Nicolas, Legendre, Guillaume, Letouzey, Vincent, Haddad, Bassam, Vardon, Delphine, Mattuizzi, Aurélien, Froeliger, Alizée, Bouchghoul, Hanane, Daniel, Valérie, Regueme, Sophie, Roussillon, Caroline, Georget, Aurore, Darsonval, Astrid, Benard, Antoine, and Deneux-Tharaux, Catherine

Published
2022
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9. Arabin pessary to prevent adverse perinatal outcomes in twin pregnancies with a short cervix: a multicenter randomized controlled trial (PESSARONE)

Author

Groussolles, Marion, Winer, Norbert, Sentilhes, Loïc, Biquart, Florence, Massoud, Mona, Vivanti, Alexandre J., Bouchghoul, Hanane, Rozenberg, Patrick, Olivier, Pascale, Desbriere, Raoul, Chauleur, Celine, Perrotin, Franck, Coatleven, Frederic, Fuchs, Florent, Bretelle, Florence, Tsatsaris, Vassilis, Salomon, Laurent J., Sananes, Nicolas, Kayem, Gilles, Houflin-Debarge, Veronique, Schmitz, Thomas, Benoist, Guillaume, Arnaud, Catherine, Ehlinger, Virginie, and Vayssière, Christophe

Published
2022
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10. Oxytocin versus prostaglandins for labour Induction of women with an unfavourable cervix after 24 hours of cervical ripening (OPIC): protocol for an open multicentre randomised non-inferiority trial

Author

De Berti, Marion, primary, Le Gouge, Amélie, additional, Monmousseau, Fanny, additional, Gallot, Denis, additional, Sentilhes, Loïc, additional, Winer, Norbert, additional, Legendre, Guillaume, additional, Desbriere, Raoul, additional, Girault, Aude, additional, Pozzi, Jordan, additional, Gachon, Bertrand, additional, Barjat, Thiphaine, additional, Perrotin, Franck, additional, Brunet-Houdard, Solène, additional, and Diguisto, Caroline, additional

Published
2023
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12. Reducing neonatal morbidity by discontinuing oxytocin during the active phase: the STOPOXY trial

Author

Girault, Aude, primary, Sentilhes, Loïc, additional, Desbriere, Raoul, additional, Rozenberg, Patrick, additional, Korb, Diane, additional, Bertholdt, Charline, additional, Carrara, Julie, additional, Winer, Norbert, additional, Verspyck, Eric, additional, Boudier, Eric, additional, Barjat, Tiphaine, additional, Levy, Gilles, additional, Roth, Georges Emmanuel, additional, Kayem, Gilles, additional, Massoud, Mona, additional, Bohec, Caroline, additional, Guerby, Paul, additional, Azria, Elie, additional, Blanc, Julie, additional, Heckenroth, Helene, additional, Garabedian, Charles, additional, and Le Ray, Camille, additional

Published
2023
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13. Effectiveness and Costs of Molecular Screening and Treatment for Bacterial Vaginosis to Prevent Preterm Birth: The AuTop Randomized Clinical Trial.

Author

Bretelle, Florence, Loubière, Sandrine, Desbriere, Raoul, Loundou, Anderson, Blanc, Julie, Heckenroth, Hélène, Schmitz, Thomas, Benachi, Alexandra, Haddad, Bassam, Mauviel, Franck, Danoy, Xavier, Mares, Pierre, Chenni, Nawal, Ménard, Jean-Pierre, Cocallemen, Jean-François, Slim, Nadia, Sénat, Marie Victoire, Chauleur, Céline, Bohec, Caroline, and Kayem, Gilles

Published
2024
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14. Cervical ripening in prolonged pregnancies by silicone double balloon catheter versus vaginal dinoprostone slow release system: The MAGPOP randomised controlled trial

Author

Diguisto, Caroline, Le Gouge, Amélie, Arthuis, Chloé, Winer, Norbert, Parant, Olivier, Poncelet, Christophe, Chauleur, Celine, Hannigsberg, Jacob, Ducarme, Guillaume, Gallot, Denis, Gabriel, Rene, Desbriere, Raoul, Beucher, Gael, Faraguet, Cyrille, Isly, Helene, Rozenberg, Patrick, Giraudeau, Bruno, and Perrotin, Franck

Subjects
Balloon dilatation -- Usage -- Comparative analysis, Pregnancy, Protracted -- Care and treatment, Dinoprostone -- Dosage and administration -- Comparative analysis, Labor, Induced (Obstetrics) -- Methods, Biological sciences
Abstract

Background Prolonged pregnancies are a frequent indication for induction of labour. When the cervix is unfavourable, cervical ripening before oxytocin administration is recommended to increase the likelihood of vaginal delivery, but no particular method is currently recommended for cervical ripening of prolonged pregnancies. This trial evaluates whether the use of mechanical cervical ripening with a silicone double balloon catheter for induction of labour in prolonged pregnancies reduces the cesarean section rate for nonreassuring fetal status compared with pharmacological cervical ripening by a vaginal pessary for the slow release of dinoprostone (prostaglandin E2). Methods and findings This is a multicentre, superiority, open-label, parallel-group, randomised controlled trial conducted in 15 French maternity units. Women with singleton pregnancies, a vertex presentation, [greater than or equal to]41+0 and [less than or equal to]42+0 weeks' gestation, a Bishop score Conclusions In this study, we observed no difference in the rates of cesarean deliveries for nonreassuring fetal status between mechanical ripening with a silicone double balloon catheter and pharmacological cervical ripening with a pessary for the slow release of dinoprostone. Trial registration ClinicalTrials.gov NCT02907060., Author(s): Caroline Diguisto 1,2,3,*, Amélie Le Gouge 4, Chloé Arthuis 5, Norbert Winer 5, Olivier Parant 6, Christophe Poncelet 7,8, Celine Chauleur 9,10, Jacob Hannigsberg 11, Guillaume Ducarme 12, Denis [...]

Published
2021
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15. Effectiveness and Costs of Molecular Screening and Treatment for Bacterial Vaginosis to Prevent Preterm Birth: The AuTop Randomized Clinical Trial.

Author

Bretelle, Florence, Loubière, Sandrine, Desbriere, Raoul, Loundou, Anderson, Blanc, Julie, Heckenroth, Hélène, Schmitz, Thomas, Benachi, Alexandra, Haddad, Bassam, Mauviel, Franck, Danoy, Xavier, Mares, Pierre, Chenni, Nawal, Ménard, Jean-Pierre, Cocallemen, Jean-François, Slim, Nadia, Sénat, Marie Victoire, Chauleur, Céline, Bohec, Caroline, and Kayem, Gilles

Published
2023
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16. Effect of Glyburide vs Subcutaneous Insulin on Perinatal Complications Among Women With Gestational Diabetes: A Randomized Clinical Trial

Author

Sénat, Marie-Victoire, Affres, Helene, Letourneau, Alexandra, Coustols-Valat, Magali, Cazaubiel, Marie, Legardeur, Helene, Jacquier, Julie Fort, Bourcigaux, Nathalie, Simon, Emmanuel, Rod, Anne, Héron, Isabelle, Castera, Virginie, Sentilhes, Loic, Bretelle, Florence, Rolland, Catherine, Morin, Mathieu, Deruelle, Philippe, De Carne, Celine, Maillot, François, Beucher, Gael, Verspyck, Eric, Desbriere, Raoul, Laboureau, Sandrine, Mitanchez, Delphine, and Bouyer, Jean

Published
2018
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17. Grandmaternal cells in cord blood

Author

Karlmark, Karlin R., Haddad, Marina El, Donato, Xavier-Côme, Martin, Gabriel V., Bretelle, Florence, Lesavre, Nathalie, Cocallemen, Jean-François, Martin, Marielle, Picard, Christophe, Albentosa, Tiffany, Roudier, Jean, Desbriere, Raoul, and Lambert, Nathalie C.

Subjects
Adult, Medicine (General), HLA compatibility, Cord blood, Aneuploidy, Fetal Blood, Chimerism, Healthy Volunteers, Pedigree, Grandparents, three generations, R5-920, HLA Antigens, Pregnancy, Humans, Medicine, Female, France, Maternal Inheritance, grandmaternal microchimerism, Maternal-Fetal Exchange, Research Paper, Maternal Age
Abstract

s: Background: During pregnancy a feto-maternal exchange of cells through the placenta conducts to maternal microchimerism (Mc) in the child and fetal Mc in the mother. Because of this bidirectional traffic of cells, pregnant women have also acquired maternal cells in utero from their mother and could transfer grandmaternal (GdM) cells to their child through the maternal bloodstream during pregnancy. Thus, cord blood (CB) samples could theoretically carry GdMMc. Nevertheless this has never been demonstrated. Methods: Using Human Leukocyte Antigen (HLA)-specific quantitative PCR assays on three-generation families, we were able to test 28 CB samples from healthy primigravid women for GdMMc in whole blood (WB) and isolated cells (PBMC, T, B, granulocytes, stem cells). Findings: Five CB samples (18%) had GdMMc which could not be confounded with maternal source, with quantities 100 fold lower than maternal Mc in WB and PBMC. Risk of aneuploidies and/or related invasive prenatal procedures significantly correlated with the presence of GdMMc in CB (p=0.024). Significantly decreased HLA compatibility was observed in three-generation families from CB samples carrying GdMMc (p=0.019). Interpretation: Transgenerational transfer of cells could have implications in immunology and evolution. Further analyses will be necessary to evaluate whether GdMMc in CB is a passive or immunologically active transfer and whether invasive prenatal procedures could trigger GdMMc. Funding: Provence-Alpes-Côte d'Azur APEX grant # 2012_06549E, 2012_11786F and 2014_03978) and the Foundation for Medical Research (FRM Grant #ING20140129045).

Published
2021

18. Corrigendum: Factors Predicting the Presence of Maternal Cells in Cord Blood and Associated Changes in Immune Cell Composition

Author

Haddad, Marina El, primary, Karlmark, Karlin, additional, Donato, Xavier-Côme, additional, Martin, Gabriel, additional, Bretelle, Florence, additional, Lesavre, Nathalie, additional, Cocallemen, Jean-François, additional, Martin, Marielle, additional, Picard, Christophe, additional, Roudier, Jean, additional, Desbriere, Raoul, additional, and Lambert, Nathalie C., additional

Published
2021
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20. Factors Predicting the Presence of Maternal Cells in Cord Blood and Associated Changes in Immune Cell Composition

Author

Haddad, Marina El, primary, Karlmark, Karlin R., additional, Donato, Xavier-Côme, additional, Martin, Gabriel V., additional, Bretelle, Florence, additional, Lesavre, Nathalie, additional, Cocallemen, Jean-François, additional, Martin, Marielle, additional, Picard, Christophe, additional, Roudier, Jean, additional, Desbriere, Raoul, additional, and Lambert, Nathalie C., additional

Published
2021
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22. Renin receptor expression in human adipose tissue

Author

Achard, Vincent, Boullu-Ciocca, Sandrine, Desbriere, Raoul, Nguyen, Genevieve, and Grino, Michel

Subjects
Adipose tissues -- Physiological aspects, Immunohistochemistry -- Research, Polymerase chain reaction -- Analysis, Biological sciences
Abstract

Adipose tissue synthesizes all components of the renin-angiotensin system. The renin receptor (RenR) is able, on renin binding, to increase its efficiency to generate angiotensin I from angiotensinogen. We demonstrate that RenR is specifically synthesized in the stromal portion of human adipose tissue in both isolated interadipocyte stromal cells and in stromal areas. RenR is expressed at the periphery of cells, strongly suggesting a membranal localization. RenR protein expression in primary cultures of human stromal cells decreased significantly during differentiation, whereas RenR mRNA levels did not change, demonstrating that RenR was expressed in both preadipocyte and nonpreadipocyte cells, and was regulated at a posttranscriptional level. Double-labeling immunohistochemistry of human adipose tissue sections revealed that RenR was colocalized with renin, whereas incubation of 3T3-L1, a preadipocyte cell line, with renin stimulated the phosphorylation state of the intracellular signaling pathway ERK 1/2, and short exposure of human adipose stromal cells in primary culture to renin was followed by a long-lasting dose-dependent increase of angiotensin I generation, indicating that adipose RenR is functional. We show, using a large set of human adipose tissue biopsies, that RenR expression was increased in visceral compared with subcutaneous adipose tissue of lean and obese patients. Taken together with our finding that RenR was colocalized with plasminogen activator inhibitor type 1, the main inhibitor of the fibrinolytic system in visceral adipose tissue, the above-mentioned data suggest that RenR plays a role in obesity-induced visceral adipose tissue accumulation and its accompanying cardiovascular complications. immunohistochemistry; adipocyte differentiation; reverse transcriptase-polymerase chain reaction

Published
2007

24. Tranexamic acid for the prevention of postpartum hemorrhage after vaginal delivery: the TRAAP trial

Author

Sentilhes, Loïc, Winer, Norbert, Azria, Elie, Senat, Marie-Victoire, Le Ray, Camille, Vardon, Delphine, Perrotin, Franck, Desbriere, Raoul, Fuchs, Florent, Kayem, Gilles, Ducarme, Guillaume, Doret-Dion, Muriel, Huissoud, Cyril, Bohec, Caroline, Deruelle, Philippe, Darsonval, Astrid, Chretien, Jean-Marie, Seco, Aurélien, Daniel, Valérie, Deneux-Tharaux, Catherine, Groupe de Recherche en Obstétrique et Gynécologie (GROG), ., CHU Bordeaux [Bordeaux], Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Physiopathologie des Adaptations Nutritionnelles (PhAN), Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN), Institut des Maladies de l'Appareil Digestif, Université de Nantes (UN), Centre de Recherche en Nutrition Humaine, Centre hospitalier universitaire de Nantes (CHU Nantes), Université Paris Descartes - Paris 5 (UPD5), Service de biostatistique et information médicale de l’hôpital Saint Louis (Equipe ECSTRA) (SBIM), Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut national du cancer [Boulogne] (INCA)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Sorbonne Paris Cité (COMUE) (USPC), AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Centre Hospitalier Régional Universitaire de Tours (CHRU de Tours), Hôpital Saint Joseph, Centre Hospitalier Universitaire de Montpellier (CHU Montpellier ), Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Obstetrics and Gynecology, Hôpital de l'Hôtel-Dieu, Assistance Publique - Hôpitaux de Paris (AP-HP), Centre Hospitalier Départemental Vendée, Hospices Civils de Lyon (HCL), Hôpital de la Croix-Rousse [CHU - HCL], Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Hôpital Jeanne de Flandre [Lille], Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Collège National des Gynécologues et Obstétriciens Français (CNGOF), and Society for Maternal-Fetal Medicine. USA.

Subjects
[SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

25. Glyburide versus insulin for the prevention of perinatal complications of Gestational Diabetes Mellitus: a pragmatic, non-inferiority, randomized trial

Author

Deruelle, Philippe, Letourneau, Alexandra, Vayssiere, Christophe, Legardeur, Helene, Rozenberg, Patrick, Girard, Guillaume, Simon, Emmanuel, Beucher, Gael, Verspyck, Eric, Desbriere, Raoul, Sentilhes, Loic, Bretelle, Florence, Bouyer, Jean, Senat, Marie-Victoire, Service de Gynécologie - Obstétrique [Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CHU Toulouse [Toulouse], Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Risques cliniques et sécurité en santé des femmes et en santé périnatale (RISCQ), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Department of obstetrics and gynecology, CHI Poissy-Saint-Germain, Service de Chirurgie Orthopédique et Traumatologique [CHU Clermont-Ferrand], CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Service de Gynécologie-Obstétrique et Médecine de la Reproduction [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Service de gynécologie et obstétrique [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Service d'Obstétrique et Gynécologique [Angers], Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Gynépole, Aix Marseille Université (AMU)- Hôpital Nord [CHU - APHM], Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Service de Gynécologie Obstétrique [AP-HP Hôpital Bicêtre], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, Université Paris-Sud - Paris 11 - Faculté de médecine (UP11 UFR Médecine), Université Paris-Sud - Paris 11 (UP11), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), and Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics
Abstract

38th Annual Meeting and Pregnancy Meeting of the Society-for-Maternal-Fetal-Medicine, Dallas, TX, JAN 29-FEB 03, 2018; International audience

Published
2018

28. Reducing neonatal morbidity by discontinuing oxytocin during the active phase of first stage of labor: a multicenter randomized controlled trial STOPOXY.

Author

Girault, Aude, Goffinet, François, Le Ray, Camille, on behalf of the collaborators of the STOPOXY trial and the Groupe de Recherche en Obstétrique et Gynécologie (GROG), Azria, Elie, Barjat, Tiphaine, Bertholdt, Charline, Blanc, Julie, Bohec, Caroline, Boudier, Eric, Carrara, Julie, Desbriere, Raoul, Doret, Muriel, Garabedian, Charles, Heckenroth, Hélène, Kayem, Gilles, Korb, Diane, Levy, Gilles, Roth, Georges-Emmanuel, and Rozenberg, Patrick

Subjects
RANDOMIZED controlled trials, NEONATAL mortality, RETROSPECTIVE studies, CROSS-sectional method, ULTRASONIC imaging, FIRST stage of labor (Obstetrics)
Abstract

Background: Oxytocin is effective in reducing labor duration, but can be associated with fetal and maternal complications such as neonatal acidosis and post-partum hemorrhage. When comparing discontinuing oxytocin in the active phase with continuing oxytocin infusion, previous studies were underpowered to show a reduction in neonatal morbidity. Thus, we aim at evaluating the impact of discontinuing oxytocin during the active phase of the first stage of labor on the neonatal morbidity rate.Methods: STOPOXY is a multicenter, randomized, open-label, controlled trial conducted in 20 maternity units in France. The first participant was recruited January 17th 2020. The trial includes women with a live term (≥37 weeks) singleton, in cephalic presentation, receiving oxytocin before 4 cm, after an induced or spontaneous labor. Women aged < 18 years, with a lack of social security coverage, a scarred uterus, a multiple pregnancy, a fetal congenital malformation, a growth retardation <3rd percentile or an abnormal fetal heart rate at randomization are excluded. Women are randomized before 6 cm when oxytocin is either continued or discontinued. Randomization is stratified by center and parity. The primary outcome, neonatal morbidity is assessed using a composite variable defined by an umbilical arterial pH at birth < 7.10 and/or a base excess > 10 mmol/L and/or umbilical arterial lactates> 7 mmol/L and/or a 5 min Apgar score < 7 and/or admission in neonatal intensive care unit. The primary outcome will be compared between the two groups using a chi-square test with a p-value of 0.05. Secondary outcomes include neonatal complications, duration of active phase, mode of delivery, fetal and maternal complications during labor and delivery, including cesarean delivery rate and postpartum hemorrhage, and birth experience. We aim at including 2475 women based on a reduction in neonatal morbidity from 8% in the control group to 5% in the experimental group, with a power of 80% and an alpha risk of 5%.Discussion: Discontinuing oxytocin during the active phase of labor could improve both child health, by reducing moderate to severe neonatal morbidity, and maternal health by reducing cesarean delivery and postpartum hemorrhage rates.Trial Registration: Clinical trials NCT03991091 , registered June 19th, 2019. [ABSTRACT FROM AUTHOR]

Published
2020
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29. Are men ready to use thermal male contraception? Acceptability in two French populations: New fathers and new providers

Author

Amouroux, Marie, Mieusset, Roger, Desbriere, Raoul, Opinel, Pierre, Karsenty, Gilles, Paci, Marine, Fernandes, Sara, Courbiere, Blandine, Perrin, Jeanne, Département Universitaire de Médecine Générale, Faculté de Médecine de Marseille , Aix Marseille Université AMU, Centre de stérilité masculine, Service d'urologie-andrologie, Hôpital Paule de Viguier, CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse], Service de Gynécologie-Obstétrique, Pôle Parents Enfants,Hôpital Saint-Joseph, Centre Hospitalier du Pays d'Aix, Chirurgie urologique et transplantation rénale [Hôpital de la Conception - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Centre Clinico-Biologique d’Assistance Médicale à la Procréation - CECOS [Hôpital de la Conception - APHM], Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Marseille medical genetics - Centre de génétique médicale de Marseille (MMG), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Santé Publique, Aix Marseille Université (AMU), Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE), Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UMR237-Aix Marseille Université (AMU)-Avignon Université (AU), ANR-11-IDEX-0001,Amidex,INITIATIVE D'EXCELLENCE AIX MARSEILLE UNIVERSITE(2011), Aix-Marseille Université - École de médecine (AMU SMPM MED), Aix-Marseille Université - Faculté des sciences médicales et paramédicales (AMU SMPM), Aix Marseille Université (AMU)-Aix Marseille Université (AMU), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), and Avignon Université (AU)-Aix Marseille Université (AMU)-Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique (CNRS)

Subjects
Male, MESH: Body Temperature, Medical Doctors, Physiology, Health Care Providers, Maternal Health, lcsh:Medicine, Choice Behavior, Body Temperature, Fathers, Families, Pregnancy, MESH: Contraception/psychology, Medicine and Health Sciences, Medical Personnel, Reproductive System Procedures, lcsh:Science, Contraception Behavior, MESH: Contraception/methods, MESH: Middle Aged, Obstetrics and Gynecology, Middle Aged, Professions, Contraception, Physiological Parameters, MESH: Young Adult, Female, Research Article, Adult, MESH: Attitude, Parenting Behavior, Surgical and Invasive Medical Procedures, MESH: Choice Behavior, [SDV.BDLR.RS]Life Sciences [q-bio]/Reproductive Biology/Sexual reproduction, Young Adult, MESH: Fathers/psychology, MESH: Cross-Sectional Studies, Physicians, Vasectomy, Humans, Female Contraception, MESH: Contraception Behavior, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, Behavior, MESH: Humans, Surgical Excision, lcsh:R, Biology and Life Sciences, MESH: Adult, [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology, MESH: Male, Male Contraception, Health Care, Cross-Sectional Studies, Attitude, People and Places, Women's Health, lcsh:Q, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Population Groupings, MESH: Female
Abstract

International audience; BACKGROUND:Since the 1970s, international research has actively pursued hormonal male contraception (HMC) and, to a lesser extent, thermal male contraception (TMC). Although the efficacy of TMC has been confirmed in limited populations, its acceptability has not been studied in either potential users or potential prescribers.METHODS:A cross-sectional descriptive multicentre study of potential male users of TMC (new fathers) and potential prescribers of TMC (new providers) was conducted between November 2016 and February 2017.The participants completed a 3-part survey, and their responses were evaluated to i) determine their socio-demographic profiles; ii) identify personal experiences with contraception; and iii) gauge the participants' knowledge, interest and preference for male contraception, particularly TMC. For new providers only, the survey included a fourth part to evaluate professional experience with male contraception.RESULTS:The participation rate was 51% for new fathers (305 NFs) and 34% for new providers (300 NPs, including 97 men (male new providers, MNPs) and 203 women (female new providers, FNPs)). Only 3% of NFs and 15% of NPs knew about TMC (including 26% of the MNPs and 10% of the FNPs, p

Published
2017

30. 485 Efficacy of early versus late intrauterine balloon tamponade in the management of severe postpartum hemorrhage

Author

Rozenberg, Patrick, Sentilhes, Loïc, Winer, Norbert, goffinet, Francois, Vayssiere, Christophe, senat, Marie-Victoire, Morel, Olivier, Haddad, Bassam, Garabédian, Charles, Vivanti, Alexandre, Perrotin, Franck, Kayem, Gilles, Raynal, Pierre, Blanc, Julie, Verspyck, Eric, Gallot, Denis, Sananes, Nicolas, séco, Aurélien, Desbrière, Raoul, and Deneux-Tharaux, Catherine

Published
2021
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31. 1 Tranexamic acid for the prevention of postpartum hemorrhage after cesarean delivery: the TRAAP2 trial

Author

Sentilhes, Loïc, Marie-Victoire senat, Le Lous, Maëla, Winer, Norbert, Rozenberg, Patrick, Kayem, Gilles, Verspyck, Eric, Fuchs, Florent, AZRIA, Elie, Gallot, Denis, Korb, Diane, Desbriere, Raoul, Le Ray, Camille, Chauleur, Céline, De Marcillac, Fanny, Perrotin, Franck, Parant, Olivier, Salomon, Laurent, Gauchotte, Emilie, Bretelle, Florence, Benard, Antoine, Georget, Aurore, Darsonval, Astrid, and Deneux-Tharaux, Catherine

Published
2021
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35. 988: Glyburide versus insulin for the prevention of perinatal complications of Gestational Diabetes Mellitus: a pragmatic, non-inferiority, randomized trial

Author

Deruelle, Philippe, primary, Letourneau, Alexandra, additional, Vayssière, Christophe, additional, Legardeur, Helene, additional, Rozenberg, Patrick, additional, Girard, Guillaume, additional, Simon, Emmanuel, additional, Beucher, Gael, additional, Verspyck, Eric, additional, Desbriere, Raoul, additional, Sentilhes, Loic, additional, Bretelle, Florence, additional, Bouyer, Jean, additional, and Senat, Marie-Victoire, additional

Published
2018
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37. Managing pain and anxiety during transabdominal chorionic villus sampling. A noninferiority randomized trial of nitrous oxide vs local anesthesia.

Author

Katsogiannou, Maria, Donato, Xavier‐Côme, Loundou, Anderson, Glowaczower, Eric, Raffray, Marie, Planchet‐Barraud, Brigitte, Quarello, Edwin, Brechard, Marie‐Pierre, Desbriere, Raoul, Donato, Xavier-Côme, Planchet-Barraud, Brigitte, and Brechard, Marie-Pierre

Subjects
CHORIONIC villus sampling, LOCAL anesthesia, FALSE positive error, PAIN management, VISUAL analog scale, NITROUS oxide
Abstract

Introduction: Transabdominal chorionic villus sampling (CVS) is an invasive procedure for prenatal diagnosis reported to be associated with anxiety and pain. In this context, the need for analgesia during CVS has been considered useful. Even though several authors have been interested in pain management during amniocentesis, no study has been published on pain reduction during CVS. Our objective was to evaluate pain and anxiety management during transabdominal CVS using nitrous oxide (N2 O) and local anesthesia.Material and Methods: In a randomized controlled noninferiority trial, self-administered nitrous oxide (N2 O) inhalation (equimolar premix of oxygen and nitrous oxide) was compared with local anesthesia (1% lidocaine) before CVS. Primary outcome was pain and secondary outcome was anxiety, both measured on a visual analog scale 30-60 minutes before, immediately after (5-10 minutes) and 30-60 minutes after CVS. With a statistical power of 90%, type I error of 5% and two-sided test and potential exclusions, a sample size of 96 patients per group was enrolled and randomized. No patient was enrolled before the trial registration date.Results: From 13 March 2013 through 10 February 2015, 192 patients (96 per group) were screened and randomized. Most characteristics were similar across groups. Pain in the N2 O group was 2.65 ± 0.22 vs 3.32 ± 0.26 in local anesthesia group [mean ± standard error of mean  (SEM)]. Mean anxiety in the N2 O group was 3.17 ± 0.27 vs 5.19 ± 0.30 in the local anesthesia group.Conclusion: N2 O was as efficient and even superior to local anesthesia for both pain and anxiety reduction during CVS, as the 95% confidence intervals were both below the prespecified noninferiority margin of 0.8 and below zero. [ABSTRACT FROM AUTHOR]

Published
2019
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39. 1: Tranexamic acid for the prevention of postpartum hemorrhage after vaginal delivery: the TRAAP trial

Author

Sentilhes, Loïc, Winer, Norbert, Azria, Elie, Sénat, Marie-Victoire, Le Ray, Camille, Vardon, Delphine, Perrotin, Franck, Desbrière, Raoul, Fuchs, Florent, Kayem, Gilles, Ducarme, Guillaume, Doret-Dion, Muriel, Huissoud, Cyril, Bohec, Caroline, Deruelle, Philippe, Darsonval, Astrid, Chrétien, Jean-Marie, Séco, Aurélien, Daniel, Valérie, and Deneux-Tharaux, Catherine

Published
2018
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40. Leptotrichia amnionii and the female reproductive tract

Author

Gundi, Vijay A.K.B., Desbriere, Raoul, and La Scola, Bernard

Abstract

To the Editor: Detection of new bacteria, human complex microflora, by using 16S rRNA gene amplification and sequencing has been reported (1). 16S rRNA gene amplification and sequencing detected pyosalpinx, [...]

Published
2004

43. Reply of the authors

Author

Carcopino, Xavier, primary, Blanc, Julie, additional, Courbiere, Blandine, additional, Desbriere, Raoul, additional, Bretelle, Florence, additional, Boubli, Léon, additional, and d’Ercole, Claude, additional

Published
2011
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