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6 results on '"Desaldeleer C"'

4. Chronic hepatitis associated with antiribosomal-P autoantibodies in a 14-year-old girl.

Author

Mejean C, Bertin D, Guetta K, Desaldeleer C, Butori M, Roquelaure B, and Fabre A

Abstract

We reported the first pediatric case of auto-immune hepatitis with positive anti-P antibodies. On the basis of our findings, adding auto anti-P screening in pediatric seronegative HAI may be recommended., Competing Interests: None declared., (© 2019 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.)

Published
2019
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5. Maternal 18:3n-3 favors piglet intestinal passage of LPS and promotes intestinal anti-inflammatory response to this bacterial ligand.

Author

Desaldeleer C, Ferret-Bernard S, de Quelen F, Le Normand L, Perrier C, Savary G, Romé V, Michel C, Mourot J, Le Huërou-Luron I, and Boudry G

Subjects
Animals, Animals, Newborn, Cells, Cultured, Cytokines metabolism, DNA, Bacterial genetics, Diet veterinary, Fatty Acids, Omega-6 pharmacology, Female, Inflammation pathology, Jejunum immunology, Jejunum microbiology, Maternal Nutritional Physiological Phenomena, Mesenteric Veins drug effects, Mesenteric Veins metabolism, Microbiota, Permeability, Pregnancy, Pregnancy Outcome, Swine, Weaning, Fatty Acids, Omega-3 pharmacology, Jejunum drug effects, Lipopolysaccharides adverse effects
Abstract

We recently observed that maternal 18:3n-3 increases piglet jejunal permeability. We hypothesized that this would favor intestinal lipopolysaccharide (LPS) passage and alter gut immune system education toward this bacterial ligand. Sows were fed 18:3n-3 or 18:2n-6 diets throughout gestation and lactation. In each litter, two piglets were given oral Gram-negative spectrum antibiotic from post-natal day (PND) 14 to 28. All piglets were weaned on a regular diet at PND28. 18:3n-3 piglets exhibited greater jejunal permeability to FITC-LPS at PND28. Levels of 18:3n-3 but neither 20:5n-3 nor 20:4n-6 were greater in mesenteric lymph nodes (MLN) of 18:3n-3 piglets. Jejunal explant or MLN cell cytokine responses to LPS were not influenced by the maternal diet. Antibiotic increased jejunal permeability to FITC-LPS and lowered the level of 20:5n-3 in MLN, irrespective of the maternal diet. At PND52, no long-lasting effect of the maternal diet or antibiotic treatment on jejunal permeability was noticed. 18:3n-3 and 20:4n-6 levels were greater and lower, respectively, in MLN of 18:3n-3 compared to 18:2n-6 piglets. IL-10 production by MLN cells in response to LPS was greater in the 18:3n-3 group, irrespective of the neonatal antibiotic treatment. IL-8 secretion by jejunal explants in response to LPS was lower in antibiotic-treated 18:3n-3 compared to 18:2n-6 piglets. Finally, proportion of MHC class II(+) antigen-presenting cells was greater in 18:3n-3 than 18:2n-6 MLN cells. In conclusion, maternal 18:3n-3 directs the intestinal immune response to LPS toward an anti-inflammatory profile beyond the breastfeeding period; microbiota involvement seems dependent of the immune cells considered., (Copyright © 2014 Elsevier Inc. All rights reserved.)

Published
2014
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6. Chylomicron retention disease.

Author

Desaldeleer C, Henno S, Bruneau B, and Dabadie A

Subjects
Humans, Hypobetalipoproteinemias genetics, Hypobetalipoproteinemias pathology, Infant, Malabsorption Syndromes genetics, Malabsorption Syndromes pathology, Male, Mutation, Duodenum pathology, Hypobetalipoproteinemias diagnosis, Malabsorption Syndromes diagnosis, Monomeric GTP-Binding Proteins genetics
Published
2013
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