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22 results on '"Desai, Sheena"'

6. The Impact of COVID-19 on Dermatology Clinical Trials

Author

Desai, Sheena, Manjaly, Priya, Lee, Karen J., Li, Sara J., Manjaly, Cyriac, and Mostaghimi, Arash

Subjects
medicine.medical_specialty, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), SARS-CoV-2, business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), MEDLINE, COVID-19, Cell Biology, Dermatology, Biochemistry, Article, Clinical trial, Pandemic, medicine, Humans, Intensive care medicine, business, Pandemics, Personal Protective Equipment, Molecular Biology
Abstract

The coronavirus disease 2019 (COVID-19) pandemic is a grave public health crisis, causing massive disruption to daily life. Dermatology clinical trials in psoriasis, atopic dermatitis, and hidradenitis have been suspended, terminated, or otherwise disrupted. Clinical investigators need to embrace a COVID-19 new normal and adjust research procedures to mitigate the risk of transmitting severe acute respiratory syndrome coronavirus 2 and depleting personal protective equipment while maintaining scientific rigor.

Published
2021

7. Clinical Characteristics, Disease Course, and Outcomes of Patients With Acute Generalized Exanthematous Pustulosis in the US

Author

Creadore, Andrew, primary, Desai, Sheena, additional, Alloo, Allireza, additional, Dewan, Anna K., additional, Bakhtiar, Mina, additional, Cruz-Diaz, Carla, additional, Femia, Alisa, additional, Fox, Lindy, additional, Katz, Kimberly L., additional, Micheletti, Robert, additional, Nelson, Caroline A., additional, Ortega-Loayza, Alex G., additional, Patrinely, J. Randall, additional, Plovanich, Molly, additional, Rosenbach, Misha, additional, Shaigany, Sheila, additional, Shields, Bridget E., additional, Saleh, Jamal Z., additional, Sharif-Sidi, Zakariyah, additional, Shinkai, Kanade, additional, Smith, Jacob, additional, Su, Chang, additional, Wanat, Karolyn A., additional, Wieser, Jill K., additional, Wright, Shari, additional, Noe, Megan H., additional, and Mostaghimi, Arash, additional

Published
2022
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12. Evaluation of a Case Series of Patients With Palmoplantar Pustulosis in the United States

Author

Noe, Megan H., Wan, Marilyn T., Mostaghimi, Arash, Gelfand, Joel M., Agnihothri, Ritesh, Armstrong, April W., Bhutani, Tina, Bridges, Alina, Brownstone, Nicholas, Butt, Melissa, Duffin, Kristina P. Callis, Carr, Christian, Creadore, Andrew, DeNiro, Katherine L., Desai, Sheena, Dominguez, Arturo R., Duffy, Emily K., Fairley, Janet A., Femia, Alisa, Gudjonsson, Johann E., Kaffenberger, Jessica A., Katz, Kimberly L., Kirby, Joslyn S., Le, Stephanie T., Martinez, Edgar, Maverakis, Emanual, Myers, Bridget, Naik, Haley B., Nelson, Caroline A., Ortega-Loayza, Alex G., Plovanich, Molly E., Rangel, Lauren K., Ravi, Vignesh, Reddy, Vidhatha D., Saleh, Jamal Z., Sandhu, Jeena K., Shakshouk, Hadir, Shields, Bridget E., Sharif-Sidi, Zakariyah, Smith, Jacob, Steahr, Amanda, Toussi, Atrin, Wanat, Karolyn A., Wang, Bo, Wei, Brian M., Weinhammer, Annika, Worswick, Scott D., and Yang, Alexander

Subjects
Skin Diseases, Vesiculobullous, Brief Report, Humans, Psoriasis, Dermatology, Exanthema
Abstract

IMPORTANCE: Palmoplantar pustulosis (PPP) is a is a chronic, orphan disease with limited epidemiological data. OBJECTIVE: To describe the clinical characteristics, treatments, longitudinal disease course, and health care utilization in adults with PPP across the US. DESIGN, SETTING, AND PARTICIPANTS: This retrospective, longitudinal case series from 20 academic dermatology practices in the US included a consecutive sample of 197 adults who met the European Rare and Severe Psoriasis Expert Network consensus definition for PPP between January 1, 2007, and December 31, 2018. Data analysis was performed June 2020 to December 2020. MAIN OUTCOMES AND MEASURES: The primary outcome was to describe the patient characteristics, associated medical comorbidities, treatment patterns, complications, and PPP-specific health care utilization. RESULTS: Of 197 patients, 145 (73.6%) were female, and the mean (SD) age at presentation was 53.0 (12.6) years, with a mean (SD) follow-up time of 22.1 (28.0) months. On initial presentation, 95 (48.2%) patients reported skin pain, and 39 (19.8%) reported difficulty using hands and/or feet. Seventy patients (35.5%) were treated with systemic treatments, and use of more than 20 different systemic therapies was reported. In patients with at least 6 months of follow-up (n = 128), a median (IQR) of 3.7 (4-10) dermatology visits per year were reported; 24 (18.8%) patients had 5 or more visits during the study period. CONCLUSIONS AND RELEVANCE: In this case series, PPP was associated with persistent symptoms, continued health care utilization, and a lack of consensus regarding effective treatments, emphasizing the unmet medical need in this population. Additional research is necessary to understand treatment response in these patients.

Published
2022

19. Evaluation of a Case Series of Patients With Generalized Pustular Psoriasis in the United States.

Author

Noe, Megan H., Wan, Marilyn T., Mostaghimi, Arash, Gelfand, Joel M., Agnihothri, Ritesh, Armstrong, April W., Bhutani, Tina, Bridges, Alina, Brownstone, Nicholas, Butt, Melissa, Duffin, Kristina P. Callis, Carr, Christian, Creadore, Andrew, DeNiro, Katherine L., Desai, Sheena, Dominguez, Arturo R., Duffy, Emily K., Fairley, Janet A., Femia, Alisa, and Gudjonsson, Johann E.

Published
2022
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22. Comparison of Shave and Punch Biopsy Utilization Among Dermatology Practices.

Author

Desai, Sheena, Creadore, Andrew, Duncan, Lyn M., Lian, Christine G., Yasuda, Mariko R., Mostaghimi, Arash, Barbieri, John S., and Hartman, Rebecca I.

Subjects
DERMATOLOGY, SKIN biopsy, REIMBURSEMENT, PATHOLOGY, SUBGROUP analysis (Experimental design)
Abstract

In 2019, the 2 Current Procedural Terminology (CPT) codes for skin biopsies were replaced with 6 new CPT codes to allow for technique specification and differential reimbursement. We sought to evaluate whether the concurrent decrease in reimbursement for shave biopsies and increase in reimbursement for punch biopsies led to utilization changes. We examined shave and punch biopsies submitted for pathologic examination at 3 academic centers in May 2018 and May 2019. We performed ?2 tests to evaluate for changes in the ratio of biopsy utilization over time, with subgroup analyses by practice setting and provider type. Totals included 11,785 (12.11% punch) and 11,291 (12.08% punch) biopsies submitted in May 2018 and May 2019, respectively. Our results demonstrate small yet important changes in biopsy use patterns within the context of recent reimbursement changes when analyzing academic and private practices separately. Although small in magnitude, this change in behavior may have a substantial impact when extrapolated to behavior across the nation. [ABSTRACT FROM AUTHOR]

Published
2021
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