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2. Pregnancy outcomes after first-trimester treatment with artemisinin derivatives versus non-artemisinin antimalarials: a systematic review and individual patient data meta-analysis.

Author

Saito, Makoto, McGready, Rose, Tinto, Halidou, Rouamba, Toussaint, Mosha, Dominic, Rulisa, Stephen, Kariuki, Simon, Desai, Meghna, Manyando, Christine, Njunju, Eric, Sevene, Esperanca, Vala, Anifa, Augusto, Orvalho, Clerk, Christine, Were, Edwin, Mrema, Sigilbert, Kisinza, William, Byamugisha, Josaphat, Kagawa, Mike, Singlovic, Jan, Yore, Mackensie, van Eijk, Anna, Mehta, Ushma, Stergachis, Andy, Hill, Jenny, Stepniewska, Kasia, Gomes, Melba, Guérin, Philippe, Nosten, Francois, Ter Kuile, Feiko, and Dellicour, Stephanie

Subjects
Female, Pregnancy, Humans, Antimalarials, Pregnancy Outcome, Quinine, Pregnancy Trimester, First, Abortion, Spontaneous, Stillbirth, Prospective Studies, Artemether, Artemether, Lumefantrine Drug Combination, Malaria, Falciparum, Malaria, Drug Combinations, Ethanolamines
Abstract

BACKGROUND: Malaria in the first trimester of pregnancy is associated with adverse pregnancy outcomes. Artemisinin-based combination therapies (ACTs) are a highly effective, first-line treatment for uncomplicated Plasmodium falciparum malaria, except in the first trimester of pregnancy, when quinine with clindamycin is recommended due to concerns about the potential embryotoxicity of artemisinins. We compared adverse pregnancy outcomes after artemisinin-based treatment (ABT) versus non-ABTs in the first trimester of pregnancy. METHODS: For this systematic review and individual patient data (IPD) meta-analysis, we searched MEDLINE, Embase, and the Malaria in Pregnancy Library for prospective cohort studies published between Nov 1, 2015, and Dec 21, 2021, containing data on outcomes of pregnancies exposed to ABT and non-ABT in the first trimester. The results of this search were added to those of a previous systematic review that included publications published up until November, 2015. We included pregnancies enrolled before the pregnancy outcome was known. We excluded pregnancies with missing estimated gestational age or exposure information, multiple gestation pregnancies, and if the fetus was confirmed to be unviable before antimalarial treatment. The primary endpoint was adverse pregnancy outcome, defined as a composite of either miscarriage, stillbirth, or major congenital anomalies. A one-stage IPD meta-analysis was done by use of shared-frailty Cox models. This study is registered with PROSPERO, number CRD42015032371. FINDINGS: We identified seven eligible studies that included 12 cohorts. All 12 cohorts contributed IPD, including 34 178 pregnancies, 737 with confirmed first-trimester exposure to ABTs and 1076 with confirmed first-trimester exposure to non-ABTs. Adverse pregnancy outcomes occurred in 42 (5·7%) of 736 ABT-exposed pregnancies compared with 96 (8·9%) of 1074 non-ABT-exposed pregnancies in the first trimester (adjusted hazard ratio [aHR] 0·71, 95% CI 0·49-1·03). Similar results were seen for the individual components of miscarriage (aHR=0·74, 0·47-1·17), stillbirth (aHR=0·71, 0·32-1·57), and major congenital anomalies (aHR=0·60, 0·13-2·87). The risk of adverse pregnancy outcomes was lower with artemether-lumefantrine than with oral quinine in the first trimester of pregnancy (25 [4·8%] of 524 vs 84 [9·2%] of 915; aHR 0·58, 0·36-0·92). INTERPRETATION: We found no evidence of embryotoxicity or teratogenicity based on the risk of miscarriage, stillbirth, or major congenital anomalies associated with ABT during the first trimester of pregnancy. Given that treatment with artemether-lumefantrine was associated with fewer adverse pregnancy outcomes than quinine, and because of the known superior tolerability and antimalarial effectiveness of ACTs, artemether-lumefantrine should be considered the preferred treatment for uncomplicated P falciparum malaria in the first trimester. If artemether-lumefantrine is unavailable, other ACTs (except artesunate-sulfadoxine-pyrimethamine) should be preferred to quinine. Continued active pharmacovigilance is warranted. FUNDING: Medicines for Malaria Venture, WHO, and the Worldwide Antimalarial Resistance Network funded by the Bill & Melinda Gates Foundation.

Published
2023

3. Fetal sex and risk of pregnancy-associated malaria in Plasmodium falciparum-endemic regions: a meta-analysis

Author

Unger, Holger W., Hadiprodjo, Anastasia Jessica, Gutman, Julie R., Briand, Valerie, Fievet, Nadine, Valea, Innocent, Tinto, Halidou, D’Alessandro, Umberto, Landis, Sarah H., Ter Kuile, Feiko, Ouma, Peter, Oneko, Martina, Mwapasa, Victor, Slutsker, Laurence, Terlouw, Dianne J., Kariuki, Simon, Ayisi, John, Nahlen, Bernard, Desai, Meghna, Madanitsa, Mwayi, Kalilani-Phiri, Linda, Ashorn, Per, Maleta, Kenneth, Tshefu-Kitoto, Antoinette, Mueller, Ivo, Stanisic, Danielle, Cates, Jordan, Van Eijk, Anna Maria, Ome-Kaius, Maria, Aitken, Elizabeth H., and Rogerson, Stephen J.

Published
2023
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4. Feasibility, safety, and impact of the RTS,S/AS01E malaria vaccine when implemented through national immunisation programmes: evaluation of cluster-randomised introduction of the vaccine in Ghana, Kenya, and Malawi

Author

Abubakari, Sulemana Watara, Akumani, Albert, Adu-Gyasi, Dennis, Sarfo, Augustine, Odei-Lartey, Elezier, Agbokey, Francis, Amenga-Etego, Seeba, Gyaase, Stephany, Buabeng, Patrick, Awini, Elizabeth, Sylverken, Justice, Kampim, Aaron, Koram, Kwadwo A, Hodgson, Abraham, Binka, Fred Newton, Okine, Rafiq Nii Attoh, Tweneboah, Peter Ofori, Ondiegi, Bella, Seda, Brian, Akach, Dorcas, Orwa, Gordon, Nyang’au, Isabella, Odunga, Oscar, Gumba, Francis, Copeland, Nathanial, Khazenzi, Cynthia, Mumo, Eda, Musa, Monica, Ogero, Morris, English, Mike, Haji, Adam, Njoroge, Josephine, Msuku, Harrison, Samuel, Vincent, Mariko, Hillary Topazian, Juliano, Jon, Msumba, Lusungu, Mungwira, Randy George, Zimba, Boston Edward, Desai, Meghna, Furrer, Eliane, Aponte, John, Alonso, Pedro, Kalu, Akpaka A, Sillah, Jackson Sophianu, Asante, Kwaku Poku, Mathanga, Don P, Milligan, Paul, Akech, Samuel, Oduro, Abraham, Mwapasa, Victor, Moore, Kerryn A, Kwambai, Titus K, Hamel, Mary J, Gyan, Thomas, Westercamp, Nelli, Kapito-Tembo, Atupele, Njuguna, Patricia, Ansong, Daniel, Kariuki, Simon, Mvalo, Tisungane, Snell, Paul, Schellenberg, David, Welega, Paul, Otieno, Lucas, Chimala, Alfred, Afari, Edwin A, Bejon, Philip, Maleta, Kenneth, Agbenyega, Tsiri, Snow, Robert W, Zulu, Madaliso, Chinkhumba, Jobiba, and Samuels, Aaron M

Published
2024
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5. Does acute malnutrition in young children increase the risk of treatment failure following artemisinin-based combination therapy? A WWARN individual patient data meta-analysis

Author

Stepniewska, Kasia, Allan, Richard, Anvikar, Anupkumar R, Anyorigiya, Thomas A, Ashley, Elizabeth A, Bassat, Quique, Baudin, Elisabeth, Bjorkman, Anders, Bonnet, Maryline, Boulton, Caroline, Bousema, Teun, Carn, Gwenaelle, Carrara, Verena I, D'Alessandro, Umberto, Davis, Timothy ME, Denoeud-Ndam, Lise, Desai, Meghna, Djimde, Abdoulaye A, Dorsey, Grant, Etard, Jean-François, Falade, Catherine, Fanello, Caterina, Gaye, Oumar, Gonzalez, Raquel, Grandesso, Francesco, Grivoyannis, Anastasia D, Grais, Rebecca F, Humphreys, Georgina S, Ishengoma, Deus S, Karema, Corine, Kayentao, Kassoum, Kennon, Kalynn, Kremsner, PeterG, Laman, Moses, Laminou, Ibrahim M, Macete, Eusebio, Martensson, Andreas, Mayxay, Mayfong, Menan, Hervé IB, Menéndez, Clara, Moore, Brioni R, Nabasumba, Carolyn, Ndiaye, Jean-Louis, Nhama, Abel, Nosten, Francois, Onyamboko, Marie, Phyo, Aung Pyae, Ramharter, Michael, Rosenthal, Philip J, Schramm, Birgit, Sharma, Yagya D, Sirima, Sodiomon B, Strub-Wourgaft, Nathalie, Sylla, Khadime, Talisuna, Ambrose O, Temu, Emmanuel A, Thwing, Julie I, Tinto, Halidou, Valentini, Giovanni, White, Nicholas J, Yeka, Adoke, Isanaka, Sheila, Barnes, Karen I, and Guerin, Philippe J

Published
2024
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8. Prevalence of and risk factors for microscopic and submicroscopic malaria infections in pregnancy: a systematic review and meta-analysis

Author

van Eijk, Anna Maria, Stepniewska, Kasia, Hill, Jenny, Taylor, Steve M., Rogerson, Stephen J., Cottrell, Gilles, Chico, R. Matthew, Gutman, Julie R., Tinto, Hallidou, Unger, Holger W., Yanow, Stephanie K., Accrombessi, Manfred, Adegnika, Ayola A., Ahmed, Rukhsana, Arango-Flórez, Eliana María, Arevalo-Herrera, Myriam, Arinaitwe, Emmanual, Arnaldo, Paulo, Ashorn, Per, Ashorn, Ulla, Bardaji, Azucena, Betuela, Inoni, Bharti, Praveen K., Bohissou, Francis, Bôtto-Menezes, Camila, Braun, Vera, Briand, Valerie, Briggs, Jessica, Castellanos, María Eugenia, Chandramohan, Daniel, Chaponda, Enesia Banda, Chitnis, Chetan, Cohee, Lauren M., Cot, Michel, d'Alessandro, Umberto, Denoeud-Ndam, Lise, Desai, Meghna, Dicko, Alassane, Ding, Xavier, Dorsey, Grant, Duffy, Patrick E., Elbadry, Maha A., Enosse, Sonia M., Fan, Yue, Fievet, Nadine, Fried, Michal, Genton, Blaise, Gonzalez, Raquel, Greenwood, Brian, Kalilani, Linda, Kattenberg, Johanna H., Kayentao, Kassoum, Khairallah, Carole, King, Christopher L., Kochar, Dhanpat Kumar, Kochar, Swati, Koukouikila-Koussounda, Felix, Landis, Sarah H., Laufer, Miriam K., Leke, Rose F., Macete, Eusebio, Maculuve, Sonia, Madanitsa, Mwayiwawo, Mahamar, Almahamoudou, Maleta, Ken, Malhotra, Indu, Zoleko Manego, Rella, Martinez-Espinosa, Flor Ernestina, Massougbodji, Achille, Mathanga, Don, Menegon, Michela, Menendez, Clara, Mens, Petra, Meremikwu, Martin, Mockenhaupt, Frank P., Mombo-Ngoma, Ghyslain, Mosha, Dominic, Mueller, Ivo, Nahum, Alain, Natureeba, Paul, Ndam, Nicaise, Ntoumi, Francine, Oduwole, Olabisi A., Okech, Bernard A., Ome-Kaius, Maria, Otieno, Kephas, Padilla, Norma, Ramharter, Michal, Rochford, Rosemary, Rosanas-Urgell, Anna, Ruperez, Maria, Sabourin, Katherine R., Sanz, Sergi, Schallig, Henk D., Scott, Susana, Sevene, Esperanca, Severini, Carlo, Tagbor, Harry, Taylor, Diane Wallace, Traore Coulibaly, Maminata, Vasquez, Ana, Walker-Abbey, Annie, Wylie, Blair J., Zannou, Djimon M., Meshnick, Stephen R., ter Kuile, Feiko O., Mayor, Alfredo, Taylor, Steve M, Rogerson, Stephen J, Chico, R Matthew, Gutman, Julie R, Tinto, Halidou, Unger, Holger W, Yanow, Stephanie K, Meshnick, Steven R, and ter Kuile, Feiko O

Published
2023
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13. Temporal trends in molecular markers of drug resistance in Plasmodium falciparum in human blood and profiles of corresponding resistant markers in mosquito oocysts in Asembo, western Kenya

Author

Zhou, Zhiyong, Gimnig, John E., Sergent, Sheila B., Liu, Ying, Abong’o, Bernard, Otieno, Kephas, Chebore, Winnie, Shah, Monica P., Williamson, John, ter Kuile, Feiko O., Hamel, Mary J., Kariuki, Simon, Desai, Meghna, Samuels, Aaron M., Walker, Edward D., and Shi, Ya Ping

Published
2022
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14. Novel application of one-step pooled molecular testing and maximum likelihood approaches to estimate the prevalence of malaria parasitaemia among rapid diagnostic test negative samples in western Kenya

Author

Shah, Monica P., Chebore, Winnie, Lyles, Robert H., Otieno, Kephas, Zhou, Zhiyong, Plucinski, Mateusz, Waller, Lance A., Odongo, Wycliffe, Lindblade, Kim A., Kariuki, Simon, Samuels, Aaron M., Desai, Meghna, Mitchell, Rebecca M., and Shi, Ya Ping

Published
2022
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16. Intermittent screening and treatment with artemisinin-combination therapy versus intermittent preventive treatment with sulphadoxine-pyrimethamine for malaria in pregnancy: a systematic review and individual participant data meta-analysis of randomised clinical trials

Author

Gutman, Julie R, Khairallah, Carole, Stepniewska, Kasia, Tagbor, Harry, Madanitsa, Mwayiwawo, Cairns, Matthew, L'lanziva, Anne Joan, Kalilani, Linda, Otieno, Kephas, Mwapasa, Victor, Meshnick, Steve, Kariuki, Simon, Chandramohan, Daniel, Desai, Meghna, Taylor, Steve M., Greenwood, Brian, and ter Kuile, Feiko O.

Published
2021
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18. Malaria, malnutrition, and birthweight: A meta-analysis using individual participant data.

Author

Cates, Jordan E, Unger, Holger W, Briand, Valerie, Fievet, Nadine, Valea, Innocent, Tinto, Halidou, D'Alessandro, Umberto, Landis, Sarah H, Adu-Afarwuah, Seth, Dewey, Kathryn G, Ter Kuile, Feiko O, Desai, Meghna, Dellicour, Stephanie, Ouma, Peter, Gutman, Julie, Oneko, Martina, Slutsker, Laurence, Terlouw, Dianne J, Kariuki, Simon, Ayisi, John, Madanitsa, Mwayiwawo, Mwapasa, Victor, Ashorn, Per, Maleta, Kenneth, Mueller, Ivo, Stanisic, Danielle, Schmiegelow, Christentze, Lusingu, John PA, van Eijk, Anna Maria, Bauserman, Melissa, Adair, Linda, Cole, Stephen R, Westreich, Daniel, Meshnick, Steven, and Rogerson, Stephen

Subjects
Humans, Malaria, Malnutrition, Prevalence, Pregnancy, Infant, Newborn, Infant, Low Birth Weight, Africa South of the Sahara, Asia, Pacific Islands, Female, General & Internal Medicine, Medical and Health Sciences
Abstract

BackgroundFour studies previously indicated that the effect of malaria infection during pregnancy on the risk of low birthweight (LBW;

Published
2017

19. Maternal Malaria and Malnutrition (M3) initiative, a pooled birth cohort of 13 pregnancy studies in Africa and the Western Pacific.

Author

Unger, Holger W, Cates, Jordan E, Gutman, Julie, Briand, Valerie, Fievet, Nadine, Valea, Innocent, Tinto, Halidou, d'Alessandro, Umberto, Landis, Sarah H, Adu-Afarwuah, Seth, Dewey, Kathryn G, Ter Kuile, Feiko, Dellicour, Stephanie, Ouma, Peter, Slutsker, Laurence, Terlouw, Dianne J, Kariuki, Simon, Ayisi, John, Nahlen, Bernard, Desai, Meghna, Madanitsa, Mwayi, Kalilani-Phiri, Linda, Ashorn, Per, Maleta, Kenneth, Mueller, Ivo, Stanisic, Danielle, Schmiegelow, Christentze, Lusingu, John, Westreich, Daniel, van Eijk, Anna Maria, Meshnick, Steven, and Rogerson, Stephen

Subjects
Humans, Malaria, Pregnancy Complications, Malnutrition, Prenatal Care, Cohort Studies, Nutritional Status, Fetal Development, Gestational Age, Pregnancy, Adult, Infant, Newborn, Africa, Papua New Guinea, Female, Male, Datasets as Topic, malaria, malnutrition, pregnancy, Clinical Sciences, Public Health and Health Services, Other Medical and Health Sciences
Abstract

PurposeThe Maternal Malaria and Malnutrition (M3) initiative has pooled together 13 studies with the hope of improving understanding of malaria-nutrition interactions during pregnancy and to foster collaboration between nutritionists and malariologists.ParticipantsData were pooled on 14 635 singleton, live birth pregnancies from women who had participated in 1 of 13 pregnancy studies. The 13 studies cover 8 countries in Africa and Papua New Guinea in the Western Pacific conducted from 1996 to 2015.Findings to dateData are available at the time of antenatal enrolment of women into their respective parent study and at delivery. The data set comprises essential data such as malaria infection status, anthropometric assessments of maternal nutritional status, presence of anaemia and birth weight, as well as additional variables such gestational age at delivery for a subset of women. Participating studies are described in detail with regard to setting and primary outcome measures, and summarised data are available from each contributing cohort.Future plansThis pooled birth cohort is the largest pregnancy data set to date to permit a more definite evaluation of the impact of plausible interactions between poor nutritional status and malaria infection in pregnant women on fetal growth and gestational length. Given the current comparative lack of large pregnancy cohorts in malaria-endemic settings, compilation of suitable pregnancy cohorts is likely to provide adequate statistical power to assess malaria-nutrition interactions, and could point towards settings where such interactions are most relevant. The M3 cohort may thus help to identify pregnant women at high risk of adverse outcomes who may benefit from tailored intensive antenatal care including nutritional supplements and alternative or intensified malaria prevention regimens, and the settings in which these interventions would be most effective.

Published
2016

23. Multisectoral prioritization of zoonotic diseases in India: A One Health perspective

Author

Tiwari, Simmi, primary, Roy, Indranil, additional, Daptardar, Monal, additional, Singh, Ruchi, additional, Mishra, Anshuman, additional, Kedia, Richa, additional, Manocha, Harmesh, additional, Dwivedi, Mayank, additional, Dwivedi, Amlesh, additional, Shukla, Gaurish, additional, Shewale, Ajit, additional, Nale, Tushar, additional, Mishra, Dipti, additional, Sharma, Ravi Prakash, additional, Garcia, Daniel, additional, Gokhale, Runa Hatti, additional, Desai, Meghna, additional, and Singh, Sujeet, additional

Published
2024
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27. Burden of malaria in pregnancy among adolescent girls compared to adult women in 5 sub-Saharan African countries: A secondary individual participant data meta-analysis of 2 clinical trials

Author

Pons-Duran, Clara, Mombo-Ngoma, Ghyslain, Macete, Eusebio, Desai, Meghna, Kakolwa, Mwaka A., Zoleko-Manego, Rella, Ouédragou, Smaïla, Briand, Valérie, Valá, Anifa, Kabanywanyi, Abdunoor M., Ouma, Peter, Massougbodji, Achille, Sevene, Esperança, Cot, Michel, Aponte, John J., Mayor, Alfredo, Slutsker, Laurence, Ramharter, Michael, Menéndez, Clara, and González, Raquel

Subjects
Pregnant girls -- Care and treatment -- Comparative analysis -- Statistics, Malaria -- Risk factors -- Statistics -- Patient outcomes, Pregnant women -- Comparative analysis -- Care and treatment -- Statistics, Biological sciences
Abstract

Background Malaria is among the top causes of death in adolescent girls (10 to 19 years) globally. Adolescent motherhood is associated with increased risk of adverse maternal and neonatal outcomes. The interaction of malaria, adolescence, and pregnancy is especially relevant in malaria endemic areas, where rates of adolescent pregnancy are high. However, data on burden of malaria among adolescent girls are limited. This study aimed at investigating whether adolescent girls were at a greater risk of experiencing malaria-related outcomes in pregnancy-parasitaemia and clinical disease-than adult women. Methods and findings An individual secondary participant-level meta-analysis was conducted using data from 5,804 pregnant women participating in 2 malaria prevention clinical trials in Benin, Gabon, Kenya, Mozambique, and Tanzania between 2009 and 2014. Of the sample, 1,201 participants were adolescent girls with a mean age of 17.5 years (standard deviation (SD) 1.3) and 886 (73.8%) of them primigravidae. Among the 4,603 adult women with mean age of 27.0 years (SD 5.4), 595 (12.9%) were primigravidae. Mean gestational age at enrolment was 20.2 weeks (SD 5.2) and 1,069 (18.4%) participants were HIV-infected. Women were followed monthly until the postpartum visit (1 month to 6 weeks after delivery). This study considered outcomes including clinical episodes during pregnancy, peripheral parasitaemia at delivery, and placental malaria. A 2-stage meta-analysis approach was followed by pooling single multivariable regression results into standard DerSimonian-Laird random-effects models. Adolescent girls were more likely than adult women to present with clinical malaria during pregnancy (incidence risk ratio (IRR) 1.70, 95% confidence interval (CI) 1.20; 2.39, p-value = 0.003, I.sup.2 = 0.0%, N = 4,092), peripheral parasitaemia at delivery (odds ratio (OR) 2.28, 95% CI 1.46; 3.55, p-value < 0.001, I.sup.2 = 0.0%, N = 3,977), and placental infection (OR 1.97, 95% CI 1.31; 2.98, p-value = 0.001, I.sup.2 = 1.4%, N = 4,797). Similar associations were observed among the subgroup of HIV-uninfected participants: IRR 1.72 (95% CI 1.22; 2.45, p-value = 0.002, I.sup.2 = 0.0%, N = 3,531) for clinical malaria episodes, OR 2.39 (95% CI 1.49; 3.86, p-value < 0.001, I.sup.2 = 0.0%, N = 3,053) for peripheral parasitaemia, and OR 1.88 (95% CI 1.06 to 3.33, p-value = 0.03, I.sup.2 = 34.9%, N = 3,847) for placental malaria. Among HIV-infected subgroups statistically significant associations were not observed. Similar associations were found in the subgroup analysis by gravidity. The small sample size and outcome prevalence in specific countries limited the inclusion of some countries in the meta-analysis. Furthermore, peripheral parasitaemia and placental malaria presented a considerable level of missing data-12.6% and 18.2% of participants had missing data on those outcomes, respectively. Given the original scope of the clinical trials, asymptomatic malaria infection was only assessed at the end of pregnancy through peripheral and placental parasitaemia. Conclusions In this study, we observed that adolescent girls in sub-Saharan Africa (SSA) are more prone to experience clinical malaria episodes during pregnancy and have peripheral malaria and placental infection at delivery than adult women. Moreover, to the best of our knowledge, for the first time this study disaggregates figures and stratifies analyses by HIV infection. Similar associations were found for both HIV-infected and uninfected women, although those for HIV-infected participants were not statistically significant. Our finding suggests that adolescent girls may benefit from targeted malaria prevention strategies even before they become pregnant., Author(s): Clara Pons-Duran 1,2, Ghyslain Mombo-Ngoma 3,4,5, Eusebio Macete 6, Meghna Desai 7, Mwaka A. Kakolwa 8, Rella Zoleko-Manego 3,4,5, Smaïla Ouédragou 9,10, Valérie Briand 11,12, Anifa Valá 6, Abdunoor [...]

Published
2022
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28. The effect of dosing strategies on the therapeutic efficacy of artesunate-amodiaquine for uncomplicated malaria: a meta-analysis of individual patient data.

Author

WorldWide Antimalarial Resistance Network (WWARN) AS-AQ Study Group, Adjuik, Martin A, Allan, Richard, Anvikar, Anupkumar R, Ashley, Elizabeth A, Ba, Mamadou S, Barennes, Hubert, Barnes, Karen I, Bassat, Quique, Baudin, Elisabeth, Björkman, Anders, Bompart, François, Bonnet, Maryline, Borrmann, Steffen, Brasseur, Philippe, Bukirwa, Hasifa, Checchi, Francesco, Cot, Michel, Dahal, Prabin, D'Alessandro, Umberto, Deloron, Philippe, Desai, Meghna, Diap, Graciela, Djimde, Abdoulaye A, Dorsey, Grant, Doumbo, Ogobara K, Espié, Emmanuelle, Etard, Jean-Francois, Fanello, Caterina I, Faucher, Jean-François, Faye, Babacar, Flegg, Jennifer A, Gaye, Oumar, Gething, Peter W, González, Raquel, Grandesso, Francesco, Guerin, Philippe J, Guthmann, Jean-Paul, Hamour, Sally, Hasugian, Armedy Ronny, Hay, Simon I, Humphreys, Georgina S, Jullien, Vincent, Juma, Elizabeth, Kamya, Moses R, Karema, Corine, Kiechel, Jean R, Kremsner, Peter G, Krishna, Sanjeev, Lameyre, Valérie, Ibrahim, Laminou M, Lee, Sue J, Lell, Bertrand, Mårtensson, Andreas, Massougbodji, Achille, Menan, Hervé, Ménard, Didier, Menéndez, Clara, Meremikwu, Martin, Moreira, Clarissa, Nabasumba, Carolyn, Nambozi, Michael, Ndiaye, Jean-Louis, Nikiema, Frederic, Nsanzabana, Christian, Ntoumi, Francine, Ogutu, Bernhards R, Olliaro, Piero, Osorio, Lyda, Ouédraogo, Jean-Bosco, Penali, Louis K, Pene, Mbaye, Pinoges, Loretxu, Piola, Patrice, Price, Ric N, Roper, Cally, Rosenthal, Philip J, Rwagacondo, Claude Emile, Same-Ekobo, Albert, Schramm, Birgit, Seck, Amadou, Sharma, Bhawna, Sibley, Carol Hopkins, Sinou, Véronique, Sirima, Sodiomon B, Smith, Jeffery J, Smithuis, Frank, Somé, Fabrice A, Sow, Doudou, Staedke, Sarah G, Stepniewska, Kasia, Swarthout, Todd D, Sylla, Khadime, Talisuna, Ambrose O, Tarning, Joel, Taylor, Walter RJ, Temu, Emmanuel A, Thwing, Julie I, Tjitra, Emiliana, and Tine, Roger CK

Subjects
WorldWide Antimalarial Resistance Network (WWARN) AS-AQ Study Group, Humans, Malaria, Falciparum, Recurrence, Artemisinins, Amodiaquine, Drug Combinations, Antimalarials, Treatment Outcome, Risk Factors, Dose-Response Relationship, Drug, Middle Aged, Africa, Female, Male, Malaria, Plasmodium falciparum, Drug resistance, Artesunate, Dosing, Efficacy, Falciparum, Dose-Response Relationship, Drug, Medical and Health Sciences, General & Internal Medicine
Abstract

BackgroundArtesunate-amodiaquine (AS-AQ) is one of the most widely used artemisinin-based combination therapies (ACTs) to treat uncomplicated Plasmodium falciparum malaria in Africa. We investigated the impact of different dosing strategies on the efficacy of this combination for the treatment of falciparum malaria.MethodsIndividual patient data from AS-AQ clinical trials were pooled using the WorldWide Antimalarial Resistance Network (WWARN) standardised methodology. Risk factors for treatment failure were identified using a Cox regression model with shared frailty across study sites.ResultsForty-three studies representing 9,106 treatments from 1999-2012 were included in the analysis; 4,138 (45.4%) treatments were with a fixed dose combination with an AQ target dose of 30 mg/kg (FDC), 1,293 (14.2%) with a non-fixed dose combination with an AQ target dose of 25 mg/kg (loose NFDC-25), 2,418 (26.6%) with a non-fixed dose combination with an AQ target dose of 30 mg/kg (loose NFDC-30), and the remaining 1,257 (13.8%) with a co-blistered non-fixed dose combination with an AQ target dose of 30 mg/kg (co-blistered NFDC). The median dose of AQ administered was 32.1 mg/kg [IQR: 25.9-38.2], the highest dose being administered to patients treated with co-blistered NFDC (median = 35.3 mg/kg [IQR: 30.6-43.7]) and the lowest to those treated with loose NFDC-25 (median = 25.0 mg/kg [IQR: 22.7-25.0]). Patients treated with FDC received a median dose of 32.4 mg/kg [IQR: 27-39.0]. After adjusting for reinfections, the corrected antimalarial efficacy on day 28 after treatment was similar for co-blistered NFDC (97.9% [95% confidence interval (CI): 97.0-98.8%]) and FDC (98.1% [95% CI: 97.6%-98.5%]; P = 0.799), but significantly lower for the loose NFDC-25 (93.4% [95% CI: 91.9%-94.9%]), and loose NFDC-30 (95.0% [95% CI: 94.1%-95.9%]) (P

Published
2015

29. Absence of Putative Artemisinin Resistance Mutations Among Plasmodium falciparum in Sub-Saharan Africa: A Molecular Epidemiologic Study

Author

Taylor, Steve M, Parobek, Christian M, DeConti, Derrick K, Kayentao, Kassoum, Coulibaly, Sheick Oumar, Greenwood, Brian M, Tagbor, Harry, Williams, John, Bojang, Kalifa, Njie, Fanta, Desai, Meghna, Kariuki, Simon, Gutman, Julie, Mathanga, Don P, Mårtensson, Andreas, Ngasala, Billy, Conrad, Melissa D, Rosenthal, Philip J, Tshefu, Antoinette K, Moormann, Ann M, Vulule, John M, Doumbo, Ogobara K, Kuile, Feiko O ter, Meshnick, Steven R, Bailey, Jeffrey A, and Juliano, Jonathan J

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Prevention, Vector-Borne Diseases, Rare Diseases, Antimicrobial Resistance, Genetics, Infectious Diseases, Biodefense, Vaccine Related, Malaria, Aetiology, 2.1 Biological and endogenous factors, 2.2 Factors relating to the physical environment, Infection, Good Health and Well Being, Adult, Africa South of the Sahara, Antimalarials, Artemisinins, Child, Child, Preschool, Female, Gene Frequency, Genotype, High-Throughput Nucleotide Sequencing, Humans, Malaria, Falciparum, Male, Molecular Epidemiology, Mutation, Plasmodium falciparum, Polymorphism, Genetic, Pregnancy, Prevalence, falciparum malaria, artemisinin resistance, drug resistance, molecular epidemiology, Biological Sciences, Medical and Health Sciences, Microbiology, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Plasmodium falciparum parasites that are resistant to artemisinins have been detected in Southeast Asia. Resistance is associated with several polymorphisms in the parasite's K13-propeller gene. The molecular epidemiology of these artemisinin resistance genotypes in African parasite populations is unknown. We developed an assay to quantify rare polymorphisms in parasite populations that uses a pooled deep-sequencing approach to score allele frequencies, validated it by evaluating mixtures of laboratory parasite strains, and then used it to screen P. falciparum parasites from >1100 African infections collected since 2002 from 14 sites across sub-Saharan Africa. We found no mutations in African parasite populations that are associated with artemisinin resistance in Southeast Asian parasites. However, we observed 15 coding mutations, including 12 novel mutations, and limited allele sharing between parasite populations, consistent with a large reservoir of naturally occurring K13-propeller variation. Although polymorphisms associated with artemisinin resistance in P. falciparum in Southeast Asia are not prevalent in sub-Saharan Africa, numerous K13-propeller coding polymorphisms circulate in Africa. Although their distributions do not support a widespread selective sweep for an artemisinin-resistant phenotype, the impact of these mutations on artemisinin susceptibility is unknown and will require further characterization. Rapid, scalable molecular surveillance offers a useful adjunct in tracking and containing artemisinin resistance.

Published
2015

30. Effect of Plasmodium falciparum sulfadoxine-pyrimethamine resistance on the effectiveness of intermittent preventive therapy for malaria in pregnancy in Africa: a systematic review and meta-analysis

Author

van Eijk, Anna Maria, Larsen, David A, Kayentao, Kassoum, Koshy, Gibby, Slaughter, Douglas E C, Roper, Cally, Okell, Lucy C, Desai, Meghna, Gutman, Julie, Khairallah, Carole, Rogerson, Stephen J, Hopkins Sibley, Carol, Meshnick, Steven R, Taylor, Steve M, and ter Kuile, Feiko O

Published
2019
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31. Deep-Sea Sponges and Corals off the Western Coast of Florida—Intracellular Mechanisms of Action of Bioactive Compounds and Technological Advances Supporting the Drug Discovery Pipeline

Author

Iskandar, Mina, primary, Ruiz-Houston, Kira M., additional, Bracco, Steven D., additional, Sharkasi, Sami R., additional, Calabi Villarroel, Cecilia L., additional, Desai, Meghna N., additional, Gerges, Alexandra G., additional, Ortiz Lopez, Natalia A., additional, Xiao Barbero, Miguel, additional, German, Amelia A., additional, Moluguri, Vinoothna S., additional, Walker, Selina M., additional, Silva Higashi, Juliana, additional, Palma, Justin M., additional, Medina, Daena Z., additional, Patel, Miit, additional, Patel, Prachi, additional, Valentin, Michaela, additional, Diaz, Angelica C., additional, Karthaka, Jonathan P., additional, Santiago, Atzin D., additional, Skiles, Riley B., additional, Romero Umana, Luis A., additional, Ungrey, Maxwell D., additional, Wojtkowiak, Anya, additional, Howard, Domenica V., additional, Nurge, Remy, additional, Woods, Katharine G., additional, and Nanjundan, Meera, additional

Published
2023
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34. Safety and mosquitocidal efficacy of high-dose ivermectin when co-administered with dihydroartemisinin-piperaquine in Kenyan adults with uncomplicated malaria (IVERMAL): a randomised, double-blind, placebo-controlled trial

Author

Smit, Menno R, Ochomo, Eric O, Aljayyoussi, Ghaith, Kwambai, Titus K, Abong'o, Bernard O, Chen, Tao, Bousema, Teun, Slater, Hannah C, Waterhouse, David, Bayoh, Nabie M, Gimnig, John E, Samuels, Aaron M, Desai, Meghna R, Phillips-Howard, Penelope A, Kariuki, Simon K, Wang, Duolao, Ward, Steve A, and ter Kuile, Feiko O

Published
2018
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35. Prevention of malaria in pregnancy

Author

Desai, Meghna, Hill, Jenny, Fernandes, Silke, Walker, Patrick, Pell, Christopher, Gutman, Julie, Kayentao, Kassoum, Gonzalez, Raquel, Webster, Jayne, Greenwood, Brian, Cot, Michel, and ter Kuile, Feiko O

Published
2018
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37. VAR2CSA Serology to Detect Plasmodium falciparum Transmission Patterns in Pregnancy

Author

Fonseca, Ana Maria, Gonzalez, Raquel, Bardaji, Azucena, Jairoce, Chenjerai, Ruperez, Maria, Jimenez, Alfons, Quinto, Llorenc, Cistero, Pau, Vala, Anifa, Sacoor, Charfudin, Gupta, Himanshu, Hegewisch-Taylor, Jennifer, Brew, Joe, Ndam, Nicaise Tuikue, Kariuki, Simon, Lopez, Marta, Dobano, Carlota, Chitnis, Chetan E., Ouma, Peter, Ramharter, Michael, Abdulla, Salim, Aponte, John J., Massougbodji, Achille, Briand, Valerie, Mombo-Ngoma, Ghyslain, Desai, Meghna, Cot, Michel, Nhacolo, Arsenio, Sevene, Esperanca, Macete, Eusebio, Menendez, Clara, and Mayor, Alfredo

Subjects
Disease transmission -- Health aspects, Peptides -- Health aspects, Medical research -- Health aspects, Infection -- Health aspects, Plasmodium falciparum -- Health aspects, Malaria -- Health aspects, Pregnancy -- Health aspects, Immune response -- Health aspects, EDTA -- Health aspects, Pregnant women -- Health aspects, Immunoglobulin G -- Health aspects, Antigens, Antibodies, Health
Abstract

Agile malaria surveillance and response systems that can be sustained over time are needed for the optimal design of control programs (1,2). Rates of Plasmodium falciparum infection among pregnant women [...]

Published
2019
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40. Post-Discharge Risk of Mortality in Children under 5 Years of Age in Western Kenya: A Retrospective Cohort Study

Author

Kwambai, Titus K., primary, Kariuki, Simon, additional, Smit, Menno R., additional, Nevitt, Sarah, additional, Onyango, Eric, additional, Oneko, Martina, additional, Khagayi, Sammy, additional, Samuels, Aaron M., additional, Hamel, Mary J., additional, Laserson, Kayla, additional, Desai, Meghna, additional, and ter Kuile, Feiko O., additional

Published
2023
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42. Modelling the incremental benefit of introducing malaria screening strategies to antenatal care in Africa

Author

Walker, Patrick G. T., Cairns, Matt, Slater, Hannah, Gutman, Julie, Kayentao, Kassoum, Williams, John E., Coulibaly, Sheick O., Khairallah, Carole, Taylor, Steve, Meshnick, Steven R., Hill, Jenny, Mwapasa, Victor, Kalilani-Phiri, Linda, Bojang, Kalifa, Kariuki, Simon, Tagbor, Harry, Griffin, Jamie T., Madanitsa, Mwayi, Ghani, Azra C. H., Desai, Meghna, and ter Kuile, Feiko O.

Published
2020
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45. Impact of Sulfadoxine-Pyrimethamine Resistance on Effectiveness of Intermittent Preventive Therapy for Malaria in Pregnancy at Clearing Infections and Preventing Low Birth Weight

Author

Desai, Meghna, Gutman, Julie, Taylor, Steve M., Wiegand, Ryan E., Khairallah, Carole, Kayentao, Kassoum, Ouma, Peter, Coulibaly, Sheick O., Kalilani, Linda, Mace, Kimberly E., Arinaitwe, Emmanuel, Mathanga, Don P., Doumbo, Ogobara, Otieno, Kephas, Edgar, Dabira, Chaluluka, Ebbie, Kamuliwo, Mulakwa, Ades, Veronica, Skarbinski, Jacek, Shi, Ya Ping, Magnussen, Pascal, Meshnick, Steve, and ter Kuile, Feiko O.

Published
2016

46. Intermittent screening and treatment or intermittent preventive treatment with dihydroartemisinin–piperaquine versus intermittent preventive treatment with sulfadoxine–pyrimethamine for the control of malaria during pregnancy in western Kenya: an open-label, three-group, randomised controlled superiority trial

Author

Desai, Meghna, Gutman, Julie, L'lanziva, Anne, Otieno, Kephas, Juma, Elizabeth, Kariuki, Simon, Ouma, Peter, Were, Vincent, Laserson, Kayla, Katana, Abraham, Williamson, John, and ter Kuile, Feiko O

Published
2015
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47. Community-based intermittent mass testing and treatment for malaria in an area of high transmission intensity, western Kenya: development of study site infrastructure and lessons learned

Author

Odero, Norbert Awino, Samuels, Aaron M., Odongo, Wycliffe, Abong’o, Bernard, Gimnig, John, Otieno, Kephas, Odero, Christopher, Obor, David, Ombok, Maurice, Were, Vincent, Sang, Tony, Hamel, Mary J., Kachur, S. Patrick, Slutsker, Laurence, Lindblade, Kim A., Kariuki, Simon, and Desai, Meghna

Published
2019
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