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Your search keyword '"DesRochers, Laura"' showing total 26 results
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26 results on '"DesRochers, Laura"'

5. Functional brain connectivity after corrective cardiac surgery for critical congenital heart disease: a preliminary near-infrared spectroscopy (NIRS) report.

Author

Fourdain, Solène, Provost, Sarah, Tremblay, Julie, Vannasing, Phetsamone, Doussau, Amélie, Caron-Desrochers, Laura, Gaudet, Isabelle, Roger, Kassandra, Hüsser, Alejandra, Dehaes, Mathieu, Martinez-Montes, Eduardo, Poirier, Nancy, and Gallagher, Anne

Subjects
CONGENITAL heart disease, NEAR infrared spectroscopy, FUNCTIONAL connectivity, FUNCTIONAL magnetic resonance imaging, CARDIAC surgery, CARDIAC patients, DIAGNOSTIC imaging
Abstract

Patients with congenital heart disease (CHD) requiring cardiac surgery in infancy are at high risk for neurodevelopmental impairments. Neonatal imaging studies have reported disruptions of brain functional organization before surgery. Yet, the extent to which functional network alterations are present after cardiac repair remains unexplored. This preliminary study aimed at investigating cortical functional connectivity in 4-month-old infants with repaired CHD, using resting-state functional near-infrared spectroscopy (fNIRS). After fNIRS signal frequency decomposition, we compared values of magnitude-squared coherence as a measure of connectivity strength, between 21 infants with corrected CHD and 31 healthy controls. We identified a subset of connections with differences between groups at an uncorrected statistical level of p <.05 while controlling for sex and maternal socioeconomic status, with most of these connections showing reduced connectivity in infants with CHD. Although none of these differences reach statistical significance after FDR correction, likely due to the small sample size, moderate to large effect sizes were found for group-differences. If replicated, these results would therefore suggest preliminary evidence that alterations of brain functional connectivity are present in the months after cardiac surgery. Additional studies involving larger sample size are needed to replicate our data, and comparisons between pre- and postoperative findings would allow to further delineate alterations of functional brain connectivity in this population. [ABSTRACT FROM AUTHOR]

Published
2023
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8. LIONirs: flexible Matlab toolbox for fNIRS data analysis

Author

Tremblay, Julie, primary, Martínez-Montes, Eduardo, additional, Hüsser, Alejandra, additional, Caron-Desrochers, Laura, additional, Lepage, Charles, additional, Pouliot, Philippe, additional, Vannasing, Phetsamone, additional, and Gallagher, Anne, additional

Published
2022
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9. Neurotoxin-mediated --potent activation of the axon degeneration regulator SARM1

Author

Loreto, Andrea, Angeletti, Carlo, Gu, Weixi, Osborne, Andrew, Nieuwenhuis, Bart, Gilley, Jonathan, Merlini, Elisa, Arthur-Farraj, Peter, Amici, Adolfo, Luo, Zhenyao, Hartley-Tassell, Lauren, Ve, Thomas, Desrochers, Laura M, Wang, Qi, Kobe, Bostjan, Orsomando, Giuseppe, Coleman, Michael, Loreto, Andrea [0000-0001-6535-6436], Nieuwenhuis, Bart [0000-0002-2065-2271], Arthur-Farraj, Peter [0000-0002-1239-9392], Coleman, Michael [0000-0002-9354-532X], Apollo - University of Cambridge Repository, Gu, Weixi [0000-0002-1185-3557], Gilley, Jonathan [0000-0002-9510-7956], Amici, Adolfo [0000-0002-1081-7749], Kobe, Bostjan [0000-0001-9413-9166], and Orsomando, Giuseppe [0000-0001-6640-097X]

Subjects
Male, SARM1, QH301-705.5, Science, Neurotoxins, vacor, chemical biology, General Biochemistry, Genetics and Molecular Biology, neuroscience, Mice, Biochemistry and Chemical Biology, Animals, biochemistry, Biology (General), mouse, Armadillo Domain Proteins, General Immunology and Microbiology, General Neuroscience, Phenylurea Compounds, Rodenticides, General Medicine, VMN, NAD, Axons, axon degeneration, Cytoskeletal Proteins, nervous system, environmental neurotoxin, Nerve Degeneration, Medicine, Female, Research Article
Abstract

Axon loss underlies symptom onset and progression in many neurodegenerative disorders. Axon degeneration in injury and disease is promoted by activation of the NAD-consuming enzyme SARM1. Here, we report a novel activator of SARM1, a metabolite of the pesticide and neurotoxin vacor. Removal of SARM1 completely rescues mouse neurons from vacor-induced neuron and axon death in vitro and in vivo. We present the crystal structure of the Drosophila SARM1 regulatory domain complexed with this activator, the vacor metabolite VMN, which as the most potent activator yet known is likely to support drug development for human SARM1 and NMNAT2 disorders. This study indicates the mechanism of neurotoxicity and pesticide action by vacor, raises important questions about other pyridines in wider use today, provides important new tools for drug discovery, and demonstrates that removing SARM1 can robustly block programmed axon death induced by toxicity as well as genetic mutation.

Published
2021

11. Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1

Author

Loreto, Andrea, primary, Angeletti, Carlo, primary, Gu, Weixi, additional, Osborne, Andrew, additional, Nieuwenhuis, Bart, additional, Gilley, Jonathan, additional, Merlini, Elisa, additional, Arthur-Farraj, Peter, additional, Amici, Adolfo, additional, Luo, Zhenyao, additional, Hartley-Tassell, Lauren, additional, Ve, Thomas, additional, Desrochers, Laura M, additional, Wang, Qi, additional, Kobe, Bostjan, additional, Orsomando, Giuseppe, additional, and Coleman, Michael P, additional

Published
2021
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12. Author response: Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1

Author

Loreto, Andrea, primary, Angeletti, Carlo, primary, Gu, Weixi, additional, Osborne, Andrew, additional, Nieuwenhuis, Bart, additional, Gilley, Jonathan, additional, Merlini, Elisa, additional, Arthur-Farraj, Peter, additional, Amici, Adolfo, additional, Luo, Zhenyao, additional, Hartley-Tassell, Lauren, additional, Ve, Thomas, additional, Desrochers, Laura M, additional, Wang, Qi, additional, Kobe, Bostjan, additional, Orsomando, Giuseppe, additional, and Coleman, Michael P, additional

Published
2021
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16. Impacts of an Interdisciplinary Developmental Follow-Up Program on Neurodevelopment in Congenital Heart Disease: The CINC Study

Author

Fourdain, Solène, primary, Caron-Desrochers, Laura, additional, Simard, Marie-Noëlle, additional, Provost, Sarah, additional, Doussau, Amélie, additional, Gagnon, Karine, additional, Dagenais, Lynn, additional, Presutto, Émilie, additional, Prud'homme, Joëlle, additional, Boudreault-Trudeau, Annabelle, additional, Constantin, Ioana Medeleine, additional, Desnous, Béatrice, additional, Poirier, Nancy, additional, and Gallagher, Anne, additional

Published
2020
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17. Potent activation of SARM1 by NMN analogue VMN underlies vacor neurotoxicity

Author

Loreto, Andrea, primary, Angeletti, Carlo, additional, Gu, Weixi, additional, Osborne, Andrew, additional, Nieuwenhuis, Bart, additional, Gilley, Jonathan, additional, Arthur-Farraj, Peter, additional, Merlini, Elisa, additional, Amici, Adolfo, additional, Luo, Zhenyao, additional, Hartley-Tassell, Lauren, additional, Ve, Thomas, additional, Desrochers, Laura M., additional, Wang, Qi, additional, Kobe, Bostjan, additional, Orsomando, Giuseppe, additional, and Coleman, Michael P., additional

Published
2020
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23. Enhanced brainstem and cortical encoding of sound during synchronized movement.

Author

UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience, Nozaradan, Sylvie, Schönwiesner, Marc, Caron-Desrochers, Laura, Lehmann, Alexandre, UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience, Nozaradan, Sylvie, Schönwiesner, Marc, Caron-Desrochers, Laura, and Lehmann, Alexandre

Abstract

Movement to a steady beat has been widely studied as a model of alignment of motor outputs on sensory inputs. However, how the encoding of sensory inputs is shaped during synchronized movements along the sensory pathway remains unknown. To investigate this, we simultaneously recorded brainstem and cortical electro-encephalographic activity while participants listened to periodic amplitude-modulated tones. Participants listened either without moving or while tapping in sync on every second beat. Cortical responses were identified at the envelope modulation rate (beat frequency), whereas brainstem responses were identified at the partials frequencies of the chord and at their modulation by the beat frequency (sidebands). During sensorimotor synchronization, cortical responses at beat frequency were larger than during passive listening. Importantly, brainstem responses were also enhanced, with a selective amplification of the sidebands, in particular at the lower-pitched tone of the chord, and no significant correlation with electromyographic measures at tapping frequency. These findings provide first evidence for an online gain in the cortical and subcortical encoding of sounds during synchronized movement, selective to behavior-relevant sound features. Moreover, the frequency-tagging method to isolate concurrent brainstem and cortical activities even during actual movements appears promising to reveal coordinated processes along the human auditory pathway.

Published
2016

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