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1. Author Correction: GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability

Author

Pasman, Joëlle A, Verweij, Karin JH, Gerring, Zachary, Stringer, Sven, Sanchez-Roige, Sandra, Treur, Jorien L, Abdellaoui, Abdel, Nivard, Michel G, Baselmans, Bart ML, Ong, Jue-Sheng, Ip, Hill F, van der Zee, Matthijs D, Bartels, Meike, Day, Felix R, Fontanillas, Pierre, Elson, Sarah L, de Wit, Harriet, Davis, Lea K, MacKillop, James, Derringer, Jaime L, Branje, Susan JT, Hartman, Catharina A, Heath, Andrew C, van Lier, Pol AC, Madden, Pamela AF, Mägi, Reedik, Meeus, Wim, Montgomery, Grant W, Oldehinkel, AJ, Pausova, Zdenka, Ramos-Quiroga, Josep A, Paus, Tomas, Ribases, Marta, Kaprio, Jaakko, Boks, Marco PM, Bell, Jordana T, Spector, Tim D, Gelernter, Joel, Boomsma, Dorret I, Martin, Nicholas G, MacGregor, Stuart, Perry, John RB, Palmer, Abraham A, Posthuma, Danielle, Munafò, Marcus R, Gillespie, Nathan A, Derks, Eske M, and Vink, Jacqueline M

Subjects
Biological Psychology, Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Psychology, Drug Abuse (NIDA only), Human Genome, Brain Disorders, Serious Mental Illness, Genetics, Schizophrenia, Substance Misuse, Mental Health, 2.1 Biological and endogenous factors, Aetiology, Mental health, 23andMe Research Team, Substance Use Disorders Working Group of the Psychiatric Genomics Consortium, International Cannabis Consortium, Neurosciences, Cognitive Sciences, Neurology & Neurosurgery, Biological psychology
Abstract

Several occurrences of the word 'schizophrenia' have been re-worded as 'liability to schizophrenia' or 'schizophrenia risk', including in the title, which should have been "GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability," as well as in Supplementary Figures 1-10 and Supplementary Tables 7-10, to more accurately reflect the findings of the work.

Published
2019

2. GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability

Author

Pasman, Joëlle A, Verweij, Karin JH, Gerring, Zachary, Stringer, Sven, Sanchez-Roige, Sandra, Treur, Jorien L, Abdellaoui, Abdel, Nivard, Michel G, Baselmans, Bart ML, Ong, Jue-Sheng, Ip, Hill F, van der Zee, Matthijs D, Bartels, Meike, Day, Felix R, Fontanillas, Pierre, Elson, Sarah L, the 23andMe Research Team, de Wit, Harriet, Davis, Lea K, MacKillop, James, The Substance Use Disorders Working Group of the Psychiatric Genomics Consortium, International Cannabis Consortium, Derringer, Jaime L, Branje, Susan JT, Hartman, Catharina A, Heath, Andrew C, van Lier, Pol AC, Madden, Pamela AF, Mägi, Reedik, Meeus, Wim, Montgomery, Grant W, Oldehinkel, AJ, Pausova, Zdenka, Ramos-Quiroga, Josep A, Paus, Tomas, Ribases, Marta, Kaprio, Jaakko, Boks, Marco PM, Bell, Jordana T, Spector, Tim D, Gelernter, Joel, Boomsma, Dorret I, Martin, Nicholas G, MacGregor, Stuart, Perry, John RB, Palmer, Abraham A, Posthuma, Danielle, Munafò, Marcus R, Gillespie, Nathan A, Derks, Eske M, and Vink, Jacqueline M

Subjects
Biological Psychology, Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Psychology, Prevention, Mental Health, Schizophrenia, Clinical Research, Behavioral and Social Science, Genetics, Mental Illness, Brain Disorders, Serious Mental Illness, Human Genome, Drug Abuse (NIDA only), Women's Health, Cannabinoid Research, Substance Misuse, 2.1 Biological and endogenous factors, Mental health, Good Health and Well Being, Adolescent, Adult, Aged, Aged, 80 and over, Cell Adhesion Molecules, Databases, Genetic, Female, Gene Expression Regulation, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Male, Marijuana Abuse, Mendelian Randomization Analysis, Middle Aged, Polymorphism, Single Nucleotide, Risk-Taking, Young Adult, 23andMe Research Team, Substance Use Disorders Working Group of the Psychiatric Genomics Consortium, International Cannabis Consortium, Neurosciences, Cognitive Sciences, Neurology & Neurosurgery, Biological psychology
Abstract

Cannabis use is a heritable trait that has been associated with adverse mental health outcomes. In the largest genome-wide association study (GWAS) for lifetime cannabis use to date (N = 184,765), we identified eight genome-wide significant independent single nucleotide polymorphisms in six regions. All measured genetic variants combined explained 11% of the variance. Gene-based tests revealed 35 significant genes in 16 regions, and S-PrediXcan analyses showed that 21 genes had different expression levels for cannabis users versus nonusers. The strongest finding across the different analyses was CADM2, which has been associated with substance use and risk-taking. Significant genetic correlations were found with 14 of 25 tested substance use and mental health-related traits, including smoking, alcohol use, schizophrenia and risk-taking. Mendelian randomization analysis showed evidence for a causal positive influence of schizophrenia risk on cannabis use. Overall, our study provides new insights into the etiology of cannabis use and its relation with mental health.

Published
2018

3. GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia.

Author

Pasman, Joëlle A, Verweij, Karin JH, Gerring, Zachary, Stringer, Sven, Sanchez-Roige, Sandra, Treur, Jorien L, Abdellaoui, Abdel, Nivard, Michel G, Baselmans, Bart ML, Ong, Jue-Sheng, Ip, Hill F, van der Zee, Matthijs D, Bartels, Meike, Day, Felix R, Fontanillas, Pierre, Elson, Sarah L, 23andMe Research Team, de Wit, Harriet, Davis, Lea K, MacKillop, James, Substance Use Disorders Working Group of the Psychiatric Genomics Consortium, International Cannabis Consortium, Derringer, Jaime L, Branje, Susan JT, Hartman, Catharina A, Heath, Andrew C, van Lier, Pol AC, Madden, Pamela AF, Mägi, Reedik, Meeus, Wim, Montgomery, Grant W, Oldehinkel, AJ, Pausova, Zdenka, Ramos-Quiroga, Josep A, Paus, Tomas, Ribases, Marta, Kaprio, Jaakko, Boks, Marco PM, Bell, Jordana T, Spector, Tim D, Gelernter, Joel, Boomsma, Dorret I, Martin, Nicholas G, MacGregor, Stuart, Perry, John RB, Palmer, Abraham A, Posthuma, Danielle, Munafò, Marcus R, Gillespie, Nathan A, Derks, Eske M, and Vink, Jacqueline M

Subjects
23andMe Research Team, Substance Use Disorders Working Group of the Psychiatric Genomics Consortium, International Cannabis Consortium, Humans, Marijuana Abuse, Genetic Predisposition to Disease, Cell Adhesion Molecules, Risk-Taking, Mental Health, Schizophrenia, Gene Expression Regulation, Genotype, Polymorphism, Single Nucleotide, Databases, Genetic, Adolescent, Adult, Aged, Aged, 80 and over, Middle Aged, Female, Male, Genome-Wide Association Study, Young Adult, Mendelian Randomization Analysis, Polymorphism, Single Nucleotide, Databases, Genetic, and over, Prevention, Human Genome, Brain Disorders, Drug Abuse, Substance Abuse, Genetics, Clinical Research, 2.1 Biological and endogenous factors, Cardiovascular, Neurology & Neurosurgery, Neurosciences, Cognitive Sciences, Psychology
Abstract

Cannabis use is a heritable trait that has been associated with adverse mental health outcomes. In the largest genome-wide association study (GWAS) for lifetime cannabis use to date (N = 184,765), we identified eight genome-wide significant independent single nucleotide polymorphisms in six regions. All measured genetic variants combined explained 11% of the variance. Gene-based tests revealed 35 significant genes in 16 regions, and S-PrediXcan analyses showed that 21 genes had different expression levels for cannabis users versus nonusers. The strongest finding across the different analyses was CADM2, which has been associated with substance use and risk-taking. Significant genetic correlations were found with 14 of 25 tested substance use and mental health-related traits, including smoking, alcohol use, schizophrenia and risk-taking. Mendelian randomization analysis showed evidence for a causal positive influence of schizophrenia risk on cannabis use. Overall, our study provides new insights into the etiology of cannabis use and its relation with mental health.

Published
2018

5. Longevity candidate genes and their association with personality traits in the elderly

Author

Luciano, Michelle, Lopez, Lorna M., de Moor, Marleen H.M., Harris, Sarah E., Davies, Gail, Nutile, Teresa, Krueger, Robert F., Esko, Tõnu, Schlessinger, David, Toshiko, Tanaka, Derringer, Jaime L., Realo, Anu, Hansell, Narelle K., Pergadia, Michele L., Pesonen, Anu-Katriina, Sanna, Serena, Terracciano, Antonio, Madden, Pamela A.F., Penninx, Brenda, Spinhoven, Philip, Hartman, Catherina A., Oostra, Ben A., Janssens, Cecile A.J.W., Eriksson, Johan G., Starr, John M., Cannas, Alessandra, Ferrucci, Luigi, Metspalu, Andres, Wright, Margeret J., Heath, Andrew C., van Duijn, Cornelia M., Bierut, Laura J., Raikkonen, Katri, Martin, Nicholas G., Ciullo, Marina, Rujescu, Dan, Boomsma, Dorret I., and Deary, Ian J.

Published
2012
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6. Author Correction: GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability (Nature Neuroscience, (2018), 21, 9, (1161-1170), 10.1038/s41593-018-0206-1)

Author

Pasman, Joëlle A., Verweij, Karin J. H., Gerring, Zachary, Stringer, Sven, Sanchez-Roige, Sandra, Treur, Jorien L., Abdellaoui, Abdel, Nivard, Michel G., Baselmans, Bart M. L., Ong, Jue-Sheng, Ip, Hill F., van der Zee, Matthijs D., Bartels, Meike, Day, Felix R., Fontanillas, Pierre, Elson, Sarah L., de Wit, Harriet, Davis, Lea K., MacKillop, James, Derringer, Jaime L., Branje, Susan J. T., Hartman, Catharina A., Heath, Andrew C., van Lier, Pol A. C., Madden, Pamela A. F., Mägi, Reedik, Meeus, Wim, Montgomery, Grant W., Oldehinkel, A. J., Pausova, Zdenka, Ramos-Quiroga, Josep A., Paus, Tomas, Ribases, Marta, Kaprio, Jaakko, Boks, Marco P. M., Bell, Jordana T., Spector, Tim D., Gelernter, Joel, Boomsma, Dorret I., Martin, Nicholas G., MacGregor, Stuart, Perry, John R. B., Palmer, Abraham A., Posthuma, Danielle, Munafò, Marcus R., Gillespie, Nathan A., Derks, Eske M., and Vink, Jacqueline M.

Subjects
mental disorders, behavioral disciplines and activities
Abstract

Several occurrences of the word ‘schizophrenia’ have been re-worded as ‘liability to schizophrenia’ or ‘schizophrenia risk’, including in the title, which should have been “GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability,” as well as in Supplementary Figures 1–10 and Supplementary Tables 7–10, to more accurately reflect the findings of the work.

Published
2019

7. GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia

Author

Pasman, Joëlle A., Verweij, Karin J. H., Gerring, Zachary, Stringer, Sven, Sanchez-roige, Sandra, Treur, Jorien L., Abdellaoui, Abdel, Nivard, Michel G., Baselmans, Bart M. L., Ong, Jue-sheng, Ip, Hill F., Van Der Zee, Matthijs D., Bartels, Meike, Day, Felix R., Fontanillas, Pierre, Elson, Sarah L., De Wit, Harriet, Davis, Lea K., Mackillop, James, Derringer, Jaime L., Branje, Susan J. T., Hartman, Catharina A., Heath, Andrew C., Van Lier, Pol A. C., Madden, Pamela A. F., Mägi, Reedik, Meeus, Wim, Montgomery, Grant W., Oldehinkel, A. J., Pausova, Zdenka, Ramos-quiroga, Josep A., Paus, Tomas, Ribases, Marta, Kaprio, Jaakko, Boks, Marco P. M., Bell, Jordana T., Spector, Tim D., Gelernter, Joel, Boomsma, Dorret I., Martin, Nicholas G., Macgregor, Stuart, Perry, John R. B., Palmer, Abraham A., Posthuma, Danielle, Munafò, Marcus R., Gillespie, Nathan A., Derks, Eske M., Vink, Jacqueline M., Leerstoel Branje, and Adolescent development: Characteristics and determinants

Subjects
Taverne
Abstract

Cannabis use is a heritable trait that has been associated with adverse mental health outcomes. In the largest genome-wide association study (GWAS) for lifetime cannabis use to date (N = 184,765), we identified eight genome-wide significant independent single nucleotide polymorphisms in six regions. All measured genetic variants combined explained 11% of the variance. Gene-based tests revealed 35 significant genes in 16 regions, and S-PrediXcan analyses showed that 21 genes had different expression levels for cannabis users versus nonusers. The strongest finding across the different analyses was CADM2, which has been associated with substance use and risk-taking. Significant genetic correlations were found with 14 of 25 tested substance use and mental health–related traits, including smoking, alcohol use, schizophrenia and risk-taking. Mendelian randomization analysis showed evidence for a causal positive influence of schizophrenia risk on cannabis use. Overall, our study provides new insights into the etiology of cannabis use and its relation with mental health.

Published
2018

8. GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia

Author

Leerstoel Branje, Adolescent development: Characteristics and determinants, Pasman, Joëlle A., Verweij, Karin J. H., Gerring, Zachary, Stringer, Sven, Sanchez-roige, Sandra, Treur, Jorien L., Abdellaoui, Abdel, Nivard, Michel G., Baselmans, Bart M. L., Ong, Jue-sheng, Ip, Hill F., Van Der Zee, Matthijs D., Bartels, Meike, Day, Felix R., Fontanillas, Pierre, Elson, Sarah L., De Wit, Harriet, Davis, Lea K., Mackillop, James, Derringer, Jaime L., Branje, Susan J. T., Hartman, Catharina A., Heath, Andrew C., Van Lier, Pol A. C., Madden, Pamela A. F., Mägi, Reedik, Meeus, Wim, Montgomery, Grant W., Oldehinkel, A. J., Pausova, Zdenka, Ramos-quiroga, Josep A., Paus, Tomas, Ribases, Marta, Kaprio, Jaakko, Boks, Marco P. M., Bell, Jordana T., Spector, Tim D., Gelernter, Joel, Boomsma, Dorret I., Martin, Nicholas G., Macgregor, Stuart, Perry, John R. B., Palmer, Abraham A., Posthuma, Danielle, Munafò, Marcus R., Gillespie, Nathan A., Derks, Eske M., Vink, Jacqueline M., Leerstoel Branje, Adolescent development: Characteristics and determinants, Pasman, Joëlle A., Verweij, Karin J. H., Gerring, Zachary, Stringer, Sven, Sanchez-roige, Sandra, Treur, Jorien L., Abdellaoui, Abdel, Nivard, Michel G., Baselmans, Bart M. L., Ong, Jue-sheng, Ip, Hill F., Van Der Zee, Matthijs D., Bartels, Meike, Day, Felix R., Fontanillas, Pierre, Elson, Sarah L., De Wit, Harriet, Davis, Lea K., Mackillop, James, Derringer, Jaime L., Branje, Susan J. T., Hartman, Catharina A., Heath, Andrew C., Van Lier, Pol A. C., Madden, Pamela A. F., Mägi, Reedik, Meeus, Wim, Montgomery, Grant W., Oldehinkel, A. J., Pausova, Zdenka, Ramos-quiroga, Josep A., Paus, Tomas, Ribases, Marta, Kaprio, Jaakko, Boks, Marco P. M., Bell, Jordana T., Spector, Tim D., Gelernter, Joel, Boomsma, Dorret I., Martin, Nicholas G., Macgregor, Stuart, Perry, John R. B., Palmer, Abraham A., Posthuma, Danielle, Munafò, Marcus R., Gillespie, Nathan A., Derks, Eske M., and Vink, Jacqueline M.

Published
2018

10. Longevity candidate genes and their association with personality traits in the elderly

Author

Luciano, Michelle, Lopez, Lorna M., de Moor, Marleen H.M., Harris, Sarah E., Davies, Gail, Nutile, Teresa, Krueger, Robert F., Esko, Tõnu, Schlessinger, David, Toshiko, Tanaka, Derringer, Jaime L., Realo, Anu, Hansell, Narelle K., Pergadia, Michele L., Pesonen, Anu-Katriina, Sanna, Serena, Terracciano, Antonio, Madden, Pamela A.F., Penninx, Brenda, Spinhoven, Philip, Hartman, Catherina A., Oostra, Ben A., Janssens, A. Cecile J.W., Eriksson, Johan G., Starr, John M., Cannas, Alessandra, Ferrucci, Luigi, Metspalu, Andres, Wright, Margeret J., Heath, Andrew C., van Duijn, Cornelia M., Bierut, Laura J., Raikkonen, Katri, Martin, Nicholas G., Ciullo, Marina, Rujescu, Dan, Boomsma, Dorret I., Deary, Ian J., Luciano, Michelle, Lopez, Lorna M., de Moor, Marleen H.M., Harris, Sarah E., Davies, Gail, Nutile, Teresa, Krueger, Robert F., Esko, Tõnu, Schlessinger, David, Toshiko, Tanaka, Derringer, Jaime L., Realo, Anu, Hansell, Narelle K., Pergadia, Michele L., Pesonen, Anu-Katriina, Sanna, Serena, Terracciano, Antonio, Madden, Pamela A.F., Penninx, Brenda, Spinhoven, Philip, Hartman, Catherina A., Oostra, Ben A., Janssens, A. Cecile J.W., Eriksson, Johan G., Starr, John M., Cannas, Alessandra, Ferrucci, Luigi, Metspalu, Andres, Wright, Margeret J., Heath, Andrew C., van Duijn, Cornelia M., Bierut, Laura J., Raikkonen, Katri, Martin, Nicholas G., Ciullo, Marina, Rujescu, Dan, Boomsma, Dorret I., and Deary, Ian J.

Abstract

Human longevity and personality traits are both heritable and are consistently linked at the phenotypic level. We test the hypothesis that candidate genes influencing longevity in lower organisms are associated with variance in the five major dimensions of human personality (measured by the NEO-FFI and IPIP inventories) plus related mood states of anxiety and depression. Seventy single nucleotide polymorphisms (SNPs) in six brain expressed, longevity candidate genes (AFG3L2, FRAP1, MAT1A, MAT2A, SYNJ1 and SYNJ2) were typed in over one thousand 70-year old participants from the Lothian Birth Cohort of 1936 (LBC1936). No SNPs were associated with the personality and psychological distress traits at a Bonferroni corrected level of significance (p < 0.0002), but there was an over-representation of nominally significant (p < 0.05) SNPs in the synaptojanin-2 (SYNJ2) gene associated with agreeableness and symptoms of depression. Eight SNPs which showed nominally significant association across personality measurement instruments were tested in an extremely large replication sample of 17 106 participants. SNP rs350292, in SYNJ2, was significant: the minor allele was associated with an average decrease in NEO agreeableness scale scores of 0.25 points, and 0.67 points in the restricted analysis of elderly cohorts (most aged > 60 years). Because we selected a specific set of longevity genes based on functional genomics findings, further research on other longevity gene candidates is warranted to discover whether they are relevant candidates for personality and psychological distress traits.

Published
2011

11. Longevity candidate genes and their association with personality traits in the elderly

Author

Luciano, Michelle, primary, Lopez, Lorna M., additional, de Moor, Marleen H.M., additional, Harris, Sarah E., additional, Davies, Gail, additional, Nutile, Teresa, additional, Krueger, Robert F., additional, Esko, Tõnu, additional, Schlessinger, David, additional, Toshiko, Tanaka, additional, Derringer, Jaime L., additional, Realo, Anu, additional, Hansell, Narelle K., additional, Pergadia, Michele L., additional, Pesonen, Anu‐Katriina, additional, Sanna, Serena, additional, Terracciano, Antonio, additional, Madden, Pamela A.F., additional, Penninx, Brenda, additional, Spinhoven, Philip, additional, Hartman, Catherina A., additional, Oostra, Ben A., additional, Janssens, A. Cecile J.W., additional, Eriksson, Johan G., additional, Starr, John M., additional, Cannas, Alessandra, additional, Ferrucci, Luigi, additional, Metspalu, Andres, additional, Wright, Margeret J., additional, Heath, Andrew C., additional, van Duijn, Cornelia M., additional, Bierut, Laura J., additional, Raikkonen, Katri, additional, Martin, Nicholas G., additional, Ciullo, Marina, additional, Rujescu, Dan, additional, Boomsma, Dorret I., additional, and Deary, Ian J., additional

Published
2011
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