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3. Incobotulinum toxin A in Parkinson's disease with foot dystonia: A double blind randomized trial

Author

Rieu, Isabelle, Degos, Bertrand, Castelnovo, Giovanni, Vial, Christophe, Durand, Elodie, Pereira, Bruno, Simonetta-Moreau, Marion, Sangla, Sophie, Fluchère, Frédérique, Guehl, Dominique, Burbaud, Pierre, Geny, Christian, Gayraud, Dominique, Ory-Magne, Fabienne, Bouhour, Françoise, Llinares, Elisabeth, Derost, Philippe, Marques, Ana, and Durif, Franck

Published
2018
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9. The French version of the Gilles de la Tourette Syndrome Quality of Life Scale for adolescents (GTS-QOL-French-Ado): Adaptation and psychometric evaluation

Author

Jalenques, Isabelle, Guiguet-Auclair, Candy, Cyrille, Diane, Debosque, Clement, Derost, Philippe, Hartmann, Andreas, Lauron, Sophie, Jameux, Clara, Tauveron-Jalenques, Urbain, Rondepierre, Fabien, Service de Psychiatrie de l'Adulte A [CHU Clermont-Ferrand], CHU Clermont-Ferrand, Institut Pascal (IP), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), Service de Neurologie [CHU Clermont-Ferrand], CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand-CHU Estaing [Clermont-Ferrand], Université Clermont Auvergne (UCA), CHU Pitié-Salpêtrière [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

Subjects
Multidisciplinary, Adolescent, Psychometrics, diagnosis, Acclimatization, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Child Humans, Quality of Life, Humans, Reproducibility of Results, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Child, Tourette Syndrome
Abstract

Introduction The aim of this study was to create a new version of the French GTS-QOL adapted to adolescents with GTS aged 12–16 years (GTS-QOL-French-Ado) and to evaluate its psychometric properties. Methods We assessed the psychometric properties of the GTS-QOL-French-Ado in 84 adolescents (mean age 13.6 years, standard deviation 1.2) in terms of factor structure, internal consistency, reliability and convergent validity with the Child Depression Inventory (CDI), the Multidimensional Anxiety Scale for Children (MASC), the Motor tic, Obsessions and compulsions, Vocal tic Evaluation Survey (MOVES) and the French “Vécu et Santé Perçue de l’Adolescent” (VSP-A), a generic self-administered measure of health-related quality of life (HRQoL) in adolescents. Results Exploratory factor analysis of the GTS-QOL-French-Ado resulted in a 5-factor solution. The GTS-QOL-French-Ado demonstrated good acceptability with missing values per subscale ranging from 0% to 1.2%, good internal consistency for four of the five subscales with Cronbach’s alpha ranging from 0.56 to 0.87 and good test–retest reliability with intraclass correlation coefficients ranging from 0.74 (95% CI: 0.52–0.86) to 0.82 (95% CI: 0.66–0.91). Convergent validity was supported by correlations with CDI, MASC, MOVES, VSP-A and clinical variables. Discussion The GTS-QOL-French-Ado is the first disease-specific HRQoL tool for French-speaking adolescents with GTS aged 12–16 years, and shows good psychometric properties. Further psychometric testing on responsiveness to change would be of great interest.

Published
2022

13. Body weight gain and deep brain stimulation

Author

Rieu, Isabelle, Derost, Philippe, Ulla, Miguel, Marques, Ana, Debilly, Bérangère, De Chazeron, Ingrid, Chéreau, Isabelle, Lemaire, Jean Jacques, Boirie, Yves, Llorca, Pierre Michel, and Durif, Franck

Published
2011
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15. Clinical and genetic characteristics of late-onset Huntington's disease

Author

Oosterloo, Mayke, Bijlsma, Emilia K., van Kuijk, Sander MJ., Minkels, Floor, de Die-Smulders, Christine EM., Bachoud-Lévi, Anne-Catherine, Bentivoglio, Anna-Rita, Biunno, Ida, Bonelli, Raphael M., Bronzova, Juliana, Burgunder, Jean-Marc, Dunnett, Stephen B., Ferreira, Joaquim J., Frich, Jan, Giuliano, Joe, Handley, Olivia J., Heiberg, Arvid, Illarioshkin, Sergey, Illmann, Torsten, Klempir, Jiri, Landwehrmeyer, G. Bernhard, Levey, Jamie, Mclean, Tim, Nielsen, Jørgen E., Koivisto, Susana Pro, Päivärinta, Markku, Pålhagen, Sven, Quarrell, Oliver, Ramos-Arroyo, Maria, Roos, Raymund A. C., Saft, Carsten, Sebastián, Ana Rojo, Tabrizi, Sarah J., Vandenberghe, Wim, Verellen-Dumoulin, Christine, Uhrova, Tereza, Wahlström+, Jan, Zaremba, Jacek (formerly Rödig, Verena, Baake, Barth, Katrin, Garde, Monica Bascuñana, Becanovic, Kristina, Bernard, Tomáš, Betz, Sabrina, Bos, Reineke, Come, Adrien, Guedes, Leonor Correia, Callaghan, Jenny, Capodarca, Selene, Charpentier, Sébastien, Vieira da Silva, Wildson, Di Renzo, Martina, Ecker, Daniel, Finisterra, Ana Maria, Fullam, Ruth, Genoves, Camille, Gilling, Mette, Horta, Andrea, Hvalstedt, Carina, Held, Christine, Hussain, Hasina, Koppers, Kerstin, Lamanna, Claudia, Laurà, Matilde, Descals, Asunción Martínez, Martinez-Horta, Saul, Mestre, Tiago, Minster, Sara, Monza, Daniela, Münkel, Kristina, Mütze, Lisanne, Oehmen, Martin, Padieu, Helene, Paterski, Laurent, Peppa, Nadia, Rindal, Beate, Rogers, Dawn, Røren (formerly Heinonen), Niini, Salgueiro, Ana, Šašinková, Pavla, Seliverstov, Yury, Taylor, Catherine, Timewell, Erika, Townhill, Jenny, Cubillo, Patricia Trigo, van Walsem, Marleen R., Witjes-Ané, Marie-Noelle, Witkowski, Grzegorz, Wright, Abigail, Yudina, Elizaveta, Zielonka, Daniel, Zielonka, Eugeniusz, Zinzi, Paola, Hecht, Karen, Herranhof, Brigitte, Holl (formerly Hödl), Anna, Kapfhammer, Hans-Peter, Koppitz, Michael, Lilek, Sabine, Magnet, Markus, Müller, Nicole, Otti, Daniela, Painold, Annamaria, Reisinger, Karin, Scheibl, Monika, Schöggl, Helmut, Ullah, Jasmin, Braunwarth, Eva-Maria, Brugger, Florian, Buratti, Lisa, Hametner, Eva-Maria, Hepperger, Caroline, Holas, Christiane, Hotter, Anna, Hussl, Anna, Larcher, Barbara, Mahlknecht, Philipp, Müller, Christoph, Pinter, Bernadette, Poewe, Werner, Reiter, Eva-Magdalena, Seppi, Klaus, Sprenger, Fabienne, Wenning, Gregor, Ladurner, Gunther, Lilek, Stefan, Sinadinosa, Daniela, Staffen, Wolfgang, Walleczek, Anna Maria, Linder, Christoph, Pirker, Walter, Liessens, Dirk, Calmeyn, Godelinde, Somers, Nele, Delvaux, Isabelle, Boogaerts, Andrea, Flamez, Anja, de Raedt, Sylvie, Alaerts, Nick, Slama, Hichem, Supiot, Frédéric, Constant, Eric, Gillardin, Anne-Françoise, Léonard, Marie-Claude, van de Wyngaerde, Françoise, Dupuis, Michel, Minet, Cécile, Ribaï, Pascale, Van Paemel, Dominique, van Reijen, Dimphna, Weckx, Petra, Kaiserova, Michaela, Šenkárová, Zuzana, Bezdíček, Ondřej, Klempíř, Jiří, Klempířová, Olga, Majerová-Ibarburu, Veronika, Nikolai, Tomáš, Roth, Jan, Stárková, Irena, Madsen, Louise Hasselstrøm, Møller, Anette Torvin, Hjermind, Lena, Jacobsen, Oda, Larsen, Ida Unmack, Lindquist, Suzanne, Nielsen, Jørgen, Regeur, Lisbeth, Roos, Peter, Stockholm, Jette, Vangsted-Hansen, Christina, Vinther-Jensen, Tua, Lolk, Annette, Lundsgaard, Marianne, Wermuth, Lene, Andersson, Christian, Nyberg, Clara, Sundblom, Jimmy, Peippo, Maarit, Sipponen, Marjatta, Bruun, Anu, Hartikainen, Paivi, Mäkipää, Seija, Ollokainen, Mari, Åman, Jaana, Kärppä, Mikko, Ignatius, Jaakko, Jääskeläinen, Outi, Kajula, Outi, Moilanen, Jukka, Mustonen, Aki, Santala, Maire, Eklund, Pia, Hiivola, Heli, Hyppönen, Hannele, Martikainen, Kirsti, Ojala, Marjut, Tähkäpää, Sirkku, Tuuha, Katri, Allain, Philippe, Bonneau, Dominique, Bost, Marie, Gohier, Bénédicte, Guérid, Marie-Anne, Olivier, Audrey, Prouzet, Julie, Prundean, Adriana, Scherer-Gagou, Clarisse, Verny, Christophe, Babiloni, Blandine, Bled, Déborah, Debruxelles, Sabrina, Duché, Charlotte, Fraisse, Sonia, Goizet, Cyril, Jameau, Laetitia, Lafoucrière, Danielle, Spampinato, Umberto, Couttier, Julien, Debilly, Bérengère, Delaigue, Christine, Derost, Philippe, Durif, Franck, Germain, Véronique, Legendre, Perrine, Loiseau, Sylvie, Marques, Ana, Ulla, Miguel, Vidal, Tiphaine, Badei, Farideh, Boissé, Marie-Françoise, Boudali, Lotfi, Cleret de Langavant, Laurent, Lemoine, Laurie, Morgado, Graca, Youssov, Katia, Annic, Agnès, Barthélémy, Recka, De Bruycker, Christelle, Cabaret, Maryline, Carette, Anne-Sophie, Carrière, Nicolas, Decorte, Eric, Defebvre, Luc, Delliaux, Marie, Delval, Arnaud, Depelchin, Alizé, Destee, Alain, Dewulf-Pasz, Nelly, Dondaine, Thibaut, Dugauquier, Florence, Dujardin, Kathy, Hopes, Lucie, Krystkowiak, Pierre, Lemaire, Marie-Hélène, Manouvrier, Sylvie, Mutez, Eugénie, Peter, Mireille, Plomhause, Lucie, Sablonnière, Bernard, Simonin, Clémence, Tard, Céline, Thibault-Tanchou, Stéphanie, Vuillaume, Isabelle, Bellonet, Marcellin, Blin, Stéphanie, Chen, Simone, Masmoudi, Kamel, Morin, Gilles, Roussel, Martine, Tir, Mélissa, Schüler, Béatrice, Wannepain, Sandrine, Zouitina, Yassine, Azulay, Jean-Philippe, Delfini, Marie, Eusebio, Alexandre, Fluchere, Frédérique, Guenam, Aicha, Mundler, Laura, Nguyen, Karine, Benaich, Sandra, Brice, Alexis, Boster, Sarah, Charles, Perrine, Durr, Alexandra, Ewenczyk, Claire, Francisque, Hélène, Jauffret, Céline, Justo, Damian, Kassar, Abdulrahman, Klebe, Stephan, Lesne, Fabien, Milani, Paolo, Monin, Marie-Lorraine, Monnier, Tiffany, Roze, Emmanuel, Tataru, Alina, Tchikviladzé, Maya, Bioux, Sandrine, Bliaux, Evangeline, Girard, Carole, Guyant-Maréchal, Lucie, Hannequin, Didier, Hannier, Véronique, Jourdain, Séverine, Maltête, David, Pouliquen, Dorothée, Anheim, Mathieu, Barun, Nadia, Lagha-Boukbiza, Ouhaid, Longato, Nadine, Marcel, Christophe, Phillipps, Clélie, Rudolf, Gabrielle, Steinmetz, Gisèle, Tranchant, Christine, Wagner, Caroline, Zimmermann, Marie-Agathe, Blondeau, Leily, Calvas, Fabienne, Cheriet, Samia, Delabaere, Helène, Demonet, Jean-François, Marquine, Laurent, Pariente, Jérémie, Pierre, Michèle, Pomies, Elsa, Rolland, Sandrine, Souyris, Corinne, Kosinski, Christoph Michael, Milkereit, Eva, Probst, Daniela, Reetz, Kathrin, Sass, Christian, Schiefer, Johannes, Schlangen, Christiane, Werner, Cornelius J., Beuth, Markus, Gelderblom, Harald, Priller, Josef, Prüß, Harald, Spruth, Eike, Thiel, Silvia, Andrich, Jürgen, Ellrichmann, Gisa, Herrmann, Lennard, Hoffmann, Rainer, Kaminski, Barbara, Kraus, Peter, Stamm, Christiane, Ganos, Christos, Stubbe, Lars, Tadic, Vera, Tübing, Jennifer, Lange, Herwig, Bosredon, Cecile, Hunger, Ulrike, Löhle, Matthias, Maass, Antonia, Ossig, Christiana, Schmidt, Simone, Storch, Alexander, Wolz, Annett, Wolz, Martin, Kohl, Zacharias, Kozay, Christina, Winkler, Jürgen, Bergmann, Ulrike, Böringer, Regina, Capetian, Philipp, Kammel, Gerit, Lambeck, Johann, Mächtel, Miriam, Meier, Simone, Rijntjes, Michel, Zucker, Birgit, Boelmans, Kai, Goerendt, Ines, Heinicke, Walburgis, Hidding, Ute, Lewerenz, Jan, Münchau, Alexander, Orth, Michael, Schmalfeld, Jenny, Zittel, Simone, Diercks, Gabriele, Dressler, Dirk, Francis, Flverly, Gayde-Stephan, Sabine, Gorzolla, Heike, Kramer, Bianca, Minschke, Rebecca, Schrader, Christoph, Tacik, Pawel, Ribbat+, Michael, Longinus, Bernhard, Möller, Carsten, Bürk, Katrin, Lüsebrink, Antje, Mühlau, Mark, Peinemann, Alexander, Städtler, Michael, Weindl, Adolf, Winkelmann, Juliane, Ziegler, Cornelia, Bechtel, Natalie, Beckmann, Heike, Bohlen, Stefan, Göpfert, Nicole, Hölzner, Eva, Reilmann, Ralf, Rohm, Stefanie, Rumpf, Silke, Schepers, Sigrun, Weber, Nathalia, Bachmeier, Michael, Dose, Matthias, Hofstetter, Nina, Marquard, Ralf, Mühlbäck, Alzbeta, Buck, Andrea, Connemann, Julia, Geitner, Carolin, Kesse, Andrea, Landwehrmeyer, Bernhard, Lezius, Franziska, Nepper, Solveig, Niess, Anke, Schneider, Ariane, Schwenk, Daniela, Süssmuth, Sigurd, Trautmann, Sonja, Vogel, Melanie, Weydt, Patrick, Musacchio, Thomas, Leypold, Christine, Nöth, Kerstin, Cormio, Claudia, Difruscolo, Olimpia, Franco, Giovanni, Nuzzi, Angela, Sciruicchio, Vittorio, Serpino, Claudia, de Tommaso, Marina, Calandra-Buonaura, Giovanna, Capellari, Sabina, Cortelli, Pietro, Gallassi, Roberto, Poda, Roberto, Scaglione, Cesa, Agosti, Chiara, Barlati, Sergio, Compostella, Silvia, Marchina, Eleonora, Padovani, Alessando, Figorilli, Michela, Marrosu, Francesco, Muroni, Antonella, Piras, Valeria, Vacca, Melisa, Bertini, Elisabetta, Bartoli, Caterina, Fortunato, Fernanda, Ghelli, Elena, Ginestroni, Andrea, Mechi, Claudia, Paganini, Marco, Piacentini, Silvia, Pradella, Silvia, Romoli, Anna Maria, Sorbi, Sandro, Abbruzzese, Giovanni, Bandettini di Poggio, Monica, Ferrandes, Giovanna, Mandich, Paola, Marchese, Roberta, Di Maria, Emilio, Tamburini, Tiziano, Albanese, Alberto, Castagliuolo, Simona, Castaldo, Anna, Di Donato, Stefano, Di Bella, Daniela, Gellera, Cinzia, Genitrini, Silvia, Mariotti, Caterina, Nanetti, Lorenzo, Panzeri, Marta, Paridi, Dominga, Soliveri, Paola, Spagnolo, Francesca, Taroni, Franco, Tomasello, Chiara, De Michele, Giuseppe, Di Maio, Luigi, Rinaldi, Carlo, Massarelli, Marco, Peluso, Silvio, Roca, Alessandro, Russo, Cinzia Valeria, Salvatore, Elena, Sorrentino, Pierpaolo, Tucci, Tecla, Cannella, Milena, Codella, Valentina, De Gregorio, Francesca, De Nicola, Annunziata, Elifani, Francesca, Esposito, Chiara, Martino, Tiziana, Mazzante, Irene, Petrollini, Martina, Simonelli, Maria, Vezza, Maurizio, Squitieri, Ferdinando, D'Alessio, Barbara, Lovo, Francesca, Bentivoglio, Anna Rita, Bove, Francesco, Catalli, Claudio, Di Giacopo, Raffaella, Fasano, Alfonso, Frontali, Marina, Guidubaldi, Arianna, Ialongo, Tamara, Jacopini, Gioia, Loria, Giovanna, Modoni, Anna, Petracca, Martina, Piano, Carla, Chiara, Piccininni, Quaranta, Davide, Romano, Silvia, Soleti, Francesco, Solito, Marcella, Spadaro, Maria, Torlizzi, Flavia, Coarelli, Giulia, Ferraldeschi, Michela, Ristori, Giovanni, van Hout, Monique S. E., van Vugt, Jeroen P. P., Marit de Weert, A., Verhoeven, Marloes, Dekker, Meike, Klooster, Jesper, Leenders, Nico, van Oostrom, Joost, Kremer, Berry, Baake, Verena, van den Bogaard, Simon J. A., Dumas, Eve M., t Hart, Ellen P., Hogenboom, Marye, Jacobs, Milou, Jurgens, Caroline, Kampstra, Anne, Schoonderbeek, Anne, Witjes-Ané, Marie-Noëlle, Duits, Annelien, Waber, Mirella, Verstappen, Carla, Blinkenberg, Ellen Økland, Hauge, Erik, Tyvoll, Hilde, Aaserud, Olaf, Aanonsen, Nils Olaf, Bjørgo, Kathrine, Borgerød, Nancy, Dramstad, Elisabeth, Fannemel, Madeleine, Frich, Jan C., Gørvell, Per F., Haggag, Kathrine, Johannessen, Cecilie Haggag, Retterstøl, Lars, Røsby, Oddveig, Rummel, Jutta, Sikiric, Alma, Stokke, Bodil, van Walsem, Marleen, Wehus, Ragnhild, Arntsen, Vibeke, Bjørnevoll, Inga, Sando, Sigrid Botne, Haug, Marte Gjøl, Størseth, Hanna Haugan, Østern, Rune, Paulsen, Julie, Dziadkiewicz, Artur, Konkel, Agnieszka, Narożańska, Ewa, Nowak, Malgorzata, Robowski, Piotr, Sitek, Emilia, Slawek, Jaroslaw, Soltan, Witold, Szinwelski, Michal, Arkuszewski, Michał, Błaszczyk, Magdalena, Boczarska-Jedynak, Magdalena, Ciach-Wysocka, Ewelina, Gorzkowska, Agnieszka, Jasińska-Myga, Barbara, Kaczmarczyk, Aleksandra, Kłodowska – Duda, Gabriela, Opala, Grzegorz, Rudzińska, Monika, Stompel, Daniel, Banaszkiewicz, Krzysztof, Boćwińska, Dorota, Bojakowska-Jaremek, Kamila, Dec, Małgorzata, Grabska, Natalia, Krawczyk, Malgorzata, Kubowicz, Ewelina, Malec-Litwinowicz, Michalina, Stenwak, Agata, Szczudlik, Andrzej, Szczygieł, Elżbieta, Wójcik, Magdalena, Wasielewska, Anna, Anna Bryl, Jacek Anioła, Ciesielska, Anna, Klimberg, Aneta, Marcinkowski, Jerzy, Samara, Husam, Sempołowicz, Justyna, Wiśniewski, Bartłomiej, Gogol (formerly Kalbarczyk), Anna, Janik, Piotr, Jamrozik, Zygmunt, Kaminska, Anna, Kwiecinski+, Hubert, Antczak, Jakub, Jachinska, Katarzyna, Krysa, Wioletta, Rakowicz, Maryla, Rola, Rafal, Ryglewicz, Danuta, Sienkiewicz-Jarosz, Halina, Stępniak, Iwona, Sułek, Anna, Zaremba, Jacek, Zdzienicka, Elzbieta, Ziora-Jakutowicz, Karolina, Januário, Cristina, Júlio, Filipa, Almeida, Manuel, Calado, Ana, Dias, Margarida, Morgado, Joana, Semedo, Cristina, Coelho, Miguel, Magalhães, Andreia, Mendes, Tiago, Neutel, Dulce, Rodrigues, Filipe, Valadas, Anabela, Costa, Cristina, Cardoso, Helena, Santos, Mariana, Cação, Gonçalo, Cavaco, Sara, Damásio, Joana, Fernandes, Joana, Gonçalves, Alexandra, Loureiro, Rui, Moreira, Inês, Magalhães, Marina, Salgado, Paula, Andrade, Carlos, Costa, Andreia, Garrett, Carolina, Gago, Miguel, Guimarães, Joana, Massano, João, Meireles, Joana, Monteiro, Ana, Khasanova, Diana, Zalyalova, Zuleykha, Klyushnikov, Sergey, Sidorova, Olga, Smirnov, Oleg, Antonova, Victoria, Kopishinskaya, Svetlana, Korotysh, Maria, Magzhanov, Rim, Saifullina, Elena, Kurbatov, Sergey, Solis, Pilar, Herrera, Carmen Durán, Moreno, Patrocinio Garcia, Bas, Jordi, Busquets, Núria, Calopa, Matilde, Classen, Serge Jaumà, Dedichá, Nadia Rodríguez, Buongiorno, María Teresa, María, Andrés de la Cerda Santa, Muñoz, Esteban, Santacruz, Pilar, Barbera, Miquel Aguilar, Pardo, Sonia Arribas, Guia, Dolors Badenes, Calzado, Noemi, Hernanz, Laura Casas, Tartari Díaz-Zorita, Juan Pablo, Catena, Judit López, Ferrer, Pilar Quiléz, Carruesco, Gemma Tome, Robert, Misericordia Floriach, Viladrich, Cèlia Mareca, Roca, Elvira, Ruiz Idiago, Jesús Miguel, Riballo, Antonio Villa, Campolongo, Antonia, Fernandez de Bobadilla, Ramon, Bojarsky, Jaime Kulisevsky, Pagonabarraga, Javier, Perez, Jesus Perez, Ribosa, Roser, Villa, Carolina, Acera Gil, Maria Angeles, Corrales, Koldo Berganzo, Gomez Esteban, Juan Carlos, González, Amaia, Merino, Beatriz Tijero, Cubo, Esther, Polo, Cecilia Gil, Mariscal, Natividad, Sánchez, Jesús, Romero, Sandra Gutierrez, Arbelo, José Matías, Malo de Molina, Rocío, Martín, Idaira, Periañez, Juan Manuel, Udaeta, Beatriz, Alonso-Frech, Fernando, Loarte, María del Valle, Barrero, Francisco, Morales, Blas, Frades, Belén, Villanueva, Marina Ávila, Zea Sevilla, Maria Ascension, Fenollar, María del Mar, García-Ramos García, Rocío, Villanueva, Clara, Bascuñana, Mónica, Ventura, Marta Fatás, Caldentey, Juan García, Ribas, Guillermo García, García de Yébenes, Justo, López-Sendón Moreno, José Luis, Barral, Verónica Mañanes, Feliz, Cici, García Ruíz, Pedro José, García, Ana, López, Rosa Guerrero, Bárcenas, Antonio Herranz, Martínez-Descals, Asunción, Pueyo, Angel Martínez, Martin, Veronica Puertas, Martínez, Noelia Rodríguez, Montojo, Teresa, Sainz Artiga, María José, Sánchez, Vicenta, Alarcón, María Dolores, Almagro, Carmen Antúnez, Diéguez, Esther, Fortuna, Lorenza, Legaz, Agustina, Manzanares, Salvadora, Muñoz, Juan Marín, Antequera Torres, María Martirio, Perea, Fuensanta Noguera, Vivancos, Laura, González, Sonia, Guisasola, Luis Menéndez, Prieto, Marta Para, Ribacoba, René, Salvador, Carlos, Lozano, Pablo Sánchez, Ramirez, Inés Legarda, Benito, Dolors Moragues, Arques, Penelope Navas, Lopera, Monica Rodriguez, Pastor, Barbara Vives, Gaston, Itziar, Garcia-Amigot, Fermin, Martinez-Jaurrieta, Maria Dolores, Ramos-Arroyo, Maria Antonia, Adarmes, Astrid, Bernal-Escudero, Maravilla, Carrillo, Fátima, Jesús, Silvia, Mir, Pablo, Vargas-González, Laura, Hermoso, Fátima Damas, García Moreno, José Manuel, Jaramillo, Javier Abril, Lucena, Carolina Mendez, Pacheco Cortegana, Eva María, Peña, José Chacón, Redondo, Luis, Sánchez, Violeta Sánchez, Fernandez, Cristina Melgar, Romero Lemos, María Dolores, Mata, Maite Paredes, Casado, Rocío Villagrán, Bosca, Maria, Burguera, Juan Andres, Brugada, Francisco Castera, Millán Salvador, Jose Maria, Vilaplana, Carmen Peiró, Solís, Pilar, Figuerola, Begoña Jeweinat, Palanca, Paloma Millan, Diago, Elena Bellosta, López del Val, Javier, Martinez, Laura Martinez, López, Elena, Høsterey-Ugander, Ulrika, Fredlund, Gunnel, Constantinescu, Radu, Lewin, Kajsa, Neleborn-Lingefjärd, Liselotte, Berglund, Maria, Berglund, Peter, Linnsand, Petra, Petersén, Åsa, Reimer, Jan, Widner, Håkan, Esmaeilzadeh, Mouna, Tedroff, Joakim, Winnberg, Elisabeth, Benaminov, Stanislav, Björnsson, Elisabeth, Merrick, Daniel, Paucar, Martin, Svenningsson, Per, Wallden, Tina, Berglund, Måns, Loutfi, Ghada, Olofsson, Carina, Stattin, Eva-Lena, Westman, Laila, Wikström, Birgitta, Ekwall, Camilla, Göller, Marie-Lousie, Johansson, Anders, Niemelä, Valter, Nyholm, Dag, Wiklund, Leif, Koehli, Jessica, Stebler, Yanik, Kaelin, Alain, Romero, Irene, Schüpbach, Michael, Zaugg, Sabine Weber, Esposito, Federica, Good, Jean-Marc, Paus, Karin, Vingerhoets, Francois, Wider+, Christian, Jung, Hans H., Petersen, Jens A., Ligon-Auer, Maria, Mihaylova, Violeta, Downie, Lorna, Jack, Roisin, Matheson, Kirsty, Miedzybrodzka, Zosia, Rae, Daniela, Simpson, Sheila A., Summers, Fiona, Ure, Alexandra, Vaughan, Vivien, Harrower, Timothy, Vernon, Nathan, Akhtar, Shahbana, Crooks, Jenny, Curtis, Adrienne, de Souza (Keylock), Jenny, Piedad, John, Rickards, Hugh, Wright, Jan, Haig-Brown, Diane, Craven, Janet, Pallett, Andrew, Simpson, Steve, Weekes, Rebecca, Coulthard, Elizabeth, Gethin, Louise, Hayward, Beverley, Sieradzan, Kasia, Barker, Roger A., O'Keefe, Deidre, Gerrtiz (nee Di Pietro), Anna, Fisher, Kate, Goodman, Anna, Hill, Susan, Mason, Sarah, Swain, Rachel, Guzman, Natalie Valle, Busse, Monica, Butcher, Cynthia, Dunnett, Stephen, Clenaghan, Catherine, Hunt, Sarah, Jones, Lesley, Jones, Una, Khalil, Hanan, Owen, Michael, Price, Kathleen, Rosser, Anne, Goudie, David, Buchanan, Lindsay, Mcfadyen, Paula, Tonner, Alison, Taylor, Anne-Marie, Edwards, Maureen, Carrie, Ho, Mcgill, Marie, Porteous, Mary, Pearson, Pauline, Irvine, Sarah, Brockie, Peter, Foster, Jillian, Johns, Nicola, Mckenzie, Sue, Rothery, Jean, Thomas, Gareth, Yates, Shona, Neumann, Christian, Patterson, Kirsten, Thomson, David, Deith, Catherine, Ireland, Jane, Ritchie, Stuart, Brown, Pauline, Burrows, Liz, Fletcher, Amy, Harding, Alison, Harrison, Kaye, Laver, Fiona, Silva, Mark, Thomson, Aileen, Chu, Carol, Evans, Carole, Gallentree, Deena, Hamer, Stephanie, Kraus, Alison, Markova, Ivana, Raman, Ashok, Rowett, Liz, Andrew, Alyson, Frost, Julie, Noad, Rupert, Cosgrove, Jeremy, Gallantree, Deena, Hobson, Emma, Jamieson, Stuart, Longthorpe, Mandy, Musgrave, Hannah, Peacy, Caroline, Toscano, Jean, Wild, Sue, Yardumian, Pam, Clayton, Carole, Dipple, Heather, Freire-Patino, Dawn, Hallam, Caroline, Middleton, Julia, Alusi, Sundus, Davies, Rhys, Foy, Kevin, Gerrans, Emily, Pate, Louise, Anjum, Uruj, Coebergh, Jan, Eddy, Charlotte, Lahiri, Nayana, Mcentagart, Meriel, Patton, Michael, Peterson, Maria, Rose, Sarah, Andrews, Thomasin, Dougherty, Andrew, Golding, Charlotte, Kavalier, Fred, Laing, Hana, Lashwood, Alison, Robertson, Dene, Ruddy, Deborah, Santhouse, Alastair, Whaite, Anna, Gosling (nee Brown), Stefanie, Bruno, Stefania, Chu, Elvina, Doherty, Karen, Haider, Salman, Hensman, Davina, Lewis, Monica, Novak, Marianne, Patel, Aakta, Robertson, Nicola, Rosser, Elisabeth, Tabrizi, Sarah, Taylor, Rachel, Warner, Thomas, Wild, Edward, Ackermann, Oda, Duport, Sophie, Scott, Adrienne, Stoy, Nicholas, Vaughn, Jenny, Arran, Natalie, Bek, Judith, Craufurd, David, Hare, Marianne, Howard, Liz, Huson, Susan, Johnson, Liz, Jones, Mary, Krishnamoorthy, Ashok, Murphy, Helen, Oughton, Emma, Partington-Jones, Lucy, Sollom, Andrea, Snowden, Julie, Stopford, Cheryl, Thompson, Jennifer, Trender-Gerhard, Iris, Verstraelen (formerly Ritchie), Nichola, Westmoreland, Leann, Cass, Ginette, Davidson, Lynn, Davison, Jill, Fullerton, Neil, Holmes, Katrina, Komati, Suresh, Mcdonnell, Sharon, Mohammed, Zeid, Morgan, Karen, Savage, Lois, Singh, Baldev, Wood, Josh, Knight, Caroline, O'Neill, Mari, Purkayastha, Debasish Das, Nemeth, Andrea H., Siuda, Gill, Valentine, Ruth, Dixon, Kathryn, Armstrong, Richard, Harrison, David, Hughes, Max, Large, Sandra, Donovan, John O., Palmer, Amy, Parkinson, Andrew, Soltysiak, Beverley, Timings, Leanne, Williams, Josh, Burn, John, Bailey, Wendy, Coleman, Caroline, Majeed, Tahir, Verstraelen (Ritchie), Nicola, Barrett, Wendy, Aileen, Ho, Bandmann, Oliver, Bradbury, Alyson, Fairtlough, Helen, Fillingham, Kay, Foustanos, Isabella, Gill, Paul, Kazoka, Mbombe, O'Donovan, Kirsty, Nevitt, Louise, Taylor, Cat, Tidswell, Katherine, Kipps, Christopher, Mackinnon, Lesley, Agarwal, Veena, Hayward, Elaine, Gunner, Kerry, Harris, Kayla, Anderson, Mary, Heywood, Melanie, Keys, Liane, Smalley, Sarah, El-Nimr, George, Duffell, Allison, Wood, Sue, Kennedy (nee Smith), Karen, Gowers, Lesley, Powell, Kingsley, Bethwaite, Pamela, Edwards, Rachel, Fuller, Kathleen, Phillips, Michelle, Tan, Louis, Lau, Puay Ngoh, Pica, Emmanuel, Roos, Raymund AC., Klinische Neurowetenschappen, MUMC+: MA Med Staf Spec Neurologie (9), MUMC+: KIO Kemta (9), Epidemiologie, RS: CAPHRI - R2 - Creating Value-Based Health Care, Klinische Genetica, MUMC+: DA KG Polikliniek (9), and RS: GROW - R4 - Reproductive and Perinatal Medicine

Subjects
Male, HD, 0301 basic medicine, Pediatrics, Neurology, Huntingtin Protein/genetics, FEATURES, Disease, Neuropsychological Tests, 0302 clinical medicine, Cognitive Dysfunction/psychology, Medicine, Family history, Postural Balance, Huntington Disease/genetics, Huntingtin Protein, education.field_of_study, Chorea/physiopathology, Huntington's disease, Sensation Disorders/physiopathology, Middle Aged, Dystonia, Settore MED/26 - NEUROLOGIA, Huntington Disease, neurodegenerative disorders, Sensation Disorders, Disease Progression, Female, medicine.symptom, Adult, medicine.medical_specialty, Population, Age of onset, Late-onset Huntington's disease, Geriatrics and Gerontology, Neurology (clinical), 03 medical and health sciences, AGE, Chorea, Humans, Cognitive Dysfunction, education, Dystonia/physiopathology, Gait Disorders, Neurologic/physiopathology, Gait Disorders, Neurologic, business.industry, medicine.disease, Gait, 030104 developmental biology, Trinucleotide Repeat Expansion, business, 030217 neurology & neurosurgery, Balance problems
Abstract

Background: The frequency of late-onset Huntington's disease (>59 years) is assumed to be low and the clinical course milder. However, previous literature on late-onset disease is scarce and inconclusive. Objective: Our aim is to study clinical characteristics of late-onset compared to common-onset HD patients in a large cohort of HD patients from the Registry database. Methods: Participants with late- and common-onset (30–50 years)were compared for first clinical symptoms, disease progression, CAG repeat size and family history. Participants with a missing CAG repeat size, a repeat size of ≤35 or a UHDRS motor score of ≤5 were excluded. Results: Of 6007 eligible participants, 687 had late-onset (11.4%) and 3216 (53.5%) common-onset HD. Late-onset (n = 577) had significantly more gait and balance problems as first symptom compared to common-onset (n = 2408) (P

Published
2019

19. Subthalamic nucleus stimulation in severe obsessive-compulsive disorder

Author

Mallet, Luc, Polosan, Mircea, Jaafari, Nemotollah, Baup, Nicolas, Welter, Marie-Laure, Fontaine, Denys, du Montcel, Sophie Tezenas, Yelnik, Jerome, Chereau, Isabelle, Arbus, Christophe, Raoul, Sylvie, Aouizerate, Bruno, Damier, Philippe, Chabardes, Stephan, Czernecki, Virginie, Ardouin, Claire, Krebs, Marie-Odile, Bardinet, Eric, Chaynes, Patrick, Burbaud, Pierre, Cornu, Philippe, Derost, Philippe, Bougerol, Thierry, Bataille, Benoit, Mattei, Vianney, Dormont, Didier, Devaux, Bertrand, Verin, Marc, Houeto, Jean-Luc, Pollak, Pierre, Benabid, Alim-Louis, Agid, Yves, Krack, Paul, Millet, Bruno, and Pelissolo, Antoine

Subjects
Obsessive-compulsive disorder -- Diagnosis, Obsessive-compulsive disorder -- Care and treatment, Obsessive-compulsive disorder -- Risk factors
Abstract

A study was conducted to evaluate the efficacy of subthalamic nucleus stimulation in reducing the symptoms of severe obsessive-compulsive disorder. Results indicated that subthalamic nucleus stimulation does reduce the symptoms of severe obsessive-compulsive disorder but at the same time poses a risk of serious adverse events.

Published
2008

21. Reducing Attentional Bias in Individuals With Alcohol Use Disorders With a Tablet Application: A Randomized Controlled Trial Pilot Study

Author

Pereira, Bruno, Benchetrit, Eve, Socha, Julie, Pineau, Fanny, Elbaz, Alexis, Artaud, Fanny, Mangone, Graziella, You, Hana, Cormier, Florence, Galitstky, Monique, Pomies, Elsa, Derkinderen, Pascal, Weintraub, Daniel, Corvol, Jean Christophe, Chereau-Boudet, Isabelle, Fantini, Maria Livia, Marques, Ana, Derost, Philippe, Boirie, Yves, Girard, Romuald, Obeso, Ignacio, Thobois, Stéphane, Park, Seongmin, Vidal, Tiphaine, Favre, Emilie, Ulla, Miguel, Broussolle, Emmanuel, Krack, Paul, Dreher, Jean-Claude, Corvol, Jean-Christophe, Durif, Franck, Meissner, Wassilios, Azulay, Jean-Philippe, Haddad, Raphaël, Guimarães-Costa, Raquel, Mariani, Louise-Laure, Cormier-Dequaire, Florence, Thalamas, Claire, Galitzky, Monique, Boraud, Thomas, Debilly, Bérengère, Eusebio, Alexandre, Houot, Marion, Dellapina, Estelle, Chaigneau, Véronique, Salis, Alexandrine, Lacomblez, Lucette, Benel, Laurent, Rascol, Olivier, Flaudias, Valentin, Zerhouni, Oulmann, Chakroun-Baggioni, Nadia, Pires, Sylvie, Schmitt, Audrey, De Chazeron, Ingrid, Llorca, Pierre Michel, Brousse, Georges, Service de Psychiatrie de l'Adulte B [CHU Clermont-Ferrand], CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Laboratoire Parisien de Psychologie Sociale (LAPPS), Université Paris Nanterre (UPN)-Université Paris 8 Vincennes-Saint-Denis (UP8), Laboratoire de Psychologie Sociale et Cognitive (LAPSCO), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), service de Biostatistiques, DRCI, Centre Hospitalier Universitaire de Clermont-Ferrand, Service de neurologie 1 [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [APHP]-Centre National de la Recherche Scientifique (CNRS), Epidemiology, Departments of Health Sciences Research, Mayo Clinic College of Medicine, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [APHP]-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Neuropathies du système nerveux entérique et pathologies digestives, implication des cellules gliales entériques, Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Neurology, University of Pennsylvania [Philadelphia], Centres d'addictologies - Région Centre, CHU Clermont-Ferrand, Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux - Clermont Auvergne (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne (UCA), Service de neurologie, Hôpital Gabriel Montpied, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université, Institut des sciences cognitives Marc Jeannerod - Centre de neuroscience cognitive - UMR5229 (CNC), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Service de Neurologie, Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Service de Neurologie [CHU Clermont-Ferrand], Hospices Civils de Lyon (HCL), Neurosciences précliniques, Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut des Maladies Neurodégénératives [Bordeaux] (IMN), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Hôpital de la Timone [CHU - APHM] (TIMONE), Institut de Myologie, Université Pierre et Marie Curie - Paris 6 (UPMC)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Association française contre les myopathies (AFM-Téléthon)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de neurologie [Le Kremlin Bicêtre], Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Bicêtre, CIC - Biotherapie - Toulouse, Institut National de la Santé et de la Recherche Médicale (INSERM), CIC Toulouse, Laboratoire Mouvement Adaptation Cognition (MAC), Université Bordeaux Segalen - Bordeaux 2-Centre National de la Recherche Scientifique (CNRS), Institut de Neurosciences de la Timone (INT), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Imagerie Biomédicale (LIB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Imagerie cérébrale et handicaps neurologiques, Institut des sciences du cerveau de Toulouse. (ISCT), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UPS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UPS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Inter-universitaire de Psychologie : Personnalité, Cognition, Changement Social (LIP-PC2S ), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Grenoble Alpes (UGA), Laboratoire de Psychologie Sociale et Cognitive - Clermont Auvergne (LAPSCO), Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), and Université Paris 8 Vincennes-Saint-Denis (UP8)-Université Paris Nanterre (UPN)

Subjects
Adult, Male, Cognitive bias modification, Ecological validity, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Mental processes, education, Craving, Pilot Projects, Alcohol use disorder, Attentional bias, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Memory, medicine, Humans, ComputingMilieux_MISCELLANEOUS, Tablet dosage form, [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, Cognitive Behavioral Therapy, Ethanol, business.industry, [SCCO.NEUR]Cognitive science/Neuroscience, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, Play behavior, Cognition, General Medicine, Middle Aged, medicine.disease, Cognitive bias, 030227 psychiatry, Alcoholism, Inhibition, Psychological, Treatment Outcome, Therapy, Computer-Assisted, [SCCO.PSYC]Cognitive science/Psychology, Female, medicine.symptom, business, 030217 neurology & neurosurgery, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Clinical psychology
Abstract

Aims Cognitive bias modification (CBM) training has been considered a promising and effective intervention tool for reducing cognitive biases toward alcohol. However, the link between the cognitive process and actual behavior remains statistically insignificant because computerized tasks do not have sufficient ecological validity and suffer from high dropout rates. The recent development of ‘serious games’ has shown encouraging results in maintaining adherence to health-related interventions. We aim to evaluate a CBM program using a gamified attentional bias (AB) training procedure on a touchpad for individuals with alcohol use disorders. Methods Forty-one patients were included in this study, 33 of whom displayed an AB and were randomly assigned into the ‘CBM group’ (N = 18, 16.7% women) or ‘Memory group’—which involved playing a memory game—(N = 15, no woman). Eight other participants (12.5% women) with no AB comprised the ‘Without AB group’. Efficacy was assessed for AB, craving, and inhibition and attentional capacities before and after the program. Results We observed that the reduction of AB was higher for the ‘CBM group’ (Mbefore = 153.61, SD = 172.21; Mafter = 18.00, SD = 77.71; t (17) = 4.21, P = 0.001) than for the ‘Memory group’ (Mbefore = 73.20, SD = 66.65; Mafter =42.47, SD = 113.77; ts Conclusions This study demonstrated an increased reduction of AB for patients included in the CBM program on a touchpad than for patients playing only a memory game.

Published
2020

22. Bilateral deep brain stimulation of the globus pallidus to treat tardive dyskinesia

Author

Damier, Philippe, Thobois, Stephane, Witjas, Tatiana, Cuny, Emmanuel, Derost, Philippe, Raoul, Sylvie, Mertens, Patrick, Peragut, Jean-Claude, Lemaire, Jean-Jacques, Burbaud, Pierre, Nguyen, Jean-Michel, Llorca, Pierre-Michel, and Rascol, Olivier

Subjects
Movement disorders -- Research, Movement disorders -- Care and treatment, Brain stimulation -- Usage, Brain stimulation -- Health aspects, Brain stimulation -- Research, Brain -- Research, Brain -- Physiological aspects, Health, Psychology and mental health
Published
2007

27. Preoperative REM Sleep Behavior Disorder and Subthalamic Nucleus Deep Brain Stimulation Outcome in Parkinson Disease 1 Year After Surgery.

Author

Besse-Pinot, Elsa, Pereira, Bruno, Durif, Franck, Fantini, Maria Livia, Durand, Elodie, Debilly, Bérengère, Derost, Philippe, Moreau, Caroline, Hainque, Elodie, Rouaud, Tiphaine, Eusebio, Alexandre, Benatru, Isabelle, Drapier, Sophie, Guehl, Dominique, Rascol, Olivier, Maltête, David, Lagha-Boukbiza, Ouhaïd, Giordana, Caroline, Tir, Melissa, and Thobois, Stéphane

Published
2021
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30. OpenSIMPLe: A real-world implementation feasibility study of a smartphone-based psychoeducation programme for bipolar disorder

Author

marques, ana, Figorilli, Michela, Pereira, Bruno, Derost, Philippe, Debilly, Bérengère, Beudin, Patricia, Durif, Franck, Fantini, Maria Livia, Hidalgo-Mazzei, Diego, Reinares, María, Mateu, Ainoa, Nikolova, Viktoriya, Bonnín, Caterina del Mar, Samalin, Ludovic, García-Estela, Aitana, Pérez-Solá, Víctor, Young, Allan, Strejilevich, Sergio, Vieta, Eduard, Colom, Francesc, Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Unité de Biostatistiques [CHU Clermont-Ferrand], Direction de la recherche clinique et de l’innovation [CHU Clermont-Ferrand] (DRCI), CHU Clermont-Ferrand-CHU Clermont-Ferrand, European Network of Bipolar Research Expert Centres (ENBREC), ENBREC, and Universitat de Barcelona

Subjects
Adult, Male, medicine.medical_specialty, Bipolar Disorder, 020205 medical informatics, medicine.medical_treatment, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, 02 engineering and technology, Odds, 03 medical and health sciences, 0302 clinical medicine, Patient Education as Topic, Intervention (counseling), Surveys and Questionnaires, Outcome Assessment, Health Care, 0202 electrical engineering, electronic engineering, information engineering, medicine, Psychoeducation, Humans, Manic-depressive illness, Attrition, Bipolar disorder, Telèfons intel·ligents, ComputingMilieux_MISCELLANEOUS, Internet, Trastorn bipolar, [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, business.industry, [SCCO.NEUR]Cognitive science/Neuroscience, Health Plan Implementation, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, Usability, Middle Aged, medicine.disease, Mental health, 030227 psychiatry, 3. Good health, Psychotherapy, Psychiatry and Mental health, Clinical Psychology, Smartphones, Mental Health, Helpfulness, Family medicine, Feasibility Studies, Female, Smartphone, Psychology, business
Abstract

BACKGROUND: Few evidence-based mental health apps are widely available to patients and, conversely, many of the available apps have not been appropriately evaluated. Given that the ultimate goal is to scale-up and open internet-based platforms (IBP), it is crucial to appropriately evaluate their real-world feasibility beforehand. We aimed to evaluate the implementation feasibility of a smartphone-based psychoeducational programme for bipolar disorder, exploring its long-term retention, usability, perceived helpfulness and satisfaction, alongside its impact on secondary health outcomes.METHODS: Participants were recruited via the project website after completing an online screening questionnaire. They were requested to complete web-based questionnaires before using the app and after 6 months of use which included sociodemographic, illness and treatment variables, the world health organisation-five well-being index (WHO-5) and the short form health survey (SF-36). The follow-up questionnaires also contained satisfaction and usefulness questions.RESULTS: 201 participants took part in the study. According to their retention, 66.2% of the participants were classified as noncompleters and 33.8% as completers. The only predictor significantly associated with higher odds of retention was older age (OR = 1.021, p LIMITATIONS: Screening and outcome measures were administered using exclusively self-reported online methods.CONCLUSION: The 6-month attrition rate of the programme was high. Positive outcomes regarding satisfaction were found predominantly among completers. The optimal dosage and retention of IBP mental health programmes remain challenging issues that need further research.

Published
2018

31. Quality of life in adults with Gilles de la Tourette Syndrome

Author

Jalenques Isabelle, Galland Fabienne, Malet Laurent, Morand Dominique, Legrand Guillaume, Auclair Candy, Hartmann Andreas, Derost Philippe, and Durif Franck

Subjects
Gilles de la Tourette Syndrome, Quality of life, Physical and psychological health status, Psychology, Psychiatric disorders, Depression, Psychiatry, RC435-571
Abstract

Abstract Background Few studies have used standardized QOL instruments to assess the quality of life (QOL) in Gilles de la Tourette Syndrome (GTS) patients. This work investigates the QOL of adult GTS patients and examines the relationships between physical and psychological variables and QOL. Methods Epidemiological investigation by anonymous national postal survey of QOL of patients of the French Association of Gilles de la Tourette Syndrome (AFGTS) aged 16 years or older. The clinical and QOL measures were collected by four questionnaires: a sociodemographic and GTS-related symptoms questionnaire, the World Health Organization Quality Of Life questionnaire (WHOQOL-26), the Functional Status Questionnaire (FSQ), and a self-rating questionnaire on psychiatric symptoms (SCL-90), all validated in French. We used stepwise regression analysis to explicitly investigate the relationships between physical and psychological variables and QOL domains in GTS. Results Questionnaires were posted to 303 patients, of whom 167 (55%) completed and returned them. Our results, adjusted for age and gender, show that patients with GTS have a worse QOL than the general healthy population. In particular, the “Depression” psychological variable was a significant predictor of impairment in all WHOQOL-26 domains, psychological but also physical and social. Conclusions The present study demonstrates a strong relationship between QOL in GTS and psychiatric symptoms, in particular those of depression.

Published
2012
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32. Cross-cultural adaptation and psychometric evaluation of the French version of the Gilles de la Tourette Syndrome Quality of Life Scale (GTS-QOL).

Author

Jalenques, Isabelle, Cyrille, Diane, Derost, Philippe, Hartmann, Andreas, Lauron, Sophie, Jameux, Clara, Tauveron-Jalenques, Urbain, Guiguet-Auclair, Candy, and Rondepierre, Fabien

Subjects
CRONBACH'S alpha, TOURETTE syndrome, PSYCHOMETRICS, MISSING data (Statistics), QUALITY of life, EXPLORATORY factor analysis
Abstract

Introduction: The Gilles de la Tourette Syndrome–Quality of Life Scale (GTS-QOL) is a self-rated disease-specific questionnaire to assess health-related quality of life of subjects with GTS. Our aim was to perform the cross-cultural adaptation of the GTS-QOL into French and to assess its psychometric properties. Methods: The GTS-QOL was cross-culturally adapted by conducting forward and backward translations, following international guidelines. The psychometric properties of the GTS-QOL-French were assessed in 109 participants aged 16 years and above with regard to factor structure, internal consistency, reliability and convergent validity with the MOVES (Motor tic, Obsessions and compulsions, Vocal tic Evaluation Survey) and the WHOQOL-BREF (World Health Organization Quality of Life Brief). Results: Exploratory factor analysis of the GTS-QOL-French resulted in a 6-factor solution and did not replicate the original structure in four subscales. The results showed good acceptability (missing values per subscale ranging from 0% to 0.9%), good internal consistency (Cronbach's alpha ranging from 0.68 to 0.94) and good test–retest reliability (intraclass correlation coefficients ranging from 0.70 to 0.81). Convergent validity with the MOVES and WHOQOL-BREF scales showed high correlations. Discussion: Our study provides evidence of the good psychometric properties of the GTS-QOL-French. The cross-cultural adaptation and validation of this specific instrument will make it possible to assess health-related quality of life in French-speaking subjects with GTS. The GTS-QOL-French could be recommended for use in future research. [ABSTRACT FROM AUTHOR]

Published
2020
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34. Depigmenting effect of argan press-cake extract through the down-regulation of Mitf and melanogenic enzymes expression in B16 murine melanoma cells

Author

Jalenques, Isabelle, Guiguet-Auclair, Candy, Derost, Philippe, Joubert, Pauline, Foures, Louis, Hartmann, Andreas, Muellner, Julia, Rondepierre, Fabien, Ouachikh, Omar, Hafidi, Aziz, Boucher, Yves, Dieb, Wisam, Bourhim, Thouria, Villareal, Myra, Gadhi, Chemseddoha, Hafidi, Abdellatif, Isoda, Hiroko, Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux - Clermont Auvergne (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne (UCA), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Psychiatrie Addictologie, CHU Gabriel Montpied, 63 000 Clermont-Ferrand, Institut de psychiatrie et neurosciences (U894 / UMS 1266), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Descartes - Paris 5 (UPD5), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [APHP]-Centre National de la Recherche Scientifique (CNRS)

Subjects
0301 basic medicine, food.ingredient, Tyrosinase, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Clinical Biochemistry, Biomedical Engineering, Argan oil, Bioengineering, Melanin, 03 medical and health sciences, 0302 clinical medicine, food, Cytotoxicity, ComputingMilieux_MISCELLANEOUS, chemistry.chemical_classification, [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, Cell growth, [SCCO.NEUR]Cognitive science/Neuroscience, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, Cell Biology, Microphthalmia-associated transcription factor, Molecular biology, 030104 developmental biology, Enzyme, chemistry, 030220 oncology & carcinogenesis, Original Article, Dopachrome tautomerase, Biotechnology
Abstract

Oil extraction from the kernels of Argania spinosa (L.) Skeels (Sapotaceae), an endemic tree of Morocco, produces argan press-cake (APC) used as a shampoo and to treat sprains, scabies, and for healing wounds. We have previously reported that argan oil has antimelanogenesis effect. Here, we determined if the by-product, APC, has melanogenesis regulatory effect using B16 murine melanoma cells. The effect of APC ethanol extract on cell proliferation and melanin content of B16 cells were measured, and to elucidate the mechanism involved, the expression level of melanogenic enzymes tyrosinase (TYR), dopachrome tautomerase (DCT), and tyrosinase-related protein 1 (TRP1) were determined and mRNA expression level of microphthalmia- associated transcription factor (Mitf) and Tyr genes were quantified. APC ethanol extract showed a significant melanin biosynthesis inhibitory effect on B16 cells in a time-dependent manner without cytotoxicity, which could be due to the decreased expression of TYR, TRP1, and DCT in a time-dependent manner. APC extract down regulated Mitf and Tyr. Decreased TRP1 and DCT levels could be due to post-translational modifications. These results suggest that APC extract may be used as a new source of natural whitening products and may be introduced as an important pharmacological agent for the treatment of hyperpigmentation disorders.

Published
2016

36. Neural substrates of levodopa‐responsive gait disorders and freezing in advanced Parkinson's disease: A kinesthetic imagery approach

Author

Maillet, Audrey, Thobois, Stéphane, Fraix, Valérie, Redoute, Jerome, Le Bars, Didier, Lavenne, Franck, Derost, Philippe, Durif, Franck, Bloem, Bastiaan, Krack, Paul, Pollak, Pierre, Debû, Bettina, Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Hospices Civils de Lyon (HCL), ANTE-INSERM U836, équipe 10, Dynamique des réseaux neuronaux du mouvement, UM des troubles du mouvement, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant (CERMEP - imagerie du vivant), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Department of Clinical Genetics, Département de neurologie, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Douhairie, Marie-Laurence, and Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)

Subjects
Male, Imagination/physiology, Parkinson's disease, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV.NEU.PC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, PET imaging, Gait disorders, Antiparkinson Agents, Levodopa, Gait Disorders, Neurologic/*drug therapy/etiology/physiopathology, Humans, Parkinson Disease/complications/*drug therapy/physiopathology, Kinesthesis, ComputingMilieux_MISCELLANEOUS, Research Articles, Gait Disorders, Neurologic, Aged, Levodopa/*pharmacology, Freezing of gait, [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior, [SCCO.NEUR]Cognitive science/Neuroscience, [SCCO.NEUR] Cognitive science/Neuroscience, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Kinesthetic motor imagery, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, Brain, Parkinson Disease, Middle Aged, Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3], ddc:616.8, Antiparkinson Agents/*pharmacology, Positron-Emission Tomography, Imagination, Female, Brain/*drug effects/physiopathology, [SDV.NEU.SC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, Kinesthesis/physiology
Abstract

Contains fulltext : 153489.pdf (Publisher’s version ) (Closed access) Gait disturbances, including freezing of gait, are frequent and disabling symptoms of Parkinson's disease. They often respond poorly to dopaminergic treatments. Although recent studies have shed some light on their neural correlates, their modulation by dopaminergic treatment remains quite unknown. Specifically, the influence of levodopa on the networks involved in motor imagery (MI) of parkinsonian gait has not been directly studied, comparing the off and on medication states in the same patients. We therefore conducted an [H2 (15) 0] Positron emission tomography study in eight advanced parkinsonian patients (mean disease duration: 12.3 +/- 3.8 years) presenting with levodopa-responsive gait disorders and FoG, and eight age-matched healthy subjects. All participants performed three tasks (MI of gait, visual imagery and a control task). Patients were tested off, after an overnight withdrawal of all antiparkinsonian treatment, and on medication, during consecutive mornings. The order of conditions was counterbalanced between subjects and sessions. Results showed that imagined gait elicited activations within motor and frontal associative areas, thalamus, basal ganglia and cerebellum in controls. Off medication, patients mainly activated premotor-parietal and pontomesencephalic regions. Levodopa increased activation in motor regions, putamen, thalamus, and cerebellum, and reduced premotor-parietal and brainstem involvement. Areas activated when patients are off medication may represent compensatory mechanisms. The recruitment of these accessory circuits has also been reported for upper-limb movements in Parkinson's disease, suggesting a partly overlapping pathophysiology between imagined levodopa-responsive gait disorders and appendicular signs. Our results also highlight a possible cerebellar contribution in the pathophysiology of parkinsonian gait disorders through kinesthetic imagery.

Published
2014

37. Contribution of local field potential to subthalamic nucleus deep brain stimulation in Parkinson's disease

Author

Coste, Jerome, Derost, Philippe P, Mulliez, Aurelien, Gabrillargues, Jean, Pereira, Bruno, Lemaire, Jean-Jacques, Service de Neurochirurgie [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand, Image Guided Clinical Neurosciences and Connectomics (IGCNC), Université d'Auvergne - Clermont-Ferrand I (UdA), Service de Neurologie [CHU Clermont-Ferrand], CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand-CHU Gabriel Montpied [Clermont-Ferrand], Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Direction de la recherche clinique et de l’innovation [CHU Clermont-Ferrand] (DRCI), Unité de Neuroradiologie, service de radiologie A, Fondation de l’Avenir | Projet ET7-455 « Développement d’outils d’électrophysiologie pour aider à la localisation et à la compréhension des mécanismes physiopathologiques durant l’implantation d’électrodes de stimulation cérébrale», Unité de Neuroradiologie, Service de Radiologie A, Fondation de l’Avenir | Projet ET7-455, Jean-Jacques LEMAIRE, IGCNC, Service de Neurochirurgie [CHU Clermont-Ferrand], CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, CHU Clermont-Ferrand-CHU Clermont-Ferrand-CHU Estaing [Clermont-Ferrand], and Unité de Biostatistiques [CHU Clermont-Ferrand]

Subjects
nervous system, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Tremor, Diagnostic Procedures, Other Movement Disorders, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Parkinsonism
Abstract

International audience; Introduction: The subthalamic nucleus (STN) is the main target for deep brain stimulation (DBS) in Parkinson’s disease. We analyzed the relationships between magnetic resonance imaging (MRI) anatomy and electrophysiology (local field potential, LFP) done during surgery.Objectives: We hypothesized that the contribution of LFP to neuronal firing rate with detailed MRI anatomy should allow to explore finely anatomo-electrophysiological relationships and also to determine precisely functional surgical targets.Methods:Ten patients with Parkinson’s disease (5F; mean age: 62±4 years; 11±3 years disease duration) underwent bilateral STN DBS surgical procedure.Electrophysiology: 693 LFP recordings in MRI-outlined anatomical structures (Thalamus [Thal], Zona Incerta [ZI], Forel Field [Forel] and STN) were analyzed: Power spectral densities (PSD) from 0 to 100Hz; 1024 frequency values; Normalization: percent of total PSD; Calculation for delta (0-4 Hz), theta (4-7 Hz), alpha (7-13 Hz), beta (13-30 Hz), gamma (30-50 Hz, 50-100 Hz) frequency range. Non-parametric Kruskal-Wallis ANOVA tests were performed followed by pairwise comparisons with adjusted p-value.Results: Percentage of power spectral density for main physiological LFP frequency range was considered for thalamus, ZI, STN and Forel (Figure).Conclusions: This study suggests the interest of LFP to discriminate between structures in the subthalamic region using exploration electrode with patient at rest during DBS surgery. Another part of this study will consist in correlating extracellular neuronal activity and LFP, and analyzing modulations on LFP during voluntary movements of patients.

Published
2013

38. Long-term efficacy and tolerability of bilateral pallidal stimulation to treat tardive dyskinesia

Author

Pouclet-Courtemanche, Hélène, primary, Rouaud, Tiphaine, additional, Thobois, Stephane, additional, Nguyen, Jean-Michel, additional, Brefel-Courbon, Christine, additional, Chereau, Isabelle, additional, Cuny, Emmanuel, additional, Derost, Philippe, additional, Eusebio, Alexandre, additional, Guehl, Dominique, additional, Laurencin, Chloé, additional, Mertens, Patrick, additional, Ory-Magne, Fabienne, additional, Raoul, Sylvie, additional, Regis, Jean, additional, Ulla, Miguel, additional, Witjas, Tatiana, additional, Burbaud, Pierre, additional, Rascol, Olivier, additional, and Damier, Philippe, additional

Published
2016
Full Text
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39. Subthalamus stimulation in Parkinson disease: Accounting for the bilaterality of contacts

Author

Lemaire, Jean-Jacques, primary, Pereira, Bruno, additional, Derost, Philippe, additional, Vassal, François, additional, Ulla, Miguel, additional, Morand, Dominique, additional, Coll, Guillaume, additional, Gabrillargues, Jean, additional, Marques, Ana, additional, Debilly, Bérangère, additional, Coste, Jérôme, additional, and Durif, Franck, additional

Published
2016
Full Text
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40. Surgical complications of deep brain stimulation: Clinical experience of 184 cases

Author

Mendes Martins, Vivien, Coste, Jérôme, Derost, Philippe, Ulla, Miguel, Gabrillargues, Jean, Durif, Franck, Chazal, Jean, Lemaire, Jean-Jacques, Image Guided Clinical Neurosciences and Connectomics (IGCNC), Université d'Auvergne - Clermont-Ferrand I (UdA), Service de Neurochirurgie [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand, Service de Neurologie [CHU Clermont-Ferrand], CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand-CHU Gabriel Montpied [Clermont-Ferrand], Service de Radiologie, Unité de Neuroradiologie, Service de Neurochirurgie [CHU Clermont-Ferrand], CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, and CHU Clermont-Ferrand-CHU Clermont-Ferrand-CHU Estaing [Clermont-Ferrand]

Subjects
Stimulation cérébrale profonde, Visée directe, Surgical complications, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery, Subthalamic nucleus, Direct targeting, Noyau sous-thalamique, Globus pallidum interne, Thalamus, Complications chirurgicales, Globus pallidus internus, Deep brain stimulation, [SDV.MHEP.AHA]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]
Abstract

International audience; Background and purpose: Deep brain stimulation (DBS) is an effective treatment of movement disorders and psychiatric diseases. However, this surgery is still time consuming and associated with complications, among which we aimed to identify non-stimulo-induced adverse effects. Hence, we retrospectively systematically analyzed patients operated on, at our institution, using magnetic resonance imaging (MRI) direct anatomic mapping.Methods: One hundred and seventy-five patients (184 surgeries) were performed between 1994 and 2008, for Parkinson's disease, essential tremor, dystonia and obsessive compulsive disorder. Primary anatomic targets were the subthalamic region, the intern pallidum and the thalamus. Final electrode positioning was adjusted according to intraoperative neuron recordings and acute stimulation tests. All surgically related adverse effects were collected. Life threatening or new non-planed surgery was considered as severe adverse effects.Results: Adverse effects occurred 10 times (5.4%) during MRI acquisition, 24 times (13%) with five serious (2.7%) including one1 death (0.5%) during electrodes implantation and 17 times (9.2%) with four serious (2.2%) during neuropacemaker implantation. Electrodes were repositioned in six cases (five patients, n = 3.4%).Conclusion: DBS efficiency is recognized however the significant incidence of adverse effects should prompt us to improve the procedures; Introduction: La stimulation cérébrale profonde est un traitement reconnu des mouvements anormaux et de certains troubles psychiatriques. Néanmoins, il s’agit toujours d’une procédure chirurgicale longue, délicate et à l’origine de complications. Nous avons analysé les évènements indésirables non stimulo-induits survenus sur 14 ans au CHU de Clermont-Ferrand où nous réalisons une visée stéréotaxique directe à partir d’une imagerie par résonance magnétique nucléaire (IRM).Patients et méthode: Cent soixante-quinze patients (184 interventions) ont été réalisés entre 1994 et 2008 pour : maladie de Parkinson idiopathique, tremblement essentiel, dystonie et trouble obsessionnel compulsif. Les cibles anatomiques primaires visées étaient : la région sous-thalamique, le pallidum interne ou le thalamus. Les électrodes ont été positionnées après enregistrement neuronal et tests aigus de stimulation. Tous les évènements indésirables ont été recueillis et analysés rétrospectivement ; l’engagement du pronostic vital ou une ré-intervention non programmée ont été considérés comme évènements indésirables graves.Résultats: Le taux d’évènements indésirables par intervention était de 5,4 % lors de la réalisation de l’IRM (dix cas), de 13 % lors du positionnement d’électrodes (24 cas ; cinq cas graves incluant 1 décès, 0,5 %), et de 9,2 % lors de l’implantation du neurostimulateur (17 cas ; quatre graves, 2,2 %). Cinq patients (six chirurgies ; 3,4 %) ont eu un repositionnement d’électrodes.Conclusion : L’efficacité de la stimulation cérébrale profonde n’est plus à prouver, mais la fréquence non négligeable des évènements indésirables doit nous inciter à améliorer les procédures.

Published
2012

41. Stimulation cérébrale profonde: évènements indésirables au cours de 184 procédures

Author

Vivien Mendes Martins, Jérôme Coste, Derost, Philippe P., Miguel Ulla, Franck Durif, Ana Raquel Marques, Jean Gabrillargues, Emmnuel Chabert, Béatrice Claise, Laurent Sakka, Toufic Khalil, Aurélien Coste, Guillaume Coll, Jean Chazal, Jean Jacques Lemaire, Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Université d'Auvergne - Clermont-Ferrand I (UdA), Service de Neurologie [CHU Clermont-Ferrand], CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand-CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand, Image Science for Interventional Techniques (ISIT), Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université-Centre National de la Recherche Scientifique (CNRS), École Centrale de Nantes (ECN), Service de Neurochirurgie [CHU Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Equipe de Recherche en Signal et Imagerie Medicale (ERIM-ERI 14), Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Clermont-Ferrand-Université d'Auvergne - Clermont-Ferrand I (UdA), Service de radiologie, unité de neuroradiologie, Unité de Neuroradiologie, service de radiologie A, Unité de Neuroradiologie, Service de Radiologie A, Société de Neurochirurgie de Langue Française, Service de Neurochirurgie [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Gabriel Montpied [Clermont-Ferrand], CHU Estaing [Clermont-Ferrand], and CHU Clermont-Ferrand-CHU Clermont-Ferrand-CHU Gabriel Montpied [Clermont-Ferrand]

Subjects
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery, ComputingMilieux_MISCELLANEOUS, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience

Published
2010

43. Clinique du syndrome de Gilles de la Tourette chez l'adulte

Author

Jalenques, Isabelle, Galland, Fabienne, Legrand, G., Derost, Philippe, Mermillod, Martial, Auxiette, Catherine, Chambres, Patrick, Durif, Franck, Laboratoire de psychologie sociale et de psychologie cognitive (LAPSCO), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Centre National de la Recherche Scientifique (CNRS), and Veyssiere, Delphine

Subjects
[SCCO.PSYC] Cognitive science/Psychology, [SCCO.PSYC]Cognitive science/Psychology
Published
2008

44. Somatotopie observée dans le GPi: analyse d'effets moteurs indésirables au cours d'une stimulation cérébrale profonde chez un patient parkinsonien

Author

Coste, Jerome, Hemm, Simone, Ulla, Miguel, Derost, Philippe, Caire, François, Durif, Franck, Lemaire, Jean-Jacques, Neurobiologie de la Douleur Trigéminale (EMI 0216), Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Neurochirurgie [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand, Equipe de Recherche en Signal et Imagerie Medicale (ERIM-ERI 14), Service de Neurologie [CHU Clermont-Ferrand], CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand-CHU Gabriel Montpied [Clermont-Ferrand], Institut Fédératif de Recherche 79 - Santé Auvergne, Service de Neurochirurgie [CHU Limoges], CHU Limoges, European Society for Stereotactic and Functional Neurosurgery (ESSFN), Service de Neurochirurgie [CHU Clermont-Ferrand], CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, and CHU Clermont-Ferrand-CHU Clermont-Ferrand-CHU Estaing [Clermont-Ferrand]

Subjects
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Abstract

National audience; Objectif : plusieurs auteur ont décrit une somatotopie dans le globus pallidus (GP) de l’homme, à partir des enregistrements électrophysiologiques effectués au cours de neurochirurgies, en considérant des mouvements volontaires ou passifs des patients, ou encore sur les effets cliniques des stimulations cérébrales profondes (SCP) effectuées pour traiter les mouvements anormaux. Le présent travail montre une somatotopie des mouvements indésirables (dystonies) observée dans le pallidum d’un patient parkinsonien pendant la stimulation aigue. Ces données sont mises en correspondance avec l’anatomie IRM.Méthode : un patient parkinsonien souffrant principalement de dyskinésies des membres et du tronc (16 ans d’évolution de la maladie, 68 ans) a bénéficié d’une CSP bilatérale du GP interne (GPi) en condition stéréotaxique avec une approche en visée directe. Une IRM T2 permet de discerner les différentes structures pallidales : GP externe (GPe) et les subdivisions du GPi (latérale GPil et médiale GPim). Des mouvements dystoniques controlatéraux ont été observés à l’aide de 2 x 3 électrodes parallèles et séparées de 2 mm pendant la stimulation effectuée sous anesthésie locale. Les mouvements dystoniques concernant le visage, les membres supérieurs et inférieurs ont été visualisés dans les structures anatomiques étudiées.Résultats : chacune des structures GPe, GPil et GPim semble présenter une organisation rostro-caudale avec le visage représenté dans la partie supérieure, les membres supérieurs dans la région intermédiaire et les membres inférieurs dans la portion inférieure.Conclusion : l’analyse des effets moteurs indésirables (dystonie) est ici un outil intéressant pour dessiner une somatotopie. Cette somatotopie pallidale, observée chez un patient, doit cependant être validée.

Published
2006

45. Somatotopy in the GPi: Analysis of Motor Side Effects during Intraoperative Assessment in a Parkinsonian

Author

Coste, Jerome, Hemm, Simone, Ulla, Miguel, Derost, Philippe, Caire, François, Durif, Franck, Lemaire, Jean-Jacques, Neurobiologie de la Douleur Trigéminale (EMI 0216), Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Neurochirurgie [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand, Equipe de Recherche en Signal et Imagerie Medicale (ERIM-ERI 14), Service de Neurologie [CHU Clermont-Ferrand], CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand-CHU Gabriel Montpied [Clermont-Ferrand], Institut Fédératif de Recherche 79 - Santé Auvergne, and Coste, Jérôme

Subjects
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Abstract

National audience; Objectif : plusieurs auteur ont décrit une somatotopie dans le globus pallidus (GP) de l’homme, à partir des enregistrements électrophysiologiques effectués au cours de neurochirurgies, en considérant des mouvements volontaires ou passifs des patients, ou encore sur les effets cliniques des stimulations cérébrales profondes (SCP) effectuées pour traiter les mouvements anormaux. Le présent travail montre une somatotopie des mouvements indésirables (dystonies) observée dans le pallidum d’un patient parkinsonien pendant la stimulation aigue. Ces données sont mises en correspondance avec l’anatomie IRM.Méthode : un patient parkinsonien souffrant principalement de dyskinésies des membres et du tronc (16 ans d’évolution de la maladie, 68 ans) a bénéficié d’une CSP bilatérale du GP interne (GPi) en condition stéréotaxique avec une approche en visée directe. Une IRM T2 permet de discerner les différentes structures pallidales : GP externe (GPe) et les subdivisions du GPi (latérale GPil et médiale GPim). Des mouvements dystoniques controlatéraux ont été observés à l’aide de 2 x 3 électrodes parallèles et séparées de 2 mm pendant la stimulation effectuée sous anesthésie locale. Les mouvements dystoniques concernant le visage, les membres supérieurs et inférieurs ont été visualisés dans les structures anatomiques étudiées.Résultats : chacune des structures GPe, GPil et GPim semble présenter une organisation rostro-caudale avec le visage représenté dans la partie supérieure, les membres supérieurs dans la région intermédiaire et les membres inférieurs dans la portion inférieure.Conclusion : l’analyse des effets moteurs indésirables (dystonie) est ici un outil intéressant pour dessiner une somatotopie. Cette somatotopie pallidale, observée chez un patient, doit cependant être validée.

Published
2006

46. Weight gain mecanisms after deep brain stimulation of the subthalamic nucleus in Parkinson’s disease patients

Author

Derost, Philippe, Bannier, S., Montaurier, Christophe, Morio, Béatrice, Durif, Franck, Département de Neurologie, Mayo Clinic Rochester, Unité de Nutrition Humaine (UNH), Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université-Institut National de la Recherche Agronomique (INRA), Unité de Nutrition Humaine - Clermont Auvergne (UNH), and Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA)

Subjects
gain de poids, physical exercise, primary Parkinsonism, [SDV]Life Sciences [q-bio], education, liveweight gain, maladie de parkinson, stimulation, health care economics and organizations, chirurgie, nervous system diseases, activité physique
Abstract

Weight gain mecanisms after deep brain stimulation of the subthalamic nucleus in Parkinson’s disease patients. 10. International Congress of Parkinson's Disease and Movement Disorders

Published
2006

47. Relationships between MRI anatomy and electrophysiological spontaneous unitary recordings in the subthalamic region during stereotactic surgery for severe idiopathic Parkinson’s disease

Author

Coste, Jerome, Siadoux, Séverine, Derost, Philippe, Durif, Franck, Gabrillargues, Jean, Hemm, Simone, Lemaire, Jean-Jacques, Service de Neurochirurgie [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand, Equipe de Recherche en Signal et Imagerie Medicale (ERIM-ERI 14), Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Neurologie [CHU Clermont-Ferrand], CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand-CHU Gabriel Montpied [Clermont-Ferrand], European Society for Stereotactic and Functional Neurosurgery (ESSFN), Service de Neurochirurgie [CHU Clermont-Ferrand], CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, CHU Clermont-Ferrand-CHU Clermont-Ferrand-CHU Estaing [Clermont-Ferrand], and Coste, Jérôme

Subjects
surgical procedures, operative, nervous system, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, nervous system diseases
Abstract

International audience; Objective. In the subthalamic area, the subthalamic nucleus (STN) is the main target for deep brain stimulation (DBS) in idiopathic Parkinson’s disease (PD). We aimed at analysing relationships between the MRI anatomy and spontaneous neuronal activity in order to confirm the potential of microelectrode recording to assist in the determination of the optimal surgical target.Methods. Thirty trajectories were analysed. Procedures (8 bilateral surgeries) were performed under local anaesthesia after identification on 1.5T MRI (T2 weighted) of anatomical structures, STN, above STN (zona incerta, forel’s fields) and substantia nigra (SN). Spontaneous neuronal activity was recorded (30 seconds, 0.5 mm step), simultaneously along the distal 10 mm on a central (covering optimally STN) and on a 2 mm anterior track. Intra operative X-Ray controls checked that the exploration tracts followed the planed trajectories. Chronic DBS (on central tract 14 times outof 16) dramatically improved PD. We calculated cell numbers and mean firing rates (MFR, average firing on 30 seconds) on 276 isolated neurons (after threshold and principal component analysis) regrouped according to anatomical structures. MFR were compared with a non parametric statistical test.Results. 60% of spontaneously active cells were in the dorsal and lateral STN. MFR increased entering STN and SN (p

Published
2006

48. Comparison between atlas based diagrams used for indirect STN targeting and STN templates determined directly on stereotactic MRI

Author

Caire, François, Ouchchane, Lemlih, Coste, Jerome, Derost, Philippe P, Lemaire, Jean-Jacques, Service de Neurochirurgie [CHU Limoges], CHU Limoges, Service de Neurochirurgie [CHU Clermont-Ferrand], CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Equipe de Recherche en Signal et Imagerie Medicale (ERIM-ERI 14), Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Biostatistique, Informatique médicale et Technologies de la communication, CHU Clermont-Ferrand-Université d'Auvergne - Clermont-Ferrand I (UdA), Service de Neurologie [CHU Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand-CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand, Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), European Society for Stereotactic and Functional Neurosurgery (ESSFN), Service de Neurochirurgie [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Gabriel Montpied [Clermont-Ferrand], CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand-CHU Gabriel Montpied [Clermont-Ferrand], and Coste, Jérôme

Subjects
surgical procedures, operative, [SDV.MHEP.CHI] Life Sciences [q-bio]/Human health and pathology/Surgery, nervous system, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [INFO.INFO-IM] Computer Science [cs]/Medical Imaging, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, [SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery, nervous system diseases
Abstract

International audience; Objective. Stereotactic determination of the subthalamic nucleus (STN) target is based on diagrams (indirect statistical coordinates relatively to anterior and posterior commissures AC, PC) or on direct MRI visualization. We aimed to compare both methods.Methods. We studied 30 STN in 15 parkinsonian patients operated on for bilateral electrode placement. STN, AC and PC were identified on stereotactic 1.5-Tesla MRI slices (stereotactic frame in place; T2 weighted). We outlined STN boundaries on coronal slices. We defined a lateral template (hexagonal shape; on the sagittal slice where STN was widest) then 3 frontal templates (quadrilateral shape) located on the anterior, the intermediate and the posterior borders of lateral STN template. We built Guiot’s (modified by Benabid et al.) and Talairach’s STN diagrams. We tested discordance, using paired means comparisons, on locations of centres between STN diagrams and templates, for both frontal and lateral views.Results. There were significant differences (p

Published
2006

49. Stimulation sous-thalamique dans la maladie de Parkinson sévère: Étude de la localisation des contacts effectifs

Author

Caire, François, Derost, Philippe P, Coste, Jerome, Bonny, Jean-Marie, Durif, Franck, Frenoux, Emmanuelle, Villéger, Alice, Lemaire, Jean-Jacques, Service de Neurochirurgie [CHU Clermont-Ferrand], CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Service de Neurochirurgie [CHU Limoges], CHU Limoges, Service de Neurologie [CHU Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand-CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand, Neurobiologie de la douleur trigéminale (Clermont-Ferrand), Structures tissulaires et interactions moléculaires (STIM), Institut National de la Recherche Agronomique (INRA), Equipe de Recherche en Signal et Imagerie Medicale (ERIM-ERI 14), Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Neurochirurgie A [Clermont-Ferrand], CHU Clermont-Ferrand-Hôpital Gabriel Montpied, Service de neurologie, Hôpital Gabriel Montpied, CHU Clermont-Ferrand-CHU Gabriel Montpied [Clermont-Ferrand], CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand-CHU Gabriel Montpied [Clermont-Ferrand], and Coste, Jérôme

Subjects
anatomy, [SDV.MHEP.CHI] Life Sciences [q-bio]/Human health and pathology/Surgery, Parkinson's disease, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery, MR imaging, deep brain stimulation
Abstract

The subthalamic nucleus (STN) is the main target of deep brain stimulation (DBS) treatment for severe idiopathic Parkinson's disease. But there is still no clear information on the location of the effective contacts (used during the chronic phase of stimulation). Our aim was to assess the anatomical structures of the subthalamic area (STA) involved during chronic DBS. Ten patients successfully treated were included. The surgical procedure was based on direct STN targeting (stereotactic MRI based) pondered by the acute effects of intraoperative stimulation. We used a formaldehyde-fixed human specimen to compare by matching MRI images obtained at 1.5 Tesla (performed in clinical stereotactic conditions) and at very high field at 4.7 Tesla. This allowed accurate analysis of the anatomy of the STA and retrospective precision of the location of the center of effective contacts which were located within the STN in 4 patients, at the interface between the STN and the ZI and/or FF in 13, at the interface between ZI and FF in 2 and between the STN and the substantia nigra in one. These results were consistent with the literature, revealing the implication of neighboring structures, especially the zona incerta and Forel's Field, in the clinical benefit., Le noyau sous-thalamique (NST) s’est imposé comme la cible de choix de la stimulation cérébrale profonde (SCP) dans la maladie de Parkinson idiopathique sévère. Toutefois, la position des contacts utilisés lors de la stimulation chronique (contacts effectifs) reste mal connue. Notre but était de préciser, au sein de la région sous-thalamique (RST), la topographie des contacts effectifs. Pour cela, nous avons réalisé en préalable un travail sur spécimen anatomique, par mise en correspondance d’images IRM à 1,5 Tesla (en conditions cliniques) et à très haut champ à 4,7 Tesla, explorant la RST. Nous avons ensuite étudié une série de 10 patients traités par DBS bilatérale avec un bon résultat clinique. L’implantation avait été réalisée en visée directe (repérage direct du STN sur IRM stéréotaxique) pondérée en fonction des effets de la stimulation aiguë per-opératoire. Nous avons revu a posteriori, en s’aidant de l’anatomie IRM très haut champ, la position du centre des contacts effectifs. Si certains contacts étaient placés à l’intérieur du NST (4 fois), la plupart se trouvaient à l’interface de ce dernier et de la zona incerta et/ou des champs de Forel (13 fois), à l’interface zona incerta et champs de Forel (2 fois) et à l’interface NST substance noire (1 fois). Ces résultats sont en accord avec la littérature. L’implication des structures voisines du NST dans le bénéfice clinique, en particulier la zona incerta et le champ de Forel, semble donc probable.

Published
2006

50. Mécanismes de la prise de poids chez le patient parkinsonien après stimulation sous-thalamique : implication des modifications de la dépense énergétique

Author

Montaurier, Christophe, Morio, Béatrice, Derost, Philippe, Arnaud, P., Boirie, Yves, Durif, Franck, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Département Neurologie, Centre Hospitalier Universitaire de Clermont-Ferrand, Unité de Nutrition Humaine (UNH), Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université-Institut National de la Recherche Agronomique (INRA), CHU Clermont-Ferrand, Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université, Service de Neurologie [CHU Clermont-Ferrand], CHU Gabriel Montpied [Clermont-Ferrand], and CHU Clermont-Ferrand-CHU Clermont-Ferrand-CHU Estaing [Clermont-Ferrand]

Subjects
prise de poids, mechanistic theory, primary Parkinsonism, [SDV]Life Sciences [q-bio], maladie de parkinson, dépense énergétique, mécanisme, energy expenses
Abstract

Mécanismes de la prise de poids chez le patient parkinsonien après stimulation sous-thalamique : implication des modifications de la dépense énergétique. 24.Congrès de la Société Francophone de Nutrition Entérale et Parentérale (SFNEP)

Published
2005

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