Search

Your search keyword '"Derosa, Lisa"' showing total 481 results
Start Over Author "Derosa, Lisa"
481 results on '"Derosa, Lisa"'

1. Correction: Acyl-coenzyme a binding protein (ACBP) - a risk factor for cancer diagnosis and an inhibitor of immunosurveillance

Author

Montégut, Léa, Liu, Peng, Zhao, Liwei, Pérez-Lanzón, María, Chen, Hui, Mao, Misha, Zhang, Shuai, Derosa, Lisa, Naour, Julie Le, Lambertucci, Flavia, Mingoia, Silvia, Nogueira-Recalde, Uxía, Mena-Osuna, Rafael, Herranz-Montoya, Irene, Djouder, Nabil, Baulande, Sylvain, Pan, Hui, Joseph, Adrien, Messaoudene, Meriem, Routy, Bertrand, Fidelle, Marine, Ben Ahmed, Tarek, Caron, Olivier, Busson, Pierre, Boulate, David, Deschasaux-Tanguy, Mélanie, Arnault, Nathalie, Pol, Jonathan G., Piaggio, Eliane, Touvier, Mathilde, Zitvogel, Laurence, Delaloge, Suzette, Martins, Isabelle, and Kroemer, Guido

Published
2024
Full Text
View/download PDF

2. Acyl-coenzyme a binding protein (ACBP) - a risk factor for cancer diagnosis and an inhibitor of immunosurveillance

Author

Montégut, Léa, Liu, Peng, Zhao, Liwei, Pérez-Lanzón, María, Chen, Hui, Mao, Misha, Zhang, Shuai, Derosa, Lisa, Naour, Julie Le, Lambertucci, Flavia, Mingoia, Silvia, Nogueira-Recalde, Uxía, Mena-Osuna, Rafael, Herranz-Montoya, Irene, Djouder, Nabil, Baulande, Sylvain, Pan, Hui, Joseph, Adrien, Messaoudene, Meriem, Routy, Bertrand, Fidelle, Marine, Ben Ahmed, Tarek, Caron, Olivier, Busson, Pierre, Boulate, David, Deschasaux-Tanguy, Mélanie, Arnault, Nathalie, Pol, Jonathan G., Piaggio, Eliane, Touvier, Mathilde, Zitvogel, Laurence, Delaloge, Suzette, Martins, Isabelle, and Kroemer, Guido

Published
2024
Full Text
View/download PDF

4. Influence of microbiota-associated metabolic reprogramming on clinical outcome in patients with melanoma from the randomized adjuvant dendritic cell-based MIND-DC trial

Author

Alves Costa Silva, Carolina, Piccinno, Gianmarco, Suissa, Déborah, Bourgin, Mélanie, Schreibelt, Gerty, Durand, Sylvère, Birebent, Roxanne, Fidelle, Marine, Sow, Cissé, Aprahamian, Fanny, Manghi, Paolo, Punčochář, Michal, Asnicar, Francesco, Pinto, Federica, Armanini, Federica, Terrisse, Safae, Routy, Bertrand, Drubay, Damien, Eggermont, Alexander M. M., Kroemer, Guido, Segata, Nicola, Zitvogel, Laurence, Derosa, Lisa, Bol, Kalijn F., and de Vries, I. Jolanda M.

Published
2024
Full Text
View/download PDF

5. Longitudinal gut microbiome changes in immune checkpoint blockade-treated advanced melanoma

Author

Björk, Johannes R., Bolte, Laura A., Maltez Thomas, Andrew, Lee, Karla A., Rossi, Niccolo, Wind, Thijs T., Smit, Lotte M., Armanini, Federica, Asnicar, Francesco, Blanco-Miguez, Aitor, Board, Ruth, Calbet-Llopart, Neus, Derosa, Lisa, Dhomen, Nathalie, Brooks, Kelly, Harland, Mark, Harries, Mark, Lorigan, Paul, Manghi, Paolo, Marais, Richard, Newton-Bishop, Julia, Nezi, Luigi, Pinto, Federica, Potrony, Miriam, Puig, Susana, Serra-Bellver, Patricio, Shaw, Heather M., Tamburini, Sabrina, Valpione, Sara, Waldron, Levi, Zitvogel, Laurence, Zolfo, Moreno, de Vries, Elisabeth G. E., Nathan, Paul, Fehrmann, Rudolf S. N., Spector, Tim D., Bataille, Véronique, Segata, Nicola, Hospers, Geke A. P., and Weersma, Rinse K.

Published
2024
Full Text
View/download PDF

7. Correction: Metabolomic analyses of COVID-19 patients unravel stage-dependent and prognostic biomarkers

Author

Danlos, François-Xavier, Grajeda-Iglesias, Claudia, Durand, Sylvère, Sauvat, Allan, Roumier, Mathilde, Cantin, Delphine, Colomba, Emeline, Rohmer, Julien, Pommeret, Fanny, Baciarello, Giulia, Willekens, Christophe, Vasse, Marc, Griscelli, Frank, Fahrner, Jean-Eudes, Goubet, Anne-Gaëlle, Dubuisson, Agathe, Derosa, Lisa, Nirmalathasan, Nitharsshini, Bredel, Delphine, Mouraud, Séverine, Pradon, Caroline, Stoclin, Annabelle, Rozenberg, Flore, Duchemin, Jérôme, Jourdi, Georges, Ellouze, Syrine, Levavasseur, Françoise, Albigès, Laurence, Soria, Jean-Charles, Barlesi, Fabrice, Solary, Eric, André, Fabrice, Pène, Frédéric, Ackerman, Félix, Mouthon, Luc, Zitvogel, Laurence, Marabelle, Aurélien, Michot, Jean-Marie, Fontenay, Michaela, and Kroemer, Guido

Published
2024
Full Text
View/download PDF

8. Fecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Author

Routy, Bertrand, Lenehan, John G., Miller, Jr, Wilson H., Jamal, Rahima, Messaoudene, Meriem, Daisley, Brendan A., Hes, Cecilia, Al, Kait F., Martinez-Gili, Laura, Punčochář, Michal, Ernst, Scott, Logan, Diane, Belanger, Karl, Esfahani, Khashayar, Richard, Corentin, Ninkov, Marina, Piccinno, Gianmarco, Armanini, Federica, Pinto, Federica, Krishnamoorthy, Mithunah, Figueredo, Rene, Thebault, Pamela, Takis, Panteleimon, Magrill, Jamie, Ramsay, LeeAnn, Derosa, Lisa, Marchesi, Julian R., Parvathy, Seema Nair, Elkrief, Arielle, Watson, Ian R., Lapointe, Rejean, Segata, Nicola, Haeryfar, S.M. Mansour, Mullish, Benjamin H., Silverman, Michael S., Burton, Jeremy P., and Maleki Vareki, Saman

Published
2023
Full Text
View/download PDF

9. Custom scoring based on ecological topology of gut microbiota associated with cancer immunotherapy outcome

Author

Derosa, Lisa, Iebba, Valerio, Silva, Carolina Alves Costa, Piccinno, Gianmarco, Wu, Guojun, Lordello, Leonardo, Routy, Bertrand, Zhao, Naisi, Thelemaque, Cassandra, Birebent, Roxanne, Marmorino, Federica, Fidelle, Marine, Messaoudene, Meriem, Thomas, Andrew Maltez, Zalcman, Gerard, Friard, Sylvie, Mazieres, Julien, Audigier-Valette, Clarisse, Sibilot, Denis Moro, Goldwasser, François, Scherpereel, Arnaud, Pegliasco, Hervé, Ghiringhelli, François, Bouchard, Nicole, Sow, Cissé, Darik, Ines, Zoppi, Silvia, Ly, Pierre, Reni, Anna, Daillère, Romain, Deutsch, Eric, Lee, Karla A., Bolte, Laura A., Björk, Johannes R., Weersma, Rinse K., Barlesi, Fabrice, Padilha, Lucas, Finzel, Ana, Isaksen, Morten L., Escudier, Bernard, Albiges, Laurence, Planchard, David, André, Fabrice, Cremolini, Chiara, Martinez, Stéphanie, Besse, Benjamin, Zhao, Liping, Segata, Nicola, Wojcik, Jérôme, Kroemer, Guido, and Zitvogel, Laurence

Published
2024
Full Text
View/download PDF

10. Melanoma and microbiota: Current understanding and future directions

Author

Routy, Bertrand, Jackson, Tanisha, Mählmann, Laura, Baumgartner, Christina K., Blaser, Martin, Byrd, Allyson, Corvaia, Nathalie, Couts, Kasey, Davar, Diwakar, Derosa, Lisa, Hang, Howard C., Hospers, Geke, Isaksen, Morten, Kroemer, Guido, Malard, Florent, McCoy, Kathy D., Meisel, Marlies, Pal, Sumanta, Ronai, Ze’ev, Segal, Eran, Sepich-Poore, Gregory D., Shaikh, Fyza, Sweis, Randy F., Trinchieri, Giorgio, van den Brink, Marcel, Weersma, Rinse K., Whiteson, Katrine, Zhao, Liping, McQuade, Jennifer, Zarour, Hassane, and Zitvogel, Laurence

Published
2024
Full Text
View/download PDF

11. Gut microbiome predicts gastrointestinal toxicity outcomes from chemoradiation therapy in patients with head and neck squamous cell carcinoma

Author

Hes, Cecilia, Desilets, Antoine, Tonneau, Marion, El Ouarzadi, Omar, De Figueiredo Sousa, Marina, Bahig, Houda, Filion, Édith, Nguyen-Tan, Phuc Felix, Christopoulos, Apostolos, Benlaïfaoui, Myriam, Derosa, Lisa, Alves Costa Silva, Carolina, Ponce, Mayra, Malo, Julie, Belkad, Wiam, Charpentier, Danielle, Aubin, Francine, Hamilou, Zineb, Jamal, Rahima, Messaoudene, Meriem, Soulières, Denis, and Routy, Bertrand

Published
2024
Full Text
View/download PDF

12. Author Correction: Fecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Author

Routy, Bertrand, Lenehan, John G., Miller, Jr, Wilson H., Jamal, Rahima, Messaoudene, Meriem, Daisley, Brendan A., Hes, Cecilia, Al, Kait F., Martinez-Gili, Laura, Punčochář, Michal, Ernst, Scott, Logan, Diane, Belanger, Karl, Esfahani, Khashayar, Richard, Corentin, Ninkov, Marina, Piccinno, Gianmarco, Armanini, Federica, Pinto, Federica, Krishnamoorthy, Mithunah, Figueredo, Rene, Thebault, Pamela, Takis, Panteleimon, Magrill, Jamie, Ramsay, LeeAnn, Derosa, Lisa, Marchesi, Julian R., Parvathy, Seema Nair, Elkrief, Arielle, Watson, Ian R., Lapointe, Rejean, Segata, Nicola, Haeryfar, S.M. Mansour, Mullish, Benjamin H., Silverman, Michael S., Burton, Jeremy P., and Maleki Vareki, Saman

Published
2024
Full Text
View/download PDF

13. Efficacy and Safety of Concomitant Proton Pump Inhibitor and Nivolumab in Renal Cell Carcinoma: Results of the GETUG-AFU 26 NIVOREN Multicenter Phase II Study

Author

Rassy, Elie, Dalban, Cécile, Colomba, Emeline, Derosa, Lisa, Alves Costa Silva, Carolina, Negrier, Sylvie, Chevreau, Christine, Gravis, Gwenaelle, Oudard, Stephane, Laguerre, Brigitte, Barthelemy, Philippe, Goupil, Marine Gross, Geoffrois, Lionnel, Rolland, Frederic, Thiery-Vuillemin, Antoine, Joly, Florence, Ladoire, Sylvain, Tantot, Florence, Escudier, Bernard, and Albiges, Laurence

Published
2022
Full Text
View/download PDF

14. Benzodiazepines compromise the outcome of cancer immunotherapy.

Author

Montégut, Léa, Derosa, Lisa, Messaoudene, Meriem, Chen, Hui, Lambertucci, Flavia, Routy, Bertrand, Zitvogel, Laurence, Martins, Isabelle, and Kroemer, Guido

Abstract

Acyl CoA binding protein (ACBP, which is encoded by diazepam binding inhibitor, DBI) acts on the gamma-amino butyric acid (GABA) receptor type A via a specific binding site that is shared by diazepam and other benzodiazepines. Both ACBP/DBI and benzodiazepines act as positive allosteric modulators, hence increasing GABA effects on this receptor. Recently, we found that ACBP/DBI acts as an endogenous immunosuppressor, meaning that its antibody-mediated neutralization has immunostimulatory effects and enhances the efficacy of immunotherapy and chemoimmunotherapy in mouse models. Driven by these considerations, we investigated whether diazepam administration in mice would reverse the beneficial effects of ACBP/DBI neutralization on cancer chemoimmunotherapy. Indeed, diazepam abolished the therapeutic of anti-ACBP/DBI antibodies, supporting the idea that diazepam exerts immunosuppressive properties. Of note, treatment with benzodiazepines was associated with poor clinical responses to chemoimmunotherapy in patients with non-small cell lung cancer (NSCLC) as compared to individuals not receiving any psychotropic drugs. Medication with other psychotropic drugs than benzodiazepines did not compromise the outcome of chemoimmunotherapy, indicating that this immunosuppressive effect was benzodiazepine specific. We conclude that benzodiazepines may confer systemic immunosuppression. This hypothesis requires further epidemiological and clinical confirmation. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

15. Faecalibacterium prausnitzii strain EXL01 boosts efficacy of immune checkpoint inhibitors.

Author

Bredon, Marius, Danne, Camille, Pham, Hang Phuong, Ruffié, Pauline, Bessede, Alban, Rolhion, Nathalie, Creusot, Laura, Brot, Loic, Alonso, Iria, Langella, Philippe, Derosa, Lisa, Cortot, Alexis B., Routy, Bertrand, Zitvogel, Laurence, Segata, Nicola, and Sokol, Harry

Abstract

Gut microbiota impacts responses to immune checkpoint inhibitors (ICI). A high level of Faecalibacterium prausnitzii have been associated with a positive response to ICI in multiple cancer types. Here, based on fecal shotgun metagenomics data, we show in two independent cohorts of patients with non-small cell lung cancer and advanced melanoma that a high level of F. prausnitzii at baseline is positively associated with a better clinical response to ICI. In MCA205 tumor-bearing mice, administration of F.prausnitzii strain EXL01, already in clinical development for Inflammatory Bowel Disease, restores the anti-tumor response to ICI in the context of antibiotic-induced microbiota perturbation at clinical and tumor transcriptomics level. In vitro, EXL01 strain enhances T cell activation in the presence of ICI. Interestingly, oral administration of EXL01 strain did not induce any change in fecal microbiota diversity or composition, suggesting a direct effect on immune cells in the small intestine. F. prausnitzii strain EXL01 will be evaluated as an adjuvant to ICI in multiple cancers in the near future. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

16. Cross-cohort gut microbiome associations with immune checkpoint inhibitor response in advanced melanoma

Author

Lee, Karla A., Thomas, Andrew Maltez, Bolte, Laura A., Björk, Johannes R., de Ruijter, Laura Kist, Armanini, Federica, Asnicar, Francesco, Blanco-Miguez, Aitor, Board, Ruth, Calbet-Llopart, Neus, Derosa, Lisa, Dhomen, Nathalie, Brooks, Kelly, Harland, Mark, Harries, Mark, Leeming, Emily R., Lorigan, Paul, Manghi, Paolo, Marais, Richard, Newton-Bishop, Julia, Nezi, Luigi, Pinto, Federica, Potrony, Miriam, Puig, Susana, Serra-Bellver, Patricio, Shaw, Heather M., Tamburini, Sabrina, Valpione, Sara, Vijay, Amrita, Waldron, Levi, Zitvogel, Laurence, Zolfo, Moreno, de Vries, Elisabeth G. E., Nathan, Paul, Fehrmann, Rudolf S. N., Bataille, Véronique, Hospers, Geke A. P., Spector, Tim D., Weersma, Rinse K., and Segata, Nicola

Published
2022
Full Text
View/download PDF

17. Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer

Author

Derosa, Lisa, Routy, Bertrand, Thomas, Andrew Maltez, Iebba, Valerio, Zalcman, Gerard, Friard, Sylvie, Mazieres, Julien, Audigier-Valette, Clarisse, Moro-Sibilot, Denis, Goldwasser, François, Silva, Carolina Alves Costa, Terrisse, Safae, Bonvalet, Melodie, Scherpereel, Arnaud, Pegliasco, Hervé, Richard, Corentin, Ghiringhelli, François, Elkrief, Arielle, Desilets, Antoine, Blanc-Durand, Felix, Cumbo, Fabio, Blanco, Aitor, Boidot, Romain, Chevrier, Sandy, Daillère, Romain, Kroemer, Guido, Alla, Laurie, Pons, Nicolas, Le Chatelier, Emmanuelle, Galleron, Nathalie, Roume, Hugo, Dubuisson, Agathe, Bouchard, Nicole, Messaoudene, Meriem, Drubay, Damien, Deutsch, Eric, Barlesi, Fabrice, Planchard, David, Segata, Nicola, Martinez, Stéphanie, Zitvogel, Laurence, Soria, Jean-Charles, and Besse, Benjamin

Published
2022
Full Text
View/download PDF

18. Prolonged SARS-CoV-2 RNA virus shedding and lymphopenia are hallmarks of COVID-19 in cancer patients with poor prognosis

Author

Goubet, Anne-Gaëlle, Dubuisson, Agathe, Geraud, Arthur, Danlos, François-Xavier, Terrisse, Safae, Silva, Carolina Alves Costa, Drubay, Damien, Touri, Lea, Picard, Marion, Mazzenga, Marine, Silvin, Aymeric, Dunsmore, Garett, Haddad, Yacine, Pizzato, Eugenie, Ly, Pierre, Flament, Caroline, Melenotte, Cléa, Solary, Eric, Fontenay, Michaela, Garcia, Gabriel, Balleyguier, Corinne, Lassau, Nathalie, Maeurer, Markus, Grajeda-Iglesias, Claudia, Nirmalathasan, Nitharsshini, Aprahamian, Fanny, Durand, Sylvère, Kepp, Oliver, Ferrere, Gladys, Thelemaque, Cassandra, Lahmar, Imran, Fahrner, Jean-Eudes, Meziani, Lydia, Ahmed-Belkacem, Abdelhakim, Saïdani, Nadia, La Scola, Bernard, Raoult, Didier, Gentile, Stéphanie, Cortaredona, Sébastien, Ippolito, Giuseppe, Lelouvier, Benjamin, Roulet, Alain, Andre, Fabrice, Barlesi, Fabrice, Soria, Jean-Charles, Pradon, Caroline, Gallois, Emmanuelle, Pommeret, Fanny, Colomba, Emeline, Ginhoux, Florent, Kazandjian, Suzanne, Elkrief, Arielle, Routy, Bertrand, Miyara, Makoto, Gorochov, Guy, Deutsch, Eric, Albiges, Laurence, Stoclin, Annabelle, Gachot, Bertrand, Florin, Anne, Merad, Mansouria, Scotte, Florian, Assaad, Souad, Kroemer, Guido, Blay, Jean-Yves, Marabelle, Aurélien, Griscelli, Frank, Zitvogel, Laurence, and Derosa, Lisa

Published
2021
Full Text
View/download PDF

19. Cross-tissue single-cell landscape of human monocytes and macrophages in health and disease

Author

Mulder, Kevin, Patel, Amit Ashok, Kong, Wan Ting, Piot, Cécile, Halitzki, Evelyn, Dunsmore, Garett, Khalilnezhad, Shabnam, Irac, Sergio Erdal, Dubuisson, Agathe, Chevrier, Marion, Zhang, Xiao Meng, Tam, John Kit Chung, Lim, Tony Kiat Hon, Wong, Regina Men Men, Pai, Rhea, Khalil, Ahmed Ibrahim Samir, Chow, Pierce Kah Hoe, Wu, Suny Z., Al-Eryani, Ghamdan, Roden, Daniel, Swarbrick, Alexander, Chan, Jerry Kok Yen, Albani, Salvatore, Derosa, Lisa, Zitvogel, Laurence, Sharma, Ankur, Chen, Jinmiao, Silvin, Aymeric, Bertoletti, Antonio, Blériot, Camille, Dutertre, Charles-Antoine, and Ginhoux, Florent

Published
2021
Full Text
View/download PDF

20. Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade

Author

Andrews, Miles C., Duong, Connie P. M., Gopalakrishnan, Vancheswaran, Iebba, Valerio, Chen, Wei-Shen, Derosa, Lisa, and Khan, Md Abdul Wadud

Subjects
Microbiota (Symbiotic organisms) -- Health aspects, Immunotherapy -- Complications and side effects, Melanoma -- Development and progression -- Care and treatment, Biological sciences, Health
Abstract

Treatment with combined immune checkpoint blockade (CICB) targeting CTLA-4 and PD-1 is associated with clinical benefit across tumor types, but also a high rate of immune-related adverse events. Insights into biomarkers and mechanisms of response and toxicity to CICB are needed. To address this, we profiled the blood, tumor and gut microbiome of 77 patients with advanced melanoma treated with CICB, with a high rate of any [greater than or equal to]grade 3 immune-related adverse events (49%) with parallel studies in pre-clinical models. Tumor-associated immune and genomic biomarkers of response to CICB were similar to those identified for ICB monotherapy, and toxicity from CICB was associated with a more diverse peripheral T-cell repertoire. Profiling of gut microbiota demonstrated a significantly higher abundance of Bacteroides intestinalis in patients with toxicity, with upregulation of mucosal IL-1[beta] in patient samples of colitis and in pre-clinical models. Together, these data offer potential new therapeutic angles for targeting toxicity to CICB. Clinical benefit or intestinal toxicity resulting from combined immune checkpoint blockade in patients with melanoma associates with prevalent commensal bacteria and can be decoupled by IL-1R inhibition., Author(s): Miles C. Andrews [sup.1] [sup.2] [sup.3] , Connie P. M. Duong [sup.4] [sup.5] [sup.6] , Vancheswaran Gopalakrishnan [sup.1] , Valerio Iebba [sup.4] [sup.5] , Wei-Shen Chen [sup.7] [sup.8] , [...]

Published
2021
Full Text
View/download PDF

21. Intestinal microbiota influences clinical outcome and side effects of early breast cancer treatment

Author

Terrisse, Safae, Derosa, Lisa, Iebba, Valerio, Ghiringhelli, François, Vaz-Luis, Ines, Kroemer, Guido, Fidelle, Marine, Christodoulidis, Stergios, Segata, Nicola, Thomas, Andrew Maltez, Martin, Anne-Laure, Sirven, Aude, Everhard, Sibille, Aprahamian, Fanny, Nirmalathasan, Nitharsshini, Aarnoutse, Romy, Smidt, Marjolein, Ziemons, Janine, Caldas, Carlos, Loibl, Sibylle, Denkert, Carsten, Durand, Sylvere, Iglesias, Claudia, Pietrantonio, Filippo, Routy, Bertrand, André, Fabrice, Pasolli, Edoardo, Delaloge, Suzette, and Zitvogel, Laurence

Published
2021
Full Text
View/download PDF

22. Multifaceted modes of action of the anticancer probiotic Enterococcus hirae

Author

Goubet, Anne-Gaëlle, Wheeler, Richard, Fluckiger, Aurélie, Qu, Bo, Lemaître, Fabien, Iribarren, Kristina, Mondragón, Laura, Tidjani Alou, Maryam, Pizzato, Eugénie, Durand, Sylvère, Derosa, Lisa, Aprahamian, Fanny, Bossut, Noélie, Moya-Nilges, Maryse, Derrien, Diane, Chen, Guo, Leduc, Marion, Joseph, Adrien, Pons, Nicolas, Le Chatelier, Emmanuelle, Segata, Nicola, Yonekura, Satoru, Iebba, Valerio, Kepp, Oliver, Raoult, Didier, André, Fabrice, Kroemer, Guido, Boneca, Ivo Gomperts, Zitvogel, Laurence, and Daillère, Romain

Published
2021
Full Text
View/download PDF

24. Influence of microbiota-associated metabolic reprogramming on clinical outcome in patients with melanoma from the randomized adjuvant dendritic cell-based MIND-DC trial

Author

MS Hematologie, Alves Costa Silva, Carolina, Piccinno, Gianmarco, Suissa, Déborah, Bourgin, Mélanie, Schreibelt, Gerty, Durand, Sylvère, Birebent, Roxanne, Fidelle, Marine, Sow, Cissé, Aprahamian, Fanny, Manghi, Paolo, Punčochář, Michal, Asnicar, Francesco, Pinto, Federica, Armanini, Federica, Terrisse, Safae, Routy, Bertrand, Drubay, Damien, Eggermont, Alexander M.M., Kroemer, Guido, Segata, Nicola, Zitvogel, Laurence, Derosa, Lisa, Bol, Kalijn F., de Vries, I. Jolanda M., MS Hematologie, Alves Costa Silva, Carolina, Piccinno, Gianmarco, Suissa, Déborah, Bourgin, Mélanie, Schreibelt, Gerty, Durand, Sylvère, Birebent, Roxanne, Fidelle, Marine, Sow, Cissé, Aprahamian, Fanny, Manghi, Paolo, Punčochář, Michal, Asnicar, Francesco, Pinto, Federica, Armanini, Federica, Terrisse, Safae, Routy, Bertrand, Drubay, Damien, Eggermont, Alexander M.M., Kroemer, Guido, Segata, Nicola, Zitvogel, Laurence, Derosa, Lisa, Bol, Kalijn F., and de Vries, I. Jolanda M.

Published
2024

25. State of the art and the future of microbiome-based biomarkers:a multidisciplinary Delphi consensus

Author

Rodriguez, Julie, Hassani, Zahra, Alves Costa Silva, Carolina, Betsou, Fay, Carraturo, Federica, Fasano, Alessio, Israelsen, Mads, Iyappan, Anandhi, Krag, Aleksander, Metwaly, Amira, Schierwagen, Robert, Trebicka, Jonel, Zwart, Hub, Doré, Joel, Cordaillat-Simmons, Magali, Druart, Celine, Godoy, Yolanda, Bork, Peer, Typas, Nassos, Hazenbrink, Dienty Hendrina Maria Johanna, Zitvogel, Laurence, Derosa, Lisa, Blottière, Hervé, Kriaa, Aicha, Maguin, Emmanuelle, Rhimi, Moez, Veiga, Patrick, Pons, Nicolas, Prost, Pierre Louis, Jarde, Alexander, Boutron, Isabelle, Ravaud, Philippe, Falk Villesen, Ida, Haller, Dirk, Ross, Paul, O'Toole, Paul, Lavelle, Aonghus, Claesson, Marcus, Joos, Raphaela, Hill, Colin, Shkoporov, Andrey, Loftus, Saba, Boucher, Katy, Arumugam, Manimozhayan, Sarathi, Arjun, Morozova, Vitalina, Segata, Nicola, Asnicar, Francesco, Pinto, Federica, Rodriguez, Julie, Hassani, Zahra, Alves Costa Silva, Carolina, Betsou, Fay, Carraturo, Federica, Fasano, Alessio, Israelsen, Mads, Iyappan, Anandhi, Krag, Aleksander, Metwaly, Amira, Schierwagen, Robert, Trebicka, Jonel, Zwart, Hub, Doré, Joel, Cordaillat-Simmons, Magali, Druart, Celine, Godoy, Yolanda, Bork, Peer, Typas, Nassos, Hazenbrink, Dienty Hendrina Maria Johanna, Zitvogel, Laurence, Derosa, Lisa, Blottière, Hervé, Kriaa, Aicha, Maguin, Emmanuelle, Rhimi, Moez, Veiga, Patrick, Pons, Nicolas, Prost, Pierre Louis, Jarde, Alexander, Boutron, Isabelle, Ravaud, Philippe, Falk Villesen, Ida, Haller, Dirk, Ross, Paul, O'Toole, Paul, Lavelle, Aonghus, Claesson, Marcus, Joos, Raphaela, Hill, Colin, Shkoporov, Andrey, Loftus, Saba, Boucher, Katy, Arumugam, Manimozhayan, Sarathi, Arjun, Morozova, Vitalina, Segata, Nicola, Asnicar, Francesco, and Pinto, Federica

Abstract

Although microbiome signatures have been identified in various contexts (ie, pathogenesis of non-communicable diseases and treatment response), qualified microbiome-based biomarkers are currently not in use in clinical practice. The Human Microbiome Action consortium initiated a Delphi survey to establish a consensus on the needs, challenges, and limitations in developing qualified microbiome-based biomarkers. The questionnaire was developed by a scientific committee via literature review and expert interviews. To ensure broad applicability of the results, 307 experts were invited to participate; 114 of them responded to the first round of the survey, 93 of whom completed the second and final round as well. The survey highlighted the experts’ confidence in the potential of microbiome-based biomarkers for several indications or pathologies. The paucity of validated analytical methods appears to be the principal factor hindering the qualification of these biomarkers. The survey also showed that clinical implementation of these biomarkers would only be possible if kitted and validated molecular assays with simple interpretation are developed. This initiative serves as a foundation for designing and implementing public-private collaborative projects to overcome the challenges and promote clinical application of microbiome-based biomarkers.

Published
2024

27. Characterizing the immune tumor microenvironment in ALK fusion-positive lung cancer: state-of-the-art and therapeutical implications.

Author

Sposito, Marco, Eccher, Serena, Pasqualin, Luca, Scaglione, Ilaria Mariangela, Avancini, Alice, Tregnago, Daniela, Trestini, Ilaria, Insolda, Jessica, Bonato, Adele, Ugel, Stefano, Derosa, Lisa, Milella, Michele, Pilotto, Sara, and Belluomini, Lorenzo

Subjects
LUNG cancer, TUMOR microenvironment, ANAPLASTIC lymphoma kinase, NON-small-cell lung carcinoma
Abstract

Approximately 5% of non-small cell lung cancer (NSCLC), exhibits anaplastic lymphoma kinase (ALK) rearrangements. EML4-ALK fusions account for over 90% of ALK rearrangements in NSCLC. The advent of treatment targeting ALK has significantly improved survival rates in patients with advanced ALK-positive NSCLC. However, the emergence of resistance mechanisms and the subsequent progression disease inevitably occurs. The tumor immune microenvironment (TIME) plays a pivotal role in lung cancer, influencing disease development, patient's outcomes, and response to treatments. The aim of this review is to provide a comprehensive characterization of the TIME in ALK rearranged NSCLC and its intrinsic plasticity under treatment pressure. Recognizing the fundamental role of the TIME in cancer progression has shifted the paradigm from a tumor cell-centric perspective to the understanding of a complex tumor ecosystem. Understanding the intricate dynamics of the TIME, its influence on treatment response, and the potential of immunotherapy in patients with ALK-positive NSCLC are currently among the primary research objectives in this patient population. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

28. Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19

Author

Silvin, Aymeric, Chapuis, Nicolas, Dunsmore, Garett, Goubet, Anne-Gaëlle, Dubuisson, Agathe, Derosa, Lisa, Almire, Carole, Hénon, Clémence, Kosmider, Olivier, Droin, Nathalie, Rameau, Philippe, Catelain, Cyril, Alfaro, Alexia, Dussiau, Charles, Friedrich, Chloé, Sourdeau, Elise, Marin, Nathalie, Szwebel, Tali-Anne, Cantin, Delphine, Mouthon, Luc, Borderie, Didier, Deloger, Marc, Bredel, Delphine, Mouraud, Severine, Drubay, Damien, Andrieu, Muriel, Lhonneur, Anne-Sophie, Saada, Véronique, Stoclin, Annabelle, Willekens, Christophe, Pommeret, Fanny, Griscelli, Frank, Ng, Lai Guan, Zhang, Zheng, Bost, Pierre, Amit, Ido, Barlesi, Fabrice, Marabelle, Aurélien, Pène, Frédéric, Gachot, Bertrand, André, Fabrice, Zitvogel, Laurence, Ginhoux, Florent, Fontenay, Michaela, and Solary, Eric

Published
2020
Full Text
View/download PDF

29. Gut Bacteria Composition Drives Primary Resistance to Cancer Immunotherapy in Renal Cell Carcinoma Patients

Author

Derosa, Lisa, Routy, Bertrand, Fidelle, Marine, Iebba, Valerio, Alla, Laurie, Pasolli, Edoardo, Segata, Nicola, Desnoyer, Aude, Pietrantonio, Filippo, Ferrere, Gladys, Fahrner, Jean-Eudes, Le Chatellier, Emmanuelle, Pons, Nicolas, Galleron, Nathalie, Roume, Hugo, Duong, Connie P.M., Mondragón, Laura, Iribarren, Kristina, Bonvalet, Mélodie, Terrisse, Safae, Rauber, Conrad, Goubet, Anne-Gaëlle, Daillère, Romain, Lemaitre, Fabien, Reni, Anna, Casu, Beatrice, Alou, Maryam Tidjani, Alves Costa Silva, Carolina, Raoult, Didier, Fizazi, Karim, Escudier, Bernard, Kroemer, Guido, Albiges, Laurence, and Zitvogel, Laurence

Published
2020
Full Text
View/download PDF

30. On-target Toxicities Predictive of Survival in Metastatic Renal Cell Carcinoma (mRCC) Treated With Sunitinib: A Multicenter Retrospective Study

Author

Bolzacchini, Elena, Pinotti, Graziella, Bertù, Lorenza, Verusio, Claudio, Galli, Luca, Mumoli, Nicola, Barbara, Cecilia, Danova, Marco, Bregni, Marco, Artale, Salvatore, Rossini, Chiara, Nigro, Olga, Antonuzzo, Andrea, Derosa, Lisa, Torchio, Martina, Barzaghi, Sabrina, Ricci, Isabella, Suter, Matteo, Ballerio, Alice, Vallini, Ilaria, and Dentali, Francesco

Published
2020
Full Text
View/download PDF

33. Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer

Author

Roberti, Maria Paula, Yonekura, Satoru, Duong, Connie P. M., Picard, Marion, Ferrere, Gladys, Tidjani Alou, Maryam, Rauber, Conrad, Iebba, Valerio, Lehmann, Christian H. K., Amon, Lukas, Dudziak, Diana, Derosa, Lisa, Routy, Bertrand, Flament, Caroline, Richard, Corentin, Daillère, Romain, Fluckiger, Aurélie, Van Seuningen, Isabelle, Chamaillard, Mathias, Vincent, Audrey, Kourula, Stephanie, Opolon, Paule, Ly, Pierre, Pizzato, Eugénie, Becharef, Sonia, Paillet, Juliette, Klein, Christophe, Marliot, Florence, Pietrantonio, Filippo, Benoist, Stéphane, Scoazec, Jean-Yves, Dartigues, Peggy, Hollebecque, Antoine, Malka, David, Pagès, Franck, Galon, Jérôme, Gomperts Boneca, Ivo, Lepage, Patricia, Ryffel, Bernard, Raoult, Didier, Eggermont, Alexander, Vanden Berghe, Tom, Ghiringhelli, François, Vandenabeele, Peter, Kroemer, Guido, and Zitvogel, Laurence

Published
2020
Full Text
View/download PDF

37. 1510 Multiomic functional biomarkers for cancer prediction and early detection

Author

Fidelle, Marine, primary, Suissa, Deborah, additional, Birebent, Roxanne, additional, Ben-Ahmed, Tarek, additional, de la Varende, Anne-Laure Mallard, additional, Costa Silva, Carolina Alves, additional, Blampey, Quentin, additional, Silvin, Aymeric, additional, Dutertre, Charles-Antoine, additional, Durand, Sylvere, additional, Chen, Hui, additional, Caron, Olivier, additional, Mercier, Olaf, additional, Derosa, Lisa, additional, Kroemer, Guido, additional, Renneville, Aline, additional, Drubay, Damien, additional, Delaloge, Suzette, additional, Boulate, David, additional, and Zitvogel, Laurence, additional

Published
2023
Full Text
View/download PDF

38. Longitudinal gut microbiome changes in immune checkpoint blockade in advanced melanoma

Author

Björk, Johannes, primary, Bolte, Laura, additional, Thomas, Andrew, additional, Lee, Karla, additional, Rossi, Niccolò, additional, Wind, Thijs, additional, Smit, Lotte, additional, Armanini, Federica, additional, Asnicar, Francesco, additional, Blanco-Míguez, Aitor, additional, Board, Ruth, additional, Llopart, Neus, additional, Derosa, Lisa, additional, Dhomen, Nathalie, additional, Brooks, Kelly, additional, Harland, Mark, additional, Harries, Mark, additional, Lorigan, Paul, additional, Manghi, Paolo, additional, Marais, Richard, additional, Newton-Bishop, Julia, additional, Nezi, Luigi, additional, Pinto, Federica, additional, Potrony, Miriam, additional, Puig, Susana, additional, Serra-Bellver, Patricio, additional, Shaw, Heather, additional, Tamburini, Sabrina, additional, Valpione, Sara, additional, Waldron, Levi, additional, ZITVOGEL, Laurence, additional, Zolfo, Moreno, additional, de Vries, Elisabeth, additional, Nathan, Paul, additional, Fehrmann, Rudolf, additional, Spector, Tim, additional, Bataille, Veronique, additional, Segata, Nicola, additional, Hospers, Geke, additional, and Weersma, Rinse, additional

Published
2023
Full Text
View/download PDF

39. Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors

Author

Routy, Bertrand, Le Chatelier, Emmanuelle, Derosa, Lisa, Duong, Connie P. M., Alou, Maryam Tidjani, Daillère, Romain, Fluckiger, Aurélie, Messaoudene, Meriem, Rauber, Conrad, Roberti, Maria P., Fidelle, Marine, Flament, Caroline, Poirier-Colame, Vichnou, Opolon, Paule, Klein, Christophe, Iribarren, Kristina, Mondragón, Laura, Jacquelot, Nicolas, Qu, Bo, Ferrere, Gladys, Clémenson, Céline, Mezquita, Laura, Masip, Jordi Remon, Naltet, Charles, Brosseau, Solenn, Kaderbhai, Coureche, Richard, Corentin, Rizvi, Hira, Levenez, Florence, Galleron, Nathalie, Quinquis, Benoit, Pons, Nicolas, Ryffel, Bernhard, Minard-Colin, Véronique, Gonin, Patrick, Soria, Jean-Charles, Deutsch, Eric, Loriot, Yohann, Ghiringhelli, François, Zalcman, Gérard, Goldwasser, François, Escudier, Bernard, Hellmann, Matthew D., Eggermont, Alexander, Raoult, Didier, Albiges, Laurence, Kroemer, Guido, and Zitvogel, Laurence

Published
2018

46. Metabolomic analyses of COVID-19 patients unravel stage-dependent and prognostic biomarkers

Author

Danlos, François-Xavier, Grajeda-Iglesias, Claudia, Durand, Sylvère, Sauvat, Allan, Roumier, Mathilde, Cantin, Delphine, Colomba, Emeline, Rohmer, Julien, Pommeret, Fanny, Baciarello, Giulia, Willekens, Christophe, Vasse, Marc, Griscelli, Frank, Fahrner, Jean-Eudes, Goubet, Anne-Gaëlle, Dubuisson, Agathe, Derosa, Lisa, Nirmalathasan, Nitharsshini, Bredel, Delphine, Mouraud, Séverine, Pradon, Caroline, Stoclin, Annabelle, Rozenberg, Flore, Duchemin, Jérôme, Jourdi, Georges, Ellouze, Syrine, Levavasseur, Françoise, Albigès, Laurence, Soria, Jean-Charles, Barlesi, Fabrice, Solary, Eric, André, Fabrice, Pène, Frédéric, Ackerman, Félix, Mouthon, Luc, Zitvogel, Laurence, Marabelle, Aurélien, Michot, Jean-Marie, Fontenay, Michaela, and Kroemer, Guido

Published
2021
Full Text
View/download PDF

47. Immunodynamics of explanted human tumors for immuno‐oncology

Author

Dubuisson, Agathe, Fahrner, Jean‐Eudes, Goubet, Anne‐Gaëlle, Terrisse, Safae, Voisin, Nicolas, Bayard, Charles, Lofek, Sebastien, Drubay, Damien, Bredel, Delphine, Mouraud, Séverine, Susini, Sandrine, Cogdill, Alexandria, Rebuffet, Lucas, Ballot, Elise, Jacquelot, Nicolas, Thomas de Montpreville, Vincent, Casiraghi, Odile, Radulescu, Camélia, Ferlicot, Sophie, Figueroa, David J, Yadavilli, Sapna, Waight, Jeremy D, Ballas, Marc, Hoos, Axel, Condamine, Thomas, Parier, Bastien, Gaudillat, Christophe, Routy, Bertrand, Ghiringhelli, François, Derosa, Lisa, Breuskin, Ingrid, Rouanne, Mathieu, André, Fabrice, Lebacle, Cédric, Baumert, Hervé, Wislez, Marie, Fadel, Elie, Cremer, Isabelle, Albiges, Laurence, Geoerger, Birgit, Scoazec, Jean‐Yves, Loriot, Yohann, Kroemer, Guido, Marabelle, Aurélien, Bonvalet, Mélodie, and Zitvogel, Laurence

Published
2021
Full Text
View/download PDF

50. Metastatic chromophobe renal cell carcinoma treated with targeted therapies: A Renal Cross Channel Group study

Author

Colomba, Emeline, Le Teuff, Gwénaël, Eisen, Tim, Stewart, Grant D., Fife, Kate, Larkin, James, Biondo, Andrea, Pickering, Lisa, Srinivasan, Anandagopal, Boyle, Helen, Derosa, Lisa, Sternberg, Cora N., Recine, Federica, Ralph, Christy, Saldana, Carolina, Barthélémy, Philippe, Bernhard, Jean Christophe, Gurney, Howard, Verhoest, Gregory, Vauleon, Elodie, Bigot, Pierre, Berger, Julien, Pfister, Christian, Gravis, Gwenaelle, Rodier, Jean-Michel, Culine, Stéphane, Caty, Armelle, Rolland, Frederic, Priou, Franck, Escudier, Bernard, and Albiges, Laurence

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results