Search

Your search keyword '"Dernis, Emmanuelle"' showing total 378 results
Start Over Author "Dernis, Emmanuelle"
378 results on '"Dernis, Emmanuelle"'

1. 2024 update of the recommendations of the French Society of Rheumatology for the diagnosis and management of patients with rheumatoid arthritis

Author

Fautrel, Bruno, Kedra, Joanna, Rempenault, Claire, Juge, Pierre-Antoine, Drouet, Juliette, Avouac, Jérôme, Baillet, Athan, Brocq, Olivier, Alegria, Guillermo Carvajal, Constantin, Arnaud, Dernis, Emmanuelle, Gaujoux-Viala, Cécile, Goëb, Vincent, Gottenberg, Jacques-Eric, Le Goff, Benoit, Marotte, Hubert, Richez, Christophe, Salmon, Jean-Hugues, Saraux, Alain, Senbel, Eric, Seror, Raphaèle, Tournadre, Anne, Vittecoq, Olivier, Escaffre, Pascale, Vacher, Danielle, Dieudé, Philippe, and Daien, Claire

Published
2024
Full Text
View/download PDF

2. Actualisation 2024 des recommandations de la Société française de rhumatologie pour le diagnostic et la prise en charge des personnes souffrant de polyarthrite rhumatoïde

Author

Fautrel, Bruno, Kedra, Joanna, Rempenault, Claire, Juge, Pierre-Antoine, Drouet, Juliette, Avouac, Jérôme, Baillet, Athan, Brocq, Olivier, Alegria, Guillermo Carvajal, Constantin, Arnaud, Dernis, Emmanuelle, Gaujoux-Viala, Cécile, Goëb, Vincent, Gottenberg, Jacques-Eric, Le Goff, Benoit, Marotte, Hubert, Richez, Christophe, Salmon, Jean-Hugues, Saraux, Alain, Senbel, Eric, Seror, Raphaèle, Tournadre, Anne, Vittecoq, Olivier, Escaffre, Pascale, Vacher, Danielle, Dieudé, Philippe, and Daien, Claire

Published
2024
Full Text
View/download PDF

3. Recommandations de la Société française de rhumatologie pour la prise en charge en pratique courante des patients atteints de pseudopolyarthrite rhizomélique

Author

Wendling, Daniel, Al Tabaa, Omar, Chevet, Baptiste, Fakih, Olivier, Ghossan, Roba, Hecquet, Sophie, Dernis, Emmanuelle, Maheu, Emmanuel, Saraux, Alain, Besson, Florent L., Carvajal Alegria, Guillermo, Cortet, Bernard, Fautrel, Bruno, Felten, Renaud, Morel, Jacques, Ottaviani, Sébastien, Querellou-Lefranc, Solène, Ramon, André, Ruyssen-Witrand, Adeline, Seror, Raphaèle, Tournadre, Anne, Foulquier, Nathan, Verlhac, Bernard, Verhoeven, Frank, and Devauchelle-Pensec, Valérie

Published
2024
Full Text
View/download PDF

4. Unmet needs in axial spondyloarthritis. Proceedings of the French spondyloarthritis taskforce workshop

Author

Wendling, Daniel, Breban, Maxime, Costantino, Félicie, Lequerré, Thierry, Felten, Renaud, Ruyssen-Witrand, Adeline, Tournadre, Anne, Vegas, Laura Pina, Marotte, Hubert, Baillet, Athan, Loeuille, Damien, Lukas, Cédric, Miceli-Richard, Corinne, Gossec, Laure, Molto, Anna, Goupille, Philippe, Pham, Thao, Dernis, Emmanuelle, Claudepierre, Pascal, Verhoeven, Frank, and Prati, Clément

Published
2024
Full Text
View/download PDF

5. Standardized reporting for systematic global evaluation of axial spondyloarthritis: An evidence-based and consensus-driven initiative

Author

Ruyssen-Witrand, Adeline, Caillet-Portillo, Damien, Najm, Aurélie, Fogel, Olivier, Baillet, Athan, Claudepierre, Pascal, Conort, Orenella, Dernis, Emmanuelle, Fayet, Françoise, Gossec, Laure, Goupille, Philippe, Hudry, Christophe, Letarouilly, Jean-Guillaume, Lukas, Cédric, Marotte, Hubert, Molto, Anna, Pouplin, Sophie, Senbel, Eric, Sordet, Christelle, Tournadre, Anne, Truchetet, Marie-Elise, Wendling, Daniel, and Dougados, Maxime

Published
2024
Full Text
View/download PDF

6. Recommendations of the French Society of Rheumatology for the management in current practice of patients with polymyalgia rheumatica

Author

Wendling, Daniel, Al Tabaa, Omar, Chevet, Baptiste, Fakih, Olivier, Ghossan, Roba, Hecquet, Sophie, Dernis, Emmanuelle, Maheu, Emmanuel, Saraux, Alain, Besson, Florent L., Alegria, Guillermo Carvajal, Cortet, Bernard, Fautrel, Bruno, Felten, Renaud, Morel, Jacques, Ottaviani, Sébastien, Querellou-Lefranc, Solène, Ramon, André, Ruyssen-Witrand, Adeline, Seror, Raphaèle, Tournadre, Anne, Foulquier, Nathan, Verlhac, Bernard, Verhoeven, Frank, and Devauchelle-Pensec, Valérie

Published
2024
Full Text
View/download PDF

7. Identification of distinct subgroups of Sjögren's disease by cluster analysis based on clinical and biological manifestations: data from the cross-sectional Paris-Saclay and the prospective ASSESS cohorts

Author

Nguyen, Yann, Nocturne, Gaëtane, Henry, Julien, Ng, Wan-Fai, Belkhir, Rakiba, Desmoulins, Frédéric, Bergé, Elisabeth, Morel, Jacques, Perdriger, Aleth, Dernis, Emmanuelle, Devauchelle-Pensec, Valérie, Sène, Damien, Dieudé, Philippe, Couderc, Marion, Fauchais, Anne-Laure, Larroche, Claire, Vittecoq, Olivier, Salliot, Carine, Hachulla, Eric, Le Guern, Véronique, Gottenberg, Jacques-Eric, Mariette, Xavier, and Seror, Raphaèle

Published
2024
Full Text
View/download PDF

9. Évaluation globale standardisée systématique des rhumatismes inflammatoires chroniques : intérêts et limites

Author

Fogel, Olivier, Caillet-Portillo, Damien, Najm, Aurélie, Baillet, Athan, Claudepierre, Pascal, Conort, Ornella, Dernis, Emmanuelle, Fayet, Françoise, Gossec, Laure, Goupille, Philippe, Hudry, Christophe, Letarouilly, Jean-Guillaume, Lukas, Cédric, Marotte, Hubert, Molto, Anna, Pouplin, Sophie, Senbel, Eric, Sordet, Christelle, Tournadre, Anne, Truchetet, Marie-Elise, Wendling, Daniel, Ruyssen-Witrand, Adeline, and Dougados, Maxime

Published
2024
Full Text
View/download PDF

10. Pregnancy outcomes in women with primary Sjögren's syndrome: an analysis of data from the multicentre, prospective, GR2 study

Author

AUDEMARD-VERGER, Alexandra, AZZI, Emmanuel, BANNEVILLE, Béatrice, BAUDET, Antoine, BEAUDOUIN BAZIRE, Constance, BELIZNA, Cristina, Belot, Alexandre, BENHAMOU, Ygal, Berezné, Alice, BERNARD-GUERVILLY, Fanny, BERTHIER, Sabine, BEZANAHARY, Holy, BIALE, Lisa, BIGOT, Adrien, BLANCHARD-DELAUNAY, Claire, CALAS, Anne, CAMPAGNE, Julien, CATHEBRAS, Pascal, CAZALETS, Claire, CHAIGNE, Benjamin, CHANDESRIS, Olivia, CHATELAIS, Jérémy, CHATELUS, Emmanuel, COHEN, Fleur, Combe, Bernard, COMPARON, Céline, COQUERELLE, Pascal, DAMIAN, Louise, DAUGAS, Eric, DE MENTHON, Mathilde, DE MOREUIL, Claire, DELATTRE, Estelle, DELLAL, Azeddine, Deneux-Tharaux, Catherine, DENIS, Amélie, DEPROUW, Camille, DERNIS, Emmanuelle, DEROUX, Alban, DESOUCHES, Sandra, Dieudé, Philippe, DIREZ, Guillaume, Dougados, Maxime, DRIESSEN, Marine, DU THANH, Aurélie, DUNOGEANT, Laetitia, DURANT, Cécile, DUREL, Cécile-Audrey, DURIEU, Isabelle, EBOUE, Florence, Elefant, Elisabeth, FAIN, Olivier, FAUTREL, Bruno, FLIPO, René-Marc, FRAZIER, Aline, FROISSART, Antoine, GEORGIN-LAVIALLE, Sophie, GERVAIS, Elisabeth, GODEAU, Bertrand, Goffinet, François, GOMPEL, Anne, GOSSEC, Laure, GOUPILLE, Philippe, GRANGE, Claire, GUILLAUD-DANIS, Constance, HACHULLA, Eric, HOEFSLOOT, Sabine, HUMMEL, Aurélie, JEGO, Patrick, JOBARD, Stéphanie, JOSSELIN-MAHR, Laurence, LAMBERT, Marc, LANGLOIS, Vincent, LARIVIERE, Delphine, LARROCHE, Claire, LATOURTE, Augustin, LAVIGNE, Christian, LE GALLOU, Thomas, LEROUX, Gaëlle, LETAROUILLY, Jean Guillaume, LIOTÉ, Frédéric, Loeuillet, Laurence, London, Jonathan, Loustau, Valentine, LOZAC'H, Pierre, MAHEU, Emmanuel, MAILLARD, Hélène, MAROTTE, Hubert, MASSEAU, Agathe, MEKINIAN, Arsène, Melboucy Belkhir, Sara, Miceli-Richard, Corinne, MICHAUD, Martin, MICHEL, Marc, MORANNE, Olivier, MORATI-HAFSAOUI, Chafika, MOULIS, Guillaume, MOUTHON, Luc, NICOLAS, Barbara, Nizard, Jacky, ORA, Jérémy, OUTH, Rodérau, PASQUIER, Elisabeth, PENNAFORTE, Jean-Loup, PERLAT, Antoinette, PETIT-BAUER, Hélène, PILLEBOUT, Evangeline, PIOT, Jean-Maxime, PORTIER, Agnès, Pourrat, Olivier, PUECHAL, Xavier, PUGNET, Gregory, REDONDIN, Manon, REGENT, Alexis, RORIZ, Mélanie, SAILLER, Laurent, SAVEY, Léa, SCHERLINGER, Marc, SCHLEINITZ, Nicolas, Sellam, Jérémie, Sentilhes, Loïc, SERVAIS, Aude, SMETS, Perrine, SORDET, Christelle, SOUBRIER, Martin, STANKOVIC-STOJANOVIC, Katia, URBANSKI, Geoffrey, VEIT, Véronique, WEBER, Emmanuelle, YELNIK, Cécile, de Frémont, Grégoire Martin, Costedoat-Chalumeau, Nathalie, Lazaro, Estibaliz, Belkhir, Rakiba, Guettrot-Imbert, Gaëlle, Morel, Nathalie, Nocturne, Gaétane, Molto, Anna, Goulenok, Tiphaine, Diot, Elisabeth, Perard, Laurent, Ferreira-Maldent, Nicole, Le Besnerais, Maelle, Limal, Nicolas, Martis, Nihal, Abisror, Noémie, Debouverie, Odile, Richez, Christophe, Sobanski, Vincent, Maurier, François, Sauvetre, Gaëtan, Levesque, Hervé, Timsit, Marie-Agnès, Tieulié, Nathalie, Orquevaux, Pauline, Bienvenu, Boris, Mahevas, Matthieu, Papo, Thomas, Lartigau-Roussin, Céline, Chauvet, Elodie, Berthoux, Emilie, Sarrot-Reynauld, Françoise, Raffray, Loïc, Couderc, Marion, Silva, Nicolas Martin, Jourde-Chiche, Noémie, Belhomme, Nicolas, Thomas, Thierry, Poindron, Vincent, Queyrel-Moranne, Viviane, Delforge, Juliette, Le Ray, Camille, Pannier, Emmanuelle, Mariette, Xavier, Le Guern, Véronique, and Seror, Raphaèle

Published
2023
Full Text
View/download PDF

11. Patient-defined flares and disease activity worsening in 222 patients with psoriatic arthritis from 14 countries

Author

Sousa, Marlene, Lubrano, Ennio, Smolen, Josef S., Gorlier, Clémence, de Wit, Maarten, Coates, Laura C., Kalyoncu, Umut, Ruyssen-Witrand, Adeline, Leung, Ying-Ying, Scrivo, Rossana, Cañete, Juan D., Palominos, Penelope, Meisalu, Sandra, Balanescu, Andra, Kiltz, Uta, Aydin, Sibel Zehra, Gaydukova, Inna, Dernis, Emmanuelle, Fautrel, Bruno, Orbai, Ana-Maria, and Gossec, Laure

Published
2023
Full Text
View/download PDF

12. 2022 French Society for Rheumatology (SFR) recommendations on the everyday management of patients with spondyloarthritis, including psoriatic arthritis

Author

Wendling, Daniel, Hecquet, Sophie, Fogel, Olivier, Letarouilly, Jean-Guillaume, Verhoeven, Frank, Pham, Thao, Prati, Clément, Molto, Anna, Goupille, Philippe, Dernis, Emmanuelle, Saraux, Alain, Ruyssen-Witrand, Adeline, Lukas, Cédric, Miceli-Richard, Corinne, Hudry, Christophe, Richette, Pascal, Breban, Maxime, Gossec, Laure, Dougados, Maxime, and Claudepierre, Pascal

Published
2022
Full Text
View/download PDF

13. Actualisation 2022 des recommandations de la Société française de rhumatologie (SFR) pour la prise en charge en pratique courante des malades atteints de spondyloarthrite, incluant le rhumatisme psoriasique

Author

Wendling, Daniel, Hecquet, Sophie, Fogel, Olivier, Letarouilly, Jean-Guillaume, Verhoeven, Frank, Pham, Thao, Prati, Clément, Molto, Anna, Goupille, Philippe, Dernis, Emmanuelle, Saraux, Alain, Ruyssen-Witrand, Adeline, Lukas, Cédric, Miceli-Richard, Corinne, Hudry, Christophe, Richette, Pascal, Breban, Maxime, Gossec, Laure, Dougados, Maxime, and Claudepierre, Pascal

Published
2022
Full Text
View/download PDF

14. An international multicentre analysis of current prescribing practices and shared decision-making in psoriatic arthritis.

Author

Watson, Lily, Coyle, Conor, Whately-Smith, Caroline, Brooke, Melanie, Kiltz, Uta, Lubrano, Ennio, Queiro, Rubén, Trigos, David, Brandt-Juergens, Jan, Choy, Ernest, D'Angelo, Salvatore, Sedie, Andrea Delle, Dernis, Emmanuelle, Guis, Sandrine, Helliwell, Philip, Ho, Pauline, Hueber, Axel J, Joven, Beatriz, Koehm, Michaela, and Montilla, Carlos

Abstract

Objectives Shared decision-making (SDM) is advocated to improve patient outcomes in PsA. We analysed current prescribing practices and the extent of SDM in PsA across Europe. Methods The ASSIST study was a cross-sectional observational study of PsA patients ≥18 years of age attending face-to-face appointments between July 2021 and March 2022. Patient demographics, current treatment and treatment decisions were recorded. SDM was measured by the clinician's effort to collaborate (CollaboRATE questionnaire) and patient communication confidence (PEPPI-5 tool). Results A total of 503 patients were included from 24 centres across the UK, France, Germany, Italy and Spain. Physician- and patient-reported measures of disease activity were highest in the UK. Conventional synthetic DMARDs constituted a higher percentage of current PsA treatment in the UK than continental Europe (66.4% vs 44.9%), which differed from biologic DMARDs (36.4% vs 64.4%). Implementing treatment escalation was most common in the UK. CollaboRATE and PEPPI-5 scores were high across centres. Of 31 patients with low CollaboRATE scores (<4.5), no patients with low PsAID-12 scores (<5) had treatment escalation. However, of 465 patients with CollaboRATE scores ≥4.5, 59 patients with low PsAID-12 scores received treatment escalation. Conclusions Higher rates of treatment escalation seen in the UK may be explained by higher disease activity and a younger cohort. High levels of collaboration in face-to-face PsA consultations suggests effective implementation of the SDM approach. Our data indicate that in patients with mild disease activity, only those with higher perceived collaboration underwent treatment escalation. Prospective studies should examine the impact of SDM on PsA patient outcomes. Trial registration clinicaltrials.gov , NCT05171270. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

15. Recommandations de la Société Française de Rhumatologie pour la prise en charge en pratique courante des patients atteints de Pseudo Polyarthrite Rhizomélique

Author

Wendling, Daniel, primary, Tabaa, Omar Al, additional, Chevet, Baptiste, additional, Fakih, Olivier, additional, Ghossan, Roba, additional, Hecquet, Sophie, additional, Dernis, Emmanuelle, additional, Maheu, Emmanuel, additional, Saraux, Alain, additional, Besson, Florent L., additional, Alegria, Guillermo Carvajal, additional, Cortet, Bernard, additional, Fautrel, Bruno, additional, Felten, Renaud, additional, Morel, Jacques, additional, Ottaviani, Sébastien, additional, Querellou-Lefranc, Solène, additional, Ramon, André, additional, Ruyssen-Witrand, Adeline, additional, Seror, Raphaèle, additional, Tournadre, Anne, additional, Foulquier, Nathan, additional, Verlhac, Bernard, additional, Verhoeven, Frank, additional, and Devauchelle-Pensec, Valérie, additional

Published
2024
Full Text
View/download PDF

16. Points to consider for unmet needs in axial spondyloarthritis. Proceedings of the French spondyloArthritiS Taskforce workshop

Author

Wendling, Daniel, primary, Breban, Maxime, additional, Costantino, Félicie, additional, Lequerré, Thierry, additional, Felten, Renaud, additional, Ruyssen-Witrand, Adeline, additional, Tournadre, Anne, additional, Vegas, Laura Pina, additional, Marotte, Hubert, additional, Baillet, Athan, additional, Loeuille, Damien, additional, Lukas, Cédric, additional, Miceli-Richard, Corinne, additional, Gossec, Laure, additional, Molto, Anna, additional, Goupille, Philippe, additional, Pham, Thao, additional, Dernis, Emmanuelle, additional, Claudepierre, Pascal, additional, Verhoeven, Frank, additional, and Prati, Clément, additional

Published
2024
Full Text
View/download PDF

17. Les déterminants des troubles du sommeil dans le rhumatisme psoriasique : étude observationnelle portant sur 696 patients de 14 pays

Author

Palominos, Penélope Esther, Coates, Laura, Kohem, Charles Lubianca, Orbai, Ana-Maria, Smolen, Josef, de Wit, Maarten, Kiltz, Uta, Leung, Ying-Ying, Cañete, Juan D., Scrivo, Rossana, Balanescu, Andra, Dernis, Emmanuelle, Meisalu, Sandra, Soubrier, Martin, Aydin, Sibel Zehra, Gaydukova, Inna, Kalyoncu, Umut, and Gossec, Laure

Published
2021
Full Text
View/download PDF

21. How do patient-reported outcome measures affect treatment intensification and patient satisfaction in the management of psoriatic arthritis? A cross sectional study of 503 patients

Author

Coyle, Conor, primary, Watson, Lily, additional, Whately-Smith, Caroline, additional, Brooke, Mel, additional, Kiltz, Uta, additional, Lubrano, Ennio, additional, Queiro, Ruben, additional, Trigos, David, additional, Brandt-Juergens, Jan, additional, Choy, Ernest, additional, D’Angelo, Salvatore, additional, Delle Sedie, Andrea, additional, Dernis, Emmanuelle, additional, Wirth, Théo, additional, Guis, Sandrine, additional, Helliwell, Philip, additional, Ho, Pauline, additional, Hueber, Axel, additional, Joven, Beatriz, additional, Koehm, Michaela, additional, Morales, Carlos Montilla, additional, Packham, Jon, additional, Pinto Tasende, Jose Antonio, additional, Ramírez, Julio, additional, Ruyssen-Witrand, Adeline, additional, Scrivo, Rossana, additional, Twigg, Sarah, additional, Welcker, Martin, additional, Soubrier, Martin, additional, Gossec, Laure, additional, and Coates, Laura C, additional

Published
2024
Full Text
View/download PDF

22. Échographie et détection des anomalies infracliniques articulaires et tendineuses chez des patients atteints de lupus érythémateux systémique (LES) : étude transversale multicentrique

Author

Salliot, Carine, Denis, Amélie, Dernis, Emmanuelle, Andre, Vincent, Perdriger, Aleth, Albert, Jean-David, Mraghni, Saloua Mammou, Griffoul-Espitalier, Isabelle, Hamidou, Mohamed, Le Goff, Benoit, Joulin, Sandrine Jousse, Marhadour, Thierry, Richez, Christophe, Poursac, Nicolas, Lazaro, Estebaliz, Rist, Stéphanie, Corondan, Anca, Quinten, Clara, Martaillé, Virginie, Valéry, Antoine, and Ducourau, Emilie

Published
2019
Full Text
View/download PDF

24. Towards the Lowest Efficacious Dose: Results From a Multicenter Noninferiority Randomized Open‐Label Controlled Trial Assessing Tocilizumab or Abatacept Injection Spacing in Rheumatoid Arthritis in Remission.

Author

Kedra, Joanna, Dieudé, Philippe, Giboin, Caroline, Marotte, Hubert, Salliot, Carine, Schaeverbeke, Thierry, Perdriger, Aleth, Soubrier, Martin, Morel, Jacques, Constantin, Arnaud, Dernis, Emmanuelle, Royant, Valérie, Salmon, Jean‐Hugues, Pham, Thao, Gottenberg, Jacques‐Eric, Pertuiset, Edouard, Dougados, Maxime, Devauchelle‐Pensec, Valérie, Gaudin, Philippe, and Cormier, Grégoire

Subjects
RESEARCH funding, RHEUMATOID arthritis, STATISTICAL sampling, DRUG therapy, ABATACEPT, DISEASE remission, RANDOMIZED controlled trials, ANTIRHEUMATIC agents, DESCRIPTIVE statistics, INTRAVENOUS therapy, DOSE-effect relationship in pharmacology, DRUG efficacy, RESEARCH, TOCILIZUMAB, CONFIDENCE intervals, PATIENT aftercare
Abstract

Objective: We assess the clinical and structural impact at two years of progressively spacing tocilizumab (TCZ) or abatacept (ABA) injections versus maintenance at full dose in patients with rheumatoid arthritis in sustained remission. Methods: This multicenter open‐label noninferiority (NI) randomized clinical trial included patients with established rheumatoid arthritis in sustained remission receiving ABA or TCZ at a stable dose. Patients were randomized to treatment maintenance (M) at full dose (M‐arm) or progressive injection spacing (S) driven by the Disease Activity Score in 28 joints every 3 months up to biologics discontinuation (S‐arm). The primary end point was the evolution of disease activity according to the Disease Activity Score in 44 joints during the 2‐year follow‐up analyzed per protocol with a linear mixed‐effects model, evaluated by an NI test based on the one‐sided 95% confidence interval (95% CI) of the slope difference (NI margin 0.25). Other end points were flare incidence and structural damage progression. Results: Overall, 202 of the 233 patients included were considered for per protocol analysis (90 in S‐arm and 112 in M‐arm). At the end of follow‐up, 16.2% of the patients in the S‐arm could discontinue their biologic disease‐modifying antirheumatic drug, 46.9% tapered the dose and 36.9% returned to a full dose. NI was not demonstrated for the primary outcome, with a slope difference of 0.10 (95% CI 0.10–0.31) between the two arms. NI was not demonstrated for flare incidence (difference 42.6%, 95% CI 30.0–55.1) or rate of structural damage progression at two years (difference 13.9%, 95% CI −6.7 to 34.4). Conclusion: The Towards the Lowest Efficacious Dose trial failed to demonstrate NI for the proposed ABA or TCZ tapering strategy. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

25. An international multi-centre analysis of current prescribing practices and shared decision-making in psoriatic arthritis

Author

Watson, Lily, primary, Coyle, Conor, additional, Whately-Smith, Caroline, additional, Brooke, Melanie, additional, Kiltz, Uta, additional, Lubrano, Ennio, additional, Queiro, Rubén, additional, Trigos, David, additional, Brandt-Juergens, Jan, additional, Choy, Ernest, additional, D'Angelo, Salvatore, additional, Delle Sedie, Andrea, additional, Dernis, Emmanuelle, additional, Guis, Sandrine, additional, Helliwell, Philip, additional, Ho, Pauline, additional, Hueber, Axel J, additional, Joven, Beatriz, additional, Koehm, Michaela, additional, Montilla, Carlos, additional, Packham, Jon, additional, Pinto Tasende, José Antonio, additional, Ramirez Garcia, Felipe Julio, additional, Ruyssen-Witrand, Adeline, additional, Scrivo, Rossana, additional, Twigg, Sarah, additional, Soubrier, Martin, additional, Wirth, Théo, additional, Gossec, Laure, additional, and Coates, Laura C, additional

Published
2023
Full Text
View/download PDF

26. Ultrasonography and detection of subclinical joints and tendons involvements in Systemic Lupus erythematosus (SLE) patients: A cross-sectional multicenter study

Author

Salliot, Carine, Denis, Amélie, Dernis, Emmanuelle, Andre, Vincent, Perdriger, Aleth, Albert, Jean-David, Mammou Mraghni, Saloua, Griffoul-Espitalier, Isabelle, Hamidou, Mohamed, Le Goff, Benoit, Joulin, Sandrine Jousse, Marhadour, Thierry, Richez, Christophe, Poursac, Nicolas, Lazaro, Estebaliz, Rist, Stéphanie, Corondan, Anca, Quinten, Clara, Martaillé, Virginie, Valéry, Antoine, and Ducourau, Emilie

Published
2018
Full Text
View/download PDF

31. Psychometric validation of a patient-reported outcome questionnaire (Qualipsosex) assessing the impact of psoriasis and psoriatic arthritis on patient perception of sexuality

Author

Lespessailles, Eric, Mahé, Emmanuel, Reguiai, Ziad, Begon, Edouard, Maccari, François, Beneton, Nathalie, Chaby, Guillaume, Rosenberg, Carole, Dernis, Emmanuelle, Roux, Fabienne, Henry-Desailly, Isabelle, Charles, Bénédicte, Ferdynus, Cyril, Marty, Marc, and Esteve, Eric

Published
2021
Full Text
View/download PDF

32. Comparing COVID-19 disease severity in patients with rheumatic and inflammatory diseases between the first and the subsequent waves

Author

Drumez, Elodie, primary, Richez, Christophe, additional, Bebear, Louis, additional, Herasse, Muriel, additional, Flipo, René-Marc, additional, Marotte, Hubert, additional, Georgin-Lavialle, Sophie, additional, Seror, Raphaèle, additional, Pertuiset, Edouard, additional, Avouac, Jérôme, additional, Chazerain, Pascal, additional, Roux, Nicolas, additional, Pham, Thao, additional, Dernis, Emmanuelle, additional, Uzunhan, Yurdagul, additional, Servettaz, Amélie, additional, El Mahou, Soumaya, additional, Cacoub, Patrice, additional, Hamidou, Mohamed, additional, Fautrel, Bruno, additional, Thomas, Thierry, additional, and Hachulla, Eric, additional

Published
2023
Full Text
View/download PDF

33. Collecte et prise en charge de certaines comorbidités et facteurs de risque associés dans le cadre des rhumatismes inflammatoires chroniques dans la pratique quotidienne en France

Author

Gossec, Laure, Baillet, Athan, Dadoun, Sabrina, Daien, Claire, Berenbaum, Francis, Dernis, Emmanuelle, Fayet, Françoise, Hudry, Christophe, Mezieres, Maryse, Pouplin, Sophie, Richez, Christophe, Saraux, Alain, Savel, Carine, Senbel, Eric, Soubrier, Martin, Sparsa, Laëtitia, Wendling, Daniel, and Dougados, Maxime

Published
2017
Full Text
View/download PDF

34. Increased high molecular weight adiponectin and lean mass during tocilizumab treatment in patients with rheumatoid arthritis: a 12-month multicentre study

Author

Toussirot, Eric, Marotte, Hubert, Mulleman, Denis, Cormier, Grégoire, Coury, Fabienne, Gaudin, Philippe, Dernis, Emmanuelle, Bonnet, Christine, Damade, Richard, Grauer, Jean-Luc, Abdesselam, Tassadit Ait, Guillibert-Karras, Caroline, Lioté, Frédéric, Hilliquin, Pascal, Sacchi, Antoinette, Wendling, Daniel, Le Goff, Benoît, Puyraveau, Marc, and Dumoulin, Gilles

Published
2020
Full Text
View/download PDF

35. Pregnancy outcomes in women with primary Sjögren's syndrome: an analysis of data from the multicentre, prospective, GR2 study

Author

de Frémont, Grégoire Martin, primary, Costedoat-Chalumeau, Nathalie, additional, Lazaro, Estibaliz, additional, Belkhir, Rakiba, additional, Guettrot-Imbert, Gaëlle, additional, Morel, Nathalie, additional, Nocturne, Gaétane, additional, Molto, Anna, additional, Goulenok, Tiphaine, additional, Diot, Elisabeth, additional, Perard, Laurent, additional, Ferreira-Maldent, Nicole, additional, Le Besnerais, Maelle, additional, Limal, Nicolas, additional, Martis, Nihal, additional, Abisror, Noémie, additional, Debouverie, Odile, additional, Richez, Christophe, additional, Sobanski, Vincent, additional, Maurier, François, additional, Sauvetre, Gaëtan, additional, Levesque, Hervé, additional, Timsit, Marie-Agnès, additional, Tieulié, Nathalie, additional, Orquevaux, Pauline, additional, Bienvenu, Boris, additional, Mahevas, Matthieu, additional, Papo, Thomas, additional, Lartigau-Roussin, Céline, additional, Chauvet, Elodie, additional, Berthoux, Emilie, additional, Sarrot-Reynauld, Françoise, additional, Raffray, Loïc, additional, Couderc, Marion, additional, Silva, Nicolas Martin, additional, Jourde-Chiche, Noémie, additional, Belhomme, Nicolas, additional, Thomas, Thierry, additional, Poindron, Vincent, additional, Queyrel-Moranne, Viviane, additional, Delforge, Juliette, additional, Le Ray, Camille, additional, Pannier, Emmanuelle, additional, Mariette, Xavier, additional, Le Guern, Véronique, additional, Seror, Raphaèle, additional, AUDEMARD-VERGER, Alexandra, additional, AZZI, Emmanuel, additional, BANNEVILLE, Béatrice, additional, BAUDET, Antoine, additional, BEAUDOUIN BAZIRE, Constance, additional, BELIZNA, Cristina, additional, Belot, Alexandre, additional, BENHAMOU, Ygal, additional, Berezné, Alice, additional, BERNARD-GUERVILLY, Fanny, additional, BERTHIER, Sabine, additional, BEZANAHARY, Holy, additional, BIALE, Lisa, additional, BIGOT, Adrien, additional, BLANCHARD-DELAUNAY, Claire, additional, CALAS, Anne, additional, CAMPAGNE, Julien, additional, CATHEBRAS, Pascal, additional, CAZALETS, Claire, additional, CHAIGNE, Benjamin, additional, CHANDESRIS, Olivia, additional, CHATELAIS, Jérémy, additional, CHATELUS, Emmanuel, additional, COHEN, Fleur, additional, Combe, Bernard, additional, COMPARON, Céline, additional, COQUERELLE, Pascal, additional, DAMIAN, Louise, additional, DAUGAS, Eric, additional, DE MENTHON, Mathilde, additional, DE MOREUIL, Claire, additional, DELATTRE, Estelle, additional, DELLAL, Azeddine, additional, Deneux-Tharaux, Catherine, additional, DENIS, Amélie, additional, DEPROUW, Camille, additional, DERNIS, Emmanuelle, additional, DEROUX, Alban, additional, DESOUCHES, Sandra, additional, Dieudé, Philippe, additional, DIREZ, Guillaume, additional, Dougados, Maxime, additional, DRIESSEN, Marine, additional, DU THANH, Aurélie, additional, DUNOGEANT, Laetitia, additional, DURANT, Cécile, additional, DUREL, Cécile-Audrey, additional, DURIEU, Isabelle, additional, EBOUE, Florence, additional, Elefant, Elisabeth, additional, FAIN, Olivier, additional, FAUTREL, Bruno, additional, FLIPO, René-Marc, additional, FRAZIER, Aline, additional, FROISSART, Antoine, additional, GEORGIN-LAVIALLE, Sophie, additional, GERVAIS, Elisabeth, additional, GODEAU, Bertrand, additional, Goffinet, François, additional, GOMPEL, Anne, additional, GOSSEC, Laure, additional, GOUPILLE, Philippe, additional, GRANGE, Claire, additional, GUILLAUD-DANIS, Constance, additional, HACHULLA, Eric, additional, HOEFSLOOT, Sabine, additional, HUMMEL, Aurélie, additional, JEGO, Patrick, additional, JOBARD, Stéphanie, additional, JOSSELIN-MAHR, Laurence, additional, LAMBERT, Marc, additional, LANGLOIS, Vincent, additional, LARIVIERE, Delphine, additional, LARROCHE, Claire, additional, LATOURTE, Augustin, additional, LAVIGNE, Christian, additional, LE GALLOU, Thomas, additional, LEROUX, Gaëlle, additional, LETAROUILLY, Jean Guillaume, additional, LIOTÉ, Frédéric, additional, Loeuillet, Laurence, additional, London, Jonathan, additional, Loustau, Valentine, additional, LOZAC'H, Pierre, additional, MAHEU, Emmanuel, additional, MAILLARD, Hélène, additional, MAROTTE, Hubert, additional, MASSEAU, Agathe, additional, MEKINIAN, Arsène, additional, Melboucy Belkhir, Sara, additional, Miceli-Richard, Corinne, additional, MICHAUD, Martin, additional, MICHEL, Marc, additional, MORANNE, Olivier, additional, MORATI-HAFSAOUI, Chafika, additional, MOULIS, Guillaume, additional, MOUTHON, Luc, additional, NICOLAS, Barbara, additional, Nizard, Jacky, additional, ORA, Jérémy, additional, OUTH, Rodérau, additional, PASQUIER, Elisabeth, additional, PENNAFORTE, Jean-Loup, additional, PERLAT, Antoinette, additional, PETIT-BAUER, Hélène, additional, PILLEBOUT, Evangeline, additional, PIOT, Jean-Maxime, additional, PORTIER, Agnès, additional, Pourrat, Olivier, additional, PUECHAL, Xavier, additional, PUGNET, Gregory, additional, REDONDIN, Manon, additional, REGENT, Alexis, additional, RORIZ, Mélanie, additional, SAILLER, Laurent, additional, SAVEY, Léa, additional, SCHERLINGER, Marc, additional, SCHLEINITZ, Nicolas, additional, Sellam, Jérémie, additional, Sentilhes, Loïc, additional, SERVAIS, Aude, additional, SMETS, Perrine, additional, SORDET, Christelle, additional, SOUBRIER, Martin, additional, STANKOVIC-STOJANOVIC, Katia, additional, URBANSKI, Geoffrey, additional, VEIT, Véronique, additional, WEBER, Emmanuelle, additional, and YELNIK, Cécile, additional

Published
2023
Full Text
View/download PDF

36. P174 Psoriatic arthritis patients in the UK have a lower quality of life than patients in mainland Europe - an analysis from the ASSIST study

Author

Coyle, Conor, primary, Watson, Lily, additional, Brooke, Melanie, additional, Kiltz, Uta, additional, Lubrano, Ennio, additional, Queiro, Ruben, additional, Trigos, David, additional, Brandt-Jürgens, Jan, additional, D'Angelo, Salvatore, additional, Sedie, Andrea Delle, additional, Dernis, Emmanuelle, additional, Helliwell, Philip, additional, Ho, Pauline, additional, Hueber, Axel, additional, Ibáñez, Beatriz Joven, additional, Köhm, Michaela, additional, Morales, Carlos Montilla, additional, Packham, Jon, additional, Tasende, José Antonio Pinto, additional, García, Felipe Julio Ramíez, additional, Ruyssen-witrand, Adeline, additional, Scrivo, Rossana, additional, Twigg, Sarah, additional, Welcker, Martin, additional, Soubrier, Martin, additional, Wirth, Theo, additional, Gossec, Laure, additional, and Coates, Laura, additional

Published
2023
Full Text
View/download PDF

37. P178 Current prescribing practices in psoriatic arthritis - comparison between the UK and Europe

Author

Watson, Lily, primary, Coyle, Conor, additional, Brooke, Melanie, additional, Kiltz, Uta, additional, Lubrano, Ennio, additional, Queiro, Rubén, additional, Trigos, David, additional, Brandt-Juergens, Jan, additional, D'Angelo, Salvatore, additional, Sedie, Andrea Delle, additional, Dernis, Emmanuelle, additional, Helliwell, Philip, additional, Ho, Pauline, additional, Hueber, Axel, additional, Joven, Beatriz, additional, Koehm, Michaela, additional, Montilla, Carlos, additional, Packham, Jon, additional, Tasende, José P, additional, Garcia, Felipe J R, additional, Ruyssen-Witrand, Adeline, additional, Scrivo, Rossana, additional, Twigg, Sarah, additional, Welcker, Martin, additional, Soubrier, Martin, additional, Wirth, Theo, additional, Gossec, Laure, additional, and Coates, Laura C, additional

Published
2023
Full Text
View/download PDF

38. P179 Shared decision-making in psoriatic arthritis consultations

Author

Watson, Lily L, primary, Coyle, Conor, additional, Brooke, Melanie, additional, Kiltz, Uta, additional, Lubrano, Ennio, additional, Queiro, Rubén, additional, Trigos, David, additional, Brandt-Juergens, Jan, additional, D'Angelo, Salvatore, additional, Sedie, Andrea Delle, additional, Dernis, Emmanuelle, additional, Helliwell, Philip, additional, Ho, Pauline, additional, Hueber, Axel, additional, Joven, Beatriz, additional, Koehm, Michaela, additional, Montilla, Carlos, additional, Packham, Jon, additional, Tasende, José P, additional, Garcia, Felipe J R, additional, Ruyssen-Witrand, Adeline, additional, Scrivo, Rossana, additional, Twigg, Sarah, additional, Welcker, Martin, additional, Soubrier, Martin, additional, Wirth, Theo, additional, Gossec, Laure, additional, and Coates, Laura C, additional

Published
2023
Full Text
View/download PDF

39. Collection and management of selected comorbidities and their risk factors in chronic inflammatory rheumatic diseases in daily practice in France

Author

Gossec, Laure, Baillet, Athan, Dadoun, Sabrina, Daien, Claire, Berenbaum, Francis, Dernis, Emmanuelle, Fayet, Françoise, Hudry, Christophe, Mezieres, Maryse, Pouplin, Sophie, Richez, Christophe, Saraux, Alain, Savel, Carine, Senbel, Eric, Soubrier, Martin, Sparsa, Laëtitia, Wendling, Daniel, and Dougados, Maxime

Published
2016
Full Text
View/download PDF

40. NSAID Exposure Delays Time-to-Conception in Patients with Spondyloarthritis: An Analysis of the GR2 Prospective Cohort

Author

Hamroun, Sabrina, primary, Couderc, Marion, additional, Flipo, René-Marc, additional, Sellam, Jérémie, additional, Richez, Christophe, additional, Dernis, Emmanuelle, additional, Frazier, Aline, additional, Gossec, Laure, additional, Gervais, Elisabeth, additional, Marotte, Hubert, additional, Dunogeant, Laetitia, additional, Lukas, Cédric, additional, Deroux, Alban, additional, Guettrot-Imbert, Gaelle, additional, Le Guern, Véronique, additional, Costedoat-Chalumeau, Nathalie, additional, Molto, Anna, additional, and Group, anon, additional

Published
2023
Full Text
View/download PDF

41. Erratum to “2022 French Society for Rheumatology (SFR) recommendations on the everyday management of patients with spondyloarthritis, including psoriatic arthritis” [Joint Bone Spine 2022;89:105344]

Author

Wendling, Daniel, primary, Hecquet, Sophie, additional, Fogel, Olivier, additional, Letarouilly, Jean-Guillaume, additional, Verhoeven, Frank, additional, Pham, Thao, additional, Prati, Clément, additional, Molto, Anna, additional, Goupille, Philippe, additional, Dernis, Emmanuelle, additional, Saraux, Alain, additional, Ruyssen-Witrand, Adeline, additional, Lukas, Cédric, additional, Miceli-Richard, Corinne, additional, Hudry, Christophe, additional, Richette, Pascal, additional, Breban, Maxime, additional, Gossec, Laure, additional, Dougados, Maxime, additional, and Claudepierre, Pascal, additional

Published
2022
Full Text
View/download PDF

42. The learning curve of nurses for the assessment of swollen and tender joints in rheumatoid arthritis

Author

Cheung, Peter P., Dougados, Maxime, Andre, Vincent, Balandraud, Nathalie, Chalès, Gérard, Chary-Valckenaere, Isabelle, Dernis, Emmanuelle, Gill, Ghislaine, Gilson, Melanie, Guis, Sandrine, Mouterde, Gael, Pavy, Stephan, Pouyol, Francois, Marhadour, Thierry, Richette, Pascal, Ruyssen-Witrand, Adeline, Soubrier, Martin, Nguyen, Minh, and Gossec, Laure

Published
2014
Full Text
View/download PDF

45. Effect of Tocilizumab on Disease Activity in Patients With Active Polymyalgia Rheumatica Receiving Glucocorticoid Therapy

Author

Devauchelle-Pensec, Valérie, Carvajal-Alegria, Guillermo, Dernis, Emmanuelle, Richez, Christophe, Truchetet, Marie-Elise, Wendling, Daniel, Toussirot, Eric, Perdriger, Aleth, Gottenberg, Jacques-Eric, Felten, Renaud, Fautrel, Bruno Jean, Chiche, Laurent, Hilliquin, Pascal, Le Henaff, Catherine, Dervieux, Benjamin, Direz, Guillaume, Chary-Valckenaere, Isabelle, Cornec, Divi, Guellec, Dewi, Marhadour, Thierry, Nowak, Emmanuel, Saraux, Alain, Inserm UMR 1227 Immunothérapies et Pathologies Lymphocytaires B, Hôpital Morvan - CHRU de Brest (CHU - BREST ), Centre d'Investigation Clinique de Besançon (Inserm CIC 1431), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté])-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), CHU Pontchaillou [Rennes], Université de Rennes (UR), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), CIC Brest, Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital de la Cavale Blanche, and The funders of this study were the French National Program for Clinical Research and the study sponsor (ie, the Brest University Hospital). Roche-Chugai Pharmaceutical provided an unconditional grant for the study and donated the tocilizumab used for the study.

Subjects
MESH: Aged, MESH: Humans, MESH: Administration, Intravenous, [SDV]Life Sciences [q-bio], MESH: Giant Cell Arteritis, MESH: Interleukin-6, MESH: Male, MESH: Drug Tapering, MESH: Polymyalgia Rheumatica, MESH: Antibodies, Monoclonal, Humanized, MESH: Anti-Inflammatory Agents, MESH: Administration, Oral, MESH: C-Reactive Protein, MESH: Double-Blind Method, MESH: Glucocorticoids, MESH: Prednisone, MESH: Female
Abstract

International audience; Importance: Few treatments are available for patients with glucocorticoid-dependent polymyalgia rheumatica. IL-6 antagonists may reduce disease activity in patients with active glucocorticoid-dependent polymyalgia rheumatica.Objective: To compare the efficacy of tocilizumab vs placebo in patients with glucocorticoid-dependent polymyalgia rheumatica.Design, setting, and participants: This double-blind, parallel-group, placebo-controlled randomized clinical trial enrolled 101 patients with polymyalgia rheumatica at 17 hospitals in France from February 2017 to October 2019. Final follow-up occurred in November 2020. Inclusion criteria were persistent disease activity (polymyalgia rheumatica activity score computed using the C-reactive protein level [CRP PMR-AS] >10) and prednisone dose greater than or equal to 10 mg per day.Interventions: Patients were randomly assigned to receive intravenous tocilizumab (8 mg/kg; n = 51) or placebo (n = 50) every 4 weeks for 24 weeks, combined with predefined standardized tapering of oral prednisone.Main outcomes and measures: The primary efficacy end point was CRP PMR-AS less than 10 (range, 0-100; higher values indicate greater activity; no minimal clinically important difference defined) combined with either prednisone dose less than or equal to 5 mg per day or a decrease in prednisone dose greater than or equal to 10 mg from baseline at week 24. There were 11 secondary outcomes assessed at week 24 included in this report, including disease activity (measured by CRP PMR-AS) and the proportion of patients no longer taking prednisone.Results: Of the 101 randomized patients (mean age, 67.2 years; 68 [67.3%] women), 100 (99%) received at least 1 infusion and 100 completed the trial. The primary end point was achieved in 67.3% of patients in the tocilizumab group and 31.4% of patients in the placebo group (adjusted difference, 36.0% [95% CI, 19.4%-52.6%]; adjusted relative risk, 2.3 [95% CI, 1.5-3.6]; P < .001). Of 11 reported secondary end points at 24 weeks, 7 showed significant differences favoring tocilizumab, including mean CRP PMR-AS score (7.5 [95% CI, 5.4-9.6] vs 14.9 [95% CI, 11.4-18.4]; adjusted difference, -7.5 [95% CI, -11.2 to -3.8]; P < .001) and the percentage of patients no longer receiving prednisone (49.0% vs 19.6%; adjusted difference, 29.3% [95% CI, 18.9%-39.7%]; adjusted relative risk, 2.5 [95% CI, 1.8-3.5]; P < .001). The most frequent adverse events were infections, experienced by 23 patients (46.9%) in the tocilizumab group and 20 (39.2%) in the placebo group.Conclusions and relevance: Among patients with active polymyalgia rheumatica despite prednisone therapy, tocilizumab, compared with placebo, resulted in a significantly greater percentage of patients with a CRP PMR-AS less than 10 with reduced prednisone requirements at week 24. Further research is needed to confirm efficacy and to determine the balance of potential benefits and harms.

Published
2022
Full Text
View/download PDF

46. Effect of Tocilizumab on Disease Activity in Patients With Active Polymyalgia Rheumatica Receiving Glucocorticoid Therapy

Author

Devauchelle-Pensec, Valérie, primary, Carvajal-Alegria, Guillermo, additional, Dernis, Emmanuelle, additional, Richez, Christophe, additional, Truchetet, Marie-Elise, additional, Wendling, Daniel, additional, Toussirot, Eric, additional, Perdriger, Aleth, additional, Gottenberg, Jacques-Eric, additional, Felten, Renaud, additional, Fautrel, Bruno Jean, additional, Chiche, Laurent, additional, Hilliquin, Pascal, additional, Le Henaff, Catherine, additional, Dervieux, Benjamin, additional, Direz, Guillaume, additional, Chary-Valckenaere, Isabelle, additional, Cornec, Divi, additional, Guellec, Dewi, additional, Marhadour, Thierry, additional, Nowak, Emmanuel, additional, and Saraux, Alain, additional

Published
2022
Full Text
View/download PDF

47. Development and Validation of a Self-Administered Questionnaire Measuring Essential Knowledge in Patients With Axial Spondyloarthritis

Author

Beauvais, Catherine, primary, Pereira, Bruno, additional, Pham, Thao, additional, Sordet, Christelle, additional, Claudepierre, Pascal, additional, Fayet, Françoise, additional, Wendling, Daniel, additional, Costantino, Félicie, additional, Carton, Laurence, additional, Grange, Laurent, additional, Soubrier, Martin, additional, Legoupil, Nathalie, additional, Perdriger, Aleth, additional, Tavares, Isabel, additional, Dernis, Emmanuelle, additional, Gossec, Laure, additional, and Rodère, Malory, additional

Published
2022
Full Text
View/download PDF

48. Améliorer le consensus autour de l’évaluation de la synovite dans la polyarthrite rhumatoïde

Author

Cheung, Peter P., Dougados, Maxime, Andre, Vincent, Balandraud, Nathalie, Chales, Gérard, Chary-Valckenaere, Isabelle, Chatelus, Emmanuel, Dernis, Emmanuelle, Gill, Ghislaine, Gilson, Mélanie, Guis, Sandrine, Mouterde, Gael, Pavy, Stéphane, Pouyol, François, Marhadour, Thierry, Richette, Pascal, Ruyssen-Witrand, Adeline, Soubrier, Martin, and Gossec, Laure

Published
2013
Full Text
View/download PDF

49. Improving agreement in assessment of synovitis in rheumatoid arthritis

Author

Cheung, Peter P., Dougados, Maxime, Andre, Vincent, Balandraud, Nathalie, Chales, Gérard, Chary-Valckenaere, Isabelle, Chatelus, Emmanuel, Dernis, Emmanuelle, Gill, Ghislaine, Gilson, Mélanie, Guis, Sandrine, Mouterde, Gael, Pavy, Stephan, Pouyol, François, Marhadour, Thierry, Richette, Pascal, Ruyssen-Witrand, Adeline, Soubrier, Martin, and Gossec, Laure

Published
2013
Full Text
View/download PDF

50. Variability of Primary Sjögren's Syndrome Is Driven by Interferon α and Interferon α Blood Levels Are Associated With the Class II HLA–DQ Locus

Author

Trutschel, Diana, Bost, Pierre, Mariette, Xavier, Bondet, Vincent, Llibre, Alba, Posseme, Celine, Charbit, Bruno, Thorball, Christian W., Jonsson, Roland, Lessard, Christopher J., Felten, Renaud, Ng, Wan Fai, Chatenoud, Lucienne, Dumortier, Hélène, Sibilia, Jean, Fellay, Jacques, Brokstad, Karl A., Appel, Silke, Tarn, Jessica R., Quintana‐Murci, Lluis, Mingueneau, Michael, Meyer, Nicolas, Duffy, Darragh, Schwikowski, Benno, Gottenberg, Jacques Eric, Dernis, Emmanuelle, Devauchelle‐Pensec, Valerie, Dieude, Philippe, Dubost, Jean‐Jacques, Fauchais, Anne‐Laure, Goeb, Vincent, Hachulla, Eric, Hatron, Pierre Yves, Larroche, Claire, Le Guern, Véronique, Morel, Jacques, Perdriger, Aleth, Salliot, Carinne, Rist, Stephanie, Saraux, Alain, Vittecoq, Olivier, Nocturne, Gaétane, Ravaud, Philippe, Seror, Raphaèle, Abel, Laurent, Alcover, Andres, Aschard, Hugues, Astrom, Kalla, Bousso, Philippe, Bruhns, Pierre, Cumano, Ana, Demangel, Caroline, Deriano, Ludovic, Di Santo, James, Dromer, Françoise, Eberl, Gérard, Enninga, Jost, Gelpi, Odile, GompertsBoneca, Ivo, Hasan, Milena, Hercberg, Serge, Lantz, Olivier, Leclerc, Claude, Mouquet, Hugo, Pellegrini, Sandra, Pol, Stanislas, Rausell, Antonio, Rogge, Lars, Sakuntabhai, Anavaj, Schwartz, Olivier, Shorte, Spencer, Soumelis, Vassili, Tangy, Frédéric, Tartour, Eric, Toubert, Antoine, Touvier, Mathilde, Ungeheuer, Marie‐Noëlle, Albert, Matthew L., Biomédecine computationelle des systèmes / Computational systems biomedicine, Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), Universität Zürich [Zürich] = University of Zurich (UZH), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Service de Rhumatologie [CHU Bicêtre], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, Immunologie des maladies virales, auto-immunes, hématologiques et bactériennes (IMVA-HB), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Projet NECESSITY (PN), Hôpitaux Universitaires Paris Sud [AP-HP] (HUPS)-Immunologie des maladies virales, auto-immunes, hématologiques et bactériennes (IMVA-HB), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Immunologie Translationnelle - Translational Immunology lab, Cytometrie et Biomarqueurs – Cytometry and Biomarkers (UTechS CB), Ecole Polytechnique Fédérale de Lausanne (EPFL), Université de Lausanne = University of Lausanne (UNIL), Lausanne University Hospital, University of Bergen (UiB), Oklahoma Medical Research Foundation (OMRF), University of Oklahoma Health Sciences Center (OUHSC), Université de Strasbourg (UNISTRA), Institut de biologie moléculaire et cellulaire (IBMC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Newcastle University [Newcastle], Newcastle Upon Tyne Hospitals NHS Foundation Trust, Institut Necker Enfants-Malades (INEM - UM 111 (UMR 8253 / U1151)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Immunologie, Immunopathologie et Chimie Thérapeutique (I2CT), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Génétique Evolutive Humaine - Human Evolutionary Genetics, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Biogen Inc. [Cambridge, MA, USA], Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Supported by the Innovative Medicines Initiative 2 Joint Undertaking (JU) (grant 806975). The JU receives support from the European Union’s Horizon 2020 research and innovation program and the European Unionand the European Federation of Pharmaceutical Industries and Associations. This work was also supported by the National Institutes of Health (National Institute of Arthritis and Musculoskeletal Skin Disease grant R01-AR-065953). The Assessment of Systemic Signs and Evolution in Sjögren’s Syndrome(ASSESS) national multicenter prospective cohort was formed in 2006 with aFrench Ministry of Health grant (Programme Hospitalier de Recherche Clinique 2005 P060228). The ASSESS cohort is promoted by the French Society of Rheumatology and receives research grants from the French Society of Rheumatology. Dr. Gottenberg’s work was supported by Bristol Myers Squibbfor transcriptomic analysis of the ASSESS and Norwegian cohorts and by Geneviève Garnier (Association Française du Syndrome de Gougerot-Sjögrenet des syndromes secs). Drs. Trutschel’s and Schwikowski’s work was supported by Geneviève Garnier (Association Française du Syndrome de Gougerot-Sjögren et des syndromes secs)., Milieu Intérieur Consortium, ASSESS study investigators, and NECESSITY Consortium: Emmanuelle Dernis, Valerie Devauchelle-Pensec, Philippe Dieude, Jean-Jacques Dubost, Anne-Laure Fauchais, Vincent Goeb, Eric Hachulla, Pierre Yves Hatron, Claire Larroche, Véronique Le Guern, Jacques Morel, Aleth Perdriger, Carinne Salliot, Stephanie Rist, Alain Saraux, Jean Sibilia, Olivier Vittecoq, Gaétane Nocturne, Philippe Ravaud, Raphaèle Seror, Laurent Abel, Andres Alcover, Hugues Aschard, Kalla Astrom, Philippe Bousso, Pierre Bruhns, Ana Cumano, Caroline Demangel, Ludovic Deriano, James Di Santo, Françoise Dromer, Gérard Eberl, Jost Enninga, Jacques Fellay, Odile Gelpi, Ivo GompertsBoneca, Milena Hasan, Serge Hercberg, Olivier Lantz, Claude Leclerc, Hugo Mouquet, Sandra Pellegrini, Stanislas Pol, Antonio Rausell, Lars Rogge, Anavaj Sakuntabhai, Olivier Schwartz, Benno Schwikowski, Spencer Shorte, Vassili Soumelis, Frédéric Tangy, Eric Tartour, Antoine Toubert, Mathilde Touvier, Marie-Noëlle Ungeheuer, Matthew L Albert, Darragh Duffy, Lluis Quintana-Murci., European Project: 806975,NECESSITY, Clauss, Isabelle, and NEw Clinical Endpoints in primary Sjögren’s Syndrome: an Interventional Trial based on stratifYing patients - NECESSITY - 0000-00-00 - 0000-00-00 - 806975 - VALID

Subjects
Proteomics, [SDV.MHEP.RSOA] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Sjogren's Syndrome, Rheumatology, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, HLA-DQ Antigens, Immunology, Humans, Interferon-alpha, Immunology and Allergy, Prospective Studies
Abstract

Objective: Primary Sjögren's syndrome (SS) is the second most frequent systemic autoimmune disease, affecting 0.1% of the general population. To characterize the molecular and clinical variabilities among patients with primary SS, we integrated transcriptomic, proteomic, cellular, and genetic data with clinical phenotypes in a cohort of 351 patients with primary SS. Methods: We analyzed blood transcriptomes and genotypes of 351 patients with primary SS who were participants in a multicenter prospective clinical cohort. We replicated the transcriptome analysis in 3 independent cohorts (n = 462 patients). We determined circulating interferon-α (IFNα) and IFNγ protein concentrations using digital single molecular arrays (Simoa). Results: Transcriptome analysis of the prospective cohort showed a strong IFN gene signature in more than half of the patients; this finding was replicated in the 3 independent cohorts. Because gene expression analysis did not discriminate between type I IFN and type II IFN, we used Simoa to demonstrate that the IFN transcriptomic signature was driven by circulating IFNα and not by IFNγ protein levels. IFNα protein levels, detectable in 75% of patients, were significantly associated with clinical and immunologic features of primary SS disease activity at enrollment and with increased frequency of systemic complications over the 5-year follow-up. Genetic analysis revealed a significant association between IFNα protein levels, a major histocompatibility (MHC) class II haplotype, and anti-SSA antibody. Additional cellular analysis revealed that an MHC class II HLA–DQ locus acts through up-regulation of HLA class II molecules on conventional dendritic cells. Conclusion: We identified the predominance of IFNα as a driver of primary SS variability, with IFNα demonstrating an association with HLA gene polymorphisms., Arthritis & Rheumatology, 74 (12), ISSN:2326-5191, ISSN:2326-5205

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results