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Copyright of Revista Foco (Interdisciplinary Studies Journal) is the property of Revista Foco and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Foco (Interdisciplinary Studies Journal) is the property of Revista Foco and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The use of optical imaging technology in recent years has improved diagnostics in the dermatology area. The techniques that can be named are optical coherence tomography, Raman spectroscopy, and optoacoustic imaging. Each technique has applications in general medicine and dermatology but with their respective limitations and focus. This work reviews the imaging techniques in general, prioritizing the theoretical background that allows the technique to operate, and then an image example obtained with the technique is shown. Then, an extensive review of the techniques of hyperspectral imaging and hyperspectral polarized dermatoscope is made. Finally, we talk about new trends in optical imaging future. [ABSTRACT FROM AUTHOR]

BACKGROUND: Trichotillomania is defined by the DSM-5 as a disorder in which the patient pulls out their hair on a consistent basis, whether it be hair from the scalp, eyebrows, or any other region of their body. It causes significant functional impairment. This disorder is considered among the compulsive obsessive disorders. The areas most frequently affected are scalp, eyebrows, eye lashes and pubic hair. Lifetime prevalence is estimated between 0.6-1%. CLINICAL CASE: A 51-year-old female patient, who had presented symptoms of anxiety for the past 11 years. In the past 4 years symptoms had worsen progressively with compulsive night hair pulling which intensified after social stressors. At external inspection at the frontoparietal area of the scalp we found a localized alopecia with an irregular circumference of approximately 10 cm in diameter, so secondary neuromechanical alopecia was diagnosed. CONCLUSIONS: In several psychopathologies, hair pulling can be a symptom, so a psychiatric consult is very important to evaluate comorbidities and classify the symptom of hair pulling within the clinical picture. Like other dermatoses of psychic origin, the diagnosis of trichotillomania does not imply that these patients should be treated only by the psychiatrist. The Dermatology service plays an important role in hair pulling disorder. [ABSTRACT FROM AUTHOR]

A criptococose é uma doença fúngica causada por diferentes variedades do complexo Cryptococcus neoformans. Trata-se de um microrganismo oportunista que acomete, majoritariamente, indivíduos imunocomprometidos. A patologia é multissistêmica e, por isso, os sinais clínicos são variados sendo, o trato tegumentar, pouco relatado. Há diferentes métodos de diagnósticos definitivos variando de citologia das lesões e de biópsias, a testes sorológicos, moleculares e culturas fúngicas, sendo este considerado o padrão ouro. Quanto ao tratamento, consiste em um processo longo variando de semanas a meses com drogas que apresentam efeitos colaterais importantes, sendo os antifúngicos sistêmicos os preconizados. Objetivou-se relatar um caso dessa patologia em um cão atendido por uma clínica veterinária particular, bem como os seus principais aspectos clínicos. O animal apresentava lesões ulcerativas nos membros torácico e pélvico esquerdos com evolução de uma semana. O diagnóstico foi confirmado pela citologia direta e a terapêutica baseou-se no uso de itraconazol por via oral na dose de 10 mg/kg a cada 24 horas por 90 dias, hepvet, meio comprimido a cada 24 horas durante todo o tratamento, eritrós tabs, um tablete a cada 24 horas por 30 dias, e terapia tópica com shampoo Micodine a cada 3 dias.

This study aimed to report a case of atopic dermatitis in a dog with exclusive manifestation in the periocular region and its therapeutic management. A male dog, crossbreed, 3 years old, was evaluated with a history of pruritic dermatological problem with a time of evolution of two years. The animal presented ulceration, hyperpigmentation, lichenification, purulent discharge, and fissures in the periocular region, in 360°, bilaterally. Ectoparasites and food allergies had already been excluded. A skin biopsy followed by histopathological analysis was performed. The microscopic evaluation suggested allergic dermatopathy. Thus, the findings of physical and histopathologic exams conducted to the diagnosis of canine atopic dermatitis (CAD). Oclacitinib therapy was instituted with an initial dose of 0.4 mg/kg every 12 hours for 14 days followed by a maintenance dose of 0.4 mg/kg every 24 hours. In addition, a topical product based on fatty acids and ceramides was used weekly, continuously. After 30 days, regression of skin lesions and ocular signs was noted, as well as complete remission of pruritus and absence of side effects. After 240 days of treatment, the pruritus relapsed, requiring a change in the frequency of administration to 0.4 mg/kg, every 12 hours, with remission of clinical signs occurring. Therefore, it can be concluded that cases of chronic lesions and intense pruritus in the periocular region should be evaluated and is important to consider the possibility of atopic dermatitis. The use of drugs, such as oclacitinib, for the control of CAD has shown satisfactory results. [ABSTRACT FROM AUTHOR]

Copyright of Polish Journal of Allergology / Alergologia Polska is the property of Termedia Publishing House and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

OBJECTIVE: To determine if values of serum ferritin level ≤ 70 ng/mL represents a factor associated to the risk for diffuse alopecia in female patients among 12 and 50 years old. MATERIALS AND METHODS: An observational, retrospective, analytical, case-control study was carried out in patients treated at the dermatology service of the Hospital Belen de Trujillo, Peru, from January 2015 to December 2021. Clinical and demographic data were collected, as well as levels of serum ferritin. Patients with other comorbidities that could be etiological factors of alopecia were excluded. RESULTS: Seventeen-eight female patients were included. They were grouped into 39 cases with a diagnosis of diffuse alopecia, while another 39 controls without diffuse alopecia. Low serum ferritin levels were found in 28% of the patients in the diffuse alopecia group, while in the control, 90% had serum ferritin levels within normal values. Patients with serum ferritin levels ≤ 70 ng/mL had a 3.43-fold increased risk of developing diffuse alopecia compared with patients with ferritin levels > 70 ng/mL (OR 3.4375; 95%CI: 0.98-11.97, p < 0.05). CONCLUSIONS: Low serum ferritin levels (≤ 70 ng/mL) in female patients are a risk factor of diffuse alopecia. [ABSTRACT FROM AUTHOR]

Copyright of Nefrologia is the property of Revista Nefrologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Health & Society is the property of Instituto de Ensino e Pesquisa Periodicojs and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Belleza y salud, una cualidad y un estado que siempre han ido de la mano. La mayoría de las mujeres embarazadas desarrollan cambios en la piel, incluidos cambios fisiológicos u hormonales, empeoramiento de afecciones cutáneas preexistentes o aparición de nuevas dermatosis durante el embarazo. Bajo la influencia de las hormonas del embarazo, el tejido cutáneo sufre varias modificaciones, estas manifestaciones en la piel pueden incluir: prurito, cloasma, estrías, rosácea y telangiectasias vasculares, que son motivo de preocupación, y las coloca en una situación de incertidumbre para escoger, en la diversidad de opciones de tratamientos, el que tenga buen perfil de seguridad, para mantener su apariencia y salud. En el artículo de revisión narrativa se busca especificar las principales alteraciones dermatológicas en las embarazadas, así como el diagnóstico y tratamiento de cada una de ellas desde la perspectiva de la cosmiatría. Metodología: búsqueda de la literatura científica en bases de datos médicas Pubmed, Elsevier, Cochrane, Revencyt, también en buscadores como Google y Google Académico y bibliotecas virtuales utilizando palabras clave. De acuerdo a los datos recopilados se identificaron y clasificaron las alteraciones dermatológicas más importantes en mujeres embarazadas, analizar los tratamientos empleados en cosmiatría para cada alteración dermatológica, incluyendo sus beneficios, riesgos y consideraciones especiales durante el embarazo. Aunque la mayoría de los tratamientos, inexactamente se recomiendan para ser utilizados después del parto, existen algunas alternativas para prevenir y tratar las lesiones cutáneas durante el embarazo, por lo que es necesaria información actualizada y completa sobre la cosmiatría durante el embarazo.

The skin is an important organ. Its function is influenced by the environment, as it is involved with the identity of the subject, self-esteem, and functions as the letter of identification of the person. The unbalance between mind and skin may cause certain diseases. Psycodermatology is a branch of Dermatology which works with the association between certain dermatological diseases and associated psychiatric illnesses. Many times, psychiatric diseases may trigger skin diseases, which means that a proper identification, diagnosis and treatment of these illnesses is a key piece, while a proper referral to mental health services is essential for an integral approach and treatment. We made a review of literature by means of the PubMed database from the years 2010 to 2021about psychodermatology, including the most relevant articles for our review. The keywords used for the search were dermatology, psychiatry, psychodermatology, somatic diseases, psychiatric skin diseases. We included articles in English or Spanish. We found 84 related articles but included only 30 relevant to our search and excluded 54 of them for lack of relevance. It is important to mention the finding of a lack of interdisciplinary work between Dermatology and Psychiatry for the proper diagnosis and approach of this group of diseases; emotional triggers may exacerbate the patient's skin illnesses. [ABSTRACT FROM AUTHOR]

BACKGROUND: Histoplasmosis is the most common endemic systemic mycosis in Latin America. The causal agent is Histoplasma capsulatum, a dimorphic fungus, which after being inhaled as microconidia turns into yeast when entering the human body. It is found on land, in plant debris, and can be isolated from the guano of bats and some birds. Its prevalence has increased due to the use of immunosuppressive drugs and the increasing cases of HIV. In immunocompetent hosts, the infection may be asymptomatic and self-limited. The most common manifestation is acute pulmonary infection. However, immunosuppressed or extremely aged patients can have a wide variety of clinical presentations and extrapulmonary involvement. Its clinical manifestations are diverse, including acute, subacute, and chronic forms, with varying degrees of severity. CLINICAL CASES: We present two clinical cases, one in an immunocompromised patient with HIV who debuted with a nasal ulcer and another immunocompetent patient with oral lesions; we discuss the main points to consider in this disease. CONCLUSIONS: We emphasize the importance of having present this disease even in immunocompetent patients, in whom, despite being infrequent, mucocutaneous lesions may appear due to this infection. [ABSTRACT FROM AUTHOR]

Copyright of Arquivos de Ciências da Saúde da UNIPAR is the property of Associacao Paranaense de Ensino e Cultura and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista de la Sociedad Lainoamericana de Dermatologia Veterinaria SLDV is the property of Sociedad Latinoamericana de Dermatologia Veterinaria SLDV and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista de Medicina y Cine / Journal of Medicine & Movies is the property of Ediciones Universidad de Salamanca and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Oral roflumilast is a phosphodiesterase-4 inhibitor approved for the prevention of exacerbations of chronic obstructive pulmonary disease and chronic bronchitis. In dermatology, topical roflumilast is authorized by the US Food and Drug Administration for the treatment of plaque psoriasis and mild to moderate seborrheic dermatitis. Several studies have described the off-label use of roflumilast in dermatology, including a randomized controlled trial showing its usefulness in the treatment of psoriasis; case reports and small series have also reported successful outcomes in hidradenitis suppurativa, recurrent oral aphthosis, nummular eczema, lichen planus, and Behçet disease. Roflumilast has a favorable safety profile, similar to that of apremilast, and it is considerably cheaper than new generation drugs and even some conventional immunosuppressants. We review the pharmacokinetics and pharmacodynamics of topical and oral roflumilast and discuss potential adverse effects and both approved and off-label uses in dermatology. Roflumilast is a promising agent to consider. Resumen: Roflumilast es un inhibidor de la fosfodiesterasa-4 aprobado de forma oral para la prevención de exacerbaciones en pacientes con enfermedad pulmonar obstructiva crónica y fenotipo de bronquitis crónica. En dermatología, el roflumilast tópico está aprobado por la Food and Drug Administration en psoriasis en placas y dermatitis seborreica leve/moderada. En cuanto a su uso fuera de indicación, hemos encontrado un ensayo clínico que avala la utilidad del roflumilast oral en psoriasis, así como pequeñas series de casos o casos clínicos aislados en hidradenitis supurativa, aftosis oral recurrente, eccema numular, liquen plano y enfermedad de Behçet. Su perfil de seguridad es favorable, similar al del apremilast, y su coste es considerablemente inferior a los de los fármacos de nueva generación, o incluso al de algunos inmunosupresores clásicos. Presentamos una revisión de roflumilast tópico y oral, en términos de farmacocinética y farmacodinámica, efectos adversos, usos dermatológicos aprobados y fuera de indicación. Roflumilast es un agente prometedor en dermatología.

Background and objective: Quality of professional life (QPL) is defined as a sense of well-being derived from a balance between the challenges of work and the resources available to deal with them. Impaired QPL can contribute to burnout. The aim of this study was to evaluate QPL in Spanish dermatologists using a validated questionnaire. Material and methods: We designed a cross-sectional study in which Spanish dermatologists were invited to complete an online questionnaire sent out by messaging applications. The dermatologists were asked to provide sociodemographic information, answer 3 open questions, and complete the 35-item Spanish QPL questionnaire (Spanish abbreviation, CVP-35). Results: We analyzed the information submitted by 106 dermatologists (62 women, 58%) with a mean age of 41 years (95% CI, 43.3-38.8 years). Women and department heads scored significantly higher in the workload domain of the questionnaire (P = .02 and P = .005, respectively). A heavy caseload was mentioned as the main factor contributing to impaired QPL and the main change in the wake of the COVID-19 pandemic. Conclusions: Female dermatologists reported heavier workloads. Heavy caseloads and more remote work were the main changes identified after the COVID-19 pandemic. Heavy caseloads have a significant impact on the QPL of dermatologists in Spain. Reducing caseloads would improve general job satisfaction and quality of care provision. Resumen: Antecedentes y objetivo: La calidad de vida profesional se define como el bienestar derivado del equilibrio entre las exigencias del ámbito laboral y los recursos para afrontarlas, el deterioro de la calidad de vida profesional puede contribuir en el síndrome de burnout o del profesional quemado. El objetivo de este estudio consiste en evaluar mediante cuestionario validado la calidad de vida profesional de los dermatólogos españoles. Material y métodos: Se diseñó un estudio transversal que incluyó dermatólogos españoles que respondieran a un formulario autoadministrado enviado a través de aplicaciones de mensajería online. El formulario incluyó datos sociodemográficos, 3 preguntas de respuestas abiertas y el Cuestionario de Calidad de Vida Profesional (CVP-35). Resultados: Se incluyó a 106 participantes en este estudio, siendo un 58% (62/106) mujeres. La edad media fue de 41 años (intervalo de confianza [IC] del 95%: 43,3-38,8). Las puntuaciones para el dominio «carga de trabajo» de CVP-35 fueron superiores en las mujeres (p = 0,02) y en los jefes de servicio (p = 0,005). La presión asistencial fue el tema tratado con más frecuencia como factor limitante de la calidad de vida laboral, y el principal cambio identificado tras la pandemia de COVID-19. Conclusiones: En nuestro estudio las mujeres refirieron una mayor carga de trabajo. El incremento de carga asistencial y de trabajo a distancia fueron los principales cambios por la pandemia de COVID-19. La presión asistencial es una gran limitante de la calidad de vida profesional de nuestros compañeros, reducirla mejoraría la satisfacción diaria y la calidad asistencial.

Foundation: basal cell carcinoma is a very common malignant tumor in humans. It is considered locally invasive, also aggressive and destructive. Objective: to show the behavior of patients with basal cell carcinoma diagnosed by dermoscopy in dermatology clinic of the Miguel Enríquez University Hospital, between June 2020 and May 2021. Method: a descriptive, cross-sectional study was carried out to show the behavior of patients with basal cell carcinoma who attended the dermatology consultation at the Miguel Enríquez University Hospital from June 2020 to May 2021. The universe of study was made up of patients older than 18 years who presented one or more presumptive lesions of basal cell carcinoma less than 3 cm in diameter. The variables used were: age, sex, skin phototype, clinical forms, dermoscopic patterns, topography of the lesion, occupation related or not to sun exposure. We worked with absolute frequencies, percentage, mean, standard deviation, maximum and minimum values, the ratio, chi-square and student's t tests, with significance p≤0.05. Results: it prevailed in the elderly (66.4±14.9 years), in men (54.1 %), with phototype 2 (57.8 %), and in the nose 33.9 %. The nodular form was more frequent (41.3 %), occupation exposed to the sun (66.9 %), average size of the lesion 1.4 cm. Dermoscopy showed a predominance of arborizing vessels (73.4 %). By histology, 90.8 % of the cases were confirmed. Conclusions: the elderly prevailed among the patients, with phototype 2. The nodular form was more frequent, the average size of the lesion was 1.4 cm. Dermoscopy showed a predominance of arborizing vessels. Dermoscopy turned out to be a necessary tool for systematic use in dermatology.

O Complexo Granuloma Eosinofílico (CGE) é uma síndrome comum em gatos e rara em cães, a qual apresenta três tipos de lesões (úlcera indolente, placa eosinofílica e granuloma eosinofílico) que podem acometer a pele, a cavidade oral e os lábios. É frequentemente associado a alergopatias e acompanhado de Dermatite Miliar Alérgica (DMA) em alguns casos. Este trabalho teve como objetivo elucidar as diferentes apresentações clínicas do CGE e relatar três casos ocorridos em felinos atendidos no Hospital Veterinário da Universidade Metodista de São Paulo, em São Bernardo do Campo, São Paulo, entre fevereiro de 2022 e fevereiro de 2023. Os diagnósticos de CGE de tais casos foram alcançados, principalmente, pela abordagem clínica, os tratamentos foram eficazes e os prognósticos favoráveis.

O câncer é caracterizado pela multiplicação desordenada de células, apresentando grande incidência no mundo - 18,1 milhões. A radioterapia constitui método utilizado em mais de 50% dos casos, entretanto, esse meio de tratamento promove também efeitos adversos, dentre eles a radiodermatite. Tendo em vista o enfermeiro como componente relevante da equipe multidisciplinar de saúde e profissional que acompanha o paciente em todas as etapas da doença, este trabalho objetiva: descrever os cuidados de enfermagem na prevenção e tratamento de afecções dermatológicas ocasionadas pela radioterapia em trabalhos publicados no Brasil entre os anos de 2016 a 2022. O método utilizado foi a revisão integrativa, utilizando o booleano “AND” nas bases de dados GOOGLE ACADÊMICO, LILACS, SCIELO, utilizando-se das palavras chaves: Enfermagem, Radioterapia, Pele. O resultado desse estudo permitiu analisar 390 artigos relacionados ao tema, porém foram excluídos 370 artigos por se apresentarem como língua estrangeira, por não estar no ano referido, por apresentar trabalhos iguais, ou por não atenderem aos anseios da pesquisa. A partir dos 20 artigos formularam-se três tópicos para redação das informações: “Prevenção e tratamento das radiodermites, educação em saúde e para o autocuidado; manejo da dor e segurança do paciente”. A pesquisa corrobora o importante papel da enfermagem na prevenção e tratamento do paciente portador de radiodermite, ainda contando com outras táticas que elevem a promoção de saúde e qualidade de vida.

Copyright of Arquivos de Ciências da Saúde da UNIPAR is the property of Associacao Paranaense de Ensino e Cultura and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Physiological changes are responsible for the appearance of aesthetic dysfunctions in the maternal body, among which the following stand out: the appearance of stretch marks, geloid fibroedema, fluid retention, varicose veins, acne and melasma. The skin is mainly affected due to hormonal instability, resulting in the development of changes that are characteristic of the gestational period. The objective of this research was to review the main dermatofunctional physiotherapeutic interventions used in aesthetic dysfunctions acquired during pregnancy. This is an integrative review of the literature. The electronic databases used to carry out the work: PubMed and Google Scholar between the years 2018 and 2023. In the results, 28 articles were selected due to the relevance of which aesthetic dysfunctions occur with greater prevalence during pregnancy and which treatments could be used in physiotherapeutic care. It can be concluded from the study carried out that prevention is the main objective for aesthetic dysfunctions acquired during pregnancy. [ABSTRACT FROM AUTHOR]

Copyright of Diversitas Journal is the property of Diversitas Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: Teenagers’ Quality of Life (T-QoL) is an age-specific measure to assess QoL of teenagers suffering from different skin diseases. A validated Spanish language version is lacking. We present the translation, cultural adaptation and validation of the T-QoL into Spanish. Methods: A prospective study with 133 patients (between 12 and 19 years old), attended at the dermatology department of Toledo University Hospital, Spain (September 2019–May 2020), was carried out for the validation study. The International Society for Pharmacoeconomics and Outcomes Research (ISPOR) guidelines were used for the translation and cultural adaptation. We evaluated the convergent validity with the Dermatology Life Quality Index (DLQI), the Children's Dermatology Life Quality Index (CDLQI) and with a Global Question (GQ) on self-assessed disease severity. We also analysed internal consistency and reliability of the T-QoL tool and confirmed its structure with a factor analysis. Results: Global T-QoL scores significantly correlated with the DLQI and the CDLQI (r = 0.75) and with the GQ (r = 0.63). The confirmatory factor analysis showed optimal fit for the bi-factor model and an adequate fit for the correlated three-factor model. Reliability indicators were high (Cronbach's α = 0.89; Guttman's Lambda 6 index = 0.91; Omega ω = 0.91) and test–retest showed a high stability (ICC = 0.85). The results were consistent with those found by the authors of the original test. Conclusion: Our Spanish version of the T-QoL tool is valid and reliable to assess QoL of Spanish-speaking adolescents with skin diseases. Resumen: Antecedentes: Teenagers’ Quality of Life (T-QoL) es un cuestionario de calidad de vida específico para adolescentes con enfermedades cutáneas. Hasta el momento, no existe ningún método validado para este fin en español, por lo que presentamos la traducción, adaptación cultural y validación del T-QoL al español. Método: Se diseñó un estudio prospectivo con 133 pacientes (entre 12-19 años), atendidos en el Servicio de Dermatología del Hospital Universitario de Toledo, España (septiembre 2019-mayo 2020). Para la traducción y adaptación cultural se utilizaron las guías de la Sociedad Internacional de Farmacoeconomía e Investigación de Resultados (ISPOR). Se evaluó la validez convergente con el Índice de Calidad de Vida en Dermatología (DLQI), el Índice de Calidad de Vida en Dermatología Infantil (CDLQI) y con una Pregunta Global (GQ) sobre la gravedad de la enfermedad autoevaluada. También se analizó la consistencia interna y la fiabilidad de la herramienta T-QoL, y se confirmó su estructura con un análisis factorial. Resultados: Las puntuaciones globales de T-QoL se correlacionaron significativamente con el DLQI y el CDLQI (r = 0,75) y con la GQ (r = 0,63). El análisis factorial mostró un ajuste óptimo para el modelo bifactorial y un ajuste adecuado para el modelo de 3 factores correlacionado. Los indicadores de fiabilidad fueron altos (α de Cronbach = 0,89; índice Lambda 6 de Guttman = 0,91; Omega ω = 0,91) y el test-retest mostró una alta estabilidad (ICC = 0,85). Los resultados fueron consistentes con los encontrados por los autores de la prueba original. Conclusiones: La versión española del T-QoL es un cuestionario válido y fiable para evaluar la calidad de vida de adolescentes hispanohablantes con enfermedades cutáneas.

Introducción: La lipoproteinosis o enfermedad de Urbach Wiethe, es una genodermatosis, de origen genético y patrón de transmisión autosómico recesivo, sin predilección de sexo. Caracterizado por diversos grados de depósitos intercelulares de material hialino en la piel, membranas mucosas y órganos internos, lo que condiciona infiltración y engrosamiento de órganos afectados. El curso es lento y carácter benigno. Caso clínico: Se presenta el caso de una niña de 6 años de edad, quien consulta por piel seca y ronquera desde los 2 años de edad. Se realiza el diagnóstico clínico e histopatológico. Evolución: Se inicia tratamiento con Pentoxifilina observándose luego de 6 meses mejoría significativa de las lesiones Conclusiones: Se evidencia la eficacia y la seguridad de la pentoxifilina como terapia complementaria en pacientes pediátricos con diagnóstico de lipoidoproteinosis.

Los autores han efectuado una investigación terapêutica, clínica e histopatológica mediante el empleo tópico del 5-Muorouracilo sobre casi 1.000 pacientes. En 182 casos de psoriasis, los resultados no reflejan más que una observación experimental sin arribar aún a conclusiones definitivas. Han podido demostrar la excelente actividad terapêutica selectiva de dicho fármaco en el tratamiento curativo de las manchas, queratosis y verrugas seborreicas y queratosis seniles, queratoacantoma, epitelioma pagetoide, numerosos casos de epitelioma basocelular, Bowen, hidroarsenicismo crônico regional endêmico, estados pre-epiteliomatosos peneanos, queratodermias e hperplasia psêudoepiteliomatosa. En un cierto número de casos de epiteliomas espinocelulares y xeroderma pigmentoso, los resultados fueron también notables. La excelente tolerância para un procedimiento con determinada acción cáustica, unida a la calidad de los resultados, hacen considerar al 5-Fluorouracilo como un agente que se incorpora en forma definitiva al tratamiento de procesos cutâneos precisos. Fosee apreciables ventajas sobre otros métodos que, sih desplazarlos por ser de reconoçida utilidad, le permiten tomar uma buena parte de los casos clinicos que antes eran tributários exclusivamente de aquellas técnicas. Es así que en el tratamiento de manchas, queratosis, verrugas seborreicas y solares, y epitelioma plano superficial pagetoide la actividad de la droga en ensayo representa un efectivo y probado elemento terapêutico que tiene las siguientes ventajas: a) Efectividad traducida por la curación clínica e histológica. b) Sencillez de aplicación. c) Posibilidad de aplicaciones múltiples reguladas de acuerdo con la necesidad. d) Probable empleo dei material por técnicos auxiliares, familiares y aún por los mismos pacientes, previamente entrenados, cuando el número de lesiones es muy grande e cuando por razones de distancia o de tareas absorbentes tal conducta resulte una solución de emergencia. Esta metodologia puede resultar selectiva en los lugares del pais alejados de los centros urbanos. f) Ausência o escasez de acción agresiva sobre la piei normal circundante. g) Muy bajo número de reacciones por contacto o sensibilización. En el xeroderma pigmentoso la droga ofrece grandes posibilidades para el control de los epiteliomas, queratosis, verrugosidades, etc. Cremos que la quimioterapia local está destinada a difundirse entre los dermatólogos como método de elección que podrá completarse con otros enfoques de tratamiento local o sistêmico. El uso de ungüentos terapeuticamente activos adcionados de 5-Fluorouracilo representa un progreso dentro de la medicación tópica en el caso de queratodermias rebeldes de cualquier etiologia (inclusive en algunas genodermatosis). Merece profundizarse la investigación em cuanto a Ias posibilidades del 5-Fluorouracilo en la medicación tópica en casos de formas localizadas de psoriasis. La hiperplasia pseudoepiteliomatosá en todas sus formas inclusive en la papilomatosis florida, puede hallar en el 5-Fluorouracilo, por si mismo o en ocasiones unido a la medicación sistêmica, una solución a dificilísimos problemas planteados hasta la actualidad.

Objective: This was a retrospective analysis of the epidemiological and clinical profile of ten main skin neglected tropical diseases (NTDs) and appraisal of the role of dermatologists in the control and elimination of those diseases. Methods: Analysis of routine data and special investigations carried out by the Ministry of Health between 2017 and 2021, and internet search of published information on skin NTDs in Angola. Results: Except for yaws, all skin NTDs under review remain endemic. Previously unknown foci of Buruli ulcer (BU), cutaneous leishmaniasis (CL), and guinea worm disease (GWD) were detected in recent years. Leprosy, onchocerciasis, lymphatic filariasis, scabies, and snake bites are endemic countrywide. Weak laboratory services are a major constraint to confirm clinically suspected cases. The growing collaboration between public health workers, family doctors, and dermatologists is strengthening integrated approaches in NTDs control and elimination programs. Conclusions: The elimination of leprosy, BU, CL, and GWD as public health problems does not warrant the total interruption of their transmission chain over time. Effective case diagnosis and epidemiological surveillance are key strategies to control and eliminate skin NTDs. In addition to patient centered disease diagnosis and management, dermatologists must actively support field investigations, innovative training programs, and advocacy on skin NTDs. [ABSTRACT FROM AUTHOR]

The Polish Dermatological Society was founded in February 1920 by Franciszek Krzyształowicz (1868-1931), Robert Bernhardt (1874-1950), Roman Leszczyński (1873-1940), Jan Lenartowicz (1877-1959) and Franciszek Walter (1885-1950). For 100 years of the existence of the Polish Dermatological Society, the most important goal was to build cooperation and the best possible, science-based, quality of dermatology in Poland, as well as building a favorable image of Polish dermatology and Polish dermatologists in the world. The Society now has over 2,600 members, the most in the history of our Society. The Polish Dermatological Society, was created by people with a passion for dermatology and cooperation. Now, after it was developed by several generations dermatologists we can look with optimism into the next 100 years. [ABSTRACT FROM AUTHOR]

The generation of cell blocks (CB) obtained from ultrasound-guided fine needle aspiration biopsies (USFNAB) is a well-established technique in breast and thyroid pathology, but is rarely used in dermatology. We reviewed CBs obtained from USFNAB of skin lesions, which were categorized as malignant skin tumors, benign skin tumors, inflammatory skin tumors or deposit skin diseases. The diagnostic yield of each category was compared to histopathology. The USFNAB of 51 skin lesions was processed into CBs. There was overall agreement between histopathology and CBs in 84.31% of cases. Diagnostic group concordance for benign, malignant as well as inflammatory and deposit skin lesions were 69.2%, 93.7% and 86.3% respectively. Cell block generation from USFNAB aspirates of skin lesions should be considered as part of the dermatologic diagnostic armamentarium. Further experience is needed to better understand for which types of dermatologic lesions it would be clearly indicated. Resumen: La generación de bloques celulares (CBs) obtenidos a partir de punción-aspiración con aguja fina guiada por ultrasonido (USFNAB), es una técnica bien establecida en patología mamaria y tiroidea, pero rara vez se utiliza en dermatología. Revisamos los CBs obtenidos por USFNAB de lesiones cutáneas, que se clasificaron como tumores cutáneos malignos, tumores cutáneos benignos, tumores cutáneos inflamatorios o enfermedades cutáneas por depósito. El rendimiento diagnóstico de cada categoría se comparó con la histopatología. La USFNAB de 51 lesiones cutáneas se procesó en CBs. Hubo concordancia global entre la histopatología y los CBs en el 84,31% de los casos. La concordancia entre histopatología y CBs para lesiones cutáneas benignas, malignas e inflamatorias y por depósito fue del 69,2, 93,7 y 86,3%, respectivamente. La generación de CBs a partir de USFNAB de lesiones cutáneas debe considerarse como parte del arsenal diagnóstico dermatológico. Se necesita más experiencia para comprender mejor para qué tipos de lesiones dermatológicas estaría claramente recomendado.

Introdução: A obesidade é condição prevalente na rotina da assistência médica em todos os níveis da atenção à saúde, entretanto, existem poucos estudos nacionais sobre as dermatoses mais frequentes neste público. Objetivo: Este trabalho buscou avaliar a condição cutânea da população de obesos e comparar com pacientes não obesos, procedentes do sistema público de saúde. Materiais e Métodos: Estudo quantitativo transversal onde foram avaliados 60 adultos com sobrepeso e obesidade (IMC ≥ 30 kg/m2) e 60 com IMC normal (18,5 - 24,9 kg/m2) de ambos os sexos dos ambulatórios de clínica médica durante o segundo semestre de 2015, selecionados aleatoriamente, separados em grupos de caso e controle. Resultados: Predominaram pacientes do sexo feminino (75%), na faixa etária de 56,3 anos, brancas, sedentárias, com ensino fundamental incompleto. As três dermatoses mais prevalentes no grupo dos casos foram estrias (57,4%), e a região do corpo mais acometida foi o abdômen, com 82,9%; nevo rubi (52,5%) e insuficiência venosa superficial (41%). Discussão: Os achados apontam alta frequência de dermatoses nos obesos. Estes pacientes necessitam de acompanhamento adequado visto que existe a possibilidade de prevenção das alterações dermatológicas e sistêmicas. Conclusão: Todos os médicos precisam ser treinados para o diagnóstico dessas afecções. Casos com necessidades clínicas cirúrgicas ou cosmiátricas específicas devem ser encaminhados para manejo dermatológico visando reduzir riscos, danos e desconfortos.

Introduction and Objective: The present study on atopic dermatitis (AD) in Portugal aims to characterize patient needs and discuss measures to improve health care in dermatology, particularly in cases of moderate to severe disease. Methods: The study was conducted in three phases--(1) data collection on the patient access to healthcare and subsequent analysis; (2) critical evaluation of the data in individual interviews with dermatologists and one pediatrician; and lastly, (3) data discussion in consensus meetings to validate the existing care capacity in dermatology, to identify gaps in care for patients with AD and to define mitigation strategies. Results: In Portugal, it is estimated that AD affects ~ 360,000 patients, 70,000 of whom have moderate to severe disease. Healthcare capacity analysis confirmed that the private system plays an important role in the management of AD. It is estimated that 30% of patients rely solely on the Portuguese public health service. Nevertheless, patients with moderate to severe disease can only access advanced targeted therapies from public healthcare providers. Analysis of public care capacity in dermatology shows relevant gaps in the referral system, the geographical coverage of specialized centers, the number of specialists and high waiting times for first appointments. Considering the negative impact of the disease on patients' quality of life, 86% of patients with AD use private settings to better manage their disease. Conclusion: In conclusion, private setting bridges the gaps in public health care capacity in dermatology, and therefore, it is crucial for patients with AD. However, a major limitation is the lack of reimbursement for advanced targeted therapies recommended for moderate to severe AD when they are prescribed in a private setting, thus compromising patient access to these therapies. A possible strategy could be to extend the prescription of these therapies to a private setting based on a reimbursement model similar to that outlined in Act 48/2016 of 22 March. [ABSTRACT FROM AUTHOR]

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Background: the purpose of photoprotection is the prophylaxis and repair of damage caused by solar radiation. Objective: to determine the level of knowledge about photoprotection from patients treated for skin cancer at the University Polyclinic "Aquiles Espinosa Salgado" from Las Tunas municipality, between October 2021 and October 2022. Methods: a prospective, descriptive study was carried out in 910 patients with manifestations of any form of photo damage, attended in the office and during the period of time defined above. The variables studied included knowledge about causes of skin cancer and other damages caused by the sun, nevi alarm elements, sun photoprotection measures, beneficial and harmful effects of the sun, reasons for not regularly using photoprotection and sources of information for such knowledge. Results: the total number of patients recognized what causes skin cancer and other sun damages, 94.2 % has knowledge about the warning elements of nevi and 90.7 % about sunburn. All patients knew about photoprotection measures. 88.1 % reported that products useful for protection are not available on the formal domestic market. 42.7 % recognize that the sun is involved in the synthesis of vitamin D as a beneficial effect and 94.1 % as a cause of premature aging. The main channels for obtaining information were the mass media (89.7 %) and health personnel (80.8 %). Conclusions: most patients have adequate knowledge about photoprotection.

Objetivo: Conhecer o perfil epidemiológico e social dos pacientes com suspeita de câncer de pele, atendidos no Ambulatório de Dermatologia de Hospital Público de Brasília, Distrito Federal, Brasil. Método: Estudo descritivo, quantitativo, retrospectivo, de corte transversal. Utilizou-se um formulário para sistematizar informações dos pacientes atendidos e encaminhados para cirurgia por suspeita de câncer de pele. A análise estatística e mensuração da incidência da ocorrência de câncer de pele foi realizada pelo Programa SAS (Statistical Analysis System Inc, Cary, Carolina do Norte). Resultados: Foram selecionados 180 pacientes a partir dos critérios de inclusão e exclusão. Destes, 55% corresponderam ao gênero feminino e 43,9% ao gênero masculino, tendo a maioria (28,3%) idade entre 70 a 80 anos. Em relação à profissão/grau de escolaridade, 55,6% não tinham informações registradas e constatado grau de escolaridade dos demais na seguinte composição: 1º grau incompleto (8,9%), 2º grau incompleto (5,6%) e apenas 1,1% com ensino superior completo. O Carcinoma Basocelular (67,2%) revelou-se o mais incidente, com lesões na face (65,6%) seguida dos membros superiores (13,3%). Conclusão: Constatou-se uma prevalência considerável de fragilidade em idosos com Doença de Pele (DP), cujas variáveis de idade, gênero e localização das lesões cancerígenas podem interferir na piora da capacidade funcional e, consequentemente, da qualidade de vida dessa população. É importante que os profissionais de saúde realizem promoção de saúde sensibilizando os pacientes quanto aos possíveis meios para proteção da pele e acesso em tempo oportuno para diagnosticar lesões.

En la actualidad, se dispone de múltiples tratamientos para las heridas crónicas, dentro de ellos la miel por sus beneficios antisépticos. El objetivo del ensayo busca describir los beneficios de la miel de abejas en el tratamiento de heridas crónicas. Se concluye que la miel de abejas puede ofrecerse como alternativa en el tratamiento de quemaduras, heridas y úlceras debido a su beneficiosa curación. Mejora el resultado estético de la herida dejando menos cicatriz. Disminuye el impacto sobre la imagen corporal de este tipo de lesiones. Supone un tratamiento más barato y eficaz. Puede mejorar la calidad en la asistencia sanitaria, además de reducir el número de procedimientos innecesarios, disminuir la variabilidad clínica y unificar los criterios de actuación entre los profesionales. Currently, there are multiple treatments for chronic wounds, including honey for its antiseptic benefits. The objective of the essay seeks to describe the benefits of honey in the treatment of chronic wounds. It is concluded that bee honey can be offered as an alternative in the treatment of burns, wounds and ulcers due to its beneficial healing. It improves the aesthetic result of the wound, leaving less scarring. Reduces the impact on body image of this type of injury. It is a cheaper and more effective treatment. It can improve the quality of health care, in addition to reducing the number of unnecessary procedures, reducing clinical variability and standardizing action criteria among professionals.

Introducción. Entre el 80 y el 95 % de los pacientes infectados por el virus de inmunodeficiencia humana (HIV) desarrollan manifestaciones en la piel que sirven como marcadores de su estado inmunológico. Objetivos. Describir las manifestaciones dermatológicas y los factores clínicos y sociodemográficos de los pacientes hospitalizados con diagnóstico de HIV y su correlación con el recuento de linfocitos T CD4. Materiales y métodos. Se hizo un estudio observacional de corte transversal y retrospectivo a partir del registro de las historias clínicas de 227 pacientes mayores de edad con diagnóstico de HIV, evaluados por dermatología en un hospital de Medellín, Colombia. Resultados. Los 227 registros daban cuenta de 433 manifestaciones dermatológicas, el 64,4 % de ellas infecciosas. Las tres manifestaciones más frecuentes fueron candidiasis oral, condilomas acuminados y reacciones a medicamentos. Se encontró una relación estadísticamente significativa entre el virus del herpes zóster (HZ) diseminado y la sífilis secundaria, con un recuento de CD4 entre 200 y 499 células/mm3 (p=0,04 y 0,028, respectivamente), y entre la candidiasis oral y un recuento de CD4 menor de 100 células/mm3 (p=0,008). Conclusiones. La relación entre el herpes zóster diseminado y un recuento de CD4 entre 200 y 499 células/mm3 sugiere que, a pesar de los recuentos altos, se pueden presentar formas graves de la enfermedad debido a una posible disfunción de las células T y el agotamiento del sistema inmunológico. La relación entre la candidiasis oral y un recuento de CD4 menor de 100 células/mm3 plantea la posibilidad de considerar esta infección micótica como un marcador importante de debilitamiento inmunológico de los pacientes con HIV.

Introduction: Undergraduate dermatology courses vary in the nearly 50 Spanish medical faculties that teach the subject. This study aimed to describe the characteristics of these courses and to analyze whether the weight assigned to dermatology topics reflects the caseloads of primary care physicians and general dermatologists in the Spanish national health system. Material and methods: Cross-sectional study of syllabi used in Spanish medical faculties during the 2021–2022 academic year. We determined the number of teaching hours in public and private university curricula and compared the weight of dermatology topics covered to the dermatology caseloads of primary care physicians and general dermatologists as reported in published studies. Results: Most medical faculties taught dermatology for one semester. The median number of credits offered was 4.5. On average, lectures covered 24 theoretical topics, and seminars and workshops covered 9 topics. We identified a clear disparity between the percentage of time devoted to dermatology topics in course lectures and the skin conditions usually managed in primary care and general dermatology practices. Discussion: The skin diseases most commonly treated by primary care physicians and general dermatologists are underrepresented in the curricula of Spanish medical faculties. The topics that should be given more weight in syllabi, or recovered for inclusion in dermatology courses, should be re-examined. Our findings show that the topics that ideally should be emphasized more are types of dermatitis, infectious skin diseases, acne, psoriasis, rashes, and the differential diagnosis of benign and malignant neoplasms. There should be additional support for the theoretical teaching of these topics. Resumen: Introducción: La docencia de pregrado de Dermatología varía entre las casi 50 facultades de Medicina españolas. El presente estudio pretende describir las características de las asignaturas y analizar si la carga lectiva de los temarios se ajusta a la casuística de los médicos de Atención Primaria y dermatólogos generales del sistema de salud español. Material y método: Estudio de corte transversal realizado en 2021-2022. Se recabaron datos de universidades a partir de las guías docentes. Se comparó la carga docente de una universidad pública y otra privada con la carga asistencial de médicos de familia y dermatólogos a partir de estudios previos. Resultados: La mayor parte de las facultades imparten Dermatología como asignatura semestral, con una mediana de 4,5 créditos, con una media de 24 temas teóricos y 9 temas en seminarios y talleres. Existe una clara divergencia entre la carga docente relativa de los temas teóricos y la carga asistencial por enfermedades cutáneas en Atención Primaria y Dermatología general. Discusión: La carga lectiva infrarrepresenta en gran medida las enfermedades cutáneas más comúnmente consultadas en Atención Primaria y Dermatología general. Resulta oportuno reevaluar qué contenidos deben adquirir o recuperar una mayor representación en la carga docente de la asignatura de Dermatología. Con base en los resultados obtenidos, consideramos óptimo incrementar, idealmente mediante metodologías de apoyo a la docencia teórica, la carga docente referida a cuadros de dermatitis, dermatosis infecciosas, acné, psoriasis, urticaria y, finalmente, las neoplasias benignas y su diagnóstico diferencial con las malignas.

Background: Pilomatricomas are neoplasms of hair follicles, located in the hair bulb, and the incidence is uncommon in the clinical-surgical clinical routine of dogs and cats. It commonly affects adult animals, with no predisposition to sex or race, and is mainly located in the neck, back, and tail region. The diagnosis is made by histopathological examination, where cells are observed in which their nucleus does not stain with hematoxylin and eosin - empty nucleus. The present work aimed to report a case of benign pilomatricoma since it is a rare condition in dogs and cats and, consequently, there is little information in the literature. Case: A 6-year-old male Shih-Tzu dog, not submitted to surgical contraception, weighing 6.9 kg, was treated at the Veterinary School Hospital (HVE) of the North Parana State University (UENP), Bandeirantes, PR, Brazil, with a history of nodules in the tail region, lasting 6 months. On physical examination, no changes were identified in the patient's physiological parameters. However, the presence of neoformations in the distal and medial region of the tail, similar to a nail, adherent, non-ulcerated and non-alopecic, and absence of pruritus or self-mutilation were identified. Vaccination and deworming were updated. Hematological examination, serum biochemicals (urea, creatinine, alanine aminotransferase, alkaline phosphatase, and albumin), and abdominal ultrasound showed no changes. According to the clinical and laboratory signs, it was decided to perform an excisional biopsy, using a caudectomy, for subsequent histopathological examination. The specimens were fixed in 10% formaldehyde and sent for histopathological examination. Histological examination was compatible with benign pilomatricoma. Postoperatively, cephalexin, dipyrone, tramadol hydrochloride, and meloxicam were prescribed, surgical wound cleaning, and the use of an Elizabethan collar until the suture was removed. After 10 days of the surgical procedure, the patient was asked to remove the sutures, and no changes were identified regarding the physiological parameters and blood count. Discussion: Pilomatricomas are commonly benign neoplasms arising from the germ cells of the follicular matrix. They present dermal or subdermal forms, with several cystic structures which are surrounded by keratinocytes, similar to the matrix cells of an anagen hair follicle, more keratinized and firmer areas, corroborating the results of the present report. In the ultrasound examination, the presence of intra-abdominal metastases was not identified, which is consistent with the literature, since in this type of neoplasm it is not common to identify foci of intra-abdominal and thoracic metastases. In the present report, immunohistochemistry was not used, even though it is used to differentiate follicular neoplasms from pilomatricomas. However, histopathological examination is considered the best method for the definitive diagnosis of pilomatricomas in dogs. It was concluded that the surgical treatment through excisional biopsy, with safety margins of 2 cm, was effective as a therapeutic method in the case of benign pilomatricoma, and the definitive diagnosis must be made through histopathological examination. [ABSTRACT FROM AUTHOR]

Dapsone was discovered in 1908, it is a drug prescribed in inflammatory and infectious diseases. It is the first line treatment mainly in skin diseases with an accumulation of neutrophils and eosinophils. It is metabolized by two enzymatic pathways N-acetylation and N-hydroxylation. It has adverse haematological, skin, gastrointestinal, kidney and nervous system effects. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To recount the immunopathogenesis of SARS-CoV-2 infection and its skin manifestations. METHODOLOGY: A literature search was performed in the MEDLINE database through the PubMed search engine with the terms "SARS-CoV-2", "SARS-CoV", "Covid-19", "Skin", "Dermatology", "Cutaneous", "Immunology", "Immune". RESULTS: In COVID-19 disease, multiple pathophysiological mechanisms are described, among which the binding of the virus to the angiotensin-converting enzyme 2 (ACE2) receptors in endothelial cells that facilitate the involvement of adjuvant skin, the depletion of T lymphocytes (LT), the generation of a cytokine storm and the activation of macrophages, among others. CONCLUSIONS: An update is made on the knowledge about the immunopathogenesis of COVID-19 and its main cutaneous manifestations, highlighting the need to carry out more research studies that allow a better understanding of it and the creation of possible therapeutic targets. [ABSTRACT FROM AUTHOR]

Objective: To determine the clinical and socio demographic features of patients attended at a public hospital in Trujillo, Peru. Methods: A cross-sectional study that included 385 skin biopsies obtained from the archives of the Pathology Department and from the clinical charts of these patients at Hospital Belen in Trujillo from January 2018 to December 2019 was carried-out. Results: The most common entity was basocellular carcinoma located on the face in patients above 60 years of age. The second most common entity was epidermoid carcinoma. Malignant lesions affected 66.7% of patients between 55 and 79 years of age with a mean of 67 years. Most of the patients were unemployed males (65.8%). The most common benign lesion was the epidemic inclusion cyst mostly in the trunk among males from 20 to 24 years of age. The second most common benign lesion was the pilomatrixoma mostly located in the upper limbs of patients below 10 years of age. Benign lesions affected the 59.6% of the sample between 30 to 54 years of age with a mean of 44 years, mostly among housewives. Most of the patients came from districts of Trujillo. The causal agent was not identified. Conclusions: In mestizo patients both benign and malignant lesions had a clinical presentation similar as reported in the literature regarding location, age and gender distribution. Occupation and precedence were not contributory. [ABSTRACT FROM AUTHOR]

Background: Toxic Epidermal Necrolysis (TEN) is a dermatological emergency characterized by generalized epidermal necrolysis, causing peeling of the skin, which becomes susceptible to serious infections. It presents multisystemic involvement, with high morbidity and mortality. The management of TEN is multifaceted, and begins with identifying and removing the causative agent. Identification of the agent depends on a complete clinical history, as symptoms generally present within eight weeks of initiating drug therapy. Suspending the causative drug is fundamental in the evolution of the pathology and clinical success depends, mainly, on supportive treatment, to avoid complications, such as sepsis. Aim: To report a single case of NET seen in our service. Method: This is a case report of a patient treated at the Hospital Universitário São Francisco na Providência de Deus - HUSF, located in the city of Bragança Paulista - SP, Brazil. Case Report: The case reported in this paper was a 33-year-old male patient, with no known comorbidities, who presented with pruritic and painful erythematous vesicular lesions, initially in the groin region and upper limbs, with progression to the trunk and lower limbs, associated with fever, ocular hyperemia and conjunctivitis. The patient also had anemia, elevated CRP and hypoalbuminemia, but with normal renal and hepatic function. Serologies for HIV and syphilis were performed, with positive results. During hospitalization, the lesions rapidly worsened, with mucosal involvement, skin peeling and epidermal detachment, raising the suspicion of TEN. The patient was admitted to the ICU due to generalized involvement, newly diagnosed HIV and risk of sepsis. Treatment included isolation, intensive skin care, cyclosporine, benzathine penicillin due to the diagnosis of syphilis and antiretroviral therapy for HIV, leading to significant improvement. After 11 days of hospitalization, the patient was discharged from the hospital and maintained outpatient follow-up with an infectious disease specialist and dermatologist. Conclusion: This paper highlighted a clinical case that illustrates the diversity of scenarios in which TEN can occur, emphasizing the importance of early recognition, multidisciplinary treatment and appropriate management to improve the outlook for patients, especially those who are immunosuppressed. Furthermore, awareness about TEN, especially in relation to specific medications, is crucial to ensure effective management and follow-up of patients, especially those with underlying health conditions. [ABSTRACT FROM AUTHOR]

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The Ehlers-Danlos syndrome (EDS) consists of a group of diseases characterized by defective collagen production or failure in its organization, resulting in changes in the strength and extensibility of connective tissue. This report describes the dermatological and histological findings observed in a 3-month-old crossbreed cat with rupture and detachment of skin in the thoracic limb and rupture of the skin in the cervical region. Upon dermatological examination, the cat presented fragile and hyperextensible skin in the cervical region and a skin extensibility index of 21%. Histopathological evaluation of the skin specimens revealed evident disorganization of collagen bundles in dermis and in the Masson's trichrome staining, follicular dysplasia was found. The presumptive diagnosis of EDS was made based on the clinical and histopathological findings. Sanger sequencing did not detect any mutated alleles for the c.3420delG mutation in COL5A1 gene, which was an autosomal dominant mutation previously been associated with Ehlers-Danlos syndrome in cats. The absence of this mutation in the reported cat suggests that other mutation may also be responsible for the development of cutaneous asthenia in this or maybe other genes related to collagen metabolism. [ABSTRACT FROM AUTHOR]

Background: Chronic Urticaria (CU) is a debilitating disease whose treatment is mainly symptomatic. UCREX study aimed to identify CU patients’ profile, disease management and quality-of-life (QoL) in daily clinical practice in Spain. Methods: Observational, 12-months prospective, multicenter study, included de novo or established CU patients attending to dermatology/allergy consultations in 39 Spanish hospitals. Main variables: Urticaria Activity Score (UAS), UAS over 7 days (UAS7). Secondary variables: CU-QoL Questionnaire (CU-Q2oL), EuroQol-5 dimensions (EQ-5D), Medical Outcomes Study Sleep (MOS-Sleep) scale, Hospital Anxiety and Depression Scale (HADS). Results: 361 patients included. Of them, 176 (48.8%) considered for the main objective analysis. Mean age (SD) of 46.6 (14.2) years and 71.8% women. The year prior to inclusion, most patients (57.1%) were treated with non-sedating H1-antihistamines (NS-H1AH). At baseline, mean (SD) 3.6 (6.8) visits were registered to primary care. Mean (SD) UAS7 at baseline was 14.3 (11.0) and CU-Q2oL 24.1 (17.0) which tended to improve by 8.6 (9.7) and 13.9 (15.0), respectively, at 12-months. MOS-Sleep and EQ-5D remained steady during the study, except pain/discomfort and anxiety/depression which went from 58.7% and 49.6% to 29.6% and 26.9%, respectively. At baseline, HADS showed a mean (SD) anxiety of 8.7 (4.5) and depression 5.1 (4.4), decreasing to 7.0 (4.3) and 4.7 (4.3), respectively, at 12-months. Conclusions: Although most CU patients are treated with NS-H1AH, disease activity is still important, negatively affecting patients’ QoL, work activity and healthcare resources use. An appropriate disease management could be the basis for symptoms control, QoL improvement and resources optimization. Resumen: Antecedentes: La urticaria crónica (UC) es una enfermedad debilitante cuyo tratamiento es principalmente sintomático. El estudio UCREX tuvo como objetivo identificar el perfil de los pacientes con UC, el manejo de la enfermedad y la calidad de vida (CdV) en la práctica clínica diaria en España. Métodos: Estudio observacional, prospectivo, multicéntrico de 12 meses, que incluyó pacientes con UC de novo o establecida que acudieron a la consulta de dermatología/alergología de 39 hospitales españoles. Las variables principales fueron: el Urticaria Activity Score (UAS) y el UAS por siete días (UAS7). Las variables secundarias fueron: el cuestionario de CdV de urticaria crónica (CU-Q2oL), el EuroQol-5 Dimensiones (EQ-5D), la escala Medical Outcomes Study Sleep (MOS-Sleep) y la escala hospitalaria de ansiedad y depresión (HADS). Resultados: Se incluyeron 361 pacientes, de los cuales 176 (48,8%) formaron parte del análisis del objetivo principal. La edad media (DE) fue de 46,6 (14,2) años y el 71,8% eran del sexo femenino. El año anterior al periodo de inclusión de los pacientes, la mayoría de ellos (57,1%) se habían tratado con antihistamínicos H1 no sedantes (AHNS-H1). En la basal, se registró una media (DE) de 3,6 (6,8) de visitas a atención primaria. La media (DE) del UAS7 en la basal fue de 14,3 (11,0) y del CU-Q2oL 24,1 (17,0), observándose una tendencia en la mejoría en 8,6 (9,7) y 13,9 (15,0), respectivamente, a los 12 meses. El MOS-Sleep y el EQ-5D se mantuvieron estables durante el estudio, excepto por el dolor/malestar y la ansiedad/depresión que pasaron de 58,7 y 49,6% a 29,6 y 26,9%, respectivamente. En situación basal, el HADS mostró una ansiedad media (DE) de 8,7 (4,5) y una depresión de 5,1 (4,4), disminuyendo respectivamente a 7,0 (4,3) y 4,7 (4,3) a los 12 meses. Conclusiones: Aunque la mayoría de los pacientes son tratados con AHNS-H1, la actividad de la enfermedad sigue siendo importante, afectando negativamente a su CdV, su actividad laboral y repercutiendo negativamente en el uso de recursos sanitarios. Un manejo adecuado de la enfermedad podría ser la base para alcanzar el control de los síntomas, la mejora de la CdV y la optimización de los recursos sanitarios necesarios.

Introducción: los tatuajes permanentes han tenido un gran auge durante las tres últimas décadas, por lo tanto, las complicaciones dermatológicas asociadas a este procedimiento también se han incrementado, y cada vez son más frecuentes en los servicios de urgencias y consulta externa, donde son abordados por el médico de atención primaria. Métodos: se realizó una búsqueda ampliada de la literatura en inglés, español y francés en las bases de datos PubMed, Medscape, Embase, LILACS, Ovid y Google Scholar. También se llevó a cabo una búsqueda manual de las referencias de los artículos seleccionados. Se utilizaron palabras claves como tatuajes permanentes, complicaciones cutáneas, tintas, leyes, entre otros. La literatura fue seleccionada teniendo en cuenta su calidad metodológica y científica; se excluyeron los artículos que trataban de tatuajes de henna y temporales. Resultados: se evidenció un vacío en la literatura, que no sólo limita el acceso al conocimiento sobre el tema, sino que dificulta el diagnóstico y tratamiento oportuno de las complicaciones de los tatuajes, por parte del médico general. Conclusión: los tatuajes alteran la barrera física e inmunológica que proporciona la piel. Reconocer las manifestaciones clínicas de sus complicaciones aporta elementos valiosos para su prevención, diagnóstico y tratamiento.