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2. First-in-Man Noninvasive Initial Diagnostic Approach of Primary CNS Lymphoma Versus Glioblastoma Using PET With 18F-Fludarabine and l-[methyl-11C]Methionine

Author

Postnov, Andrey, primary, Toutain, Jérôme, additional, Pronin, Igor, additional, Valable, Samuel, additional, Gourand, Fabienne, additional, Kalaeva, Diana, additional, Vikhrova, Nina, additional, Pyzhik, Elena, additional, Guillouet, Stéphane, additional, Kobyakov, Grigoriy, additional, Khokholova, Ekaterina, additional, Pitskhelauri, David, additional, Usachev, Dmitry, additional, Maryashev, Sergey, additional, Rizhova, Marina, additional, Potapov, Alexander, additional, and Derlon, Jean-Michel, additional

Published
2022
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3. Simultaneous mapping of vasculature, hypoxia and proliferation using DSC-MRI, 18F-FMISO PET, and 18F-FLT PET in relation to contrast enhancement in newly diagnosed glioblastoma

Author

Collet, Solène, Guillamo, Jean Sébastien, Berro, David Hassanein, Chakhoyan, Ararat, Constans, Jean-Marc, Lechapt-Zalcman, Emmanuèle, Derlon, Jean-Michel, Hatt, Mathieu, Visvikis, Dimitris, Guillouet, Stéphane, Perrio, Cécile, Bernaudin, Myriam, Samuel, Valable, Hypoxie, physiopathologies cérébrovasculaire et tumorale (CERVOxy), Imagerie et Stratégies Thérapeutiques des pathologies Cérébrales et Tumorales (ISTCT), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Service de Neurochirurgie [CHU Caen], Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), Department of Neurology [UCLA], University of California [Los Angeles] (UCLA), University of California (UC)-University of California (UC)-David Geffen School of Medicine [Los Angeles], University of California (UC)-University of California (UC), CHU Amiens-Picardie, Laboratoire d'Anatomie Pathologique [CHU Caen], Laboratoire de Traitement de l'Information Medicale (LaTIM), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), Laboratoire de Développements Méthodologiques en Tomographie par Emission de Positons (LDM-TEP), Service Hospitalier Frédéric Joliot (SHFJ), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Imagerie et Stratégies Thérapeutiques des pathologies Cérébrales et Tumorales (ISTCT), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS), Couteau, Florence, UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Université de Caen Normandie (UNICAEN), Normandie Université (NU), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), University of California-University of California-David Geffen School of Medicine [Los Angeles], University of California-University of California, Institut National de la Santé et de la Recherche Médicale (INSERM)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)-Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Imagerie et Stratégies Thérapeutiques des pathologies Cérébrales et Tumorales (ISTCT)

Subjects
[SDV] Life Sciences [q-bio], Glioblastoma, PET, Vascular, [SDV]Life Sciences [q-bio], Proliferation, [CHIM] Chemical Sciences, Vasculature, [CHIM]Chemical Sciences, Oncology: Brain, Hypoxia, MRI
Abstract

CERVOXY/LDM TEP COLL; International audience; Conventional MRI plays a key role in the management of patients with high grade glioma but multiparametric MRI and PET tracers could provide further information to better characterize the tumor metabolism and heterogeneity, by identifying the regions having a high risk of recurrence. In this study, we focused on the proliferation, hypervascularization and hypoxia, all factors considered as factors of poor prognosis. They were assessed by measuring the uptake of 18F-FLT, the rCBV maps and the uptake of 18F-FMISO, respectively. For each modality, the volumes and high uptake sub-volumes (hotspots) were semi-automatically segmented and compared to contrast enhancement (CE) volume on T1w-Gd images, commonly used in the management of patient with glioblastoma. Methods: DSC MRI (31 patients), 18F-FLT PET (20 patients) and/or 18F-FMISO PET (20 patients), for a total of 31 patients, were performed on pre-operative glioblastoma patients. Volumes and hotspots were segmented on SUV maps for 18F-FLT (using FLAB) and 18F-FMISO (using mean contralateral + 3.3 SD) PET and on rCBV maps (using mean contralateral + 1.96 SD) for DSC MRI and overlaid on T1w-Gd images. For each modality, the percentage of peripheral volumes and the peripheral hotspot outside the CE volume were calculated. Results: All tumors showed high proliferation, hypervascularization and hypoxic regions. Images also showed pronounced heterogeneity of both tracers uptake and rCBV maps, within each individual case. Overlaid volumes on T1w-Gd images showed that some proliferative, hypervascularization and hypoxic regions extended beyond the CE volume but with marked differences between patients. The ranges of peripheral volume outside the CE volume were [1.6% - 155.5 %], [1.5% - 89.5%] and [3.1% - 78.0%] for 18F-FLT, rCBV and 18F-FMISO respectively. All patients had hyperproliferative hotspots outside CE volume, whereas hotspots of hypervasculature and hypoxia were mainly detected within the enhancing region. Conclusion: The spatial analysis of the multiparametric maps with the segmented volumes and hotspots provides valuable information to optimize the management and treatment of the patients with glioblastoma.

Published
2021
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6. Cartographie simultanée de la vascularisation, de l’hypoxie et de la prolifération à l’aide de l’IRM de perfusion, la tep au 18f-fmiso et au 18f-flt, en relation avec la prise de contraste dans les glioblastomes

Author

Berro, David Hassanein, primary, Collet, Solène, additional, Guillamo, Jean-Sébastien, additional, Chakhoyan, Ararat, additional, Constans, Jean-Marc, additional, Lechapt-Zalcman, Emmanuèle, additional, Derlon, Jean-Michel, additional, Hatt, Mathieu, additional, Visvikis, Dimitris, additional, Guillouet, Stéphane, additional, Perrio, Cécile, additional, Bernaudin, Myriam, additional, and Valable, Samuel, additional

Published
2021
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7. Simultaneous Mapping of Vasculature, Hypoxia, and Proliferation Using Dynamic Susceptibility Contrast MRI, 18F-FMISO PET, and 18F-FLT PET in Relation to Contrast Enhancement in Newly Diagnosed Glioblastoma

Author

Collet, Solène, primary, Guillamo, Jean-Sébastien, additional, Berro, David Hassanein, additional, Chakhoyan, Ararat, additional, Constans, Jean-Marc, additional, Lechapt-Zalcman, Emmanuèle, additional, Derlon, Jean-Michel, additional, Hatt, Mathieu, additional, Visvikis, Dimitris, additional, Guillouet, Stéphane, additional, Perrio, Cécile, additional, Bernaudin, Myriam, additional, and Valable, Samuel, additional

Published
2021
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8. First-in-Man Noninvasive Initial Diagnostic Approach of Primary CNS Lymphoma Versus Glioblastoma Using PET With 18 F-Fludarabine and l-[methyl- 11 C]Methionine.

Author

Postnov, Andrey, Toutain, Jérôme, Pronin, Igor, Valable, Samuel, Gourand, Fabienne, Kalaeva, Diana, Vikhrova, Nina, Pyzhik, Elena, Guillouet, Stéphane, Kobyakov, Grigoriy, Khokholova, Ekaterina, Pitskhelauri, David, Usachev, Dmitry, Maryashev, Sergey, Rizhova, Marina, Potapov, Alexander, and Derlon, Jean-Michel

Published
2022
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14. Simultaneous mapping of vasculature, hypoxia and proliferation using DSC-MRI, 18F-FMISO PET, and 18F-FLT PET in relation to contrast enhancement in newly diagnosed glioblastoma.

Author

Collet, Solène, Guillamo, Jean-Sébastien, Berro, David Hassanein, Chakhoyan, Ararat, Constans, Jean-marc, Lechapt-Zalcman, Emmanuèle, Derlon, Jean-Michel, Hatt, Mathieu, Visvikis, Dimitris, Guillouet, Stéphane, Perrio, Cécile, Bernaudin, Myriam, and Valable, Samuel

Published
2021
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31. Early spontaneous hyperperfusion after stroke

Author

Marchal, Gilles, primary, Furlan, Mauro, additional, Beaudouin, Vincent, additional, Rioux, Patrice, additional, Hauttement, Jean Louis, additional, Serrati, Carlo, additional, de la Sayette, Vincent, additional, Doze, François Le, additional, Viader, Fausto, additional, Derlon, Jean Michel, additional, and Baron, Jean Claude, additional

Published
1996
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34. Regional Cerebral Oxygen Consumption, Blood Flow, and Blood Volume in Healthy Human Aging

Author

Marchal, Gilles, Rioux, Patrice, Petit-Taboué, Marie-Christine, Sette, Giuliano, Travère, Jean-Marcel, Le Poec, Claude, Courtheoux, Patrick, Derlon, Jean-Michel, and Baron, Jean-Claude

Abstract

• Using high-resolution positron emission tomography and the oxygen 15 continuous inhalation method, we examined the changes in cerebral metabolic rate of oxygen, blood flow, blood volume, and oxygen extraction fraction as a function of age in 25 optimally healthy, unmedicated volunteers who ranged in age from 20 to 68 years. Subjects were strictly selected for absence of cerebrovascular risk factors, dementia, or mental disorders; they had neither biological nor clinical abnormalities, and no focal anomaly on computed tomographic scan. Regions of interest were determined according to the anatomical structures defined on corresponding computed tomographic scan cuts obtained using a stereotaxic head-positioning method. This same method was also used for positron emission tomographic imaging. There was no significant effect of aging on Paco2 values, hematocrit, arterial blood pressure, cholesterol and triglyceride levels, and blood glucose levels. In most cerebral cortex gyri, the cerebral metabolic rate of oxygen significantly decreased with age according to a linear pattern, with the same magnitude (about -6% per decade) in all four lobes and on both sides. This effect of age on cortical cerebral metabolic rate of oxygen persisted when the possible influence of cortical atrophy, gender, and head size were partialled out. In contrast, the white matter, deep gray nuclei, thalamus, and cerebellum were not significantly affected. The cerebral blood volume declined with a similar pattern to cerebral metabolic rate of oxygen, while changes in cerebral blood flow were less significant, presumably because of larger variance of data across subjects. Aging left the cerebral blood flow—cerebral blood volume—cerebral metabolic rate of oxygen coupling unaltered, as shown by lack of changes in both the oxygen extraction fraction and the cerebral blood flow—cerebral blood volume ratio. The selective decrease of oxygen metabolism in neocortex during normal aging could result from the combined effects of direct neuronal loss, cellular biological impairment, and functional deafferentation, and could underlie or reflect age-related cognitive changes.

Published
1992
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36. [11C]l-Methionine Uptake in Gliomas

Author

Derlon, Jean-Michel, primary, Bourdet, Catherine, additional, Bustany, Pierre, additional, Chatel, Marcel, additional, Theron, Jacques, additional, Darcel, Francoise, additional, and Syrota, Andre, additional

Published
1989
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37. Simultaneous Mapping of Vasculature, Hypoxia, and Proliferation Using Dynamic Susceptibility Contrast MRI, 18 F-FMISO PET, and 18 F-FLT PET in Relation to Contrast Enhancement in Newly Diagnosed Glioblastoma.

Author

Collet S, Guillamo JS, Berro DH, Chakhoyan A, Constans JM, Lechapt-Zalcman E, Derlon JM, Hatt M, Visvikis D, Guillouet S, Perrio C, Bernaudin M, and Valable S

Subjects
Humans, Female, Middle Aged, Male, Aged, Adult, Cell Proliferation, Neovascularization, Pathologic diagnostic imaging, Radiopharmaceuticals, Glioblastoma diagnostic imaging, Glioblastoma blood supply, Misonidazole analogs & derivatives, Positron-Emission Tomography methods, Dideoxynucleosides, Magnetic Resonance Imaging, Contrast Media, Brain Neoplasms diagnostic imaging
Abstract

Conventional MRI plays a key role in the management of patients with high-grade glioma, but multiparametric MRI and PET tracers could provide further information to better characterize tumor metabolism and heterogeneity by identifying regions having a high risk of recurrence. In this study, we focused on proliferation, hypervascularization, and hypoxia, all factors considered indicative of poor prognosis. They were assessed by measuring uptake of 18 F-3'-deoxy-3'- 18 F-fluorothymidine ( 18 F-FLT), relative cerebral blood volume (rCBV) maps, and uptake of 18 F-fluoromisonidazole ( 18 F-FMISO), respectively. For each modality, the volumes and high-uptake subvolumes (hot spots) were semiautomatically segmented and compared with the contrast enhancement (CE) volume on T1-weighted gadolinium-enhanced (T1w-Gd) images, commonly used in the management of patients with glioblastoma. Methods: Dynamic susceptibility contrast-enhanced MRI (31 patients), 18 F-FLT PET (20 patients), or 18 F-FMISO PET (20 patients), for a total of 31 patients, was performed on preoperative glioblastoma patients. Volumes and hot spots were segmented on SUV maps for 18 F-FLT PET (using the fuzzy locally adaptive bayesian algorithm) and 18 F-FMISO PET (using a mean contralateral image + 3.3 SDs) and on rCBV maps (using a mean contralateral image + 1.96 SDs) for dynamic susceptibility contrast-enhanced MRI and overlaid on T1w-Gd images. For each modality, the percentages of the peripheral volumes and the peripheral hot spots outside the CE volume were calculated. Results: All tumors showed highly proliferated, hypervascularized, and hypoxic regions. The images also showed pronounced heterogeneity of both tracers regarding their uptake and rCBV maps, within each individual patient. Overlaid volumes on T1w-Gd images showed that some proliferative, hypervascularized, and hypoxic regions extended beyond the CE volume but with marked differences between patients. The ranges of peripheral volume outside the CE volume were 1.6%-155.5%, 1.5%-89.5%, and 3.1%-78.0% for 18 F-FLT, rCBV, and 18 F-FMISO, respectively. All patients had hyperproliferative hot spots outside the CE volume, whereas hypervascularized and hypoxic hot spots were detected mainly within the enhancing region. Conclusion: Spatial analysis of multiparametric maps with segmented volumes and hot spots provides valuable information to optimize the management and treatment of patients with glioblastoma., (© 2021 by the Society of Nuclear Medicine and Molecular Imaging.)

Published
2021
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