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592 results on '"Derkach, Andriy"'

1. DNA liquid biopsy-based prediction of cancer-associated venous thromboembolism

Author

Jee, Justin, Brannon, A. Rose, Singh, Rohan, Derkach, Andriy, Fong, Christopher, Lee, Adrian, Gray, Lauren, Pichotta, Karl, Luthra, Anisha, Diosdado, Monica, Haque, Mohammad, Guo, Jiannan, Hernandez, Jennifer, Garg, Kavita, Wilhelm, Clare, Arcila, Maria E., Pavlakis, Nick, Clarke, Stephen, Shah, Sohrab P., Razavi, Pedram, Reis-Filho, Jorge S., Ladanyi, Marc, Schultz, Nikolaus, Zwicker, Jeffrey, Berger, Michael F., Li, Bob T., and Mantha, Simon

Published
2024
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2. Prevalence and impact of diabetes on survival of patients with multiple myeloma in different racial groups.

Author

Shah, Urvi, Moshier, Erin, Derkach, Andriy, Huang, Yuanhui, Mailankody, Sham, Tan, Carlyn, Maclachlan, Kylee, Hultcrantz, Malin, Korde, Neha, Hassoun, Hani, Thibaud, Santiago, Sanchez, Larysa, Rodriguez, Cesar, Richard, Shambavi, Richter, Joshua, Rossi, Adriana, Cho, Hearn, Lesokhin, Alexander, Usmani, Saad, Jagannath, Sundar, Parekh, Samir, Gallagher, Emily, and Chari, Ajai

Subjects
Animals, Humans, Mice, Diabetes Mellitus, Homeodomain Proteins, Multiple Myeloma, Prevalence, Racial Groups, Retrospective Studies, White People, Black People, Survival Rate
Abstract

Multiple myeloma (MM) is twice as common in Black individuals compared with in White individuals, and diabetes mellitus (DM) disproportionately affects Black patients. Although numerous studies have shown a correlation between DM and MM, this has not been studied in the context of race and in vivo mechanisms. We conducted a retrospective clinical study of 5383 patients with MM of which 15% had DM (White, 12% and Black, 25%). Multivariable Cox models showed reduced overall survival (OS) for patients with DM (hazard ratio, 1.27; 95% confidence interval, 1.11-1.47; P < .001). This appeared to be driven by a marked difference in OS between White patients with and without DM but not in Black patients. In contrast, obesity was associated with better OS in Black patients but not in White patients. To complement this analysis, we assessed MM growth in a genetically engineered immunocompromised nonobese diabetic (Rag1-/-/muscle creatinine kinase promoter expression of a human IGF1R [M] with a lysine [K] to arginine [R] point mutation) mouse model to evaluate the mechanisms linking DM and MM. MM.1S xenografts grew in more Rag1-/-/MKR mice and grew more rapidly in the Rag1-/-/MKR mice compared with in controls. Western blot analysis found that MM1.S xenografts from Rag1-/-/MKR mice had higher phosphorylated S6 ribosomal protein (Ser235/236) levels, indicating greater activation of the mammalian target of rapamycin pathway. Our study is, to our knowledge, the first to evaluate racial differences in DM prevalence and survival in MM, as well as the effect of DM on tumor growth in mouse models. Our results suggest that DM may contribute to the higher incidence of MM in Black patients; and to improve survival in MM, DM management cannot be ignored.

Published
2024

3. Colesevelam for lenalidomide associated diarrhea in patients with multiple myeloma

Author

Hultcrantz, Malin, Hassoun, Hani, Korde, Neha, MacLachlan, Kylee, Mailankody, Sham, Patel, Dhwani, Shah, Urvi A., Tan, Carlyn Rose, Chung, David J., Lahoud, Oscar B., Landau, Heather J., Scordo, Michael, Shah, Gunjan L., Giralt, Sergio A., Pianko, Matthew J., Burge, Miranda, Barnett, Kelly, Salcedo, Meghan, Caple, Julia, Tran, Linh, Blaslov, Jenna, Shekarkhand, Tala, Hamid, Selena, Nemirovsky, David, Derkach, Andriy, Arisa, Oluwatobi, Peer, Cody J., Figg, William D., Usmani, Saad Z., Landgren, Ola, and Lesokhin, Alexander M.

Published
2024
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4. Comparison of infectious complications with BCMA-directed therapies in multiple myeloma

Author

Nath, Karthik, Shekarkhand, Tala, Nemirovsky, David, Derkach, Andriy, Costa, Bruno Almeida, Nishimura, Noriko, Farzana, Tasmin, Rueda, Colin, Chung, David J., Landau, Heather J., Lahoud, Oscar B., Scordo, Michael, Shah, Gunjan L., Hassoun, Hani, Maclachlan, Kylee, Korde, Neha, Shah, Urvi A., Tan, Carlyn Rose, Hultcrantz, Malin, Giralt, Sergio A., Usmani, Saad Z., Shahid, Zainab, Mailankody, Sham, and Lesokhin, Alexander M.

Published
2024
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8. Sustained Minimal Residual Disease Negativity in Multiple Myeloma is Associated with Stool Butyrate and Healthier Plant-Based Diets.

Author

Shah, Urvi A, Maclachlan, Kylee H, Derkach, Andriy, Salcedo, Meghan, Barnett, Kelly, Caple, Julia, Blaslov, Jenna, Tran, Linh, Ciardiello, Amanda, Burge, Miranda, Shekarkhand, Tala, Adintori, Peter, Cross, Justin, Pianko, Matthew J, Hosszu, Kinga, McAvoy, Devin, Mailankody, Sham, Korde, Neha, Hultcrantz, Malin, Hassoun, Hani, Tan, Carlyn R, Lu, Sydney X, Patel, Dhwani, Diamond, Benjamin, Shah, Gunjan, Scordo, Michael, Lahoud, Oscar, Chung, David J, Landau, Heather, Usmani, Saad Z, Giralt, Sergio, Taur, Ying, Landgren, C Ola, Block, Gladys, Block, Torin, Peled, Jonathan U, van den Brink, Marcel RM, and Lesokhin, Alexander M

Subjects
Nutrition, Rare Diseases, Complementary and Integrative Health, Clinical Research, Cancer, Hematology, Oral and gastrointestinal, Good Health and Well Being, Humans, Multiple Myeloma, Butyrates, Neoplasm, Residual, Diet, Healthy, Diet, Vegetarian, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

PurposeSustained minimal residual disease (MRD) negativity is associated with long-term survival in multiple myeloma. The gut microbiome is affected by diet, and in turn can modulate host immunity, for example through production of short-chain fatty acids including butyrate. We hypothesized that dietary factors affect the microbiome (abundance of butyrate-producing bacteria or stool butyrate concentration) and may be associated with multiple myeloma outcomes.Experimental designWe examined the relationship of dietary factors (via a food frequency questionnaire), stool metabolites (via gas chromatography-mass spectrometry), and the stool microbiome (via 16S sequencing - α-diversity and relative abundance of butyrate-producing bacteria) with sustained MRD negativity (via flow cytometry at two timepoints 1 year apart) in myeloma patients on lenalidomide maintenance. The Healthy Eating Index 2015 score and flavonoid nutrient values were calculated from the food frequency questionnaire. The Wilcoxon rank sum test was used to evaluate associations with two-sided P < 0.05 considered significant.ResultsAt 3 months, higher stool butyrate concentration (P = 0.037), butyrate producers (P = 0.025), and α-diversity (P = 0.0035) were associated with sustained MRD negativity. Healthier dietary proteins, (from seafood and plants), correlated with butyrate at 3 months (P = 0.009) and sustained MRD negativity (P = 0.05). Consumption of dietary flavonoids, plant nutrients with antioxidant effects, correlated with stool butyrate concentration (anthocyanidins P = 0.01, flavones P = 0.01, and flavanols P = 0.02).ConclusionsThis is the first study to demonstrate an association between a plant-based dietary pattern, stool butyrate production, and sustained MRD negativity in multiple myeloma, providing rationale to evaluate a prospective dietary intervention.

Published
2022

12. Bortezomib, lenalidomide and dexamethasone (VRd) vs carfilzomib, lenalidomide and dexamethasone (KRd) as induction therapy in newly diagnosed multiple myeloma

Author

Tan, Carlyn Rose, Derkach, Andriy, Nemirovsky, David, Ciardiello, Amanda, Diamond, Benjamin, Hultcrantz, Malin, Hassoun, Hani, Mailankody, Sham, Shah, Urvi, Maclachlan, Kylee, Patel, Dhwani, Lahoud, Oscar B., Landau, Heather J., Chung, David J., Shah, Gunjan L., Scordo, Michael, Giralt, Sergio A., Lesokhin, Alexander, Usmani, Saad Z., Landgren, Ola, and Korde, Neha

Published
2023
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13. Interaction between myelodysplasia-related gene mutations and ontogeny in acute myeloid leukemia

Author

McCarter, Joseph G. W., Nemirovsky, David, Famulare, Christopher A., Farnoud, Noushin, Mohanty, Abhinita S., Stone-Molloy, Zoe S., Chervin, Jordan, Ball, Brian J., Epstein-Peterson, Zachary D., Arcila, Maria E., Stonestrom, Aaron J., Dunbar, Andrew, Cai, Sheng F., Glass, Jacob L., Geyer, Mark B., Rampal, Raajit K., Berman, Ellin, Abdel-Wahab, Omar I., Stein, Eytan M., Tallman, Martin S., Levine, Ross L., Goldberg, Aaron D., Papaemmanuil, Elli, Zhang, Yanming, Roshal, Mikhail, Derkach, Andriy, and Xiao, Wenbin

Published
2023
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15. Correction: COVID-19 Infections and Outcomes in Patients with Multiple Myeloma in New York City: A Cohort Study from Five Academic Centers.

Author

Hultcrantz, Malin, Richter, Joshua, Rosenbaum, Cara, Patel, Dhwani, Smith, Eric, Korde, Neha, Lu, Sydney, Mailankody, Sham, Shah, Urvi, Lesokhin, Alexander, Hassoun, Hani, Tan, Carlyn, Maura, Francesco, Derkach, Andriy, Diamond, Benjamin, Rossi, Adriana, Pearse, Roger, Madduri, Deepu, Chari, Ajai, Kaminetzky, David, Braunstein, Marc, Gordillo, Christian, Reshef, Ran, Taur, Ying, Davies, Faith, Jagannath, Sundar, Niesvizky, Ruben, Lentzsch, Suzanne, Morgan, Gareth, and Landgren, Ola

Abstract

[This corrects the article DOI: 10.1158/2643-3230.BCD-20-0102.].

Published
2020

16. COVID-19 Infections and Clinical Outcomes in Patients with Multiple Myeloma in New York City: A Cohort Study from Five Academic Centers.

Author

Hultcrantz, Malin, Richter, Joshua, Rosenbaum, Cara, Patel, Dhwani, Smith, Eric, Korde, Neha, Lu, Sydney, Mailankody, Sham, Shah, Urvi, Lesokhin, Alexander, Hassoun, Hani, Tan, Carlyn, Maura, Francesco, Derkach, Andriy, Diamond, Benjamin, Rossi, Adriana, Pearse, Roger, Madduri, Deepu, Chari, Ajai, Kaminetzky, David, Braunstein, Marc, Gordillo, Christian, Reshef, Ran, Taur, Ying, Davies, Faith, Jagannath, Sundar, Niesvizky, Ruben, Lentzsch, Suzanne, Morgan, Gareth, and Landgren, Ola

Abstract

UNLABELLED: Patients with multiple myeloma have a compromised immune system, due to both the disease and antimyeloma therapies, and may therefore be particularly susceptible to COVID-19. Here, we report outcomes and risk factors for serious disease in patients with multiple myeloma treated at five large academic centers in New York City in the spring of 2020, during which it was a global epicenter of the SARS-CoV-2 pandemic. Of 100 patients with multiple myeloma (male 58%; median age 68) diagnosed with COVID-19, 75 were admitted; of these, 13 patients (17%) were placed on invasive mechanical ventilation, and 22 patients (29%) expired. Of the 25 nonadmitted patients, 4 were asymptomatic. There was a higher risk of adverse outcome (intensive care unit admission, mechanical ventilation, or death) in Hispanics/Latinos (n = 21), OR = 4.7 (95% confidence interval, 1.3-16.7), and African American Blacks (n = 33), OR = 3.5 (1.1-11.5), as compared with White patients (n = 36). Patients who met the adverse combined endpoint had overall higher levels of inflammatory markers and cytokine activation. None of the other studied risk factors were significantly associated (P > 0.05) with adverse outcome: hypertension (n = 56), OR = 2.2 (0.9-5.4); diabetes (n = 18), OR = 0.9 (0.3-2.9); age >65 years (n = 63), OR = 1.8 (0.7-4.6); high-dose melphalan with autologous stem cell transplant

Published
2020

17. Association of Body Mass Index with Fecal Microbial Diversity and Metabolites in the Northern Finland Birth Cohort.

Author

Loftfield, Erikka, Herzig, Karl-Heinz, Caporaso, J Gregory, Derkach, Andriy, Wan, Yunhu, Byrd, Doratha A, Vogtmann, Emily, Männikkö, Minna, Karhunen, Ville, Knight, Rob, Gunter, Marc J, Järvelin, Marjo-Riitta, and Sinha, Rashmi

Subjects
Feces, Humans, Body Mass Index, Cohort Studies, Cross-Sectional Studies, Adult, Middle Aged, Finland, Female, Male, Metabolomics, Nutrition, Digestive Diseases, Clinical Research, Prevention, Obesity, Cancer, Life Below Water, Medical and Health Sciences, Epidemiology
Abstract

BackgroundObesity is an established risk factor for multiple cancer types. Lower microbial richness has been linked to obesity, but human studies are inconsistent, and associations of early-life body mass index (BMI) with the fecal microbiome and metabolome are unknown.MethodsWe characterized the fecal microbiome (n = 563) and metabolome (n = 340) in the Northern Finland Birth Cohort 1966 using 16S rRNA gene sequencing and untargeted metabolomics. We estimated associations of adult BMI and BMI history with microbial features and metabolites using linear regression and Spearman correlations (rs ) and computed correlations between bacterial sequence variants and metabolites overall and by BMI category.ResultsMicrobial richness, including the number of sequence variants (rs = -0.21, P < 0.0001), decreased with increasing adult BMI but was not independently associated with BMI history. Adult BMI was associated with 56 metabolites but no bacterial genera. Significant correlations were observed between microbes in 5 bacterial phyla, including 18 bacterial genera, and metabolites in 49 of the 62 metabolic pathways evaluated. The genera with the strongest correlations with relative metabolite levels (positively and negatively) were Blautia, Oscillospira, and Ruminococcus in the Firmicutes phylum, but associations varied by adult BMI category.ConclusionsBMI is strongly related to fecal metabolite levels, and numerous associations between fecal microbial features and metabolite levels underscore the dynamic role of the gut microbiota in metabolism.ImpactCharacterizing the associations between the fecal microbiome, the fecal metabolome, and BMI, both recent and early-life exposures, provides critical background information for future research on cancer prevention and etiology.

Published
2020

18. Waldenström macroglobulinemia whole genome reveals prolonged germinal center activity and late copy number aberrations

Author

Maclachlan, Kylee H., Bagratuni, Tina, Kastritis, Efstathios, Ziccheddu, Bachisio, Lu, Sydney, Yellapantula, Venkata, Famulare, Chris, Argyropoulos, Kimon, Derkach, Andriy, Papaemmanuil, Elli, Dogan, Ahmet, Lesokhin, Alexander, Usmani, Saad Z., Landgren, C. Ola, Palomba, Lia M., Maura, Francesco, and Dimopoulos, Meletios A.

Published
2023
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19. Association of patient activity bio-profiles with health-related quality of life in patients with newly diagnosed multiple myeloma: a prospective observational cohort study

Author

Korde, Neha, Tavitian, Elizabet, Mastey, Donna, Lengfellner, Joseph, Hevroni, Gil, Zarski, Andrew, Salcedo, Meghan, Mailankody, Sham, Hassoun, Hani, Smith, Eric L., Hultcrantz, Malin, Shah, Urvi, Tan, Carlyn, Diamond, Benjamin, Shah, Gunjan, Scordo, Michael, Lahoud, Oscar, Chung, David J., Landau, Heather, Giralt, Sergio, Derkach, Andriy, Atkinson, Thomas M., Sabbatini, Paul, König, Francesca, Usmani, Saad Z., Landgren, Ola, and Lesokhin, Alexander M.

Published
2023
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20. Colesevelam for Lenalidomide Associated Diarrhea in Patients with Multiple Myeloma

Author

Hultcrantz, Malin, primary, Hassoun, Hani, additional, Korde, Neha, additional, Maclachlan, Kylee, additional, Mailankody, Sham, additional, Patel, Dhwani, additional, Shah, Urvi, additional, Tan, Carlyn Rose, additional, Chung, David, additional, Landau, Heather, additional, Scordo, Michael, additional, Shah, Gunjan, additional, Giralt, Sergio, additional, Lahoud, Oscar, additional, Pianko, Matthew, additional, Burge, Mirande, additional, Barnett, Kelly, additional, Shekarkhand, Tala, additional, Caple, Julia, additional, Blaslov, Jenna, additional, Tran, Linh, additional, Salcedo, Meghan, additional, Hamid, Selena, additional, Nemirovsky, David, additional, Derkach, Andriy, additional, Arisa, Oluwatobi, additional, Peer, Cody, additional, Figg, William, additional, Usmani, Saad, additional, Landgren, Ola, additional, and Lesokhin, Alexander, additional

Published
2024
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21. Case-Case Genome-Wide Analyses Identify Subtype-Informative Variants that Confer Risk for Breast Cancer

Author

Sun, Xiaohui, primary, Verma, Shiv Prakash, additional, Jia, Guochong, additional, Wang, Xinjun, additional, Ping, Jie, additional, Guo, Xingyi, additional, Shu, Xiao-Ou, additional, Chen, Jianhong, additional, Derkach, Andriy, additional, Cai, Qiuyin, additional, Liang, Xiaolin, additional, Long, Jirong, additional, Offit, Kenneth, additional, Oh, Jung Hun, additional, Reiner, Anne S., additional, Watt, Gordon P., additional, Woods, Meghan, additional, Yang, Yaohua, additional, Ambrosone, Christine B., additional, Ambs, Stefan, additional, Chen, Yu, additional, Concannon, Patrick, additional, Garcia-Closas, Montserrat, additional, Gu, Jian, additional, Haiman, Christopher A., additional, Hu, Jennifer J., additional, Huo, Dezheng, additional, John, Esther M., additional, Knight, Julia A., additional, Li, Christopher I., additional, Lynch, Charles F., additional, Mellemkjaer, Lene, additional, Nathanson, Katherine L., additional, Nemesure, Barbara, additional, Olopade, Olufunmilayo I., additional, Olshan, Andrew F., additional, Pal, Tuya, additional, Palmer, Julie R., additional, Press, Michael F., additional, Sanderson, Maureen, additional, Sandler, Dale P., additional, Troester, Melissa A., additional, Zheng, Wei, additional, Bernstein, Jonine L., additional, Buas, Matthew F., additional, and Shu, Xiang, additional

Published
2024
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22. Supplement use habits and perceptions in patients with plasma cell disorders.

Author

Leyfman, Yan, primary, Schach, Eliana, additional, Derkach, Andriy, additional, Castro, Francesca, additional, Hurtado Martínez, Jorge Arturo, additional, Sahagun Sanchez Aldana, Ana M., additional, Flores Pérez, Patricia Alejandra, additional, Malik, Maria, additional, Ahlstrom, Jennifer M., additional, Hydren, Jay R, additional, Usmani, Saad Zafar, additional, Mao, Jun J., additional, Chimonas, Susan, additional, and Shah, Urvi A, additional

Published
2024
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24. Clinical outcomes of retreatment with daratumumab-based regimens in anti-CD38 refractory multiple myeloma.

Author

Tan, Carlyn Rose Co, primary, Rueda, Colin, additional, Shekarkhand, Tala, additional, Derkach, Andriy, additional, Korde, Neha, additional, Maclachlan, Kylee, additional, Hultcrantz, Malin, additional, Hassoun, Hani, additional, Mailankody, Sham, additional, Shah, Urvi A, additional, Rajeeve, Sridevi, additional, Lahoud, Oscar Boutros, additional, Shah, Gunjan L., additional, Scordo, Michael, additional, Chung, David J., additional, Landau, Heather Jolie, additional, Giralt, Sergio, additional, Usmani, Saad Zafar, additional, and Lesokhin, Alexander M., additional

Published
2024
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30. Subset Testing and Analysis of Multiple Phenotypes (STAMP)

Author

Derkach, Andriy and Pfeiffer, Ruth M.

Subjects
Statistics - Methodology
Abstract

Meta-analysis of multiple genome-wide association studies (GWAS) is effective for detecting single or multi marker associations with complex traits. We develop a flexible procedure ("STAMP") based on mixture models to perform region based meta-analysis of different phenotypes using data from different GWAS and identify subsets of associated phenotypes. Our model framework helps distinguish true associations from between-study heterogeneity. As a measure of association we compute for each phenotype the posterior probability that the genetic region under investigation is truly associated. Extensive simulations show that STAMP is more powerful than standard approaches for meta analyses when the proportion of truly associated outcomes is $\leq$ 50\%. For other settings, the power of STAMP is similar to that of existing methods. We illustrate our method on two examples, the association of a region on chromosome 9p21 with risk of fourteen cancers, and the associations of expression of quantitative traits loci (eQTLs) from two genetic regions with their cis-SNPs measured in seventeen tissue types using data from The Cancer Genome Atlas (TCGA).

Published
2017

31. HMA/VEN treatment modifications and associated outcomes in <italic>IDH</italic>-mutant AML.

Author

Chin, Kuo-Kai, Derkach, Andriy, Famulare, Christopher, Gupta, Gaurav K., Borge, P. Dayand, Geyer, Mark B., Goldberg, Aaron D., Haque, Tamanna, Park, Jae H., Roeker, Lindsey E., Tallman, Martin S., Stahl, Maximilian, and Stein, Eytan M.

Subjects
*ACUTE myeloid leukemia, *EMERGENCY room visits, *FEBRILE neutropenia, *INDUCTION chemotherapy, *OVERALL survival
Abstract

AbstractHypomethylating agents (HMA) and venetoclax (VEN) are commonly used in patients with IDH-mutated (IDHm) acute myeloid leukemia (AML) ineligible for induction chemotherapy. While prior studies demonstrated high response and survival rates with HMA/VEN in IDHm AML, the impact of treatment modifications in real-world settings is unclear. We retrospectively reviewed 89 IDHm AML patients treated with HMA/VEN from January 2018 to June 2023. CR/CRi rates were 76% in newly diagnosed (ND) and 55% in relapsed/refractory (R/R) patients, and median overall survival was 29.2 months (ND) and 17.1 months (R/R), respectively. Treatment modifications were common. Early VEN reductions were associated with lower response rates but not worse survival. Prolonged cycles were not associated with worse response rates or survival. Significant neutropenia and ED visits or unplanned hospitalizations were considerable before and after CR/CRi, though febrile neutropenia decreased afterward. HMA/VEN is efficacious, with treatment modifications not affecting survival, though long-term toxicities are notable. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Multilineage involvement in KMT2A‐rearranged B acute lymphoblastic leukaemia: cell‐of‐origin, biology, and clinical implications

Author

Aypar, Umut, primary, Dilip, Deepika, additional, Gadde, Ramya, additional, Londono, Dory M, additional, Liu, Ying, additional, Gao, Qi, additional, Geyer, Mark B, additional, Derkach, Andriy, additional, Zhang, Yanming, additional, Glass, Jacob L, additional, Roshal, Mikhail, additional, and Xiao, Wenbin, additional

Published
2024
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34. Somatic mutations in FAS pathway increase hemophagocytic lymphohistiocytosis risk in T- and/or NK-cell lymphoma patients

Author

Liu, Ying, primary, Sardana, Rohan, additional, Nemirovsky, David, additional, Frosina, Denise, additional, Jungbluth, Achim, additional, Johnson, William T, additional, Vardhana, Santosha A, additional, Arcila, Maria E., additional, Horwitz, Steven M, additional, Derkach, Andriy, additional, Dogan, Ahmet, additional, and Xiao, Wenbin, additional

Published
2024
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36. Dynamics of minimal residual disease in patients with multiple myeloma on continuous lenalidomide maintenance: a single-arm, single-centre, phase 2 trial

Author

Diamond, Benjamin, Korde, Neha, Lesokhin, Alexander M, Smith, Eric L, Shah, Urvi, Mailankody, Sham, Hultcrantz, Malin, Hassoun, Hani, Lu, Sydney X, Tan, Carlyn, Rustad, Even H, Maura, Francesco, Maclachlan, Kylee, Peterson, Tim, Derkach, Andriy, Devlin, Sean, Landau, Heather J, Scordo, Michael, Chung, David J, Shah, Gunjan L, Lahoud, Oscar, Thoren, Katie, Murata, Kazunori, Ramanathan, Lakshmi, Arcila, Maria E, Ho, Caleb, Roshal, Mikhail, Dogan, Ahmet, Giralt, Sergio A, and Landgren, Ola

Published
2021
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37. Plasmacytoid dendritic cell expansion defines a distinct subset of RUNX1-mutated acute myeloid leukemia

Author

Xiao, Wenbin, Chan, Alexander, Waarts, Michael R., Mishra, Tanmay, Liu, Ying, Cai, Sheng F., Yao, Jinjuan, Gao, Qi, Bowman, Robert L., Koche, Richard P., Csete, Isabelle S., DelGaudio, Nicole L., Derkach, Andriy, Baik, Jeeyeon, Yanis, Sophia, Famulare, Christopher A., Patel, Minal, Arcila, Maria E., Stahl, Maximilian, Rampal, Raajit K., Tallman, Martin S., Zhang, Yanming, Dogan, Ahmet, Goldberg, Aaron D., Roshal, Mikhail, and Levine, Ross L.

Published
2021
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38. Clinical and molecular predictors of response and survival following venetoclax therapy in relapsed/refractory AML

Author

Stahl, Maximilian, Menghrajani, Kamal, Derkach, Andriy, Chan, Alexander, Xiao, Wenbin, Glass, Jacob, King, Amber C., Daniyan, Anthony F., Famulare, Christopher, Cuello, Bernadette M., Horvat, Troy Z., Abdel-Wahab, Omar, Levine, Ross L., Viny, Aaron D., Stein, Eytan M., Cai, Sheng F., Roshal, Mikhail, Tallman, Martin S., and Goldberg, Aaron D.

Published
2021
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40. Nutrition perceptions, needs and practices among patients with plasma cell disorders

Author

Malik, Maria A., Sweeney, Nathan W., Jafri, Mohammad, Derkach, Andriy, Chmielewski, Cynthia, Adintori, Peter A., Mailankody, Sham, Korde, Neha, Tan, Carlyn R., Hassoun, Hani, Hultcrantz, Malin, Hillengass, Jens, McCann, Susan E., Iyengar, Neil, Usmani, Saad, Giralt, Sergio A., Landgren, Ola, van den Brink, Marcel R. M., Ahlstrom, Jennifer M., Lesokhin, Alexander M., D’Souza, Anita, Chimonas, Susan, and Shah, Urvi A.

Published
2022
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42. Comparison of Infectious Complications with BCMA-directed Therapies in Multiple Myeloma

Author

Lesokhin, Alexander, primary, Nath, Karthik, additional, Shekarkhand, Tala, additional, Nemirovsky, David, additional, Derkach, Andriy, additional, Costa, Bruno Almeida, additional, Nishimura, Noriko, additional, Farzana, Tasmin, additional, Rueda, Colin, additional, Chung, David, additional, Landau, Heather, additional, Lahoud, Oscar, additional, Scordo, Michael, additional, Shah, Gunjan, additional, Hassoun, Hani, additional, Maclachlan, Kylee, additional, Korde, Neha, additional, Shah, Urvi, additional, Tan, Carlyn Rose, additional, Hultcrantz, Malin, additional, Giralt, Sergio, additional, Usmani, Saad, additional, Shahid, Zainab, additional, and Mailankody, Sham, additional

Published
2024
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44. Genomic Classification and Individualized Prognosis in Multiple Myeloma

Author

Maura, Francesco, primary, Rajanna, Arjun Raj, additional, Ziccheddu, Bachisio, additional, Poos, Alexandra M., additional, Derkach, Andriy, additional, Maclachlan, Kylee, additional, Durante, Michael, additional, Diamond, Benjamin, additional, Papadimitriou, Marios, additional, Davies, Faith, additional, Boyle, Eileen M., additional, Walker, Brian, additional, Hultcrantz, Malin, additional, Silva, Ariosto, additional, Hampton, Oliver, additional, Teer, Jamie K., additional, Siegel, Erin M., additional, Bolli, Niccolò, additional, Jackson, Graham H., additional, Kaiser, Martin, additional, Pawlyn, Charlotte, additional, Cook, Gordon, additional, Kazandjian, Dickran, additional, Stein, Caleb, additional, Chesi, Marta, additional, Bergsagel, Leif, additional, Mai, Elias K., additional, Goldschmidt, Hartmut, additional, Weisel, Katja C., additional, Fenk, Roland, additional, Raab, Marc S., additional, Van Rhee, Fritz, additional, Usmani, Saad, additional, Shain, Kenneth H., additional, Weinhold, Niels, additional, Morgan, Gareth, additional, and Landgren, Ola, additional

Published
2024
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45. A High-Fiber Dietary Intervention (NUTRIVENTION) in Precursor Plasma Cell Disorders Improves Disease Biomarkers and Delays Progression to Myeloma

Author

Shah, Urvi, primary, Cogrossi, Laura Lucia, additional, Derkach, Andriy, additional, Castro, Francesca, additional, Fei, Teng, additional, DeWolf, Susan, additional, Garces, Juan-Jose, additional, Policastro, Anna, additional, Grioni, Matteo, additional, Sisti, Sofia, additional, Blaslov, Jenna, additional, Adintori, Peter, additional, Hosszu, Kinga K., additional, McAvoy, Devin, additional, Baichoo, Mirae, additional, Cross, Justin R., additional, Anuraj, Aishwarya, additional, Pohl, Charlotte, additional, Ramos, Ruben, additional, Paredes, Jenny, additional, Gipson, Brianna, additional, Maclachlan, Kylee, additional, Gradissimo, Ana, additional, Boiocchi, Leonardo, additional, Koche, Richard, additional, Chaligne, Ronan, additional, Block, Torin, additional, Korde, Neha, additional, Tan, Carlyn Rose, additional, Hultcrantz, Malin, additional, Hassoun, Hani, additional, Shah, Gunjan, additional, Scordo, Michael, additional, Lahoud, Oscar B., additional, Chung, David J., additional, Landau, Heather J., additional, Peled, Jonathan U., additional, Clementi, Nicola, additional, Chesi, Marta, additional, Bergsagel, Peter, additional, Mailankody, Sham, additional, Pollak, Michael, additional, D&apos;Souza, Anita, additional, Landgren, Ola, additional, Chimonas, Susan, additional, Giralt, Sergio A., additional, Usmani, Saad, additional, Iyengar, Neil M., additional, Lesokhin, Alexander, additional, Bellone, Matteo, additional, and van den Brink, Marcel R.M., additional

Published
2024
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47. Clonal hematopoiesis is associated with risk of severe Covid-19

Author

Bolton, Kelly L., Koh, Youngil, Foote, Michael B., Im, Hogune, Jee, Justin, Sun, Choong Hyun, Safonov, Anton, Ptashkin, Ryan, Moon, Joon Ho, Lee, Ji Yeon, Jung, Jongtak, Kang, Chang Kyung, Song, Kyoung-Ho, Choe, Pyoeng Gyun, Park, Wan Beom, Kim, Hong Bin, Oh, Myoung-don, Song, Han, Kim, Sugyeong, Patel, Minal, Derkach, Andriy, Gedvilaite, Erika, Tkachuk, Kaitlyn A., Wiley, Brian J., Chan, Ireaneus C., Braunstein, Lior Z., Gao, Teng, Papaemmanuil, Elli, Esther Babady, N., Pessin, Melissa S., Kamboj, Mini, Diaz, Jr, Luis A., Ladanyi, Marc, Rauh, Michael J., Natarajan, Pradeep, Machiela, Mitchell J., Awadalla, Philip, Joseph, Vijai, Offit, Kenneth, Norton, Larry, Berger, Michael F., Levine, Ross L., Kim, Eu Suk, Kim, Nam Joong, and Zehir, Ahmet

Published
2021
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48. Whole-genome sequencing reveals progressive versus stable myeloma precursor conditions as two distinct entities

Author

Oben, Bénedith, Froyen, Guy, Maclachlan, Kylee H., Leongamornlert, Daniel, Abascal, Federico, Zheng-Lin, Binbin, Yellapantula, Venkata, Derkach, Andriy, Geerdens, Ellen, Diamond, Benjamin T., Arijs, Ingrid, Maes, Brigitte, Vanhees, Kimberly, Hultcrantz, Malin, Manasanch, Elisabet E., Kazandjian, Dickran, Lesokhin, Alexander, Dogan, Ahmet, Zhang, Yanming, Mikulasova, Aneta, Walker, Brian, Morgan, Gareth, Campbell, Peter J., Landgren, Ola, Rummens, Jean-Luc, Bolli, Niccolò, and Maura, Francesco

Published
2021
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50. Pooled Association Tests for Rare Genetic Variants: A Review and Some New Results

Author

Derkach, Andriy, Lawless, Jerry F., and Sun, Lei

Subjects
Statistics - Methodology
Abstract

In the search for genetic factors that are associated with complex heritable human traits, considerable attention is now being focused on rare variants that individually have small effects. In response, numerous recent papers have proposed testing strategies to assess association between a group of rare variants and a trait, with competing claims about the performance of various tests. The power of a given test in fact depends on the nature of any association and on the rareness of the variants in question. We review such tests within a general framework that covers a wide range of genetic models and types of data. We study the performance of specific tests through exact or asymptotic power formulas and through novel simulation studies of over 10,000 different models. The tests considered are also applied to real sequence data from the 1000 Genomes project and provided by the GAW17. We recommend a testing strategy, but our results show that power to detect association in plausible genetic scenarios is low for studies of medium size unless a high proportion of the chosen variants are causal. Consequently, considerable attention must be given to relevant biological information that can guide the selection of variants for testing., Comment: Published in at http://dx.doi.org/10.1214/13-STS456 the Statistical Science (http://www.imstat.org/sts/) by the Institute of Mathematical Statistics (http://www.imstat.org)

Published
2012
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