224 results on '"Deri, Norma"'
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2. Incidence of SARS-CoV-2 infection in patients with multiple sclerosis who received SARS-CoV-2 vaccines and are under treatment with high-efficacy therapies in Argentina
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Carnero Contentti, Edgar, López, Pablo A., Pappolla, Agustín, Alonso, Ricardo, Silva, Berenice, Deri, Norma, Balbuena, María E., Burgos, Marcos, Luetic, Geraldine, Alvez Pinheiro, Amelia, Cabrera, Mariela, Hryb, Javier, Nofal, Pedro, Pestchanker, Claudia, Vrech, Carlos, Tavolini, Darío, Tkachuk, Verónica, Zanga, Gisela, Marrodan, Mariano, Ysrraelit, María Célica, Correale, Jorge, Carrá, Adriana, Federico, Belén, Garcea, Orlando, Fernandez Liguori, Nora, Patrucco, Liliana, Cristiano, Edgardo, Giunta, Diego, Alonso Serena, Marina, and Rojas, Juan I.
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- 2024
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3. Real-World Effectiveness and Safety of Cladribine in Multiple Sclerosis: Longitudinal Data From the Nationwide Registry in Argentina
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Rojas, Juan Ignacio, Alonso, Ricardo, Luetic, Geraldine, Patrucco, Liliana, Casas, Magdalena, Silva, Berenice, Miguez, Jimena, Deri, Norma, Vrech, Carlos, Liwacki, Susana, Piedrabuena, Raúl, Silva, Emanuel, Tkachuk, Verónica, Burgos, Marcos, Tavolini, Dario, Zanga, Gisela, Pinheiro, Amelia Alvez, Hryb, Javier, Leguizamon, Felisa, Knorre, Eduardo, Lopez, Pablo A., Martinez, Alejandra, Carrá, Adriana, Alonso Serena, Marina, Cristiano, Edgardo, Correale, Jorge, Garcea, Orlando, Fernandez Liguori, Nora, and Carnero Contentti, Edgar
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- 2024
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4. Treatment strategies and responses for attacks of neuromyelitis optica spectrum disorder: A real-world retrospective cohort study
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Carnero Contentti, Edgar, Lopez, Pablo A., Pettinicchi, Juan Pablo, Miguez, Jimena, Patrucco, Liliana, Cristiano, Edgardo, Liwacki, Susana, Tkachuk, Verónica, Balbuena, María E., Vrech, Carlos, Deri, Norma, Correale, Jorge, Marrodan, Mariano, Ysrraelit, María C., Leguizamon, Felisa, Luetic, Geraldine, Tavolini, Darío, Mainella, Carolina, Zanga, Gisela, Burgos, Marcos, Hryb, Javier, Barboza, Andrés, Lazaro, Luciana, Alonso, Ricardo, Fernández Liguori, Nora, Nadur, Débora, Alonso Serena, Marina, Caride, Alejandro, and Rojas, Juan I.
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- 2024
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5. Selection of disease modifying therapies in multiple sclerosis based on patient's age and disease activity: Data from a nationwide registry
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Piedrabuena, Maria A., Correale, Jorge, Fiol, Marcela, Marrodan, Mariano, Rojas, Juan I., Alonso, Marina, Pappolla, Agustín, Miguez, Jimena, Patrucco, Liliana, Cristiano, Edgardo, Vrech, Carlos, Cohen, Leila, Alonso, Ricardo, Silva, Berenice, Luetic, Geraldine, Deri, Norma, Burgos, Marcos, Liwacki, Susana, Piedrabuena, Raul, Tkachuk, Verónica, Barboza, Andres, Martinez, Alejandra, Balbuena, Maria E., Pinheiro, Amelia Alves, Nofal, Pedro, Lopez, Pablo A., Tavolini, Dario, Leguizamon, Felisa, Hryb, Javier P., Tizio, Santiago, Recchia, Luciano, Reich, Edgardo, Contentti, Edgar Carnero, Marcilla, Marcela Parada, Pagani, Fatima, Cabrera, Lorena M., Curbelo, Maria C., Mainella, Carolina, Liguori, Nora Fernández, Coppola, Mariano, Pettinicchi, Juan P., Carra, Adriana, Jose, Gustavo, Nadur, Debora, Bestoso, Santiago, Pestchanker, Claudia, Vazquez, Guido D., Martinez, Carlos M., and Ysrraelit, María C.
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- 2024
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6. Evaluation of the use of high-efficacy treatments (HETs) in patients with relapsing-remitting multiple sclerosis in Argentina
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Alonso, Ricardo, Casas, Magdalena, Lazaro, Luciana, Liguori, Nora Fernandez, Pita, Cecilia, Cohen, Leila, Rojas, Juan Ignacio, Pappolla, Agustín, Patrucco, Liliana, Cristiano, Edgardo, Burgos, Marcos, Vrech, Carlos, Piedrabuena, Raul, Pablo, Lopez, Deri, Norma, Luetic, Geraldine, Miguez, Jimena, Cabrera, Mariela, Martinez, Alejandra, Zanga, Gisela, Tkachuk, Verónica, Tizio, Santiago, Carnero Contentti, Edgar, Knorre, Eduardo, Leguizamon, Felisa, Mainella, Carolina, Nofal, Pedro, Liwacki, Susana, Hryb, Javier, Menichini, Maria, Pestchanker, Claudia, Garcea, Orlando, and Silva, Berenice
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- 2023
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7. Disability outcomes in NMOSD and MOGAD patients: data from a nationwide registry in Argentina
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Rojas, Juan I., Pappolla, Agustín, Patrucco, Liliana, Cristiano, Edgardo, Miguez, Jimena, Liwacki, Susana, Tkachuk, Verónica, Balbuena, María E., Vrech, Carlos, Deri, Norma, Correale, Jorge, Marrodan, Mariano, Ysrraelit, María C., Fiol, Marcela, Leguizamon, Felisa, Luetic, Geraldine, Menichini, María L., Lopez, Pablo A., Pettinicchi, Juan Pablo, Criniti, Juan, Caride, Alejandro, Tavolini, Darío, Mainella, Carolina, Zanga, Gisela, Burgos, Marcos, Hryb, Javier, Barboza, Andrés, Lazaro, Luciana, Alonso, Ricardo, Silva, Berenice, Fernández Liguori, Nora, Nadur, Débora, Chercoff, Aníbal, Martinez, Alejandra, Steinberg, Judith, Garcea, Orlando, Carrá, Adriana, Alonso Serena, Marina, and Carnero Contentti, Edgar
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- 2023
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8. Guía de práctica clínica: tratamiento agudo de las enfermedades inflamatorio-desmielinizantes del sistema nervioso central: esclerosis múltiple, espectro de la neuromielitis óptica, encefalomielitis diseminada aguda, enfermedades asociadas a anticuerpos antiglicoproteína de la membrana del oligodendrocito, mielitis aguda y neuritis óptica. Elaborada por el Grupo de Trabajo de Enfermedades Desmielinizantes. Sociedad Neurológica Argentina
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Hryb, Javier P., Tavolini, Darío, Pagani Cassará, Fátima, Silva, Berenice, Rojas, Juan Ignacio, Sinay, Vladimiro, Tkachuk, Verónica, Alonso, Ricardo, Carnero Contentti, Edgar, Ysrraelit, María Célica, Cohen, Leila, Rotta Escalante, Roberto, Mainella, Carolina, Martínez, Alejandra Diana, Liwacki, Susana, Luetic, Geraldine, Bestoso, Santiago, Vázquez, Guido, Piedrabuena, Raúl, Vrech, Carlos, Burgos, Marcos, Tizio, Santiago, Pappolla, Agustín, Alves Pinheiro, Amelia, Giachello, Susana, Bauer, Johana, Manin, Analisa, Deri, Norma, Pérez, Celia, Camerlingo, Sebastián, Cabrera, Lorena Mariela, López, Pablo A., Zanga, Gisela, Steinberg, Judith Diana, Miguez, Jimena, Jacobo, Miguel, Casas, Magdalena, Lazaro, Luciana Grimanesa, Isa, Santiago, Menichini, María Laura, Pita, Cecilia, Laffue, Alfredo, Vila, María Celia González, and Barboza, Andrés G.
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- 2023
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9. Incidence of COVID-19 after vaccination in people with multiple sclerosis in Argentina: Data from the nationwide registry RelevarEM
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Rojas, Juan I., Luetic, Geraldine G., Vrech, Carlos, Pappolla, Agustín, Patrucco, Liliana, Cristiano, Edgardo, Marrodan, Mariano, Ysrraelit, María C., Fiol, Marcela, Correale, Jorge, Cohen, Leila, Alonso, Ricardo, Silva, Berenice, Casas, Magdalena, Garcea, Orlando, Deri, Norma, Burgos, Marcos, Liwacki, Susana, Tkachuk, Verónica, Barboza, Andres, Piedrabuena, Raúl, Blaya, Patricio, Steinberg, Judith, Martínez, Alejandra, Carra, Adriana, Tavolini, Darío, López, Pablo, Knorre, Eduardo, Nofal, Pedro, Carnero Contentti, Edgar, Alves Pinheiro, Amelia, Leguizamon, Felisa, Silva, Emanuel, Hryb, Javier, Balbuena, María Eugenia, Zanga, Gisela, Kohler, Matías, Lazaro, Luciana, Tizio, Santiago, Mainella, Carolina, Blanche, Jorge, Parada Marcilla, Marcela, Fracaro, María Eugenia, Menichini, María Laura, Sgrilli, Gustavo, Divi, Pablo, Jacobo, Miguel, Cabrera, Mariela, Míguez, Jimena, Fernandez Liguori, Nora, Viglione, Juan Pablo, Nadur, Debora, Alonso Serena, Marina, and Nuñez, Sebastián
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- 2022
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10. Guía de práctica clínica: tratamiento sintomático de esclerosis múltiple. Grupo de Trabajo de Enfermedades Desmielinizantes. Sociedad Neurológica Argentina
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Barboza, Andrés G., Sinay, Vladimiro, Zanga, Gisela, Alonso, Ricardo, Silva, Berenice, Saladino, María Laura, Cohen, Leila, Luetic, Geraldine G., Camerlingo, Sebastián, Ysrraelit, María Célica, Tenembaun, Silvia N., Tarulla, Adriana, Carnero Contentti, Edgar, López, Pablo A., Pita, Cecilia, Tavolini, Darío, Steinberg, Judith, Menichini, María Laura, Rojas, Juan I., Tizio, Santiago, Tkachuk, Verónica, González, Fernando Adrián, Martínez, Alejandra, Laffue, Alfredo, Pagani Cassara, Fátima, Piedrabuena, Raúl, Pérez, Celia, Fernández Liguori, Nora, Eizaguirre, María Bárbara, Patrucco, Liliana, Deri, Norma Haydee, Hryb, Javier, and Mellinger, Surai
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- 2022
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11. Evaluation of the times of disability progression and related factors in patients with primary progressive multiple sclerosis from Argentina
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Alonso, Ricardo, Garcea, Orlando, Rojas, Juan Ignacio, Alonso, Marina, Lázaro, Luciana, López, Pablo, Casas, Magdalena, Tkachuk, Verónica, Steinberg, Judith, Barboza, Andrés, Martínez, Alejandra, Ysrraelit, Célica, Correale, Jorge, Marrodan, Mariano, Chertcoff, Aníbal, Deri, Norma, Miguez, Jimena, Patrucco, Liliana, Cristiano, Edgardo, Pestchanker, Claudia, Silva, Emanuel, Vrech, Carlos, Zanga, Gisela, Leguizamón, Felisa, Carnero Contentti, Edgar, Carra, Adriana, Mainella, Carolina, and Silva, Berenice Anabel
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- 2022
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12. Seasonal variation in attacks of neuromyelitis optica spectrum disorders and multiple sclerosis: Evaluation of 794 attacks from a nationwide registry in Argentina
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Carnero Contentti, Edgar, Lopez, Pablo A., Pettinicchi, Juan Pablo, Criniti, Juan, Pappolla, Agustín, Miguez, Jimena, Patrucco, Liliana, Cristiano, Edgardo, Liwacki, Susana, Tkachuk, Verónica, Balbuena, María E., Vrech, Carlos, Deri, Norma, Correale, Jorge, Marrodan, Mariano, Ysrraelit, María C., Leguizamon, Felisa, Luetic, Geraldine, Menichini, María L., Tavolini, Darío, Mainella, Carolina, Zanga, Gisela, Burgos, Marcos, Hryb, Javier, Barboza, Andrés, Lazaro, Luciana, Alonso, Ricardo, Fernández Liguori, Nora, Nadur, Débora, Chercoff, Aníbal, Alonso Serena, Marina, Caride, Alejandro, Paul, Friedemann, and Rojas, Juan I.
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- 2022
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13. Clinical and demographic characteristics of male MS patients included in the national registry-RelevarEM. Does sex or phenotype make the difference in the association with poor prognosis?
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Luetic, Geraldine G., Menichini, María Laura, Vrech, Carlos, Pappolla, Agustín, Patrucco, Liliana, Cristiano, Edgardo, Marrodán, Mariano, Ysrraelit, María C., Fiol, Marcela, Correale, Jorge, Cohen, Leila, Alonso, Ricardo, Silva, Berenice, Casas, Magdalena, Garcea, Orlando, Deri, Norma, Burgos, Marcos, Liwacki, Susana, Tkachuk, Verónica, Barboza, Andrés, Piedrabuena, Raúl, Blaya, Patricio, Steinberg, Judith, Martínez, Alejandra, Carrá, Adriana, Tavolini, Darío, López, Pablo, Knorre, Eduardo, Nofal, Pedro, Volman, Gabriel, Carnero Contentti, Edgar, Pinheiro, Amelia Alves, Leguizamon, Felisa, Silva, Emanuel, Hryb, Javier, Balbuena, María Eugenia, Zanga, Gisela, Kohler, Matías, Chertcoff, Aníbal, Lazaro, Luciana, Tizio, Santiago, Mainela, Carolina, Reich, Edgardo, Recchia, Luciano, Blanche, Jorge, Marcilla, Marcela Parada, Fracaro, María Eugenia, Sgrilli, Gustavo, Divi, Pablo, Jacobo, Miguel, Cabrera, Mariela, Pagani Cassara, Fátima, Sinay, Vladimiro, Curbelo, Celeste, Míguez, Jimena, Coppola, Mariano, Liguori, Nora Fernández, Martos, Iván, Pettinicchi, Juan Pablo, Viglione, Juan Pablo, José, Gustavo, Bestoso, Santiago, Manzi, Rubén, Vázquez, Guido, Nadur, Débora, Martínez, Carlos, Serena, Marina Alonso, and Rojas, Juan I.
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- 2022
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14. Routine CSF parameters as predictors of disease course in multiple sclerosis: an MSBase cohort study
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Dekeyser, Cathérine, primary, Hautekeete, Matthias, additional, Cambron, Melissa, additional, Van Pesch, Vincent, additional, Patti, Francesco, additional, Kuhle, Jens, additional, Khoury, Samia, additional, Lechner Scott, Jeanette, additional, Gerlach, Oliver, additional, Lugaresi, Alessandra, additional, Maimone, Davide, additional, Surcinelli, Andrea, additional, Grammond, Pierre, additional, Kalincik, Tomas, additional, Habek, Mario, additional, Willekens, Barbara, additional, Macdonell, Richard, additional, Lalive, Patrice, additional, Csepany, Tunde, additional, Butzkueven, Helmut, additional, Boz, Cavit, additional, Tomassini, Valentina, additional, Foschi, Matteo, additional, Sánchez-Menoyo, José Luis, additional, Altintas, Ayse, additional, Mrabet, Saloua, additional, Iuliano, Gerardo, additional, Sa, Maria Jose, additional, Alroughani, Raed, additional, Karabudak, Rana, additional, Aguera-Morales, Eduardo, additional, Gray, Orla, additional, de Gans, Koen, additional, van der Walt, Anneke, additional, McCombe, Pamela A, additional, Deri, Norma, additional, Garber, Justin, additional, Al-Asmi, Abdullah, additional, Skibina, Olga, additional, Duquette, Pierre, additional, Cartechini, Elisabetta, additional, Spitaleri, Daniele, additional, Gouider, Riadh, additional, Soysal, Aysun, additional, Van Hijfte, Liesbeth, additional, Slee, Mark, additional, Amato, Maria Pia, additional, Buzzard, Katherine, additional, and Laureys, Guy, additional
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- 2024
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15. Aggressive multiple sclerosis in Argentina: Data from the nationwide registry RelevarEM
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Kohler, Matías, Kohler, Eduardo, Vrech, Carlos, Pappolla, Agustín, Miguez, Jimena, Patrucco, Liliana, Correale, Jorge, Marrodan, Mariano, Gaitán, María I., Fiol, Marcela, Negrotto, Laura, Ysrraelit, María C., Cristiano, Edgardo, Carrá, Adriana, Steinberg, Judith, Martinez, Alejandra D., Curbelo, María C., Cohen, Leila, Alonso, Ricardo, Garcea, Orlando, Pita, Cecilia, Silva, Berenice, Luetic, Geraldine, Deri, Norma, Balbuena, Maria E., Tkachuk, Verónica, Carnero Contentti, Edgar, Lopez, Pablo A., Pettinicchi, Juan P., Caride, Alejandro, Burgos, Marcos, Leguizamon, Felisa, Knorre, Eduardo, Piedrabuena, Raúl, Barboza, Andrés, Liwacki, Susana, Nofal, Pedro, Volman, Gabriel, Alvez Pinheiro, Amelia, Hryb, Javier, Tavolini, Dario, Blaya, Patricio, Recchia, Luciano, Mainella, Carolina, Silva, Emanuel, Blanche, Jorge, Tizio, Santiago, Saladino, Maria L., Caceres, Fernando, Fernandez Liguori, Nora, Lazaro, Luciana, Zanga, Gisela, Parada Marcilla, Marcela, Fracaro, Maria E., Pagani Cassara, Fatima, Vazquez, Guido, Sinay, Vladimiro, Sgrilli, Gustavo, Divi, Pablo, Jacobo, Miguel, Reich, Edgardo, Cabrera, Lorena M., Menichini, María L., Coppola, Mariano, Martos, Ivan, Viglione, Juan P., Jose, Gustavo, Bestoso, Santiago, Manzi, Ruben, Giunta, Diego, Doldan, Maria.L., Alonso Serena, Marina, and Rojas, Juan I.
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- 2021
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16. COVID-19 in multiple sclerosis and neuromyelitis optica spectrum disorder patients in Latin America: COVID-19 in MS and NMOSD patients in LATAM
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Alonso, Ricardo, Silva, Berenice, Garcea, Orlando, Diaz, Patricio E. Correa, dos Passos, Giordani Rodrigues, Navarro, Deyanira A. Ramirez, Valle, Luis A. Garcia, Salinas, Luis C. Rodriguez, Negrotto, Laura, Luetic, Geraldine, Tkachuk, Verónica A., Míguez, Jimena, de Bedoya, Fernando Hamuy Diaz, Goiry, Lorna Galleguillos, Sánchez, Nicia E. Ramírez, Burgos, Marcos, Steinberg, Judith, Balbuena, Maria E., Alvarez, Priscilla Monterrey, López, Pablo A., Ysrraelit, María C., León, Rosalba A., Cohen, Aron Benzadon, Gracia, Fernando, Molina, Omaira, Casas, Magdalena, Deri, Norma H., Pappolla, Agustín, Patrucco, Liliana, Cristiano, Edgardo, Tavolini, Dario, Nadur, Debora, Granda, Ana M. Toral, Weiser, Roberto, Cassará, Fátima Pagani, Sinay, Vladimiro, Rodríguez, Claudia Cárcamo, Lazaro, Luciana G., Menichini, María L., Piedrabuena, Raúl, Escobar, Geraldine Orozco, Carrá, Adriana, Chertcoff, Anibal, Pujols, Biany Santos, Vrech, Carlos, Tarulla, Adriana, Carvajal, René, Mainella, Carolina, Becker, Jefferson, Peeters, Liesbet M., Walton, Clare, Serena, Marina Alonso, Nuñez, Sebastián, and Rojas, Juan I.
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- 2021
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17. What percentage of AQP4-ab-negative NMOSD patients are MOG-ab positive? A study from the Argentinean multiple sclerosis registry (RelevarEM)
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Carnero Contentti, Edgar, Lopez, Pablo A., Pettinicchi, Juan Pablo, Pappolla, Agustín, Miguez, Jimena, Patrucco, Liliana, Cristiano, Edgardo, Vrech, Carlos, Tkachuk, Verónica, Liwacki, Susana, Correale, Jorge, Marrodan, Mariano, Gaitán, María I., Fiol, Marcela, Negrotto, Laura, Ysrraelit, María C., Burgos, Marcos, Leguizamon, Felisa, Tavolini, Dario, Deri, Norma, Balbuena, Maria E., Mainella, Carolina, Luetic, Geraldine, Blaya, Patricio, Hryb, Javier, Menichini, María L., Alvez Pinheiro, Amelia, Nofal, Pedro, Zanga, Gisela, Barboza, Andrés, Martos, Ivan, Lazaro, Luciana, Alonso, Ricardo, Silva, Emanuel, Bestoso, Santiago, Fracaro, Maria E., Carrá, Adriana, Garcea, Orlando, Fernandez Liguori, Nora, Alonso Serena, Marina, Caride, Alejandro, and Rojas, Juan I.
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- 2021
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18. Usage trend of oral drugs for multiple sclerosis patients in Argentina
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Alonso, Ricardo, Garcea, Orlando, Eizaguirre, María Barbara, Man, Federico, Bizzo, Abril Lopez, Cohen, Leila, Rojas, Juan I, Patrucco, Liliana, Cristiano, Edgardo, Pita, Cecilia, Tkachuk, Veronica, Balbuena, Maria Eugenia, Carnero Contentti, Edgar, Lopez, Pablo, Pettinichi, Juan Pablo, Deri, Norma, Miguez, Jimena, Pappolla, Agustín, Lazaro, Luciana, Liguori, Nora Fernadez, Correale, Jorge, Carrá, Adriana, and Silva, Berenice A
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- 2021
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19. High birth weight and risk of multiple sclerosis: A multicentre study in Argentina
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Luetic, Geraldine G., Menichini, Maria L., Deri, Norma, Steinberg, Judith, Carrá, Adriana, Cristiano, Edgardo, Patrucco, Liliana, Curbelo, Maria C., and Rojas, Juan I.
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- 2021
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20. Guías de práctica para indicación y contraindicaciones de vacunación de pacientes con esclerosis múltiple
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Barboza, Andrés G., Sinay, Vladimiro, Silva, Berenice Anabel, Rojas, Juan I., Ysrraelit, María Célica, Carnero Contentti, Edgar, Negrotto, Laura, Tavolini, Darío, Deri, Norma, Tizio, Santiago, Gaitán, María Inés, Luetic, Geraldine, Patrucco, Liliana, Martínez, Alejandra D., Parada Marcilla, Marcela, Hryb, Javier, Alonso, Ricardo, Bestoso, Santiago, Cabrera, Lorena M., Cristiano, Edgardo, Jacobo, Miguel, Liwacki, Susana, Lopez, Pablo A., Mainella, Carolina, Menichini, María Laura, Miguez, Jimena, Pagani Cassara, Fatima, Pérez, Celia, Piedrabuena, Raúl, Rotta Escalante, Roberto, Steinberg, Judith, Tkachuk, Veronica Analia, Alejandro Vrech, Carlos, and Zanga, Gisela
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- 2021
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21. Do immunosuppressive treatments influence immune responses against adenovirusbased COVID-19 vaccines in patients with multiple sclerosis? An Argentine multicenter study.
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Silva, Berenice Anabel, Miglietta, Esteban, Casabona, Juan Cruz, Wenker, Shirley, Eizaguirre, María Bárbara, Alonso, Ricardo, Casas, Magdalena, Lázaro, Luciana Grimanesa, Man, Federico, Portuondo, Gustavo, Bisso, Abril Lopez, Zavala, Noelia, Casales, Federico, Imhoff, Gastón, Steinberg, Dra Judith, López, Pablo Adrián, Contentti, Edgar Carnero, Deri, Norma, Sinay, Vladimiro, and Hryb, Javier
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SARS-CoV-2 Omicron variant ,COVID-19 ,HUMORAL immunity ,DIMETHYL fumarate ,COVID-19 vaccines - Abstract
Introduction: There are no reports in LATAM related to longitudinal humoral and cellular response to adenovirus based COVID-19 vaccines in people with Multiple Sclerosis (pwMS) under different disease modifying therapies (DMTs) and neutralization of the Omicron and Wuhan variants of SARS-COV-2. Methods: IgG anti- SARS-COV-2 spike titer were measured in a cohort of 101 pwMS under fingolimod, dimethyl fumarate, cladribine and antiCD20, as well as 28 healthy controls (HC) were measured 6 weeks after vaccination with 2
nd dose (Sputnik V or AZD1222) and 3nd dose (homologous or heterologous schedule). Neutralizing capacity was against Omicron (BA.1) and Wuhan (D614G) variants and pseudotyped particles and Cellular response were analyzed.Results: Multivariate regression analysis showed anti-cd20 (β= -,349, 95% CI: -3655.6 - -369.01, p=0.017) and fingolimod (β=-,399, 95% CI: -3363.8 - -250.9, p=0.023) treatments as an independent factor associated with low antibody response (r² adjusted=0.157). After the 2nd dose we found a correlation between total and neutralizing titers against D614G (rho=0.6; p<0.001; slope 0.8, 95% CI:0.4-1.3), with no differences between DMTs. Neutralization capacity was lower for BA.1 (slope 0.3, 95%CI:0.1-0.4). After the 3rd dose, neutralization of BA.1 improved (slope: 0.9 95%CI:0.6-1.2), without differences between DMTs. A fraction of pwMS generated anti-Spike CD4+ and CD8+ T cell response. In contrast, pwMS under antiCD20 generated CD8+TNF+IL2+ response without differences with HC, even in the absence of humoral response. The 3rd dose significantly increased the neutralization against the Omicron, as observed in the immunocompetent population. Discussion: Findings regarding humoral and cellular response are consistent with previous reports [ABSTRACT FROM AUTHOR]- Published
- 2024
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22. Real-World Effectiveness and Safety of Cladribine in Multiple Sclerosis: Longitudinal Data From the Nationwide Registry in Argentina.
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Ignacio Rojas, Juan, Alonso, Ricardo, Luetic, Geraldine, Patrucco, Liliana, Casas, Magdalena, Silva, Berenice, Miguez, Jimena, Deri, Norma, Vrech, Carlos, Liwacki, Susana, Piedrabuena, Raúl, Silva, Emanuel, Tkachuk, Verónica, Burgos, Marcos, Tavolini, Dario, Zanga, Gisela, Pinheiro, Amelia Alvez, Hryb, Javier, Leguizamon, Felisa, and Knorre, Eduardo
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- 2024
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23. Consensus recommendations for family planning and pregnancy in multiple sclerosis in argentina
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Liguori, Nora Fernández, Alonso, Ricardo, Pinheiro, Amelia Alves, Balbuena, María E, Barboza, Andrés, Bestoso, Santiago, Burgos, Marcos, Cáceres, Fernando, Carnero Contentti, Edgar, Carrá, Adriana, Cristiano, Edgardo, Curbelo, María C, Deri, Norma, Fiol, Marcela, Gaitán, María I, Garcea, Orlando, Halfon, Mario, Hryb, Javier, Jacobo, Miguel, José, Gustavo, Knorre, Eduardo, López, Pablo, Luetic, Geraldine, Mainella, Carolina, Martínez, Alejandra, Miguez, Jimena, Nofal, Pedro, Pagani Cassará, Fátima, Marcilla, Marcela Parada, Piedrabuena, Raúl, Pita, Cecilia, Quarracino, Cecilia, Rojas, Juan I, Silva, Berenice, Sinay, Vladimiro, Steinberg, Judith, Tarulla, Adriana, Tavolini, Darío, Tkachuk, Verónica, Tizio, Santiago, Villa, Andrés, Vrech, Carlos, Ysrraelit, Célica, and Patrucco, Liliana
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- 2020
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24. Consensus recommendations on the management of multiple sclerosis patients in Argentina
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Cristiano, Edgardo, Rojas, Juan Ignacio, Alonso, Ricardo, Alvez Pinheiro, Amelia, Bacile, Elizabeth A., Balbuena, María Eugenia, Barboza, Andrés G., Bestoso, Santiago, Burgos, Marcos, Cáceres, Fernando, Carnero Contentti, Edgar, Curbelo, María Celeste, Deri, Norma, Fernandez Liguori, Nora, Gaitán, María Ines, Garcea, Orlando, Giunta, Diego, Halfon, Mario J., Hryb, Javier P., Jacobo, Miguel, Kohler, Eduardo, Luetic, Geraldine G., Maglio, Ignacio, Martínez, Alejandra D., Míguez, Jimena, Nofal, Pedro G., Patrucco, Liliana, Piedrabuena, Raúl, Rotta Escalante, Roberto, Saladino, María Laura, Silva, Berenice A., Sinay, Vladimiro, Tkachuk, Verónica, Villa, Andrés, Vrech, Carlos, Ysrraelit, María Célica, and Correale, Jorge
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- 2020
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25. Effectiveness and Safety of Early High-Efficacy Versus Escalation Therapy in Relapsing-Remitting Multiple Sclerosis in Argentina
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Rojas, Juan Ignacio, Patrucco, Liliana, Alonso, Ricardo, Garcea, Orlando, Deri, Norma, Carnero Contentti, Edgar, Lopez, Pablo A., Pettinicchi, Juan Pablo, Caride, Alejandro, and Cristiano, Edgardo
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- 2022
- Full Text
- View/download PDF
26. Clinical and demographic characteristics of primary progressive multiple sclerosis in Argentina: Argentinean registry cohort study (RelevarEM)
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Alonso, Ricardo, Quarracino, Cecilia, Eizaguirre, Bárbara, Cohen, Leila, Silva, Berenice, Pita, Cecilia, Rojas, Juan Ignacio, Pappolla, Agustín, Miguez, Jimena, Patrucco, Liliana, Cristiano, Edgardo, Vrech, Carlos, Volman, Gabriel, Silva, Emanuel, Barboza, Andres, Deri, Norma, Tkachuk, Verónica, Zanga, Gisela, Tavolini, Dario, Saladino, María Laura, Luetic, Geraldine, Menichini, María Laura, Carnero Contentti, Edgar, López, Pablo, Steinberg, Judith, Divi, Pablo, Hryb, Javier, Alves Pinheiro, Amelia, Carra, Adriana, Balbuena, María Eugenia, Lázaro, Luciana, Fernández Liguori, Nora, and Garcea, Orlando
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- 2020
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27. The Argentinean multiple sclerosis registry (RelevarEM): Methodological aspects and directions
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Rojas, Juan Ignacio, Carrá, Adriana, Correale, Jorge, Cristiano, Edgardo, Fernández Liguori, Nora, Alonso, Ricardo, Alvez Pinheiro, Amelia, Balbuena, María E., Barboza, Andrés G., Bestoso, Santiago, Blaya, Patricio A., Burgos, Marcos, Cabrera, Lorena M., Caride, Alejandro, Carnero Contentti, Edgar, Cohen, Leila, Curbelo, Celeste, Deri, Norma, Divi, Pablo, Fiol, Marcela, Fracaro, María E., Gaitán, María I., Hryb, Javier, Jacobo, Miguel, Knorre, Eduardo, Leguizamon, Felisa, Giunta, Diego, Alonso Serena, Marina, Doldan, María L., De Lio, Guillermo F., Liwacki, Susana del V., Lopez, Pablo A., Luetic, Geraldine, Mainella, Carolina, Manzi, Ruben, Marrodan, Mariano, Martinez, Alejandra D., Miguez, Jimena, Negrotto, Laura, Nofal, Pedro, Parada Marcilla, Marcela, Pettinicchi, Juan Pablo, Silva, Berenice A., Silva, Emanuel, Silveira, Facundo, Steinberg, Judith D., Tavolini, Dario, Tizio, Santiago, Tkachuk, Verónica, Vazquez, Guido, Volman, Gabriel, Vrech, Carlos, Ysrraelit, María C., Zanga, Gisela, Garcea, Orlando, and Patrucco, Liliana
- Published
- 2019
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28. Mortality of neuromyelitis optica spectrum disorder patients in an Argentinean population: A study from the RelevarEM registry
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Carnero Contentti, Edgar, primary, Lopez, Pablo A, additional, Pettinicchi, Juan Pablo, additional, Criniti, Juan, additional, Pappolla, Agustín, additional, Miguez, Jimena, additional, Cristiano, Edgardo, additional, Patrucco, Liliana, additional, Liwacki, Susana, additional, Tkachuk, Verónica, additional, Balbuena, María E, additional, Vrech, Carlos, additional, Deri, Norma, additional, Correale, Jorge, additional, Marrodan, Mariano, additional, Ysrraelit, María C, additional, Leguizamon, Felisa, additional, Luetic, Geraldine, additional, Menichini, María L, additional, Tavolini, Darío, additional, Mainella, Carolina, additional, Zanga, Gisela, additional, Burgos, Marcos, additional, Hryb, Javier, additional, Barboza, Andrés, additional, Lazaro, Luciana, additional, Alonso, Ricardo, additional, Fernández Liguori, Nora, additional, Nadur, Débora, additional, Alonso Serena, Marina, additional, Caride, Alejandro, additional, Paul, Friedemann, additional, and Rojas, Juan I, additional
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- 2023
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29. Natalizumab treatment shows low cumulative probabilities of confirmed disability worsening to EDSS milestones in the long-term setting
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Correale, Jorge, Caride, Alejandro, Deri, Norma H., Ballario, Carlos, Broadley, Simon, Kneebone, Chris, Barnett, Michael, Pollard, John, Hodgkinson, Suzanne, Kermode, Allan, Macdonell, Richard, King, John, Butzkueven, Helmut, Lechner-Scott, Jeannette, Saines, Noel, Slee, Mark, Plummer, Chris, Willekens, Barbara, Vanopdenbosch, Ludo, Belachew, Shibeshih, Phan-Ba, Rémy, Delvaux, Valérie, Bissay, Veronique, Debruyne, Jan, Decoo, Danny, Crols, Roeland, Symons, Anoek, Nagels, Guy, Van Pesch, Vincent, Sindic, Christian, Dubois, Benedicte, Medaer, Robert, D'Hooghe, Marie, Guillaume, Daniel, De Smet, Eric, Seeldrayers, Pierrette, Lysandropoulos, Andreas, Vokaer, Mathieu, Geens, Karine, Willems, Christina, Denayer, Pierre, Bureau, Michel, Retif, Cecile, Dupuis, Michel, Bouquiaux, Olivier, Vanderdonckt, Patrick, van Landegem, William, Caekebeke, Jo, Van Ingelghem, Erwin, Peeters, Katelijne, Gerard, Pascale, de Noordhout, Alain Maertens, Desfontaines, Philippe, Urbain, Etienne, Declercq, Inge, Van Wijmeersch, Bart, Vanroose, Erwin, Wibail, Alain, Barthomolé, Emmanuel, Ursell, Melanie, Sweet, Margaret Elizabeth, Howse, David, Jichici, Draga, Shawush, Melad, Namaka, Mike, Traboulsee, Anthony, Hashimoto, Stan, Lo, Raymond, Marchetti, Paul, Lapierre, Yves, Jacques, Francois, MacLean, Gregg, Bhan, Virender, Duquette, Pierre, Stewart, Bradley, Paulseth, John, Kremenchutzky, Marcelo, Vorobeychik, Galina, O'Connor, Paul, Grand'Maison, François, Havrdova, Eva, Meluzinová, Eva, Valis, Martin, Talab, Radomír, Stourac, Pavel, Zapletalová, Olga, Dufek, Michal, Sládková, Vladimíra, Novotna, Alena, Vancurová, Romana, Lhotaková, Libuse, Fiedler, Jiri, Vachova, Marta, Dolezil, David, Stetkarova, Ivana, Rehankova, Adela, Psenica, Petr, Ulehlova, Veronika, Feketova, Sona, Skoda, Ondrej, Färkkilä, Markus, Taneli, Sarasoja, Koivisto, Keijo, Seppä, Juha Matti, Airas, Laura, Elovaara, Irina, Hartikainen, Päivi, Pirttila, Tuula, Louchart, Pierre, Ille, Olivier, Thenint, Jean philippe, Godet, Etienne, Vioud, Marcel Maillet, Colamarino, Renato, Gugenheim, Michel, Grimaud, Jerome, Kopf, Audrey, Billy, Christophe, Huttin, Bernard, Borsotti, Jean paul, Devos, Philippe, Kendjuo, Jean bertin N, Verier, Albert, Chapuis, Stephane, Daluzeau, Nathalie, Angibaud, Gilles, Uriot, Marie-Sylvie Artaud, Ziegler, François, Sellal, François, Moulignier, Antoine, Lavenu, Isabelle, Ismail, Samir, Devy, Richard, Suceveanu, Manuel, Wagner, Marc, Marcel, Sebastien, Derouiche, Faycal, Mostoufizadehghalamfarsa, Sohrab, Delalande, Sophie, Ruggieri, Irene, Van Nieuwenhuyse, Catherine Bossu, Nifle, Chantal, Ondze, Basile, Vasilescu, Carmen Gurau, Vongsouthi, Cyrille, Coustans, Marc, Anne, Olivier, Amevigbe, Josephine, Servan, Jerome, Merienne, Marc, Eck, Philippe, Berroir, Stephane, Busson, Philippe, Barroso, Bruno, Larrieu, Jean-Marc, Giendaj, Catherine Louvet, Malkoun, Imad, Hautecoeur, Patrick, Kwiatkowski, Arnaud, Pouliquen, Andre, Garrigues, Guillaume, Delerue, Olivier, Giraud, Pierric, Gere, Julien, Vaunaize, Jean, Dereeper, Olivier, Seiller, Nicolas, Alsassa, Roger, Vlaicu, Mihaela, Neuville, Veronique, Faucheux, Jean Marc, Bernady, Patricia, Fanjaud, Guy, Viallet, François, Schroeter, Michael, Schlemilch-Paschen, Sylke, Lange, Thomas, Bohr, Kin-Arno, Jendroska, Klaus, Rehkopf, Elisabeth, Bergmann, Arnfin, Kleinschnitz, Christoph, Postert, Thomas, Scholz, Peter, Mauz, Uwe, Stratmann, Hubert, Siefjediers, Veneta, Prantl, Martin, Gehring, Klaus, Zellner, Ruth, Junge, Kathrin, Zellner, Anton, Bacay, Valerina, Schlegel, Eugen, Polzer, Udo, Strauss, Erik, Link, Andreas, Stenzel, Christoph, Freidel, Matthias, Drews, Joachim, Neudert, Christian, Schmitz, Frank, Jaeger, Joachim, Masri, Said, Heuberger, Wolfgang, Trausch, Beate, Ruhnke, Oliver, Scarel, Serena, Bach, Kathlen, Ernst, Michael, Landefeld, Harald, Richter, Nils, Schmidt, Stephan, Krause, Michaela, Dressel, Alezander, Ruth, Roland, Anvari, Kerstin, Gossling, Jens, Schenk, Christoph, Tiedge, Oliver, Bode, Lutz, Eder, Hans-Thomas, Pfeffer, Oliver, Krug, Reinhard, Lassek, Christoph, Fleischer, Eberhard, Meuth, Sven, Klotz, Luisa Hildegard, Peglau, Ines, Kukowski, Borries, Herting, Birgit, Guthke, Kersten, Schierenbeck, Jurgen, Brockmeier, Bernd, Albrecht, Holger, Wuttke, Matthias, Augspach-Hofmann, Regine, Gunther, Stefan, Redbrake, Martin, Franke, Christian, Buchner, Klaus, Gratz, Thomas, Horn, Rolf, Doemges, Frank, Schreiber, Martin, Brosch, Thomas, Horn, Markus, Kittlitz, Matthias, Vulturius, Gabriele, Hinse, Paul, Malessa, Rolf, Wiehler, Stephan, Katsarava, Zaza, Kastrup, Oliver, Kausch, Ulrich, Gullekes, Martin, Fickinger, Markus, Wenzel, Wilhelm, Botefur, Ingolf C., Reifschneider, Gerd, Rauer, Sebastian, Lang, Michael, Harms, Lutz, Eckhardt, Ulrich, Cursiefen, Simone, Linker, Ralf, Angstwurm, Klemens, Haas, Judith, Schuetze, Ivo, Rohm, Eva, Stienker-Fisse, H., Sailer, Michael, Bohringer, Johannes, Maurer, Mathias, Bause, Eberhard, Wersching, Ronald, Dachsel, Reinhardt, Domke, Sylke, Hoffman, Frank, Tackenberg, Bjorn, Roch, Kerstin, Ziebold, Uwe, Kallmann, Boris, Buehler, Bernhard, Faiss, Judith, Faiss, Juergen, Schimrigk, Sebastian, Menges, Christian, Knop, Karl Christian, Koehler, Wolfgang, Siever, Arno, Bufler, Johannes, Gramsl, Georg, Kuhnler, Benedicta, Maschke, Matthias, Stogbauer, Florian, Staude, Lisa, Bethke, Florian, Bitsch, Andreas, Harmjanz, Arndt D., Windsheimer, Jorg, Kieseier, Bernd C., Berkenfeld, Ralf, Tumani, Hayrettin, Kirsch, Michael, Wildemann, Brigitte, Daniels, Regina, Gottwald, Klaus, Elias, Wolfgang-Gerhard, Hoffmann, Olaf, Schwab, Matthias, Pilz, Christopher, Klostermann, Fabian, Hellwig, Kerstin, Berthele, Achim, Bayas, Antonios, Molitor, Daniel, Grothe, Christoph, Wagner, Bert, Karageorgiou, Klimentini, Mitsikostas, Dimosthenis, Kodounis, Antonios, Plaitakis, Andreas, Papadimitriou, Alexandros, Grigoriadis, Nikolaos, Vlaikidis, Nikolaos, Koutlas, Evaggelos, Kyritsis, Athanassios, Papathanassopoulos, Panagiotis, Makris, Nikolaos, Tavernarakis, Antonios, Scarpini, Elio, Montanari, Enrico, Marrosu, Maria Giovanna, Trojano, Maria, Amato, Maria Pia, Rottoli, Mariarosa, Lugaresi, Alessandra, Florio, Ciro, Gasperini, Claudio, Grimaldi, Luigi, Millefiorini, Enrico, Koudriavtseva, Tatiana, Perla, Franco, Mantegazza, Renato, Bertolotto, Antonio, Ghezzi, Angelo, Aguilar, Sandra Quinones, Eisenberg, Eli Skromne, Lopez, Leondardo Llamas, Estudillo, Rocio Marquez, Schrijver, H.M., Wittebol, M.C., Baart, J.C., van Golde, A.E.L., Hengstman, G.J.D., Pop, P.H.M., Bos (Geldrop), M., Medaer, R., Schyns-Soeterboek, Angelique, van der Zwart, A., van Diepen, A.J.H., Verheul, G.A.M., Verhagen, W.I.M., Bos (Helmond), M., Witjes, R.J.G.M., Sinnige, L.G.F., van Munster, E.Th.L., Sanders, E.A.C.M., van Dijl, Ron, Hupperts, R.M.M., Frequin, S.T.F.M., Visser, L.H., Henselmans, J.M.L., Moll, J.W.B., Midgard, Rune, Myhr, Kjell Morten, Edland, Astrid, Telstad, Wenche, Hognestad, Tone, Lund, Christian, Hovdal, Harald, Kamaljit, Kaur, Schepel, Jan, Hogenesch, Roelfien Ida, Schüler, Stephan, Odeh, Francis, Alstadhaug, Karl B., Korsgaard, Olav, Farbu, Elisabeth, Ingvaldsen, Teis Barclay, Soares (SCO), Diana, Rente, José, Guerra, José Manuel Costa, Morganho, Armando, Leitão, António, de Sá, João, Sá, Maria José, Marques, Pinto, Veloso, Mário, Baptista, Miguel Viana, Szilasiová, Jarmila, Copikova-Cudrakova, Daniela, Prochazkova, Lubica, Klimová, Eleonóra, Donath, Vladimir, Brozman, Miroslav, Ramo, Cristina, Ruiz, Domingo Pérez, Hernández, Carmen Calles, Sola, María Eugenia Marzo, Moro, Roberto Suarez, Vidal, Jose Antonio, Rodríguez, Ana Belén Caminero, Ozaeta, Gisela Martin, Nadal, Jordi Batlle, Esquide, Amaya Alvarez de Arcaya, Urtaza, Javier Olascoaga, Martínez-Yélamos, Sergio, Arbizu, Txomin, Torrenta, Lluis Ramio i, Boggild, Mike, Wilson, Martin, Al-Araji, Adnan, Nicholas, Richard, Harrower, Timothy, Redmond, Ian, Wolf, Tilo, Osei-Bonsu, Michael, Mazibrada, Gordon, Rog, David, Cottrell, David, Constantinescu, Cris, Gray, Orla, Belhag, Mohamed, Shehu, Abdullah, Rashid, Waqar, Duddy, Martin, Kappos, Ludwig, Wiendl, Heinz, Spelman, Tim, Pellegrini, Fabio, Chen, Yi, Dong, Qunming, and Koendgen, Harold
- Published
- 2018
- Full Text
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30. Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study
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Achiron, Anat, Achtnichts, Lutz, Agan, Kadriye, Akman-Demir, Gulsen, Allen, Alison B, Antel, Jack P, Antiguedad, Alfredo Rodriguez, Apperson, Michelle, Applebee, Angela M, Ayuso, Guillermo Izquierdo, Baba, Masayuki, Bajenaru, Ovidiu, Balasa, Rodica, Balci, Belgin Petek, Barnett, Michael, Bass, Ann, Becker, Veit U, Bejinariu, Mihaela, Bergh, Florian Then, Bergmann, Arnfin, Bernitsas, Evanthia, Berthele, Achim, Bhan, Virender, Bischof, Felix, Bjork, Randall John, Blevins, Gregg, Boehringer, Matthias, Boerner, Thomas, Bonek, Robert, Bowen, James D, Bowling, Allen, Boyko, Alexey N, Boz, Cavit, Bracknies, Vera, Braune, Stefan, Brescia Morra, Vincenzo, Brochet, Bruno, Brola, Waldemar, Brownstone, Paul Kenneth, Brozman, Miroslav, Brunet, Donald, Buraga, Ioan, Burnett, Margaret, Buttmann, Mathias, Butzkueven, Helmut, Cahill, Jonathan, Calkwood, Jonathan C, Camu, William, Cascione, Mark, Castelnovo, Giovani, Centonze, Diego, Cerqueira, Joao, Chan, Andrew, Cimprichova, Andrea, Cohan, Stanley, Comi, Giancarlo, Conway, Jill, Cooper, Joanna A, Corboy, John, Correale, Jorge, Costell, Brian, Cottrell, David A, Coyle, Patricia K, Craner, Matthew, Cui, Liying, Cunha, Luis, Czlonkowska, Anna, da Silva, Ana Martins, de Sa, Joao, de Seze, Jérôme, Debouverie, Marc, Debruyne, Jan, Decoo, Danny, Defer, Gilles, Derfuss, Tobias, Deri, Norma H, Dihenia, Bhupesh, Dioszeghy, Peter, Donath, Vladimir, Dubois, Benedicte, Duddy, Martin, Duquette, Pierre, Edan, Gilles, Efendi, Husnu, Elias, Stanton, Emrich, Peter J, Estruch, Bonaventura Casanova, Evdoshenko, Evgeniy P, Faiss, Juergen, Fedyanin, Alexander S, Feneberg, Wolfgang, Fermont, Jiske, Fernandez, Oscar Fernandez, Ferrer, Francisco Coret, Fink, Katharina, Ford, Helen, Ford, Corey, Francia, Ada, Freedman, Mark, Frishberg, Benjamin, Galgani, Simonetta, Garmany, George P, Gehring, Klaus, Gitt, Jeffrey, Gobbi, Claudio, Goldstick, Lawrence P, Gonzalez, Rafael Arroyo, Grandmaison, Francois, Grigoriadis, Nikolaos, Grigorova, Olga, Grimaldi, Luigi Maria Edoardo, Gross, Jeffrey, Gross-Paju, Katrin, Gudesblatt, Mark, Guillaume, Daniel, Haas, Judith, Hancinova, Viera, Hancu, Anca, Hardiman, Orla, Harmjanz, Arndt, Heidenreich, Fedor R, Hengstman, G J D, Herbert, Joseph, Herring, Mark, Hodgkinson, Suzanne, Hoffmann, Olaf M, Hofmann, Werner E, Honeycutt, William D, Hua, Le Hanh, Huang, Dehui, Huang, Yining, Huang, DeRen, Hupperts, Raymond, Imre, Piroska, Jacobs, Alan Keith, Jakab, Gabor, Jasinska, Elzbieta, Kaida, Kenichi, Kalnina, Jolanta, Kaprelyan, Ara, Karelis, Guntis, Karussis, Dimitrios, Katz, Amos, Khabirov, Farit A, Khatri, Bhupendra, Kimura, Takashi, Kister, Ilya, Kizlaitiene, Rasa, Klimova, Eleonora, Koehler, Juergen, Komatineni, Aparna, Kornhuber, Anselm, Kovacs, Krisztina, Koves, Agnes, Kozubski, Wojciech, Krastev, Georgi, Krupp, Lauren B, Kurca, Egon, Lassek, Christoph, Laureys, Guy, Lee, Liesly, Lensch, Eckart, Leutmezer, Fritz, Li, Hongzeng, Linker, Ralf A, Linnebank, Michael, Liskova, Petra, Llanera, Cristina, Lu, Jiahong, Lutterotti, Andreas, Lycke, Jan, Macdonell, Richard, Maciejowski, Maciej, Maeurer, Mathias, Magzhanov, Rim V, Maida, Eva-Maria, Malciene, Lina, Mao-Draayer, Yang, Marfia, Girolama Alessandra, Markowitz, Clyde, Mastorodimos, Vasileios, Matyas, Klotild, Meca-Lallana, Jose, Merino, Juan Antonio Garcia, Mihetiu, Ioan Gheorghe, Milanov, Ivan, Miller, Aaron E, Millers, Andrejs, Mirabella, Massimiliano, Mizuno, Masanori, Montalban, Xavier, Montoya, Lilina, Mori, Masahiro, Mueller, Stefanie, Nakahara, Jin, Nakatsuji, Yuji, Newsome, Scott, Nicholas, Richard, Nielsen, A Scott, Nikfekr, Esmaeil, Nocentini, Ugo, Nohara, Chiyoko, Nomura, Kyoichi, Odinak, Miroslav M, Olsson, Tomas, van Oosten, B W, Oreja-Guevara, Celia, Oschmann, Patrick, Overell, James, Pachner, Andrew, Panczel, Gyula, Pandolfo, Massimo, Papeix, Caroline, Patrucco, Liliana, Pelletier, Jean, Piedrabuena, Raul, Pless, Misha, Polzer, Udo, Pozsegovits, Krisztian, Rastenyte, Daiva, Rauer, Sebastian, Reifschneider, Gerd, Rey, Roberto, Rizvi, Syed A, Robertson, Derrick, Rodriguez, Jose Martinez, Rog, David, Roshanisefat, Homayoun, Rowe, Vernon, Rozsa, Csilla, Rubin, Susan, Rusek, Stanislaw, Saccà, Francesco, Saida, Takahiko, Salgado, Antonio Vasco, Sanchez, Victoria Eugenia Fernandez, Sanders, Kalina, Satori, Maria, Sazonov, Denis V, Scarpini, Elio Angelo, Schlegel, Eugen, Schluep, Myriam, Schmidt, Stephan, Scholz, Erich, Schrijver, H M, Schwab, Matthias, Schwartz, Raymond, Scott, James, Selmaj, Krzysztof, Shafer, Stuart, Sharrack, Basil, Shchukin, Ivan A, Shimizu, Yuko, Shotekov, Penko, Siever, Arno, Sigel, Karl-Otto, Silliman, Scott, Simo, Magdolna, Simu, Mihaela, Sinay, Vladimiro, Siquier, Antonio Escartin, Siva, Aksel, Skoda, Ondrej, Solomon, Andrew, Stangel, Martin, Stefoski, Dusan, Steingo, Brian, Stolyarov, Igor D, Stourac, Pavel, Strassburger-Krogias, Katrin, Strauss, Erik, Stuve, Olaf, Tarnev, Ivaylo, Tavernarakis, Antonios, Tello, Cristina Ramo, Terzi, Murat, Ticha, Veronika, Ticmeanu, Marina, Tiel-Wilck, Klaus, Toomsoo, Toomas, Tubridy, Niall, Tullman, Mark J, Tumani, Hayrettin, Turcani, Peter, Turner, Ben, Uccelli, Antonio, Urtaza, Francisco Javier Olascoaga, Vachova, Marta, Valikovics, Attila, Walter, Silke, Van Wijmeersch, Bart, Vanopdenbosch, Ludo, Weber, Joerg R, Weiss, Sara, Weissert, Robert, Vermersch, Patrick, West, Timothy, Wiendl, Heinz, Wiertlewski, Sandrine, Wildemann, Brigitte, Willekens, Barbara, Visser, L H, Vorobeychik, Galina, Xu, Xianhao, Yamamura, Takashi, Yang, Yi N, Yelamos, Sergio Martinez, Yeung, Michael, Zacharias, Alan, Zelkowitz, Marvin, Zettl, Uwe, Zhang, Meini, Zhou, Hongyu, Zieman, Ulf, Ziemssen, Tjalf, Kappos, Ludwig, Bar-Or, Amit, Cree, Bruce A C, Fox, Robert J, Giovannoni, Gavin, Gold, Ralf, Arnold, Douglas L, Arnould, Sophie, Scherz, Tatiana, Wolf, Christian, Wallström, Erik, and Dahlke, Frank
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- 2018
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31. Correction to: Clinical and demographic characteristics of primary progressive multiple sclerosis in Argentina: Argentinean registry cohort study (RelevarEM)
- Author
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Alonso, Ricardo, Quarracino, Cecilia, Eizaguirre, Bárbara, Cohen, Leila, Silva, Berenice, Pita, Cecilia, Rojas, Juan Ignacio, Pappolla, Agustín, Miguez, Jimena, Patrucco, Liliana, Cristiano, Edgardo, Vrech, Carlos, Volman, Gabriel, Silva, Emanuel, Barboza, Andres, Deri, Norma, Tkachuk, Verónica, Zanga, Gisela, Tavolini, Dario, Saladino, María Laura, Luetic, Geraldine, Menichini, María Laura, Carnero Contentti, Edgar, López, Pablo, Steinberg, Judith, Divi, Pablo, Hryb, Javier, Pinheiro, Amelia Alves, Carra, Adriana, Balbuena, María Eugenia, Lázaro, Luciana, Liguori, Nora Fernández, and Garcea, Orlando
- Published
- 2021
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32. The risk of secondary progressive multiple sclerosis is geographically determined but modifiable
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Sharmin, Sifat, primary, Roos, Izanne, additional, Simpson-Yap, Steve, additional, Malpas, Charles, additional, Sánchez, Marina M, additional, Ozakbas, Serkan, additional, Horakova, Dana, additional, Havrdova, Eva K, additional, Patti, Francesco, additional, Alroughani, Raed, additional, Izquierdo, Guillermo, additional, Eichau, Sara, additional, Boz, Cavit, additional, Zakaria, Magd, additional, Onofrj, Marco, additional, Lugaresi, Alessandra, additional, Weinstock-Guttman, Bianca, additional, Prat, Alexandre, additional, Girard, Marc, additional, Duquette, Pierre, additional, Terzi, Murat, additional, Amato, Maria Pia, additional, Karabudak, Rana, additional, Grand’Maison, Francois, additional, Khoury, Samia J, additional, Grammond, Pierre, additional, Lechner-Scott, Jeannette, additional, Buzzard, Katherine, additional, Skibina, Olga, additional, van der Walt, Anneke, additional, Butzkueven, Helmut, additional, Turkoglu, Recai, additional, Altintas, Ayse, additional, Maimone, Davide, additional, Kermode, Allan, additional, Shalaby, Nevin, additional, Pesch, Vincent V, additional, Butler, Ernest, additional, Sidhom, Youssef, additional, Gouider, Riadh, additional, Mrabet, Saloua, additional, Gerlach, Oliver, additional, Soysal, Aysun, additional, Barnett, Michael, additional, Kuhle, Jens, additional, Hughes, Stella, additional, Sa, Maria J, additional, Hodgkinson, Suzanne, additional, Oreja-Guevara, Celia, additional, Ampapa, Radek, additional, Petersen, Thor, additional, Ramo-Tello, Cristina, additional, Spitaleri, Daniele, additional, McCombe, Pamela, additional, Taylor, Bruce, additional, Prevost, Julie, additional, Foschi, Matteo, additional, Slee, Mark, additional, McGuigan, Chris, additional, Laureys, Guy, additional, Hijfte, Liesbeth V, additional, de Gans, Koen, additional, Solaro, Claudio, additional, Oh, Jiwon, additional, Macdonell, Richard, additional, Aguera-Morales, Eduardo, additional, Singhal, Bhim, additional, Gray, Orla, additional, Garber, Justin, additional, Wijmeersch, Bart V, additional, Simu, Mihaela, additional, Castillo-Triviño, Tamara, additional, Sanchez-Menoyo, Jose L, additional, Khurana, Dheeraj, additional, Al-Asmi, Abdullah, additional, Al-Harbi, Talal, additional, Deri, Norma, additional, Fragoso, Yara, additional, Lalive, Patrice H, additional, Sinnige, L G F, additional, Shaw, Cameron, additional, Shuey, Neil, additional, Csepany, Tunde, additional, Sempere, Angel P, additional, Moore, Fraser, additional, Decoo, Danny, additional, Willekens, Barbara, additional, Gobbi, Claudio, additional, Massey, Jennifer, additional, Hardy, Todd, additional, Parratt, John, additional, and Kalincik, Tomas, additional
- Published
- 2023
- Full Text
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33. Variability of the response to immunotherapy among subgroups of patients with multiple sclerosis
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Altıntaş, Ayşe (ORCID 0000-0002-8524-5087 & YÖK ID 11611), Diouf, Ibrahima; Malpas, Charles B.; Sharmin, Sifat; Roos, Izanne; Horakova, Dana; Havrdova, Eva Kubala; Patti, Francesco; Shaygannejad, Vahid; Ozakbas, Serkan; Izquierdo, Guillermo; Eichau, Sara; Onofrj, Marco; Lugaresi, Alessandra; Alroughani, Raed; Prat, Alexandre; Girard, Marc; Duquette, Pierre; Terzi, Murat; Boz, Cavit; Grand'Maison, Francois; Hamdy, Sherif; Sola, Patrizia; Ferraro, Diana; Grammond, Pierre; Turkoglu, Recai; Buzzard, Katherine; Skibina, Olga; Yamout, Bassem; Gerlach, Oliver; van Pesch, Vincent; Blanco, Yolanda; Maimone, Davide; Lechner-Scott, Jeannette; Bergamaschi, Roberto; Karabudak, Rana; Iuliano, Gerardo; McGuigan, Chris; Cartechini, Elisabetta; Barnett, Michael; Hughes, Stella; Sa, Maria Jose; Solaro, Claudio; Kappos, Ludwig; Ramo-Tello, Cristina; Cristiano, Edgardo; Hodgkinson, Suzanne; Spitaleri, Daniele; Soysal, Aysun; Petersen, Thor; Slee, Mark; Butler, Ernest; Granella, Franco; de Gans, Koen; McCombe, Pamela; Ampapa, Radek; Van Wijmeersch, Bart; van der Walt, Anneke; Butzkueven, Helmut; Prevost, Julie; Sinnige, L. G. F.; Sanchez-Menoyo, Jose Luis; Vucic, Steve; Laureys, Guy; Van Hijfte, Liesbeth; Khurana, Dheeraj; Macdonell, Richard; Gouider, Riadh; Castillo-Trivino, Tamara; Gray, Orla; Aguera-Morales, Eduardo; Al-Asmi, Abdullah; Shaw, Cameron; Deri, Norma; Al-Harbi, Talal; Fragoso, Yara; Csepany, Tunde; Sempere, Angel Perez; Trevino-Frenk, Irene; Schepel, Jan; Moore, Fraser; Kalincik, Tomas, Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM), School of Medicine, Altıntaş, Ayşe (ORCID 0000-0002-8524-5087 & YÖK ID 11611), Diouf, Ibrahima; Malpas, Charles B.; Sharmin, Sifat; Roos, Izanne; Horakova, Dana; Havrdova, Eva Kubala; Patti, Francesco; Shaygannejad, Vahid; Ozakbas, Serkan; Izquierdo, Guillermo; Eichau, Sara; Onofrj, Marco; Lugaresi, Alessandra; Alroughani, Raed; Prat, Alexandre; Girard, Marc; Duquette, Pierre; Terzi, Murat; Boz, Cavit; Grand'Maison, Francois; Hamdy, Sherif; Sola, Patrizia; Ferraro, Diana; Grammond, Pierre; Turkoglu, Recai; Buzzard, Katherine; Skibina, Olga; Yamout, Bassem; Gerlach, Oliver; van Pesch, Vincent; Blanco, Yolanda; Maimone, Davide; Lechner-Scott, Jeannette; Bergamaschi, Roberto; Karabudak, Rana; Iuliano, Gerardo; McGuigan, Chris; Cartechini, Elisabetta; Barnett, Michael; Hughes, Stella; Sa, Maria Jose; Solaro, Claudio; Kappos, Ludwig; Ramo-Tello, Cristina; Cristiano, Edgardo; Hodgkinson, Suzanne; Spitaleri, Daniele; Soysal, Aysun; Petersen, Thor; Slee, Mark; Butler, Ernest; Granella, Franco; de Gans, Koen; McCombe, Pamela; Ampapa, Radek; Van Wijmeersch, Bart; van der Walt, Anneke; Butzkueven, Helmut; Prevost, Julie; Sinnige, L. G. F.; Sanchez-Menoyo, Jose Luis; Vucic, Steve; Laureys, Guy; Van Hijfte, Liesbeth; Khurana, Dheeraj; Macdonell, Richard; Gouider, Riadh; Castillo-Trivino, Tamara; Gray, Orla; Aguera-Morales, Eduardo; Al-Asmi, Abdullah; Shaw, Cameron; Deri, Norma; Al-Harbi, Talal; Fragoso, Yara; Csepany, Tunde; Sempere, Angel Perez; Trevino-Frenk, Irene; Schepel, Jan; Moore, Fraser; Kalincik, Tomas, Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM), and School of Medicine
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Background and purpose: This study assessed the effect of patient characteristics on the response to disease-modifying therapy (DMT) in multiple sclerosis (MS). Methods: We extracted data from 61,810 patients from 135 centers across 35 countries from the MSBase registry. The selection criteria were: clinically isolated syndrome or definite MS, follow-up ? 1 year, and Expanded Disability Status Scale (EDSS) score ? 3, with ?1 score recorded per year. Marginal structural models with interaction terms were used to compare the hazards of 12-month confirmed worsening and improvement of disability, and the incidence of relapses between treated and untreated patients stratified by their characteristics. Results: Among 24,344 patients with relapsing MS, those on DMTs experienced 48% reduction in relapse incidence (hazard ratio [HR] = 0.52, 95% confidence interval [CI] = 0.45–0.60), 46% lower risk of disability worsening (HR = 0.54, 95% CI = 0.41–0.71), and 32% greater chance of disability improvement (HR = 1.32, 95% CI = 1.09–1.59). The effect of DMTs on EDSS worsening and improvement and the risk of relapses was attenuated with more severe disability. The magnitude of the effect of DMT on suppressing relapses declined with higher prior relapse rate and prior cerebral magnetic resonance imaging activity. We did not find any evidence for the effect of age on the effectiveness of DMT. After inclusion of 1985 participants with progressive MS, the effect of DMT on disability mostly depended on MS phenotype, whereas its effect on relapses was driven mainly by prior relapse activity. Conclusions: DMT is generally most effective among patients with lower disability and in relapsing MS phenotypes. There is no evidence of attenuation of the effect of DMT with age., This study was financially supported by the National Health and Medical Research Council of Australia (1129189, 1140766, 1080518).
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34. Bases racionales de prescripción para médicos neurólogos
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Orellana, Lucas, Aleman, Alberto, Barboza, Andrés, Bernater, Ricardo, Demey, Ignacio, Deri, Norma, Fumagalli, Ana Isabel, Kriebaum, Martín, Martinez, Alejandra, Martinez, Oscar, Papayannis, Cristina, Parada Marcilla, Marcela, Rojas, Galeno, Romano, Lucas Martin, Romano, Marina, Saidon, Patricia, and Steinberg, Judith
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- 2016
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35. Comparative effectiveness in multiple sclerosis: A methodological comparison
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Roos, Izanne, primary, Diouf, Ibrahima, additional, Sharmin, Sifat, additional, Horakova, Dana, additional, Havrdova, Eva Kubala, additional, Patti, Francesco, additional, Shaygannejad, Vahid, additional, Ozakbas, Serkan, additional, Izquierdo, Guillermo, additional, Eichau, Sara, additional, Onofrj, Marco, additional, Lugaresi, Alessandra, additional, Alroughani, Raed, additional, Prat, Alexandre, additional, Girard, Marc, additional, Duquette, Pierre, additional, Terzi, Murat, additional, Boz, Cavit, additional, Grand’Maison, Francois, additional, Sola, Patrizia, additional, Ferraro, Diana, additional, Grammond, Pierre, additional, Turkoglu, Recai, additional, Buzzard, Katherine, additional, Skibina, Olga, additional, Yamou, Bassem, additional, Altintas, Ayse, additional, Gerlach, Oliver, additional, van Pesch, Vincent, additional, Blanco, Yolanda, additional, Maimone, Davide, additional, Lechner-Scott, Jeannette, additional, Bergamaschi, Roberto, additional, Karabudak, Rana, additional, McGuigan, Chris, additional, Cartechini, Elisabetta, additional, Barnett, Michael, additional, Hughes, Stella, additional, Sa, Maria José, additional, Solaro, Claudio, additional, Ramo-Tello, Cristina, additional, Hodgkinson, Suzanne, additional, Spitaleri, Daniele, additional, Soysal, Aysun, additional, Petersen, Thor, additional, Granella, Franco, additional, de Gans, Koen, additional, McCombe, Pamela, additional, Ampapa, Radek, additional, Van Wijmeersch, Bart, additional, van der Walt, Anneke, additional, Butzkueven, Helmut, additional, Prevost, Julie, additional, Sanchez-Menoyo, Jose Luis, additional, Laureys, Guy, additional, Gouider, Riadh, additional, Castillo-Triviño, Tamara, additional, Gray, Orla, additional, Aguera-Morales, Eduardo, additional, Al-Asmi, Abdullah, additional, Shaw, Cameron, additional, Deri, Norma, additional, Al-Harbi, Talal, additional, Fragoso, Yara, additional, Csepany, Tunde, additional, Sempere, Angel Perez, additional, Trevino-Frenk, Irene, additional, Schepel, Jan, additional, Moore, Fraser, additional, Malpas, Charles, additional, and Kalincik, Tomas, additional
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- 2023
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36. Variability of the response to immunotherapy among subgroups of patients with multiple sclerosis
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Diouf, Ibrahima, primary, Malpas, Charles B., additional, Sharmin, Sifat, additional, Roos, Izanne, additional, Horakova, Dana, additional, Havrdova, Eva Kubala, additional, Patti, Francesco, additional, Shaygannejad, Vahid, additional, Ozakbas, Serkan, additional, Izquierdo, Guillermo, additional, Eichau, Sara, additional, Onofrj, Marco, additional, Lugaresi, Alessandra, additional, Alroughani, Raed, additional, Prat, Alexandre, additional, Girard, Marc, additional, Duquette, Pierre, additional, Terzi, Murat, additional, Boz, Cavit, additional, Grand'Maison, Francois, additional, Hamdy, Sherif, additional, Sola, Patrizia, additional, Ferraro, Diana, additional, Grammond, Pierre, additional, Turkoglu, Recai, additional, Buzzard, Katherine, additional, Skibina, Olga, additional, Yamout, Bassem, additional, Altintas, Ayse, additional, Gerlach, Oliver, additional, van Pesch, Vincent, additional, Blanco, Yolanda, additional, Maimone, Davide, additional, Lechner‐Scott, Jeannette, additional, Bergamaschi, Roberto, additional, Karabudak, Rana, additional, Iuliano, Gerardo, additional, McGuigan, Chris, additional, Cartechini, Elisabetta, additional, Barnett, Michael, additional, Hughes, Stella, additional, Sa, Maria José, additional, Solaro, Claudio, additional, Kappos, Ludwig, additional, Ramo‐Tello, Cristina, additional, Cristiano, Edgardo, additional, Hodgkinson, Suzanne, additional, Spitaleri, Daniele, additional, Soysal, Aysun, additional, Petersen, Thor, additional, Slee, Mark, additional, Butler, Ernest, additional, Granella, Franco, additional, de Gans, Koen, additional, McCombe, Pamela, additional, Ampapa, Radek, additional, Van Wijmeersch, Bart, additional, van der Walt, Anneke, additional, Butzkueven, Helmut, additional, Prevost, Julie, additional, Sinnige, L. G. F., additional, Sanchez‐Menoyo, Jose Luis, additional, Vucic, Steve, additional, Laureys, Guy, additional, Van Hijfte, Liesbeth, additional, Khurana, Dheeraj, additional, Macdonell, Richard, additional, Gouider, Riadh, additional, Castillo‐Triviño, Tamara, additional, Gray, Orla, additional, Aguera‐Morales, Eduardo, additional, Al‐Asmi, Abdullah, additional, Shaw, Cameron, additional, Deri, Norma, additional, Al‐Harbi, Talal, additional, Fragoso, Yara, additional, Csepany, Tunde, additional, Perez Sempere, Angel, additional, Trevino‐Frenk, Irene, additional, Schepel, Jan, additional, Moore, Fraser, additional, and Kalincik, Tomas, additional
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- 2023
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37. Achieving no evidence of disease activity-3 in highly active multiple sclerosis patients treated with cladribine and monoclonal antibodies
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Alonso, Ricardo, primary, Casas, Magdalena, additional, Lazaro, Luciana, additional, Fernandez Liguori, Nora, additional, Pita, Cecilia, additional, Cohen, Leila, additional, Rojas, Juan Ignacio, additional, Pappolla, Agustín, additional, Patrucco, Liliana, additional, Cristiano, Edgardo, additional, Burgos, Marcos, additional, Vrech, Carlos, additional, Piedrabuena, Raul, additional, Pablo, Lopez, additional, Deri, Norma, additional, Luetic, Geraldine, additional, Miguez, Jimena, additional, Cabrera, Mariela, additional, Martinez, Alejandra, additional, Zanga, Gisela, additional, Tkachuk, Verónica, additional, Tizio, Santiago, additional, Carnero Contentti, Edgar, additional, Knorre, Eduardo, additional, Leguizamon, Felisa, additional, Mainella, Carolina, additional, Nofal, Pedro, additional, Liwacki, Susana, additional, Hryb, Javier, additional, Menichini, Maria, additional, Pestchanker, Claudia, additional, Alonso, Marina, additional, Garcea, Orlando, additional, and Silva, Berenice, additional
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- 2023
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38. Comparative effectiveness of autologous hematopoietic stem cell transplant vs Fingolimod, Natalizumab, and Ocrelizumab in highly active relapsing-remitting multiple sclerosis
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Kalincik, Tomas, Sharmin, Sifat, Roos, Izanne, Freedman, Mark S., Atkins, Harold, Burman, Joachim, Massey, Jennifer, Sutton, Ian, Withers, Barbara, Macdonell, Richard, Grigg, Andrew, Torkildsen, Øivind, Bo, Lars, Lehmann, Anne Kristine, Havrdova, Eva Kubala, Krasulova, Eva, Trněný, Marek, Kozak, Tomas, van der Walt, Anneke, Butzkueven, Helmut, McCombe, Pamela, Skibina, Olga, Lechner-Scott, Jeannette, Willekens, Barbara, Cartechini, Elisabetta, Ozakbas, Serkan, Alroughani, Raed, Kuhle, Jens, Patti, Francesco, Duquette, Pierre, Lugaresi, Alessandra, Khoury, Samia J., Slee, Mark, Turkoglu, Recai, Hodgkinson, Suzanne, John, Nevin, Maimone, Davide, Sa, Maria Jose, van Pesch, Vincent, Gerlach, Oliver, Laureys, Guy, Van Hijfte, Liesbeth, Karabudak, Rana, Spitaleri, Daniele, Csepany, Tunde, Gouider, Riadh, Castillo-Triviño, Tamara, Taylor, Bruce, Sharrack, Basil, Snowden, John A., Horakova, Dana, Buzzard, Katherine, Terzi, Murat, Prat, Alexandre, Girard, Marc, Grammond, Pierre, Barnett, Michael, Stewart, Grace, Onofrj, Marco, Izquierdo, Guillermo, Eichau, Sara, Grand'Maison, Francois, Prevost, Julie, Van Wijmeersch, Bart, Amato, Maria Pia, Shaygannejad, Vahid, Boz, Cavit, Bolaños, Ricardo Fernandez, Soysal, Aysun, Ramo-Tello, Cristina, Solaro, Claudio, Gobbi, Claudio, Cabrera-Gomez, Jose Antonio, Roullet, Etienne, Zwanikken, Cees, Den braber-Moerland, Leontien, Deri, Norma, Saladino, Maria Laura, Cristiano, Edgardo, Rojas, Juan Ignacio, Vrech, Carlos, Shaw, Cameron, Shuey, Neil, Boggild, Mike, Tan, Ik Lin, Hardy, Todd, Decoo, Danny, Moore, Fraser, Oh, Jiwon, Lalive, Patrice, Ampapa, Radek, Petersen, Thor, Oreja-Guevara, Celia, Perez Sempere, Angel, Dominguez, Jose Andres, Besora, Sarah, Hughes, Stella, Gray, Orla, Grigoriadis, Nikolaos, Piroska, Imre, Rozsa, Csilla, Kasa, Krisztian, Simo, Magdolna, Kovacs, Krisztina, Sas, Attila, Dobos, Eniko, Rajda, Cecilia, McGuigan, Chris, Mason, Deborah, Schepel, Jan, Alkhaboori, Jabir, Rio, Maria Edite, Mihaela, Simu, Al-Harbi, Talal, Altintas, Ayse, Kister, Ilya, Marriott, Mark, Kilpatrick, Trevor, King, John, Nguyen, Ai-Lan, Dwyer, Chris, Monif, Mastura, Taylor, Lisa, Diamanti, Matteo, Chisari, Clara, Toscano, Simona, Salvatore, Lo Fermo, Larochelle, Catherine, De Luca, Giovanna, Di Tommaso, Valeria, Travaglini, Daniela, Pietrolongo, Erika, di Ioia, Maria, Farina, Deborah, Mancinelli, Luca, Hupperts, Raymond, Olascoaga, Javier, Saiz, Albert, Zivadinov, Robert, Benedict, Ralph, Verheul, Freek, Fabis-Pedrini, Marzena, Mrabet, Saloua, Garber, Justin, Sanchez-Menoyo, Jose Luis, Aguera-Morales, Eduardo, Blanco, Yolanda, Al-Asmi, Abdullah, Weinstock-Guttman, Bianca, Fragoso, Yara, de Gans, Koen, and Kermode, Allan
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Human medicine - Abstract
you are agreeing to our Cookie Policy | Continue JAMA Network HomeJAMA Neurology This Issue Views 2,357 Citations 0 60 Full Text Share Comment Original Investigation May 15, 2023 Comparative Effectiveness of Autologous Hematopoietic Stem Cell Transplant vs Fingolimod, Natalizumab, and Ocrelizumab in Highly Active Relapsing-Remitting Multiple Sclerosis Tomas Kalincik, MD, PhD1,2; Sifat Sharmin, PhD1,2; Izanne Roos, MBChB, PhD1,2; Mark S. Freedman, MD3; Harold Atkins, MD4; Joachim Burman, MD, PhD5; Jennifer Massey, MBBS, PhD6,7; Ian Sutton, MBBS, PhD6,8; Barbara Withers, MD, PhD7,9; Richard Macdonell, MD, PhD10,11; Andrew Grigg, MD, PhD11,12; Øivind Torkildsen, MD, PhD13; Lars Bo, MD, PhD13; Anne Kristine Lehmann, MD, PhD14; Eva Kubala Havrdova, MD, PhD15; Eva Krasulova, MD, PhD15; Marek Trněný, MD, PhD16; Tomas Kozak, MD, PhD17; Anneke van der Walt, MBBS, PhD18,19; Helmut Butzkueven, MBBS, PhD18,19; Pamela McCombe, MBBS20,21; Olga Skibina, MBBS18,22,23; Jeannette Lechner-Scott, MD, PhD24,25; Barbara Willekens, MD, PhD26,27; Elisabetta Cartechini, MD28; Serkan Ozakbas, MD29; Raed Alroughani, MD30; Jens Kuhle, MD, PhD31; Francesco Patti, MD32,33; Pierre Duquette, MD34; Alessandra Lugaresi, MD, PhD35,36; Samia J. Khoury, MD, PhD37; Mark Slee, MD, PhD38; Recai Turkoglu, MD39; Suzanne Hodgkinson, MD40; Nevin John, MD, PhD41,42; Davide Maimone, MD43; Maria Jose Sa, MD44; Vincent van Pesch, MD, PhD45,46; Oliver Gerlach, MD, PhD47,48; Guy Laureys, MD49; Liesbeth Van Hijfte, MD49; Rana Karabudak, MD50; Daniele Spitaleri, MD51; Tunde Csepany, MD, PhD52; Riadh Gouider, MD53,54; Tamara Castillo-Triviño, MD55; Bruce Taylor, MD, PhD56,57; Basil Sharrack, MD, PhD58; John A. Snowden, MD, PhD59; and the MSBase Study Group Collaborators; and the MSBase Study Group Authors Author Affiliations JAMA Neurol. 2023;80(7):702-713. doi:10.1001/jamaneurol.2023.1184 editorial comment iconEditorial Comment Key Points Question What is the comparative effectiveness of autologous hematopoietic stem cell transplant (AHSCT) vs individual most potent disease-modifying therapies for relapsing-remitting multiple sclerosis (MS), such as natalizumab or ocrelizumab? Findings In this observational comparative effectiveness study of 4915 individuals using a composite cohort from specialized MS centers and the MSBase international registry, the effectiveness of AHSCT was compared with 1 medium-efficacy and 2 high-efficacy disease-modifying therapies (fingolimod, natalizumab, and ocrelizumab) in patients with relapsing-remitting MS, high frequency of relapses, and moderate disability. Over 5 years, AHSCT was associated with substantially lower relapse rate than fingolimod and marginally lower relapse rate than natalizumab and was also associated with a higher rate of recovery from disability compared with fingolimod and natalizumab, but no evidence of difference in clinical outcomes between AHSCT and ocrelizumab was found at 3-year follow-up. Meaning The results indicate that in relapsing-remitting MS, the clinical effectiveness of AHSCT is considerably superior to fingolimod and marginally superior to natalizumab. Abstract Importance Autologous hematopoietic stem cell transplant (AHSCT) is available for treatment of highly active multiple sclerosis (MS). Objective To compare the effectiveness of AHSCT vs fingolimod, natalizumab, and ocrelizumab in relapsing-remitting MS by emulating pairwise trials. Design, Setting, and Participants This comparative treatment effectiveness study included 6 specialist MS centers with AHSCT programs and international MSBase registry between 2006 and 2021. The study included patients with relapsing-remitting MS treated with AHSCT, fingolimod, natalizumab, or ocrelizumab with 2 or more years study follow-up including 2 or more disability assessments. Patients were matched on a propensity score derived from clinical and demographic characteristics. Exposure AHSCT vs fingolimod, natalizumab, or ocrelizumab. Main outcomes Pairwise-censored groups were compared on annualized relapse rates (ARR) and freedom from relapses and 6-month confirmed Expanded Disability Status Scale (EDSS) score worsening and improvement. Results Of 4915 individuals, 167 were treated with AHSCT; 2558, fingolimod; 1490, natalizumab; and 700, ocrelizumab. The prematch AHSCT cohort was younger and with greater disability than the fingolimod, natalizumab, and ocrelizumab cohorts; the matched groups were closely aligned. The proportion of women ranged from 65% to 70%, and the mean (SD) age ranged from 35.3 (9.4) to 37.1 (10.6) years. The mean (SD) disease duration ranged from 7.9 (5.6) to 8.7 (5.4) years, EDSS score ranged from 3.5 (1.6) to 3.9 (1.9), and frequency of relapses ranged from 0.77 (0.94) to 0.86 (0.89) in the preceding year. Compared with the fingolimod group (769 [30.0%]), AHSCT (144 [86.2%]) was associated with fewer relapses (ARR: mean [SD], 0.09 [0.30] vs 0.20 [0.44]), similar risk of disability worsening (hazard ratio [HR], 1.70; 95% CI, 0.91-3.17), and higher chance of disability improvement (HR, 2.70; 95% CI, 1.71-4.26) over 5 years. Compared with natalizumab (730 [49.0%]), AHSCT (146 [87.4%]) was associated with marginally lower ARR (mean [SD], 0.08 [0.31] vs 0.10 [0.34]), similar risk of disability worsening (HR, 1.06; 95% CI, 0.54-2.09), and higher chance of disability improvement (HR, 2.68; 95% CI, 1.72-4.18) over 5 years. AHSCT (110 [65.9%]) and ocrelizumab (343 [49.0%]) were associated with similar ARR (mean [SD], 0.09 [0.34] vs 0.06 [0.32]), disability worsening (HR, 1.77; 95% CI, 0.61-5.08), and disability improvement (HR, 1.37; 95% CI, 0.66-2.82) over 3 years. AHSCT-related mortality occurred in 1 of 159 patients (0.6%). Conclusion In this study, the association of AHSCT with preventing relapses and facilitating recovery from disability was considerably superior to fingolimod and marginally superior to natalizumab. This study did not find evidence for difference in the effectiveness of AHSCT and ocrelizumab over a shorter available follow-up time.
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39. sj-docx-2-mso-10.1177_20552173231154712 - Supplemental material for Achieving no evidence of disease activity-3 in highly active multiple sclerosis patients treated with cladribine and monoclonal antibodies
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Alonso, Ricardo, Casas, Magdalena, Lazaro, Luciana, Fernandez Liguori, Nora, Pita, Cecilia, Cohen, Leila, Rojas, Juan Ignacio, Pappolla, Agustín, Patrucco, Liliana, Cristiano, Edgardo, Burgos, Marcos, Vrech, Carlos, Piedrabuena, Raul, Pablo, Lopez, Deri, Norma, Luetic, Geraldine, Miguez, Jimena, Cabrera, Mariela, Martinez, Alejandra, Zanga, Gisela, Tkachuk, Verónica, Tizio, Santiago, Carnero Contentti, Edgar, Knorre, Eduardo, Leguizamon, Felisa, Mainella, Carolina, Nofal, Pedro, Liwacki, Susana, Hryb, Javier, Menichini, Maria, Pestchanker, Claudia, Alonso, Marina, Garcea, Orlando, and Silva, Berenice
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FOS: Clinical medicine ,110904 Neurology and Neuromuscular Diseases ,Neuroscience - Abstract
Supplemental material, sj-docx-2-mso-10.1177_20552173231154712 for Achieving no evidence of disease activity-3 in highly active multiple sclerosis patients treated with cladribine and monoclonal antibodies by Ricardo Alonso, Magdalena Casas, Luciana Lazaro, Nora Fernandez Liguori, Cecilia Pita, Leila Cohen, Juan Ignacio Rojas, Agustín Pappolla, Liliana Patrucco, Edgardo Cristiano, Marcos Burgos, Carlos Vrech, Raul Piedrabuena, Lopez Pablo, Norma Deri, Geraldine Luetic, Jimena Miguez, Mariela Cabrera, Alejandra Martinez, Gisela Zanga, Verónica Tkachuk, Santiago Tizio, Edgar Carnero Contentti, Eduardo Knorre, Felisa Leguizamon, Carolina Mainella, Pedro Nofal, Susana Liwacki, Javier Hryb, Maria Menichini, Claudia Pestchanker, Marina Alonso, Orlando Garcea and Berenice Silva in Multiple Sclerosis Journal – Experimental, Translational and Clinical
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- 2023
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40. sj-docx-3-mso-10.1177_20552173231154712 - Supplemental material for Achieving no evidence of disease activity-3 in highly active multiple sclerosis patients treated with cladribine and monoclonal antibodies
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Alonso, Ricardo, Casas, Magdalena, Lazaro, Luciana, Fernandez Liguori, Nora, Pita, Cecilia, Cohen, Leila, Rojas, Juan Ignacio, Pappolla, Agustín, Patrucco, Liliana, Cristiano, Edgardo, Burgos, Marcos, Vrech, Carlos, Piedrabuena, Raul, Pablo, Lopez, Deri, Norma, Luetic, Geraldine, Miguez, Jimena, Cabrera, Mariela, Martinez, Alejandra, Zanga, Gisela, Tkachuk, Verónica, Tizio, Santiago, Carnero Contentti, Edgar, Knorre, Eduardo, Leguizamon, Felisa, Mainella, Carolina, Nofal, Pedro, Liwacki, Susana, Hryb, Javier, Menichini, Maria, Pestchanker, Claudia, Alonso, Marina, Garcea, Orlando, and Silva, Berenice
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FOS: Clinical medicine ,110904 Neurology and Neuromuscular Diseases ,Neuroscience - Abstract
Supplemental material, sj-docx-3-mso-10.1177_20552173231154712 for Achieving no evidence of disease activity-3 in highly active multiple sclerosis patients treated with cladribine and monoclonal antibodies by Ricardo Alonso, Magdalena Casas, Luciana Lazaro, Nora Fernandez Liguori, Cecilia Pita, Leila Cohen, Juan Ignacio Rojas, Agustín Pappolla, Liliana Patrucco, Edgardo Cristiano, Marcos Burgos, Carlos Vrech, Raul Piedrabuena, Lopez Pablo, Norma Deri, Geraldine Luetic, Jimena Miguez, Mariela Cabrera, Alejandra Martinez, Gisela Zanga, Verónica Tkachuk, Santiago Tizio, Edgar Carnero Contentti, Eduardo Knorre, Felisa Leguizamon, Carolina Mainella, Pedro Nofal, Susana Liwacki, Javier Hryb, Maria Menichini, Claudia Pestchanker, Marina Alonso, Orlando Garcea and Berenice Silva in Multiple Sclerosis Journal – Experimental, Translational and Clinical
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- 2023
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41. sj-docx-1-mso-10.1177_20552173231154712 - Supplemental material for Achieving no evidence of disease activity-3 in highly active multiple sclerosis patients treated with cladribine and monoclonal antibodies
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Alonso, Ricardo, Casas, Magdalena, Lazaro, Luciana, Fernandez Liguori, Nora, Pita, Cecilia, Cohen, Leila, Rojas, Juan Ignacio, Pappolla, Agustín, Patrucco, Liliana, Cristiano, Edgardo, Burgos, Marcos, Vrech, Carlos, Piedrabuena, Raul, Pablo, Lopez, Deri, Norma, Luetic, Geraldine, Miguez, Jimena, Cabrera, Mariela, Martinez, Alejandra, Zanga, Gisela, Tkachuk, Verónica, Tizio, Santiago, Carnero Contentti, Edgar, Knorre, Eduardo, Leguizamon, Felisa, Mainella, Carolina, Nofal, Pedro, Liwacki, Susana, Hryb, Javier, Menichini, Maria, Pestchanker, Claudia, Alonso, Marina, Garcea, Orlando, and Silva, Berenice
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FOS: Clinical medicine ,110904 Neurology and Neuromuscular Diseases ,Neuroscience - Abstract
Supplemental material, sj-docx-1-mso-10.1177_20552173231154712 for Achieving no evidence of disease activity-3 in highly active multiple sclerosis patients treated with cladribine and monoclonal antibodies by Ricardo Alonso, Magdalena Casas, Luciana Lazaro, Nora Fernandez Liguori, Cecilia Pita, Leila Cohen, Juan Ignacio Rojas, Agustín Pappolla, Liliana Patrucco, Edgardo Cristiano, Marcos Burgos, Carlos Vrech, Raul Piedrabuena, Lopez Pablo, Norma Deri, Geraldine Luetic, Jimena Miguez, Mariela Cabrera, Alejandra Martinez, Gisela Zanga, Verónica Tkachuk, Santiago Tizio, Edgar Carnero Contentti, Eduardo Knorre, Felisa Leguizamon, Carolina Mainella, Pedro Nofal, Susana Liwacki, Javier Hryb, Maria Menichini, Claudia Pestchanker, Marina Alonso, Orlando Garcea and Berenice Silva in Multiple Sclerosis Journal – Experimental, Translational and Clinical
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- 2023
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42. The risk of secondary progressive multiple sclerosis is geographically determined but modifiable
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Sharmin, Sifat, Roos, Izanne, Simpson-Yap, Steve, Malpas, Charles, Sánchez, Marina M, Ozakbas, Serkan, Horakova, Dana, Havrdova, Eva K, Patti, Francesco, Alroughani, Raed, Izquierdo, Guillermo, Eichau, Sara, Boz, Cavit, Zakaria, Magd, Onofrj, Marco, Lugaresi, Alessandra, Weinstock-Guttman, Bianca, Prat, Alexandre, Girard, Marc, Duquette, Pierre, Terzi, Murat, Amato, Maria Pia, Karabudak, Rana, Grand'Maison, Francois, Khoury, Samia J, Grammond, Pierre, Lechner-Scott, Jeannette, Buzzard, Katherine, Skibina, Olga, van der Walt, Anneke, Butzkueven, Helmut, Turkoglu, Recai, Altintas, Ayse, Maimone, Davide, Kermode, Allan, Shalaby, Nevin, Pesch, Vincent V, Butler, Ernest, Sidhom, Youssef, Gouider, Riadh, Mrabet, Saloua, Gerlach, Oliver, Soysal, Aysun, Barnett, Michael, Kuhle, Jens, Hughes, Stella, Maria J, Sa, Hodgkinson, Suzanne, Oreja-Guevara, Celia, Ampapa, Radek, Petersen, Thor, Ramo-Tello, Cristina, Spitaleri, Daniele, Mccombe, Pamela, Taylor, Bruce, Prevost, Julie, Foschi, Matteo, Slee, Mark, Mcguigan, Chris, Laureys, Guy, Hijfte, Liesbeth V, de Gans, Koen, Solaro, Claudio, Jiwon, Oh, Macdonell, Richard, Aguera-Morales, Eduardo, Singhal, Bhim, Gray, Orla, Garber, Justin, Wijmeersch, Bart V, Simu, Mihaela, Triviño, Tamara C, Sanchez-Menoyo, Jose L, Khurana, Dheeraj, Al-Asmi, Abdullah, Al-Harbi, Talal, Deri, Norma, Fragoso, Yara, Lalive, Patrice H, Sinnige, L G F, Shaw, Cameron, Shuey, Neil, Csepany, Tunde, Sempere, Angel P, Moore, Fraser, Decoo, Danny, Willekens, Barbara, Gobbi, Claudio, Massey, Jennifer, Hardy, Todd, Parratt, John, and Kalincik, Tomas
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secondary progressive multiple sclerosis ,health expenditure ,disease-modifying therapy ,geography ,latitude - Published
- 2023
43. Disease activity after discontinuation of disease-modifying therapies in patients with multiple sclerosis in Argentina: data from the nationwide registry RelevarEM
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Zanga, Gisela, Portinari, Carla, Barber, Josefina, Ibañez, Tomas, Brolese, Lucia, Agustín, Pappolla, Jimena, Miguez, Liliana, Patrucco, Edgardo, Cristiano, Deri, Norma, Tkachuk, Verónica, Vrech, Carlos, Cohen, Leila, Ricardo, Alonso, Orlando, Garcea, Berenice, Silva, Ysrraelit, Celica, Mariano, Marrodan, María I, Gaitán, Jorge, Correale, Burgos, Marcos, Lázaro, Luciana, Chertcoff, Anibal, Silva, Emanuel, Knorre, Eduardo, Steinberg, Judith, Tavolini, Dario, Hryb, Javier, Nofal, Pedro, Leguizamon, Felisa, Lopez A, Pablo, Liwacki, Susana, Blaya, Patricio, Piedrabuena, Raul, Carra, Adriana, Martinez, Alejandra, Balbuena, María Eugenia, Carnero, Contentti Edgar, Alves Pinheiro, Amelia, Mainella, Carolina, Coppola, Mariano, Recchia, Luciano, Kohler, Matias, Kohler, Eduardo, Curbelo, María Celeste, Menichini, Maria Laura, Tizio, Santiago, Cabrera, Mariela, Pagani Cassará, Fatima, Barboza, Andres, Luetic, Geraldine, Marina, Alonso Serena, Rojas, Juan Ignacio, and Sorbara, Marcos
- Abstract
The discontinuation of disease-modifying therapies (DMTs) in multiple sclerosis (MS) is commonly seen in real-world settings due to several factors.The aim of this study is to describe the frequency of disease activity after discontinuation of DMTs in MS patients included in the Argentinean MS and NMOSD registry.Patients with relapsing remitting MS (RRMS) and active secondary progressive MS (SPMS) were included based on the following criteria: they discontinued treatment for more than 6 months, they had been treated with a DMT for ≥2 years, and they had at least 6 months of follow-up in the registry after discontinuation. Demographic and clinical data were collected. Disease activity during follow-up was defined as the presence of a clinical relapse or a new magnetic resonance (MRI) lesion (either new lesions on T2-weighted sequence and/or contrast enhancement). Bivariate analysis was applied to identify clinical and demographic factors related to disease activity.We included 377 patients (75.5% RRMS, 22.5% SPMS) who had discontinued DMTs. The mean (SD) follow-up after discontinuation was 15.7 (7.9) months. After discontinuation, the presence of relapse was detected in 18.8% and 3.5% in RRMS and SPMS, respectively; and new MRI activity in 22% and 3.5%, respectively. We found that higher risk of relapse and MRI activity was associated with younger age (p 0.001), shorter disease duration (p 0.001), and RRMS phenotype (p = 0.006). Males showed higher MRI activity (p 0.011). This study provides real-world data that can guide physicians when considering discontinuation of DMTs.
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- 2022
44. Frequency of new asymptomatic MRI lesions during attacks and follow-up of patients with NMOSD in a real-world setting.
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Carnero Contentti, Edgar, Lopez, Pablo A, Tkachuk, Verónica, Vrech, Carlos, Zarate, María A, Correale, Jorge, Deri, Norma, Luetic, Geraldine, Marrodan, Mariano, Pagani Cassara, Fátima, Tavolini, Darío, Ysrraelit, María Célica, Balbuena, María E, Hryb, Javier, Chiganer, Edson, Leguizamon, Felisa, Knorre, Eduardo, Zanga, Gisela, Pestchanker, Claudia, and Barboza, Andrés
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NEUROMYELITIS optica ,MAGNETIC resonance imaging ,OPTIC nerve injuries - Abstract
Background: We aimed to assess the frequency of new asymptomatic lesions on brain and spinal imaging (magnetic resonance imaging (MRI)) and their association with subsequent relapses in a large cohort of neuromyelitis optica spectrum disorder (NMOSD) patients in Argentina. Methods: We retrospectively reviewed 675 MRI (225 performed during an attack and 450 during the relapse-free period (performed at least 3 months from the last attack)) of NMOSD patients who had at least 2 years of clinical and MRI follow-up since disease onset. Kaplan–Meier (KM) curves were used for depicting time from remission MRI to subsequent relapse. Results: We included 135 NMOSD patients (64.4% were aquaporin-4-immunoglobulin G (AQP4-IgG)-positive). We found that 26 (19.26%) and 66 (48.88%) of patients experienced at least one new asymptomatic MRI lesion during both the relapse-free period and attacks, respectively. The most frequent asymptomatic MRI lesions were optic nerves followed by short-segment myelitis during the relapse-free period and attacks. KM curves did not show differences in the time taken to develop a new relapse. Conclusion: Our findings showed that new asymptomatic lesions are relatively frequent. However, the presence of new asymptomatic MRI lesions during the relapse-free period and at relapses was not associated with a shorter time to developing subsequent relapses. [ABSTRACT FROM AUTHOR]
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- 2023
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45. Disability outcomes in NMOSD and MOGAD patients: data from a nationwide registry in Argentina
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Rojas, Juan I., primary, Pappolla, Agustín, additional, Patrucco, Liliana, additional, Cristiano, Edgardo, additional, Miguez, Jimena, additional, Liwacki, Susana, additional, Tkachuk, Verónica, additional, Balbuena, María E., additional, Vrech, Carlos, additional, Deri, Norma, additional, Correale, Jorge, additional, Marrodan, Mariano, additional, Ysrraelit, María C., additional, Fiol, Marcela, additional, Leguizamon, Felisa, additional, Luetic, Geraldine, additional, Menichini, María L., additional, Lopez, Pablo A., additional, Pettinicchi, Juan Pablo, additional, Criniti, Juan, additional, Caride, Alejandro, additional, Tavolini, Darío, additional, Mainella, Carolina, additional, Zanga, Gisela, additional, Burgos, Marcos, additional, Hryb, Javier, additional, Barboza, Andrés, additional, Lazaro, Luciana, additional, Alonso, Ricardo, additional, Silva, Berenice, additional, Fernández Liguori, Nora, additional, Nadur, Débora, additional, Chercoff, Aníbal, additional, Martinez, Alejandra, additional, Steinberg, Judith, additional, Garcea, Orlando, additional, Carrá, Adriana, additional, Alonso Serena, Marina, additional, and Carnero Contentti, Edgar, additional
- Published
- 2022
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46. Machine-learning-based prediction of disability progression in multiple sclerosis: an observational, international, multi-center study
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De Brouwer, Edward, primary, Becker, Thijs, additional, Werthen-Brabants, Lorin, additional, Dewulf, Pieter, additional, Iliadis, Dimitrios, additional, Dekeyser, Cathérine, additional, Laureys, Guy, additional, Van Wijmeersch, Bart, additional, Popescu, Veronica, additional, Dhaene, Tom, additional, Deschrijver, Dirk, additional, Waegeman, Willem, additional, De Baets, Bernard, additional, Stock, Michiel, additional, Horakova, Dana, additional, Patti, Francesco, additional, Izquierdo, Guillermo, additional, Eichau, Sara, additional, Girard, Marc, additional, Prat, Alexandre, additional, Lugaresi, Alessandra, additional, Grammond, Pierre, additional, Kalincik, Tomas, additional, Alroughani, Raed, additional, Grand’Maison, Francois, additional, Skibina, Olga, additional, Terzi, Murat, additional, Lechner-Scott, Jeannette, additional, Gerlach, Oliver, additional, Khoury, Samia J., additional, Cartechini, Elisabetta, additional, Van Pesch, Vincent, additional, Sa, Maria Jose, additional, Weinstock-Guttman, Bianca, additional, Blanco, Yolanda, additional, Ampapa, Radek, additional, Spitaleri, Daniele, additional, Solaro, Claudio, additional, Maimone, Davide, additional, Soysal, Aysun, additional, Iuliano, Gerardo, additional, Gouider, Riadh, additional, Castillo-Triviño, Tamara, additional, Sanchez-Menoyo, Jose Luis, additional, van der Walt, Anneke, additional, Oh, Jiwon, additional, Aguera-Morales, Eduardo, additional, Altintas, Ayse, additional, Al-Asmi, Abdullah, additional, de Gans, Koen, additional, Fragoso, Yara, additional, Csepany, Tunde, additional, Hodgkinson, Suzanne, additional, Deri, Norma, additional, Al-Harbi, Talal, additional, Taylor, Bruce, additional, Gray, Orla, additional, Lalive, Patrice, additional, Rozsa, Csilla, additional, McGuigan, Chris, additional, Kermode, Allan, additional, Perez sempere, Angel, additional, Mihaela, Simu, additional, Simo, Magdolna, additional, Hardy, Todd, additional, Decoo, Danny, additional, Hughes, Stella, additional, Grigoriadis, Nikolaos, additional, Sas, Attila, additional, Vella, Norbert, additional, Moreau, Yves, additional, and Peeters, Liesbet, additional
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- 2022
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47. Preferences for Disease-Modifying Therapies in Argentina: Cross-Sectional Conjoint Analysis of Patients and Neurologists
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Rojas, Juan I., primary, Patrucco, Liliana, additional, Alonso, Ricardo, additional, Lopez, Pablo A., additional, Deri, Norma, additional, Pettinicchi, Juan Pablo, additional, Cristiano, Edgardo, additional, and Carnero Contentti, Edgar, additional
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- 2022
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48. Highly active immunomodulatory therapy ameliorates accumulation of disability in moderately advanced and advanced multiple sclerosis
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Lizak, Nathaniel, Lugaresi, Alessandra, Alroughani, Raed, Lechner-Scott, Jeannette, Slee, Mark, Havrdova, Eva, Horakova, Dana, Trojano, Maria, Izquierdo, Guillermo, Duquette, Pierre, Girard, Marc, Prat, Alexandre, Grammond, Pierre, Hupperts, Raymond, GrandʼMaison, Francois, Sola, Patrizia, Pucci, Eugenio, Bergamaschi, Roberto, Oreja-Guevara, Celia, Van Pesch, Vincent, Ramo, Cristina, Spitaleri, Daniele, Iuliano, Gerardo, Boz, Cavit, Granella, Franco, Olascoaga, Javier, Verheul, Freek, Rozsa, Csilla, Cristiano, Edgardo, Flechter, Shlomo, Hodgkinson, Suzanne, Amato, Maria Pia, Deri, Norma, Jokubaitis, Vilija, Spelman, Tim, Butzkueven, Helmut, and Kalincik, Tomas
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- 2017
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49. SEROLOGICAL RESPONSE TO SARS-COV-2 VACCINES IN PATIENTS WITH MULTIPLE SCLEROSIS IN ARGENTINA.
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ROJAS, JUAN I., ALONSO, RICARDO, CABRERA, MARIELA, CONTENTTI, EDGAR CARNERO, CRISTIANO, EDGARDO, DERI, NORMA, HRYB, JAVIER, LOPEZ, PABLO, LUETIC, GERALDINE, PATRUCCO, LILIANA, TKACHUK, VERONICA, YSRRAELIT, MARÍA C., ZANGA, GISELA, CRUCES, LEONEL, TURK, GABRIELA, LONGUEIRA, YESICA, LAUFER, NATALIA, and NUÑEZ, SEBASTIAN
- Abstract
Introduction: The objective was to assess the immunogenicity and effectiveness of vaccines against SARSCoV-2 in multiple sclerosis (MS) patients included in the Argentinean MS registry. Methods: A prospective cohort study between May and December 2021. The primary outcome was immunogenicity and effectiveness of vaccines during a three-month follow-up. Immunogenicity was evaluated based on detection of total antibodies (Ab) against spike protein and neutralizing Ab in serum 4 weeks after the second vaccine dose. A positive COVID-19 case was defined according to Argentinean Ministry of Health. Results: 94 patients were included, mean age: 41.7 ± 12.1 years. Eighty (85.1%) had relapsing remitting multiple sclerosis (RRMS); 30 (31.9%) were under fingolimod treatment. The Sputnik V vaccine was the first dose in 33 (35.1%), and AstraZeneca in 61 (64.9%). In 60 (63.8%), the vaccine elicited a specific humoral response. Immunological response according to the vaccination schemes showed no qualitative differences (p = 0.45). Stratified analysis according to the MS treatment showed that a significantly smaller number of subjects developed antibodies against spike antigen among those that were on ocrelizumab compared to other groups (p ≤ 0.001), while a reduced number of patients under ocrelizumab where evaluated (n = 7). This was also observed for neutralizing antibodies in the ocrelizumab group (p < 0.001). During the three-month follow-up, two individuals were diagnosed with COVID-19. Conclusion: We found that MS patients that received Sputnik V or AstraZeneca vaccines for SARS-CoV-2 developed a serological response with no differences between the vaccines used. [ABSTRACT FROM AUTHOR]
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- 2023
50. Clinical and demographic characteristics of primary progressive multiple sclerosis in Argentina: Argentinean registry cohort study (RelevarEM)
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Lázaro Luciana, Eizaguirre Bárbara, Saladino María Laura, Hryb Javier, Tkachuk Verónica, Alves Pinheiro Amelia, Cohen Leila, Luetic Geraldine, Silva Emanuel, Agustín Pappolla, Deri Norma, Vrech Carlos, Barboza Andres, Carra Adriana, Balbuena María Eugenia, López Pablo, Carnero Contentti Edgar, RelevarEM investigators, Pita Cecilia, Garcea Orlando, Fernández Liguori Nora, Quarracino Cecilia, Alonso Ricardo, Divi Pablo, Menichini María Laura, Edgardo Cristiano, Zanga Gisela, Silva Berenice, Liliana Patrucco, Steinberg Judith, Jimena Miguez, Tavolini Dario, Rojas Juan Ignacio, and Volman Gabriel
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medicine.medical_specialty ,Pediatrics ,Neurology ,Expanded Disability Status Scale ,business.industry ,Multiple sclerosis ,Dermatology ,General Medicine ,medicine.disease ,03 medical and health sciences ,Psychiatry and Mental health ,0302 clinical medicine ,Epidemiology ,medicine ,Ocrelizumab ,030212 general & internal medicine ,Neurology (clinical) ,Neurosurgery ,business ,030217 neurology & neurosurgery ,Neuroradiology ,Cohort study ,medicine.drug - Abstract
Primary progressive multiple sclerosis (PPMS) is an infrequent clinical form of multiple sclerosis (MS). Scarce information is available about PPMS in Latin America. The aim of this work is to describe the clinical and demographic characteristics of PPMS patients in Argentina. RelevarEM is a longitudinal, strictly observational registry in Argentina. Clinical and epidemiological data from PPMS patients were described. There were 144 cases of PPMS. They represented 7% of MS patients. The mean age was 44.1 years. The female:male ratio was 1.08. The mean Expanded Disability Status Scale (EDSS) score was 5.5 and the mean disease evolution time was 10.6 years. Oligoclonal bands were found in 72.9%. At the time of diagnosis, magnetic resonance imaging showed spinal cord lesions in 82.6% and contrast-enhancing brain lesions in 18.1% of patients. Almost one third of patients were treated with a disease-modifying drug, and ocrelizumab was the most frequently used (55.8%). PPMS is an infrequent subtype of MS and its recognition is of the highest importance as it has its own evolution, treatment, and prognosis. The importance of our research resides in providing local data and contributing to a better understanding of PPMS and its treatment in Latin America.
- Published
- 2020
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