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Australia’s approach to managing and conserving its offshore islands as important national assets warrants urgent review. There is a growing realisation that the current trajectory of loss of natural heritage on islands must be reversed, particularly in an era of increasing climate change. We propose a role description and an organisational model for a national Australian Islands Alliance that champions conservation action, prioritises investments aligned to risks, and that connects partners at a strategic national level. A national alliance offers important opportunity to assess threats and report on condition. Four key foundations underpin a national alliance dedicated to championing island care and expert management: (1) management informed by evidence; (2) sound return on investment; (3) national coordination in partnership with States and Territories; and (4) community participation inclusive of Aboriginal peoples’ and Torres Strait Islanders’ custodial rights and interests. The message from experiences shared across Australia, New Zealand and the Pacific region is that traditional island custodians and stakeholders are vital partners to restoration efforts. These shared learnings collectively demonstrate the time is now for Australia to move forward with a respectful and unified direction to progress successful and sustainable island conservation and restoration.

Conservation entrepreneurship is based on the notion that it is possible to build a business system around a conservation challenge, and in doing so, create a targeted and adequate resourcing mechanism to support interventions, over adequate time frames. Constructing business models is not something that is usually at the forefront of a conservation practitioner’s agenda, nor often within their capacity. This paper takes the reader through the process of building such models, within the context of offshore islands in the Australian region, and using structures and terminologies that are commonplace in the business world, but perhaps not so much so in the conservation sector. In addition, this business model approach is presented in context of the ‘collective impact’ framework, which involves centralised infrastructure, dedicated management, and a structure ensuring development of a common agenda, shared measurement systems (i.e. of what success looks like), continuous communication, and mutually reinforcing activities amongst all those involved.

Context Island landscapes and component biodiversity provide invaluable services. However, these are threatened by climate change. There is currently no framework for assessing and mitigating such threats on islands. Aims Based on an existing adaptation standard, we aimed to propose a systematic approach for planning the adaptation of islands based on a risk management process. Methods For each risk, we investigated a range of adaptation approaches that can be considered and selected by conservation practitioners in designing conservation interventions. Key results For each risk identified, a range of adaptation measures can be selected: do nothing; maintain and enhance habitat, intensive species management, and preserve populations (including through ex situ conservation); or exploit the natural characteristics of islands to conserve biodiversity. Conclusions This approach provides a decision-making matrix of risks/drivers vs adaptation measures to assist in the design of conservation interventions, which can be applied to Australian islands on a priority basis. Implications There will inevitably remain gaps in knowledge and understanding that will hamper conservation efforts. There will also remain circumstances where adaptation is not possible and loss of services and biodiversity will follow as a result of climate change. However, the proposed model for assessing and adapting to climate change risks is a step forward from the current situation, where relatively little consideration is being given to climate change when developing island conservation interventions.

Open access funding provided by Umea University. The purpose of this paper is to present and discuss a puzzle involving accommodation. The puzzle is based on three assumptions. The first assumption is that accommodation takes place after an utterance. The second assumption is that accommodation can make a difference to the truth-value of an utterance even if the utterance is not about the future. The third assumption is that something that takes place after an utterance cannot make a difference to the truth-value of the utterance unless the utterance is about the future. Since these assumptions are jointly inconsistent, one of them must be false. The question is which one we ought to reject. The majority of the discussion is devoted to discussing each of the options, and the tentative conclusion is that the most plausible strategy is to reject the third thesis. That amounts to saying that something that takes place after an utterance can make a difference to the truth-value of the utterance even if the utterance is not about the future. Publisher PDF

Australia needs a new shared vision that the current trajectory of loss of natural heritage on its offshore islands is not acceptable and needs to change. This Special Issue brings together seven papers from leaders and practitioners with experience in offshore islands across the Australian and New Zealand context. The fundamentals for each paper are to suggest potential solutions or scenarios to move forward with island policy, and management.

To investigate how initial fitness, maturity status, and training time explain changes in physical performance across one season. Eighty-eight adolescent male footballers, representing four age categories (Under 15 [n = 12], Under 14 [n = 21], Under 13 [n = 25], Under 12 [n = 30]), were tested using physical performance tests (20 m sprint, change of direction, squat jump and yo-yo intermittent recovery test level 1 [YYIRTL1]) and maturity offset at the season start (Test 1) and end (Test 2). Multiple regression determined the proportion of variance in test score changes, explained by three predictor variables: initial fitness (i.e., Test 1), maturity offset change, and training time. With combined categories, predictor variables explained 0.051 to 0.297 of the variance in physical performance score changes. Analysing age categories separately, predictor variables explained 0.047 to 0.407 (20 m sprint), 0.202 to 0.626 (change of direction), 0.336 to 0.502 (squat jump), and 0.196 to 0.777 (YYIRTL1) of variance in test score changes. Of the limited differences in relative predictor contribution, Test 1 was the strongest predictor of test score change. Initial fitness, maturity status change, and training time explain small and inconsistent proportions of variance in adolescent footballers’ physical development across one season.

One of the features of the novelist George Eliot that distinguished her from most other mid-Victorian novelists was that she was an excellent practising mathematician. Eliot, like Galileo, understood the power mathematics has to challenge established but unsubstantiated social and philosophical beliefs. Eliot’s inclusion in her novels, both of characters who do mathematics, and also of depictions of learning mathematics, is indicative of how mathematics influenced Eliot’s understanding of the world. Her logical approach to making sense of society is reflected in the way she uses mathematical language, mathematical images, and mathematical arguments in her novels, and particularly in the way she structures her novels and develops networks of relationships. Put succinctly, Eliot’s mathematics profoundly influenced the way she thought and wrote.

Contemporary relativists often see their view as contributing to a semantic/post-semantic account of linguistic data about disagreement and retraction. I offer an independently motivated metasemantic account of the same data, that also handles a number of cases and empirical results that are problematic for the relativist. The key idea is that the content of assertions and beliefs is determined in part by facts about other times, including times after the assertion is made or the belief is formed. On this temporal externalist view, speaker behaviours such as retraction of previous assertions play a role in making it the case that a past utterance has a given meaning. Postprint

This paper is an output of the project ‘Rethinking Mind and Meaning: A case study from a co-disciplinary approach’ (Award Nr.: AH/ L015234/1), funded by the Arts and Humanities Research Council (AHRC), as part of the Science in Culture Theme (http://www.sciculture.ac.uk). A core component of any folk physical understanding of the world is object individuation - the cognitive ability to parse sensory input into discrete objects. Whereas younger human infants use spatio-temporal information to individuate objects, they do not use property and kind information until one year of age. Some researchers propose that object individuation based on property/kind information depends on language acquisition and sortal concepts. However, there is evidence that preverbal infants and nonhuman animals also use both types of information. The present study aimed to further explore the evolutionary origins of object individuation by testing a new-world monkey species, capuchin monkeys (Sapajus spp.), using both manual search (n = 29) and looking time (n = 23) measures. In Spatio-temporal trials, subjects saw one or two objects dropped into a box, but always found (or saw) only one. In Property/kind trials, subjects saw either object A or B being dropped into a box and then always found (or saw) object A. The capuchin monkeys looked longer and searched more on inconsistent trials – with outcome differing in quantity or in kind - which suggested that they had expectations based on both spatio-temporal and property-kind representations. Looking time and search measures gave convergent results at the group but not at the individual level. Our results add to the existing evidence contradicting the linguistic hypothesis of property/kind individuation. However, contrary to recent discussions, we argue that these and related results can be explained without appealing to the notion of sortal concepts or multiple representational systems, and suggest that a full picture of the ontogeny and phylogeny of object individuation requires further empirical and theoretical research. Publisher PDF

The skeleton is recognised as a key endocrine regulator of metabolism. Here we show that mice lacking the bone mineralization enzyme PHOSPHO1 (Phospho1-/-) exhibited improved basal glucose homeostasis and resisted high-fat-diet induced weight gain and diabetes. The metabolic protection inPhospho1-/-mice was manifested in the absence of altered levels of osteocalcin. Osteoblasts isolated fromPhospho1-/-mice were enriched for genes associated with energy metabolism and diabetes;Phospho1both directly and indirectly interacted with genes associated with glucose transport and insulin receptor signalling. Canonical thermogenesis via brown adipose tissue did not underlie the metabolic protection observed in adultPhospho1-/-mice. However, the decreased serum choline levels inPhospho1-/-mice were normalized by feeding a 2% choline rich diet resulting in a normalization in insulin sensitivity and fat mass. This study identifies PHOSPHO1 as a potential therapeutic target for the treatment of obesity and diabetes.

The idea that experts (especially scientific experts) play a privileged role in determining the meanings of our words and the contents of our concepts has become commonplace since the work of Hilary Putnam, Tyler Burge, and others in the 1970s. But if experts have the power to determine what our words mean, they can do so responsibly or irresponsibly, from good motivations or bad, justly or unjustly, with good or bad effects. This paper distinguishes three families of metasemantic views based on their attitudes towards bad behaviour by meaning‐fixing experts, and draws a series of distinctions relevant for the normative evaluation of meaning‐determining actions. Postprint

New findings What is the central question of this review? Is exposure to a hot environment detrimental to neuromuscular performance? What is the main finding and what is its importance? Elevating body temperature improves peak power during short-duration, high-intensity exercise but trades off with an accelerated rate of decay. Higher muscle temperatures and cross-bridge cycling rate resemble a shift in contractile characteristic to a faster phenotype. Prolonged moderate-intensity exercise capacity is impaired in a hot environment. Fatigue appears to combine a reduced drive from the CNS and increased cardiovascular strain to maintain skeletal muscle perfusion and thermoregulation. Abstract The effect of thermal stress on human work capacity and neuromuscular function has been of interest to physiologists since the 19th century. The aim of the present review is to examine the impact of exposure to heat stress on neuromuscular performance. Exposure to heat stress during exercise is known to increase strain on the cardiovascular system owing to the competing demands of skeletal muscle perfusion and homeostatic thermoregulation. The effects of exposure to heat stress on the neuromuscular system are more complex, because in some circumstances an elevation in muscle temperature leads to an improvement in function, whereas in other circumstances an increase in temperature leads to a decrement in function that is a consequence of the mode, metabolic demand and duration of the exercise. The ability to sustain isometric tension is impaired with an elevated muscle temperature and so too is locomotor capacity over prolonged periods of time. In contrast, peak power production is enhanced by increasing muscle temperature but is achieved at the expense of maintaining power output, owing to a higher rate of decay in power production. The different effects on neuromuscular function at an elevated muscle temperature are explained, in part, by a higher rate of energy turnover. In addition, the effect of an elevated core temperature also appears to impair neuromuscular performance either owing to a reduced voluntary drive in motor unit recruitment or to a failure in muscle afferent feedback, or a combination of the two.

This chapter develops a conception of philosophical analysis which makes sense of the idea that a correct analysis can be revisionary (in that it departs from ordinary or expert belief and linguistic usage). The view is superior to the alternatives defended by most proponents of ‘conceptual ethics’ and ‘conceptual engineering’ (according to which revisionary theorizing involves replacing words or concepts) because it better explains the arguments we advance when we engage with proposed revisionary analyses. A key idea is that analytic claims can emerge in the course of debate without change of meaning, so that our acceptance (perhaps late in the debate) of some analyticity can fix the meaning of a word as we used it all along. The discussion focuses on Haslanger’s revisionary analysis of gender.

OBJECTIVE: To develop a technique for remote sensing of systemic blood oxygenation using red-eye pupil reflection.APPROACH: The ratio of the intensities of light from the bright pupil reflections at oxygen sensitive and isosbestic wavelengths is shown to be sensitive to the oxygenation of blood in the eye. A conventional retinal camera, fitted with an Image Replicating Imaging Spectrometer, was used at standoff range to record snapshot spectral images of the face and eyes at eight different wavelengths. In our pilot study we measured optical-density ratios (ODRs) of pupil reflections at wavelengths of 780nm and 800nm, simultaneous with pulse oximetry, for ten healthy human subjects under conditions of normoxia and mild hypoxia (15% oxygen). The low absorption at these infrared wavelengths localises the sensing to the choroid. We propose that this can be used for as a proxy for systemic oximetry.MAIN RESULTS: A significant reduction (P < 0.001) in ODR of the pupil images was observed during hypoxia and returned to baseline on resumption of normoxia. We demonstrate that measurement of the choroidal ODR can be used to detect changes in blood oxygenation that correlate positively with pulse oximetry and with a noise-equivalent oximetry precision of 0.5%.SIGNIFICANCE: We describe a new method to remotely and non-invasively sense the oxygen saturation of choroidal blood. The methodology provides a proxy for remote sensing of cerebral and systemic blood oxygenation. We demonstrate the technique at short range but it has potential for systemic oximetry at large standoff ranges.

Kaplan (1989) famously claimed that monsters—operators that shift the context—do not exist in English and “could not be added to it”. Several re- cent theorists have pointed out a range of data that seem to refute Kaplan’s claim, but others (most explicitly Stalnaker 2014) have offered a principled argument that monsters are impossible. This paper interprets and resolves the dispute. Contra appearances, this is no dry, technical matter: it cuts to the heart of a deep disagreement about the fundamental structure of a semantic theory. We argue that: (i) the interesting notion of a monster is not an operator that shifts some formal parameter, but rather an operator that shifts parameters that play a certain theoretical role; (ii) one cannot determine whether a given semantic theory allows monsters simply by look- ing at the formal semantics; (iii) theories which forbid shifting the formal “context” parameter are perfectly compatible with the existence of monsters (in the interesting sense). We explain and defend these claims by contrasting two kinds of semantic theory—Kaplan’s (1989) and Lewis’s (1980). Postprint

The main aim of this paper is to highlight the need to address the conceptual problem of ‘implicit knowledge’ or ‘implicit cognition’ — a notion especially important in the study of the nonverbal minds of animals and infants. We review some uses of the term ‘implicit’ in psychology and allied disciplines, and conclude that conceptual clarification of this notion is not only lacking, but largely avoided and reduced to a methodological problem. We propose that this elusive notion is central in the study not only of animal and infant minds, but also the human adult mind. Some promising approaches in developmental and evolutionary psychology towards innovative conceptualization of implicit knowledge remain conceptually underdeveloped and in need of reconsideration and re-elaboration. We conclude by suggesting that the challenge of implicit cognition and nonverbal minds will only be solved through a concerted interdisciplinary approach between psychology and other disciplines.

The theme of The Nutrition Society Spring Conference 2017 was on the interaction between nutrition and exercise for promoting healthy ageing, maintaining cognitive function and improving the metabolic health of the population. The importance of this theme is highlighted by the public health issues surrounding obesity, diabetes and the age-related loss of skeletal muscle mass (sarcopenia). The opening symposium provided a historical perspective of both invasive and non-invasive methodologies for measuring exercise energetics and energy balance. Data derived from these techniques underpin current understanding regarding the metabolic response to nutrition and exercise. Further symposia examined the importance of skeletal muscle for healthy ageing in older men and postmenopausal women. From a nutritional perspective, the potential for animal- v. plant-based protein sources to offset the age-related decline in muscle mass was discussed. The day concluded by discussing the link(s) between nutrition, exercise and brain function. Day 2 commenced with examples of applied equine research illustrating the link between nutrition/exercise and insulin resistance to those of a human model. The final symposium examined the combined role of nutrition and exercise in reducing risk of type 2 diabetes and dyslipidaemia. The overall conclusion from the meeting was that the interaction between diet and physical activity confers greater benefits to human health and performance than either component alone.

Synopsis of clinical issues associated with the complexity of compartment syndromes and current diagnostic limitations Comprehending the metabolic capacity of active skeletal muscle and its constant need for energy Understanding the principle of an ischemic threshold and the localised techniques that are employed by muscle to counteract progressive ischaemia Investigating the potential for tissue concentrations of key biochemical molecules involved in aerobic and anaerobic respiration to become markers of ischaemia Investigating the role of direct tissue pH monitoring to become a future objective measure of muscle metabolic status related to ischaemia irrespective of the cause

Purpose: The purpose of this experiment was to assess performance during repeated sprints utilizing self-selected recovery intervals in youth football (soccer) players at different stages of maturation. Methods: Quota sampling method was used to recruit 14 prepeak height velocity (PHV) and 14 post-PHV participants for the study (N = 28; age = 13 [0.9] y, stature = 162.5 [10.8] cm, mass = 50.2 [12.7] kg). Players performed repeated sprints comprising 10 × 30 m efforts under 2 experimental conditions: using 30-second and self-selected recovery intervals. Magnitude of effects for within- and between-group differences were reported using effect size (ES) statistics ± 90% confidence intervals and percentage differences. Results: The decline in sprint performance was likely lower in the pre-PHV compared with the post-PHV group during the standardized recovery trial (between-group difference = 37%; ES = 0.41 ± 0.51), and likely lower in the post-PHV group during the self-selected recovery trial (between-group difference = 50%; ES = 0.45 ± 0.54). Mean recovery duration was likely shorter in the pre-PHV compared with the post-PHV group during the self-selected recovery trial (between-group difference = 26.1%; ES = 0.47 ± 0.45). Conclusion: This is the first study to show that during repeated sprints with self-selected recovery, pre-PHV children have an impaired ability to accurately interpret physical capabilities in the context of the task compared with post-PHV adolescents.

This chapter defends a view of semantics on which developing a semantic theory closely resembles developing a scale of measurement. The view helps explain how semantics has made so much progress despite deep disagreements about the target of semantic theorizing (e.g., between those who maintain that semantics is characterizing something psychological, and those who maintain that it is characterizing something social), how appeals to set-theoretic abstracta make sense despite Benacerraf-style worries and despite the fact that set-theoretic entities fit badly with standard (e.g., causal) metasemantic views, and why the threat of radical context sensitivity does not undermine the semantic project.

This Introduction aims to acquaint the reader with some of the main views on the foundations of natural language semantics, to discuss the type of phenomena semanticists study, and to give some basic technical background in compositional model-theoretic semantics necessary to understand the chapters in this collection. Topics discussed include truth conditions, compositionality, context-sensitivity, dynamic semantics, the relation of formal semantic theories to the theoretical apparatus of reference and propositions current in much philosophy of language, what semantic theories aim to explain, realism, the metaphysics of language and different views of the relation between languages and speakers, and the epistemology of semantics.

Philosophical Progress defends the idea that philosophy makes progress, against sceptics who maintain that ‘philosophical problems are perennials for which it is pointless to expect a solution’ [vi...

Pursuing development and conservation goals often requires thinking and planning across terrestrial, freshwater and marine realms because many threats and social–ecological processes transcend realm boundaries. Consequently, effective conservation planning must consider the social and ecological links between realms and follow a cross-realm approach to allocate land/water uses and conservation actions to mitigate cross-realm threats and maintain cross-realm ecological processes. Cross-realm planning requires integrating multiple objectives for conservation and development, and assessing the potential co-benefits and trade-offs between them under alternative development scenarios. Despite progress in cross-realm planning theory, few fully-integrated and applied cross-realm plans exist. The gaps between research and implementation are not unique to cross-realm planning, but are accentuated by the complexity of spatial decision-making entailed. Based on a collaborative process including scientists, resource managers and policy-makers, we developed an operational framework for cross-realm planning based on up-to-date thinking in conservation science, but offering practical guidance to operationalise real-world planning. Our approach has a strong theoretical basis while addressing the visions and needs of decision-makers. We discuss the foundations and limitations of current approaches in cross-realm planning, describe key requirements to undertake this approach, and present a real-world application of our framework.

Leaving aside Lewis Carroll, George Eliot was almost certainly the most mathematically proficient novelist of the mid-Victorian age. She also had a strong interest and belief in education, particul...

Australia is the custodian of a diverse range of continental and oceanic islands. From Heard and Macquarie in the sub-Antarctic, to temperate Lord Howe and Norfolk, to the tropical Cocos (Keeling) Islands and the islands of the Great Barrier Reef, Australia’s islands contain some of the nation’s most iconic fauna, flora and ecosystems. They are a refuge for over 35% of Australia’s threatened species and for many others declining on mainland Australia. They also have significant cultural value, especially for Indigenous communities, and economic value as centres for tourism. Australian Island Arks presents a compelling case for restoring and managing islands to conserve our natural heritage. With contributions from island practitioners, researchers and policy-makers, it reviews current island management practices and discusses the need and options for future conservation work. Chapters focus on the management of invasive species, threatened species recovery, conservation planning, Indigenous cultural values and partnerships, tourism enterprises, visitor management, and policy and legislature. Case studies show how island restoration and conservation approaches are working in Australia and what the emerging themes are for the future. Australian Island Arks will help island communities, managers, visitors and decision-makers to understand the current status of Australia’s islands, their management challenges, and the opportunities that exist to make best use of these iconic landscapes.

Francois Recanati’s Mental Files (Oxford: Oxford University Press, 2012) presents a picture of the mind on which mental representations are indexical and transparent. I dispute this picture: there is no clear case for regarding mental representations as indexical, and there are counterexamples to transparency. Postprint

At rest, administration of the short-chain fatty acid acetate suppresses fat oxidation without affecting carbohydrate utilization. The combined effect of increased acetate availability and exercise on substrate utilization is, however, unclear. With local ethics approval, we studied the effect of ingesting either sodium acetate (NaAc) or sodium bicarbonate (NaHCO3) at a dose of 4 mmol·kg-1 body mass 90 min before completing 120 min of exercise at 50% VO2peak. Six healthy young men completed the trials after an overnight fast and ingested the sodium salts in randomized order. As expected NaAc ingestion decreased resting fat oxidation (mean ± SD; 0.09 ± 0.02 vs. 0.07 ± 0.02 g·min-1 pre- and post-ingestion respectively, p < .05) with no effect upon carbohydrate utilization. In contrast, NaHCO3 ingestion had no effect on substrate utilization at rest. In response to exercise, fat and CHO oxidation increased in both trials, but fat oxidation was lower (0.16 ± 0.10 vs. 0.29 ± 0.11 g·min-1, p < .05) and carbohydrate oxidation higher (1.67 ± 0.35 vs. 1.44 ± 0.22 g·min-1, p < .05) in the NaAc trial compared with the NaHCO3 trial during the first 15 min of exercise. Over the final 75 min of exercise an increase in fat oxidation and decrease in carbohydrate oxidation was observed only in the NaAc trial. These results demonstrate that increasing plasma acetate concentration suppresses fat oxidation both at rest and at the onset of moderate-intensity exercise.

Purpose:To examine the physiological and perceptual responses of youth footballers to a repeated sprint protocol employing standardized and self-selected recovery.Methods:Eleven male participants (13.7 ± 1.1 years) performed a repeated sprint assessment comprising 10 × 30 m efforts. Employing a randomized cross-over design, repeated sprints were performed using 30 s and self-selected recovery periods. Heart rate was monitored continuously with ratings of perceived exertion (RPE) and lower body muscle power measured 2 min after the final sprint. The concentration of blood lactate was measured at 2, 5 and 7 min post sprinting. Magnitude of effects were reported using effect size (ES) statistics ± 90% confidence interval and percentage differences. Differences between trials were examined using paired student t tests (p < .05).Results:Self-selected recovery resulted in most likely shorter recovery times (57.7%; ES 1.55 ± 0.5; p < .01), a most likely increase in percentage decrement (65%; ES 0.36 ± 0.21; p = .12), very likely lower heart rate recovery (-58.9%; ES -1.10 ± 0.72; p = .05), and likely higher blood lactate concentration (p = .08–0.02). Differences in lower body power and RPE were unclear (p > .05).Conclusion:Self-selected recovery periods compromise repeated sprint performance.

My concern [...] will be with the contrast between different lessons that different philosophers think should be learned from the story Kripke told. The account of the phenomena, and of the apparatus used to describe them, that I want to defend (and to attribute to Kripke) can be seen as a variation on, and development of, the skeptical lesson about a priori knowledge and truth taught by Quine. Robert Stalnaker (2001: 188-9)

It has long been widely agreed that some concepts can be possessed only by those who have undergone a certain type of phenomenal experience. Orthodoxy among contemporary philosophers of mind has it that these phenomenal concepts provide the key to understanding many disputes between physicalists and their opponents, and in particular offer an explanation of Mary’s predicament in the situation exploited by Frank Jackson's knowledge argument. I reject the orthodox view; I deny that there are phenomenal concepts. My arguments exploit the sort of considerations that are typically used to motivate externalism about mental content. Although physicalists often appeal to phenomenal concepts to defend their view against the knowledge argument, I argue that this is a mistake. The knowledge argument depends on phenomenal concepts; if there are no phenomenal concepts, then the knowledge argument fails.

It is widely believed that Twin-Earth-style thought experiments show that the contents of a person's thoughts fail to supervene on her intrinsic properties. Several recent philosophers have made the further claim that Twin-Earth-style thought experiments produce metaphysically necessary conditions for the possession of certain concepts. I argue that the latter view is false, and produce counterexamples to several proposed conditions. My thesis is of particular interest because it undermines some attempts to show that externalism is incompatible with privileged access.

This study examined whether left ventricular function was reduced during 3 h of semi-recumbent ergometer cycling at 70% of maximal oxygen uptake while preload to the heart was maintained via saline infusion. Indices of left ventricular systolic function (end-systolic blood pressure–volume relationship, SBP/ESV) and diastolic filling (ratio of early to late peak filling velocities into the left ventricle, E:A) were calculated during recovery and compared with baseline resting data. During exercise in seven healthy, trained male subjects, an arterial catheter allowed continuous assessment of arterial pressure, stroke volume (SV), cardiac output () and an index of contractility (dP/dtmax). A venous catheter assessed that central venous pressure (CVP) was maintained throughout rest, exercise and 10 min into recovery. Both systolic blood pressure and heart rate (HR) increased with the onset of exercise (from 132 ± 5 to 185 ± 19 mmHg and from 66 ± 9 to 135 ± 23 beats min−1; increases from rest to the end of the first 5 min of exercise in SBP and HR, respectively) but systolic blood pressure did not change from 30 to 180 min of exercise (∼150 mmHg), while heart rate only increased by 8 ± 9 beats min−1 (means ±s.d.; P > 0.05). The attenuated increase in HR compared with other studies suggests that the maintained CVP (∼5 mmHg) helped to prevent cardiovascular drift in this protocol. Stroke volume, and dP/dtmax were all increased with the onset of exercise (from 85 ± 8 to 120 ± 18 ml, from 5.4 ± 1.3 to 16.5 ± 3.3 l min−1 and from 14.4 ± 4 to 28 ± 8 mmHg s−1; values from rest to the end of the first 5 min of exercise for SV, and dP/dtmax, respectively) and were maintained during exercise. There was no difference in the SBP/ESV ratio from pre- to postexercise. Conversely, E:A was reduced from 2.0 ± 0.4 to 1.6 ± 0.5 postexercise (P < 0.05), returning to normal values at 24 h postexercise. This change in diastolic filling could not be fully explained (r2= 0.39) by an increased heart rate and, with CVP unchanged, it is likely to represent some depression of intrinsic relaxation properties of left ventricular myocytes. Three hours of semi-supine cycling resulted in no evidence of a depression in left ventricular systolic function, while left ventricular diastolic function declined postexercise.

The present study examined the effect of elevated temperature on muscle energy turnover during dynamic exercise. Nine male subjects performed 10 min of dynamic knee-extensor exercise at an intensity of 43 W (SD 10) and a frequency of 60 contractions per minute. Exercise was performed under normal (C) and elevated muscle temperature (HT) through passive heating. Thigh oxygen uptake (V̇o2) was determined from measurements of thigh blood flow and femoral arterial-venous differences for oxygen content. Anaerobic energy turnover was estimated from measurements of lactate release as well as muscle lactate accumulation and phosphocreatine utilization based on analysis of muscle biopsies obtained before and after each exercise. At the start of exercise, muscle temperature was 34.5°C (SD 1.7) in C compared with 37.2°C (SD 0.5) during HT ( P < 0.05). Thigh V̇o2after 3 min was 0.52 l/min (SD 0.11) in C and 0.63 l/min (SD 0.13) in HT, and at the end of exercise it was 0.60 l/min (SD 0.14) and 0.61 l/min (SD 0.10) in C and HT, respectively (not significant). Total lactate release was the same between the two temperature conditions, as was muscle lactate accumulation and PCr utilization. Total ATP production (aerobic + anaerobic) was the same between each temperature condition [505.0 mmol/kg (SD 107.2) vs. 527.1 mmol/kg (SD 117.6); C and HT, respectively]. In conclusion, within the range of temperatures studied, passively increasing muscle temperature before exercise has no effect on muscle energy turnover during dynamic exercise.

BackgroundPlatelet and endothelial activation has been shown to be increased in patients with intermittent claudication (IC). Recent studies have suggested that exercise may induce further platelet activation. The aims of this study were to investigate the effect of exercising to maximum walking distance on platelet and endothelial function in patients with intermittent claudication who were receiving statin and aspirin therapy compared with age matched healthy controls.MethodsPlatelet aggregation through COX-mediated and thrombin receptor activator peptide (TRAP)-stimulated GPIIb/IIIa pathways was measured by the Ultegra point of care system in 20 patients with IC on aspirin and 20 healthy volunteers before, immediately and 1h after exercising to treadmill maximal walking distance (MWD). Soluble P-selectin, vWF and sICAM were measured using an enzyme linked immuno-sorbent assay technique.ResultsBaseline platelet aggregation was significantly reduced in patients with IC compared to volunteers (p

PURPOSE: At present, there is little scientific evidence that postexercise manual massage has any effect on the factors associated with the recovery process. The purpose of this study was to compare the effects of massage against a resting control condition upon femoral artery blood flow (FABF), skin blood flow (SKBF), skin (SKT), and muscle (MT) temperature after dynamic quadriceps exercise. METHODS: Thirteen male volunteers participated in 3 x 2-min bouts of concentric quadriceps exercise followed by 2 x 6-min bouts of deep effleurage and pétrissage massage or a control (rest) period of similar duration in a counterbalanced fashion. Measures of FABF, SKBF, SKT, MT, blood lactate concentration (BLa), heart rate (HR), and blood pressure (BP) were taken at baseline, immediately after exercise, as well as at the midpoint and end of the massage/rest periods. Data were analyzed by two-way ANOVA. RESULTS: Significant main effects were found for all variables over time due to effects of exercise. Massage to the quadriceps did not significantly elevate FABF (end-massage 760 +/- 256 vs end-control 733 +/- 161 mL x min(-1)), MT, BL, HR, and BP over control values (P < 0.05). SKBF (end-massage 150 +/- 49 vs end control 6 +/- 4 au) SKT (end-massage 32.2 +/- 0.9 vs end-control 31.1 +/- 1.3degreesC) were elevated after the application of massage compared with the control trial (P < 0.05). CONCLUSION: From these data it is proposed that without an increase in arterial blood flow, any increase in SKBF is potentially diverting flow away from recovering muscle. Such a response would question the efficacy of massage as an aid to recovery in postexercise settings.