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6. The impact of treatment with avacopan on health-related quality of life in antineutrophil cytoplasmic antibody-associated vasculitis: a post-hoc analysis of data from the ADVOCATE trial

Author

Au Peh, Chen, Chakera, Aron, Cooper, Bruce, Kurtkoti, Jagadeesh, Langguth, Daman, Levidiotis, Vicki, Luxton, Grant, Mount, Peter, Mudge, David, Noble, Euan, Phoon, Richard, Ranganathan, Dwarakanathan, Ritchie, Angus, Ryan, Jessica, Suranyi, Michael, Rosenkranz, Alexander, Lhotta, Karl, Kronbichler, Andreas, Demoulin, Nathalie, Bovy, Christophe, Hellemans, Rachel, Hougardy, Jean-Michel, Sprangers, Ben, Wissing, Karl Martin, Pagnoux, Christian, Barbour, Sean, Brachemi, Soumeya, Cournoyer, Serge, Girard, Louis-Philippe, Laurin, Louis-Philippe, Liang, Patrick, Philibert, David, Walsh, Michael, Tesar, Vladimir, Becvar, Radim, Horak, Pavel, Rychlik, Ivan, Szpirt, Wladimir, Dieperink, Hans, Gregersen, Jon Waarst, Ivarsen, Per, Krarup, Elizabeth, Lyngsoe, Cecilie, Rigothier, Claire, Augusto, Jean-Francois, Belot, Alexandre, Chauveau, Dominique, Cornec, Divi, Jourde-Chiche, Noemie, Ficheux, Maxence, Karras, Alexandre, Klein, Alexandre, Maurier, Francois, Mesbah, Rafik, Moranne, Olivier, Neel, Antoine, Quemeneur, Thomas, Saadoun, David, Terrier, Benjamin, Zaoui, Philippe, Schaier, Matthias, Benck, Urs Tobias, Bergner, Raoul, Busch, Martin, Floege, Juergen, Grundmann, Franziska, Haller, Hermann, Haubitz, Marion, Hellmich, Bernhard, Henes, Joerg Christoph, Hohenstein, Bernd, Hugo, Christian, Iking-Konert, Christof, Arndt, Fabian, Kubacki, T, Kotter, Ina, Lamprecht, Peter, Lindner, Tom, Halbritter, Jan, Mehling, Heidrun, Schönermarck, Ulf, Venhoff, Nils, Vielhauer, Volker, Witzke, Oliver, Szombati, Istvan, Szucs, Gabriella, Garibotto, Giacomo, Alberici, Federico, Brunetta, Enrico, Dagna, Lorenzo, De Vita, Salvatore, Emmi, Giacomo, Gabrielli, Armando, Manenti, Lucio, Pieruzzi, Federico, Roccatello, Dario, Salvarani, Carlo, Harigai, Masayoshi, Dobashi, Hiroaki, Atsumi, Tatsuya, Fujimoto, Shoichi, Hagino, Noboru, Ihata, Atsushi, Kaname, Shinya, Kaneko, Yuko, Katagiri, Akira, Katayama, Masao, Kirino, Yohei, Kitagawa, Kiyoki, Komatsuda, Atsushi, Kono, Hajime, Kurasawa, Takahiko, Matsumura, Ryutaro, Mimura, Toshihide, Morinobu, Akio, Murakawa, Yohko, Naniwa, Taio, Nanki, Toshihiro, Ogawa, Noriyoshi, Oshima, Hisaji, Sada, Kenei, Sugiyama, Eiji, Takeuchi, Tohru, Taki, Hirofumi, Tamura, Naoto, Tsukamoto, Tatsuo, Yamagata, Kunihiro, Yamamura, Masahiro, van Daele, Paulus Leon Arthur, Rutgers, Abraham, Teng, Y.K. Onno, Walker, Robert, Chua, Ignatius, Collins, Michael, Rabindranath, Kannaiyan, de Zoysa, Janak, Svensson, My Hanna Sofia, Grevbo, Bard-Waldum, Kalstad, Synove, Little, Mark, Clarkson, Michael, Molloy, Eamonn, Agraz Pamplona, Irene, Anton, Jordi, Barrio Lucia, Vicente, Ciggaran, Secundino, Cinta Cid, Maria, Diaz Encarnacion, Montserrat, Fulladosa Oliveras, Xavier, Jose Soler, Maria, Marco Rusinol, Helena, Praga, Manuel, Quintana Porras, Luis, Segarra, Alfons, Bruchfeld, Annette, Segelmark, Marten, Soveri, Inga, Thomaidi, Eleni, Westman, Kerstin, Neumann, Thomas, Burnier, Michel, Daikeler, Thomas, Dudler, Jean, Hauser, Thomas, Seeger, Harald, Vogt, Bruno, Burton, James, Al Jayyousi, Reem, Amin, Tania, Andrews, Jacqueline, Baines, Laura Anne, Brogan, Paul, Dasgupta, Bhaskar, Doulton, Timothy William Ronald, Flossmann, Oliver, Griffin, Sian V., Harper, Janice Marian, Harper, Lorraine, Kidder, Dana, Klocke, Rainer, Lanyon, Peter Charles, Luqmani, Raashid, McLaren, John Stuart, Makanjuola, David Osagie, McCann, Liza, Nandagudi, Anupama C., Selvan, Shilpa, O'Riordan, Edmond, Patel, Mumtaz, Patel, Rajan Kantilal, Pusey, Charles Dickson, Rajakariar, Ravindra, Robson, Joanna C., Robson, Michael, Salama, Alan David, Smyth, Lucy, Sznajd, Jan, Taylor, Joanne, Sreih, Antonie G., Belilos, Elise, Bomback, Andrew S., Carlin, Jeffrey, Chang Chen Lin, Yih, Derebail, Vimal K., Dragoi, Serban, Dua, Anisha, Forbess, Lindsy, Geetha, Duvuru, Gipson, Patrick, Gohh, Reginald, Greenwood, Gregory Todd, Hugenberg, Steven T., Jimenez, Richard A.H., Kaskas, Marwan Omar, Kermani, Tanaz, Kivitz, Alan J., Koening, Curry, Langford, Carol A., Marder, Galina, Mohamed, Amr Ahmed El-Huesseini, Monach, Paul, Neyra, Nilda Roxana, Niemer, Gregory W., Niles, John, Obi, Reginald, Owens, Charles, Parks, Deborah L., Podoll, Amber S., Rovin, Brad, Sam, R, Shergy, William Julius, Silva, Arnold Lawrence, Specks, Ulrich, Spiera, Robert, Springer, Jason M., Striebich, Christopher Charles, Swarup, Areena, Thakar, Surabhi, Tiliakos, Athan N., Tsai, Yong, Waguespack, Dia R., Chester Wasko, Mary, Strand, Vibeke, Jayne, David R W, Horomanski, Audra, Yue, Huibin, Bekker, Pirow, and Merkel, Peter A

Published
2023
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7. Pregnancy History and Kidney Disease Progression Among Women Enrolled in Cure Glomerulonephropathy

Author

Reynolds, Monica L., Oliverio, Andrea L., Zee, Jarcy, Hendren, Elizabeth M., O’Shaughnessy, Michelle M., Ayoub, Isabelle, Almaani, Salem, Vasylyeva, Tetyana L., Twombley, Katherine E., Wadhwani, Shikha, Steinke, Julia M., Rizk, Dana V., Waldman, Meryl, Helmuth, Margaret E., Avila-Casado, Carmen, Alachkar, Nada, Nester, Carla M., Derebail, Vimal K., Hladunewich, Michelle A., and Mariani, Laura H.

Published
2023
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8. Precision nephrology identified tumor necrosis factor activation variability in minimal change disease and focal segmental glomerulosclerosis

Author

Mariani, Laura H., Eddy, Sean, AlAkwaa, Fadhl M., McCown, Phillip J., Harder, Jennifer L., Nair, Viji, Eichinger, Felix, Martini, Sebastian, Ademola, Adebowale D., Boima, Vincent, Reich, Heather N., El Saghir, Jamal, Godfrey, Bradley, Ju, Wenjun, Tanner, Emily C., Vega-Warner, Virginia, Wys, Noel L., Adler, Sharon G., Appel, Gerald B., Athavale, Ambarish, Atkinson, Meredith A., Bagnasco, Serena M., Barisoni, Laura, Brown, Elizabeth, Cattran, Daniel C., Coppock, Gaia M., Dell, Katherine M., Derebail, Vimal K., Fervenza, Fernando C., Fornoni, Alessia, Gadegbeku, Crystal A., Gibson, Keisha L., Greenbaum, Laurence A., Hingorani, Sangeeta R., Hladunewich, Michelle A., Hodgin, Jeffrey B., Hogan, Marie C., Holzman, Lawrence B., Jefferson, J. Ashley, Kaskel, Frederick J., Kopp, Jeffrey B., Lafayette, Richard A., Lemley, Kevin V., Lieske, John C., Lin, Jen-Jar, Menon, Rajarasee, Meyers, Kevin E., Nachman, Patrick H., Nast, Cynthia C., O’Shaughnessy, Michelle M., Otto, Edgar A., Reidy, Kimberly J., Sambandam, Kamalanathan K., Sedor, John R., Sethna, Christine B., Singer, Pamela, Srivastava, Tarak, Tran, Cheryl L., Tuttle, Katherine R., Vento, Suzanne M., Wang, Chia-shi, Ojo, Akinlolu O., Adu, Dwomoa, Gipson, Debbie S., Trachtman, Howard, and Kretzler, Matthias

Published
2023
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13. APOL1 genotype-associated morphologic changes among patients with focal segmental glomerulosclerosis

Author

Zee, Jarcy, McNulty, Michelle T., Hodgin, Jeffrey B., Zhdanova, Olga, Hingorani, Sangeeta, Jefferson, Jonathan Ashley, Gibson, Keisha L., Trachtman, Howard, Fornoni, Alessia, Dell, Katherine M., Reich, Heather N., Bagnasco, Serena, Greenbaum, Larry A., Lafayette, Richard A., Gipson, Debbie S., Brown, Elizabeth, Kretzler, Matthias, Appel, Gerald, Sambandam, Kamalanathan K., Tuttle, Katherine R., Chen, Dhruti, Atkinson, Meredith A., Hogan, Marie C., Kaskel, Frederick J., Meyers, Kevin E., O’Toole, John, Srivastava, Tarak, Sethna, Christine B., Hladunewich, Michelle A., Lin, JJ, Nast, Cynthia C., Derebail, Vimal K., Patel, Jiten, Vento, Suzanne, Holzman, Lawrence B., Athavale, Ambarish M., Adler, Sharon G., Lemley, Kevin V., Lieske, John C., Hogan, Jonathan J., Gadegbeku, Crystal A., Fervenza, Fernando C., Wang, Chia-Shi, Matar, Raed Bou, Singer, Pamela, Kopp, Jeffrey B., Barisoni, Laura, and Sampson, Matthew G.

Published
2021
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17. Persistent albuminuria and chronic kidney disease in adults with sickle cell anaemia: Results from a multicenter natural history study.

Author

Zhou, Laura Y., Derebail, Vimal K., Desai, Payal C., Elsherif, Laila, Patillo, Kammie L., McCune, Paula, Wichlan, David, Landes, Kristina, Ogu, Ugochi O., Nelson, Marquita, Loehr, Laura R., Cronin, Robert M., Tang, Yihan, Cai, Jianwen, and Ataga, Kenneth I.

Subjects
*SICKLE cell anemia, *CHRONIC kidney failure, *ALBUMINURIA, *LOGISTIC regression analysis, *GLOMERULAR filtration rate
Abstract

Summary Clinical and laboratory correlates of chronic kidney disease (CKD) in sickle cell anaemia remain incompletely defined. In a multicenter cohort study, we evaluated the prevalence of persistent albuminuria (PA) and characteristics associated with PA, albumin–creatinine ratio (ACR) and decreased estimated glomerular filtration rate (eGFR) using logistic, linear and multinomial regression models, respectively. Of 269 participants (median age: 30 years; 57.2% females), the prevalence of PA was 35.7%. Using baseline ACR values of <100 and ≥100 mg/g, the probabilities of PA were 30.0% and 94.6%, respectively. In multivariable logistic regression analyses, male sex (β = 0.80 [SE = 0.36], p = 0.024) and ACE inhibitors/ARBs use (β = 1.54 [SE = 0.43], p < 0.001) were associated with higher likelihoods of PA, while higher haemoglobin (β = −0.33 [SE = 0.13], p = 0.009) and HbF (β = −0.04 [SE = 0.02], p = 0.041) were associated with lower likelihoods of PA. In multivariable multinomial regression analyses, older age (β = 0.06 [SE = 0.02], p = 0.004) and higher alkaline phosphatase (β = 0.01 [SE = 0.00], p = 0.004) were associated with higher odds of having eGFR 60–90 versus eGFR>90 mL/min/1.73 m2 using the cystatin C‐based CKD‐EPI‐2012 equation. Additionally, higher systolic blood pressure (β = 0.11 [SE = 0.03], p = 0.001) and blood urea nitrogen (β = 0.45 [SE = 0.12], p < 0.001) were associated with higher odds, while higher haemoglobin (β = −1.22 [SE = 0.43], p = 0.004) was associated with lower odds of having eGFR<60 versus eGFR>90 mL/min/1.73 m2. PA and decreased eGFR are associated with measures of disease severity and comorbid conditions (Clinicaltrials.gov Identifier: NCT03277547). [ABSTRACT FROM AUTHOR]

Published
2024
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18. Proceedings of a Sickle Cell Disease Ontology workshop — Towards the first comprehensive ontology for Sickle Cell Disease

Author

Mulder, Nicola, Nembaware, Victoria, Adekile, Adekunle, Anie, Kofi A, Inusa, Baba, Brown, Biobele, Campbell, Andrew, Chinenere, Furahini, Chunda-Liyoka, Catherine, Derebail, Vimal K, Geard, Amy, Ghedira, Kais, Hamilton, Carol M, Hanchard, Neil A, Haendel, Melissa, Huggins, Wayne, Ibrahim, Muntaser, Jupp, Simon, Kamga, Karen Kengne, Knight-Madden, Jennifer, Lopez-Sall, Philomène, Mbiyavanga, Mamana, Munube, Deogratias, Nirenberg, Damian, Nnodu, Obiageli, Ofori-Acquah, Solomon Fiifi, Ohene-Frempong, Kwaku, Opap, Kenneth Babu, Panji, Sumir, Park, Miriam, Pule, Gift, Royal, Charmaine, Sangeda, Raphael, Tayo, Bamidele, Treadwell, Marsha, Tshilolo, Léon, and Wonkam, Ambroise

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Pediatric, Orphan Drug, Rare Diseases, Pain Research, Sickle Cell Disease, Hematology, Good Health and Well Being
Abstract

Sickle cell disease (SCD) is a debilitating single gene disorder caused by a single point mutation that results in physical deformation (i.e. sickling) of erythrocytes at reduced oxygen tensions. Up to 75% of SCD in newborns world-wide occurs in sub-Saharan Africa, where neonatal and childhood mortality from sickle cell related complications is high. While SCD research across the globe is tackling the disease on multiple fronts, advances have yet to significantly impact on the health and quality of life of SCD patients, due to lack of coordination of these disparate efforts. Ensuring data across studies is directly comparable through standardization is a necessary step towards realizing this goal. Such a standardization requires the development and implementation of a disease-specific ontology for SCD that is applicable globally. Ontology development is best achieved by bringing together experts in the domain to contribute their knowledge. The SCD community and H3ABioNet members joined forces at a recent SCD Ontology workshop to develop an ontology covering aspects of SCD under the classes: phenotype, diagnostics, therapeutics, quality of life, disease modifiers and disease stage. The aim of the workshop was for participants to contribute their expertise to development of the structure and contents of the SCD ontology. Here we describe the proceedings of the Sickle Cell Disease Ontology Workshop held in Cape Town South Africa in February 2016 and its outcomes. The objective of the workshop was to bring together experts in SCD from around the world to contribute their expertise to the development of various aspects of the SCD ontology.

Published
2016

21. Association of Sickle Cell Trait With Chronic Kidney Disease and Albuminuria in African Americans

Author

Naik, Rakhi P, Derebail, Vimal K, Grams, Morgan E, Franceschini, Nora, Auer, Paul L, Peloso, Gina M, Young, Bessie A, Lettre, Guillaume, Peralta, Carmen A, Katz, Ronit, Hyacinth, Hyacinth I, Quarells, Rakale C, Grove, Megan L, Bick, Alexander G, Fontanillas, Pierre, Rich, Stephen S, Smith, Joshua D, Boerwinkle, Eric, Rosamond, Wayne D, Ito, Kaoru, Lanzkron, Sophie, Coresh, Josef, Correa, Adolfo, Sarto, Gloria E, Key, Nigel S, Jacobs, David R, Kathiresan, Sekar, Bibbins-Domingo, Kirsten, Kshirsagar, Abhijit V, Wilson, James G, and Reiner, Alexander P

Subjects
Epidemiology, Health Sciences, Cardiovascular, Aging, Clinical Research, Kidney Disease, Atherosclerosis, Rare Diseases, Renal and urogenital, Adult, Black or African American, Aged, Albuminuria, Cohort Studies, Female, Glomerular Filtration Rate, Humans, Male, Middle Aged, Prospective Studies, Renal Insufficiency, Chronic, Risk, Sickle Cell Trait, United States, Young Adult, Medical and Health Sciences, General & Internal Medicine, Biomedical and clinical sciences, Health sciences
Abstract

ImportanceThe association between sickle cell trait (SCT) and chronic kidney disease (CKD) is uncertain.ObjectiveTo describe the relationship between SCT and CKD and albuminuria in self-identified African Americans.Design, setting, and participantsUsing 5 large, prospective, US population-based studies (the Atherosclerosis Risk in Communities Study [ARIC, 1987-2013; n = 3402], Jackson Heart Study [JHS, 2000-2012; n = 2105], Coronary Artery Risk Development in Young Adults [CARDIA, 1985-2006; n = 848], Multi-Ethnic Study of Atherosclerosis [MESA, 2000-2012; n = 1620], and Women's Health Initiative [WHI, 1993-2012; n = 8000]), we evaluated 15,975 self-identified African Americans (1248 participants with SCT [SCT carriers] and 14,727 participants without SCT [noncarriers]).Main outcomes and measuresPrimary outcomes were CKD (defined as an estimated glomerular filtration rate [eGFR] of 30 mg/g or albumin excretion rate >30 mg/24 hours), and decline in eGFR (defined as a decrease of >3 mL/min/1.73 m2 per year). Effect sizes were calculated separately for each cohort and were subsequently meta-analyzed using a random-effects model.ResultsA total of 2233 individuals (239 of 1247 SCT carriers [19.2%] vs 1994 of 14,722 noncarriers [13.5%]) had CKD, 1298 (140 of 675 SCT carriers [20.7%] vs 1158 of 8481 noncarriers [13.7%]) experienced incident CKD, 1719 (150 of 665 SCT carriers [22.6%] vs 1569 of 8249 noncarriers [19.0%]) experienced decline in eGFR, and 1322 (154 of 485 SCT carriers [31.8%] vs 1168 of 5947 noncarriers [19.6%]) had albuminuria during the study period. Individuals with SCT had an increased risk of CKD (odds ratio [OR], 1.57 [95% CI, 1.34-1.84]; absolute risk difference [ARD], 7.6% [95% CI, 4.7%-10.8%]), incident CKD (OR, 1.79 [95% CI, 1.45-2.20]; ARD, 8.5% [95% CI, 5.1%-12.3%]), and decline in eGFR (OR, 1.32 [95% CI, 1.07-1.61]; ARD, 6.1% [95% CI, 1.4%-13.0%]) compared with noncarriers. Sickle cell trait was also associated with albuminuria (OR, 1.86 [95% CI, 1.49-2.31]; ARD, 12.6% [95% CI, 7.7%-17.7%]).Conclusions and relevanceAmong African Americans in these cohorts, the presence of SCT was associated with an increased risk of CKD, decline in eGFR, and albuminuria, compared with noncarriers. These findings suggest that SCT may be associated with the higher risk of kidney disease in African Americans.

Published
2014

24. The impact of treatment with avacopan on health-related quality of life in antineutrophil cytoplasmic antibody-associated vasculitis: a post-hoc analysis of data from the ADVOCATE trial

Author

Strand, Vibeke, primary, Jayne, David R W, additional, Horomanski, Audra, additional, Yue, Huibin, additional, Bekker, Pirow, additional, Merkel, Peter A, additional, Au Peh, Chen, additional, Chakera, Aron, additional, Cooper, Bruce, additional, Kurtkoti, Jagadeesh, additional, Langguth, Daman, additional, Levidiotis, Vicki, additional, Luxton, Grant, additional, Mount, Peter, additional, Mudge, David, additional, Noble, Euan, additional, Phoon, Richard, additional, Ranganathan, Dwarakanathan, additional, Ritchie, Angus, additional, Ryan, Jessica, additional, Suranyi, Michael, additional, Rosenkranz, Alexander, additional, Lhotta, Karl, additional, Kronbichler, Andreas, additional, Demoulin, Nathalie, additional, Bovy, Christophe, additional, Hellemans, Rachel, additional, Hougardy, Jean-Michel, additional, Sprangers, Ben, additional, Wissing, Karl Martin, additional, Pagnoux, Christian, additional, Barbour, Sean, additional, Brachemi, Soumeya, additional, Cournoyer, Serge, additional, Girard, Louis-Philippe, additional, Laurin, Louis-Philippe, additional, Liang, Patrick, additional, Philibert, David, additional, Walsh, Michael, additional, Tesar, Vladimir, additional, Becvar, Radim, additional, Horak, Pavel, additional, Rychlik, Ivan, additional, Szpirt, Wladimir, additional, Dieperink, Hans, additional, Gregersen, Jon Waarst, additional, Ivarsen, Per, additional, Krarup, Elizabeth, additional, Lyngsoe, Cecilie, additional, Rigothier, Claire, additional, Augusto, Jean-Francois, additional, Belot, Alexandre, additional, Chauveau, Dominique, additional, Cornec, Divi, additional, Jourde-Chiche, Noemie, additional, Ficheux, Maxence, additional, Karras, Alexandre, additional, Klein, Alexandre, additional, Maurier, Francois, additional, Mesbah, Rafik, additional, Moranne, Olivier, additional, Neel, Antoine, additional, Quemeneur, Thomas, additional, Saadoun, David, additional, Terrier, Benjamin, additional, Zaoui, Philippe, additional, Schaier, Matthias, additional, Benck, Urs Tobias, additional, Bergner, Raoul, additional, Busch, Martin, additional, Floege, Juergen, additional, Grundmann, Franziska, additional, Haller, Hermann, additional, Haubitz, Marion, additional, Hellmich, Bernhard, additional, Henes, Joerg Christoph, additional, Hohenstein, Bernd, additional, Hugo, Christian, additional, Iking-Konert, Christof, additional, Arndt, Fabian, additional, Kubacki, T, additional, Kotter, Ina, additional, Lamprecht, Peter, additional, Lindner, Tom, additional, Halbritter, Jan, additional, Mehling, Heidrun, additional, Schönermarck, Ulf, additional, Venhoff, Nils, additional, Vielhauer, Volker, additional, Witzke, Oliver, additional, Szombati, Istvan, additional, Szucs, Gabriella, additional, Garibotto, Giacomo, additional, Alberici, Federico, additional, Brunetta, Enrico, additional, Dagna, Lorenzo, additional, De Vita, Salvatore, additional, Emmi, Giacomo, additional, Gabrielli, Armando, additional, Manenti, Lucio, additional, Pieruzzi, Federico, additional, Roccatello, Dario, additional, Salvarani, Carlo, additional, Harigai, Masayoshi, additional, Dobashi, Hiroaki, additional, Atsumi, Tatsuya, additional, Fujimoto, Shoichi, additional, Hagino, Noboru, additional, Ihata, Atsushi, additional, Kaname, Shinya, additional, Kaneko, Yuko, additional, Katagiri, Akira, additional, Katayama, Masao, additional, Kirino, Yohei, additional, Kitagawa, Kiyoki, additional, Komatsuda, Atsushi, additional, Kono, Hajime, additional, Kurasawa, Takahiko, additional, Matsumura, Ryutaro, additional, Mimura, Toshihide, additional, Morinobu, Akio, additional, Murakawa, Yohko, additional, Naniwa, Taio, additional, Nanki, Toshihiro, additional, Ogawa, Noriyoshi, additional, Oshima, Hisaji, additional, Sada, Kenei, additional, Sugiyama, Eiji, additional, Takeuchi, Tohru, additional, Taki, Hirofumi, additional, Tamura, Naoto, additional, Tsukamoto, Tatsuo, additional, Yamagata, Kunihiro, additional, Yamamura, Masahiro, additional, van Daele, Paulus Leon Arthur, additional, Rutgers, Abraham, additional, Teng, Y.K. Onno, additional, Walker, Robert, additional, Chua, Ignatius, additional, Collins, Michael, additional, Rabindranath, Kannaiyan, additional, de Zoysa, Janak, additional, Svensson, My Hanna Sofia, additional, Grevbo, Bard-Waldum, additional, Kalstad, Synove, additional, Little, Mark, additional, Clarkson, Michael, additional, Molloy, Eamonn, additional, Agraz Pamplona, Irene, additional, Anton, Jordi, additional, Barrio Lucia, Vicente, additional, Ciggaran, Secundino, additional, Cinta Cid, Maria, additional, Diaz Encarnacion, Montserrat, additional, Fulladosa Oliveras, Xavier, additional, Jose Soler, Maria, additional, Marco Rusinol, Helena, additional, Praga, Manuel, additional, Quintana Porras, Luis, additional, Segarra, Alfons, additional, Bruchfeld, Annette, additional, Segelmark, Marten, additional, Soveri, Inga, additional, Thomaidi, Eleni, additional, Westman, Kerstin, additional, Neumann, Thomas, additional, Burnier, Michel, additional, Daikeler, Thomas, additional, Dudler, Jean, additional, Hauser, Thomas, additional, Seeger, Harald, additional, Vogt, Bruno, additional, Burton, James, additional, Al Jayyousi, Reem, additional, Amin, Tania, additional, Andrews, Jacqueline, additional, Baines, Laura Anne, additional, Brogan, Paul, additional, Dasgupta, Bhaskar, additional, Doulton, Timothy William Ronald, additional, Flossmann, Oliver, additional, Griffin, Sian V., additional, Harper, Janice Marian, additional, Harper, Lorraine, additional, Kidder, Dana, additional, Klocke, Rainer, additional, Lanyon, Peter Charles, additional, Luqmani, Raashid, additional, McLaren, John Stuart, additional, Makanjuola, David Osagie, additional, McCann, Liza, additional, Nandagudi, Anupama C., additional, Selvan, Shilpa, additional, O'Riordan, Edmond, additional, Patel, Mumtaz, additional, Patel, Rajan Kantilal, additional, Pusey, Charles Dickson, additional, Rajakariar, Ravindra, additional, Robson, Joanna C., additional, Robson, Michael, additional, Salama, Alan David, additional, Smyth, Lucy, additional, Sznajd, Jan, additional, Taylor, Joanne, additional, Sreih, Antonie G., additional, Belilos, Elise, additional, Bomback, Andrew S., additional, Carlin, Jeffrey, additional, Chang Chen Lin, Yih, additional, Derebail, Vimal K., additional, Dragoi, Serban, additional, Dua, Anisha, additional, Forbess, Lindsy, additional, Geetha, Duvuru, additional, Gipson, Patrick, additional, Gohh, Reginald, additional, Greenwood, Gregory Todd, additional, Hugenberg, Steven T., additional, Jimenez, Richard A.H., additional, Kaskas, Marwan Omar, additional, Kermani, Tanaz, additional, Kivitz, Alan J., additional, Koening, Curry, additional, Langford, Carol A., additional, Marder, Galina, additional, Mohamed, Amr Ahmed El-Huesseini, additional, Monach, Paul, additional, Neyra, Nilda Roxana, additional, Niemer, Gregory W., additional, Niles, John, additional, Obi, Reginald, additional, Owens, Charles, additional, Parks, Deborah L., additional, Podoll, Amber S., additional, Rovin, Brad, additional, Sam, R, additional, Shergy, William Julius, additional, Silva, Arnold Lawrence, additional, Specks, Ulrich, additional, Spiera, Robert, additional, Springer, Jason M., additional, Striebich, Christopher Charles, additional, Swarup, Areena, additional, Thakar, Surabhi, additional, Tiliakos, Athan N., additional, Tsai, Yong, additional, Waguespack, Dia R., additional, and Chester Wasko, Mary, additional

Published
2023
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30. Prevalence of infertility and pregnancy loss among individuals with kidney disease in the Hispanic Community Health Study/Study of Latinos.

Author

Reynolds, Monica L, Loehr, Laura R, Hogan, Susan L, Hu, Yichun, Isasi, Carmen R, Cordero, Christina, Ricardo, Ana C, Lash, James P, and Derebail, Vimal K

Subjects
KIDNEY disease treatments, RESEARCH, HYSTERECTOMY, CONFIDENCE intervals, HEALTH services accessibility, MISCARRIAGE, HISPANIC Americans, SELF-evaluation, MULTIPLE regression analysis, MENSTRUATION, PUBLIC health, INFERTILITY, KIDNEY diseases, RISK assessment, DISEASE prevalence, DESCRIPTIVE statistics, RESEARCH funding, STATISTICAL correlation, ODDS ratio, STATISTICAL sampling, DATA analysis software, WOMEN'S health, DISEASE risk factors, DISEASE complications
Abstract

Background: Hispanic/Latino individuals are less likely to receive optimal treatment for chronic kidney disease than non-Hispanic whites. This may be particularly detrimental for women of reproductive age as chronic kidney disease increases risk for infertility, menstrual irregularities, and pregnancy loss. While these maternal outcomes have been associated with advanced chronic kidney disease, their occurrence in early chronic kidney disease is unclear. Objectives/Design: Using baseline (2008–2011) and second study visit (2014–2017) data from the Hispanic Community Health Study/Study of Latinos, we retrospectively assessed the prevalence of chronic kidney disease as well as the association between chronic kidney disease and self-reported infertility, cessation of menses, hysterectomy, and nonviable pregnancy loss (experienced at less than 24 weeks gestation) in women of reproductive age (18–45 years). Methods: Multivariable survey logistic regression analyses determined the unadjusted and multivariable-adjusted prevalence odds ratios with 95% confidence intervals between chronic kidney disease and the separate outcomes. Results: Among 2589 Hispanic/Latino women included (mean age = 31.4 years), 4.6% were considered to have chronic kidney disease. In adjusted analyses, women with chronic kidney disease did not have a significantly increased odds of infertility (odds ratio = 1.02, 95% confidence interval = 0.42–2.49), cessation of menses (odds ratio = 1.25, 95% confidence interval = 0.52–3.04), or hysterectomy (odds ratio = 1.17, 95% confidence interval = 0.61–2.25) compared to those without chronic kidney disease. In those with chronic kidney disease, the adjusted odds of a nonviable pregnancy loss occurring after baseline visit were increased (odds ratio = 2.11, 95% confidence interval = 0.63–7.02) but not statistically significance. Conclusion: The presence of early stage chronic kidney disease did not confer a significant risk of infertility, cessation of menses, or nonviable pregnancy loss. Plain language summary: The Hispanic Community Health Study/Study of Latinos is a population-based study of over 16,000 Hispanic/Latino individuals throughout the United States. Within this cohort, we assessed the prevalence of chronic kidney disease in women of reproductive age (18–45 years old) and the associations between kidney disease and infertility, cessation of menses, and nonviable pregnancy loss (loss occurring before the 24th week of pregnancy). We found that kidney disease affected 1 in 20 women of reproductive age and those with kidney disease were more likely to have obesity, diabetes, and hypertension. Compared to those without kidney disease, the presence of kidney disease did not increase risk of infertility, cessation of menses, or nonviable pregnancy loss. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Contributors

Author

Agarwal, Rajiv, primary, Alfaadhel, Talal, additional, Andersen, Martin J., additional, Asplin, John Robert, additional, Avasare, Rupali S., additional, Bakris, George L., additional, Bansal, Amar D., additional, Baxi, Pravir V., additional, Berkoben, Michael, additional, Bieber, Scott D., additional, Buchkremer, Florian, additional, Burgner, Anna Marie, additional, Byrd, James Brian, additional, Cattran, Daniel, additional, Choudhury, Devasmita, additional, Granado, Rolando Claure-Del, additional, Denker, Bradley M., additional, Derebail, Vimal K., additional, Desnick, Robert J., additional, Lullo, Luca di, additional, Duronville, John V., additional, Eknoyan, Garabed, additional, Kateb, Mina El, additional, Elliott, William J., additional, Ennis, Jennifer L., additional, Fervenza, Fernando C., additional, Figlin, Robert A., additional, Galvin, Zita, additional, Garimella, Pranav S., additional, Gipson, Debbie S., additional, Gipson, Patrick E., additional, Goldfarb, David S., additional, Greenberg, Arthur, additional, Haller, Hermann, additional, Hiremath, Swapnil, additional, Horwitz, Edward J., additional, Hou, Susan, additional, Inker, Lesley A., additional, Irazabal, Maria V., additional, Irish, Ashley Bruce, additional, Jhaveri, Kenar D., additional, Jefferson, Jonathan Ashley, additional, Kalantar-Zadeh, Kamyar, additional, Kamil, Elaine S., additional, Kenny, Jon-Emile S., additional, Khoury, Charbel C., additional, Kohli, Jatinder, additional, Kovalik, Eugene C., additional, Kovesdy, Csaba P., additional, Kupin, Warren, additional, Lehrich, Ruediger W., additional, Lerma, Edgar V., additional, Levi, Moshe, additional, Lockridge, Joseph L., additional, Lopez, Jennifer, additional, Macedo, Etienne, additional, Mehrotra, Rajnish, additional, Mehta, Ravindra L., additional, Nachman, Patrick H., additional, Nadai, Carol, additional, Negrea, Lavinia Aura, additional, Nicolle, Lindsay E., additional, Norris, Keith C., additional, Novakovic, Alexander, additional, Olyaei, Ali J., additional, Pal, Sumanta Kumar, additional, Palevsky, Paul M., additional, Patel, Ami M., additional, Patney, Vikram, additional, Perazella, Mark A., additional, Pham, Phuong-Chi T., additional, Pham, Phuong-Thu T., additional, Pryor, Joseph B., additional, S. Ram, C. Venkata, additional, Rahman, MD, Mahboob, additional, Reisinger, Nathaniel, additional, Rocco, Michael V., additional, Ronco, Claudio, additional, Rosenberg, Mark E., additional, Rosner, Mitchell H., additional, Rudnick, Michael R., additional, Sabath, Ernesto, additional, Sarnak, Mark J., additional, Schell, Jane O., additional, Seay, N. Winn, additional, Sedor, John R., additional, Sethi, Akash Nair, additional, Shah, Anuja, additional, Shah, Lori, additional, Sherer, Benjamin A., additional, Singh, Harpreet, additional, Sinniah, Rajalingam, additional, Sloand, James A., additional, Sparks, Matthew A., additional, Sprague, Stuart M., additional, Steigerwalt, Susan Patricia, additional, Sternlicht, Hillel, additional, Stoller, Marshall L., additional, Thomas, Beje, additional, Toka, Hakan R., additional, Topf, Joel M., additional, Torres, Vicente E., additional, Trachtman, Howard, additional, Traynor, Carol, additional, Tucker, Bryan M., additional, Vogt, Beth A., additional, Wanchoo, Rimda, additional, Weir, Matthew R., additional, Whaley-Connell, Adam, additional, Whittier, William L., additional, Wish, Jay B., additional, Wong, Florence, additional, Wymer, David C., additional, Wymer, David T.G., additional, and Zand, Ladan, additional

Published
2019
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34. PRTN3 variant correlates with increased autoantigen levels and relapse risk in PR3-ANCA versus MPO-ANCA disease

Author

Chen, Dhruti P., primary, Aiello, Claudia P., additional, McCoy, DeMoris, additional, Stamey, Taylor, additional, Yang, Jiajin, additional, Hogan, Susan L., additional, Hu, Yichun, additional, Derebail, Vimal K., additional, Wu, Eveline Y., additional, Jennette, J. Charles, additional, Falk, Ronald J., additional, and Ciavatta, Dominic J., additional

Published
2023
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35. Contributors

Author

Abudayyeh, Ala, primary, Adrogué, Horacio J., additional, Allon, Michael, additional, Arif-Tiwari, Hina, additional, Barratt, Jonathan, additional, Berns, Jeffrey S., additional, Bjornstad, Petter, additional, Bomback, Andrew S., additional, Bowling, C. Barrett, additional, Braun, Daniela A., additional, Brewster, Ursula C., additional, Carson, John M., additional, Cattran, Daniel C., additional, Chandran, Sindhu, additional, Chapman, Arlene B., additional, Cherney, David, additional, Coca, Steven G., additional, Cohen, Debbie L., additional, Crawford, Brendan D., additional, Curhan, Gary C., additional, Dad, Taimur, additional, D'Agati, Vivette D., additional, Derebail, Vimal K., additional, De Vriese, An S., additional, de Zeeuw, Dick, additional, DuBose, Thomas D., additional, Emmett, Michael, additional, Evenepoel, Pieter, additional, Fairhead, Todd, additional, Falk, Ronald J., additional, Fervenza, Fernando C., additional, Finkel, Kevin W., additional, Födinger, Manuela, additional, Gbadegesin, Rasheed A., additional, Gehr, Todd W.B., additional, Gilbert, Scott J., additional, Gill, Jagbir S., additional, Gonwa, Thomas A., additional, Greenberg, Arthur, additional, Gregory, Martin C., additional, Herlitz, Leal, additional, Hildebrandt, Friedhelm, additional, Hladik, Gerald A., additional, Hladunewich, Michelle A., additional, Hoenig, Melanie P., additional, Hogan, Jonathan, additional, House, Andrew A., additional, Hutchison, Alastair J., additional, Ikizler, T. Alp, additional, Inker, Lesley A., additional, Ison, Michael G., additional, James, Matthew T., additional, Jennette, J. Charles, additional, Kain, Renate, additional, Kala, Jaya, additional, Kalantar-Zadeh, Kamyar, additional, Kalb, Bobby, additional, Kopp, Jeffrey B., additional, Knoll, Greg, additional, Kulkarni, Dhananjay P., additional, Lan, James, additional, Levey, Andrew S., additional, Lewis, Ed, additional, Linas, Stuart L., additional, Luciano, Randy L., additional, Lytvyn, Yuliya, additional, Macedo, Etienne, additional, Madias, Nicolaos E., additional, Martin, Diego R., additional, Matzke, Gary R., additional, Mehrotra, Rajnish, additional, Mehta, Ankit N., additional, Mehta, Ravindra L., additional, Meyers, Catherine M., additional, Misra, Madhukar, additional, Moe, Sharon M., additional, Nachman, Patrick H., additional, Nicolle, Lindsay E., additional, Nolin, Thomas D., additional, O'Hare, Ann M., additional, Pannu, Neesh, additional, Peixoto, Aldo J., additional, Perazella, Mark A., additional, Prochaska, Megan, additional, Provenzano, Laura Ferreira, additional, Quarles, L. Darryl, additional, Radhakrishnan, Jai, additional, Reddy, Bharathi, additional, Rizk, Dana V., additional, Ronco, Claudio, additional, Rosenberg, Avi Z., additional, Rosenblum, Norman D., additional, Sampson, Matthew G., additional, Sanders, Paul W., additional, Sarnak, Mark J., additional, Scheinman, Steven J., additional, Schnaper, H. William, additional, Schrauben, Sarah, additional, Semelka, Richard C., additional, Shirali, Anushree C., additional, Sica, Domenic A., additional, Sunder-Plassmann, Gere, additional, Sutherland, Richard W., additional, Szerlip, Harold M., additional, Kurella Tamura, Manjula, additional, Tangren, Jessica Sheehan, additional, Thurman, Joshua M., additional, Tonelli, Marcello, additional, Townsend, Raymond R., additional, Trachtman, Howard, additional, Turner, Jeffrey M., additional, Vardhan, Anand, additional, Verbalis, Joseph G., additional, Vincenti, Flavio G., additional, Vivarelli, Marina, additional, Voora, Raven, additional, Wadei, Hani M., additional, Warady, Bradley A., additional, Weidemann, Darcy K., additional, Weiner, Daniel E., additional, Whittier, William L., additional, Wilcox, Christopher S., additional, Wish, Jay B., additional, and Yeo, See Cheng, additional

Published
2018
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37. Malignancy risk in kidney transplant recipients exposed to immunosuppression pre-transplant for the treatment of glomerulonephritis.

Author

Massicotte-Azarniouch, David, Detwiler, Randal K, Hu, Yichun, Falk, Ronald J, Saha, Manish K, Hogan, Susan L, and Derebail, Vimal K

Subjects
KIDNEY transplantation, GLOMERULONEPHRITIS, IMMUNOSUPPRESSION, SKIN cancer, HEMATOLOGIC malignancies
Abstract

Background Kidney transplant patients with glomerulonephritis (GN) as their native disease may receive significant amounts of pre-transplant immunosuppression (PTI), which could increase the risk for development of malignancy post-transplant. Methods We conducted a single-center, retrospective study of kidney transplant recipients from January 2005 until May 2020. Patients with GN as their native kidney disease who received PTI for treatment of GN (n  = 184) were compared with a control cohort (n  = 579) of non-diabetic, non-PTI-receiving kidney transplant patients. We calculated hazard ratios (HR) with 95% confidence intervals (95% CI) for outcomes of first occurrence of solid or hematologic malignancy, non-melanoma skin cancer (NMSC) and post-transplant lymphoproliferative disorder (PTLD). Results Over a median follow-up of 5.7 years, PTI for GN was associated with significantly increased risk for malignancy compared with controls [13.0%  vs 9.7%, respectively; adjusted HR 1.82 (95% CI 1.10–3.00)], but not for NMSC [10.3% vs 11.4%, respectively; adjusted HR 1.09 (95% CI 0.64–1.83)] or PTLD [3.3% vs 3.1%, respectively; adjusted HR 1.02 (95% CI 0.40–2.61)]. The risk for malignancy was significantly increased in those who received cyclophosphamide [HR 2.59 (95% CI 1.48–4.55)] or rituximab [HR 3.82 (95% CI 1.69–8.65)] pre-transplant, and particularly in those who received both cyclophosphamide and rituximab, but not for calcineurin inhibitors or mycophenolate. Conclusion The use of PTI for treatment of GN, especially cyclophosphamide or even with rituximab, is associated with increased risk for development of solid or hematologic malignancy post-transplant. These data highlight potential risks with treatment of GN and underscore the importance of post-transplant malignancy surveillance in this patient population. [ABSTRACT FROM AUTHOR]

Published
2023
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38. Sex differences in progression of kidney disease in sickle cell disease

Author

Ataga, Kenneth I., primary, Zhou, Qingning, additional, Saraf, Santosh L., additional, Hankins, Jane S., additional, Ciccone, Emily J., additional, Loehr, Laura R., additional, Garrett, Melanie E., additional, Ashley-Koch, Allison E., additional, Cai, Jianwen, additional, Telen, Marilyn J., additional, and Derebail, Vimal K., additional

Published
2022
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41. Evaluating Equations for Estimated Glomerular Filtration Rate (eGFR) in Patients with Sickle Cell Disease (SCD)

Author

Derebail, Vimal K, primary, Zhou, Laura Y, additional, Elsherif, Laila, additional, Patillo, Kammie L, additional, Wichlan, David, additional, Landes, Kristina, additional, McCune, Paula, additional, Loehr, Laura R, additional, Cronin, Robert M, additional, Desai, Payal C, additional, Cai, Jianwen, additional, and Ataga, Kenneth I, additional

Published
2022
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43. Pharmacokinetics and Pharmacodynamics of Apixaban in Nephrotic Syndrome: Findings From a Phase 1a Trial

Author

Derebail, Vimal K., primary, Zhu, Jing, additional, Crawford, Matthew L., additional, Garnier, Julia R., additional, Martin, Karlyn A., additional, Skinner, Sarah, additional, Patel, Tejendra, additional, Froment, Anne, additional, Sketch, Margaret R., additional, Szeto, Andy H., additional, Patel, Sheel M., additional, Torrice, Chad D., additional, Tiefenbacher, Stefan, additional, Adcock, Dorothy M., additional, Grant, Russell P., additional, Key, Nigel S., additional, and Crona, Daniel J., additional

Published
2022
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45. Black and White Adults With CKD Hospitalized With Acute Kidney Injury: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study

Author

Muiru, Anthony N., primary, Yang, Jingrong, additional, Derebail, Vimal K., additional, Liu, Kathleen D., additional, Feldman, Harold I., additional, Srivastava, Anand, additional, Bhat, Zeenat, additional, Saraf, Santosh L., additional, Chen, Teresa K., additional, He, Jiang, additional, Estrella, Michelle M., additional, Go, Alan S., additional, Hsu, Chi-yuan, additional, Appel, Lawrence J., additional, Chen, Jing, additional, Cohen, Debbie L., additional, Lash, James P., additional, Nelson, Robert G., additional, Rahman, Mahboob, additional, Rao, Panduranga S., additional, Shah, Vallabh O., additional, and Unruh, Mark L., additional

Published
2022
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