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236 results on '"Depypere, Lieven"'

1. Diagnosis and Management of Esophageal Fistulas After Lung Transplantation: A Case Series

Author

Vanstraelen, Stijn, Vos, Robin, Dausy, Marie, Van Slambrouck, Jan, Vanluyten, Cedric, De Leyn, Paul, Coosemans, Willy, Decaluwé, Herbert, Van Veer, Hans, Depypere, Lieven, Bisschops, Raf, Demedts, Ingrid, Casaer, Michael P., Debaveye, Yves, De Vlieger, Greet, Godinas, Laurent, Verleden, Geert, Van Raemdonck, Dirk, Nafteux, Philippe, and Ceulemans, Laurens J.

Published
2024
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6. Neoadjuvant Chemoradiotherapy Versus Chemotherapy for the Treatment of Locally Advanced Esophageal Adenocarcinoma in the European Multicenter ENSURE Study

Author

Elliott, Jessie A., Klevebro, Fredrik, Mantziari, Styliani, Markar, Sheraz R., Goense, Lucas, Johar, Asif, Lagergren, Pernilla, Zaninotto, Giovanni, van Hillegersberg, Richard, van Berge Henegouwen, Mark I., Schäfer, Markus, Nilsson, Magnus, Hanna, George B., Reynolds, John V., Van Veer, Hans, Depypere, Lieven, Coosemans, Willy, Nafteux, Philippe, Carroll, Paul, Allison, Frances, Darling, Gail, Findlay, John M, Everden, Serenydd, Maynard, Nicholas D, Ariyarathenam, Arun, Sanders, Grant, Jaunoo, Shameen, Singh, Pritam, Parsons, Simon, Saunders, John, Vohra, Ravinder, Sinha, Aaditya, Tan, Benjamin HL., Whiting, John G, Boshier, Piers R, Phillips, Alexander W, Griffin, S Michael, Walker, Robert C., Underwood, Tim J, Piessen, Guillaume, Theisen, Jorg, Friess, Hans, Bruns, Christiane J., Schröder, Wolfgang, Collins, Chris G, McAnena, Oliver J, Rooney, Siobhan, Quinn, Aoife, Toale, Conor, Murphy, Thomas J, Ravi, Narayanasamy, Donohoe, Claire L, Scarpa, Marco, Bardini, Romeo, Degasperi, Silvia, Saadeh, Luca, Castoro, Carlo, Alfieri, Rita, Pinto, Eleonora, Mattara, Genny, Kalff, Marianne C, Gisbertz, Suzanne S, Berge Henegouwen, Mark I Van, van Hootegem, Sander JM, Lagarde, Sjoerd M, Lanschot, J Jan B van, Kingma, B Feike, Rurrda, Jelle P, van Hillegersberg, Richard, Kennedy, Raymond, Carey, P. Declan, Prodehl, Leanne, Lamb, Peter J, Skipworth, Richard JE, Cero, Mariagiulia Dal, Pera, Manuel, Huang, Biying, Linder, Gustav, Sundbom, Magnus, Mantziari, Styliani, Schäfer, Markus, and Demartines, Nicolas

Published
2023
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7. Lung Transplant Outcome From Selected Older Donors (≥70 Years) Equals Younger Donors (<70 Years): A Propensity-matched Analysis

Author

Vanluyten, Cedric, Vandervelde, Christelle M., Vos, Robin, Van Slambrouck, Jan, Fieuws, Steffen, De Leyn, Paul, Nafteux, Philippe, Decaluwé, Herbert, Van Veer, Hans, Depypere, Lieven, Jansen, Yanina, Provoost, An-Lies, Neyrinck, Arne P., Ingels, Catherine, Vanaudenaerde, Bart M., Godinas, Laurent, Dupont, Lieven J., Verleden, Geert M., Van Raemdonck, Dirk, and Ceulemans, Laurens J.

Published
2023
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8. Lung transplantation following controlled hypothermic storage with a portable lung preservation device: first multicenter European experience

Author

Provoost, An-Lies, primary, Novysedlak, Rene, additional, Van Raemdonck, Dirk, additional, Van Slambrouck, Jan, additional, Prisciandaro, Elena, additional, Vandervelde, Christelle M., additional, Barbarossa, Annalisa, additional, Jin, Xin, additional, Denaux, Karen, additional, De Leyn, Paul, additional, Van Veer, Hans, additional, Depypere, Lieven, additional, Jansen, Yanina, additional, Pirenne, Jacques, additional, Neyrinck, Arne, additional, Bouneb, Sofian, additional, Ingels, Catherine, additional, Jacobs, Bart, additional, Godinas, Laurent, additional, De Sadeleer, Laurens, additional, Vos, Robin, additional, Svorcova, Monika, additional, Vajter, Jaromir, additional, Kolarik, Jan, additional, Tavandzis, Janis, additional, Havlin, Jan, additional, Ozaniak Strizova, Zuzana, additional, Pozniak, Jiri, additional, Simonek, Jan, additional, Vachtenheim, Jiri, additional, Lischke, Robert, additional, and Ceulemans, Laurens J., additional

Published
2024
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9. Impact of anastomosis time during lung transplantation on primary graft dysfunction

Author

Vandervelde, Christelle M., Vos, Robin, Vanluyten, Cedric, Fieuws, Steffen, Verleden, Stijn E., Van Slambrouck, Jan, De Leyn, Paul, Coosemans, Willy, Nafteux, Philippe, Decaluwé, Herbert, Van Veer, Hans, Depypere, Lieven, Dauwe, Dieter F., De Troy, Erwin, Ingels, Catherine M., Neyrinck, Arne P., Jochmans, Ina, Vanaudenaerde, Bart M., Godinas, Laurent, Verleden, Geert M., Van Raemdonck, Dirk E., and Ceulemans, Laurens J.

Published
2022
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10. Comparing right- versus left-first implantation in off-pump sequential double-lung transplantation: an observational cohort study.

Author

Slambrouck, Jan Van, Decaluwé, Herbert, Vanluyten, Cedric, Vandervelde, Christelle M, Orlitová, Michaela, Beeckmans, Hanne, Schoenaers, Charlotte, Jin, Xin, Makarian, Roza S, Leyn, Paul De, Veer, Hans Van, Depypere, Lieven, Belmans, Ann, Vanaudenaerde, Bart M, Vos, Robin, Raemdonck, Dirk Van, and Ceulemans, Laurens J

Subjects
ARTIFICIAL blood circulation, EXTRACORPOREAL membrane oxygenation, LUNG transplantation, INTRAOPERATIVE care, TRANSPLANTATION of organs, tissues, etc.
Abstract

OBJECTIVES Historically, the perfusion-guided sequence suggests to first transplant the side with lowest lung perfusion. This sequence is thought to limit right ventricular afterload and prevent acute heart failure after first pneumonectomy. As a paradigm shift, we adopted the right-first implantation sequence, irrespective of lung perfusion. The right donor lung generally accommodates a larger proportion of the cardiac output. We hypothesized that the right-first sequence reduces the likelihood of oedema formation in the firstly transplanted graft during second-lung implantation. Our objective was to compare the perfusion-guided and right-first sequence for intraoperative extracorporeal membrane oxygenation (ECMO) need and primary graft dysfunction (PGD). METHODS A retrospective single-centre cohort study (2008–2021) including double-lung transplant cases (N  = 696) started without ECMO was performed. Primary end-points were intraoperative ECMO cannulation and PGD grade 3 (PGD3) at 72 h. Secondary end-points were patient and chronic lung allograft dysfunction-free survival. In cases with native left lung perfusion ≤50% propensity score adjusted comparison of the perfusion-guided and right-first sequence was performed. RESULTS When left lung perfusion was ≤50%, right-first implantation was done in 219 and left-first in 189 cases. Intraoperative escalation to ECMO support was observed in 10.96% of right-first versus 19.05% of left-first cases (odds ratio 0.448; 95% confidence interval 0.229–0.0.878; P  = 0.0193). PGD3 at 72 h was observed in 8.02% of right-first versus 15.64% of left-first cases (0.566; 0.263–1.217; P  = 0.1452). Right-first implantation did not affect patient or chronic lung allograft dysfunction-free survival. CONCLUSIONS The right-first implantation sequence in off-pump double-lung transplantation reduces need for intraoperative ECMO cannulation with a trend towards less PGD grade 3. [ABSTRACT FROM AUTHOR]

Published
2024
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11. An International Multicenter Study Exploring Whether Surveillance After Esophageal Cancer Surgery Impacts Oncological and Quality of Life Outcomes (ENSURE)

Author

Elliott, Jessie A., Markar, Sheraz R., Klevebro, Fredrik, Johar, Asif, Goense, Lucas, Lagergren, Pernilla, Zaninotto, Giovanni, van Hillegersberg, Richard, van Berge Henegouwen, Mark I., Nilsson, Magnus, Hanna, George B., Reynolds, John V., Van Veer, Hans, Depypere, Lieven, Coosemans, Willy, Nafteux, Philippe, Carroll, Paul, Allison, Frances, Darling, Gail, Findlay, John M, Everden, Serenydd, Maynard, Nicholas D, Ariyarathenam, Arun, Sanders, Grant, Jaunoo, Shameen, Singh, Pritam, Parsons, Simon, Saunders, John, Vohra, Ravinder, Sinha, Aaditya, HLTan, Benjamin, Whiting, John G, Boshier, Piers R, Phillips, Alexander W, Griffin, S Michael, Walker, Robert C, Underwood, Tim J, Piessen, Guillaume, Theisen, Jorg, Friess, Hans, Bruns, Christiane J, Schröder, Wolfgang, Collins, Chris G, McAnena, Oliver J, Rooney, Siobhan, Quinn, Aoife, Toale, Conor, Murphy, Thomas J, Ravi, Narayanasamy, Donohoe, Claire L, Scarpa, Marco, Bardini, Romeo, Degasperi, Silvia, Saadeh, Luca, Castoro, Carlo, Alfieri, Rita, Pinto, Eleonora, Mattara, Genny, Kalff, Marianne C, Gisbertz, Suzanne S, Van Berge Henegouwen, Mark I, van Hootegem, Sander JM, Lagarde, Sjoerd M, Wijnhoven, Bas PL, van Lanschot, J Jan B, Kingma, B Feike, Rurrda, Jelle P, van Hillegersberg, Richard, Kennedy, Raymond, Carey, P Declan, Prodehl, Leanne, Lamb, Peter J, Skipworth, Richard JE, Cero, Mariagiulia Dal, Pera, Manuel, Huang, Biying, Linder, Gustav, Sundbom, Magnus, Mantziari, Styliani, Schäfer, Markus, Allemann, Pierre, and Demartines, Nicolas

Published
2023
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12. Sex-related differences in oncologic outcomes, operative complications and health-related quality of life after curative-intent oesophageal cancer treatment: multicentre retrospective analysis

Author

MS CGO, Cancer, Mantziari, Styliani, Elliott, Jessie A., Markar, Sheraz R., Klevebro, Fredrik, Goense, Lucas, Johar, Asif, Lagergren, Pernilla, Zaninotto, Giovanni, van Hillegersberg, Richard, van Berge Henegouwen, Mark I., Schäfer, Markus, Nilsson, Magnus, Hanna, George B., Reynolds, John V., Van Veer, Hans, Depypere, Lieven, Coosemans, Willy, Nafteux, Philippe, Carroll, Paul, Allison, Frances, Darling, Gail, Findlay, John M., Everden, Serenydd, Maynard, Nicholas D., Ariyarathenam, Arun, Sanders, Grant, Jaunoo, Shameen, Singh, Pritam, Parsons, Simon, Saunders, John, Vohra, Ravinder, Sinha, Aaditya, Tan, Benjamin H.L., Whiting, John G., Boshier, Piers R., Phillips, Alexander W., Griffin, S. Michael, Walker, Robert C., Underwood, Tim J., Piessen, Guillaume, Theisen, Jorg, Friess, Hans, Bruns, Christiane J., Schröder, Wolfgang, Collins, Chris G., McAnena, Oliver J., Rooney, Siobhan, Quinn, Aoife, Toale, Conor, Murphy, Thomas J., Ravi, Narayanasamy, Donohoe, Claire L., Scarpa, Marco, Bardini, Romeo, Degasperi, Silvia, Saadeh, Luca, Castoro, Carlo, Alfieri, Rita, Pinto, Eleonora, Mattara, Genny, Kalff, Marianne C., Gisbertz, Suzanne S., van Hootegem, Sander J.M., Lagarde, Sjoerd M., Kingma, B. Feike, Ruurda, Jelle P., Kennedy, Raymond, Carey, P. Declan, Prodehl, Leanne, Lamb, Peter J., Skipworth, Richard J.E., Dal Cero, Mariagiulia, Pera, Manuel, Huang, Biying, Linder, Gustav, Sundbom, Magnus, Demartines, Nicolas, MS CGO, Cancer, Mantziari, Styliani, Elliott, Jessie A., Markar, Sheraz R., Klevebro, Fredrik, Goense, Lucas, Johar, Asif, Lagergren, Pernilla, Zaninotto, Giovanni, van Hillegersberg, Richard, van Berge Henegouwen, Mark I., Schäfer, Markus, Nilsson, Magnus, Hanna, George B., Reynolds, John V., Van Veer, Hans, Depypere, Lieven, Coosemans, Willy, Nafteux, Philippe, Carroll, Paul, Allison, Frances, Darling, Gail, Findlay, John M., Everden, Serenydd, Maynard, Nicholas D., Ariyarathenam, Arun, Sanders, Grant, Jaunoo, Shameen, Singh, Pritam, Parsons, Simon, Saunders, John, Vohra, Ravinder, Sinha, Aaditya, Tan, Benjamin H.L., Whiting, John G., Boshier, Piers R., Phillips, Alexander W., Griffin, S. Michael, Walker, Robert C., Underwood, Tim J., Piessen, Guillaume, Theisen, Jorg, Friess, Hans, Bruns, Christiane J., Schröder, Wolfgang, Collins, Chris G., McAnena, Oliver J., Rooney, Siobhan, Quinn, Aoife, Toale, Conor, Murphy, Thomas J., Ravi, Narayanasamy, Donohoe, Claire L., Scarpa, Marco, Bardini, Romeo, Degasperi, Silvia, Saadeh, Luca, Castoro, Carlo, Alfieri, Rita, Pinto, Eleonora, Mattara, Genny, Kalff, Marianne C., Gisbertz, Suzanne S., van Hootegem, Sander J.M., Lagarde, Sjoerd M., Kingma, B. Feike, Ruurda, Jelle P., Kennedy, Raymond, Carey, P. Declan, Prodehl, Leanne, Lamb, Peter J., Skipworth, Richard J.E., Dal Cero, Mariagiulia, Pera, Manuel, Huang, Biying, Linder, Gustav, Sundbom, Magnus, and Demartines, Nicolas

Published
2024

13. Risk Factors, Diagnosis and Management of Chyle Leak Following Esophagectomy for Cancers: An International Consensus Statement

Author

Kamarajah, Sivesh K., Siddaiah-Subramanya, Manjunath, Parente, Alessandro, Evans, Richard P. T., Adeyeye, Ademola, Ainsworth, Alan, Takahashi, Alberto M. L., Charalabopoulos, Alex, Chang, Andrew, Eroglue, Atila, Wijnhoven, Bas, Donohoe, Claire, Molena, Daniela, Talavera-Urquijo, Eider, Takeda, Flavio Roberto, Darling, Gail, Rosero, German, Piessen, Guillaume, Mahendran, Hans, Kuei, Hsu Po, Gockel, Ines, Negoi, Ionut, Weindelmayer, Jacopo, Rasanen, Jari, Bekele, Kebebe, Kim, Guowei, Depypere, Lieven, Ferri, Lorenzo, Nilsson, Magnus, Klevebro, Frederik, Smithers, B. Mark, van Berge Henegouwen, Mark I., Grimminger, Peter, Schneider, Paul M., Pramesh, C. S., Sayyed, Raza, Babor, Richard, Mine, Shinji, Law, Simon, Gisbertz, Suzanne, Bright, Tim, Benoit D’Journo, Xavier, Low, Donald, Singh, Pritam, and Griffiths, Ewen A

Published
2022
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15. Implementation of an enhanced recovery protocol for lung volume reduction surgery: an observational cohort study.

Author

Vandervelde, Christelle M, Everaerts, Stephanie, Weder, Walter, Orolé, Siebe, Hermans, Pieter-Jan, Leyn, Paul De, Nafteux, Philippe, Decaluwé, Herbert, Veer, Hans Van, Depypere, Lieven, Coppens, Steve, Neyrinck, Arne P, Bouneb, Sofian, Coster, Johan De, Coolen, Johan, Dooms, Christophe, Raemdonck, Dirk E Van, Janssens, Wim, and Ceulemans, Laurens J

Subjects
LUNG volume, FORCED expiratory volume, COHORT analysis, SURGICAL complications, POSTOPERATIVE care, CHEST tubes
Abstract

OBJECTIVES Lung volume reduction surgery (LVRS) is an established therapeutic option for advanced emphysema. To improve patients' safety and reduce complications, an enhanced recovery protocol (ERP) was implemented. This study aims to describe and evaluate the short-term outcome of this ERP. METHODS This retrospective single-centre study included all consecutive LVRS patients (1 January 2017 until 15 September 2020). An ERP for LVRS was implemented and stepwise optimised from 1 August 2019, it consisted of changes in pre-, peri- and postoperative care pathways. Patients were compared before and after implementation of ERP. Primary outcome was incidence of postoperative complications (Clavien-Dindo), and secondary outcomes included chest tube duration, incidence of prolonged air leak (PAL), length of stay (LOS) and 90-day mortality. Lung function and exercise capacity were evaluated at 3 and 6 months post-LVRS. RESULTS Seventy-six LVRS patients were included (pre-ERP: n =41, ERP: n =35). The ERP cohort presented with lower incidence of postoperative complications (42% vs 83%, P =0.0002), shorter chest tube duration (4 vs 12 days, P <0.0001) with a lower incidence of PAL (21% vs 61%, P =0.0005) and shorter LOS (6 vs 14 days, P <0.0001). No in-hospital mortality occurred in the ERP cohort versus 4 pre-ERP. Postoperative forced expiratory volume in 1 s was higher in the ERP cohort compared to pre-ERP at 3 months (1.35 vs 1.02 l) and at 6 months (1.31 vs 1.01 l). CONCLUSIONS Implementation of ERP as part of a comprehensive reconceptualisation towards LVRS, demonstrated fewer postoperative complications, including PAL, resulting in reduced LOS. Improved short-term functional outcomes were observed at 3 and 6 months. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Complications related to extracorporeal life support in lung transplantation: single-center analysis

Author

Orlitová, Michaela, primary, Goos, Wout, additional, Van Slambrouck, Jan, additional, Degezelle, Karlien, additional, Vanluyten, Cedric, additional, Vandervelde, Christelle, additional, De Beule, Julie, additional, Jin, Xin, additional, Berkmans, Evelien, additional, De Leyn, Paul, additional, Decaluwé, Herbert, additional, Van Veer, Hans, additional, Depypere, Lieven, additional, Verleden, Geert M., additional, Godinas, Laurent, additional, Vos, Robin, additional, De Troy, Erwin, additional, Dauwe, Dieter F., additional, Ingels, Catherine, additional, Meersseman, Philippe, additional, Hermans, Greet, additional, Wauters, Joost, additional, Rega, Filip, additional, Meyns, Bart, additional, Verbelen, Tom, additional, Van Raemdonck, Dirk E., additional, Neyrinck, Arne P., additional, and Ceulemans, Laurens J., additional

Published
2023
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17. Off-pump lung re-transplantation avoiding clamshell thoracotomy is feasible and safe: a single-center experience

Author

Jin, Xin, primary, Vanluyten, Cedric, additional, Orlitová, Michaela, additional, Van Slambrouck, Jan, additional, Vos, Robin, additional, Verleden, Geert M., additional, Godinas, Laurent, additional, Neyrinck, Arne P., additional, Ingels, Catherine, additional, Vanaudenaerde, Bart M., additional, De Leyn, Paul, additional, Van Veer, Hans, additional, Depypere, Lieven, additional, Zhang, Yi, additional, Van Raemdonck, Dirk E. M., additional, and Ceulemans, Laurens J., additional

Published
2023
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22. Contributors

Author

Abbas, Abbas E., primary, Adams, David B., additional, Aggarwal, Piyush, additional, Ahmed, Bestoun H., additional, Albanese, Craig, additional, Albert, Matthew R., additional, Ali, Abubaker, additional, Alicuben, Evan, additional, Allaix, Marco E., additional, Altman, Ashley, additional, Ando, Hisami, additional, Andolfi, Ciro, additional, Annamalai, Alagappan, additional, Asare, Elliot A., additional, Asti, Emanuele, additional, Auchincloss, Hugh G., additional, Babic, Benjamin, additional, Baker, Talia B., additional, Ball, Chad G., additional, Barbetta, Arianna, additional, Barlow, John M., additional, Barr, Justin, additional, Barreto, Juan Camilo, additional, Barry, Linda, additional, Beal, Eliza W., additional, Beard, Kristin Wilson, additional, Beck, David E., additional, Behrns, Kevin E., additional, Bellevue, Oliver C., additional, Bellorin-Marin, Omar E., additional, Bergman, Jacques, additional, Berry, James, additional, Besselink, Marc G.H., additional, Bharucha, Adil E., additional, Bilchik, Anton J., additional, Bildzukewicz, Nikolai A., additional, Bingham, Jason, additional, Birnbaum, Elisa, additional, Black, Sylvester M., additional, Blackmon, Shanda H., additional, Bleier, Joshua I.S., additional, Bodzin, Adam S., additional, Boland, C. Richard, additional, Bolton, John, additional, Bolton, Nathan, additional, Bonavina, Luigi, additional, Bonds, Morgan, additional, Bouwense, Stefan A.W., additional, Boys, Joshua A., additional, Bravo-Infante, Raquel, additional, Bremner, Ross M., additional, Brenner, Bruce M., additional, Brown, Shaun R., additional, Callery, Mark P., additional, Cameron, John L., additional, Camilleri, Michael, additional, Campbell, Jacob, additional, Cassim, Riaz, additional, Castillo-Angeles, Manuel, additional, Cauley, Christy, additional, Cavaness, Keith M., additional, Cerfolio, Robert J., additional, Champagne, Bradley J., additional, Chandrasoma, Parakrama, additional, Chang, Alex L., additional, Chapman, Christopher G., additional, Chapman, William C., additional, Cheek, Susannah, additional, Chen, Harvey S., additional, Cho, Clifford S., additional, Choi, Eric T., additional, Choi, Eugene A., additional, Chojnacki, Karen A., additional, Choti, Michael A., additional, Christie, Ian, additional, Chua, Heidi, additional, Church, James M., additional, Cioffi, Jessica L., additional, Clark, Susannah, additional, Clavien, Pierre-Alain, additional, Cloud, Adam, additional, Colavita, Paul D., additional, Colquhoun, Steven D., additional, Conway, William, additional, Cools-Lartigue, Jonathan, additional, Coosemans, Willy, additional, Cornwell, Edward E., additional, Costantini, Mario, additional, Coyle, Yvonne, additional, Craig, Daniel A., additional, Croome, Kristopher P., additional, Cullen, Joseph J., additional, D'Andrea, Anthony P., additional, Dassopoulos, Themistocles, additional, Davila, Marta L., additional, Davila, Raquel E., additional, DeMeester, Steven R., additional, DeMeester, Tom R., additional, Dempsey, Daniel T., additional, dePrisco, Gregory, additional, Depypere, Lieven, additional, Dietz, David W., additional, Dillhoff, Mary E., additional, DiNorcia, Joseph, additional, Doane, Stephen M., additional, Dogeas, Epameinondas, additional, Dozois, Eric J., additional, Dumon, Kristoffel, additional, Dunn, Stephen P., additional, Dunst, Christy M., additional, Dussel, John N., additional, Dyer, Matthew, additional, Efron, Jonathan, additional, El-Gohary, Yousef, additional, Lakis, Mustapha El, additional, Ellison, E. Christopher, additional, Ellsmere, James, additional, Essani, Rahila, additional, Evans, Douglas B., additional, Fang, Sandy H., additional, Fasen, Geoffrey, additional, Fernando, Hiran C., additional, Ferri, Lorenzo, additional, Fichera, Alessandro, additional, Finck, Christine, additional, Fisher, Oliver M., additional, Fleshman, James W., additional, Fong, Yuman, additional, Foreman, Michael L., additional, Francone, Todd D., additional, Franko, Edward R., additional, French, Daniel, additional, Fuchs, Hans Friedrich, additional, Fuchs, Karl Hermann, additional, Funaki, Brian, additional, Funk, Geoffrey A., additional, Fusco, Joseph, additional, Gaitonde, Shrawan G., additional, Gajjar, Aakash H., additional, Garcia-Aguilar, Julio, additional, Gearhart, Susan, additional, Geller, David A., additional, Ghobadi, Comeron, additional, Gilbert, Sebastien, additional, Giles, David, additional, Gillaspie, Erin, additional, Girotti, Micah, additional, Gittes, George K., additional, Goodman, Michael D., additional, Gooszen, Hein G., additional, Gores, Gregory J., additional, Griffin, James F., additional, Griffin, S. Michael, additional, Grimm, Leander, additional, Grochola, L.F., additional, Habib, Fahim, additional, Hanks, John B., additional, Harris, James E., additional, Hartwig, Matthew G., additional, Hassan, Imran, additional, Hedrick, Traci L., additional, Hicks, Terry C., additional, Hodin, Richard, additional, Hofstetter, Wayne L., additional, Hogg, Melissa, additional, Hu, Yue-Yung, additional, Hungness, Eric S., additional, Hunt, Steven R., additional, Huseynova, Khumara, additional, Hyman, Neil H., additional, Iannitti, David A., additional, Indes, Jeffrey, additional, Jenkins, Megan, additional, Jensen, Todd, additional, Jeziorczak, Paul M., additional, Jilani, Danial, additional, Jiménez-Toscano, Marta, additional, Jobe, Blair A., additional, Johnston, Lily E., additional, Kahrilas, Peter J., additional, Kalady, Matthew F., additional, Kassira, Noor, additional, Katkhouda, Namir, additional, Katz, Philip O., additional, Keller, Deborah S., additional, Kelley, Matthew P., additional, Kennedy, Gregory D., additional, Kent, Tara Sotsky, additional, Kia, Leila, additional, Kibbe, Melina R., additional, Kim, John, additional, King, Alice, additional, Kiran, Ravi P., additional, Kirton, Orlando C., additional, Klein, Andrew, additional, Klein, Eric N., additional, Kohn, Geoffrey P., additional, Kovell, Robert Caleb, additional, Kozol, Robert, additional, Lacy, Antonio M., additional, Ladner, Daniela P., additional, Lagarde, S.M., additional, Laituri, Carrie A., additional, Landmann, Alessandra, additional, Lee, Janet T., additional, Lee, Lawrence L., additional, Leinicke, Jennifer A., additional, Lerut, Toni, additional, Levi, David M., additional, Li, Chao, additional, Liang, Yu, additional, Lichliter, Andrew H., additional, Lichliter, Warren E., additional, Lightner, Amy L., additional, Lile, Deacon J., additional, Lillemoe, Keith D., additional, Lin, Jules, additional, Lin, Shu S., additional, Lipham, John C., additional, Litle, Virginia R., additional, Lodhia, Nayna A., additional, Longo, Walter E., additional, Lord, Reginald V.N., additional, Louie, Brian E., additional, Low, Donald E., additional, Lowe, Val J., additional, Luc, Jessica G.Y., additional, Luketich, James D., additional, Ma, Yanling, additional, MacCarty, Robert L., additional, MacDonald, Blair, additional, Madoff, Robert D., additional, Magge, Deepa, additional, Maheshwari, Anurag, additional, Mahmoud, Najjia N., additional, Mahvi, David A., additional, Mahvi, David M., additional, Mak, Grace Z., additional, Mansfield, Sara A., additional, Manzano, Maricarmen, additional, Maron, David J., additional, Mathew, Melvy S., additional, Mathis, Kellie L., additional, Matthews, Jeffrey B., additional, McFadden, David W., additional, Merchea, Amit, additional, Messaris, Evangelos, additional, Miller, Daniel L., additional, Miller, Heidi J., additional, Millis, J. Michael, additional, Mittal, Sumeet K., additional, Molena, Daniela, additional, Montgomery, Stephanie C., additional, Moore, Ryan, additional, Morgan, Katherine A., additional, Mortenson, Melinda M., additional, Mulholland, Michael W., additional, Mulvihill, Michael S., additional, Mutch, Matthew, additional, Nafteux, Philippe Robert, additional, Nagaraju, Arun, additional, Nagorney, David M., additional, Nathan, Hari, additional, Natoli, Karen R., additional, Navuluri, Rakesh, additional, Nissen, Nicholas N., additional, Nobel, Tamar B., additional, Noordman, B.J., additional, Norton, Jeffrey A., additional, Novitsky, Yuri W., additional, Nussbaum, Michael S., additional, Nyberg, Scott L., additional, Oelschlager, Brant K., additional, Oh, Daniel S., additional, Otero-Piñeiro, Ana, additional, Oto, Aytekin, additional, Pachter, H. Leon, additional, Paidas, Charles N., additional, Palazzo, Francesco, additional, Paniccia, Alessandro, additional, Papaconstantinou, Harry T., additional, Pappas, Theodore N., additional, Pappou, Emmanouil P., additional, Parikh, Manish, additional, Paruch, Jennifer L., additional, Patel, Asish D., additional, Patel, Mikin, additional, Patti, Marco G., additional, Paulson, Emily Carter, additional, Pawlik, Timothy M., additional, Payne, Isaac, additional, Pemberton, John H., additional, Pendola, Michael, additional, Perez, Alexander, additional, Pernar, Luise I.M., additional, Peters, Walter R., additional, Petrowsky, Henrik, additional, Peyre, Christian G., additional, Phillips, Alexander W., additional, Pillai, Lashmikumar, additional, Plummer, Joseph M., additional, Pointer, David T., additional, Poruk, Katherine E., additional, Posner, Mitchell C., additional, Postier, Russell, additional, Prachand, Vivek N., additional, Pritts, Timothy A., additional, Quatrino, Gregory, additional, Ranka, Sagar, additional, Rattner, David W., additional, Reavis, Kevin M., additional, Reddy, Vikram B., additional, Remzi, Feza H., additional, Ricciardi, Rocco, additional, Rice, Thomas W., additional, Richman, Aaron, additional, Rider, Paul, additional, Roberts, John Paul, additional, Roberts, Patricia L., additional, Roggin, Kevin K., additional, Roll, Garrett Richard, additional, Rona, Kais, additional, Rosen, Charles B., additional, Ross, Samuel Wade, additional, Roth, J. Scott, additional, Rushing, Amy P., additional, Safar, Bashar, additional, Saldinger, Pierre F., additional, Samakar, Kamran, additional, Sandhu, Kulmeet K., additional, Schaheen, Lara W., additional, Schirmer, Bruce, additional, Schneider, Andrew, additional, Schulick, Richard D., additional, Schwab, Ben, additional, Scurci, Stephanie, additional, Senagore, Anthony, additional, Shah, Adil A., additional, Shah, Shimul A., additional, Shames, Brian, additional, Shanmugan, Skandan, additional, Shapiro, David S., additional, Silviera, Matthew, additional, Slakey, Douglas P., additional, Sloan, Joshua, additional, Smallwood, Nathan, additional, Smith, Shane P., additional, Smithers, B. Mark, additional, Smoot, Rory L., additional, Soares, Kevin C., additional, Soffer, Edy, additional, Solomina, Julia, additional, Soper, Nathaniel J., additional, Spechler, Stuart Jon, additional, Sridhar, Praveen, additional, Steele, Scott R., additional, Sternbach, Joel M., additional, Stevenson, Christina E., additional, Strong, Scott A., additional, Sucandy, Iswanto, additional, Sundaram, Magesh, additional, Sundaresan, Sudhir, additional, Swanstrom, Lee L., additional, Sylla, Patricia, additional, Takada, Tadahiro, additional, Talbot, Ethan, additional, Tam, Vernissia, additional, Tamm, Eric P., additional, Tatarian, Talar, additional, Tavakkoli, Ali, additional, Te, Helen S., additional, Teitelbaum, Ezra N., additional, Ternent, Charles A., additional, Thompson, Jon S., additional, Thomson, Iain, additional, Thorson, Alan G., additional, Thorson, Chad M., additional, Totten, Crystal F., additional, Truty, Mark J., additional, Tsai, Susan, additional, Tseng, Jennifer, additional, Tullius, Tom, additional, Tzakis, Andreas G., additional, van Lanschot, J.J.B., additional, van Santvoort, Hjalmar C., additional, Van Veer, Hans, additional, Vega, Jorge A., additional, Velanovich, Vic, additional, Vogler, Sarah A., additional, Wang, Huamin, additional, Ward, Mark A., additional, Warner, Brad W., additional, Warner, Susanne G., additional, Watson, Thomas J., additional, Waxman, Irving, additional, Webster-Lake, Carissa, additional, Wei, Benjamin, additional, Weiser, Martin R., additional, Wells, Dennis, additional, Wells, Katerina, additional, Welton, Mark Lane, additional, Wen, Yuxiang, additional, Wendling, Mark R., additional, Wesson, Hadley K.H., additional, Wexner, Steven D., additional, White, Rebekah R., additional, Whitlow, Charles B., additional, Wijnhoven, B.P.L., additional, Wilkes, Justin, additional, Wilson, Rickesha L., additional, Witkowski, Piotr, additional, Wolfgang, Christopher L., additional, Worrell, Stephanie G., additional, Yang, Jian, additional, Yeo, Charles J., additional, Yeung, Ching, additional, Yung, Evan E., additional, Zafar, Syed Nabeel, additional, Zaninotto, Giovanni, additional, Zeh, Herbert, additional, Zehetner, Joerg, additional, Zenilman, Michael E., additional, Zimmerman, Pamela, additional, and Zuccaro, Gregory, additional

Published
2019
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25. Endovascular transatrial stenting of pulmonary vein stenosis after lung transplantation

Author

Orlitová, Michaela, primary, Gewillig, Marc, additional, Van Slambrouck, Jan, additional, Vlasselaers, Dirk, additional, Jacobs, Bart, additional, Neyrinck, Arne P., additional, Depypere, Lieven, additional, Godinas, Laurent, additional, Vos, Robin, additional, Verleden, Geert M., additional, Van Raemdonck, Dirk E., additional, and Ceulemans, Laurens J., additional

Published
2023
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27. Online Survey Evaluation of Three Years of European Society of Thoracic Surgeons Educational Webinars as Part of The E‐learning Platform

Author

Depypere, Lieven P., primary, Novoa, Nuria, additional, Daddi, Niccolò, additional, Assouad, Jalal, additional, Agrafiotis, Apostolos C., additional, Lauk, Olivia, additional, Decaluwé, Herbert, additional, Falcoz, Pierre Emmanuel, additional, Opitz, Isabelle, additional, Brunelli, Alessandro, additional, and Batirel, Hasan Fevzi, additional

Published
2022
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31. Multicentric evaluation of the impact of central tumour location when comparing rates of N1 upstaging in patients undergoing video-assisted and open surgery for clinical Stage I non-small-cell lung cancer†

Author

Decaluwé, Herbert, Petersen, René Horsleben, Brunelli, Alex, Pompili, Cecilia, Seguin-Givelet, Agathe, Gust, Lucile, Aigner, Clemens, Falcoz, Pierre-Emmanuel, Rinieri, Philippe, Augustin, Florian, Sokolow, Youri, Verhagen, Ad, Depypere, Lieven, Papagiannopoulos, Kostas, Gossot, Dominique, D’Journo, Xavier Benoit, Guerrera, Francesco, Baste, Jean-Marc, Schmid, Thomas, Stanzi, Alessia, Van Raemdonck, Dirk, Bardet, Jeremy, Thomas, Pascal-Alexandre, Massard, Gilbert, Fieuws, Steffen, Moons, Johnny, Dooms, Christophe, De Leyn, Paul, and Hansen, Henrik Jessen

Published
2018
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33. Lung transplant outcome following donation after euthanasia

Author

Ceulemans, Laurens J., primary, Vanluyten, Cedric, additional, Monbaliu, Diethard, additional, Schotsmans, Paul, additional, Fieuws, Steffen, additional, Vandervelde, Christelle M., additional, De Leyn, Paul, additional, Decaluwé, Herbert, additional, Van Veer, Hans, additional, Depypere, Lieven, additional, Van Slambrouck, Jan, additional, Gunst, Jan, additional, Vanaudenaerde, Bart M., additional, Godinas, Laurent, additional, Dupont, Lieven, additional, Vos, Robin, additional, Verleden, Geert M., additional, Neyrinck, Arne P., additional, and Van Raemdonck, Dirk, additional

Published
2022
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34. Risk Factors, Diagnosis and Management of Chyle Leak Following Esophagectomy for Cancers:An International Consensus Statement

Author

Kamarajah, Sivesh K, Siddaiah-Subramanya, Manjunath, Parente, Alessandro, Evans, Richard P T, Adeyeye, Ademola, Ainsworth, Alan, Takahashi, Alberto M L, Charalabopoulos, Alex, Chang, Andrew, Eroglue, Atila, Wijnhoven, Bas, Donohoe, Claire, Molena, Daniela, Talavera-Urquijo, Eider, Takeda, Flavio Roberto, Darling, Gail, Rosero, German, Piessen, Guillaume, Mahendran, Hans, Kuei, Hsu Po, Gockel, Ines, Negoi, Ionut, Weindelmayer, Jacopo, Rasanen, Jari, Bekele, Kebebe, Kim, Guowei, Depypere, Lieven, Ferri, Lorenzo, Nilsson, Magnus, Klevebro, Frederik, Smithers, B Mark, van Berge Henegouwen, Mark I, Grimminger, Peter, Schneider, Paul M, Pramesh, C S, Sayyed, Raza, Babor, Richard, Mine, Shinji, Law, Simon, Gisbertz, Suzanne, Bright, Tim, Benoit D'Journo, Xavier, Low, Donald, Singh, Pritam, Griffiths, Ewen A, Kamarajah, Sivesh K, Siddaiah-Subramanya, Manjunath, Parente, Alessandro, Evans, Richard P T, Adeyeye, Ademola, Ainsworth, Alan, Takahashi, Alberto M L, Charalabopoulos, Alex, Chang, Andrew, Eroglue, Atila, Wijnhoven, Bas, Donohoe, Claire, Molena, Daniela, Talavera-Urquijo, Eider, Takeda, Flavio Roberto, Darling, Gail, Rosero, German, Piessen, Guillaume, Mahendran, Hans, Kuei, Hsu Po, Gockel, Ines, Negoi, Ionut, Weindelmayer, Jacopo, Rasanen, Jari, Bekele, Kebebe, Kim, Guowei, Depypere, Lieven, Ferri, Lorenzo, Nilsson, Magnus, Klevebro, Frederik, Smithers, B Mark, van Berge Henegouwen, Mark I, Grimminger, Peter, Schneider, Paul M, Pramesh, C S, Sayyed, Raza, Babor, Richard, Mine, Shinji, Law, Simon, Gisbertz, Suzanne, Bright, Tim, Benoit D'Journo, Xavier, Low, Donald, Singh, Pritam, and Griffiths, Ewen A

Abstract

UNLABELLED: This Delphi exercise aimed to gather consensus surrounding risk factors, diagnosis, and management of chyle leaks after esophagectomy and to develop recommendations for clinical practice.BACKGROUND: Chyle leaks following esophagectomy for malignancy are uncommon. Although they are associated with increased morbidity and mortality, diagnosis and management of these patients remain controversial and a challenge globally.METHODS: This was a modified Delphi exercise was delivered to clinicians across the oesophagogastric anastomosis collaborative. A 5-staged iterative process was used to gather consensus on clinical practice, including a scoping systematic review (stage 1), 2 rounds of anonymous electronic voting (stages 2 and 3), data-based analysis (stage 4), and guideline and consensus development (stage 5). Stratified analyses were performed by surgeon specialty and surgeon volume.RESULTS: In stage 1, the steering committee proposed areas of uncertainty across 5 domains: risk factors, intraoperative techniques, and postoperative management (ie, diagnosis, severity, and treatment). In stages 2 and 3, 275 and 250 respondents respectively participated in online voting. Consensus was achieved on intraoperative thoracic duct ligation, postoperative diagnosis by milky chest drain output and biochemical testing with triglycerides and chylomicrons, assessing severity with volume of chest drain over 24 hours and a step-up approach in the management of chyle leaks. Stratified analyses demonstrated consistent results. In stage 4, data from the Oesophagogastric Anastomosis Audit demonstrated that chyle leaks occurred in 5.4% (122/2247). Increasing chyle leak grades were associated with higher rates of pulmonary complications, return to theater, prolonged length of stay, and 90-day mortality. In stage 5, 41 surgeons developed a set of recommendations in the intraoperative techniques, diagnosis, and management of chyle leaks.CONCLUSIONS

Published
2022

35. Real-life introduction of powered circular stapler for esophagogastric anastomosis: cohort and propensity matched score study.

Author

Vanstraelen, Stijn, Coosemans, Willy, Depypere, Lieven, Mandeville, Yannick, Moons, Johnny, Veer, Hans Van, and Nafteux, Philippe

Subjects
PROPENSITY score matching, STAPLERS (Surgery), SURGICAL complications, BODY mass index, ESOPHAGEAL cancer, NEOADJUVANT chemotherapy
Abstract

Anastomotic leakage after esophagectomy is one of the most feared complications, which results in increased morbidity and mortality. Our aim was to evaluate the impact of a powered circular stapler on complications after esophagectomy with intrathoracic anastomosis for esophageal cancer. Between May 2019 and July 2021, all consecutive oesophagectomies for cancer with intrathoracic anastomosis in a high-volume center were included in this retrospective study. Surgeons were free to choose either a manual or a powered circular stapler. Preoperative characteristics and postoperative complications were recorded in a prospective database, according to EsoData. Propensity score matching (age, body mass index, Eastern cooperative oncology group (ECOG) performance and neoadjuvant therapy) was conducted to reduce potential confounding. We included 128 patients. Powered and manual circular staplers were used in 62 and 66 patients, respectively. Fewer anastomotic leakages were observed with the powered stapler group (OR = 7.3 (95%CI: 1.58–33.7); [3.2% (n  = 2) vs 19.7% (n  = 13), respectively; p  = 0.004]). After propensity score matching, this remained statistically significant (OR = 8.5 (95%CI: 1.80–40.1); [4.1% (n  = 2) vs 20.4% (n  = 10), respectively; p  = 0.013]). Additionally, anastomotic diameter was significantly higher with the powered stapler (median: 29 mm (63.3%) vs 25 mm (57.1%), respectively; p  < 0.0001). There was no significant difference in comprehensive complication index (p  = 0.146). A decreased mean length of stay was observed in the powered stapler group (11.1 vs 18.7 days respectively; p  = 0.022). Postoperative anastomotic leakage after esophageal resection was significantly reduced after the introduction of the powered circular stapler, consequently resulting in a reduced length of stay. Further evaluation on long-term strictures and quality of life are warranted to support these results. [ABSTRACT FROM AUTHOR]

Published
2023
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37. Neoadjuvant camrelizumab plus chemotherapy for resectable, locally advanced esophageal squamous cell carcinoma ( NIC‐ESCC2019 ): A multicenter, phase 2 study

Author

Liu, Jun, primary, Li, Jingpei, additional, Lin, Wanli, additional, Shao, Di, additional, Depypere, Lieven, additional, Zhang, Zhifeng, additional, Li, Zhuoyi, additional, Cui, Fei, additional, Du, Zesen, additional, Zeng, Yuan, additional, Jiang, Shunjun, additional, He, Ping, additional, Gu, Xia, additional, Chen, Huai, additional, Zhang, Hai, additional, Lin, Xiaowei, additional, Huang, Haoda, additional, Lv, Wenqiang, additional, Cai, Weiming, additional, Liang, Wenhua, additional, Liang, Hengrui, additional, Jiang, Wenxi, additional, Wang, Wei, additional, Xu, Ke, additional, Cai, Weipeng, additional, Wu, Kui, additional, Lerut, Toni, additional, Fu, Junhui, additional, and He, Jianxing, additional

Published
2022
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46. Successful double-lung transplantation from a donor previously infected with SARS-CoV-2

Author

Ceulemans, Laurens J, primary, Van Slambrouck, Jan, additional, De Leyn, Paul, additional, Decaluwé, Herbert, additional, Van Veer, Hans, additional, Depypere, Lieven, additional, Ceuterick, Vincent, additional, Verleden, Stijn E, additional, Vanstapel, Arno, additional, Desmet, Stefanie, additional, Maes, Piet, additional, Van Ranst, Marc, additional, Lormans, Piet, additional, Meyfroidt, Geert, additional, Neyrinck, Arne P, additional, Vanaudenaerde, Bart M, additional, Van Wijngaerden, Eric, additional, Bos, Saskia, additional, Godinas, Laurent, additional, Carmeliet, Peter, additional, Verleden, Geert M, additional, Van Raemdonck, Dirk E, additional, and Vos, Robin, additional

Published
2021
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47. Histopathologic and radiologic assessment of nontransplanted donor lungs

Author

Vanstapel, Arno, Dubbeldam, Adriana, Weynand, Birgit, Verbeken, Eric K, Vos, Robin, Neyrinck, Arne P, Vasilescu, Dragos M, Ceulemans, Laurens J, Frick, Anna E, Van Raemdonck, Dirk E, Verschakelen, Johny, Vanaudenaerde, Bart M, Verleden, Geert M, Verleden, Stijn E, Dupont, Lieven J, Yserbyt, Jonas, Godinas, Laurent, Van Herck, Anke, Sacreas, Annelore, Kaes, Janne, Heigl, Tobias, Ordies, Sofie, Schaevers, Veronique, De Leyn, Paul, Coosemans, Willy, Nafteux, Philippe, Decaluwe, Herbert, Van Veer, Hans, Depypere, Lieven, Emonds, Marie-Paule, and Leuven Lung Transplant Grp

Subjects
medicine.medical_specialty, Tissue and Organ Procurement, Bronchoscopy, Organ acceptance, medicine, Humans, Immunology and Allergy, Pharmacology (medical), Lung, Leuven Lung Transplant Group, Transplantation, medicine.diagnostic_test, business.industry, Histology, respiratory system, medicine.disease, Tissue Donors, Donor lungs, respiratory tract diseases, medicine.anatomical_structure, Histopathology, Radiology, Human medicine, Tomography, X-Ray Computed, business, Pneumonia (non-human), Lung Transplantation
Abstract

Donor organ shortage results in significant waiting list mortality. Donor lung assessment is currently based on donors' history, gas exchange, chest X-ray, bronchoscopy findings, and ultimately in situ inspection but remains subjective. We correlated histopathology and radiology in nontransplanted donor lungs with the clinical indications to decline the offered organ. Sixty-two donor lungs, not used for transplantation (2010-2019), were procured, air-inflated, frozen, scanned with computed tomography, systematically sampled, and histologically and radiologically assessed. Thirty-nine (63%) lungs were declined for allograft-related reasons. In 13/39 (33%) lungs, histology could not confirm the reason for decline, in an additional 8/39 (21%) lungs, histologic abnormalities were only considered mild. In 16/39 (41%) lungs, radiology could not confirm the reason for decline. Twenty-three (37%) donor lungs were not transplanted due to extrapulmonary causes, of which three (13%) lungs displayed severe histologic abnormalities (pneumonia, n = 2; emphysema, n = 1), in addition to mild emphysema in 9 (39%) lungs and minor bronchopneumonia in 1 (4%). Radiology revealed ground-glass opacities in 8/23 (35%) and emphysema in 4/23 (17%) lungs. Histopathologic and radiologic assessment of nontransplanted donor lungs revealed substantial discrepancy with the clinical reason for decline. Optimization of donor lung assessment is necessary to improve current organ acceptance rates. ispartof: AMERICAN JOURNAL OF TRANSPLANTATION vol:20 issue:6 pages:1712-1719 ispartof: location:United States status: published

Published
2020

48. Identification and characterization of chronic lung allograft dysfunction patients with mixed phenotype: A single-center study

Author

Verleden, Stijn E, Von Der Thusen, Jan, Van Herck, Anke, Weynand, Birgit, Verbeken, Erik, Verschakelen, Johny, Dubbeldam, Adriana, Vanaudenaerde, Bart M, Vos, Robin, Verleden, Geert M, Dupont, Lieven J, Yserbyt, Jonas, Godinas, Laurent, Vanstapel, Arno, Sacreas, Annelore, Kaes, Janne, Heigl, Tobias, Ordies, Sofie, Neyrinck, Arne P, Schaevers, Veronique, De Leyn, Paul, Van Raemdonck, Dirk E, Coosemans, Willy, Nafteux, Philippe, Decaluwe, Herbert, Van Veer, Hans, Depypere, Lieven, Frick, Anna E, Ceulemans, Laurens J, and Leuven Lung Transplant Grp

Subjects
medicine.medical_specialty, medicine.medical_treatment, Bronchiolitis obliterans, bronchiolitis obliterans syndrome, 030230 surgery, Single Center, Gastroenterology, Pulmonary function testing, 03 medical and health sciences, FEV1/FVC ratio, 0302 clinical medicine, Internal medicine, Medicine, Lung transplantation, Humans, restrictive allograft syndrome, Bronchiolitis Obliterans, Lung, chronic lung allograft dysfunction, Transplantation, mixed CLAD, business.industry, phenotypes, medicine.disease, Allografts, Phenotype, medicine.anatomical_structure, Chronic Disease, 030211 gastroenterology & hepatology, Histopathology, Human medicine, Primary Graft Dysfunction, business, Lung Transplantation
Abstract

RATIONALE: Patients can change chronic lung allograft dysfunction (CLAD) phenotype, especially from BOS to mixed phenotype. Our aim was to further characterize these patients. METHOD: Mixed CLAD was defined as a restrictive physiology with persistent CT opacities, after initial bronchiolitis obliterans syndrome (BOS) diagnosis. The incidence, prognosis, pulmonary function, radiology, pathology, and airway inflammation were compared between patients with restrictive allograft syndrome (RAS) and mixed CLAD. RESULT: A total of 268 (44%) patients developed CLAD of which 47 (18%) were diagnosed with RAS "ab initio," 215 (80%) with BOS, and 6 (2%) an undefined phenotype. Twenty-five patients developed a mixed CLAD phenotype (24 BOS to mixed and 1 RAS to mixed). Survival after mixed phenotype diagnosis was comparable (P = .39) to RAS. More emphysema patients developed a mixed phenotype (P = .020) compared to RAS ab initio, while mixed CLAD patients had a lower FEV1 (P

Published
2020

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