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307 results on '"Depuydt, Tom"'

1. Urethral and bladder dose–effect relations for late genitourinary toxicity following external beam radiotherapy for prostate cancer in the FLAME trial

Author

Groen, Veerle H., van Schie, Marcel, Zuithoff, Nicolaas P.A., Monninkhof, Evelyn M., Kunze-Busch, Martina, de Boer, Johannes C.J., van der Voort van Zijp, Jochem, Pos, Floris J., Smeenk, Robert Jan, Haustermans, Karin, Isebaert, Sofie, Draulans, Cédric, Depuydt, Tom, Verkooijen, Helena M., van der Heide, Uulke A., and Kerkmeijer, Linda G.W.

Published
2022
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2. Electrochemical Degradation of Molecularly Imprinted Polymers for Future Applications of Inflammation Sensing in Cochlear Implants

Author

Nguyen, Minh-Hai, primary, Onken, Adrian, additional, Sündermann, Jan, additional, Shamsuyeva, Madina, additional, Singla, Pankaj, additional, Depuydt, Tom, additional, Peeters, Marloes, additional, Wagner, Patrick, additional, Bethmann, Konrad, additional, Körner, Julia, additional, Endres, Hans-Josef, additional, Lenarz, Thomas, additional, and Doll, Theodor, additional

Published
2024
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4. Anorectal dose–effect relations for late gastrointestinal toxicity following external beam radiotherapy for prostate cancer in the FLAME trial

Author

Groen, Veerle H., Zuithoff, Nicolaas P.A., van Schie, Marcel, Monninkhof, Evelyn M., Kunze-Busch, Martina, de Boer, Hans C.J., van der Voort van Zyp, Jochem, Pos, Floris J., Smeenk, Robert Jan, Haustermans, Karin, Isebaert, Sofie, Draulans, Cédric, Depuydt, Tom, Verkooijen, Helena M., van der Heide, Uulke A., and Kerkmeijer, Linda G.W.

Published
2021
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8. Clinical Implementation of DeepVoxNet for Auto-Delineation of Organs at Risk in Head and Neck Cancer Patients in Radiotherapy

Author

Willems, Siri, Crijns, Wouter, La Greca Saint-Esteven, Agustina, Van Der Veen, Julie, Robben, David, Depuydt, Tom, Nuyts, Sandra, Haustermans, Karin, Maes, Frederik, Hutchison, David, Series Editor, Kanade, Takeo, Series Editor, Kittler, Josef, Series Editor, Kleinberg, Jon M., Series Editor, Mattern, Friedemann, Series Editor, Mitchell, John C., Series Editor, Naor, Moni, Series Editor, Pandu Rangan, C., Series Editor, Steffen, Bernhard, Series Editor, Terzopoulos, Demetri, Series Editor, Tygar, Doug, Series Editor, Weikum, Gerhard, Series Editor, Stoyanov, Danail, editor, Taylor, Zeike, editor, Sarikaya, Duygu, editor, McLeod, Jonathan, editor, González Ballester, Miguel Angel, editor, Codella, Noel C.F., editor, Martel, Anne, editor, Maier-Hein, Lena, editor, Malpani, Anand, editor, Zenati, Marco A., editor, De Ribaupierre, Sandrine, editor, Xiongbiao, Luo, editor, Collins, Toby, editor, Reichl, Tobias, editor, Drechsler, Klaus, editor, Erdt, Marius, editor, Linguraru, Marius George, editor, Oyarzun Laura, Cristina, editor, Shekhar, Raj, editor, Wesarg, Stefan, editor, Celebi, M. Emre, editor, Dana, Kristin, editor, and Halpern, Allan, editor

Published
2018
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12. Challenges and opportunities for proton therapy during pregnancy.

Author

Blommaert, Jeroen, De Saint‐Hubert, Marijke, Depuydt, Tom, Oldehinkel, Edwin, Poortmans, Philip, Amant, Frederic, and Lambrecht, Maarten

Subjects
PROTON therapy, PREGNANT women, CANCER radiotherapy, PREGNANCY, RADIATION doses
Abstract

During pregnancy, the use of radiation therapy for cancer treatment is often considered impossible due to the assumed associated fetal risks. However, suboptimal treatment of pregnant cancer patients and unjustifiable delay in radiation therapy until after delivery can be harmful for both patient and child. In non‐pregnant patients, proton‐radiation therapy is increasingly administered because of its favorable dosimetric properties compared with photon‐radiation therapy. Although data on the use of pencil beam scanning proton‐radiation therapy during pregnancy are scarce, different case reports and dosimetric studies have indicated a more than 10‐fold reduction in fetal radiation exposure compared with photon‐radiation therapy. Nonetheless, the implementation of proton‐radiation therapy during pregnancy requires complex fetal dosimetry for the neutron‐dominated out‐of‐field radiation dose and faces a lack of clinical guidelines. Further exploration and standardization of proton‐radiation therapy during pregnancy will be necessary to improve radiotherapeutic management of pregnant women with cancer and further reduce risks for their offspring. [ABSTRACT FROM AUTHOR]

Published
2024
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19. The TRENDY multi-center randomized trial on hepatocellular carcinoma – Trial QA including automated treatment planning and benchmark-case results

Author

Habraken, Steven J.M., Sharfo, Abdul Wahab M., Buijsen, Jeroen, Verbakel, Wilko F.A.R., Haasbeek, Cornelis J.A., Öllers, Michel C., Westerveld, Henrike, van Wieringen, Niek, Reerink, Onne, Seravalli, Enrica, Braam, Pètra M., Wendling, Markus, Lacornerie, Thomas, Mirabel, Xavier, Weytjens, Reinhilde, Depuydt, Lieselotte, Tanadini-Lang, Stephanie, Riesterer, Oliver, Haustermans, Karin, Depuydt, Tom, Dwarkasing, Roy S., Willemssen, François E.J.A., Heijmen, Ben J.M., and Méndez Romero, Alejandra

Published
2017
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23. Experimental investigation of dynamic real‐time rotation‐including dose reconstruction during prostate tracking radiotherapy

Author

Muurholm, Casper Gammelmark, Ravkilde, Thomas, De Roover, Robin, Skouboe, Simon, Hansen, Rune, Crijns, Wouter, Depuydt, Tom, and Poulsen, Per R

Subjects
Male, BODY RADIATION-THERAPY, ARC THERAPY, ONLINE, VALIDATION, TREATMENT-COUCH, intrafraction motion management, couch tracking, IMPLEMENTATION, Humans, Radiometry, COLLIMATOR TRACKING, Science & Technology, real-time online dose reconstruction, Phantoms, Imaging, Radiotherapy Planning, Computer-Assisted, Radiology, Nuclear Medicine & Medical Imaging, Prostate, Prostatic Neoplasms, six degree of freedom motion, Radiotherapy Dosage, General Medicine, prostate cancer, INTENSITY-MODULATED RADIOTHERAPY, DOSIMETRIC IMPACT, INTRAFRACTION MOTION, MLC tracking, Radiotherapy, Intensity-Modulated, Life Sciences & Biomedicine
Abstract

BACKGROUND: Hypofractionation in prostate radiotherapy is of increasing interest. Steep dose gradients and a large weight on each individual fraction emphasize the need for motion management. Real-time motion management techniques such as multileaf collimator (MLC) tracking or couch tracking typically adjust for translational motion while rotations remain uncompensated with unknown dosimetric impact. PURPOSE: The purpose of this study is to demonstrate and validate dynamic real-time rotation-including dose reconstruction during radiotherapy experiments with and without MLC and couch tracking. METHODS: Real-time dose reconstruction was performed using the in-house developed software DoseTracker. DoseTracker receives streamed target positions and accelerator parameters during treatment delivery and uses a pencil beam algorithm with water density assumption to reconstruct the dose in a moving target. DoseTracker's ability to reconstruct motion-induced dose errors in a dynamically rotating and translating target was investigated during three different scenarios: (1) no motion compensation and translational motion correction with (2) MLC tracking and (3) couch tracking. In each scenario, dose reconstruction was performed online and in real time during delivery of two dual-arc volumetric-modulated arc therapy prostate plans with a prescribed fraction dose of 7 Gy to the prostate and simultaneous intraprostatic lesion boosts with doses of at least 8 Gy, but up to 10 Gy as long as the organs at risk dose constraints were fulfilled. The plans were delivered to a pelvis phantom that replicated three patient-measured motion traces using a rotational insert with 21 layers of EBT3 film spaced 2.5 mm apart. DoseTracker repeatedly calculated the actual motion-including dose increment and the planned static dose increment since the last calculation in 84 500 points in the film stack. The experiments were performed with a TrueBeam accelerator with MLC and couch tracking based on electromagnetic transponders embedded in the film stack. The motion-induced dose error was quantified as the difference between the final cumulative dose with motion and without motion using the 2D 2%/2 mm γ-failure rate and the difference in dose to 95% of the clinical target volume (CTV ΔD95% ) and the gross target volume (GTV ΔD95% ) as well as the difference in dose to 0.1 cm3 of the urethra, bladder, and rectum (ΔD0.1CC ). The motion-induced errors were compared between dose reconstructions and film measurements. RESULTS: The dose was reconstructed in all calculation points at a mean frequency of 4.7 Hz. The root-mean-square difference between real-time reconstructed and film-measured motion-induced errors was 3.1%-points (γ-failure rate), 0.13 Gy (CTV ΔD95% ), 0.23 Gy (GTV ΔD95% ), 0.19 Gy (urethra ΔD0.1CC ), 0.09 Gy (bladder ΔD0.1CC ), and 0.07 Gy (rectum ΔD0.1CC ). CONCLUSIONS: In a series of phantom experiments, online real-time rotation-including dose reconstruction was performed for the first time. The calculated motion-induced errors agreed well with film measurements. The dose reconstruction provides a valuable tool for monitoring dose delivery and investigating the efficacy of advanced motion-compensation techniques in the presence of translational and rotational motion. ispartof: MEDICAL PHYSICS vol:49 issue:6 pages:3574-3584 ispartof: location:United States status: published

Published
2022
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30. Proton therapy of a pregnant patient with nasopharyngeal carcinoma

Author

Heimovaara, Joosje H., primary, Blommaert, Jeroen, additional, Free, Jeffrey, additional, Bolt, René A., additional, Gort, Elske M., additional, Depuydt, Tom, additional, Boso Martinez, Cristina, additional, Schoots, Mirthe H., additional, van Gerwen, Mathilde, additional, van den Heuvel-Eibrink, Marry, additional, Langendijk, Johannes A., additional, Schröder, Carolien P., additional, Amant, Frédéric, additional, Gordijn, Sanne J., additional, and Oldehinkel, Edwin, additional

Published
2022
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34. Urethral and bladder dose-effect relations for late genitourinary toxicity following external beam radiotherapy for prostate cancer in the FLAME trial

Author

Trialbureau Beeld, Cancer, MS Radiotherapie, Biostatistiek Onderzoek, Other research (not in main researchprogram), Epi Kanker Team C, JC onderzoeksprogramma Kanker, Groen, Veerle H, van Schie, Marcel, Zuithoff, Nicolaas P A, Monninkhof, Evelyn M, Kunze-Busch, Martina, de Boer, Johannes C J, van der Voort van Zijp, Jochem, Pos, Floris J, Smeenk, Robert Jan, Haustermans, Karin, Isebaert, Sofie, Draulans, Cédric, Depuydt, Tom, Verkooijen, Helena M, van der Heide, Uulke A, Kerkmeijer, Linda G W, Trialbureau Beeld, Cancer, MS Radiotherapie, Biostatistiek Onderzoek, Other research (not in main researchprogram), Epi Kanker Team C, JC onderzoeksprogramma Kanker, Groen, Veerle H, van Schie, Marcel, Zuithoff, Nicolaas P A, Monninkhof, Evelyn M, Kunze-Busch, Martina, de Boer, Johannes C J, van der Voort van Zijp, Jochem, Pos, Floris J, Smeenk, Robert Jan, Haustermans, Karin, Isebaert, Sofie, Draulans, Cédric, Depuydt, Tom, Verkooijen, Helena M, van der Heide, Uulke A, and Kerkmeijer, Linda G W

Published
2022

39. Anorectal dose–effect relations for late gastrointestinal toxicity following external beam radiotherapy for prostate cancer in the FLAME trial

Author

Trialbureau Beeld, Cancer, Biostatistiek Onderzoek, Other research (not in main researchprogram), MS Radiotherapie, Epi Kanker Team C, JC onderzoeksprogramma Kanker, Klinische Fysica RT, Divisie Beeld, Groen, Veerle H., Zuithoff, Nicolaas P.A., van Schie, Marcel, Monninkhof, Evelyn M., Kunze-Busch, Martina, de Boer, Hans C.J., van der Voort van Zyp, Jochem, Pos, Floris J., Smeenk, Robert Jan, Haustermans, Karin, Isebaert, Sofie, Draulans, Cédric, Depuydt, Tom, Verkooijen, Helena M., van der Heide, Uulke A., Kerkmeijer, Linda G.W., Trialbureau Beeld, Cancer, Biostatistiek Onderzoek, Other research (not in main researchprogram), MS Radiotherapie, Epi Kanker Team C, JC onderzoeksprogramma Kanker, Klinische Fysica RT, Divisie Beeld, Groen, Veerle H., Zuithoff, Nicolaas P.A., van Schie, Marcel, Monninkhof, Evelyn M., Kunze-Busch, Martina, de Boer, Hans C.J., van der Voort van Zyp, Jochem, Pos, Floris J., Smeenk, Robert Jan, Haustermans, Karin, Isebaert, Sofie, Draulans, Cédric, Depuydt, Tom, Verkooijen, Helena M., van der Heide, Uulke A., and Kerkmeijer, Linda G.W.

Published
2021

40. openPR — A computational tool for CT conversion assessment with proton radiography

Author

UCL - SST/ICTM/ELEN - Pôle en ingénierie électrique, Deffet, Sylvain, Cohilis, Marie, Souris, Kevin, Salvo, Koen, Depuydt, Tom, Sterpin, Edmond, Macq, Benoit, UCL - SST/ICTM/ELEN - Pôle en ingénierie électrique, Deffet, Sylvain, Cohilis, Marie, Souris, Kevin, Salvo, Koen, Depuydt, Tom, Sterpin, Edmond, and Macq, Benoit

Abstract

Purpose: One of the main sources of uncertainty in proton therapy is the conversion of the Hounsfield Units of the planning CT to (relative) proton stopping powers. Proton radiography provides range error maps but these can be affected by other sources of errors as well as the CT conversion (e.g., residual misalignment). To better understand and quantify range uncertainty, it is desirable to measure the individual contributions and particularly those associated to the CT conversion. Methods: A workflow is proposed to carry out an assessment of the CT conversion solely on the basis of proton radiographs of real tissues measured with a multilayer ionization chamber (MLIC). The workflow consists of a series of four stages: (a) CT and proton radiography acquisitions, (b) CT and proton radiography registration in postprocessing, (c) sample‐specific validation of the semi‐empirical model both used in the registration and to estimate the water equivalent path length (WEPL), and (d) WEPL error estimation. The workflow was applied to a pig head as part of the validation of the CT calibration of the proton therapy center PARTICLE at UZ Leuven, Belgium. Results: The CT conversion‐related uncertainty computed based on the well‐established safety margin rule of 1.2 mm + 2.4% were overestimated by 71% on the pig head. However, the range uncertainty was very much underestimated where cavities were encountered by the protons. Excluding areas with cavities, the overestimation of the uncertainty was 500%. A correlation was found between these localized errors and HUs between −1000 and −950, suggesting that the underestimation was not a consequence of an inaccurate conversion but was probably rather due to the resolution of the CT leading to material mixing at interfaces. To reduce these errors, the CT calibration curve was adapted by increasing the HU interval corresponding to the air up to −950. Conclusion: The application of the workflow as part of the validation of the CT conversi

Published
2020

41. Primary endpoint analysis of the multicentre phase II hypo-FLAME trial for intermediate and high risk prostate cancer

Author

MS Radiotherapie, Cancer, Klinische Fysica RT, Trialbureau Beeld, Epi Kanker Team A, JC onderzoeksprogramma Kanker, Draulans, Cédric, van der Heide, Uulke A, Haustermans, Karin, Pos, Floris J, van der Voort van Zyp, Jochem, De Boer, Hans, Groen, Veerle H, Monninkhof, Evelyn M, Smeenk, Robert J, Kunze-Busch, Martina, De Roover, Robin, Depuydt, Tom, Isebaert, Sofie, Kerkmeijer, Linda G W, MS Radiotherapie, Cancer, Klinische Fysica RT, Trialbureau Beeld, Epi Kanker Team A, JC onderzoeksprogramma Kanker, Draulans, Cédric, van der Heide, Uulke A, Haustermans, Karin, Pos, Floris J, van der Voort van Zyp, Jochem, De Boer, Hans, Groen, Veerle H, Monninkhof, Evelyn M, Smeenk, Robert J, Kunze-Busch, Martina, De Roover, Robin, Depuydt, Tom, Isebaert, Sofie, and Kerkmeijer, Linda G W

Published
2020

48. Stereotactic body radiation therapy with optional focal lesion ablative microboost in prostate cancer: Topical review and multicenter consensus

Author

Klinische Fysica RT, Cancer, MS Radiotherapie, Draulans, Cédric, De Roover, Robin, van der Heide, Uulke A., Haustermans, Karin, Pos, Floris, Smeenk, Robert Jan, De Boer, Hans, Depuydt, Tom, Kunze-Busch, Martina, Isebaert, Sofie, Kerkmeijer, Linda, Klinische Fysica RT, Cancer, MS Radiotherapie, Draulans, Cédric, De Roover, Robin, van der Heide, Uulke A., Haustermans, Karin, Pos, Floris, Smeenk, Robert Jan, De Boer, Hans, Depuydt, Tom, Kunze-Busch, Martina, Isebaert, Sofie, and Kerkmeijer, Linda

Published
2019

49. Planning feasibility of extremely hypofractionated prostate radiotherapy on a 1.5 T magnetic resonance imaging guided linear accelerator

Author

Arts-assistenten Radiotherapie, Cancer, Klinische Fysica RT, MS Radiotherapie, Experimentele klinische fysica, den Hartogh, Mariska D., de Boer, Hans C.J., de Groot-van Breugel, Eline N., van der Voort van Zyp, Jochem R.N., Hes, Jochem, van der Heide, Uulke A., Pos, Floris, Haustermans, Karin, Depuydt, Tom, Jan Smeenk, Robert, Kunze-Busch, Martina, Raaymakers, Bas W., Kerkmeijer, Linda G.W., Arts-assistenten Radiotherapie, Cancer, Klinische Fysica RT, MS Radiotherapie, Experimentele klinische fysica, den Hartogh, Mariska D., de Boer, Hans C.J., de Groot-van Breugel, Eline N., van der Voort van Zyp, Jochem R.N., Hes, Jochem, van der Heide, Uulke A., Pos, Floris, Haustermans, Karin, Depuydt, Tom, Jan Smeenk, Robert, Kunze-Busch, Martina, Raaymakers, Bas W., and Kerkmeijer, Linda G.W.

Published
2019

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