1. Elevated allostatic load is associated with poorer response to repetitive transcranial magnetic stimulation in treatment-resistant depression.
- Author
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Longpré-Poirier C, Miron JP, Garel N, Samson-Daoust E, Rizkallah E, Desbeaumes Jodoin V, Juster RP, and Lespérance P
- Subjects
- Humans, Female, Male, Adult, Middle Aged, Treatment Outcome, Cohort Studies, Biomarkers blood, Transcranial Magnetic Stimulation, Depressive Disorder, Treatment-Resistant therapy, Depressive Disorder, Treatment-Resistant blood, Depressive Disorder, Treatment-Resistant physiopathology, Allostasis physiology
- Abstract
This cohort study investigated whether allostatic load (AL) is associated with treatment response to repetitive transcranial magnetic stimulation (rTMS) in treatment-resistant depression (TRD). Pre-treatment blood samples measured AL across multiple systems. Pre- and post-treatment mood changes were assessed using the Montgomery-Åsberg Depression Rating Scale (MADRS). Associations between AL and treatment outcomes were explored. Higher pre-treatment AL was significantly associated with poorer post-treatment response status but was not significantly associated with smaller reduction in MADRS score after 4 weeks of treatment. Identifying biomarker profiles informed by the AL model could enhance treatment decisions in TRD, reducing risks associated with prolonged, ineffective rTMS trials and emphasizing the need for reliable predictive biomarkers., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)
- Published
- 2024
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