1. Roadmap for metal nanoparticles in radiation therapy: current status, translational challenges, and future directions
- Author
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Karl T. Butterworth, Yaser Hadi Gholami, Kyle Bromma, Vincent Favaudon, Zdenka Kuncic, Jason R. Cook, Udoka Ibeh, Stéphane Lucas, Stephen J. McMahon, E. Gargioni, Sandrine Lacombe, Kevin M. Prise, Anne-Catherine Heuskin, Léon Sanche, Yaroslav Stanishevskiy, Olivier Tillement, Bijay Singh, Henry M. Smilowitz, Sang Hyun Cho, J Donald Payne, Needa A. Virani, Erika Porcel, Ross Berbeco, Wonmo Sung, Félicien Hespeels, Benedikt Rudek, Dmitry Nevozhay, Wassana Yantasee, Hans Rabus, Devika B. Chithrani, Wilfred Ngwa, Sébastien Penninckx, François Lux, Konstantin V Sokolov, Sharif M Ridwan, Jan Schuemann, H L Byrne, Alexander F. Bagley, Sunil Krishnan, James F. Hainfeld, Srinivas Sridhar, Sijumon Kunjachan, Department of Radiation Oncology [Boston], Harvard Medical School [Boston] (HMS)-Massachusetts General Hospital [Boston], The University of Texas M.D. Anderson Cancer Center [Houston], Brigham & Women’s Hospital [Boston] (BWH), Harvard Medical School [Boston] (HMS), Dana-Farber Cancer Institute [Boston], Department of Physics and Astronomy [Victoria], University of Victoria [Canada] (UVIC), Centre for Cancer Research and Cell Biology, Queen's University [Belfast] (QUB), School of Physics [Sydney], The University of Sydney, NanoHybrids, Inc. [Austin], Signalisation, radiobiologie et cancer, Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] (UKE), Nanoprobes, Inc, Namur Research Institute for Life Sciences (NARILIS), Institut des Sciences Moléculaires d'Orsay (ISMO), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), NH TherAguix SA [Meylan], Formation, élaboration de nanomatériaux et cristaux (FENNEC), Institut Lumière Matière [Villeurbanne] (ILM), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Far Eastern Federal University (FEFU), Aurorad, Inc [Houston], Physikalisch-Technische Bundesanstalt [Berlin] (PTB), University of Connecticut Health Center [Farmington], Boston University [Boston] (BU), Université de Sherbrooke (UdeS), Northeastern University [Boston], Rice University [Houston], Department of Biomedical Engineering, The University of Texas at Austin, University of Texas at Austin [Austin], Oregon Health and Science University [Portland] (OHSU), and Mayo Clinic [Jacksonville]
- Subjects
theranostics ,Computer science ,medicine.medical_treatment ,Metal nanoparticles ,Nanotechnology ,Theranostic Nanomedicine ,Modelling ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,[SPI]Engineering Sciences [physics] ,0302 clinical medicine ,SDG 3 - Good Health and Well-being ,Vaccine adjuvant ,medicine ,Theranostic Nanomedicine/methods ,Nanoparticle imaging ,Humans ,[CHIM]Chemical Sciences ,Hyperthermia ,Radiology, Nuclear Medicine and imaging ,metal nanoparticles ,radiotherapy ,[PHYS]Physics [physics] ,Radiological and Ultrasound Technology ,Radiotherapy ,Induced ,Radiation dose ,modeling ,Hyperthermia, Induced ,Theranostics ,Therapeutic applications of nanoparticles ,Radiation therapy ,therapeutic applications of nanoparticles ,Hyperthermia induced ,030220 oncology & carcinogenesis ,Drug delivery ,Metal Nanoparticles/therapeutic use ,immunotherapy ,Immunotherapy ,nanoparticle imaging - Abstract
International audience; This roadmap outlines the potential roles of metallic nanoparticles (MNPs) in the field of radiation therapy. MNPs made up of a wide range of materials (from Titanium, Z = 22, to Bismuth, Z = 83) and a similarly wide spectrum of potential clinical applications, including diagnostic, therapeutic (radiation dose enhancers, hyperthermia inducers, drug delivery vehicles, vaccine adjuvants, photosensitizers, enhancers of immunotherapy) and theranostic (combining both diagnostic and therapeutic), are being fabricated and evaluated. This roadmap covers contributions from experts in these topics summarizing their view of the current status and challenges, as well as expected advancements in technology to address these challenges.
- Published
- 2020
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