Search

kirsten.ahring not provided and Mads Kjolby Department Of Biomedicine

Violi, F., Davi, G., Proietti, M., Pastori, D., Hiatt, W. R., Corazza, G. R., Perticone, F., Pignatelli, P., Farcomeni, A., Vestri, A. R., Lip, G. Y. H., Basili, S, ARAPACIS (Atrial Fibrillation Registry for Ankle-Brachial Index Prevalence Assessment-Collaborative Italian Study) STUDY Investigators. Alessandri C. (Dipartimento di Scienze e Biotecnologie Medico-Chirurgiche, Sapienza-Università di Roma), Serviddio G. (Department of Medical and Surgical Sciences, University of Foggia), (UOC Medicina Generale, Fascetti S., USL 12 Viareggio, Toscana), (UOC Medicina Interna I, Palange P., Dipartimento di Sanità Pubblica, e Malattie Infettive, Sapienza-Università di Roma), Greco, E., (Medicina 3, Bruno G., Department of Medical Sciences, Città della Salute e della Scienza, A. O., University of Turin), Averna, M., (Dipartimento Biomedico di Medicina Interna e Specialistica, Giammanco A., Università di Palermo), Sposito P. (Azienda Ospedaliera Ospedali Riuniti Papardo Piemonte, Messina), De Cristofaro, R., (Istituto di Medicina Interna e Geriatria, De Gennaro L., Centro Emostasi, e Trombosi, Gemelli, Policlinico A., Roma), Carulli, L., (UO di Medicina a Indirizzo Nutrizionistico e Metabolico, Pellegrini E., Università degli Studi di Modena e Reggio Emilia), Dipartimento Integrato di Medicina Endocrinologia Metabolismo e Geriatria., Cominacini, L., Mozzini, C., (Dipartimento di Medicina, Pasini A. F., Sezione di Medicina Interna, D, Università di Verona), Sprovieri, M., (UOC Medicina d'Urgenza e PS, Spagnuolo V., Stabilimento Ospedaliero dell'Annunziata, Cosenza), (UOC Medicina Interna per l'Urgenza, Cerqua G., S Giovanni Addolorata, Ao, Cerasola G., Mulé G. (Università degli Studi di Palermo), Barbagallo, M., Lo Sciuto, S., (UOC di Geriatria e Lungodegenza, Monteverde A., Azienda Ospedaliera Universitaria Policlinico, Aoup, Palermo), Saitta, A., (UOC Medicina Interna, Lo Gullo A., Università di Messina), Malatino, L., Cilia, C., Terranova, V., (Clinica Medica, Pisano M., Ospedale, Cannizzaro, Università degli Studi di Catania), Pinto, A., Di Raimondo, D., Tuttolomondo, A., (Internal Medicine and Cardio-Angiology Ward, Conigliaro R., Department of Biomedicine and Internal Medicine, University of Palermo), Signorelli S. (Dipartimento di Medicina Interna e Patologia, Università degli Studi di Catania), De Palma, D., Galderisi, M., (Dipartimento di Medicina Clinica e Sperimentale, Cudemo G., AUP Federico II di Napoli), Galletti, F., (Dipartimento di Medicina Clinica e Chirurgia, Fazio V., Università di Napoli Federico II), De Luca, N., (Centro Ipertensione, Meccariello A., AUO Federico II, Napoli), Caputo, D., (UO Medicina Interna, De Donato M. T., Azienda Ospedaliera Universitaria San Giovanni di Dio, e Ruggi D'Aragona, Salerno), Iannuzi, A., (Divisione di Medicina Interna, Bresciani A., Cardarelli, Osp. A., (V Divisione Medicina Interna ed Immunoallergologia, Giunta R., Policlinico, Sun, Utili, R., (Medicina Infettivologica e dei Trapianti, Iorio V., Seconda Università di Napoli, AORN dei Colli-Monaldi), Adinolfi, L. E., Sellitto, A., (Medicina Interna, Iuliano N., Ospedale di Marcianise), Bellis, P., (UOC Medicina Interna e di Urgenza e Pronto Soccorso, Tirelli P., del Loreto Nuovo, P. O. S. M., Loreto, Mare), (Clinica Medica 5, Sacerdoti D., Dipartimento di Medicina DIMED, Università degli Studi di Padova), (UO Medicina Interna Arezzo, Vanni D., Ospedale San Donato, Azienda USL, 8 Arezzo), Iuliano, L., Ciacciarelli, M., (Department of Medico-Surgical Sciences and Biotechnology, Pacelli A., Vascular Biology, Mass Spectrometry Lab, Sapienza-University of Rome), Palazzuoli A. (UOS Malattie Cardiovascolari Dipartimento di Scienze Mediche Chirurgiche e Neuroscienze, Università di Siena), Cacciafesta, M., Gueli, N., Lo Iacono, C., Brusco, S., (UOC di Medicina Geriatrica e Riabilitazione, Verrusio W., Sapienza-Università di Roma, Nobili, L., Tarquinio, N., (UO Medicina 'SS Benvenuto e Rocco', Pellegrini F., Dipartimento di Medicina Interna, Asur, Marche, Area Vasta, n. 2., ex ZT 7), (UOS Breve Osservazione, Vincentelli G. M., Calibita 'Fatebenefratelli' Isola Tiberina, Ospedale S. G., Ravallese, F., (UOC Medicina Interna, Santini C., Ospedale, Vannini, Letizia, C., Petramala, L., (UOD Ipertensione Secondaria, Zinnamosca L., Dipartimento di Medicina Interna, e Specialità Mediche, Minisola, S., Cilli, M., Savoriti, C., (UOC Medicina Interna F e Malattie Metaboliche dell'osso- Sapienza-Università di Roma), Colangelo L., Falaschi, P., Martocchia, A., (UO Geriatria, Pastore F., Andrea, Azienda Ospedaliera S., Facoltà diMedicina, e Psicologia, Bertazzoni, G., (UOC Medicina d’Urgenza, Attalla El Halabieh E., Dipartimento di Emergenza ed Accettazione, Paradiso, M., Lizzi, E. M., (Ospedale San Giovanni Battista, Timmi S., Ordine di Malta, (Medicina Interna II, Battisti P., Ospedale San Giovanni-Addolorata, (UOC Medicina Interna, Cerci S., Ospedali Riuniti Frascati, Marino), (UOC Cardiologia-UTIC, Ciavolella M., Ospedale di Frascati, (Centro dell’Ipertensione Arteriosa e delle Malattie Metaboliche e Renali, Di Veroli C., Casa di Cura 'San Domenico', Malci, F., (UOC di Medicina Interna, De Ciocchis A., Ospedale, ASL Roma, G, Subiaco), Abate, D. (Az., Castellino, P., Zanoli, L., (UOC Medicina Interna, Fidone F., Dipartimento di Medicina Clinica, e Sperimentale, Mannarino, E., Pasqualini, L., (Medicina Interna, Oliverio G., Università degli Studi di Perugia), Pende, A., (Clinica di Medicina Interna 1, Artom N., Università di Genova, San Martino - IST), IRCCS Az. Osp. Univ., Ricchio, R., (UOC Geriatria, Fimognari F. L., Azienda Ospedaliera di Cosenza, Alletto, M., (Unità Operativa di Medicina, Messina S., Elia, Ospedale S., Caltanissetta), Sesti, G., Arturi, F., Fiorentino, T. V., (Università degli Studi, Pedace E., UOC Medicina Interna, Policlinico Universitario 'Mater Domini'), Scarpino, P. E., Carullo, G., Maio, R., (Cattedra di Medicina Interna, Sciacqua A., UO Malattie Cardiovascolari, Campus Universitario di Germaneto, Università Magna Graecia di Catanzaro), Frugiuele, P., (UOC Medicina Interna e Reumatologia, Spagnuolo V., Stabilimento Ospedaliero Annunziata, Azienda Ospedaliera Cosenza), (UO Lungodegenza, Battaglia G., Serra San Bruno, S. O., ASP Vibo Valentia), Atzori, S., (Clinica Medica, Delitala G., Aou, Sassari), Angelucci, E., (UOC di Clinica Medica, Sestili S., PO Clinicizzato di Chieti), Traisci, G., (UOC Medicina Interna 2, De Feudis L., PO di Pescara), Di Michele, D., (UOC Medicina Interna, Fava A., Asl, Teramo), Balsano, C., (Dipartimento di Medicina Interna e Sanità Pubblica, De Ciantis P., Università, dell'Aquila), Desideri, G., (UOC Geriatria e Lungodegenza Geriatrica, Camerota A., Dipartimento Medico ORM, Avezzano), Po, Mezzetti M. (UOC Medicina Interna Ospedale del Casentino-Direttore Dr. Emilio Santoro, AUSL8 Arezzo), Gresele, P., Vedovati, C., (Dipartimento di Medicina Interna, Fierro T., Sezione di Medicina Interna, e Cardiovascolare, Università di Perugia), (Centro Aterosclerosi, Puccetti L., Trombosi, e Coagulopatie, Università degli Studi di Siena, Azienda Ospedaliero-Universitaria Senese), Bertolotti, M., (UO Geriatria, Mussi C., Boddi, M., Savino, A., Contri, S., (Dipartimento di Medicina Sperimentale e Clinica, Degl'Innocenti G., Università degli Studi di Firenze), Saller, A., (Clinica Medica 1, Fabris F., Medicina Interna CLOPD, Departement of Medicine DIMED, University of Padova), Pesavento, R., Filippi, L., (Dipartimento di Scienze Cardiologiche, Vedovetto V., Toraciche, e Vascolari, Clinica Medica, 2, Azienda Ospedaliera-Università di Padova), (Clinica Medica IV, Puato M., Dipartimento di Medicina, Azienda Ospedaliera Universitaria Padova, Padova), Fabris, F., (UOA Medicina, Treleani M., Policlinico, Universitario, De Luca, E., De Zaiacomo, F., (Clinica Geriatrica, Giantin V., Università di Padova), (Medicina Interna 1, Semplicini A., Giovanni e Paolo, Ospedale SS., Venezia), Minuz, P., (Sezione di Medicina Interna C, Romano S., Università di Verona, Aoui, Verona), Fantin, F., (Dipartimento di Medicina, Manica A., Sezione di Geriatria, Stockner, I., Pattis, P., Wiedermann, Gutmann B. (Divisione di Medicina Interna-Direttore Prof. J., Ospedale Centrale di Bolzano), Catena, C., Colussi, G., (Clinica Medica, Sechi L. A., Dipartimento di Scienze Mediche Sperimentali, e Cliniche, Università di Udine, Italy), Annoni, G., Bruni, A. A., (Clinica Geriatrica, Castagna A., Università degli Studi di Milano-Bicocca, Dipartimento di Medicina, e Chirurgia, AO San Gerardo, Monza), (Medicina Interna 1, Spinelli D., Dipartimento di Scienze Cliniche, e di Comunità, Fondazione, Irccs, Università di Milano), (Clinica Medica I, Miceli E., Reparto, 11, IRCCS Policlinico San Matteo di Pavia), Schinco, G., (UOC Geriatria, Spreafico S., Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico), (UOC Medicina Interna, Secchi B., Ospedale, Bassini, Milano), Vanoli, M., Casella, G., (SC Medicina Interna, Pulixi E. A., Azienda Ospedaliera della Provincia di Lecco, Ospedale di Merate, Lecco), Sansone, L., (UOC Medicina, Serra M. G., Panico', Azienda Ospedaliera 'Cardinale G., Tricase, (Lecce), Longo, S., (UOC Medicina Interna, Antonaci S., Azienda Ospedaliera Policlinico, Bari), Belfiore, A., Frualdo, M., Palasciano, G., Murri'- Bari), Ricci L. (Clinica Medica 'A., (Struttura Complessa di Medicina Interna, Ventrella F., Cerignola, Asl, Foggia), (UOC Medicina Interna, Bianco C., Tropea), Santovito, D., (Centro di Eccellenza Europeo e di Riferimento Regionale per l'Aterosclerosi, Cipollone F., l'Ipertensione Arteriosa, e le Dislipidemie, Università, Chieti), Nicolai, S., (UO Medicina Interna, Salvati F., Ospedale di Ortona, ASL 02 Abruzzo), Rini, G. B., (UOC Medicina Interna ed Ipertensione, Scozzari F., Dipartimento Biomedico di Medicina Interna, e Specialistica, Giaccone' di Palermo), Policlinico 'P., Muiesan, M. L., Salvetti, M., (Dipartimento di Scienze Cliniche e Sperimentali, Bazza A., Università di Brescia, 2° Medicina Generale Spedali Civili), Picardi, A., Vespasiani-Gentilucci, U., (Medicina Interna e Epatologia, De Vincentis A., Università Campus Bio-Medico, Cosio, P., (Medicina Interna 1, Terzolo M., Dipartimento di Scienze Cliniche, e Biologiche, AOU San Luigi Gonzaga, Università di Torino), Madaffari, B., (UO Medicina Interna, Parasporo B., Azienda Ospedaliera Bianchi Melacrino Morelli, Reggio, Calabria), Fenoglio, L., Bracco, C., (SC Medicina Interna, Melchio R., Croce e Carle, AO S., Cuneo), Gentili, T., (Medicina Generale - Settore Subintensivo, Salvi A., Azienda Ospedaliero- Universitaria, Ancona), (Medicina Generale - Settore Ordinario, Nitti C., Azienda, Ospedaliero-Universitaria, Gabrielli, A., (Clinica Medica, Martino G. P., Capucci, A., Brambatti, M., (Clinica di Cardiologia, Sparagna A., Ospedale, Torrette, (UO Medicina Generale IV, Tirotta D., Ospedale, Cervesi, Cattolica), Andreozzi, P., Ettorre, E., Viscogliosi, G., Servello, A., (Area Geriatria, Musumeci M., DAI Medicina Interna, Rossi Fanelli, F., Delfino, M., (UOC Medicina Interna H, Giorgi A., Sapienza- Università di Roma), Glorioso, N., Melis, G., Marras, G., (Ambulatorio Ipertensione Arteriosa e Patologie Correlate, Matta M., (UOC Medicina Interna, Sacco A., PO Madonna delle Grazie, Matera), Stellitano, E., (UO Medicina, Scordo A., PO 'Tiberio Evoli', Melito Porto Salvo), Russo, F., (UOC Medicina Generale di Rogliano, Caruso A. A., AO di Cosenza), Porreca, E., (UO Medicina Interna e Geriatria, Tana M., D'Annunzio, Università G., Chieti-Pescara), Ferri, C., (Divisione di Medicina Interna e Nefrologia - Ospedale San Salvatore, Cheli P., Dipartimento, Mesva, (Clinica Medica 'Murri', Portincasa P., Dipartimento di Scienze Mediche, e Oncologia Umana, Università degli Studi di Bari), Muscianisi G. (ASP Reggio Calabria, Saline Joniche), Giordani, S., (Dipartimento di Scienze Mediche e Chirurgiche, Stanghellini V., Università degli Studi di Bologna), Sabbà C. (UOC Geriatria e Centro di assistenza e ricerca sovraziendale per le malattie rare, Bari), Mancuso, G., Bartone, M., (UOC Medicina Interna, Calipari D., Presidio, Ospedaliero, ASP di Catanzaro), Arcidiacono, G., (UOC Cardiologia e UTIC, Bellanuova I., Catania), Ferraro M., Marigliano G. (ASP Cosenza), Cozzolino, D., Lampitella, A., (Dipartimento di Internistica Clinica e Sperimentale, Acri V., Seconda Università di Napoli), Galasso, D., Mazzei, F., (RSA Madonna di Porto Gimigliano, Galasso S., Catanzaro), (Azienda Ospedaliera della Provincia di Pavia, Buratti A., UO Medicina Interna, Ospedale, Civile, Casorate, Primo, Pavia), Porta, M., (SC Medicina Interna 1U, Brizzi M. F., Azienda, Ospedaliera, Torino), Fattorini, A., Sampietro, F., (Servizio di Coagulazione ed Unità Ricerca Trombosi, D’Angelo A., IRCCS Ospedale San Raffaele, Manfredini, R., Pala, M., (UOC Clinica Medica, Fabbian F., Anna, Azienda Ospedaliera- Universitaria S., Ferrara), Moroni, C., Valente, L., (Laboratorio di Ecocardiografia- Cardiologia Preventiva, Lopreiato F., DAI Cuore, e Grossi Vasi, (UOC Medicina Interna, Parente F., Lecce), (Immunologia Clinica A, Granata M., Moia, M., (Fondazione IRCCS Ca'Granda, Braham S., Ospedale Maggiore Policlinico, Rossi, M., (Dipartimento di Medicina Clinica e Sperimentale, Pesce M., Università di Pisa), Gentile, A., (UO Medicina, Catozzo V., Ldp, Loreto, Baciarello, G., (UOC Cardiologia Preventiva e Riabilitativa, Cosimati A., Ageno, W., Rancan, E., (Dipartimento di Medicina Clinica e Sperimentale, Guasti L., Università, Dell'Insubria, Varese), Ciccaglioni, A., Negri, S., (Centro Elettro-Stimolazione Cardiaca, Polselli M., Prisco, D., (SOD Patologia Medica, Marcucci R., Aou, Careggi, Firenze), Ferro, D., Cangemi, R., Perri, L., Polimeni, L., Catasca, E., Vicario, T., Russo, R., Saliola, M., Del Ben, M., Angelico, F., Calvieri, C., Bucci, T., (I Clinica Medica, Baratta F., Migliacci, R., Medicina Interna, Porciello G. (S. C., Ospedale della Valdichiana, Cortona, Usl, 8 Arezzo), (Dipartimento BioMedico di Medicina Interna e Specialistica, Corrao S., Università degli Studi di, Palermo). Simi Young Internists (GIS) Group: Anzaldi M., Bazzini, C., Bianchi, P. I., Boari, B., Buonauro, A., Buttà, C., Buzzetti, E., Calabria, S., Capeci, W., Caradio, F., Carleo, P., Carrabba, M. D., Castorani, L., Cecchetto, L., Cicco, S., Cimini, C., Colombo, B. M., De Giorgi, A., De Vuono, S., Del Corso, L., Denegri, A., Di Giosia, P., Durante Mangoni, E., Falsetti, L., Forgione, A., Giorgini, P., Grassi, D., Grembiale, A., Hijazi, D., Iamele, L., Lorusso, G., Marchese, A., Marra, A. M., Masala, M., Miceli, G., Montebianco Abenavoli, L., Murgia, G., Naccarato, P., Padula, D., Pattoneri, P., Perego, F., Pesce, P., Piano, S., Pinna, M., Pinto, D., Pretti, V., Pucci, G., Raparelli, V., Salinaro, F., Salzano, A., Santilli, F., Scarpini, F., Scicali, R., Sirico, D., Suppressa, P., Talia, M., Tassone, E. J., Torres, D., Vazzana, N., Vecchio, C. R., Vidili, G., Vitale, F., Zaccone, V., Alessandri, C., Serviddio, G., Palange, P, Greco, E, Bruno, G, Averna, M, Giammanco, A, Sposito, P, De Cristofaro, R., De Gennaro, L, Carulli, L, Pellegrini, E, Cominacini, L, Mozzini, C, Pasini, Af, Sprovieri, M, Spagnuolo, V, Cerqua, G, Cerasola, G, Mulé, G, Barbagallo, M, Lo Sciuto, S, Monteverde, A, Saitta, A, Lo Gullo, A, Malatino, L, Cilia, C, Terranova, V, Pisano, M, Pinto, A, Di Raimondo, D, Tuttolomondo, A, Conigliaro, R, Signorelli, S, De Palma, D, Galderisi, M, Cudemo, G, Galletti, F, Fazio, V, De Luca, N, Meccariello, A, Caputo, D, De Donato, Mt, Iannuzi, A, Bresciani, A, Giunta, R, Utili, R, Iorio, V, Adinolfi, Luigi Elio, Sellitto, A, Iuliano, N, Bellis, P, Tirelli, P, Sacerdoti, D, Vanni, D, Iuliano, L, Ciacciarelli, M, Pacelli, A, Palazzuoli, A, Cacciafesta, M, Gueli, N, Lo Iacono, C, Brusco, S, Verrusio, W, Nobili, L., Tarquinio, N., Pellegrini, F, Vincentelli, G. M., Ravallese, F, Santini, C, Letizia, C, Petramala, L, Zinnamosca, L, Minisola, S., Cilli, M, Savoriti, C, Colangelo, L, Falaschi, P, Martocchia, A, Pastore, F., and DURANTE MANGONI, Emanuele

Steven Van Laere, Mieke Dewerchin, Lena-Christin Conradi, Peter Carmeliet, Anna Rita Cantelmo, Federico Taverna, Massimiliano Mazzone, Yonglun Luo, Stefan Vinckier, Stefaan J. Soenen, Nuphar Veiga, Tobias K. Karakach, Peter B. Vermeulen, Lucas Treps, Joanna Kalucka, Sébastien J. Dumas, Luc Dirix, Elda Meta, Shawez Khan, Vincent Geldhof, Guy Eelen, Laure-Anne Teuwen, Luc Schoonjans, Nadine V. Conchinha, Katerina Rohlenova, Lisa M. Becker, Anne Cuypers, Melissa García-Caballero, Laura P.M.H. de Rooij, Jacob Amersfoort, [Teuwen,LA, De Roji,PMH, Cuypers,A, Rohlenova,A, Dumas,SH, García-Caballero,M, Meta,E, Amersfoort,J, Taverna,F, Becker,LM, Veiga,N, Cantelmo,AR, Geldhof,V, Conchinha,NV, Kalucka,J, Treps,L, Conradi,LC, Khan,S, Karakach,TK, Vinckier,S, Schoonjans,L, Eelen,G, Dewerchin,M, Carmeliet,P] Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology (CCB), VIB, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven, Belgium. [Teuwen,LA, Van Laere,S, Dirix,L, Vermeulen,P] Translational Cancer Research Unit, GZA Hospitals Sint-Augustinus, Antwerp, Belgium. [Teuwen,LA, Vermeulen,P] Center for Oncological Research, University of Antwerp, Antwerp, Belgium. [Soenen,S] NanoHealth and Optical Imaging Group, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium. [Schoonjans,L, Carmeliet,P] State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China. [Mazzone,M] Laboratory of Tumor Inflammation and Angiogenesis, CCB, VIB, Department of Oncology, Leuven Cancer Institute, KU Leuven, Leuven, Belgium. [Luo,Y] Department of Biomedicine, Aarhus University, Aarhus, Denmark. [Luo,Y] Lars Bolund Institute of Regenerative Medicine, BGI-Qingdao, Qingdao, P.R. China. [Luo,Y] BGI-Shenzhen, Shenzhen, China. [Luo,Y] China National GeneBank, BGI-Shenzhen, Shenzhen, P.R. China. [Carmeliet,P] Laboratory of Angiogenesis and Vascular Heterogeneity, Department of Biomedicine, Aarhus University, Aarhus, Denmark. [Rohlenova,K] Institute of Biotechnology of the Czech Academy of Sciences, Praha – za´ pad, Central Bohemia, Czechia. [García-Caballero,M] Department of Molecular Biology and Biochemistry, Faculty of Sciences, and IBIMA (Biomedical Research Institute of Málaga), University of Málaga, Andalucía Tech, Málaga, Spain. [Cantelmo,AR] Laboratory of Cell Physiology, Lille University, Villeneuve d’Ascq, France. [Kalucka,J] Aarhus Institute of Advanced Studies (AIAS), Department of Biomedicine, Aarhus University, Aarhus, Denmark. [Conradi,LC] Clinic of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany. [Khan,S] National Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital, Herlev, Denmark. [Karakach,TK] Bioinformatics Core Laboratory, Children’s Hospital Research Institute of Manitoba, Winnipeg, Canada. [Karakach,TK] Rady Faculty of Health Sciences, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba Canada., L.-A.T., L.D., S.V.L., and P.V. are supported by Fonds Oncologie Augustinus-Koning Boudewijnstichting and GZA Ziekenhuizen, A.C., K.R., N.V.C., L.P.M.H.d.R., and L.T. by the Fonds Wetenschappelijk Onderzoek (FWO), S.J.D. by a Marie Curie-IEF fellowship, V.G. by Strategisch Basisonderzoek FWO (SB-FWO), Y.L. by BGI-Research, Danish Research Council for Independent Research (DFF-1337-00128), Sapere Aude Young Research Talent Prize (DFF-1335–00763A), and Aarhus University Strategic Grant (AU-iCRISPR), and and P.C. by Methusalem funding (Flemish government), Fund for Scientific Research-Flanders (FWO-Vlaanderen), Foundation Against Cancer (2016-078), Kom op tegen Kanker (Stand up to Cancer, Flemish Cancer Society), European Research Council (ERC Proof of Concept grant ERC-713758 and Advanced ERC Research grant EU-ERC743074), and a NNF Laureate Research Grant from Novo Nordisk Foundation (NNF19OC0055802).

Demontis, Ditte, Walters, Raymond K., Rajagopal, Veera M., Waldman, Irwin D., Grove, Jakob, Als, Thomas D., Dalsgaard, Søren, Ribasas, Marta, Bybjerg-Grauholm, Jonas, Bækvad-Hansen, Maria, Werge, Thomas, Nordentoft, Merete, Mors, Ole, Mortensen, Preben Bo, (PGC), ADHD Working Group of the Psychiatric Genomics Consortium, Andreassen, Ole A., Arranz, Maria Jesús, Banaschewski, Tobias, Bau, Claiton, Bellgrove, Mark, Biederman, Joseph, Brikell, Isabell, Buitelaar, Jan K., Burton, Christie L., Casas, Miguel, Crosbie, Jennifer, Doyle, Alysa E., Ebstein, Richard P., Elia, Josephine, Elizabeth, Corfield C., Grevet, Eugenio, Grizenko, Natalie, Havdahl, Alexandra, Hawi, Ziarih, Hebebrand, Johannes, Hervas, Amaia, Hohmann, Sarah, Haavik, Jan, Joober, Ridha, Kent, Lindsey, Kuntsi, Jonna, Langley, Kate, Larsson, Henrik, Lesch, Klaus-Peter, Leung, Patrick W. L., Liao, Calwing, Loo, Sandra K., Martin, Joanna, Martin, Nicholas G., Medland, Sarah E., Miranda, Ana, Mota, Nina Roth, Oades, Robert D., Ramos-Quiroga, Josep Antoni, Reif, Andreas, Rietschel, Marcella, Roeyers, Herbert, Rohde, Luis Augusto, Rothenberger, Aribert, Rovira, Paula, Sánchez-Mora, Cristina, Schachar, Russell James, Sengupta, Sarojini, Artigas, Maria Soler, Steinhausen, Hans-Christoph, Thapar, Anita, Witt, Stephanie H., Yang, Li, Zayats, Tetyana, Zhang-James, Yanli, Cormand, Bru, Hougaard, David M., Neale, Benjamin M., Franke, Barbara, Faraone, Stephen V., Børglum, Anders D., University of St Andrews. School of Medicine, University of St Andrews. Institute of Behavioural and Neural Sciences, University of St Andrews. Cellular Medicine Division, Institut Català de la Salut, [Demontis D, Rajagopal VM, Als TD] The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark. Center for Genomics and Personalized Medicine, Aarhus, Denmark. Department of Biomedicine - Human Genetics, Aarhus University, Aarhus, Denmark. [Walters RK] Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. [Waldman ID] Department of Psychology, Emory University, Atlanta, GA, USA. [Grove J] The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark. Center for Genomics and Personalized Medicine, Aarhus, Denmark. Department of Biomedicine - Human Genetics, Aarhus University, Aarhus, Denmark. [Ribasés M] Unitat de Psiquiatria Genètica, Grup de recerca en Psiquiatria, salut mental i addiccions, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Servei de Psiquiatria, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Biomedical Network Research Center on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain. Departament de Genètica, Microbiologia i Estadística, Facultat de Biologia, Universitat de Barcelona, Barcelona, Catalonia, Spain, and Vall d'Hebron Barcelona Hospital Campus

Geraldine Dawson, Sven Sandin, Frederico Duque, Peter Holmans, Marion Leboyer, Aarno Palotie, Fritz Poustka, Richard Delorme, Stephen Sanders, Alistair T. Pagnamenta, Lonnie Zwaigenbaum, Bridget A. Fernandez, A. Jeremy Willsey, Christine M. Freitag, Christa Lese Martin, Elena Maestrini, Elena Bacchelli, Guiomar Oliveira, Jeremy R. Parr, Guy A. Rouleau, Jonas Bybjerg-Grauholm, Joseph Piven, Latha Soorya, Lauren A. Weiss, Jonathan Green, Carsten Bøcker Pedersen, Louise Gallagher, Regina Regan, Stephan Ripke, Thomas Werge, Pat Levitt, Aravinda Chakravarti, Joana Almeida, Kathryn Roeder, Catalina Betancur, Bernie Devlin, Benjamin M. Neale, Gillian Baird, Jakob Grove, Thomas Bourgeron, David H. Ledbetter, Eftichia Duketis, Karola Rehnström, Gerard D. Schellenberg, Jillian P. Casey, Preben Bo Mortensen, Patrick Bolton, Igor Martsenkovsky, Elise Robinson, Hakon Hakonarson, Vanessa H. Bal, Stacy Steinberg, Christopher Gillberg, Kathryn Tsang, Jacob A. S. Vorstman, Verneri Anttila, Suma Jacob, Judith Conroy, J. Haines, William M. McMahon, Edwin H. Cook, Ann P. Thompson, Inês C. Conceição, Mark J. Daly, Arthur P. Goldberg, Sarah E. Medland, Milica Pejovic-Milovancevic, David M. Hougaard, Shrikant Mane, Christina M. Hultman, Susana Mouga, Hreinn Stefansson, Ellen M. Wijsman, Andreas G. Chiocchetti, Ole Mors, Phil Lee, Richard Anney, Astrid M. Vicente, Veronica J. Vieland, K. Stefansson, Stephen W. Scherer, Teimuraz Silagadze, Pall Magnusson, Donna M. Martin, Merete Nordentoft, Peter Szatmari, Patrícia B. S. Celestino-Soper, Ann S Le-Couteur, Cátia Café, Arthur L. Beaudet, Kerstin Wittemeyer, Anders D. Børglum, Joel S. Bader, Christopher S. Poultney, Hailiang Huang, Alexander Kolevzon, Margaret A. Pericak-Vance, Joachim Hallmayer, Rita M. Cantor, Eric Fombonne, Andrew Green, Dan E. Arking, M. Daniele Fallin, Matthew W. State, Christine Ladd-Acosta, Silvia Derubeis, Raphael Bernier, Regina Waltes, David G. Amaral, Manuel Mattheisen, Abraham Reichenberg, Lambertus Klei, Daniel Moreno-De-Luca, Marie Bækvad-Hansen, Maretha V. Dejonge, Susan G. McGrew, Joseph D. Buxbaum, Hilary Coon, Jennifer Reichert, Michael Gill, Herman Vanengeland, Christine Søholm Hansen, Anthony P. Monaco, Nadia Bolshakova, John I. Nurnberger, Nancy J. Minshew, Michael T. Murtha, Thomas H. Wassink, Evald Saemundsen, Simon Wallace, Sean Brennan, Sean Ennis, A. Gulhan Ercan-Sencicek, Sven Bölte, Oscar Svantesson, Susan L. Santangelo, Andrew D. Paterson, Robert L. Hendren, Timothy W. Yu, Dalila Pinto, D.E. Grice, Alison Merikangas, Stephen J. Guter, Anthony J. Bailey, Bernadette Rogé, Christopher A. Walsh, Susan E. Folstein, Wendy Roberts, Sabine M. Klauck, Marianne Giørtz Pedersen, Tiago R. Magalhaes, John R. Gilbert, Irva Hertz-Picciotto, James S. Sutcliffe, Evdokia Anagnostou, Catarina Correia, Eric M. Morrow, Daniel H. Geschwind, Jennifer K. Lowe, Agatino Battaglia, Bozenna Iliadou, Michael L. Cuccaro, Catherine Lord, MRC Centre for Neuropsychiatric Genetics and Genomics [Cardiff, UK], Cardiff University, The Autism Working Group of the Psychiatric Genomics Consortium was supported by National Institutes of Mental Health (NIMH, USA) grant MH109539, MH094432 and MH094421 to M.J.D. The ACE Network was supported by MH081754 and MH100027 to D.H.G. The Autism Genetic Resource Exchange (AGRE) is a program of Autism Speaks (USA) and was supported by grant MH081810. The Autism Genome Project (AGP) was supported by grants from Autism Speaks, the Canadian Institutes of Health Research (CIHR), Genome Canada, the Health Research Board (Ireland, AUT/ 2006/1, AUT/2006/2, PD/2006/48), the Hilibrand Foundation (USA), the Medical Research Council (UK), the National Institutes of Health (USA, the National Institute of Child Health and Human Development and the National Institute of Mental Health), the Ontario Genomics Institute, and the University of Toronto McLaughlin Centre. The Simons Simplex Collection (SSC) was supported by a grant from the Simons Foundation (SFARI 124827 to the investigators of the Simons Simplex Collection Genetic Consortium), approved researchers can obtain the SSC population dataset described in this study (http://sfari.org/resources/sfari-base) by applying at https://base.sfari.org. The Gene Discovery Project of Johns Hopkins was funded by MH060007, MH081754, and the Simons Foundation. The MonBos Collection study was funded in part through a grant from the Autism Consortium of Boston. Support for the Extreme Discordant Sib-Pair (EDSP) family sample (part of the MonBos collection) was provided by the NLM Family foundation. Support for the Massachusetts General Hospital (MGH)–Finnish collaborative sample was provided by NARSAD. The PAGES collection was funded by NIMH grant MH097849. The collection of data and biomaterials that participated in the NIMH Autism Genetics Initiative has been supported by National Institute of Health grants MH52708, MH39437, MH00219, and MH00980, National Health Medical Research Council grant 0034328, and by grants from the Scottish Rite, the Spunk Fund, Inc., the Rebecca and Solomon Baker Fund, the APEX Foundation, the National Alliance for Research in Schizophrenia and Affective Disorders (NARSAD), the endowment fund of the Nancy Pritzker Laboratory (Stanford), and by gifts from the Autism Society of America, the Janet M. Grace Pervasive Developmental Disorders Fund, and families and friends of individuals with autism. The iPSYCH project is funded by The Lundbeck Foundation and the universities and university hospitals of Aarhus and Copenhagen. In addition, the genotyping of iPSYCH samples was supported by grants from the Stanley Foundation, the Simons Foundation (SFARI 311789 to MJD), and NIMH (5U01MH094432-02 to MJD). The Study to Explore Early Development (SEED) was funded by the Centers for Disease Control and Prevention (CDC) grants U10DD000180, U10DD000181, U10DD000182, U10DD000183, U10DD000184, and U10DD000498. Statistical analyses were carried out on the Genetic Cluster Computer (http://www.geneticcluster.org) hosted by SURFsara and financially supported by the Netherlands Scientific Organization (NWO 480-05-003), along with a supplement from the Dutch Brain Foundation and the VU University Amsterdam. Additional statistical analyses were performed and supported by the Trinity Centre for High Performance Computing (http://www.tchpc.tcd.ie/) funded through Science Foundation Ireland. Computational support for the PAGES collection was provided in part through the computational resources and staff expertise of the Department of Scientific Computing at the Icahn School of Medicine at Mount Sinai (https://hpc.mssm.edu). Data QC and statistical analyses of the iPSYCH samples were performed at the high-performance computing cluster GenomeDK (http://genome.au.dk) at the Center for Integrative Sequencing, iSEQ, Aarhus University. iSEQ provided computed time, data storage, and technical support for the study., Richard JL Anney, Email: anneyr@cardiff.ac.uk, Affiliation/s: MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, CF24 4HQ, UK, Department of Psychiatry, Trinity College Dublin, Dublin, D8, Ireland. Stephan Ripke, Email: ripke@atgu.mgh.harvard.edu, Affiliation/s: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA, Stanley Center for Psychiatric Research and Program in Medical and Population Genetic, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA, Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, CCM, Berlin 10117, Germany. Verneri Anttila, Affiliation/s: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA, Stanley Center for Psychiatric Research and Program in Medical and Population Genetic, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Jakob Grove, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, DK-8000, Denmark, Department of Biomedicine - Human Genetics, Aarhus University, Aarhus, DK-8000, Denmark, Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark. Peter Holmans, Affiliation/s: MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, CF24 4HQ, UK. Hailiang Huang, Affiliation/s: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA, Stanley Center for Psychiatric Research and Program in Medical and Population Genetic, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Lambertus Klei, Affiliation/s: Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. Phil H Lee, Affiliation/s: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA, Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA. Sarah E Medland, Affiliation/s: Queensland Institute of Medical Research Brisbane, QLD, 4006, Australia. Benjamin Neale, Affiliation/s: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA, Stanley Center for Psychiatric Research and Program in Medical and Population Genetic, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Elise Robinson, Affiliation/s: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA, Stanley Center for Psychiatric Research and Program in Medical and Population Genetic, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Lauren A Weiss, Affiliation/s: Department of Psychiatry, University of California San Francisco, San Francisco, CA 94143, USA, Inst Human Genetics, University of California San Francisco, San Francisco, CA 94143, USA. Lonnie Zwaigenbaum, Affiliation/s: Department of Pediatrics, University of Alberta, Edmonton, AB, T6G 1C9, Canada. Timothy W Yu, Affiliation/s: Division of Genetics, Children ’ s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA. Kerstin Wittemeyer, Affiliation/s: School of Education, University of Birmingham, Birmingham, B15 2TT, UK. A.Jeremy Willsey, Affiliation/s: Department of Psychiatry, University of California San Francisco, San Francisco, CA 94143, USA. Ellen M Wijsman, Affiliation/s: Department of Medicine, University of Washington, Seattle, WA 98195, USA, Department of Biostatistics, University of Washington, Seattle, WA 98195, USA. Thomas Werge, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Institute of Biological Psychiatry, MHC Sct Hans, Mental Health Services Copenhagen, Roskilde, Denmark, Department of Clinical Medicine, University of Copenhagen, Copenhagen, DK-2200, Denmark. Thomas H Wassink, Affiliation/s: Department of Psychiatry, Carver College of Medicine, Iowa City, IA 52242, USA. Regina Waltes, Affiliation/s: Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, JW Goethe University Frankfurt, Frankfurt am Main, 60528, Germany. Christopher A Walsh, Affiliation/s: Division of Genetics, Children ’ s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA, Program in Genetics and Genomics, Harvard Medical School, Boston, MA 02115, USA, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA, Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA, Simon Wallace, Affiliation/s: Department of Psychiatry, University of Oxford and Warneford Hospital, Oxford, OX3 7JX, UK. Jacob AS Vorstman, Affiliation/s: Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, 3584 CG, The Netherlands. Veronica J Vieland, Affiliation/s: Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children ’ s Hospital, Columbus, OH 43205, USA. Astrid M Vicente, Affiliation/s: Instituto Nacional de Saúde Dr Ricardo Jorge, Lisboa, 1600, Portugal, Center for Biodiversity, Functional and Integrative Genomics, Campus da FCUL, Lisboa, 1649, Portugal. Herman vanEngeland, Affiliation/s: Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, 3584 CG, The Netherlands. Kathryn Tsang, Affiliation/s: Department of Psychiatry, University of California San Francisco, San Francisco, CA 94143, USA, Inst Human Genetics, University of California San Francisco, San Francisco, CA 94143, USA. Ann P Thompson, Affiliation/s: Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, ON, L8S 4L8, Canada. Peter Szatmari, Affiliation/s: Department of Psychiatry, University of Toronto, ON, M5T 1R8, Canada. Oscar Svantesson, Affiliation/s: Karolinska Institutet, Solna, SE-171 77, Sweden. Stacy Steinberg, Affiliation/s: deCODE Genetics, Reykjavik, IS-101, Iceland. Kari Stefansson, Affiliation/s: deCODE Genetics, Reykjavik, IS-101, Iceland. Hreinn Stefansson, Affiliation/s: deCODE Genetics, Reykjavik, IS-101, Iceland. Matthew W State, Affiliation/s: Department of Psychiatry, University of California San Francisco, San Francisco, CA 94143, USA. Latha Soorya, Affiliation/s: Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Department of Psychiatry, Rush University Medical Center, Chicago, IL 60612, USA. Teimuraz Silagadze, Affiliation/s: Department of Psychiatry and Drug Addiction, Tbilisi State Medical University, Tbilisi, 0186, Georgia. Stephen W Scherer, Affiliation/s: The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, M5G 1L4, Canada, McLaughlin Centre, University of Toronto, Toronto, ON, M5G 0A4, Canada, Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada. Gerard D Schellenberg, Affiliation/s: Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19102, USA. Sven Sandin, Affiliation/s: Karolinska Institutet, Solna, SE-171 77, Sweden. Stephan J Sanders, Affiliation/s: Department of Psychiatry, University of California San Francisco, San Francisco, CA 94143, USA. Evald Saemundsen, Affiliation/s: State Diagnostic and Counseling Centre, Kopavogur, IS-201, Iceland. Guy A Rouleau, Affiliation/s: Montreal Neurological Institute, Dept of Neurology and Neurosurgery, McGill University, Montreal, QC, H3A 2B4, Canada. Bernadette Rogé, Affiliation/s: Centre d ’ Etudes et de Recherches en Psychopathologie, Toulouse University, Toulouse, 31058, France. Kathryn Roeder, Affiliation/s: Department of Computational Biology, Carnegie Mellon University, Pittsburgh, PA 15213, USA, Department of Statistics, Carnegie Mellon University, Pittsburgh, PA 15213, USA. Wendy Roberts, Affiliation/s: Autism Research Unit, The Hospital for Sick Children, Toronto, ON, M5G 1L4, Canada. Jennifer Reichert, Affiliation/s: Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Abraham Reichenberg, Affiliation/s: Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Karola Rehnström, Affiliation/s: Sanger Institute, Hinxton, CB10 1SA, UK. Regina Regan, Affiliation/s: National Childrens Research Centre, Our Lady ’ s Hospital Crumlin, Dublin, D12, Ireland, Academic Centre on Rare Diseases, University College Dublin, Dublin, D4, Ireland. Fritz Poustka, Affiliation/s: Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, JW Goethe University Frankfurt, Frankfurt am Main, 60528, Germany. Christopher S Poultney, Affiliation/s: Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Joseph Piven, Affiliation/s: University of North Carolina, Chapel Hill, NC 27599, USA. Dalila Pinto, Affiliation/s: Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, The Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA Margaret A Pericak-Vance, Affiliation/s: The John P Hussman Institute for Human Genomics, University of Miami, Miami, FL 33101, USA. Milica Pejovic-Milovancevic, Affiliation/s: Institute of Mental Health and Medical Faculty, University of Belgrade, Belgrade, 11 000, Serbia. Marianne Giørtz Pedersen, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, National Centre for Register-based Research, Aarhus University, Aarhus, Denmark, Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark. Carsten Bøcker Pedersen, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark. Andrew D Paterson, Affiliation/s: Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada, The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, M5G 1L4, Canada, Dalla Lana School of Public Health, Toronto, ON, M5T 3M7, Canada. Jeremy R Parr, Affiliation/s: Institute of Neuroscience, Newcastle University, Newcastle Upon Tyne, NE2 4HH, UK, Institue of Health and Science, Newcastle University, Newcastle Upon Tyne, NE2 4AX, UK. Alistair T Pagnamenta, Affiliation/s: Wellcome Trust Centre for Human Genetics, OxfordUniversity,Oxford,OX37BN,UK. Guiomar Oliveira, Affiliation/s: Unidade de Neurodesenvolvimento e Autismo do Serviço do Centro de Desenvolvimento da Criança and Centro de Investigação e Formação Clinica, Pediatric Hospital, Centro Hospitalar e Universitário de Coimbra, Coimbra, 3041-80, Portugal, University Clinic of Pediatrics and Institute for Biomedical Imaging and Life Science, Faculty of Medicine, University of Coimbra, Coimbra, 3041-80, Portugal. John I Nurnberger, Affiliation/s: Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA, Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA, Program in Medical Neuroscience, Indiana University School of Medicine, Indianapolis, IN 46202, USA. Merete Nordentoft, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Mental Health Services in the Capital Region of Denmark, Mental Health Center Copenhagen, University of Copenhagen, Copenhagen, Denmark. Michael T Murtha, Affiliation/s: Programs on Neurogenetics, Yale University School of Medicine, New Haven, CT 06520, USA. Susana Mouga, Affiliation/s: Unidade de Neurodesenvolvimento e Autismo do Serviço do Centro de Desenvolvimento da Criança and Centro de Investigação e Formação Clinica, Pediatric Hospital, Centro Hospitalar e Universitário de Coimbra, Coimbra, 3041-80, Portugal, University Clinic of Pediatrics and Institute for Biomedical Imaging and Life Science, Faculty of Medicine, University of Coimbra, Coimbra, 3041-80, Portugal. Preben Bo Mortensen, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Na- tional Centre for Register-based Research, Aarhus University, Aarhus, Denmark, Centre for Integrated Register-based Research, Aarhus University, Aarhus, Denmark, Ole Mors, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Psychosis Research Unit, Aarhus University Hospital, Risskov, Denmark. Eric M Morrow, Affiliation/s: Department of Psychiatry and Human Behaviour, Brown University, Providence, RI 02912, USA. Daniel Moreno-De-Luca, Affiliation/s: Department of Psychiatry and Hu- man Behaviour, Brown University, Providence, RI 02912, USA. Anthony P Monaco, Affiliation/s: Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, OX3 7BN, UK, Tufts University, Boston, MA 02155?, USA. Nancy Minshew, Affiliation/s: Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. Alison Merikangas, Affiliation/s: Department of Psychiatry, Trinity College Dublin, Dublin, D8, Ireland. William M McMahon, Affiliation/s: Department of Psychiatry, University of Utah, Salt Lake City, UT 84108, USA. Susan G McGrew, Affiliation/s: Department of Pediatrics, Vanderbilt University, Nashville, TN 37232, USA. Manuel Mattheisen, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Department of Biomedicine - Human Genetics, Aarhus University, Aarhus, DK-8000, Denmark. Igor Martsenkovsky, Affiliation/s: Department of Child, Adolescent Psychiatry and Medical-Social Rehabilitation, Ukrainian Research Institute of Social Fo- rensic Psychiatry and Drug Abuse, Kyiv, 04080, Ukraine. Donna M Martin, Affiliation/s: Department of Pediatrics and Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA. Shrikant M Mane, Affiliation/s: Yale Center for Genomic Analysis, Yale University School of Medicine, New Haven, CT 06516, USA. Pall Magnusson, Affiliation/s: Department of Child and Adolescent Psychiatry, National University Hospital, Reykjavik, IS-101, Iceland. Tiago Magalhaes, Affiliation/s: National Childrens Research Centre, Our Lady ’ s Hospital Crumlin, Dublin, D12, Ireland, Academic Centre on Rare Diseases, University College Dublin, Dublin, D4, Ireland. Elena Maestrini, Affiliation/s: Department of Pharmacy and Biotechnology, University of Bologna, Bologna, 40126, Italy. Jennifer K Lowe, Affiliation/s: Center for Autism Research and Treatment, Semel Institute, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA, Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA, Center for Neurobehavioral Genetics, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. Catherine Lord, Affiliation/s: Department of Psychiatry, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA. Pat Levitt, Affiliation/s: Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA. Christa LeseMartin, Affiliation/s: Autism and Developmental Medicine Institute, Geisinger Health System, Danville, PA 17837, USA. David H Ledbetter, Affiliation/s: Chief Scientific Officer, Geisinger Health System, Danville, PA 17837, USA. Marion Leboyer, Affiliation/s: FondaMental Foundation, Créteil, 94000, France, INSERM U955, Paris, 94010, France, Faculté de Médecine, Université Paris Est, Créteil, 94000, France, Department of Psychiatry, Henri Mondor-Albert Chene- vier Hospital, Assistance Publique – Hôpitaux de Paris, Créteil, 94000, France, Ann S LeCouteur, Affiliation/s: Institute of Neuroscience, Newcastle University, Newcastle Upon Tyne, NE2 4HH, UK, Institue of Health and Science, Newcastle University, Newcastle Upon Tyne, NE2 4AX, UK. Christine Ladd-Acosta, Affiliation/s: Department of Epidemiology, Johns Hop- kins Bloomberg School of Public Health, Baltimore, MD 21205, USA. Alexander Kolevzon, Affiliation/s: Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Sabine M Klauck, Affiliation/s: Division of Molecular Genome Analysis and Working Group Cancer Genome Research, Deutsches Krebsforschungszentrum, Heidelberg, D-69120, Germany. Suma Jacob, Affiliation/s: Institute for Juvenile Research, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA, Institute of Translational Neuroscience and Department of Psychiatry, University of Minnesota, Minneapolis, MN 55454, USA. Bozenna Iliadou, Affiliation/s: Karolinska Institutet, Solna, SE-171 77, Sweden. Christina M Hultman, Affiliation/s: Karolinska Institutet, Solna, SE-171 77, Sweden. David M Hougaard, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, DK-2300, Denmark. Irva Hertz-Picciotto, Affiliation/s: Department of Public Health Sciences, School of Medicine, University of California Davis, Davis, CA 95616, USA, The MIND Institute, School of Medicine, University of California Davis, Davis, CA 95817, USA. Robert Hendren, Affiliation/s: Department of Psychiatry, University of California San Francisco, San Francisco, CA 94143, USA. Christine Søholm Hansen, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, DK-2300, Denmark. Jonathan L Haines, Affiliation/s: Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA. Stephen J Guter, Affiliation/s: Institute for Juvenile Research, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA. Dorothy E Grice, Affiliation/s: Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Jonathan M Green, Affiliation/s: Manchester Academic Health Sciences Centre, Manchester, M13 9NT, UK, Institute of Brain, Behaviour, and Mental Health, University of Manchester, Manchester, M13 9PT, UK. Andrew Green, Affiliation/s: Academic Centre on Rare Diseases, University College Dublin, Dublin, D4, Ireland, Centre for Medical Genetics, Our Lady ’ s Hospital Crumlin, Dublin, D12, Ireland. Arthur P Goldberg, Affiliation/s: Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, The Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Christopher Gillberg, Affiliation/s: Gillberg Neuropsychiatry Centre, University of Gothenburg, Gothenburg, S-405 30, Sweden. John Gilbert, Affiliation/s: The John P Hussman Institute for Human Genomics, University of Miami, Miami, FL 33101, USA. Louise Gallagher, Affiliation/s: Department of Psychiatry, Trinity College Dublin, Dublin, D8, Ireland. Christine M Freitag, Affiliation/s: Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, JW Goethe University Frankfurt, Frankfurt am Main, 60528, Germany. Eric Fombonne, Affiliation/s: Department of Psychiatry and Institute for Development and Disability, Oregon Health and Science University, Portland, OR 97239, USA. Susan E Folstein, Affiliation/s: Division of Child and Adolescent Psychiatry, Department of Psychiatry, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. Bridget Fernandez, Affiliation/s: Memorial University of Newfoundland, St John ’ s, NL, A1B 3X9, Canada. M.Daniele Fallin, Affiliation/s: Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. A.Gulhan Ercan-Sencicek, Affiliation/s: Programs on Neurogenetics, Yale Uni- versity School of Medicine, New Haven, CT 06520, USA. Sean Ennis, Affiliation/s: Academic Centre on Rare Diseases, University College Dublin, Dublin, D4, Ireland, Centre for Medical Genetics, Our Lady ’ s Hospital Crumlin, Dublin, D12, Ireland. Frederico Duque, Affiliation/s: Unidade de Neurodesenvolvimento e Autismo do Serviço do Centro de Desenvolvimento da Criança and Centro de Investigação e Formação Clinica, Pediatric Hospital, Centro Hospitalar e Universitário de Coimbra, Coimbra, 3041-80, Portugal, University Clinic of Pediatrics and Institute for Biomedical Imaging and Life Science, Faculty of Medicine, University of Coimbra, Coimbra, 3041-80, Portugal. Eftichia Duketis, Affiliation/s: Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, JW Goethe University Frankfurt, Frankfurt am Main, 60528, Germany. Richard Delorme, Affiliation/s: FondaMental Foundation, Créteil, 94000, France, Human Genetics and Cognitive Functions Unit, Institut Pasteur, Paris, 75015, France, Centre National de la Recherche Scientifique URA 2182 Institut Pasteur, Paris, 75724, France, Department of Child and Adolescent Psychiatry, Robert Debré Hospital, Assistance Publique – Hôpitaux de Paris, Paris, 75019, France, Silvia DeRubeis, Affiliation/s: Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Maretha V DeJonge, Affiliation/s: Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, 3584 CG, The Netherlands. Geraldine Dawson, Affiliation/s: Duke Center for Autism and Brain Developments, Duke University School of Medicine, Durham, NC 27705, USA, Duke Institute for Brain Sciences, Duke University School of Medicine, Durham, NC 27708, USA. Michael L Cuccaro, Affiliation/s: The John P Hussman Institute for Human Genomics, University of Miami, Miami, FL 33101, USA. Catarina T Correia, Affiliation/s: Instituto Nacional de Saúde Dr Ricardo Jorge, Lisboa, 1600, Portugal, Center for Biodiversity, Functional and Integrative Genomics, Campus da FCUL, Lisboa, 1649, Portugal. Judith Conroy, Affiliation/s: Academic Centre on Rare Diseases, University College Dublin, Dublin, D4, Ireland, Temple Street Children ’ s University Hospital, Dublin, D1, Ireland. Ines C Conceição, Affiliation/s: Instituto Nacional de Saúde Dr Ricardo Jorge, Lisboa, 1600, Portugal, Center for Biodiversity, Functional and Integrative Genomics, Campus da FCUL, Lisboa, 1649, Portugal. Andreas G Chiocchetti, Affiliation/s: Depar tment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, JW Goe the University Frankfurt, Frankfurt am Main, 60528, Germany. Patrícia BS Celestino-Soper, Affiliation/s: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA, Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indian- apolis, IN 46202, USA. Jillian Casey, Affiliation/s: Temple Street Children ’ s University Hospital, Dublin, D1, Ireland, Academic Centre on Rare Diseases, University College Dublin, Dublin, D4, Ireland. Rita M Cantor, Affiliation/s: Department of Psychiatry, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA, Department of Human Genetics, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA. Cátia Café, Affiliation/s: Unidade de Neurodesenvolvimento e Autismo do Serviço do Centro de Desenvolvimento da Criança and Centro de Investigação e Formação Clinica, Pediatric Hospital, Centro Hospitalar e Universitário de Coimbra, Coimbra, 3041-80, Portugal. Jonas Bybjerg-Grauholm, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, DK-2300, Denmark. Sean Brennan, Affiliation/s: Department of Psychiatry, Trinity College Dublin, Dublin, D8, Ireland. Thomas Bourgeron, Affiliation/s: FondaMental Foundation, Créteil, 94000, France, University Paris Diderot, Sorbonne Paris Cité, Paris, 75013, France, Patrick F Bolton, Affiliation/s: Institute of Psychiatry, Kings College London, London, SE5 8AF, UK, South London and Maudsley Biomedical Research Centre for Mental Health, London, SE5 8AF, UK. Sven Bölte, Affiliation/s: Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, JW Goethe University Frankfurt, Frankfurt am Main, 60528, Germany, Department of Women ’ s and Children ’ s Health, Center of Neurodevelopmental Disorders, Karolinska Institutet, Stockholm, SE- 113 30, Sweden, Child and Adolescent Psychiatry, Center for Psychiatry Re- search, Stockholm County Council, Stockholm, SE-171 77, Sweden. Nadia Bolshakova, Affiliation/s: Department of Psychiatry, Trinity College Dublin, Dublin, D8, Ireland. Catalina Betancur, Affiliation/s: INSERM U1130, Paris, 75005, France, CNRS UMR 8246, Paris, 75005, France, Sorbonne Universités, UPMC Univ Paris 6, Neuroscience Paris Seine, Paris, 75005, France. Raphael Bernier, Affiliation/s: Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA. Arthur L Beaudet, Affiliation/s: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA. Agatino Battaglia, Affiliation/s: Stella Maris Institute for Child and Adolescent Neuropsychiatr, Pisa, 56018, Italy. Vanessa H Bal, Affiliation/s: Department of Psychiatry, University of California San Francisco, San Francisco, CA 94143, USA. Gillian Baird, Affiliation/s: Paediatric Neurodisability, King ’ s Health Partners, Kings College London, London, SE1 7EH, UK. Anthony J Bailey, Affiliation/s: Department of Psychiatry, University of Oxford and Warneford Hospital, Oxford, OX3 7JX, UK, Mental Health and Addictions Research Unit, University of British Colombia, Vancouver, BC, V5Z 4H4, Canada. Marie Bækvad-Hansen, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, DK-2300, Denmark. Joel S Bader, Affiliation/s: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD 21218, USA. Elena Bacchelli, Affiliation/s: Department of Pharmacy and Biotechnology, University of Bologna, Bologna, 40126, Italy. Evdokia Anagnostou, Affiliation/s: Bloorview Research Institute, University of Toronto, Toronto, ON, M4G 1R8, Canada. David Amaral, Affiliation/s: The MIND Institute, School of Medicine, University of California Davis, Davis, CA 95817, USA, Department of Psychiatry, School of Medicine, University of California Davis, Davis, CA 95817, USA, Department of Behavioural Sciences, School of Medicine, University of California Davis, Davis, CA 95817, USA. Joana Almeida, Affiliation/s: Unidade de Neurodesenvolvimento e Autismo do Serviço do Centro de Desenvolvimento da Criança and Centro de Investigação e Formação Clinica, Pediatric Hospital, Centro Hospitalar e Universitário de Coimbra, Coimbra, 3041-80, Portugal. Anders D Børglum, Affiliation/s: iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark, Department of Biomedicine - Human Genetics, Aarhus University, Aarhus, DK-8000, Denmark. Joseph D Buxbaum, Affiliation/s: Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA Aravinda Chakravarti, Affiliation/s: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD 21218, USA. Edwin H Cook, Affiliation/s: Institute for Juvenile Research, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA. Hilary Coon, Affiliation/s: Department of Psychiatry, University of Utah, Salt Lake City, UT 84108, USA. Daniel H Geschwind, Affiliation/s: Center for Autism Research and Treatment, Semel Institute, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA, Center for Neurobehavioral Genetics, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA, Department of Human Genetics, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA, Michael Gill, Affiliation/s: Department of Psychiatry, Trinity College Dublin, Dublin, D8, Ireland. Hakon Hakonarson, Affiliation/s: The Center for Applied Genomics and Division of Human Genetics, Children ’ s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA, Dept of Pediatrics, University of Pennsylvania, Philadelphia, PA 19104, USA. Joachim Hallmayer, Affiliation/s: Department of Psychiatry, Stanford University, Stanford, CA 94305, USA. Aarno Palotie, Affiliation/s: Sanger Institute, Hinxton, CB10 1SA, UK., Anney, Richard J. L., Ripke, Stephan, Anttila, Verneri, Grove, Jakob, Holmans, Peter, Huang, Hailiang, Klei, Lambertu, Lee, Phil H., Medland, Sarah E., Neale, Benjamin, Robinson, Elise, Weiss, Lauren A., Zwaigenbaum, Lonnie, Yu, Timothy W., Wittemeyer, Kerstin, Willsey, A. Jeremy, Wijsman, Ellen M., Werge, Thoma, Wassink, Thomas H., Waltes, Regina, Walsh, Christopher A., Wallace, Simon, Vorstman, Jacob A. S., Vieland, Veronica J., Vicente, Astrid M., Vanengeland, Herman, Tsang, Kathryn, Thompson, Ann P., Szatmari, Peter, Svantesson, Oscar, Steinberg, Stacy, Stefansson, Kari, Stefansson, Hreinn, State, Matthew W., Soorya, Latha, Silagadze, Teimuraz, Scherer, Stephen W., Schellenberg, Gerard D., Sandin, Sven, Sanders, Stephan J., Saemundsen, Evald, Rouleau, Guy A., Rogã©, Bernadette, Roeder, Kathryn, Roberts, Wendy, Reichert, Jennifer, Reichenberg, Abraham, Rehnstrã¶m, Karola, Regan, Regina, Poustka, Fritz, Poultney, Christopher S., Piven, Joseph, Pinto, Dalila, Pericak-Vance, Margaret A., Pejovic-Milovancevic, Milica, Pedersen, Marianne Giørtz, Pedersen, Carsten Bøcker, Paterson, Andrew D., Parr, Jeremy R., Pagnamenta, Alistair T., Oliveira, Guiomar, Nurnberger, John I., Nordentoft, Merete, Murtha, Michael T., Mouga, Susana, Mortensen, Preben Bo, Mors, Ole, Morrow, Eric M., Moreno-De-Luca, Daniel, Monaco, Anthony P., Minshew, Nancy, Merikangas, Alison, Mcmahon, William M., Mcgrew, Susan G., Mattheisen, Manuel, Martsenkovsky, Igor, Martin, Donna M., Mane, Shrikant M., Magnusson, Pall, Magalhaes, Tiago, Maestrini, Elena, Lowe, Jennifer K., Lord, Catherine, Levitt, Pat, Martin, Christa Lese, Ledbetter, David H., Leboyer, Marion, Lecouteur, Ann S., Ladd-Acosta, Christine, Kolevzon, Alexander, Klauck, Sabine M., Jacob, Suma, Iliadou, Bozenna, Hultman, Christina M., Hougaard, David M., Hertz-Picciotto, Irva, Hendren, Robert, Hansen, Christine Søholm, Haines, Jonathan L., Guter, Stephen J., Grice, Dorothy E., Green, Jonathan M., Green, Andrew, Goldberg, Arthur P., Gillberg, Christopher, Gilbert, John, Gallagher, Louise, Freitag, Christine M., Fombonne, Eric, Folstein, Susan E., Fernandez, Bridget, Fallin, M. Daniele, Ercan-Sencicek, A. Gulhan, Ennis, Sean, Duque, Frederico, Duketis, Eftichia, Delorme, Richard, Derubeis, Silvia, Dejonge, Maretha V., Dawson, Geraldine, Cuccaro, Michael L., Correia, Catarina T., Conroy, Judith, Conceiã§ã£o, Ines C., Chiocchetti, Andreas G., Celestino-Soper, Patrícia B. S., Casey, Jillian, Cantor, Rita M., Cafã©, Cã¡tia, Bybjerg-Grauholm, Jona, Brennan, Sean, Bourgeron, Thoma, Bolton, Patrick F., Bã¶lte, Sven, Bolshakova, Nadia, Betancur, Catalina, Bernier, Raphael, Beaudet, Arthur L., Battaglia, Agatino, Bal, Vanessa H., Baird, Gillian, Bailey, Anthony J., Bækvad-Hansen, Marie, Bader, Joel S., Bacchelli, Elena, Anagnostou, Evdokia, Amaral, David, Almeida, Joana, Bã¸rglum, Anders D., Buxbaum, Joseph D., Chakravarti, Aravinda, Cook, Edwin H., Coon, Hilary, Geschwind, Daniel H., Gill, Michael, Hallmayer, Joachim, Palotie, Aarno, Santangelo, Susan, Sutcliffe, James S., Arking, Dan E., Devlin, Bernie, Daly, Mark J., Hakonarson, Hakon, Génétique Humaine et Fonctions Cognitives, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Fondation FondaMental [Créteil], Génétique de l'autisme = Genetics of Autism (NPS-01), Neuroscience Paris Seine (NPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Michèle Darmon, Robert Gardette, Gabriel Gäta, Liliana Pardo-López, Lamia Achour, Seung-Kwon Yang, Stefano Marullo, M.B. Emerit, Stéphane Doly, Vincent Armand, Manuel Mameli, Hamasseh Shirvani, Hervé Enslen, Bernhard Bettler, Martin Gassmann, Bruno Giros, Frank J. Meye, Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut du Fer à Moulin, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de psychiatrie et neurosciences (U894 / UMS 1266), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Physiopathologie des Maladies du Système Nerveux Central, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service Psychiatrie, McGill University = Université McGill [Montréal, Canada]-Institut Universitaire en Santé Mentale Douglas, Department of Biomedicine, University of Basel (Unibas), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Transduction du Signal et Plasticite Dans Le Systeme Nerveux, Neurobiologie et Psychiatrie, University of Basel, Department of Biomedicine, Laboratoire Nanotechnologies Nanosystèmes (LN2 ), Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-École Centrale de Lyon (ECL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Sherbrooke (UdeS)-École supérieure de Chimie Physique Electronique de Lyon (CPE)-Centre National de la Recherche Scientifique (CNRS), [Institut Cochin] Département Endocrinologie, métabolisme, diabète (EMD) (EMD), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de Psychiatrie et Neurosciences (U894), Bos, Mireille, Université de Sherbrooke (UdeS)-École Centrale de Lyon (ECL), Université de Lyon-Université de Lyon-École Supérieure de Chimie Physique Électronique de Lyon (CPE)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Neurobiologie de l'apprentissage, de la mémoire et de la communication (NAMC), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Nanotechnologies Nanosystèmes (LN2), Université de Sherbrooke [Sherbrooke]-École Centrale de Lyon (ECL), Université de Lyon-Université de Lyon-École supérieure de Chimie Physique Electronique de Lyon (CPE)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Institut Cochin ( UM3 (UMR 8104 / U1016) ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre de Psychiatrie et Neurosciences ( CPN - U894 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), McGill University-Institut Universitaire en Santé Mentale Douglas, and University of Basel ( Unibas )

Susanne Lucae, Gerhard Schratt, M.P. Schwarz, Adam Wright, Martin Hautzinger, Philip B. Mitchell, Sharof Khudayberdiev, Nicholas G. Martin, W. Maier, Johannes Schumacher, Piotr M. Czerski, Markus M. Nöthen, Janice M. Fullerton, Susanne Meier, Cristiana Cruceanu, Tim Becker, Jana Strohmaier, Peter R. Schofield, Stefan Herms, Guy A. Rouleau, André Lacour, Thomas G. Schulze, Sugirthan Sivalingam, Galina Pantelejeva, Gustavo Turecki, Elza Khusnutdinova, Lilia I. Abramova, Catherine Laprise, Fermín Mayoral, Stephanie H. Witt, Jens Treutlein, Joanna Hauser, James D. McKay, Sven Cichon, Martin Alda, Bertram Müller-Myhsok, Andreas Reif, Michael Bauer, Manuel Mattheisen, Franziska Degenhardt, Marcella Rietschel, Helmut Vedder, Peter Propping, Alexey Polonikov, Neonilia Szeszenia-Dabrowska, S. E. Medland, Scott D. Gordon, Markus Leber, Valery Krasnov, Lutz Priebe, Alexander Chuchalin, Susanne Moebus, Peter Hoffmann, Gulia Babadjanova, A Verhaert, Thomas W. Mühleisen, M Grigoroiu-Serbanescu, Jolanta Lissowska, Alexander S. Tiganov, Simon Sumer, Henning G. Schulz, Andreas Hofmann, Grant W. Montgomery, Paul Brennan, Anna Maaser, Andreas J. Forstner, Fabio Rivas, Manolis Kogevinas, Andrea Pfennig, Jutta Kammerer-Ciernioch, René Breuer, [Forsther,AJ, Hofmann,A, Maaser,A, Mühleisen,TW, Degenhardt,F, Schumacher,J, Herms,S, Hoffmann,P, Priebe,L, Sivalingam,S, Verhaert,A, Propping,P, Cichon,S, Nöthen,MM, ] Institute of Human Genetics, University of Bonn, Bonn, Germany. [Forsther,AJ, Nöthen,MM] Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany. [Sumer,S, Khudayberdiev,S, Schratt,G] Institute of Physiological Chemistry, Philipps-University Marburg, Marburg, Germany. [Mühleisen,TW, Cichon,S] Institute of Neuroscience and Medicine, Research Center Juelich, Juelich, Germany. [Leber,M, Becker,T] Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany. [Schulze,TG] Institute of Psychiatric Phenomics and Genomics, Ludwig-Maximilians-University Munich, Munich, Germany. [Strohmaier,J, Treutlein,J, Breuer,R, Meier,S, Witt,SH, Rietschel,M] Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Heidelberg, Germany. [Mattheisen,M] Department of Biomedicine, Aarhus University, Aarhus, Denmark. Institute for Genomics Mathematics, University of Bonn, Bonn, Germany. [Meier,S] National Center Register-Based Research, Aarhus University, Aarhus, Denmark. [Herms,S, Cichon,S] Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland. [Lacour,A] German Center for Neurodegenerative Diseases, Bonn, Germany. [Reif,A] Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt am Main, Frankfurt, Germany. [Müller-Myhsok,B, Lucae,S] Max Planck Institute of Psychiatry, Munich, Germany. [Müller-Myhsok,B ] Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. University of Liverpool, Institute of Translational Medicine, Liverpool, UK. [Maier,W] Department of Psychiatry, University of Bonn, Bonn, Germany. [Schwarz,M, Vedder,H] Psychiatric Center Nordbaden, Wiesloch, Germany. [Kammerer-Ciernioch,J] Center of Psychiatry Weinsberg, Weinsberg, Germany. [Pfennig,A, Bauer,M] Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany. [Hautzinger,M] Department of Psychology, Clinical Psychology and Psychotherapy, Eberhard Karls University Tübingen, Tübingen, Germany. [Moebus,S] Institute of Medical Informatics, Biometry and Epidemiology, University Duisburg-Essen, Essen, Germany. [Shultz,H] Cologne Center for Genomics, University of Cologne, Cologne, Germany. [Czerski,PM, Hauser,J] Department of Psychiatry, Laboratory of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland. [Lossowska,J] Department of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology Warsaw, Warsaw, Poland. [Szeszenia-Dabrowska,N] Department of Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland. [Brennan,P] Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France. [Mckay,JD] Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, Lyon, France. [Wright,A, Mitchell,PB] School of Psychiatry, University of New South Wales, Randwick, NSW, Australia. Black Dog Institute, Prince of Wales Hospital, Randwick, NSW, Australia. [Fullerton,JM, Schofield,PR] Neuroscience Research Australia, Sydney, NSW, Australia. School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia. [Montgomery,GW, Medland,SE, Gordon,SD, Martin, NG] Queensland Institute of Medical Research, Brisbane, QLD, Australia. [Krasnov ,V] Moscow Research Institute of Psychiatry, Moscow, Russian Federation. [Chuchalin,A, Babadjanova,G] Institute of Pulmonology, Russian State Medical University, Moscow, Russian Federation. [Pantelejeva,G, Abramova,LI, Toganoc,AS] Russian Academy of Medical Sciences, Mental Health Research Center, Moscow, Russian Federation. [Polonikov,A] Department of Biology, Medical Genetics and Ecology, Kursk State Medical University, Kursk, Russian Federation. [Khusnutdinova,E] Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russian Federation. Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Russian Federation. [Alda,M] Department of Psychiatry, Dalhousie University, Halifax, NS, Canada. National Institute of Mental Health, Klecany, Czech Republic. [Cruceanu,C, Rouleau,GA] Montreal Neurological Institute, McGill University, Montreal, QC, Canada. [Cruceanu,C, Turecki,G] Department of Human Genetics, McGill University, Montreal, QC, Canada. McGill Group for Suicide Studies and Douglas Research Institute, Montreal, QC, Canada. [Turecki,G] Department of Psychiatry, McGill University, Montreal, QC, Canada. [Laprise,C] Département des sciences fondamentales, Université du Québec à Chicoutimi (UQAC), Chicoutimi, QC, Canada. [Rivas,F, Mayoral,F] Department of Psychiatry, Hospital Regional Universitario, Biomedical Institute of Malaga, Malaga, Spain. [Kogevinas,M] Center for Research in Environmental Epidemiology, Barcelona, Spain. [Grigoroiu-Serbanescu,M] Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania., The study was supported by the German Federal Ministry of Education and Research (BMBF) through the Integrated Network IntegraMent (Integrated Understanding of Causes and Mechanisms in Mental Disorders), under the auspices of the e:Med Programme (grant 01ZX1314A to MMN and SC, grant 01ZX1314G to MR, grant 01ZX1314J to BMM), and through e:AtheroSysMed (Systems medicine of myocardial infarction and stroke, grant 01ZX1313B to BMM). MMN is a member of the DFGfunded Excellence-Cluster ImmunoSensation. MMN also received support from the Alfried Krupp von Bohlen und Halbach-Stiftung. The study was supported by the German Research Foundation (DFG, grant FOR2107, RI908/11-1 to MR, SCHR1136/3-1 to GS, and NO246/10-1 to MMN). MG-S received the grant no. 89/2012 from UEFISCDI, Romania. Canadian patients were genotyped within the ConLiGen project (www. ConLiGen.org), with the support of a grant from the Deutsche Forschungsgemeinschaft to MR, MB and TGS (RI 908/7-1). Controls for Germany II were drawn from the Heinz Nixdorf Recall Study (HNR) cohort, which was established with the support of the Heinz Nixdorf Foundation. Recruitment of the Australian sample was supported by an Australian NHMRC program grant (number 1037196). The recruitment of the Canadian patients was supported by a grant from the Canadian Institutes of Health Research #64410 to MA. The study also used data generated by the GABRIEL consortium (controls for the sample Russia). Funding for the generation of these data was provided by the European Commission as part of GABRIEL contract number 018996 under the Integrated Program LSH-2004-1.2.5-1. Post-genomic approaches to understand the molecular basis of asthma aiming at a preventive or therapeutic control and the Wellcome Trust under award 084703. Canadian controls were drawn from the French Canadian study (SLSJ), which was supported in part by the Canada Research Chair Environment and genetics of respiratory diseases and allergy, the Canadian Institutes of Health Research (Operating grant No. MOP-13506) and the Quebec Respiratory Network of the Fonds de recherche en Santé du Québec (FRQS). Polish controls were recruited by the International Agency for Research on Cancer (IARC)/Centre National de Genotypage (CNG) GWAS Initiative.

Thomas Rolland, Freddy Cliquet, Richard J.L. Anney, Clara Moreau, Nicolas Traut, Alexandre Mathieu, Guillaume Huguet, Jinjie Duan, Varun Warrier, Swan Portalier, Louise Dry, Claire S. Leblond, Elise Douard, Frédérique Amsellem, Simon Malesys, Anna Maruani, Roberto Toro, Anders D. Børglum, Jakob Grove, Simon Baron-Cohen, Alan Packer, Wendy K. Chung, Sébastien Jacquemont, Richard Delorme, Thomas Bourgeron, Génétique humaine et fonctions cognitives - Human Genetics and Cognitive Functions (GHFC (UMR_3571 / U-Pasteur_1)), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Cardiff University, Centre de Recherches Interdisciplinaires (CRI), Université Paris Cité (UPCité), Université de Montréal (UdeM), Centre de recherche du CHU Sainte-Justine / Research Center of the Sainte-Justine University Hospital [Montreal, Canada], Université de Montréal (UdeM)-CHU Sainte Justine [Montréal], The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Center for Genomics and Personalized Medicine [Aarhus, Denmark] (CGPM), Department of Biomedicine, Aarhus University, Autism Research Centre [Cambridge, Royaume-Uni], University of Cambridge [UK] (CAM), Service psychiatrique de l'enfant et de l'adolescent [CHU Hôpital Robert Debré], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré, Bioinformatics Research Centre, Aarhus University, Simons Foundation, Columbia University Medical Center (CUMC), Columbia University [New York], This work was funded by Institut Pasteur, the Bettencourt-Schueller Foundation, Université de Paris, the Conny-Maeva Charitable Foundation, the Cognacq Jay Foundation, the Eranet-Neuron (ALTRUISM), the GenMed Labex, AIMS-2-TRIALS which received support from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 777394 and the Inception program (Investissement d’Avenir grant ANR-16-CONV-0005). This project has received funding from the European Union’s Horizon 2020 research and innovative program CANDY under grant agreement No 847818., and ANR-16-CONV-0005,INCEPTION,Institut Convergences pour l'étude de l'Emergence des Pathologies au Travers des Individus et des populatiONs(2016)

Emma B. Hodcroft, Jan Albert, Randy Poelman, Diego García-Martínez de Artola, Elke Wollants, Marijke Reynders, Cristina Andrés, Josiane Reist, Hubert G. M. Niesters, Adrian Egli, Robert Dyrdak, Julia Alcoba Florez, Richard A. Neher, Andrés Antón, Microbes in Health and Disease (MHD), Institut Català de la Salut, [Hodcroft EB] Biozentrum, University of Basel, Basel, Switzerland. Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland. Swiss Institute of Bioinformatics, Basel, Switzerland. [Dyrdak R] Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden. Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden. [Andrés C, Antón A] Unitat de Virus Respiratoris, Secció de Virologia, Servei de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Egli A, Reist J] Clinical Bacteriology and Mycology, University Hospital Basel, Basel, Switzerland. Applied Microbiology Research, Department of Biomedicine, University of Basel, Basel, Switzerland. [García Martínez de Artola D] Department of Clinical Microbiology, Hospital Universitario Nuestra Señora de Candelaria, Tenerife, Spain, and Vall d'Hebron Barcelona Hospital Campus

Chiranjeevi Bodda, Søren B. Jensen, Carsten Scavenius, Anne Troldborg, Christine Doucet, Cheng long Sun, Ramya Nandakumar, Anders Laustsen, Thaneas Prabakaran, Zong liang Gao, Samuel J. Windross, Harald Stenmark, Zheng Guo, Line S. Reinert, Sonia Assil, Rune Hartmann, Søren R. Paludan, Jinrong Huang, Martin K. Thomsen, Yan Zhang, Ryo Narita, Jan J. Enghild, Bao cun Zhang, Zhijian J. Chen, Raphaela Goldbach-Mansky, Takeshi Noda, David Olagnier, Rasmus O. Bak, Cong gang Zhang, Martin F. Berthelsen, Yujia Cai, Department of Biomedicine Aarhus, Department of Clinical Medicine (Aarhus University), Department of Chemistry and Interdisciplinary Nanoscience Center, Aarhus University, Department of Molecular Biology, University of Aarhus, Institute for Cancer Research [Oslo], Oslo University Hospital [Oslo], Centre de Biochimie Structurale [Montpellier] (CBS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Graduate School of Frontier Biosciences [Osaka], Osaka University [Osaka], National Institute of Allergy and Infectious Diseases [Bethesda] (NIAID-NIH), National Institutes of Health [Bethesda] (NIH), The Novo Nordisk Foundation (NNF18OC0030274) and the Lundbeck Foundation (R198-2015-171, R268-2016-3927), B.-c.Z. is funded by a postdoctoral grant from the Danish Council for Independent Research, Medical Sciences (5053-00083B), the postdoctoral salary to S.A. was funded by the European Union under the Horizon 2020 Research and Innovation Program and Marie Skłodowska-Curie Actions (MSCA) – international fellowship (PathAutoBio 796840), the PhD scholarship to S.J.W. was funded by the European Union under the Horizon 2020 Research and Innovation Program and the MSCA-Innovative Training Networks Programme MSCA-ITN (EDGE, 675278), the postdoctoral grant to A.T. was funded by the Lundbeck Foundation (R264-2017-3344)., and European Project: 786602,ENVISION

F. Dalin, M. Domberg, C Stenlund, Mikael Hedeland, Ulf Bondesson, Lena Ström, Carl Ekstrand, Pierre-Louis Toutain, Swedish University of Agricultural Sciences (SLU), National Veterinary Institute [Uppsala] (SVA), Department of Medicinal Chemistry, Uppsala University, Sweden, Uppsala University, Innovations Thérapeutiques et Résistances (InTheRes), Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), The Royal Veterinary College, University of London, Hawkshead Campus, Hatfield AL9 7TA, UK., and Department of Biomedicine and Veterinary Public Health

Lozano-Chacon, Blanca, Suarez-Lledo, Victor, Alvarez-Galvez, Javier, [Lozano-Chacon,B, Suarez-Lledo,V, Alvarez-Galvez,J] Computational Social Science DataLab (CS2 DataLab), University Institute for Social Sustainable Development (INDESS), University of Cadiz, Cádiz, Spain. [Suarez-Lledo,V, Alvarez-Galvez,J] Department of Biomedicine, Biotechnology, and Public Health, University of Cadiz, Cádiz, Spain. [Alvarez-Galvez,J] Institute of Research and Innovation in Biomedical Research of Cadiz (INIBICA), University of Cadiz, Jerez de la Frontera, Spain., and J.A.-G. was supported by the Ramon & Cajal Programme (RYC-2016-19353), which is aimed at promoting the incorporation of national and foreign researchers with an outstanding career in R&D centers. This Programme is operated by the Ministry of Science and Innovation, and the European Social Fund.

Marta Ribasés, Christian Fadeuilhe, Josep Antoni Ramos-Quiroga, Lorena Arribas, Montserrat Corrales, Alejandro Arias-Vasquez, Cristina Sánchez-Mora, Silvia Karina Rosales-Ortiz, María Soler-Artigas, Vanesa Richarte, Estela Camus Garcia, Laura Vilar-Ribó, Institut Català de la Salut, [Richarte V, Corrales M, Fadeuilhe C] Grup de Recerca en Psiquiatria, Salut Mental i Addiccions, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain. Departament de Psiquiatria i Medicina Legal, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Sánchez-Mora C, Vilar-Ribó L] Grup de Recerca en Psiquiatria, Salut Mental i Addiccions, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain. Unitat de Genètica Psiquiàtrica, Grup de Psiquiatria, Salut Mental i Addiccions, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Arribas L] Grup de Recerca en Psiquiatria, Salut Mental i Addiccions, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Unitat de Genètica Psiquiàtrica, Grup de Psiquiatria, Salut Mental i Addiccions, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Garcia E] Unitat de Genètica Psiquiàtrica, Grup de Psiquiatria, Salut Mental i Addiccions, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Rosales-Ortiz SK] Unitat de Genètica Psiquiàtrica, Grup de Psiquiatria, Salut Mental i Addiccions, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Department of Biomedicine, University of Barcelona, Barcelona, Spain. [Soler-Artigas M, Ribasés M] Grup de Recerca en Psiquiatria, Salut Mental i Addiccions, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain. Unitat de Genètica Psiquiàtrica, Grup de Psiquiatria, Salut Mental i Addiccions, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Department of Genetics, Microbiology & Statistics, University of Barcelona, Barcelona, Spain. [Ramos-Quiroga JA] Grup de Recerca en Psiquiatria, Salut Mental i Addiccions, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain. Departament de Psiquiatria i Medicina Legal, Universitat Autònoma de Barcelona, Bellaterra, Spain. Unitat de Genètica Psiquiàtrica, Grup de Psiquiatria, Salut Mental i Addiccions, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain, and Vall d'Hebron Barcelona Hospital Campus

Enrique Aguado, Ewoud B. Compeer, Arkadiusz Miazek, [Aguado,E] Institute of Biomedical Research Cadiz (INIBICA), Cádiz, Spain. [Aguado,E] Department of Biomedicine, Biotechnology and Public Health (Immunology), University of Cádiz, Cádiz, Spain. [Compeer,EB] Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom. [Miazek,A] Department of Biochemistry and Molecular Biology, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland., and EA was funded by the Consejería de Salud de Andalucía, Junta de Andalucía (Grant PI-0055-2017 to EA), and Fundación Biomédica Cádiz Proyectos INIBICA 2019 (Grant LI19/I14NCO15). EBC was supported by John Fell Fund, and ERC AdG 670930 to Michael Dustin. AM was funded by the Leading Research Groups Support project obtained in 2019 (with the subsidy, increased for the period 2020–2025 in the amount of 2% of the subsidy referred to Art. 387 (3) of the Law of 20 July 2018 on Higher Education and Science, Poland).

Frank Barry, Ivan Martin, Thomas W. Bauer, Cecilia Pascual-Garrido, Christian Jorgensen, Scott A. Rodeo, George F. Muschler, Constance R. Chu, Jérôme Guicheux, Pamela Gehron Robey, Nicolas S. Piuzzi, Massimo Dominici, Stéphane Maddens, M. A.R.C. Long, J. O.H.N. Barrett, David Karli, Richard McFarland, Johnny Huard, Laurie R. Goodrich, Daniel J. Weiss, Department of Orthopedic Surgery [Cleveland, Ohio, USA], Cleveland Clinic, Instituto Universitario del Hospital Italiano [Buenos Aires, Argentina], Department of Medical and Surgical Sciences for Children and Adults [Modena, Italy] (Laboratory of Cellular Therapy), Università degli Studi di Modena e Reggio Emilia (UNIMORE), MTF Biologics, Edison [New Jersey, USA], Adult Reconstruction-Adolescent and Young Adult Hip Service [St. Louis, Missouri, USA] (School of Medicine), Washington University in Saint Louis (WUSTL), Orthopaedic Soft Tissue Research Program [New York, NY, USA], Hospital for Special Surgery, Department of Orthopaedic Surgery [Houston, TX, USA], The University of Texas Health Science Center at Houston (UTHealth), Steadman Philippon Research Institute, Regenerative Medicine and Skeleton research lab (RMeS), Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'Oto-Rhino-Laryngologie et de Chirurgie Cervico-Faciale [CHU Nantes] (PHU4 - OTONN), Centre hospitalier universitaire de Nantes (CHU Nantes), Advanced Regenerative Manufacturing Institute [Manchester, NH, USA], Standards Coordinating Body, Department of Clinical Sciences [Fort Collins, CO, USA] (Orthopaedic Research Center), Colorado State University [Fort Collins] (CSU), Vetbiobank [Marcy l’Etoile, France], Department of Health and Human Services [Bethesda, MD, USA] (Skeletal Biology Section ), National Institutes of Health [Bethesda] (NIH), Department of Pathology and Laboratory Medicine [New-York, NY, USA], Stem Cell Allogeneic Transplant Section [Bethesda, MD, USA], Regenerative Medicine Institute [Galway, Ireland], National University of Ireland [Galway] (NUI Galway), Greyledge Technologies - LLC [Vail, CO, USA], Department of Orthopaedic Surgery [Stanford], Stanford Medicine, Stanford University-Stanford University, Veterans Affairs Palo Alto Health Care System [Palo Alto, CA, USA], University of Vermont [Burlington], Department of Biomedicine [Basel], University Hospital Basel [Basel], Unité thérapeutique d'immunologie clinique et des maladies ostéoarticulaires [Hôpital Lapeyronie, Montpellier], Hôpital Lapeyronie [Montpellier] (CHU), The authors thanks both the ISCT and the sponsors of the First Signature Series Symposium 'Cellular Therapies for Orthopaedics and Musculoskeletal Disease Proven and Unproven Therapies–Promise, Facts and Fantasy,' May 2, 2018, Montreal, Canada: Greyledge Technologies (Edwards, Colorado), MTF Biologics (Edison, New Jersey), Orthofix (Lewisville, Texas), MEdXcell (Lausanne, Switzerland), Osiris Therapeutics (Columbia, Maryland) and Angiocrine Bioscience (San Diego, California). Additionally this work was supported, in part, by the DIR, NIDCR, a part of the Intramural Research Program (IRP), NIH, DHHS (to P.G.R., ZIA DE000380)., Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), Regenerative Medicine and Skeleton (RMeS), École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Jehan, Frederic, Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), and University of Vermont College of Medicine [Burlington, VT, USA]

Aranzazu Quiroga-de-Castro, Alfonso M. Lechuga-Sancho, Antonia Diaz-Ganete, Carmen Segundo, Rosa M. Mateos, Francisco Medina, Biomedicina, Biotecnología y Salud Pública, Materno-Infantil y Radiología, [Diaz-Ganete,A, Mateos,RM, Medina,F, Segundo,C, Lechuga-Sancho,AM] Inflammation, Nutrition, Metabolism and Oxidative Stress Study Group (INMOX), Biomedical Research and Innovation Institute of Cádiz (INiBICA), Research Unit, Puerta del Mar University Hospital, Cádiz, Spain. [Quiroga-de-Castro,A, Lechuga-Sancho,AM] Area of Pediatrics, Department of Child and Mother Health and Radiology, Medical School, University of Cádiz, Cádiz, Spain. [Mateos,RM] Area of Biochemistry and Molecular Biology, Department of Biomedicine, Biotechnology and Public Health, University of Cádiz, Cádiz, Spain. [Medina,F, Segundo,C] Salus Infirmorum Faculty of Nursing, Cadiz University, Cadiz, Spain. [Lechuga-Sancho,AM] Pediatric Endocrinology, Department of Pediatrics, Puerta del Mar University Hospital, Cádiz, Spain., and This research was funded by grants by the Andalusian Department of Health (PI 0765-2011 and PI-0269-2014) to A.M.L.-S. A.D.-G. was funded by an intramural grant from the Foundation for Biomedical Research in Cadiz.

Arkadiusz Miazek, Enrique Aguado, Inmaculada Vico-Barranco, Alba Pérez-Linaza, Isaac Narbona-Sánchez, Mikel M Arbulo-Echevarria, Jose Maria Miranda-Sayago, Isabel Serrano-García, Biomedicina, Biotecnología y Salud Pública, [Vico-Barranco,I, Arbulo-Echevarria,MM, Miranda-Sayago,JM, Narbona-Sánchez,I, Aguado,E] Institute of Biomedical Research Cadiz (INIBICA), Cádiz, Spain. [Serrano-García,I, Pérez-Linaza,A] Rheumatology Section, Unit of Orthopedic Surgery, Traumatology and Rheumatology, HUPM, Cádiz, Spain. [Miazek,A] Department of Biochemistry and Molecular Biology, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland. [Aguado,E] Department of Biomedicine, Biotechnology and Public Health (Immunology), Universidad de Cádiz,Cádiz, Spain., and This research was funded by Consejería de Salud de Andalucía, Junta de Andalucía (grant PI-0055-2017 to E.A.), and Fundación Biomédica Cádiz Proyectos INIBICA 2019 (grant LI19/I14N CO15 to E.A. and M.M.A.-E.).

[Carvajal S, Perramón M, Oró D] Biochemistry and Molecular Genetics Service, Hospital Clínic Universitari, IDIBAPS, Barcelona, Spain. Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas (CIBEREHD), Madrid, Spain. [Casals E] School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, China. [Fernández-Varo G] Biochemistry and Molecular Genetics Service, Hospital Clínic Universitari, IDIBAPS, Barcelona, Spain. Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas (CIBEREHD), Madrid, Spain. Department of Biomedicine, University of Barcelona, Barcelona, Spain. [Casals G] Biochemistry and Molecular Genetics Service, Hospital Clínic Universitari, IDIBAPS, Barcelona, Spain. Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas (CIBEREHD), Madrid, Spain. Working group for the biochemical assessment of hepatic disease-SEQCML, Barcelona, Spain. [Puntes V] Institut Català de Recerca i Estudis Avançats, (ICREA), Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Institut Català de Nanociència i Nanotecnologia (ICN2), Universitat Autònoma de Barcelona, Bellaterra, Spain and Hospital Universitari Vall d'Hebron

Paolo Nuciforo, Domenica Marchese, Carlota Rubio-Perez, Juan L. Trincado, Juan Sahuquillo, Josep Tabernero, Estela Pineda, Ester Bonfill-Teixidor, Holger Heyn, Francisco Martínez-Ricarte, Josep Maria Mesquida González, Genís Parra, Sara Ruiz, Leire Pedrosa, Marta Cicuendez, Joan Seoane, Catia Moutinho, Garazi Serna, Ester Planas-Rigol, Esteban Cordero, Laura Escudero, Alexandra Arias, Raffaella Iurlaro, Institut Català de la Salut, [Rubio-Perez C, Planas-Rigol E, Bonfill-Teixidor E, Arias A, Serna G, Iurlaro R, Escudero L, Nuciforo P] Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Trincado JL] CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain. Josep Carreras Leukemia Research Institute and Department of Biomedicine, School of Medicine, University of Barcelona, Barcelona, Spain. [Marchese D] CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain. [Martínez-Ricarte F, Cordero E, Cicuendez M, Sahuquillo J] Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Tabernero J] Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. CIBERONC, Barcelona, Spain. [Seoane J] Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. CIBERONC, Barcelona, Spain. Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus

Valarcher, Jean, Hägglund, Sara, Näslund, Katarina, Jouneau, Luc, Malmström, Ester, Boulesteix, Olivier, Pinard, Anne, Leguéré, Dany, Deslis, Alain, Gauthier, David, Dubuquoy, Catherine, Pietralunga, Vincent, Remot, Aude, Falk, Alexander, Shevchenko, Ganna, Bergström Lind, Sara, Von Brömssen, Claudia, Vargmar, Karin, Zhang, Baoshan, Kwong, Peter, Rodriguez, María Jose, Garcia Duran, Marga, Schwartz-Cornil, Isabelle, Taylor, Geraldine, Riffault, Sabine, Department of Clinical Sciences, Swedish University of Agricultural Sciences (SLU), Virologie et Immunologie Moléculaires (VIM (UR 0892)), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Plateforme d'Infectiologie Expérimentale (PFIE), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Infectiologie et Santé Publique (UMR ISP), Université de Tours-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Department of Chemistry [Uppsala, Sueden], Biomedical Center = Biomedicinskt centrum [Uppsala, Sueden] (BMC), Uppsala University-Uppsala University, Department of Energy and Technology, Department of Biomedicine and Veterinary Public Health, Vaccine Research Center (VRC), National Institutes of Health [Bethesda] (NIH), INGENASA, Institute for Animal Health, the Pirbright Institute, Swedish Foundation of Strategic Research (SB16-0039), Intramural Research Program of the Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH) (USA), European Project: 633184,H2020,H2020-SFS-2014-2,SAPHIR(2015), Université de Tours (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), The Pirbright Institute, and Biotechnology and Biological Sciences Research Council (BBSRC)

Antonio J Medina-Olivera, José Manuel Botubol-Ares, Marta Ferrera-Suanzes, Victoria Prieto, Fátima Galán-Sánchez, Rosario Hernández-Galán, María Jesús Durán-Peña, Manuel Rodríguez-Iglesias, Biomedicina, Biotecnología y Salud Pública, Química Orgánica, [Ferrera-Suanzes,M, Medina-Olivera,AJ, Botubol-Ares,JM, Hernández-Galán,R, Durán-Peña,MJ] Department of Organic Chemistry, Faculty of Sciences, Campus Universitario Río San Pedro, University of Cádiz, Puerto Real, Cádiz, Spain. [Prieto,V, Galán-Sánchez,F, Rodríguez-Iglesias,MA] Department of Biomedicine, Biotechnology and Public Health, Hospital Puerta del Mar, University of Cádiz, Cádiz, Spain. [Galán-Sánchez,F, Rodríguez-Iglesias,MA, Hernández-Galán,R] Instituto de investigación e Innovación Biomédica de Cádiz (INIBICA), Cádiz, Spain., and We would like to thank the research programme ‘Programa de fomento e impulso de la investigación y la transferencia en la Universidad de Cádiz’ from University of Cádiz for the funding for this project PR2017-046.

Alfonso M. Lechuga-Sancho, Francisco Visiedo, Mateos Rosa M, Álvaro González-Domínguez, Celeste Santos-Rosendo, Fernando Bugatto, Biología, Biomedicina, Biotecnología y Salud Pública, Materno-Infantil y Radiología, [Santos-Rosendo,C] Department of Biology, University of Cádiz, Cádiz, Spain. [Bugatto,F, González-Domínguez,A, Lechuga-Sancho,AM, Mateos,MR, Visiedo,F] Inflammation, Nutrition, Metabolism and Oxidative Stress Study Group (INMOX), Biomedical Research and Innovation Institute of Cádiz (INiBICA), Research Unit, University Hospital 'Puerta del Mar', Cádiz, Spain. [Bugatto,F, and Lechuga-Sancho,AM] Area of Pediatrics, Department of Child and Mother Health and Radiology, Medical School, University of Cádiz, Cádiz, Spain. [Bugatto,F] Division of Fetal-Maternal Medicine, Department of Obstetrics and Gynecology, Puerta del Mar University Hospital, Cádiz, Spain. [Lechuga-Sancho,AM] Pediatric Endocrinology Unit, Department of Pediatrics, Puerta del Mar University Hospital, Cadiz, Spain. [Mateos,MR] Area of Biochemistry and Molecular Biology, Department of Biomedicine, Biotechnology and Public Health. University of Cádiz, Cádiz, Spain.

González-Domínguez, Álvaro, Visiedo-García, Francisco M., Domínguez-Riscart, Jesús, González-Domínguez, Raúl, Mateos, Rosa M., Lechuga-Sancho, Alfonso María, [González-Domínguez,A, Visiedo-García,FM, Mateos,RM, Lechuga-Sancho,AM] Inflammation, Nutrition, Metabolism and Oxidative Stress Study Group (INMOX), Biomedical Research and Innovation Institute of Cádiz (INiBICA), Research Unit, Puerta del Mar University Hospital, Cádiz, Spain. [Domínguez-Riscart,J, Lechuga-Sancho,AM] Pediatric Endocrinology, Department of Pediatrics, Puerta del Mar University Hospital, Cádiz, Spain. [González-Domínguez,R] Department of Chemistry, Faculty of Experimental Sciences, University of Huelva, Huelva, Spain. [Mateos,RM] Area of Biochemistry and Molecular Biology, Department of Biomedicine, Biotechnology and Public Health, University of Cádiz, Cádiz, Spain. [Lechuga-Sancho,AM] Area of Pediatrics, Department of Child and Mother Health and Radiology, Medical School, University of Cádiz, Cádiz, Spain., and This research was funded by Spanish Government through the Carlos III Health Institute (Sanitary Research Fund (FIS)), code PI18/01316. A G-D is supported by an intramural grant from the Biomedical Research and Innovation Institute of Cádiz (INiBICA), code LII19/16IN-CO24.

Christophe Bonny, Frédéric Magoulès, William Farin, Nicolas Pons, Florian Plaza Oñate, Bettina Woelnerhanssen, David Nocca, Christoph Beglinger, Alessandra C. L. Cervino, S. Dusko Ehrlich, Jonathan Plassais, Enterome, Université Paris-Saclay, Department of Biomedicine [Basel], University Hospital Basel [Basel], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Département de chirurgie digestive, [CHU Montpellier], CentraleSupélec, MetaGenoPolis (MGP (US 1367)), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre for Host-Microbiome Interactions, Dental Institute Central Office, and King‘s College London

Palma, José M., Mateos, Rosa M., López-Jaramillo, Javier, Rodríguez-Ruiz, Marta, González-Gordo, Salvador, Lechuga-Sancho, Alfonso M., Corpas, Francisco J., [Palma,JM, González-Gordo,S, Corpas,FJ] Group of Antioxidants, Free Radicals and Nitric Oxide in Biotechnology, Food and Agriculture, Dept. Biochemistry, Cell and Molecular Biology of Plants, Estación Experimental del Zaidín, CSIC, Granada, Spain. [Mateos,RM, Lechuga-Sancho,AM] Imflammation, Nutrition, Metabolism and Oxidative Stress Study Group (INMOX), Biomedical Research and Innovation Institute of Cádiz (INiBICA), Research Unit, Puerta del Mar University Hospital, Cádiz, Spain. [Mateos,RM] Area of Biochemistry and Molecular Biology, Department of Biomedicine, Biotechnology and Public Health, University of Cádiz, Cádiz, Spain. [López-Jaramillo,J] Instituto de Biotecnología, Universidad de Granada, Spain. [Rodríguez-Ruiz,M] Laboratório de Fisiologia do Desenvolvimiento Vegetal, Instituto de Biociências-Universidad de São Paulo, Cidade Universitária-São Paulo-SP, Brazil. [Lechuga-Sancho,AM] Department of Child and Mother Health and Radiology, Medical School, University of Cádiz, Cádiz, Spain., This work was supported by ERDF-cofinanced grants from the Ministry of Science and Innovation (AGL2015-65104-P and PID2019-103924GB-I00), the Plan Andaluz de Investigación, Desarrollo e Innovación (P18-FR-1359) and Junta de Andalucía (group BIO 192), Spain. Erythrocyte catalase study was funded within the Health Strategy Action (Spain’s National Plan for Science and Technology Research, Development and Innovation 2013–2016, and PI18-01316) and managed by the Carlos III National Institute of Health Carlos III.

Nathalie Auphan-Anezin, Marcello Delfini, Morgane Moulin, Toby Lawrence, Noushine Mossadegh-Keller, Anders Etzerodt, Søren K. Moestrup, Thomas Koed Doktor, Marc Bajénoff, Michael H. Sieweke, Department of Biomedicine, Aarhus University, Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), King‘s College London, University of Southern Denmark (SDU), Center of Regenerative Therapies Dresden, Technische Universität Dresden = Dresden University of Technology (TU Dresden), Xinxiang Medical University, Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense M, Denmark., and DUMENIL, Anita

Y Le Page, Denis Michel, Benjamin Boutin, Charly Jehanno, P. Le Goff, Gilles Flouriot, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Department of Biomedicine [Basel], University Hospital Basel [Basel], Institut de Recherche Mathématique de Rennes (IRMAR), AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-École normale supérieure - Rennes (ENS Rennes)-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), Ligue Contre le Cancer, Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École normale supérieure - Rennes (ENS Rennes)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-INSTITUT AGRO Agrocampus Ouest, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), and Michel, Denis

Fermín Mayoral, Fabio Rivas, Jesus Haro González, Franziska Degenhardt, Julian Hecker, Fermin Perez Perez, Marcella Rietschel, Michael Bauer, Margot Albus, Markus M. Nöthen, Sascha B. Fischer, Susana Gil Flores, Francisco del Río Noriega, Mehdi Pirooznia, Stefan Herms, Jana Strohmaier, Stephanie H. Witt, Fernando S. Goes, Margitta Borrmann-Hassenbach, Anna Maaser-Hecker, Sugirthan Sivalingam, Sven Cichon, Lorena M. Schenk, Georg Auburger, Andreas Reif, Fabian Streit, María González, Francisco J. Cabaleiro Fabeiro, Peter Nürnberg, Jose Guzman-Parra, Andreas J. Forstner, Holger Thiele, Guillermo Orozco Diaz, Andrea Pfennig, Céline S. Reinbold, Johannes Schumacher, Per Hoffmann, [Forstner,AJ, Schumacher,J] Centre for Human Genetics, University of Marburg, Marburg, Germany. [Forstner,AJ, Schenk,LM, Maaser-Hecker,A, Sivalingam,S, Degenhardt,F, Schumacher,J, Herms,S, Hoffmann,P, Nöthen,MM, Cichon,S] Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany. [Forstner,AJ, Fischer,SB, Reinbold,CS, Cichon,S] Department of Biomedicine, University of Basel, Basel, Switzerland. [Forstner,AJ] Department of Psychiatry (UPK), University of Basel, Basel, Switzerland. [Fischer,SB, Cichon,S] Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland. [Strohmaier,J, Streit,F, Witt,SH, Rietschel,M] Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. [Strohmaier,J] SRH University Heidelberg, Academy for Psychotherapy, Heidelberg, Germany. [Reinbold,CS] Center for Lifespan Changes in Brain and Cognition (LCBC), Department of Psychology, University of Oslo, Oslo, Norway. [Hecker,J] Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA. [Thiele,H, Nürnberg,P] Cologne Center for Genomics, University of Cologne, Cologne, Germany. [Guzman-Parra,J, González,MJ] Department of Mental Health, University Regional Hospital of Málaga, Institute of Biomedicine of Málaga (IBIMA), Málaga, Spain. [Orozco Diaz,G] Unidad de Gestión Clínica del Dispositivo de Cuidados Críticos y Urgencias del Distrito Sanitario Málaga - Coin- Gudalhorce, Málaga, Spain. [Auburger,G] Experimental Neurology, Department of Neurology, Goethe University Hospital, Frankfurt am Main, Germany. [Albus,M, Borrmann-Hassenbach,M]Isar Amper Klinikum München Ost, kbo, Haar, Germany. [Gil Flores,S] Department of Mental Health, University Hospital of Reina Sofia, Cordoba, Spain. [Cabaleiro Fabeiro,FJ] Department of Mental Health, Hospital of Jaén, Jaén, Spain. [del Río Noriega,F] Department of Mental Health, Hospital of Jerez de la Frontera, Jerez de la Frontera, Spain. [Perez Perez,F] Department of Mental Health, Hospital of Puerto Real, Cádiz, Spain. [Haro González,J] Department of Mental Health, Hospital Punta de Europa, Algeciras, Spain. [Rivas,F, Mayoral,F] Department of Psychiatry, Carlos Haya Regional University Hospital, Malaga, Spain. [Bauer,M, Pfennig,A] Department of Psychiatry and Psychotherapy, Medical Faculty, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. [Reif,A] Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt am Main, Frankfurt am Main, Germany. [Hoffmann,P, Cichon,S] Institute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany. [Pirooznia,M, Goes,FS] Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA, The study was supported by the German Federal Ministry of Education and Research (BMBF) through the Integrated Network IntegraMent (Integrated Understanding of Causes and Mechanisms in Mental Disorders), under the auspices of the e:Med Programme (grant 01ZX1314A/01ZX1614A to M.M.N. Forstner et al. Translational Psychiatry (2020) 10:57 Page 8 of 10 and S.C., grant 01ZX1314G/01ZX1614G to M.R.) and through ERA-NET NEURON, 'SynSchiz—Linking synaptic dysfunction to disease mechanisms in schizophrenia—a multilevel investigation' (01EW1810 to MR). The study was also supported by the German Research Foundation (DFG, grant FOR2107, RI908/11-1 and RI908/11–2 to M.R., and NO246/10-1 and NO 246/10-2 to M.M.N.), and the Swiss National Science Foundation (SNSF, grant 156791 to S.C.). M.M.N. is a member of the DFG-funded Excellence-Cluster ImmunoSensation.

Jerónimo Martínez-García, Emilio M. Serrano-López, Jorge A. Martínez-Escribano, María D. Martínez-Hernández, María V. Martínez-Sánchez, Alfredo Minguela, Senena Corbalán-García, Francisco García-Cózar, Lourdes Gimeno, María A. Cánovas-Zapata, María F Soto-Ramírez, María R. Álvarez-López, O. S. Acuña, Pedro López-Cubillana, José A. Campillo, Biomedicina, Biotecnología y Salud Pública, [Gimeno,L, Campillo,JA, Cánovas-Zapata,MA, Martínez-Sánchez,MV, Martínez-Hernández,MD, Soto-Ramírez,MF, Álvarez-López,MR, Minguela,A] Immunology Service, Hospital Clínico Universitario Virgen de la Arrixaca and Instituto Murciano de Investigación Biomédica (IMIB-Arrixaca), Murcia, Spain. [Gimeno,L] Human Anatomy Department, University of Murcia (UM), Murcia, Spain. [Serrano-López,EM, Corbalan-García,S] Department of Biochemistry and Molecular Biology, Veterinary School, International Excellence Campus 'Campus Mare Nostrum', Universidad Murcia, Murcia, Spain. [Serrano-López,EM, Corbalan-García,S] Biomembranes and Cell Signaling, Instituto Murciano de Investigación Biomédica, Murcia, Spain. [Acuña,OS] Faculty of Veterinary and Zootechnics, Autonomous University of Sinaloa (UAS), Culiacan, Mexico. [Acuña,OS] Department of Research, Animal Reproduction Biotechnology (ARBiotech), Culiacan, Mexico. [García-Cózar,F] Department of Biomedicine, Biotechnology and Public Health (Immunology), University of Cadiz and Institute of Biomedical Research Cádiz (INIBICA), Cadiz, Spain. [López-Cubillana,P] Urology Service, Hospital Clínico Universitario Virgen de la Arrixaca and Instituto Murciano de Investigación Biomédica (IMIB-Arrixaca), Murcia, Spain. [Martínez-Escribano,J] Dermatology Service, Hospital Clínico Universitario Virgen de la Arrixaca and Instituto Murciano de Investigación Biomédica (IMIB-Arrixaca), Murcia, Spain. [Martínez-García,J] Oncology Service, Hospital Clínico Universitario Virgen de la Arrixaca and Instituto Murciano de Investigación Biomédica (IMIB-Arrixaca), Murcia, Spain. [Álvarez-López,MR] Faculty of Health Sciences, Universidad Católica San Antonio de Murcia, UCAM, Murcia, Spain., and This research was funded by the Spanish Ministry of Economy—Institute of Health Carlos III (PI1302297), Fundación Mutua Madrileña (AP74392010), and Fundación Séneca de la Agencia de Ciencia y Tecnología, Región de Murcia, (20812-PI-18). M.V. Martínez-Sánchez was funded by the Asociación Pablo Ugarte (APU).

Barbara Nawrot, Renata Kaczmarek, Andrew S. Marriott, Armel Houel, Sophia Kossida, A. L. Valadao, Nadine Laguette, K. Polak, Christelle Langevin, Dimitrios Vlachakis, Nigel J. Jones, Baptiste Auzemery, Isabelle K. Vila, Pierre Boudinot, Clara Taffoni, Thaneas Prabakaran, Stéphanie Déjardin, Jessica Guerra, Søren R. Paludan, Institut de génétique humaine (IGH), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Laboratory of Genetics, Agricultural University of Athens, Laboratory of Genetics, Department of Biomedicine, Aarhus University [Aarhus], Edge Hill University, Department of Bioorganic Chemistry Centre of Molecular and Macromolecular Studies Polish Academy of Sciences, Polish Academy of Sciences (PAN), Virologie et Immunologie Moléculaires (VIM (UR 0892)), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Department of Biochemistry, University of Liverpool, ANRS French National Research Agency (ANR) 109560, Fondation ARC pour la Recherche sur le Cancer PJA20141201605, Merck Sharp and Dohme Avenir (M.S.D.-GnoSTic), M.S.D., Prix Roger PROPICE pour la recherche sur le cancer du pancreas of the Fondation pour la Recherche Medicale (FRM), SIRIC Montpellier Cancer Grant INCa_Inserm_DGOS_12553, Research Development Fund grant from North West Cancer Research (UK), Novo Nordisk Foundation NNF18OC0030274, Lundbeckfonden R198-2015-171 R268-2016-3927, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, CR863 CR968, European Project: 637763,H2020,ERC-2014-STG,CrIC(2015), European Project: 786602,ENVISION, Genetics Laboratory [Agricultural University of Athens], and Agricultural University of Athens

Martin, Ivan, Department of Biomedicine [Basel], University Hospital Basel [Basel], Laboratoire d'Informatique et Systèmes (LIS), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Departamento de Fisica Teorica and IFIC (CSIC- UVEG), Universitat de València (UV), Aix-Marseille Université et LIS- CANA, Armando Pérez, Giuseppe Di Molfetta, and Pablo Arrighi

Martin, Ivan, Department of Biomedicine [Basel], University Hospital Basel [Basel], Laboratoire d'Informatique et Systèmes (LIS), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), Departamento de Fisica Teorica and IFIC (CSIC- UVEG), Universitat de València (UV), Aix-Marseille Université et LIS- CANA, Armando Pérez, Giuseppe Di Molfetta, and Pablo Arrighi

Eudald Casals, Gregori Casals, Silvia Carvajal, Pedro Melgar-Lesmes, Guillermo Fernández-Varo, Meritxell Perramón, Pedro R. Cutillas, Pedro Casado, Denise Oró, Víctor F. Puntes, Manuel Morales-Ruiz, Wladimiro Jiménez, Jordi Ribera, Institut Català de la Salut, [Carvajal S, Perramón M, Casals G, Oró D, Ribera J] Biochemistry and Molecular Genetics Service, Hospital Clínic Universitari, IDIBAPS, CIBERehd, 08036 Barcelona, Spain. [Morales-Ruiz M] Biochemistry and Molecular Genetics Service, Hospital Clínic Universitari, IDIBAPS, CIBERehd, 08036 Barcelona, Spain. Department of Biomedicine, University of Barcelona, 08036 Barcelona, Spain. [Puntes V] Institut Català de Recerca i Estudis Avançats, (ICREA), 08010 Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Institut Català de Nanociència i Nanotecnologia (ICN2), 08193 Bellaterra, Spain, Vall d'Hebron Barcelona Hospital Campus, Ministerio de Economía y Competitividad (España), Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Generalitat de Catalunya, European Commission, Fundació La Marató de TV3, Wuyi University, Natural Science Foundation of Guangdong Province, Instituto de Salud Carlos III, Perramón, Meritxell, Casals, Gregori, Ribera, Jordi, Casals, Eudald, Jiménez, Wladimiro, Perramón, Meritxell [0000-0002-1944-8337], Casals, Gregori [0000-0002-3271-1371], Ribera, Jordi [0000-0002-0288-4220], Casals, Eudald [0000-0002-2900-7295], and Jiménez, Wladimiro [0000-0002-9376-0214]

Fernandez-Rebollo, Eduardo, Mentrup, Birgit, Ebert, Regina, Franzen, Julia, Abagnale, Giulio, Sieben, Torsten, Ostrowska, Alina, Hoffmann, Per, Roux, Pierre-François, Rath, Björn, Goodhardt, Michele, Lemaitre, Jean-Marc, Bischof, Oliver, Jakob, Franz, Wagner, Wolfgang, Helmholtz-Institute for Biomedical Engineering [RWTH Aachen University], Julius-Maximilians-Universität Würzburg [Wurtzbourg, Allemagne] (JMU), Helmholtz-Institute for Biomedical Engineering (HIA), Rheinisch-Westfälische Technische Hochschule Aachen (RWTH), University of Basel (Unibas), Organisation Nucléaire et Oncogenèse / Nuclear Organization and Oncogenesis, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Différenciation et progression tumorale des lymphocytes, École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut Universitaire d'Hématologie (IUH), Université Paris Diderot - Paris 7 (UPD7)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Philips, Alexandre, Julius-Maximilians-Universität Würzburg (JMU), Rheinisch-Westfälische Technische Hochschule Aachen University (RWTH), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), École Pratique des Hautes Études (EPHE), Institute for Biomedical Technology - Cell Biology [Aachen, Germany], RWTH Aachen University Medical School [Aachen, Germany], Department of Genomics [Bonn, Germany] (Institute of Human Genetics), University of Bonn-Institute of Human Genetics [Bonn, Germany], Human Genomics Research Group [Basel, Switzerland] ( Department of Biomedicine), Organisation Nucléaire et Oncogenèse, École pratique des hautes études (EPHE)-Institut Universitaire d'Hématologie (IUH), and This work was supported by the German Ministry of Education and Research (OBELICS, 01KU1402A, 01KU1402B) and by the Fondation ARC pour la Recherche sur le Cancer.

Ehrmann, Ingrid, Gazzara, Matthew R., Pagliarini, Vittoria, Dalgliesh, Caroline, Kheirollahi-Chadegani, Mahsa, Yaobo Xu, Cesari, Eleonora, Danilenko, Marina, Maclennan, Marie, Lowdon, Kate, Vogel, Tanja, Keskivali-Bond, Piia, Wells, Sara, Cater, Heather, Fort, Philippe, Santibanez-Koref, Mauro, Middei, Silvia, Sette, Claudio, Clowry, Gavin J., Barash, Yoseph, Cunningham, Mark O., Elliott, David J., Institute of Human Genetics (NEWCASTLE UNIVERSITY), Newcastel University, Department of Biomedicine and Prevention, Università degli Studi di Roma Tor Vergata [Roma], Institute of Anatomy and Cell Biology, Albert-Ludwigs-Universität Freiburg, Mary Lyon Centre, MRC Harwell Institute, Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Medical Research Counc, Centre de recherche en Biologie Cellulaire (CRBM), Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1), Dulbecco Telethon Institute/Department of Biology, University of Pennsylvania [Philadelphia], United States Nuclear Regulatory Commission (U.S.NRC), Institute of Genetic Medicine [Newcastle, U.K.], and Newcastle University [Newcastle]

Hamdane, Nourdine, Jühling, Frank, Crouchet, Emilie, El Saghire, Houssein, Thumann, Christine, Oudot, Marine A., Bandiera, Simonetta, Saviano, Antonio, Ponsolles, Clara, Roca Suarez, Armando Andres, Li, Shen, Fujiwara, Naoto, Ono, Atsushi, Davidson, Irwin, Bardeesy, Nabeel, Schmidl, Christian, Bock, Christoph, Schuster, Catherine, Lupberger, Joachim, Habersetzer, François, Doffoël, Michel, Piardi, Tullio, Sommacale, Daniele, Imamura, Michio, Uchida, Takuro, Ohdan, Hideki, Aikata, Hiroshi, Chayama, Kazuaki, Boldanova, Tujana, Pessaux, Patrick, Fuchs, Bryan C., Hoshida, Yujin, Zeisel, Mirjam B., Duong, François H.T., Baumert, Thomas F., Institut de Recherche sur les Maladies Virales et Hépatiques (IVH), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Pôle hépato-digestif [Strasbourg], Nouvel Hôpital Civil, Hospices Civils de Strasbourg-Institut Hospitalo-Universitaire de strasbourg, Division of Surgical Oncology [Boston, MA, USA], Harvard Medical School [Boston] (HMS)-Massachusetts General Hospital Cancer Center [Boston, MA, USA], Harold C. Simmons Comprehensive Cancer Center [Dallas, TX, États-Unis], University of Texas Southwestern Medical Center [Dallas], Department of Gastroenterology and Metabolism [Hiroshima, Japan] (Applied Life Sciences), Hiroshima University-Institute of Biomedical & Health Sciences [Hiroshima, Japan], Department of Gastroenterological and Transplant Surgery [Hiroshima, Japan], Hiroshima University-Graduate School of Biomedical and Health Sciences [Hiroshima, Japan], Hiroshima University, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Center for Cancer Research [Boston, MA, USA], Massachusetts General Hospital [Boston], Department of Medicine [Boston, MA, USA], Harvard Medical School [Boston] (HMS), CeMM Research Center for Molecular Medicine [Vienna, Austria], Austrian Academy of Sciences (OeAW), Regensburg Centre for Interventional Immunology [Regensburg, Germany] (RCI), University Medical Center of Regensburg [Regensburg, Germany], Department of Laboratory Medicine [Vienna, Austria], Medizinische Universität Wien = Medical University of Vienna, Max Planck Institute for Informatics [Saarbrücken], Unité de chirurgie générale, digestive et endocrinienne [HU Robert Debré, Reims], Université de Reims Champagne-Ardenne (URCA)-Centre Hospitalier Universitaire de Reims (CHU Reims)-Hôpital universitaire Robert Debré [Reims], Department of Biomedicine [Basel], University Hospital Basel [Basel], Division of Gastroenterology and Hepatology [Basel], Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), This work was supported by the ARC (Paris) and the Institut Hospitalo- Universitaire (Strasbourg, TheraHCC IHUARC IHU201301187 to Thomas F. Baumert), the Foundation of the University of Strasbourg and Roche Institute (HEPKIN to Thomas F. Baumert and Yujin Hoshida), the Agence Nationale de Recherches sur le Sida et les Hépatites Virales (2017/1633 to Thomas F. Baumert), the U.S. Department of Defense (W81XWH-16-1-0363 to Yujin Hoshida and Thomas F. Baumert), the Cancéropôle du Grand-Est (AAP Emergence 2017 to Joachim Lupberger), the National Institutes of Health (DK099558 to Yujin Hoshida), and the Research Program on Hepatitis from the Japan Agency for Medical Research and Development, AMED (17fk0210104h0001 to Kazuaki Chayama). This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement 667273 (HEPCAR to Thomas F. Baumert and Joachim Lupberger). This project has received funding from the European Research Council under the European Union’s Horizon 2020 Research and Innovation Program under grant 671231 (HEPCIR to Thomas F. Baumert and Yujin Hoshida). This work has been published under the framework of the LABEX ANR-10-LABX-0028_HEPSYS, and PLAN CANCER 2014–2019 and benefits from a funding from the state managed by the French National Research Agency as part of the Investments for the Future Program, the French National Cancer Institute, and INSERM., ANR-10-IDEX-0002,UNISTRA,Par-delà les frontières, l'Université de Strasbourg(2010), European Project: 667273,H2020,H2020-PHC-2015-two-stage,HEP-CAR(2016), European Project: 671231,H2020,ERC-2014-ADG,HEPCIR(2016), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), daulny, anne, Initiative d'excellence - Par-delà les frontières, l'Université de Strasbourg - - UNISTRA2010 - ANR-10-IDEX-0002 - IDEX - VALID, Mechanisms underlying hepatocellular carcinoma pathogenesis and impact of co-morbidities. - HEP-CAR - - H20202016-01-01 - 2019-12-31 - 667273 - VALID, and Cell circuits as targets and biomarkers for liver disease and cancer prevention - HEPCIR - - H20202016-01-01 - 2020-12-31 - 671231 - VALID

Eoin P. Flanagan, Benjamin Greenberg, Olga Ciccarelli, Olaf Stüve, Jean-Philippe Ranjeva, Maria Pia Sormani, Regina Schlaerger, Myla D. Goldman, Jeffrey A. Cohen, Emmanuelle Waubant, Franz Fazekas, Ellen M. Mowry, Daniel S. Reich, Frederik Barkhof, Hans Lassmann, Anthony Traboulsee, Sandra Vukusic, Mar Tintoré, Bernard M. J. Uitdehaag, Anke Henning, Daniel Pelletier, Alan J. Thompson, Junqian Xu, Jorge Correale, Burkhard Becher, Stephen Reingold, Nicola De Stefano, Bruce F. Bebo, Izlem Izbudak, Claudia Chien, Stephen C. Reingold, Steven Galetta, Claudia Gandini Wheeler-Kingshott, Sebastien Ourselin, Alex Rovira, Mark S. Freedman, Brenda Banwell, Aaron E. Miller, Xavier Montalban, Cornelia Laule, Claudia F. Lucchinetti, Giancarlo Comi, Peter A. Calabresi, Hans-Peter Hartung, Maria Trojano, Ludwig Kappos, Bernhard Hemmer, Bruce D. Trapp, Brian G. Weinshenker, Kazuo Fujihara, Tanuja Chitnis, Jérôme De Seze, Francois Bethoux, Per Soelberg Sørensen, Fred D. Lublin, Alexander U. Brandt, Carsten Lukas, Wallace J Brownlee, Maria Pia Amato, Jeremy Chatway, David Miller, Friedemann Paul, Maria A. Rocca, Ruth Ann Marrie, Michael J. Levy, University of Pennsylvania, VU University Medical Center [Amsterdam], University College of London [London] (UCL), Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Departamento de Neurologia, Instituto de Investigaciones Neurológicas 'Dr. Raul Carrea', Instituto de Investigaciones Neurológicas 'Dr. Raul Carrea', Service de Neurologie [Strasbourg], CHU Strasbourg-Hopital Civil, Dept. of Neurological and Behavioural Sciences, Siena, Department of Neurology [Austria], Medical University Graz, Ottawa Hospital Research Institute [Ottawa] (OHRI), Tohoku University Graduate School of Medicine, Munich Cluster of Systems Neurology (SyNery), Clinical Neuroimmunology, Department of Biomedicine, University of Basel, Basel, Matière et Systèmes Complexes (MSC), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), St. Josef Hospital, Ruhr-University Bochum, Vall Hebron Research Institute (VHIR), Translational imaging group [London] (TIG), Centre for Medical Image Computing (CMIC), University College of London [London] (UCL)-University College of London [London] (UCL)-Department of Medical Physics and Biomedical Engineering (UCL), Max Delbrueck Centre for Molecular Medicine, Departments of Neurology and Immunobiology [Yale], Yale School of Medicine [New Haven, Connecticut] (YSM), Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - APHM] (CEMEREM), Hôpital de la Timone [CHU - APHM] (TIMONE)-Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU), Centre National de la Recherche Scientifique (CNRS), National Institutes of Health [Bethesda] (NIH), Vall d'Hebron University Hospital [Barcelona], Dept. of Neurology, University Hospital Rigshospitalet, Centre d'Esclerosi Múltiple de Catalunya (CemCat), Division of Geriatric Medicine, University of British Columbia (UBC), Service de Neurologie [Lyon], CHU Lyon, Department of Neurology, University of California [San Francisco] (UC San Francisco), University of California (UC)-University of California (UC), NMR Research Unit [London], Institute of Neurology [London], University College of London [London] (UCL)-University College of London [London] (UCL), Icahn School of Medicine at Mount Sinai [New York] (MSSM), University of Pennsylvania [Philadelphia], Matière et Systèmes Complexes (MSC (UMR_7057)), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Yale University School of Medicine, Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - AP-HM] (CEMEREM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS)- Hôpital de la Timone [CHU - APHM] (TIMONE), University of California [San Francisco] (UCSF), and University of California-University of California

Gregori Casals, Jordi Ribera, Manuel Morales-Ruiz, Guillermo Fernández-Varo, Denise Oró, Eudald Casals, Wladimiro Jiménez, Óscar Pastor, Marina Parra, Víctor F. Puntes, Bernardino González de la Presa, Meritxell Perramón, Silvia Carvajal, Ministerio de Economía y Competitividad (España), European Commission, Instituto de Salud Carlos III, Generalitat de Catalunya, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Casals, Eudald, [Carvajal S, Perramón M, Oró D] Biochemistry and Molecular Genetics Service, Hospital Clínic Universitari, IDIBAPS, Barcelona, Spain. Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas (CIBEREHD), Madrid, Spain. [Casals E] School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, China. [Fernández-Varo G] Biochemistry and Molecular Genetics Service, Hospital Clínic Universitari, IDIBAPS, Barcelona, Spain. Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas (CIBEREHD), Madrid, Spain. Department of Biomedicine, University of Barcelona, Barcelona, Spain. [Casals G] Biochemistry and Molecular Genetics Service, Hospital Clínic Universitari, IDIBAPS, Barcelona, Spain. Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas (CIBEREHD), Madrid, Spain. Working group for the biochemical assessment of hepatic disease-SEQCML, Barcelona, Spain. [Puntes V] Institut Català de Recerca i Estudis Avançats, (ICREA), Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Institut Català de Nanociència i Nanotecnologia (ICN2), Universitat Autònoma de Barcelona, Bellaterra, Spain, Vall d'Hebron Barcelona Hospital Campus, and Casals, Eudald [0000-0002-2900-7295]

Wang De Yun, Wendy W. L. Lee, Gennaro DeLibero, Ricardo C.H. del Rosario, Dilip Kumar, Kia Joo Puan, Shyam Prabhakar, Nurhashikin Yusof, Jeremie Poschmann, Bernett Lee, Amit Singhal, Olaf Rötzschke, Pavanish Kumar, Michael Poidinger, Anand Kumar Andiappan, Boris San Luis, Le Bihan, Sylvie, Singapore Immunology Network (SIgN), Biomedical Sciences Institute (BMSI), Genome Institute of Singapore (GIS), Stanley Center for Psychiatric Research [Cambridge, MA, USA], Broad Institute of MIT and Harvard (BROAD INSTITUTE), Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston]-Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston], Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Department of Biomedicine [Basel], University Hospital Basel [Basel], Department of Otolaryngology [Singapore, Singapore], National University of Singapore (NUS), Singapore Ministry of Education Academic Research Fund (R-154-000-404-112, R-154-000-553-112, R-154-000-565-112, R-154-000-630-112), National Medical Research Council (NMRC, and Singapore, NMRC/1150/2008), and Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR) Singapore (SIgN-06-006, SIgN-08-020, and SIgN-10-029). Dr. Bernett Lee is part of SIgN Immunomonitoring platform supported by a BMRC IAF 311006 grant and BMRC transition funds #H16/99/b0/011.

Marcus Krüger, Jean-Paul Chapel, Nithya Vadakedath, Binod Prasad, Jacob Cohen, Philippe Darriet, Sebastian M. Strauch, Rocco L. Mancinelli, Daniela Grimm, Michael Lebert, Peter Richter, Department of Biology, Friedrich-Alexander-University Erlangen-Nuremberg, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Department of Biology, Division of Biochemistry, Friedrich-Alexander, Council of Scientific and Industrial Research [India] (CSIR), Bay Area Environmental Research Institute (BAER), Clinic for Plastic, Aesthetic and Hand Surgery, University of the Region of Joinville, Department of Biomedicine, Aarhus University, Unité de Recherche Oenologie [Villenave d'Ornon], Université de Bordeaux (UB)-Institut des Sciences de la Vigne et du Vin (ISVV)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre de Recherche Paul Pascal (CRPP), Université de Bordeaux (UB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and National Aeronautics and Space Administration, Ames research Center

Athanasia Bletsa, Anca Virtej, Panagiota Papadakou, Hajime Sasaki, Ellen Berggreen, Åse Rye Eriksen and Pål William Wallace, Department of Biomedicine, University of Bergen, Bronislaw Pytowski and Eli Lilly and Company, NY, US, and University of Bergen and Helse Vest project number 911684.

Usue Etxaniz, Sole Gatto, Vittoria Pagliarini, Ricardo Rojas-García, Maria Vittoria Alfonsi, David Sala, Sara Marinelli, Francesca Lugarini, Daisy Proietti, Alessandra Sacco, Lorenzo Giordani, Luca Madaro, Claudio Sette, Pier Lorenzo Puri, Chiara Nicoletti, Magda Passafaro, Marco De Bardi, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement (LGL-TPE), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut national des sciences de l'Univers (INSU - CNRS)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), Fondazione Santa Lucia [IRCCS], Clinical and Behavioral Neurology [IRCCS Santa Lucia], CIBER de Enfermedades Raras (CIBERER), Centre de recherche en Myologie – U974 SU-INSERM, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Department of Biomedicine and Prevention, Università degli Studi di Roma Tor Vergata [Roma], and Sanford Burnham Prebys Medical Discovery Institute

Caroline Lacoux, Jessica Mingardi, Daniela Bonini, Luca La Via, Claudia Bagni, Maria Zingariello, Alice Filippini, Laura Pacini, Daniela Bosisio, Laura Sancillo, Francesca Zalfa, Alessandro Barbon, Valentina Salvi, Filippini, A, Bonini, D, Lacoux, C, Pacini, L, Zingariello, M, Sancillo, L, Bosisio, D, Salvi, V, Mingardi, J, LA VIA, L, Zalfa, F, Bagni, C, Barbon, A, University of Brescia, Department of Biomedicine and Prevention, Università degli Studi di Roma Tor Vergata [Roma], Università Campus Bio-Medico di Roma, Partenaires INRAE, Università degli studi 'G. d'Annunzio' Chieti-Pescara [Chieti-Pescara] (Ud'A), Flanders Institute for Biotechnology, Lausanne University Hospital, MIUR (PRIN) [2012A9T2S9_004], Fondazione Cariplo, Associazione Italiana Sindrome X Fragile, Telethon [GGP15257], Lejeune Foundation, and La Via, L