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16 results on '"Deotto, Luciano"'

1. Clinical spectrum and IgG subclass analysis of anti-myelin oligodendrocyte glycoprotein antibody-associated syndromes: a multicenter study

Author

Mariotto, Sara, Ferrari, Sergio, Monaco, Salvatore, Benedetti, Maria Donata, Schanda, Kathrin, Alberti, Daniela, Farinazzo, Alessia, Capra, Ruggero, Mancinelli, Chiara, De Rossi, Nicola, Bombardi, Roberto, Zuliani, Luigi, Zoccarato, Marco, Tanel, Raffaella, Bonora, Adriana, Turatti, Marco, Calabrese, Massimiliano, Polo, Alberto, Pavone, Antonino, Grazian, Luisa, Sechi, GianPietro, Sechi, Elia, Urso, Daniele, Delogu, Rachele, Janes, Francesco, Deotto, Luciano, Cadaldini, Morena, Bianchi, Maria Rachele, Cantalupo, Gaetano, Reindl, Markus, and Gajofatto, Alberto

Published
2017
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2. Off-label thrombolysis versus full adherence to the current European Alteplase license: impact on early clinical outcomes after acute ischemic stroke

Author

Cappellari, Manuel, Moretto, Giuseppe, Micheletti, Nicola, Donato, Francesco, Tomelleri, Giampaolo, Gulli, Giosuè, Carletti, Monica, Squintani, Giovanna Maddalena, Zanoni, Tiziano, Ottaviani, Sarah, Romito, Silvia, Tommasi, Giorgio, Musso, Anna Maria, Deotto, Luciano, Gambina, Giuseppe, Zimatore, Domenico Sergio, and Bovi, Paolo

Published
2014
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3. Early diagnosis of progressive multifocal leucoencephalopathy: Longitudinal lesion evolution

Author

Scarpazza, Cristina, Signori, Alessio, Prosperini, Luca, Sormani, Maria Pia, Cosottini, Mirco, Capra, Ruggero, Gerevini, Simonetta, Altieri, Marta, Amato, Maria Pia, Artusi, Carlo Alberto, Bandini, Fabio, Barcella, Valeria, Bertolotto, Antonio, Morra, Vincenzo Brescia, Capobianco, Marco, Cavaletti, Guido, Cavalla, Paola, Centonze, Diego, Chiusole, Maurizia, Clerico, Marinella, Cordioli, Cinzia, D'Aleo, Giangaetano, De Luca, Giovanna, De Riz, Milena, De Rossi, Nicola, Deotto, Luciano, Durelli, Luca, Falcini, Mario, Ferrante, Claudio, Ferrari, Ernesta, Fusco, Maria Luisa, Gasperini, Claudio, Ghezzi, Angelo, Grimaldi, Luigi, Guidotti, Mario, Laroni, Alice, Lugaresi, Alessandra, Moiola, Lucia, Naldi, Paola, Pane, Chiara, Palmeri, Barbara, Perrone, Patrizia, Pizzorno, Matteo, Pozzilli, Carlo, Rezzonico, Monica, Rottoli, Maria Rosa, Rovaris, Marco, Salemi, Giuseppe, Salvetti, Marco, Santuccio, Giuseppe, Scarpini, Elio, Sessa, Edoardo, Solaro, Claudio, Stenta, Gianola, Tabiadon, Giulietta, Tortorella, Carla, Trojano, Maria, Valentino, Paola, Rottoli, Maira Rosa, Scarpazza, C, Signori, A, Prosperini, L, Sormani, M, Cosottini, M, Capra, R, Gerevini, S, Altieri, M, Amato, M, Artusi, C, Bandini, F, Barcella, V, Bertolotto, A, Morra, V, Capobianco, M, Cavaletti, G, Cavalla, P, Centonze, D, Chiusole, M, Clerico, M, Cordioli, C, D'Aleo, G, De Luca, G, De Riz, M, De Rossi, N, Deotto, L, Durelli, L, Falcini, M, Ferrante, C, Ferrari, E, Fusco, M, Gasperini, C, Ghezzi, A, Grimaldi, L, Guidotti, M, Laroni, A, Lugaresi, A, Moiola, L, Naldi, P, Pane, C, Palmeri, B, Perrone, P, Pizzorno, M, Pozzilli, C, Rezzonico, M, Rottoli, M, Rovaris, M, Salemi, G, Salvetti, M, Santuccio, G, Scarpini, E, Sessa, E, Solaro, C, Stenta, G, Tabiadon, G, Tortorella, C, Trojano, M, and Valentino, P

Subjects
natalizumab treatment, Adult, Male, medicine.medical_specialty, Multiple Sclerosis, Surgery, Neurology (clinical), Psychiatry and Mental Health, natalizumab, progressive multifocal leucoencephalopathy, Progressive Multifocal, Lesion, Leukoencephalopathy, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Psychiatry and Mental Health, progressive multifocal leucoencephalopathy, medicine, Humans, Immunologic Factors, Young adult, Progressive multifocal leucoencephalopathy, Retrospective Studies, medicine.diagnostic_test, business.industry, Multiple sclerosis, Natalizumab, Leukoencephalopathy, Progressive Multifocal, Magnetic resonance imaging, Retrospective cohort study, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Early Diagnosis, Female, Italy, Cohort, Settore MED/26 - Neurologia, Radiology, medicine.symptom, business, 030217 neurology & neurosurgery
Abstract

ObjectiveEarly diagnosis of natalizumab-related progressive multifocal leucoencephalopathy (NTZ-PML) in multiple sclerosis has been deemed a major priority by the regulatory agencies but has yet to become a reality. The current paper aims to: (1) investigate whether patients with NTZ-PML pass through a prolonged presymptomatic phase with MRI abnormalities, (2) estimate the longitudinal PML lesion volume increase during the presymptomatic phase and (3) estimate the presymptomatic phase length and its impact on therapy duration as a risk stratification parameter.MethodsAll Italian patients who developed NTZ-PML between 2009 and 2018 were included. The data of patients with available prediagnostic MRI were analysed (n=41). Detailed clinical and neuroradiological information was available for each participant.Results(1) PML lesions were detectable in the presymptomatic phase in 32/41 (78%) patients; (ii) the lesion volume increased by 62.8 % for each month spent in the prediagnostic phase; (3) the prediagnostic phase length was 150.8±74.9 days; (4) PML MRI features were detectable before the 24th month of therapy in 31.7 % of patients in our cohort.ConclusionsConsidering the latency of PML clinical manifestation, the presymptomatic phase length supports the usefulness of MRI surveillance every 3–4 months. Early diagnosis could prompt a better outcome for patients due to the relationship between lesion volume and JC virus infection. The insight from this study might also have an impact on risk stratification algorithms, as therapy duration as a parameter of stratification appears to need reassessment.

Published
2019

4. To do or not to do? plasma exchange and timing of steroid administration in progressive multifocal leukoencephalopathy

Author

Scarpazza, Cristina, Prosperini, Luca, De Rossi, Nicola, Moiola, Lucia, Sormani, Maria Pia, Gerevini, Simonetta, Capra, Ruggero, Altieri, Marta, Amato, Maria Pia, Artusi, Carlo Alberto, Bandini, Fabio, Barcella, Valeria, Bertolotto, Antonio, Morra, Vincenzo Brescia, Capobianco, Marco, Cavaletti, Guido, Cavalla, Paola, Centonze, Diego, Clerico, Marinella, Cocco, Eleonora, Cordioli, Cinzia, Cosottini, Mirco, D'Aleo, Giangaetano, de Luca, Giovanna, de Riz, Marilena, Deotto, Luciano, Durelli, Luca, Falcini, Mario, Ferrari, Ernesta, Ferrante, Claudio, Fusco, Maria Luisa, Gasperini, Claudio, Ghezzi, Angelo, Grimaldi, Luigi, Guidotti, Mario, Laroni, Alice, Lugaresi, Alessandra, Naldi, Paola, Pane, Chiara, Perrone, Patrizia, Pizzorno, Matteo, Pozzilli, Carlo, Rezzonico, Monica, Rovaris, Marco, Salemi, Giuseppe, Salvetti, Marco, Santuccio, Giuseppe, Scarpini, Elio, Sessa, Edoardo, Solaro, Claudio, Tabiadon, Giulia, Tortorella, Carla, Trojano, Maria, Valentino, Paola, Scarpazza, Cristina, Prosperini, Luca, De Rossi, Nicola, Moiola, Lucia, Sormani, Maria Pia, Gerevini, Simonetta, and Capra, Ruggero, Amato MP, Artusi CA, Bandini F, Barcella V, Bertolotto A, Bresciamorra V, Capobianco M, Cavaletti G, Cavalla P, Centonze D, Clerico M, Cordioli C, D’Aleo G, de Riz M, Deotto L, Durelli L, Falcini M, Ferrari E, Fusco ML, Gasperini C, Ghezzi A, Grimaldi L, Guidotti M, Laroni A, Lugaresi A, Naldi P, Pane C, Perrone P, Pizzorno M, Pozzilli C, Prosperini L, Rezzonico M, Rovaris M, Salemi G, Salvetti M, Santuccio G, Scarpini E, Sessa E, Solaro C, Tabiadon G, Tortorella C, Trojano M, Valentino P

Subjects
Adult, Male, Databases, Factual, Disability Evaluation, Female, Humans, Immune Reconstitution Inflammatory Syndrome, Leukoencephalopathy, Progressive Multifocal, Plasma Exchange, Retrospective Studies, Steroids, Young Adult, Neurology, Neurology (clinical), Progressive Multifocal, Databases, Leukoencephalopathy, Retrospective Studie, Settore MED/26 - Neurologia, Steroid, Factual, Human
Abstract

OBJECTIVE: To retrospectively analyze the effect of plasma exchange (PLEX; yes = PLEX+ , no = PLEX- ) and steroids administration timing (prophylactically [proST] or therapeutically [therST]) on the longitudinal clinical course of patients with natalizumab-related progressive multifocal leukoencephalopathy (PML) and full-blown immune reconstitution inflammatory syndrome (PML-IRIS). METHODS: Clinical and radiological data of 42 Italian patients with PML were analyzed. Patient's data are available until 12 months after PML diagnosis. PLEX and steroids treatment as time-dependent covariates were entered in: (1) a Cox model to investigate their impact on full-blown PML-IRIS latency; (2) an analysis of variance ANOVA to investigate their impact on IRIS duration; and (3) a linear mixed model to assess their impact on the longitudinal clinical course (measured by means of Expanded Disability Status Scale [EDSS]). RESULTS: Treatment with PLEX was not associated to PML-IRIS latency (hazard ratio [HR] = 1.05; p = 0.92), but once IRIS emerged, its duration was significantly longer in patients who underwent PLEX (101 vs 54 days in PLEX+ and PLEX- patients; p = 0.028). Receiving proST versus therST was not associated to IRIS latency (HR = 0.67; p = 0.39) or duration (p = 0.95). Patients who underwent proST had a significantly higher EDSS increase during PML (0.09 EDSS points per month; p = 0.04) as compared to those who had therST. INTERPRETATION: This study highlights that: (1) caution on the use of PLEX should be considered as the current data do not support a beneficial effect of PLEX and (2) caution on the early use of steroids is suggested because their prophylactic use to prevent full-blown PML-IRIS seems to negatively impact on the longitudinal disability course.

Published
2017

5. The still under-investigated role of cognitive deficits in PML diagnosis

Author

Scarpazza, Cristina, De Rossi, Nicola, Moiola, Lucia, Gerevini, Simonetta, Cosottini, Mirco, Capra, Ruggero, Mattioli, Flavia, Amato, Maria Pia, Artusi, Carlo Alberto, Bandini, Fabio, Barcella, Valeria, Bertolotto, Antonio, Bresciamorra, Vincenzo, Capobianco, Marco, Cavaletti, Guido, Cavalla, Paola, Centonze, Diego, Clerico, Marinella, Cordioli, Cinzia, D'Aleo, Giangaetano, de Riz, Marilena, Deotto, Luciano, Durelli, Luca, Falcini, Mario, Ferrari, Ernesta, Fusco, Maria Luisa, Gasperini, Claudio, Ghezzi, Angelo, Grimaldi, Luigi, Guidotti, Mario, Laroni, Alice, Lugaresi, Alessandra, Naldi, Paola, Pane, Chiara, Perrone, Patrizia, Pizzorno, Matteo, Pozzilli, Carlo, Prosperini, Luca, Rezzonico, Monica, Rovaris, Marco, Salemi, Giuseppe, Salvetti, Marco, Santuccio, Giuseppe, Scarpini, Elio, Sessa, Edoardo, Solaro, Claudio, Tabiadon, Giulia, Tortorella, Carla, Trojano, Maria, Valentino, Paola, Scarpazza C, De Rossi N, Gerevini S, Cosottini M, Capra R, Mattioli F, Amato MP, Artusi CA, Bandini F, Barcella V, Bertolotto A, Bresciamorra V, Capobianco M, Cavaletti G, Cavalla P, Centonze D, Clerico M, Cordioli C, D’Aleo G, de Riz M, Deotto L, Durelli L, Falcini M, Ferrari E, Fusco ML, Gasperini C, Ghezzi A, Grimaldi L, Guidotti M, Laroni A, Lugaresi A, Naldi P, Pane C, Perrone P, Pizzorno M, Pozzilli C, Prosperini L, Rezzonico M, Rovaris M, Salemi G, Salvetti M, Santuccio G, Scarpini E, Sessa E, Solaro C, Tabiadon G, Tortorella C, Trojano M, Valentino P., Scarpazza, C, De Rossi, N, Moiola, L, Gerevini, S, Cosottini, M, Capra, R, Mattioli, F, Amato, M, Artusi, C, Bandini, F, Barcella, V, Bertolotto, A, Bresciamorra, V, Capobianco, M, Cavaletti, G, Cavalla, P, Centonze, D, Clerico, M, Cordioli, C, D'Aleo, G, de Riz, M, Deotto, L, Durelli, L, Falcini, M, Ferrari, E, Fusco, M, Gasperini, C, Ghezzi, A, Grimaldi, L, Guidotti, M, Laroni, A, Lugaresi, A, Naldi, P, Pane, C, Perrone, P, Pizzorno, M, Pozzilli, C, Prosperini, L, Rezzonico, M, Rovaris, M, Salemi, G, Salvetti, M, Santuccio, G, Scarpini, E, Sessa, E, Solaro, C, Tabiadon, G, Tortorella, C, Trojano, M, and Valentino, P

Subjects
0301 basic medicine, cognition, medicine.medical_specialty, Pediatrics, italian database, natalizumab, neuropsychological impairment, progressive multifocal leukoencephalopathy, neurology (clinical), neurology, immunology, immunology and allergy, Neurology, Settore MED/17 - Malattie Infettive, Asymptomatic, Apraxia, 03 medical and health sciences, 0302 clinical medicine, medicine, Dementia, Psychiatry, Cognitive deficit, Progressive multifocal leukoencephalopathy, Neuropsychology, Cognition, Progressive multifocal leukoencephalopathy Natalizumab Cognition Neuropsychological impairment Italian database, medicine.disease, 030104 developmental biology, Italian database, Natalizumab, Neuropsychological impairment, Cognition, Italian database, Natalizumab, Neuropsychological impairment, Progressive multifocal leukoencephalopathy, Immunology and Allergy, Immunology, Neurology (clinical), Settore MED/26 - Neurologia, medicine.symptom, Psychology, 030217 neurology & neurosurgery
Abstract

Background: Despite cognitive deficits frequently represent the first clinical manifestations of Progressive Multifocal Leukoencephalopathy (PML) in Natalizumab-treated MS patients, the importance of cognitive deficits in PML diagnosis is still under-investigated. The aim of the current study is to investigate the cognitive deficits at PML diagnosis in a group of Italian patients with PML. Methods: Thirty-four PML patients were included in the study. The demographic and clinical data, the lesion load and localization, and the longitudinal clinical course was compared between patients with (n = 13) and without (n = 15) cognitive deficit upon PML suspicion (the remaining six patients were asymptomatic). Clinical presentation of cognitive symptoms was described in detail. Result: After symptoms detection, the time to diagnosis resulted to be shorter for patients presenting with cognitive than for patients with non cognitive onset (p = 0.03). Within patients with cognitive onset, six patients were presenting with language and/or reading difficulties (46.15%); five patients with memory difficulties (38.4%); three patients with apraxia (23.1%); two patients with disorientation (15.3%); two patients with neglect (15.3%); one patients with object agnosia (7.7%), one patient with perseveration (7.7%) and one patient with dementia (7.7%). Frontal lesions were less frequent (p = 0.03), whereas temporal lesions were slightly more frequent (p = 0.06) in patients with cognitive deficits. The longitudinal PML course seemed to be more severe in cognitive than in non cognitive patients (F = 2.73, p = 0.03), but differences disappeared (F = 1.24, p = 0.29) when balancing for the incidence of immune reconstitution syndrome and for other treatments for PML (steroids, plasma exchange (PLEX) and other therapies (Mefloquine, Mirtazapine, Maraviroc). Conclusion: Cognitive deficits at PML onset manifest with symptoms which are absolutely rare in MS. Their appearance in MS patients should strongly suggest PML. Clinicians should be sensitive to the importance of formal neuropsychological evaluation, with particular focus on executive function, which are not easily detected without a formal assessment.

Published
2017

8. Natalizumab-Related Progressive Multifocal Leukoencephalopathy (PML) in Multiple Sclerosis (MS) Italian Patients: Course, Outcome and Follow-Up (P2.061)

Author

De Rossi, Nicola, primary, Cordioli, Cinzia, additional, Amato, Maria Pia, additional, Gerevini, Simonetta, additional, Clerico, Marinella, additional, Deotto, Luciano, additional, De Riz, Milena Alessandra, additional, Scarpazza, Cristina, additional, Fusco, Maria Letizia, additional, Ghezzi, Angelo, additional, Grimaldi, Luigi Maria, additional, Lugaresi, Alessandra, additional, Moiola, Lucia, additional, Perrone, Patrizia Susanna Mar, additional, Prosperini, Luca, additional, Rezzonico, Monica, additional, Rovaris, Marco, additional, Salemi, Giuseppe, additional, Salvetti, Marco, additional, Santuccio, Giuseppe, additional, Tortorella, Carla, additional, and Capra, Ruggero, additional

Published
2016
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9. Natalizumab-related PML in multiple sclerosis patients in Italy. Report of the Italian Group for MS-PML Study (P4.034)

Author

Cordioli, Cinzia, primary, De Rossi, Nicola, additional, Gerevini, Simonetta, additional, Amato, Maria Pia, additional, Bandini, Fabio, additional, Cavalla, Paola, additional, Capobianco, Marco, additional, Deotto, Luciano, additional, De Riz, Milena Alessandra, additional, Ferrari, Ernesta, additional, Fusco, Maria Letizia, additional, Ghezzi, Angelo, additional, Grimaldi, Luigi Maria, additional, Lugaresi, Alessandra, additional, Moiola, Lucia, additional, Perrone, Patrizia Susanna Mar, additional, Prosperini, Luca, additional, Rezzonico, Monica, additional, Rovaris, Marco, additional, Salemi, Giuseppe, additional, Salvetti, Marco, additional, Solaro, Claudio, additional, Tortorella, Carla, additional, and Capra, Ruggero, additional

Published
2015
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12. Off-label thrombolysis versus full adherence to the current European Alteplase license: impact on early clinical outcomes after acute ischemic stroke

Author

Cappellari, Manuel, primary, Moretto, Giuseppe, additional, Micheletti, Nicola, additional, Donato, Francesco, additional, Tomelleri, Giampaolo, additional, Gulli, Giosuè, additional, Carletti, Monica, additional, Squintani, Giovanna Maddalena, additional, Zanoni, Tiziano, additional, Ottaviani, Sarah, additional, Romito, Silvia, additional, Tommasi, Giorgio, additional, Musso, Anna Maria, additional, Deotto, Luciano, additional, Gambina, Giuseppe, additional, Zimatore, Domenico Sergio, additional, and Bovi, Paolo, additional

Published
2013
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13. Myopathy with lipid accumulation and type-II glutaric aciduria

Author

Tomelleri, Giuliano, Burlina, A., Deotto, Luciano, Orrico, D., Tonin, Paola, and Rizzuto, Nicolo'

Subjects
myopathy, type-II glutaric aciduria, lipid accumulation, Fatty Acid Desaturases, Glutarates, Adolescent, Muscular Diseases, Flavin-Adenine Dinucleotide, Humans, Female, Lipid Metabolism, Inborn Errors
Published
1991

15. Natalizumab-Related Progressive Multifocal Leukoencephalopathy (PML) in Multiple Sclerosis (MS) Italian Patients: Course, Outcome and Follow-Up

Author

Rossi, Nicola, Cardinli, Cinzia, Amato, Maria Pia, Gerevini, Simonetta, Marinella CLERICO, Deotto, Luciano, Riz, Milena Alessandra, Scarpazza, Cristina, Fusco, Maria Letizia, Ghezzi, Angelo, Grimaldi, Luigi Maria, Lugaresi, Alessandra, Moiola, Lucia, Perrone, Patrizia Susanna Mar, Prosperini, Luca, Rezzonico, Monica, Rovaris, Marco, Salemi, Giuseppe, Salvetti, Marco, Santuccio, Giuseppe, Tortorella, Carla, and Capra, Ruggero

16. Pain Modulation after Oromucosal Cannabinoid Spray (SATIVEX ® ) in Patients with Multiple Sclerosis: A Study with Quantitative Sensory Testing and Laser-Evoked Potentials.

Author

Turri M, Teatini F, Donato F, Zanette G, Tugnoli V, Deotto L, Bonetti B, and Squintani G

Abstract

Background. Delta-9-tetrahydrocannabinol (THC)/cannabidiol (CBD) (nabiximols or Sativex ® ) is an oromucosal spray formulation containing THC and CBD at an approximately 1:1 fixed ratio. Its administration for the treatment of pain in patients with multiple sclerosis (MS) has been established. MS patients generally complain of different kinds of pain, including spasticity-related and neuropathic pain. In this study, we compared and evaluated pain modulation and thermal/pain threshold of MS patients before and after THC/CBD administration. Methods. 19 MS patients underwent clinical examination, numerical rating scale (NRS), quantitative sensory testing (QST), and laser-evoked potentials (LEPs) before and after 1 month of therapy. Psychophysiological and neurophysiological data were compared to sex- and age-matched controls. Results. Patients reported a significant reduction in pain. We found statistically significant differences in LEP parameters between patients and controls but no significant change in LEP measures after THC/CBD therapy. Cold and heat detection thresholds were altered in patients but did not change after THC/CBD therapy. There was a significant increase in cold pain threshold by hand stimulation and a significant reduction in abnormal cold perception thresholds. Conclusions. Our results indicate that Sativex ® therapy provides pain relief in MS patients and suggest that it might modulate peripheral cold-sensitive TRP channels.

Published
2018
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