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24 results on '"Denzel, Dominik"'

3. Immunological causes of obsessive-compulsive disorder: is it time for the concept of an “autoimmune OCD” subtype?

Author

Endres, Dominique, Pollak, Thomas A., Bechter, Karl, Denzel, Dominik, Pitsch, Karoline, Nickel, Kathrin, Runge, Kimon, Pankratz, Benjamin, Klatzmann, David, Tamouza, Ryad, Mallet, Luc, Leboyer, Marion, Prüss, Harald, Voderholzer, Ulrich, Cunningham, Janet L., Domschke, Katharina, Tebartz van Elst, Ludger, and Schiele, Miriam A.

Published
2022
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4. An observational study on the association of anti-thyroid autoantibodies with clinical, EEG, MRI, FDG-PET, cerebrospinal fluid and anti-neuronal antibody findings in 530 patients with schizophreniform and affective disorders

Author

Endres, Dominique, Runge, Kimon, Meixensberger, Sophie, Feige, Bernd, Denzel, Dominik, Pankratz, Benjamin, Maier, Simon, Nickel, Kathrin, Michel, Maike, Venhoff, Nils, Schiele, Miriam A., Domschke, Katharina, Prüss, Harald, and Tebartz van Elst, Ludger

Published
2021
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10. Neurexan (Nx4) acts on regions in the brain improving emotion regulation

Author

Herrmann, Luisa, Vicheva, Petya, Kasties, Vanessa, Danyeli, Lena V., Szycik, Gregor R., Denzel, Dominik, Fan, Yan, Van der Meer, Johan, Vester, Johannes C., Eskoetter, Herbert, Schultz, Myron, and Walter, Martin

Subjects
Biomedical and clinical sciences, Central nervous system, FOS: Clinical medicine, Neurosciences, Psychiatry (incl. psychotherapy), Clinical and health psychology
Abstract

This is a plain language summary of a published peer-reviewed article. It refers to a clinical trial demonstrating effects of the natural medication Neurexan in reducing hyperactivity in a brain region responsible for emotional processing. This summary was not peer-reviewed but it represents the opinions of the authors. For a full list of declarations, including funding and author disclosure statements, please read the full open-access article online.

Published
2023
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11. Cerebrospinal fluid findings in adult patients with obsessive-compulsive disorder: A retrospective analysis of 54 samples

Author

Pankratz, Benjamin, primary, von Zedtwitz, Katharina, additional, Runge, Kimon, additional, Denzel, Dominik, additional, Nickel, Kathrin, additional, Schlump, Andrea, additional, Pitsch, Karoline, additional, Maier, Simon, additional, Dersch, Rick, additional, Voderholzer, Ulrich, additional, Domschke, Katharina, additional, Tebartz van Elst, Ludger, additional, Schiele, Miriam A., additional, Prüss, Harald, additional, and Endres, Dominique, additional

Published
2022
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12. Cerebrospinal fluid findings in adult patients with obsessive-compulsive disorder: A retrospective analysis of 54 samples.

Author

Pankratz, Benjamin, von Zedtwitz, Katharina, Runge, Kimon, Denzel, Dominik, Nickel, Kathrin, Schlump, Andrea, Pitsch, Karoline, Maier, Simon, Dersch, Rick, Voderholzer, Ulrich, Domschke, Katharina, Tebartz van Elst, Ludger, Schiele, Miriam A., Prüss, Harald, and Endres, Dominique

Subjects
CEREBROSPINAL fluid examination, CILIA & ciliary motion, AUTOANTIBODIES, CEREBROSPINAL fluid, OBSESSIVE-compulsive disorder, GRANULE cells, INTRACRANIAL hypertension, NEUROBEHAVIORAL disorders
Abstract

Obsessive-compulsive disorder (OCD) can rarely be associated with immunological aetiologies, most notably in Paediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infections and possibly in autoimmune encephalitis. As cerebrospinal fluid (CSF) analysis is a sensitive method for assessing neuroinflammation, this retrospective study analysed basic CSF parameters and well-characterised as well as novel neuronal autoantibodies in OCD to screen for signs of autoimmunity. Basic CSF findings of 54 adult OCD patients suspected of an organic aetiology were retrospectively compared to a control group of mentally healthy patients (N = 39) with idiopathic intracranial hypertension. Further subgroup analysis included testing for well-characterised neuronal IgG autoantibodies and tissue-based assays using indirect immunofluorescence to screen for novel brain autoantibodies. Elevated protein in the CSF of OCD patients compared to the control group (p = 0.043) was identified. Inflammatory markers (pleocytosis/oligoclonal bands/increased IgG-index) were detected in 7% of all patients with OCD. Well-characterised neuronal autoantibodies were not found in any OCD patient, whereas 6/18 (33%) CSF samples showed binding on mouse brain sections in tissue-based assays (binding to neuropil in the basal ganglia/brainstem, cilia of granule cells, blood vessels, nuclear/perinuclear structures). While elevated CSF protein is merely a weak indicator of blood CSF barrier dysfunction, the presence of inflammatory CSF changes and novel brain autoantibodies in CSF may indicate OCD subtypes with inflammatory pathomechanism and supports the hypothesis of a rare "autoimmune OCD" subtype. [ABSTRACT FROM AUTHOR]

Published
2023
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14. Anti-MOG autoantibody-associated schizophreniform psychosis

Author

von Zedtwitz, Katharina, primary, Matteit, Isabelle, additional, Michel, Maike, additional, Feige, Bernd, additional, Runge, Kimon, additional, Denzel, Dominik, additional, Schlump, Andrea, additional, Nickel, Kathrin, additional, Schiele, Miriam A., additional, Berger, Benjamin, additional, Prüss, Harald, additional, Urbach, Horst, additional, Domschke, Katharina, additional, Tebartz van Elst, Ludger, additional, and Endres, Dominique, additional

Published
2021
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15. Upregulation of sICAM-1 and sVCAM-1 Levels in the Cerebrospinal Fluid of Patients with Schizophrenia Spectrum Disorders

Author

Meixensberger, Sophie, primary, Kuzior, Hanna, additional, Fiebich, Bernd L., additional, Süß, Patrick, additional, Runge, Kimon, additional, Berger, Benjamin, additional, Nickel, Kathrin, additional, Denzel, Dominik, additional, Schiele, Miriam A., additional, Michel, Maike, additional, Maier, Simon, additional, Bechter, Karl, additional, Domschke, Katharina, additional, Tebartz van Elst, Ludger, additional, and Endres, Dominique, additional

Published
2021
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16. Anti-N-Methyl-D-Aspartate-Receptor Encephalitis: A 10-Year Follow-Up

Author

Meixensberger, Sophie, Tebartz van Elst, Ludger, Schweizer, Tina, Maier, Simon J., Prüss, Harald, Feige, Bernd, Denzel, Dominik, Runge, Kimon, Nickel, Kathrin, Matysik, Miriam, Venhoff, Nils, Domschke, Katharina, Urbach, Horst, Perlov, Evgeniy, and Endres, Dominique

Subjects
Psychiatry, psychotherapy, long-term, neuroleptics, follow-up, antibodies, Case Report, anti-N-methyl-D-aspartate-receptor encephalitis, ddc:610, catatonia
Abstract

Background: Anti-N-methyl-D-aspartate-receptor (NMDA-R) encephalitis is an autoimmune disease of the brain first described in 2007. The aim of this paper is to present a 10-year follow-up case history.Case Presentation: The authors present the case of a 39-year-old female patient who developed an anti-NMDA-R encephalitis in 2009 with predominant severe catatonic symptoms. Anti-inflammatory therapy led to the disappearance of catatonic symptoms and was discontinued during the course of the disease. After acute therapy, the patient achieved an almost full recovery presenting with ongoing discrete symptoms of sensory overload, subtle cognitive deficits, and fatigue/reduced energy levels. The follow-up investigation in 2019 showed inconspicuous findings in laboratory diagnostics and magnetic resonance imaging. Electroencephalography (EEG) analysis using independent component analysis detected left hemispherical spike-wave complexes and intermittent slowing. Regarding the sensory overload and reduced energy level, the patient benefited from low-dose neuroleptics (risperidone, amisulpride). In terms of sensory overload associated with experiences of panic, cognitive deficits and coping with the disease, she improved with cognitive behavioral therapy (CBT).Conclusion: Anti-inflammatory treatment led to almost full recovery with persistent disappearance of catatonic symptoms; however, a dysexecutive syndrome led to ongoing relevant problems with good response to low-dose atypical neuroleptics and CBT. The patient had persistent EEG alterations that indicated continuing neuronal network instability. Therefore, the case demonstrates the importance of multidisciplinary outpatient treatment following acute therapy for anti-NMDA-R encephalitis in patients with ongoing psychiatric deficits. For the symptomatic treatment of executive dysfunctions, “classical” psychiatric treatment may be helpful in the course of the disease.

Published
2020
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17. Upregulation of sICAM-1 and sVCAM-1 Levels in the Cerebrospinal Fluid of Patients with Schizophrenia Spectrum Disorders

Author

Meixensberger, Sophie, primary, Kuzior, Hanna, additional, Fiebich, Bernd, additional, Süß, Patrick, additional, Runge, Kimon, additional, Berger, Benjamin, additional, Nickel, Kathrin, additional, Denzel, Dominik, additional, Schiele, Miriam, additional, Michel, Maike, additional, Maier, Simon, additional, Bechter, Karl, additional, Domschke, Katharina, additional, Elst, Ludger Tebartz van, additional, and Endres, Dominique, additional

Published
2020
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18. Novel Antineuronal Autoantibodies With Somatodendritic Staining Pattern in a Patient With Autoimmune Psychosis

Author

Endres, Dominique, primary, Rauer, Sebastian, additional, Pschibul, Alexander, additional, Süß, Patrick, additional, Venhoff, Nils, additional, Runge, Kimon, additional, Feige, Bernd, additional, Denzel, Dominik, additional, Nickel, Kathrin, additional, Schweizer, Tina, additional, Maier, Simon, additional, Egger, Karl, additional, Domschke, Katharina, additional, Meyer, Philipp T., additional, Prüss, Harald, additional, and Tebartz van Elst, Ludger, additional

Published
2020
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19. Cerebrospinal Fluid Findings of 36 Adult Patients with Autism Spectrum Disorder

Author

Runge, Kimon, primary, Tebartz van Elst, Ludger, additional, Maier, Simon, additional, Nickel, Kathrin, additional, Denzel, Dominik, additional, Matysik, Miriam, additional, Kuzior, Hanna, additional, Robinson, Tilman, additional, Blank, Thomas, additional, Dersch, Rick, additional, Domschke, Katharina, additional, and Endres, Dominique, additional

Published
2020
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20. Anti-N-Methyl-D-Aspartate-Receptor Encephalitis: A 10-Year Follow-Up

Author

Meixensberger, Sophie, primary, Tebartz van Elst, Ludger, additional, Schweizer, Tina, additional, Maier, Simon J., additional, Prüss, Harald, additional, Feige, Bernd, additional, Denzel, Dominik, additional, Runge, Kimon, additional, Nickel, Kathrin, additional, Matysik, Miriam, additional, Venhoff, Nils, additional, Domschke, Katharina, additional, Urbach, Horst, additional, Perlov, Evgeniy, additional, and Endres, Dominique, additional

Published
2020
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21. Local glutamate in cingulate cortex subregions differentially correlates with affective network activations during face perception

Author

Denzel, Dominik, primary, Colic, Lejla, additional, Demenescu, Liliana Ramona, additional, Düring, Felicia, additional, Ristow, Inka, additional, Nießen, Hanna, additional, Hermann, Luisa, additional, Kaufmann, Jörn, additional, Dannlowski, Udo, additional, Frommer, Jörg, additional, Vogel, Matthias, additional, Li, Meng, additional, Lord, Anton, additional, and Walter, Martin, additional

Published
2020
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22. Anti-MOG autoantibody-associated schizophreniform psychosis.

Author

von Zedtwitz, Katharina, Matteit, Isabelle, Michel, Maike, Feige, Bernd, Runge, Kimon, Denzel, Dominik, Schlump, Andrea, Nickel, Kathrin, Schiele, Miriam A., Berger, Benjamin, Prüss, Harald, Urbach, Horst, Domschke, Katharina, Tebartz van Elst, Ludger, and Endres, Dominique

Subjects
MYELIN oligodendrocyte glycoprotein, ALPHA rhythm, IMMUNOGLOBULIN G, PSYCHOSES, CEREBROSPINAL fluid, AUTOIMMUNE diseases
Abstract

Objectives: Autoimmune mechanisms are related to disease development in a subgroup of patients with psychosis. The contribution of immunoglobulin G (IgG) antibodies against myelin oligodendrocyte glycoprotein (MOG) is mainly unclear in this context. Methods: Therefore, two patients with psychosis and anti-MOG antibodies – detected in fixed cell-based and live cell-based assays – are presented. Results: Patient 1 suffered from late-onset psychosis with singular white matter lesions in magnetic resonance imaging (MRI) and intermittent electroencephalography (EEG) slowing. Patient 2 suffered from a chronic paranoid–hallucinatory disorder with intermittent confusional states, non-specific white matter alterations on MRI, a disorganised alpha rhythm on EEG, and elevated cerebrospinal fluid protein. Both patients had anti-MOG antibody titres of 1 : 320 in serum (reference < 1 : 20). Conclusions: The arguments for and against a causal role for anti-MOG antibodies are discussed. The antibodies could be relevant, but due to moderate titres, they may have caused a rather 'subtle clinical picture' consisting of psychosis instead of 'classical' MOG encephalomyelitis. [ABSTRACT FROM AUTHOR]

Published
2022
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24. Expectation of sexual images of adults and children elicits differential dorsal anterior cingulate cortex activation in pedophilic sexual offenders and healthy controls

Author

Ristow, Inka, primary, Foell, Jens, additional, Kärgel, Christian, additional, Borchardt, Viola, additional, Li, Shijia, additional, Denzel, Dominik, additional, Witzel, Joachim, additional, Drumkova, Krasimira, additional, Beier, Klaus, additional, Kruger, Tillmann H.C., additional, Ponseti, Jorge, additional, Schiffer, Boris, additional, Schiltz, Kolja, additional, Walter, Henrik, additional, and Walter, Martin, additional

Published
2019
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