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407 results on '"Denvir, Martin A"'

1. Corticosteroid Corticosteroids Receptors in Cardiac Health and Disease

Author

Ivy, Jessica R., Gray, Gillian A., Holmes, Megan C., Denvir, Martin A., Chapman, Karen E., Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, Campbell, Moray J., editor, and Bevan, Charlotte L., editor

Published
2022
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2. Systematic hand-held echocardiography in patients hospitalised with acute coronary syndrome

Author

Geers, Jolien, primary, Balfour, Amy, additional, Molek, Patrycja, additional, Barron, Peter, additional, Botezatu, Simona, additional, Joshi, Shruti S, additional, White, Audrey, additional, Buchwald, Mikolaj, additional, Everett, Russell, additional, McCarley, Joanne, additional, Cusack, David, additional, Japp, Alan G, additional, Gibson, Patrick H, additional, Lang, Chris C E, additional, Stirrat, Colin, additional, Grubb, Neil R, additional, Bing, Rong, additional, Cruden, Nick L, additional, Denvir, Martin A, additional, Soliman Aboumarie, Hatem, additional, Cosyns, Bernard, additional, Newby, David E, additional, and Dweck, Marc R, additional

Published
2024
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3. Imaging the Developing Heart: Synchronized Timelapse Microscopy During Developmental Changes

Author

Nelson, Carl J., Buckley, Charlotte, Mullins, John J., Denvir, Martin A., and Taylor, Jonathan

Subjects
Quantitative Biology - Tissues and Organs
Abstract

How do you use imaging to analyse the development of the heart, which not only changes shape but also undergoes constant, high-speed, quasi-periodic changes? We have integrated ideas from prospective and retrospective optical gating to capture long-term, phase-locked developmental time-lapse videos. In this paper we demonstrate the success of this approach over a key developmental time period: heart looping, where large changes in heart shape prevent previous prospective gating approaches from capturing phase-locked videos. We use the comparison with other approaches to in vivo heart imaging to highlight the importance of collecting the most appropriate data for the biological question., Comment: Carl J. Nelson and Charlotte Buckley and John J. Mullins and Martin A. Denvir and Jonathan Taylor, "Imaging the Developing Heart: Synchronized Timelapse Microscopy During Developmental Changes", Proc. SPIE (10499), 10499-41 (2018). Copyright 2018 Society of Photo Optical Instrumentation Engineers (SPIE)

Published
2018
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5. Allopurinol versus usual care in UK patients with ischaemic heart disease (ALL-HEART): a multicentre, prospective, randomised, open-label, blinded-endpoint trial

Author

Ahmed, Husnat, Arthur, Peter, Aziz, Jane, Barnes, Lawrence, Boyle, Sarah, Brighton, Tom, Brown, Morris, Caulfield, Mark, Dawson, Jesse, Denvir, Martin, Doney, Alexander SF, Doshi, Sagar, Dryburgh, Moira, Eddleston, Michael, Finlayson, Jim, Fuat, Ahmet, Furnace, Jacqueline, Grieve, JW Kerr, Guthrie, Greg, Ham, Sharon, Isaard, Emma, Jennings, Claudine, Johnson, Richard, Kerr, Claire, Khan, Sohail, Krishnan, Kailash, Long, Susan, Mackintosh, Anne, Macleod, Mary Joan, McCormack, Terry, McEleny, Paul, Morar, Monique, Nadir, Adnan, Newby, David, Petrie, Colin, Preiss, David, Ralston, Stuart, Randall, Marc, Routledge, Helen, Shakir, Saad, Sharma, Raj, Shepherd, Bridget, Sims, Don, Snedden, Gordon, Trevelyan, Jasper, Weir, Christopher, Weir, Robin, Wetherall, Kirsty, Wilson, Robbie, Wilson, Adam, Zutis, Kris, Mackenzie, Isla S, Hawkey, Christopher J, Ford, Ian, Greenlaw, Nicola, Pigazzani, Filippo, Rogers, Amy, Struthers, Allan D, Begg, Alan G, Wei, Li, Avery, Anthony J, Taggar, Jaspal S, Walker, Andrew, Duce, Suzanne L, Barr, Rebecca J, Dumbleton, Jennifer S, Rooke, Evelien D, Townend, Jonathan N, Ritchie, Lewis D, and MacDonald, Thomas M

Published
2022
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7. 18F-Sodium Fluoride Positron Emission Tomography and Computed Tomography in Acute Aortic Syndrome

Author

Syed, Maaz B.J., Fletcher, Alexander J., Debono, Samuel, Forsythe, Rachel O., Williams, Michelle C., Dweck, Marc R., Shah, Anoop S.V., Macaskill, Mark G., Tavares, Adriana, Denvir, Martin A., Lim, Kelvin, Wallace, William A., Kaczynski, Jakub, Clark, Tim, Sellers, Stephanie L., Masson, Neil, Falah, Orwa, Chalmers, Roderick T.A., Tambyraja, Andrew L., van Beek, Edwin J.R., and Newby, David E.

Published
2022
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17. Cardiac sarcoplasmic reticulum function in heart failure

Author

Denvir, Martin

Subjects
616.1
Abstract

Heart failure is characterised by abnormalities of myocardial systolic and diastolic function. While there are changes in the structure of the heart which could account, in part, for these abnormalities, there is strong evidence to suggest that the regulation of calcium within the failing cardiac myocyte is abnormal. A diminished ability to release and sequester calcium could give rise to such contractile abnormalities and so the sarcoplasmic reticulum (SR), as the main site for calcium uptake and release, is the major focus of study in this thesis. Two rabbit models of heart failure were studied: adriamycin-induced cardiomyopathy and coronary artery ligation. The adriamycin-treated animals were studied 2 weeks after stopping 8 weeks of chronic intravenous administration. The coronary ligation animals were studied in two groups : 8 weeks after ligation and 15 weeks after ligation. The effects of down- regulation of adrenoreceptors on SR function was studied in a rabbit model following 7 days continuous administration of isoprenaline by mini-osmotic pump. Lastly, human ventricular trabeculae were studied from patients undergoing cardiac transplantation and are presented as a separate chapter. The severity of heart failure was assessed in each rabbit by echocardiography and by invasive measurement of cardiac output and left ventricular pressures. The preparation chosen to study the SR was the saponin-treated cardiac ventricular trabecula. This preparation has a number of advantages in that it leaves the SR anatomically undisrupted, the SR can load and leak calcium in a physiological way, the permeabilised sarcolemma allows free access to drugs and chemicals and the myofilaments may be assessed both in association with the SR and independently following treatment with the detergent Triton-X100. Furthermore, in our hands, this technique is very reliable and reproducible which is extremely important since very few animals which started the protocol, for any of the models, failed to produce results from the saponin-treated fibres. This has important implications for animal suffering. Sarcoplasmic reticulum function was assessed in the rabbit model of adriamycin-induced cardiomyopathy. The method for inducing cardiomyopathy is described in chapter 2 (methods 1) and the results are described in chapter 3. Unfortunately few animals with significant left ventricular dysfunction were produced but those with ejection fractions of less than 45% demonstrated enhanced SR Calcium loading compared with saline-treated controls and with adriamycin treated animals with higher ejection fractions. The ability of the myofilaments to produce force was unaffected by chronic treatment with adriamycin and the calcium responsiveness of the myofilaments was also unaffected by adriamycin treatment. 8 weeks after coronary ligation, rabbits with significant left ventricular dysfunction demonstrated enhanced SR calcium uptake compared with controls. A group of ligation animals with less severe left ventricular dysfunction, assessed by a scoring system, also demonstrated enhanced SR calcium loading but the difference between this group and sham-operated controls was less marked. Additionally , this enhanced SR calcium loading was correlated with a number of indices of heart failure including ejection fraction, left ventricular end-diastolic pressure and resting cardiac output. Enhanced SR calcium loading was associated with an increased predisposition to calcium overload, revealed as spontaneous tension oscillations. These oscillations were observed more frequently in the ligated animals and at lower loading calcium concentrations than in the control animals. This pattern of SR loading was observed in both left and right ventricular preparations although the greatest increase in SR loading was observed in the left ventricle. The ability of the myofilaments to produce force was not altered in the left ventricle but there was a fall in the maximum force produced by trabeculae from the right ventricle in the ligated group. The calcium responsiveness of the myofilaments was not different between groups. Chapter 4 examines SR calcium loading 15 weeks after coronary ligation. In these animals there was no significant difference in SR calcium loading ability between ligation and control trabeculae. The ligated animals demonstrated significant left ventricular dysfunction but this was not more severe than that observed in 8 week animals. Myofilament force production was unaltered as was calcium responsiveness of the myofilaments. Chapter 6 examines possible changes in the SR calcium release mechanism. There was no difference in the sensitivity of the mechanism of caffeine- induced calcium release in ligation animals compared with controls. Trabeculae from ligation animals appeared more sensitive to the calcium channel blocking agent, ryanodine, when applied during sustained oscillations. In a separate set of experiments SR calcium leak was assessed.

Published
1994

19. Allopurinol versus usual care in UK patients with ischaemic heart disease (ALL-HEART): a multicentre, prospective, randomised, open-label, blinded-endpoint trial

Author

Mackenzie, Isla S, primary, Hawkey, Christopher J, additional, Ford, Ian, additional, Greenlaw, Nicola, additional, Pigazzani, Filippo, additional, Rogers, Amy, additional, Struthers, Allan D, additional, Begg, Alan G, additional, Wei, Li, additional, Avery, Anthony J, additional, Taggar, Jaspal S, additional, Walker, Andrew, additional, Duce, Suzanne L, additional, Barr, Rebecca J, additional, Dumbleton, Jennifer S, additional, Rooke, Evelien D, additional, Townend, Jonathan N, additional, Ritchie, Lewis D, additional, MacDonald, Thomas M, additional, Ahmed, Husnat, additional, Arthur, Peter, additional, Aziz, Jane, additional, Barnes, Lawrence, additional, Boyle, Sarah, additional, Brighton, Tom, additional, Brown, Morris, additional, Caulfield, Mark, additional, Dawson, Jesse, additional, Denvir, Martin, additional, Doney, Alexander SF, additional, Doshi, Sagar, additional, Dryburgh, Moira, additional, Eddleston, Michael, additional, Finlayson, Jim, additional, Fuat, Ahmet, additional, Furnace, Jacqueline, additional, Grieve, JW Kerr, additional, Guthrie, Greg, additional, Ham, Sharon, additional, Isaard, Emma, additional, Jennings, Claudine, additional, Johnson, Richard, additional, Kerr, Claire, additional, Khan, Sohail, additional, Krishnan, Kailash, additional, Long, Susan, additional, Mackintosh, Anne, additional, Macleod, Mary Joan, additional, McCormack, Terry, additional, McEleny, Paul, additional, Morar, Monique, additional, Nadir, Adnan, additional, Newby, David, additional, Petrie, Colin, additional, Preiss, David, additional, Ralston, Stuart, additional, Randall, Marc, additional, Routledge, Helen, additional, Shakir, Saad, additional, Sharma, Raj, additional, Shepherd, Bridget, additional, Sims, Don, additional, Snedden, Gordon, additional, Trevelyan, Jasper, additional, Weir, Christopher, additional, Weir, Robin, additional, Wetherall, Kirsty, additional, Wilson, Robbie, additional, Wilson, Adam, additional, and Zutis, Kris, additional

Published
2022
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21. Macrophages trigger cardiomyocyte proliferation by increasing epicardial vegfaa expression during larval zebrafish heart regeneration

Author

Bruton, Finnius A., primary, Kaveh, Aryan, additional, Ross-Stewart, Katherine M., additional, Matrone, Gianfranco, additional, Oremek, Magdalena E.M., additional, Solomonidis, Emmanouil G., additional, Tucker, Carl S., additional, Mullins, John J., additional, Lucas, Christopher D., additional, Brittan, Mairi, additional, Taylor, Jonathan M., additional, Rossi, Adriano G., additional, and Denvir, Martin A., additional

Published
2022
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23. Patient selection for high sensitivity cardiac troponin testing and diagnosis of myocardial infarction: prospective cohort study

Author

Shah, Anoop S V, Sandoval, Yader, Noaman, Ala, Sexter, Anne, Vaswani, Amar, Smith, Stephen W, Gibbins, Mathew, Griffiths, Megan, Chapman, Andrew R, Strachan, Fiona E, Anand, Atul, Denvir, Martin A, Adamson, Philip D, DʼSouza, Michelle S, Gray, Alasdair J, McAllister, David A, Newby, David E, Apple, Fred S, and Mills, Nicholas L

Published
2017
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31. Macrophages stimulate epicardial VEGFaa expression to trigger cardiomyocyte proliferation in larval zebrafish heart regeneration

Author

Bruton, Finnius A., primary, Kaveh, Aryan, additional, Ross-Stewart, Katherine M., additional, Matrone, Gianfranco, additional, Oremek, Magdalena E.M., additional, Solomonidis, Emmanouil G., additional, Tucker, Carl S., additional, Mullins, John J., additional, Brittan, Mairi, additional, Taylor, Jonathan M., additional, Rossi, Adriano G., additional, and Denvir, Martin A., additional

Published
2021
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32. 161 18F-sodium fluoride positron emission tomography in acute aortic syndrome

Author

Syed, Maaz, primary, Fletcher, Alexander, additional, Debono, Samuel, additional, Forsythe, Rachael, additional, Williams, Michelle, additional, Dweck, Marc, additional, Tavares, Adriana, additional, Macaskill, Mark, additional, Shah, Anoop, additional, Denvir, Martin, additional, Lim, Kelvin, additional, Wallace, William, additional, Kaczynski, Jakub, additional, Clark, Tim, additional, Sellers, Stephanie, additional, Masson, Neil, additional, Falah, Orwa, additional, Chalmers, Roderick, additional, Tambyraja, Andrew, additional, van Beek, Edwin, additional, and Newby, David, additional

Published
2021
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36. 18F-SODIUM FLUORIDE POSITRON EMISSION TOMOGRAPHY / COMPUTED TOMOGRAPHY IN ACUTE AORTIC SYNDROME

Author

Syed, Maaz J., primary, Fletcher, Alexander, additional, Debono, Samuel, additional, Forsythe, Rachael, additional, Williams, Michelle, additional, Tavarez, Adriana, additional, Wallace, William A., additional, Denvir, Martin, additional, Falah, Orwa, additional, Tambyraja, Andrew, additional, Chalmers, Roderick, additional, Van Beek, Edwin, additional, Dweck, Marc, additional, and Newby, David, additional

Published
2021
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37. Cardiac Energetics Before, During, and After Anthracycline-Based Chemotherapy in Breast Cancer Patients Using 31P Magnetic Resonance Spectroscopy: A Pilot Study

Author

Macnaught, Gillian, primary, Oikonomidou, Olga, additional, Rodgers, Christopher T., additional, Clarke, William, additional, Cooper, Annette, additional, McVicars, Heather, additional, Hayward, Larry, additional, Mirsadraee, Saeed, additional, Semple, Scott, additional, and Denvir, Martin A., additional

Published
2021
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40. Live imaging of the immune response to heart injury in larval zebrafish reveals a multi-stage model of neutrophil and macrophage migration

Author

Kaveh, Aryan, Bruton, Finnius A., Buckley, Charlotte, Oremek, Magdalena E.M., Tucker, Carl S., Mullins, John J, Taylor, Jonathan M., Rossi, Adriano G, and Denvir, Martin A

Abstract

Neutrophils and macrophages are crucial effectors and modulators of repair and regeneration following myocardial infarction, but they cannot be easily observed in vivo in mammalian models. Hence many studies have utilized larval zebrafish injury models to examine neutrophils and macrophages in their tissue of interest. However, to date the migratory patterns and ontogeny of these recruited cells is unknown. In this study, we address this need by comparing our larval zebrafish model of cardiac injury to the archetypal tail fin injury model. Our in vivo imaging allowed comprehensive mapping of neutrophil and macrophage migration from primary hematopoietic sites, to the wound. Early following injury there is an acute phase of neutrophil recruitment that is followed by sustained macrophage recruitment. Both cell types are initially recruited locally and subsequently from distal sites, primarily the caudal hematopoietic tissue (CHT). Once liberated from the CHT, some neutrophils and macrophages enter circulation, but most use abluminal vascular endothelium to crawl through the larva. In both injury models the innate immune response resolves by reverse migration, with very little apoptosis or efferocytosis of neutrophils. Furthermore, our in vivo imaging led to the finding of a novel wound responsive mpeg1+ neutrophil subset, highlighting previously unrecognized heterogeneity in neutrophils. Our study provides a detailed analysis of the modes of immune cell migration in larval zebrafish, paving the way for future studies examining tissue injury and inflammation.

Published
2020

41. Implications of serial measurements of natriuretic peptides in heart failure: insights from BIOSTAT‐CHF

Author

Israr, Muhammad Zubair, Salzano, Andrea, Yazaki, Yoshiyuki, Voors, Adriaan A., Ouwerkerk, Wouter, Anker, Stefan D., Cleland, John G.F., Dickstein, Kenneth, Metra, Marco, Samani, Nilesh J., Ng, Leong L., Suzuki, Toru, Anker, S.D., Cleland, J.G., Dickstein, K., Filippatos, G., Hillege, H.L., Lang, C.C., Metra, M., Ng, L., Ponikowski, P., Samani, N., Veldhuisen, D.J., Zannad, F., Zwinderman, A.H., Bulgari, M., Lombardi, C., Carubelli, V., Lazzarini, Valentina, Rovetta, Riccardo, Magatelli, Marco, Castrini, Isotta, Bettari, Luca, Cosmi, Franco, Correale, Michele, Di Biase, Matteo, Fratini, Simona, Limongelli, Giuseppe, Parati, Gianfranco, Penco, Maria, Zaccà, Valerio, Voors, A.A., Haehling, S., Ebner, N., Springer, J., Diek, M., Lainscak, M, Koekemoer, Andrea, Papakonstantinou, Manolo, Hall, Leanne M, Romaine, Simon R, Romaine, Christopher P, Thompson, John R, Harst, Pim, Jones, D.J.L., Willingale, R., Cao, H.T., Sandhu, J.K., Quinn, P.A., Patel, H., Auluck, J., Hakimi, A., Lennep, H.W.O. Roeters, Liem, A., Ghraboghly, A., Dunselman, P.H.J.M., Hoogslag, P.A.M., Linssen, G.C.M., Van Haelst, P.L., Lok, D.J., Zinzius, P.Y., Godenir, J.P., Madeleine, CH Marie, Thisse, J.Y., Martelet, M., Deforet, M.F., Delarche, N., Leduc, J.J., Galinier, M., Neuder, Y., Eschalier, R., Clerfond, G., Benetos, A., Khalife, K., Düngen, H., Petrović, V., Bratislav, A., Otašević, P., Trifunović, N., Seferović, P. M., Pavlović, M., Nešković, A.N., Radovanović, S., Lainščak, M., Ravnikar, T., Dimković, S., Kolokathis, F., Karavidas, A., Patsilinakos, S., Kitsiou, M., Kyriakidis, Z., Makridis, P., Mantas, I., Douras, A., Rentoukas, E., Barbetseas, J., Karvounis, H., Penco, M., Zacà, V., Calabrò, R., Di Biase, M., Parati, G., Cosmi, F., Dahlström, U., Lund, L.H., Persson, H., Otterstad, J.E., Jortveit, J., Hole, T.H.O., Gjertsen, E., Aaser, E., Berkowski, P., Ogorek, M., Jurczyk, A., Sokolowski, A., Szafran, B., Hof, M.H.P., Ouwerkerk, W., Lang, C C, Choy, A M, Doney, A, Palmer, C, Morris, A, Guthrie, B, Parry, H, Tavendale, R, Heather, Duncan, Rutherford, Lynn, Waldie, Helen, Mohan, Mohanpradeep, Baig, Fatima, Hopkinson, Pippa, Levin, Daniel, Francis, Mark, Bryson, Valerie, Dawson, Dana, Frenneaux, Michael, Denvir, Martin, Flint, Laura, Robertson, Shirley, Gardner, Roy, McAdam, Marion, McGovern, Kirsty, McMurray, J., Campbell, Ross, and Cannon, Jane

Subjects
R1
Abstract

No abstract available.

Published
2020

42. Additional file 1 of Frailty assessment and risk prediction by GRACE score in older patients with acute myocardial infarction

Author

Anand, Atul, Cudmore, Sarah, Robertson, Shirley, Stephen, Jacqueline, Haga, Kristin, Weir, Christopher J., Murray, Scott A., Boyd, Kirsty, Gunn, Julian, Javaid Iqbal, MacLullich, Alasdair, Shenkin, Susan D., Fox, Keith A. A., Mills, Nicholas, and Denvir, Martin A.

Abstract

Additional file 1. Supplementary material including 4 additional data tables and 4 additional figures as referenced in the results section.

Published
2020
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43. Supplementary_File – Supplemental material for Adjudication of cardiovascular events in patients with chronic obstructive pulmonary disease: SUMMIT trial

Author

Wise, Robert A, Anderson, Julie A, Amarenco, Pierre, Cowans, Nicholas J, Crim, Courtney, Denvir, Martin A, Gomez, Camilo R, Jones, Matthew PA, Morris, Andrea, Niewoehner, Dennis, and Yates, Julie C

Subjects
FOS: Clinical medicine, 160807 Sociological Methodology and Research Methods, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, FOS: Sociology
Abstract

Supplemental material, Supplementary_File for Adjudication of cardiovascular events in patients with chronic obstructive pulmonary disease: SUMMIT trial by Robert A Wise, Julie A Anderson, Pierre Amarenco, Nicholas J Cowans, Courtney Crim, Martin A Denvir, Camilo R Gomez, Matthew PA Jones, Andrea Morris, Dennis Niewoehner and Julie C Yates in Clinical Trials

Published
2020
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44. Macrophages Stimulate Epicardial vegfaa Expression to Trigger Cardiomyocyte Proliferation in Larval Zebrafish Heart Regeneration

Author

Bruton, Finnius Austin, primary, Kaveh, Aryan, additional, Ross-Stewart, Katherine M., additional, Matrone, Gianfranco, additional, Oremek, Magdalena E.M., additional, Solomonidis, Emmanouil G., additional, Tucker, Carl S., additional, Mullins, John J., additional, Brittan, Mairi, additional, Taylor, Jonathan M., additional, Rossi, Adriano G., additional, and Denvir, Martin A., additional

Published
2021
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45. Cardiac Energetics Before, During and After Anthracycline-based Chemotherapy in Breast Cancer Patients Using 31P Magnetic Resonance Spectroscopy: A Pilot Study

Author

Macnaught, Gillian, primary, Oikonomidou, Olga, additional, Rodgers, Christopher T., additional, Clarke, William, additional, Cooper, Annette, additional, McVicars, Heather, additional, Hayward, Larry, additional, Mirsadraee, Saeed, additional, Semple, Scott, additional, and Denvir, Martin A, additional

Published
2020
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50. Selective Cdk9 inhibition resolves neutrophilic inflammation and enhances cardiac regeneration in larval zebrafish.

Author

Kaveh, Aryan, Bruton, Finnius A., Oremek, Magdalena E. M., Tucker, Carl S., Taylor, Jonathan M., Mullins, John J., Rossi, Adriano G., and Denvir, Martin A.

Subjects
CARDIAC regeneration, BRACHYDANIO, NEUTROPHILS, HEART injuries, FLUORESCENCE microscopy, INFLAMMATION, MYOCARDIAL infarction
Abstract

Sustained neutrophilic inflammation is detrimental for cardiac repair and associated with adverse outcomes following myocardial infarction (MI). An attractive therapeutic strategy to treat MI is to reduce or remove infiltrating neutrophils to promote downstream reparative mechanisms. CDK9 inhibitor compounds enhance the resolution of neutrophilic inflammation; however, their effects on cardiac repair/regeneration are unknown. We have devised a cardiac injury model to investigate inflammatory and regenerative responses in larval zebrafish using heartbeat-synchronised light-sheet fluorescence microscopy. We used this model to test two clinically approved CDK9 inhibitors, AT7519 and flavopiridol, examining their effects on neutrophils, macrophages and cardiomyocyte regeneration. We found that AT7519 and flavopiridol resolve neutrophil infiltration by inducing reverse migration from the cardiac lesion. Although continuous exposure to AT7519 or flavopiridol caused adverse phenotypes, transient treatment accelerated neutrophil resolution while avoiding these effects. Transient treatment with AT7519, but not flavopiridol, augmented woundassociated macrophage polarisation, which enhanced macrophagedependent cardiomyocyte number expansion and the rate of myocardial wound closure. Using cdk9-/-knockout mutants, we showed that AT7519 is a selective CDK9 inhibitor, revealing the potential of such treatments to promote cardiac repair/regeneration. [ABSTRACT FROM AUTHOR]

Published
2022
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