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451 results on '"Denost, Quentin"'

1. Imaging in pelvic exenteration—a multidisciplinary practice guide from the ESGAR-SAR-ESUR-PelvEx collaborative group

Author

Nougaret, Stephanie, Lambregts, Doenja M. J., Beets, Geerard L., Beets-Tan, Regina G. H., Blomqvist, Lennart, Burling, David, Denost, Quentin, Gambacorta, Maria A., Gui, Benedetta, Klopp, Ann, Lakhman, Yulia, Maturen, Kate E., Manfredi, Riccardo, Petkovska, Iva, Russo, Luca, Shinagare, Atul B., Stephenson, James A., Tolan, Damian, Venkatesan, Aradhana M., Quyn, Aaron J., and Forstner, Rosemarie

Published
2024
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4. Impact of microsatellite status in early-onset colonic cancer.

Author

Zaborowski, Alexandra M, Adamina, Ahmed Abdile Michel, Aigner, Felix, d'Allens, Laura, Allmer, Caterina, Álvarez, Andrea, Anula, Rocio, Andric, Mihailo, Bach, Sam Atallah Simon, Bala, Miklosh, Barussaud, Marie, Bausys, Augustinas, Beggs, Andrew, Bellolio, Felipe, Bennett, Melissa-Rose, Berdinskikh, Anton, Bevan, Vicki, Biondo, Sebastiano, Bislenghi, Gabriele, Bludau, Marc, Brouwer, Nelleke, Brown, Carl, Bruns, Christiane, Buchanan, Daniel D, Buchwald, Pamela, Burger, Jacobus WA, Burlov, Nikita, Campanelli, Michela, Capdepont, Maylis, Carvello, Michele, Chew, Hwee-Hoon, Christoforidis, Dimitri, Clark, David, Climent, Marta, Collinson, Rowan, Cologne, Kyle G, Contreras, Tomas, Croner, Roland, Daniels, Ian R, Dapri, Giovanni, Davies, Justin, Delrio, Paolo, Denost, Quentin, Deutsch, Michael, Dias, Andre, D’Hoore, André, Drozdov, Evgeniy, Duek, Daniel, Dunlop, Malcolm, Dziki, Adam, Edmundson, Aleksandra, Efetov, Sergey, El-Hussuna, Alaa, Elliot, Brodie, Emile, Sameh, Espin, Eloy, Evans, Martyn, Faes, Seraina, Faiz, Omar, Figueiredo, Nuno, Fleming, Fergal, Foppa, Caterina, Fowler, George, Frasson, Matteo, Forgan, Tim, Frizelle, Frank, Gadaev, Shamil, Gellona, Jose, Glyn, Tamara, Goran, Barisic, Greenwood, Emma, Guren, Marianne G, Guillon, Stephanie, Gutlic, Ida, Hahnloser, Dieter, Hampel, Heather, Hanly, Ann, Hasegawa, Hirotoshi, Iversen, Lene Hjerrild, Hill, Andrew, Hill, James, Hoch, Jiri, Hompes, Roel, Hurtado, Luis, Iaquinandi, Fabiano, Imbrasaite, Ugne, Islam, Rumana, Jafari, Mehrenah D, Salido, Andrea Jiménez, Jiménez-Toscano, Marta, Kanemitsu, Yukihide, Karachun, Aleksei, Karimuddin, Ahmer A, Keller, Deborah S, Kelly, Justin, Kennelly, Rory, Khrykov, Gleb, Kocian, Peter, Koh, Cherry, and Kok, Neils

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, Genetic Testing, Digestive Diseases, Genetics, Clinical Research, Colo-Rectal Cancer, Aetiology, 2.1 Biological and endogenous factors, Colonic Neoplasms, Colorectal Neoplasms, Humans, Microsatellite Instability, Microsatellite Repeats, Mutation, Prognosis, Proto-Oncogene Proteins B-raf, Proto-Oncogene Proteins p21(ras), REACCT Collaborative, Medical and Health Sciences, Surgery, Clinical sciences
Abstract

BackgroundThe molecular profile of early-onset colonic cancer is undefined. This study evaluated clinicopathological features and oncological outcomes of young patients with colonic cancer according to microsatellite status.MethodsAnonymized data from an international collaboration were analysed. Criteria for inclusion were patients younger than 50 years diagnosed with stage I-III colonic cancer that was surgically resected. Clinicopathological features, microsatellite status, and disease-specific outcomes were evaluated.ResultsA total of 650 patients fulfilled the criteria for inclusion. Microsatellite instability (MSI) was identified in 170 (26.2 per cent), whereas 480 had microsatellite-stable (MSS) tumours (relative risk of MSI 2.5 compared with older patients). MSI was associated with a family history of colorectal cancer and lesions in the proximal colon. The proportions with pathological node-positive disease (45.9 versus 45.6 per cent; P = 1.000) and tumour budding (20.3 versus 20.5 per cent; P = 1.000) were similar in the two groups. Patients with MSI tumours were more likely to have BRAF (22.5 versus 6.9 per cent; P < 0.001) and KRAS (40.0 versus 24.2 per cent; P = 0.006) mutations, and a hereditary cancer syndrome (30.0 versus 5.0 per cent; P < 0.001; relative risk 6). Five-year disease-free survival rates in the MSI group were 95.0, 92.0, and 80.0 per cent for patients with stage I, II, and III tumours, compared with 88.0, 88.0, and 65.0 per cent in the MSS group (P = 0.753, P = 0.487, and P = 0.105 respectively).ConclusionPatients with early-onset colonic cancer have a high risk of MSI and defined genetic conditions. Those with MSI tumours have more adverse pathology (budding, KRAS/BRAF mutations, and nodal metastases) than older patients with MSI cancers.

Published
2022

7. Post-Operative Functional Outcomes in Early Age Onset Rectal Cancer

Author

Collaborative, REACCT, O’Connell, Lauren V, Zaborowski, Alexandra M, Abdile, Ahmed, Adamina, Michel, Aigner, Felix, d’Allens, Laura, Allmer, Caterina, Álvarez, Andrea, Anula, Rocio, Andric, Mihailo, Bach, Sam Atallah Simon, Bala, Miklosh, Barussaud, Marie, Bausys, Augustinas, Beggs, Andrew, Bellolio, Felipe, Bennett, Melissa-Rose, Bevan, Vicki, Biondo, Sebastiano, Bislenghi, Gabriele, Bludau, Marc, Brown, Carl, Bruns, Christiane, Buchanan, Daniel D, Buchwald, Pamela, Burger, Jacobus WA, Burlov, Nikita, Campanelli, Michela, Capdepont, Maylis, Carvello, Michele, Chew, Hwee-Hoon, Christoforidis, Dimitri, Clark, David, Climent, Marta, Collinson, Rowan, Cologne, Kyle G, Contreras, Tomas, Croner, Roland, Daniels, Ian R, Dapri, Giovanni, Davies, Justin, Delrio, Paolo, Denost, Quentin, Deutsch, Michael, Dias, Andre, D’Hoore, André, Drozdov, Evgeniy, Duek, Daniel, Dunlop, Malcolm, Dziki, Adam, Edmundson, Aleksandra, Efetov, Sergey, El-Hussuna, Alaa, Elliott, Brodie, Emile, Sameh, Espin-Basany, Eloy, Evans, Martyn, Faes, Seraina, Faiz, Omar, Figueiredo, Nuno, Fleming, Fergal, Foppa, Caterina, Fowler, George, Frasson, Matteo, Forgan, Tim, Frizelle, Frank, Gadaev, Shamil, Gellona, Jose, Glyn, Tamara, Goran, Barisic, Greenwood, Emma, Guren, Marianne G, Guillon, Stephanie, Gutlic, Ida, Hahnloser, Dieter, Hampel, Heather, Hanly, Ann, Hasegawa, Hirotoshi, Iversen, Lene Hjerrild, Hill, Andrew, Hill, James, Hoch, Jiri, Hompes, Roel, Hurtado, Luis, Iaquinandi, Fabiano, Imbrasaite, Ugne, Islam, Rumana, Jafari, Mehrenah D, Salido, Andrea Jiménez, Jiménez-Toscano, Marta, Kanemitsu, Yukihide, Karachun, Aleksei, Karimuddin, Ahmer A, Keller, Deborah S, Kelly, Justin, Kennelly, Rory, Khrykov, Gleb, Kocian, Petr, and Koh, Cherry

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Rehabilitation, Cancer, Clinical Research, Digestive Diseases, Good Health and Well Being, REACCT Collaborative, early onset rectal cancer, functional outcome, patient reported outcome, rectal cancer, young rectal cancer, Clinical sciences, Oncology and carcinogenesis
Abstract

BackgroundImpairment of bowel, urogenital and fertility-related function in patients treated for rectal cancer is common. While the rate of rectal cancer in the young (

Published
2022

8. Characteristics of Early-Onset vs Late-Onset Colorectal Cancer

Author

Collaborative, REACCT, Zaborowski, Alexandra M, Abdile, Ahmed, Adamina, Michel, Aigner, Felix, d’Allens, Laura, Allmer, Caterina, Álvarez, Andrea, Anula, Rocio, Andric, Mihailo, Atallah, Sam, Bach, Simon, Bala, Miklosh, Barussaud, Marie, Bausys, Augustinas, Bebington, Brendan, Beggs, Andrew, Bellolio, Felipe, Bennett, Melissa-Rose, Berdinskikh, Anton, Bevan, Vicki, Biondo, Sebastiano, Bislenghi, Gabriele, Bludau, Marc, Boutall, Adam, Brouwer, Nelleke, Brown, Carl, Bruns, Christiane, Buchanan, Daniel D, Buchwald, Pamela, Burger, Jacobus WA, Burlov, Nikita, Campanelli, Michela, Capdepont, Maylis, Carvello, Michele, Chew, Hwee-Hoon, Christoforidis, Dimitri, Clark, David, Climent, Marta, Cologne, Kyle G, Contreras, Tomas, Croner, Roland, Daniels, Ian R, Dapri, Giovanni, Davies, Justin, Delrio, Paolo, Denost, Quentin, Deutsch, Michael, Dias, Andre, D’Hoore, André, Drozdov, Evgeniy, Duek, Daniel, Dunlop, Malcolm, Dziki, Adam, Edmundson, Aleksandra, Efetov, Sergey, El-Hussuna, Alaa, Elliot, Brodie, Emile, Sameh, Espin, Eloy, Evans, Martyn, Faes, Seraina, Faiz, Omar, Fleming, Fergal, Foppa, Caterina, Fowler, George, Frasson, Matteo, Figueiredo, Nuno, Forgan, Tim, Frizelle, Frank, Gadaev, Shamil, Gellona, Jose, Glyn, Tamara, Gong, Jianping, Goran, Barisic, Greenwood, Emma, Guren, Marianne G, Guillon, Stephanie, Gutlic, Ida, Hahnloser, Dieter, Hampel, Heather, Hanly, Ann, Hasegawa, Hirotoshi, Iversen, Lene Hjerrild, Hill, Andrew, Hill, James, Hoch, Jiri, Hoffmeister, Michael, Hompes, Roel, Hurtado, Luis, Iaquinandi, Fabiano, Imbrasaite, Ugne, Islam, Rumana, Jafari, Mehrenah Dorna, Kanemitsu, Yukihide, Karachun, Aleksei, Karimuddin, Ahmer A, Keller, Deborah S, Kelly, Justin, and Kennelly, Rory

Subjects
Aging, Nutrition, Digestive Diseases, Cancer, Colo-Rectal Cancer, Genetics, Clinical Research, Prevention, 2.1 Biological and endogenous factors, Aetiology, Good Health and Well Being, Adult, Age of Onset, Colorectal Neoplasms, Humans, Incidence, Middle Aged, Risk Factors, REACCT Collaborative
Abstract

ImportanceThe incidence of early-onset colorectal cancer (younger than 50 years) is rising globally, the reasons for which are unclear. It appears to represent a unique disease process with different clinical, pathological, and molecular characteristics compared with late-onset colorectal cancer. Data on oncological outcomes are limited, and sensitivity to conventional neoadjuvant and adjuvant therapy regimens appear to be unknown. The purpose of this review is to summarize the available literature on early-onset colorectal cancer.ObservationsWithin the next decade, it is estimated that 1 in 10 colon cancers and 1 in 4 rectal cancers will be diagnosed in adults younger than 50 years. Potential risk factors include a Westernized diet, obesity, antibiotic usage, and alterations in the gut microbiome. Although genetic predisposition plays a role, most cases are sporadic. The full spectrum of germline and somatic sequence variations implicated remains unknown. Younger patients typically present with descending colonic or rectal cancer, advanced disease stage, and unfavorable histopathological features. Despite being more likely to receive neoadjuvant and adjuvant therapy, patients with early-onset disease demonstrate comparable oncological outcomes with their older counterparts.Conclusions and relevanceThe clinicopathological features, underlying molecular profiles, and drivers of early-onset colorectal cancer differ from those of late-onset disease. Standardized, age-specific preventive, screening, diagnostic, and therapeutic strategies are required to optimize outcomes.

Published
2021

9. Characteristics of Early-Onset vs Late-Onset Colorectal Cancer: A Review.

Author

REACCT Collaborative, Zaborowski, Alexandra M, Abdile, Ahmed, Adamina, Michel, Aigner, Felix, d'Allens, Laura, Allmer, Caterina, Álvarez, Andrea, Anula, Rocio, Andric, Mihailo, Atallah, Sam, Bach, Simon, Bala, Miklosh, Barussaud, Marie, Bausys, Augustinas, Bebington, Brendan, Beggs, Andrew, Bellolio, Felipe, Bennett, Melissa-Rose, Berdinskikh, Anton, Bevan, Vicki, Biondo, Sebastiano, Bislenghi, Gabriele, Bludau, Marc, Boutall, Adam, Brouwer, Nelleke, Brown, Carl, Bruns, Christiane, Buchanan, Daniel D, Buchwald, Pamela, Burger, Jacobus WA, Burlov, Nikita, Campanelli, Michela, Capdepont, Maylis, Carvello, Michele, Chew, Hwee-Hoon, Christoforidis, Dimitri, Clark, David, Climent, Marta, Cologne, Kyle G, Contreras, Tomas, Croner, Roland, Daniels, Ian R, Dapri, Giovanni, Davies, Justin, Delrio, Paolo, Denost, Quentin, Deutsch, Michael, Dias, Andre, D'Hoore, André, Drozdov, Evgeniy, Duek, Daniel, Dunlop, Malcolm, Dziki, Adam, Edmundson, Aleksandra, Efetov, Sergey, El-Hussuna, Alaa, Elliot, Brodie, Emile, Sameh, Espin, Eloy, Evans, Martyn, Faes, Seraina, Faiz, Omar, Fleming, Fergal, Foppa, Caterina, Fowler, George, Frasson, Matteo, Figueiredo, Nuno, Forgan, Tim, Frizelle, Frank, Gadaev, Shamil, Gellona, Jose, Glyn, Tamara, Gong, Jianping, Goran, Barisic, Greenwood, Emma, Guren, Marianne G, Guillon, Stephanie, Gutlic, Ida, Hahnloser, Dieter, Hampel, Heather, Hanly, Ann, Hasegawa, Hirotoshi, Iversen, Lene Hjerrild, Hill, Andrew, Hill, James, Hoch, Jiri, Hoffmeister, Michael, Hompes, Roel, Hurtado, Luis, Iaquinandi, Fabiano, Imbrasaite, Ugne, Islam, Rumana, Jafari, Mehrenah Dorna, Kanemitsu, Yukihide, Karachun, Aleksei, Karimuddin, Ahmer A, Keller, Deborah S, Kelly, Justin, and Kennelly, Rory

Subjects
REACCT Collaborative
Abstract

ImportanceThe incidence of early-onset colorectal cancer (younger than 50 years) is rising globally, the reasons for which are unclear. It appears to represent a unique disease process with different clinical, pathological, and molecular characteristics compared with late-onset colorectal cancer. Data on oncological outcomes are limited, and sensitivity to conventional neoadjuvant and adjuvant therapy regimens appear to be unknown. The purpose of this review is to summarize the available literature on early-onset colorectal cancer.ObservationsWithin the next decade, it is estimated that 1 in 10 colon cancers and 1 in 4 rectal cancers will be diagnosed in adults younger than 50 years. Potential risk factors include a Westernized diet, obesity, antibiotic usage, and alterations in the gut microbiome. Although genetic predisposition plays a role, most cases are sporadic. The full spectrum of germline and somatic sequence variations implicated remains unknown. Younger patients typically present with descending colonic or rectal cancer, advanced disease stage, and unfavorable histopathological features. Despite being more likely to receive neoadjuvant and adjuvant therapy, patients with early-onset disease demonstrate comparable oncological outcomes with their older counterparts.Conclusions and relevanceThe clinicopathological features, underlying molecular profiles, and drivers of early-onset colorectal cancer differ from those of late-onset disease. Standardized, age-specific preventive, screening, diagnostic, and therapeutic strategies are required to optimize outcomes.

Published
2021

11. MRI restaging of rectal cancer: The RAC (Response–Anal canal–CRM) analysis joint consensus guidelines of the GRERCAR and GRECCAR groups

Author

Nougaret, Stephanie, Rousset, Pascal, Lambregts, Doenja M.J., Maas, Monique, Gormly, Kirsten, Lucidarme, Oliver, Brunelle, Serge, Milot, Laurent, Arrivé, Lionel, Salut, Celine, Pilleul, Franck, Hordonneau, Constance, Baudin, Guillaume, Soyer, Philippe, Brun, Vanessa, Laurent, Valérie, Savoye-Collet, Celine, Petkovska, Iva, Gerard, Jean-Pierre, Cotte, Eddy, Rouanet, Philippe, Catalano, Onofrio, Denost, Quentin, Tan, Regina Beets, Frulio, Nora, and Hoeffel, Christine

Published
2023
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12. Stoma-free Survival After Rectal Cancer Resection With Anastomotic Leakage: Development and Validation of a Prediction Model in a Large International Cohort

Author

Greijdanus, Nynke G., Wienholts, Kiedo, Ubels, Sander, Talboom, Kevin, Hannink, Gerjon, Wolthuis, Albert, de Lacy, Francisco B., Lefevre, Jérémie H., Solomon, Michael, Frasson, Matteo, Rotholtz, Nicolas, Denost, Quentin, Perez, Rodrigo O., Konishi, Tsuyoshi, Panis, Yves, Rutegård, Martin, Hompes, Roel, Rosman, Camiel, van Workum, Frans, Tanis, Pieter J., de Wilt, Johannes H.W., Bremers, Andreas J.A., Ferenschild, Floris T., de Vriendt, Stefanie, D’Hoore, André, Bislenghi, Gabriele, Farguell, Jordi, Lacy, Antonio M., Atienza, Paula González, van Kessel, Charlotte S., Parc, Yann, Voron, Thibault, Collard, Maxime K., Muriel, Jorge Sancho, Cholewa, Hannia, Mattioni, Laura A., Frontali, Alice, Polle, Sebastiaan W., Polat, Fatih, Obihara, Ndidi J., Vailati, Bruna B., Kusters, Miranda, Tuynmann, Jurriaan B., Hazen, Sanne J.A., Grüter, Alexander A.J., Amano, Takahiro, Fujiwara, Hajime, Salomon, Mario, Ruiz, Hernán, Gonzalez, Ricardo, Estefanía, Diego, Avellaneda, Nicolas, Carrie, Augusto, Santillan, Mateo, Pantoja Pachajoa, Diana A., Parodi, Matias, Gielis, Manuel, Binder, Alf-Dorian, Gürtler, Thomas, Riedl, Peter, Badiani, Sarit, Berney, Christophe, Morgan, Matthew, Hollington, Paul, da Silva, Nigel, Nair, Gavin, Ho, Yiu M., Lamparelli, Michael, Kapadia, Raj, Kroon, Hidde M., Dudi-Venkata, Nagendra N., Liu, Jianliang, Sammour, Tarik, Flamey, Nicolas, Pattyn, Paul, Chaoui, Ahmed, Vansteenbrugge, Louis, van den Broek, Nathalie E.J., Vanclooster, Patrick, de Gheldere, Charles, Pletinckx, Pieter, Defoort, Barbara, Dewulf, Maxime, Slavchev, Mihail, Belev, Nikolay, Atanasov, Boyko, Krastev, Panche, Sokolov, Manol, Maslyankov, Svilen, Gribnev, Petar, Pavlov, Vasil, Ivanov, Tsvetomir, Karamanliev, Martin, Filipov, Emil, Tonchev, Pencho, Aigner, Felix, Mitteregger, Martin, Allmer, Caterina, Seitinger, Gerald, Colucci, Nicola, Buchs, Nicolas, Ris, Frédéric, Toso, Christian, Gialamas, Eleftherios, Vuagniaux, Aurélie, Chautems, Roland, Sauvain, Marc-Olivier, Daester, Silvio, von Flüe, Markus, Guenin, Marc-Olivier, Taha-Mehlitz, Stephanie, Hess, Gabriel F., Martínek, Lubomír, Skrovina, Matej, Machackova, Maria, Benčurik, Vladimir, Uluk, Deniz, Pratschke, Johann, Dittrich, Luca S., Guel-Klein, Safak, Perez, Daniel, Grass, Julia-Kristin, Melling, Nathaniel, Mueller, Simone, Iversen, Lene H., Eriksen, Jacob D., Baatrup, Gunnar, Al-Najami, Issam, Bjørsum-Meyer, Thomas, Teras, Jüri, Teras, Roland M., Monib, Fatma A., Abu Elnga Ahmed, Nagm Eldin, Alkady, Eithar, Ali, Ahmed K., Khedr, Gehan Abd Elatti, Abdelaal, Ahmed Samir, Bassyouni Ashoush, Fouad M., Ewedah, Moataz, Elshennawy, Eslam M., Hussein, Mohamed, Fernández-Martínez, Daniel, García-Flórez, Luis J., Fernández-Hevia, María, Suárez-Sánchez, Aida, del Hoyo Aretxabala, Izaskun, Docampo, Iria Losada, Zabala, Jesús Gómez, Tejedor, Patricia, Morales Bernaldo de Quirós, Javier T., Quiroga, Ignacio Bodega, Navarro-Sánchez, Antonio, Darias, Iván Soto, Fernández, Cristina López, de La Cruz Cuadrado, Cristina, Sánchez-Guillén, Luis, López-Rodríguez-Arias, Francisco, Soler-Silva, Álvaro, Arroyo, Antonio, Bernal-Sprekelsen, Juan C., Gómez-Abril, Segundo Á., Gonzálvez, Paula, Torres, María T., Sánchez, Teresa Rubio, Antona, Francisco Blanco, Sánchez Lara, Juan E., Alcázar Montero, José A., Fernández-Martínez, Daniel, García-Flórez, Luis J., Fernández-Hevia, María, Suárez-Sánchez, Aida, Colás-Ruiz, Enrique, Tasende-Presedo, Marta M., Fernández-Hurtado, Ignacio, Cifuentes-Ródenas, José A., Suárez, Marta Castro, Losada, Manuel, Hernández, Miguel, Alonso, Alfredo, Diéguez, Beatriz, Serralta, Daniel, Medina Quintana, Rita E., Gil Lopez, Jose M., Pinto, Francisca Lima, Nieto-Moreno, Elena, Bonito, Alba Correa, Santacruz, Carlos Cerdán, Marcos, Elena Bermejo, Septiem, Javier García, Calero-Lillo, Aránzazu, Alanez-Saavedra, Javier, Muñoz-Collado, Salvador, López-Lara, Manuel, Martínez, María Labalde, Herrero, Eduardo Ferrero, Borda, Francisco Javier García, Villar, Óscar García, Escartín, Jorge, Blas, Juan L., Ferrer, Rocío, Egea, Jorge García, Rodríguez-Infante, Antonio, Mínguez-Ruiz, Germán, Carreño-Villarreal, Guillermo, Pire-Abaitua, Gerardo, Dziakova, Jana, Rodríguez, Carlos Sáez-Cazallas, Pizarro Aranda, María J., Muguerza Huguet, José M., Borda-Arrizabalaga, Nerea, Enriquez-Navascués, José M., Echaniz, Garazi Elorza, Ansorena, Yolanda Saralegui, Estaire-Gómez, Mercedes, Martínez-Pinedo, Carlos, Barbero-Valenzuela, Alejandro, Ruíz-García, Pablo, Kraft, Miquel, Gómez-Jurado, María J., Pellino, Gianluca, Espín-Basany, Eloy, Cotte, Eddy, Panel, Nathalie, Goutard, Claire-Angéline, deÁngelis, Nicola, Lauka, Lelde, Shaikh, Shafaque, Osborne, Laura, Ramsay, George, Nichita, Vladimir-Ion, Bhandari, Santosh, Sarmah, Panchali, Bethune, Rob M., Pringle, Heather C.M., Massey, Lisa, Fowler, George E., Hamid, Hytham K.S., de Simone, Belinda D., Kynaston, James, Bradley, Nicholas, Stienstra, Roxane M., Gurjar, Shashank, Mukherjee, Tanmoy, Chandio, Ashfaq, Ahmed, Safia, Singh, Baljit, Runau, Francois, Chaudhri, Sanjay, Siaw, Oliver, Sarveswaran, Janahan, Miu, Victor, Ashmore, Daniel, Darwich, Haitham, Singh-Ranger, Deepak, Singh, Nirbhaibir, Shaban, Mohamed, Gareb, Fahed, Petropolou, Thalia, Polydorou, Adreas, Dattani, Mit, Afzal, Asma, Bavikatte, Akshay, Sebastian, Boby, Ward, Nicholas, Mishra, Amitabh, Manatakis, Dimitrios, Agalianos, Christos, Tasis, Nikolaos, Antonopoulou, Maria-Ioanna, Karavokyros, Ioannis, Charalabopoulos, Alexandros, Schizas, Dimitrios, Baili, Efstratia, Syllaios, Athanasios, Karydakis, Lysandros, Vailas, Michail, Balalis, Dimitrios, Korkolis, Dimitrios, Plastiras, Aris, Rompou, Aliki, Xenaki, Sofia, Xynos, Evangelos, Chrysos, Emmanuel, Venianaki, Maria, Christodoulidis, Grigorios, Perivoliotis, Konstantinos, Tzovaras, George, Baloyiannis, Ioannis, Ho, Man-Fung, Ng, Simon Siu-man, Mak, Tony Wing-chung, Futaba, Kaori, Šantak, Goran, Šimleša, Damir, osić, Jurica, Zukanović, Goran, Kelly, Michael E., Larkin, John O., McCormick, Paul H., Mehigan, Brian J., Connelly, Tara M., Neary, Peter, Ryan, Jessica, McCullough, Peter, Al-Juaifari, Maytham A., Hammoodi, Hayder, Abbood, Ali Hashim, Calabrò, Marcello, Muratore, Andrea, Terra, Antonio La, Farnesi, Francesca, Feo, Carlo V., Fabbri, Nicolò, Pesce, Antonio, Fazzin, Marta, Roscio, Francesco, Clerici, Federico, Lucchi, Andrea, Vittori, Laura, Agostinelli, Laura, Ripoli, Maria Cristina, Sambucci, Daniele, Porta, Andrea, Sinibaldi, Giovanni, Crescentini, Giacomo, larcinese, Antonella, Picone, Emanuele, Persiani, Roberto, Biondi, Alberto, Pezzuto, Roberto, Lorenzon, Laura, Rizzo, Gianluca, Coco, Claudio, D’Agostino, Luca, Spinelli, Antonino, Sacchi, Matteo M., Carvello, Michele, Foppa, Caterina, Spinelli, Antonino, Sacchi, Matteo M., Carvello, Michele, Foppa, Caterina, Maroli, Annalisa, Palini, Gian M., Garulli, Gianluca, Zanini, Nicola, Delrio, Paolo, Rega, Daniela, Carbone, Fabio, Aversano, Alessia, Pirozzolo, Giovanni, Recordare, Alfonso, DʼAlimonte, Lucrezia, Vignotto, Chiara, Corbellini, Carlo, Sampietro, Gianluca M., Lorusso, Leonardo, Manzo, Carlo A., Ghignone, Federico, Ugolini, Giampaolo, Montroni, Isacco, Pasini, Franceso, Pasini, Francesco, Ballabio, Michele, Bisagni, Pietro, Armao, Francesca T., Longhi, Marco, Ghazouani, Omar, Galleano, Raffaele, Tamini, Nicolò, Oldani, Massimo, Nespoli, Luca, Picciariello, Arcangelo, Altomare, Donato F., Tomasicchio, Giovanni, Lantone, Giuliano, Catena, Fausto, Giuffrida, Mario, Annicchiarico, Alfredo, Perrone, Gennaro, Grossi, Ugo, Santoro, Giulio A., Zanus, Giacomo, Iacomino, Alessandro, Novello, Simone, Passuello, Nicola, Zucchella, Martino, Puca, Lucia, deGiuli, Maurizio, Reddavid, Rossella, Scabini, Stefano, Aprile, Alessandra, Soriero, Domenico, Fioravanti, Emanuela, Rottoli, Matteo, Romano, Angela, Tanzanu, Marta, Belvedere, Angela, Mariani, Nicolò M., Ceretti, Andrea P., Opocher, Enrico, Gallo, Gaetano, Sammarco, Giuseppe, de Paola, Gilda, Pucciarelli, Salvatore, Marchegiani, Francesco, Spolverato, Gaya, Buzzi, Gianluca, Di Saverio, Salomone, Meroni, Paola, Parise, Cristiano, Bottazzoli, Elisa I., Lapolla, Pierfrancesco, Brachini, Gioia, Cirillo, Bruno, Mingoli, Andrea, Sica, Giuseppe, Siragusa, Leandro, Bellato, Vittoria, Cerbo, Daniele, de Pasqual, Carlo A., de Manzoni, Giovanni, di Cosmo, Maria A., Alrayes, Bourhan M.H., Qandeel, Mahmoud W. M., Hani, Mohammad Bani, Rabadi, Alexander, el Muhtaseb, Mohammad S., Abdeen, Basel, Karmi, Fahed, Žilinskas, Justas, Latkauskas, Tadas, Tamelis, Algimantas, Pikūnienė, Ingrida, Šlenfuktas, Vygintas, Poskus, Tomas, Kryzauskas, Marius, Jakubauskas, Matas, Mikalauskas, Saulius, Jakubauskiene, Lina, Hassan, Soha Y., Altrabulsi, Amani, Abdulwahed, Eman, Ghmagh, Reem, Deeknah, Abdulqudus, Alshareea, Entisar, Elhadi, Muhammed, Abujamra, Saleh, Msherghi, Ahmed A., Tababa, Osama W.E., Majbar, Mohammed A., Souadka, Amine, Benkabbou, Amine, Mohsine, Raouf, Echiguer, Sabrillah, Moctezuma-Velázquez, Paulina, Salgado-Nesme, Noel, Vergara-Fernández, Omar, Sainz-Hernández, Juan C., Alvarez-Bautista, Francisco E., Zakaria, Andee D., Zakaria, Zaidi, Wong, Michael P.K., Ismail, Razif, Ibrahim, Aini F., Abdullah, Nik A.N., Julaihi, Rokayah, Bhat, Sameer, OʼGrady, Greg, Bissett, Ian, Lamme, Bas, Musters, Gijsbert D., Dinaux, Anne M., Grotenhuis, Brechtje A., Steller Arend G.J. Aalbers, Ernst J., Leeuwenburgh, Marjolein M., Rutten, Harm J.T., Burger, Jacobus W.A., Bloemen, Johanne G., Ketelaers, Stijn H.J., Waqar, Usama, Chawla, Tabish, Rauf, Hareem, Rani, Pallavi, Talsma, Aaldert K., Scheurink, Lieke, van Praagh, Jasper B., Segelman, Josefin, Nygren, Jonas, Anderin, Kajsa, Tiefenthal, Marit, de Andrés, Beatriz, Beltrán de Heredia, Juan P., Vázquez, Andrea, Gómez, Tania, Golshani, Parisa, Kader, Rawaz, Mohamed, Abudi, Westerterp, Marinke, Marinelli, Andreas, Niemer, Quirine, Doornebosch, Pascal G., Shapiro, Joël, Vermaas, Maarten, de Graaf, Eelco J.R., van Westreenen, Hendrik L., Zwakman, Marije, van Dalsen, Annette D., Vles, Wouter J., Nonner, Joost, Toorenvliet, Boudewijn R., Janssen, Paul T.J., Verdaasdonk, Emiel G.G., Amelung, Femke J., Peeters Renu R. Bahadoer, Koen C.M.J., Holman, Fabian A., Heemskerk, Jeroen, Vosbeek, Noortje, Leijtens, Jeroen W.A., Taverne, Sophie B.M., Heijnen, Bob H.M., El-Massoudi, Youssef, de Groot-van Veen, Irene, Hoff, Christiaan, Jou-Valencia, Daniela, Consten, Esther C.J., Burghgraef, Thijs A., Geitenbeek, Ritch, Hulshof, Lorenzo G.W.L., Slooter, Gerrit D., Reudink, Muriël, Bouvy, Nicole D., Wildeboer, Aurelia C. L., Verstappen, Sonja, Pennings, Alexander J., van den Hengel, Berber, Wijma, Allard G., de Haan, Jael, de Nes, Lindsey C.F., Heesink, Vera, Karsten, Tom, Heidsma, Charlotte M., Koemans, Willem J., Dekker, Jan-Willem T., van der Zijden, Charlène J., Roos, Daphne, Demirkiran, Ahmet, van der Burg, Sjirk, Oosterling, Steven J., Hoogteijling, Tijs J., Wiering, Bastiaan, Smeeing, Diederik P.J., Havenga, Klaas, Lutfi, Hamid, Consten, Esther C.J., Tsimogiannis, Konstantinos, Sköldberg, Filip, Folkesson, Joakim, den Boer, Frank, van Schaik, Ted G., van Gerven, Pieter, Sietses, Colin, Hol, Jeroen C., Boerma, Evert-Jan G., Creemers, Davy M.J., Schultz, Johannes K., Frivold, Tone, Riis, Rolf, Gregussen, Hilde, Busund, Sondre, Sjo, Ole H., Gaard, Maria, Krohn, Nina, Ersryd, Amanda L., Leung, Edmund, Waqar, Usama, Chawla, Tabish, Rauf, Hareem, Rani, Pallavi, Sultan, Hytham, Hajjaj, Baraa Nabil, Alhisi, Ahmed Jehad, Khader, Ahmed A.E., Mendes, Ana Filipa Dias, Semião, Miguel, Faria, Luis Queiroz, Azevedo, Constança, da Costa Devesa, Helena M., Martins, Sónia Fortuna, Rodrigues Jarimba, Aldo M., Ribeiro Marques, Sónia M., Ferreira, Rita Marques, Oliveira, António, Ferreira, Cátia, Pereira, Ricardo, Surlin, Valeriu M., Graure, Giorgiana M., Ramboiu, Stefan Patrascu Sandu D., Negoi, Ionut, Ciubotaru, Cezar, Stoica, Bogdan, Tanase, Ioan, Stoica, Bogdan, Ciubotaru, Cezar, Negoita, Valentina M., Florea, Sabrina, Macau, Florin, Vasile, Mihai, Stefanescu, Victor, Dimofte, Gabriel-Mihail, Luncă, Sorinel, Roată, Cristian-Ene, Mu[Latin Small Letter s with comma below]ină, Ana-Maria, Garmanova, Tatiana, Agapov, Mikhail N., Markaryan, Daniil G., Eduard, Galliamov, Yanishev, Alexey, Abelevich, Alexander, Bazaev, Andrey, Rodimov, Sergey V., Filimonov, Victor B., Melnikov, Andrey A., Suchkov, Igor A., Drozdov, EvgeniyS., Kostromitskiy, Dmitriy N., Sjöström, Olle, Matthiessen, Peter, Baban, Bayar, Gadan, Soran, Jadid, Kaveh Dehlaghi, Staffan, Maria, Park, Jennifer M., Rydbeck, Daniel, Lydrup, Marie-Louise, Buchwald, Pamela, Jutesten, Henrik, Darlin, Lotten, Lindqvist, Ebba, Nilsson, Karl, Larsson, Per-Anders, Jangmalm, Staffan, Košir, Jurij A., Tomažič, Aleš, Grosek, Jan, Božič, Tajda Košir, Zazo, Aya, Zazo, Rama, Fares, Hala, Ayoub, Kusay, Niazi, Ammar, Mansour, Ali, Abbas, Ayman, Tantoura, Mohammad, Hamdan, Alaa, Hassan, Naya, Hasan, Bassam, Saad, Ahmad, Sebai, Amine, Haddad, Anis, Maghrebi, Houcine, Kacem, Montasser, Yalkın, Ömer, Samsa, Mehmet Veysi, Atak, İbrahim, Balci, Bengi, Haberal, Elifcan, Dogan, Lütfi, Gecim, Ibrahim E., Akyol, Cihangir, Koc, Mehmet A., Sivrikoz, Emre, Piyadeoğlu, Deniz, Larkin, John O., avanagh, Dara O., Sökmen, Selman, Bişgin, Tayfun, Günenç, Erşan, Güzel, Melek, Leventoğlu, Sezai, Yüksel, Osman, Kozan, Ramazan, Göbüt, Hüseyin, Cengiz, Fevzi, Erdinc, Kemal, Acar, Nihan Coşgun, Kamer, Erdinc, Özgür, İlker, Aydın, Oguzhan, Keskin, Metin, Bulut, Mehmet Türker, Kulle, Cemil B., Kara, Yasin, Sıbıç, Osman, Özata, İbrahim H., Buğra, Dursun, Balık, Emre, Kulle, Cemil B., Çakır, Murat, Alhardan, Anas, Colak, Elif, CiftciEngin Aybar, Ahmet B., Sari, Ahmet Can, Atici, Semra Demirli, Kaya, Tayfun, Dursun, Ayberk, Calik, Bulent, Özkan, Ömer Faruk, Ülgür, Hanife Şeyda, Düzgün, Özgül, Monson, John, George, Sarah, Woods, Kayla, Al-Eryani, Fatima, Albakry, Rudaina, Coetzee, Emile, Boutall, Adam, Herman, Ayesiga, Warden, Claire, Mugla, Naser, Forgan, Tim, Mia, Imraan, and Lambrechts, Anton

Published
2023
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13. Is Delaying a Coloanal Anastomosis the Ideal Solution for Rectal Surgery?: Analysis of a Multicentric Cohort of 564 Patients From the GRECCAR

Author

Collard, Maxime K., Rullier, Eric, Tuech, Jean-Jacques, Sabbagh, Charles, Souadka, Amine, Loriau, Jérome, Faucheron, Jean-Luc, Benoist, Stéphane, Dubois, Anne, Dumont, Frédéric, Germain, Adeline, Manceau, Gilles, Marchal, Frédéric, Sourrouille, Isabelle, Lakkis, Zaher, Lelong, Bernard, Derieux, Simon, Piessen, Guillaume, Laforest, Anaïs, Venara, Aurélien, Prudhomme, Michel, Brigand, Cécile, Duchalais, Emilie, Ouaissi, Mehdi, Lebreton, Gil, Rouanet, Philippe, Mège, Diane, Pautrat, Karine, Reynolds, Ian S., Pocard, Marc, Parc, Yann, Denost, Quentin, and Lefevre, Jérémie H.

Published
2023
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18. TAilored SToma policY after TME for rectal cancer: The TASTY approach.

Author

Boissieras, Lara, Harji, Deena, Celerier, Bertrand, Rullier, Eric, and Denost, Quentin

Subjects
DISEASE risk factors, RECTAL cancer, RECEIVER operating characteristic curves, SURGICAL stomas, REFERENCE values, RECTAL surgery
Abstract

Aim: Diverting stomas are routinely used in restorative surgery following total mesorectal exicision (TME) for rectal cancer to mitigate the clinical risks of anastomotic leakage (AL). However, routine diverting stomas are associated with their own complication profile and may not be required in all patients. A tailored approach based on personalized risk of AL and selective use of diverting stoma may be more appropriate. The aim of the TAilored SToma policY (TASTY) project was to design and pilot a standardized, tailored approach to diverting stoma in low rectal cancer. Method: A mixed‐methods approach was employed. Phase I externally validated the anastomotic failure observed risk score (AFORS). We compared the observed rate of AL in our cohort to the theoretical, predicted risk of the AFORS score. To identify the subset of patients who would benefit from early closure of the diverting stoma using C‐reactive protein (CRP) we calculated the Youden index. Phase II designed the TASTY approach based on the results of Phase I. This was evaluated within a second prospective cohort study in patients undergoing TME for rectal cancer between April 2018 and April 2020. Results: A total of 80 patients undergoing TME surgery for rectal cancer between 2016 and 2018 participated in the external validation of the AFORS score. The overall observed AL rate in this cohort of patients was 17.5% (n = 14). There was a positive correlation between the predicted and observed rates of AL using the AFORS score. Using ROC curves, we calculated a CRP cutoff value of 115 mg/L on postoperative day 2 for AL with a sensitivity of 86% and a negative predictive value of 96%. The TASTY approach was designed to allocate patients with a low risk AFORS score to primary anastomosis with no diverting stoma and high risk AFORS score patients to a diverting stoma, with early closure at 8–14 days, if CRP values and postoperative CT were satisfactory. The TASTY approach was piloted in 122 patients, 48 (39%) were identified as low risk (AFORS score 0–1) and 74 (61%) were considered as high risk (AFORS score 2–6). The AL rate was 10% in the low‐risk cohort of patient compared to 23% in the high‐risk cohort of patients, p = 0.078 The grade of Clavien‐Dindo morbidity was equivalent. The incidence of major LARS was lowest in the no stoma cohort at 3 months (p = 0.014). Conclusion: This study demonstrates the feasibility and safety of employing a selective approach to diverting stoma in patients with a low anastomosis following TME surgery for rectal cancer. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Multicentre cohort study evaluating clinical, oncological and functional outcomes following robotic rectal cancer surgery—the EUREKA collaborative: trial protocol

Author

Heelkunde Opleiding, MS CGO, Cancer, Fleming, Christina A., Duhoky, Rauand, Geitenbeek, Ritchie T.J., Moussion, Aurore, Bouazza, Nabila, Khan, Jim, Cotte, Eddy, Dubois, Anne, Rullier, Eric, Hompes, R., Denost, Quentin, Rouanet, Philippe, Consten, Esther C.J., Burghgraef, T. A., van Grevenstein, W. M.U., EUREKA collaborative, Heelkunde Opleiding, MS CGO, Cancer, Fleming, Christina A., Duhoky, Rauand, Geitenbeek, Ritchie T.J., Moussion, Aurore, Bouazza, Nabila, Khan, Jim, Cotte, Eddy, Dubois, Anne, Rullier, Eric, Hompes, R., Denost, Quentin, Rouanet, Philippe, Consten, Esther C.J., Burghgraef, T. A., van Grevenstein, W. M.U., and EUREKA collaborative

Published
2024

28. Organ preservation with chemoradiotherapy plus local excision for rectal cancer: 5-year results of the GRECCAR 2 randomised trial

Author

Rullier, Eric, Vendrely, Véronique, Asselineau, Julien, Rouanet, Philippe, Tuech, Jean-Jacques, Valverde, Alain, de Chaisemartin, Cecile, Rivoire, Michel, Trilling, Bertrand, Jafari, Mehrdad, Portier, Guillaume, Meunier, Bernard, Sieleznieff, Igor, Bertrand, Martin, Marchal, Frédéric, Dubois, Anne, Pocard, Marc, Rullier, Anne, Smith, Denis, Frulio, Nora, Frison, Eric, and Denost, Quentin

Published
2020
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35. Response to the Comment on “Local Recurrence After TaTME for Rectal Cancer”

Author

Roodbeen, Sapho Xenia, Spinelli, Antonino, Bemelman, Willem, Di Candido, Francesca, Cardepont, Maylis, Denost, Quentin, D’Hoore, Andre, van Dieren, Susan, Houben, Bert, Knol, Joep J., Martín-Pérez, Beatriz, Rullier, Eric, Sands, Dana, Setton, Ilana, Van de Steen, Katrien, Tanis, Pieter J., Wexner, Steven D., Wolthuis, Albert M., and Hompes, Roel

Published
2021
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36. Multicentre cohort study evaluating clinical, oncological and functional outcomes following robotic rectal cancer surgery—the EUREKA collaborative: trial protocol.

Author

Fleming, Christina A, Duhoky, Rauand, Geitenbeek, Ritchie T J, Moussion, Aurore, Bouazza, Nabila, Khan, Jim, Cotte, Eddy, Dubois, Anne, Rullier, Eric, Hompes, Roel, Denost, Quentin, Rouanet, Philippe, Consten, Esther C J, and collaborative, EUREKA

Subjects
RECTAL surgery, RECTAL cancer, ONCOLOGIC surgery, FUNCTIONAL status
Abstract

This article discusses a multicenter cohort study that examines the outcomes of robotic rectal cancer surgery. The study compares different surgical techniques and evaluates the safety and effectiveness of robotic surgery for rectal cancer. The article provides information on the study's design, eligibility criteria, surgical interventions, and data management. The study aims to collect international outcome data on complex high-risk cases and will include patient-reported outcome measures. The results of the study will be shared through scientific meetings and peer-reviewed journals. [Extracted from the article]

Published
2024
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38. Low‐impact laparoscopy in colorectal resection—A multicentric randomised trial comparing low‐pressure pneumoperitoneum plus microsurgery versus low‐pressure pneumoperitoneum alone: The PAROS II trial

Author

Marichez, Arthur, primary, Eude, Audrey, additional, Martenot, Mathieu, additional, Celerier, Bertrand, additional, Capdepont, Maylis, additional, Rullier, Eric, additional, Denost, Quentin, additional, and Fernandez, Benjamin, additional

Published
2023
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40. Surgical management of obstructive right-sided colon cancer at a national level results of a multicenter study of the French Surgical Association in 776 patients

Author

Berger, Anne, Ouaissi, Mehdi, Codjia, Tatiana, Dazza, Marie, Gagnat, Guillaume, Hamel, Servane, Mallet, Laure, Martre, Paul, Philouze, Guillaume, Roussel, Edouard, Tortajada, Pauline, Dumaine, Anne Stéphanie, Heyd, Bruno, Lakkis, Zaher, Paquette, Brice, de' Angelis, Nicola, Esposito, Francesco, Lizzi, Vincenzo, Michot, Nicolas, Denost, Quentin, Tresallet, Christophe, Tetard, Oriana, Sabbagh, Charles, Rivier, Pauline, Fayssal, Elie, Collard, Maxime, Moszkowicz, David, Peschaud, Frederique, Etienne, Jean Charles, loge, Ludovic, Beyer-Berjot, Laura, Bege, Thierry, Corte, Hélène, Bonnet, Julien, D'Annunzio, Elsa, Humeau, Marine, Issard, Julien, Munoz, Nicolas, Abba, Julio, Jafar, Yaqoub, Lacaze, Laurence, Sage, Pierre Yves, Susoko, Lilija, Trilling, Bertrand, Arvieux, Catherine, Mauvais, François, Severino, Béatrice Ulloa, Pitel, Sophie, Vauchaussade de Chaumont, Arthus, Badic, Bogdan, Blanc, Benjamin, Bert, Marine, Rat, Paul, Ortega-Deballon, Pablo, Chau, Amélie, Dejeante, Clémentine, Mariette, Christophe, Piessen, Guillaume, Grégoire, Emilie, Alfarai, Abdallah, Lefèvre, Jérémie, Cabau, Magali, David, Anaelle, Kadoche, Deborah, Dufour, Fanny, Goin, Géraldine, Goudard, Yvain, Pauleau, Ghislain, Sockeel, Philippe, De la Villeon, Bruno, Pautrat, Karine, Eveno, Clarisse, Brouquet, Antoine, Couchard, Anne Cécile, Balbo, Gregoire, Mabrut, Jean Yves, Bellinger, Justine, Bertrand, Martin, Aumont, Aurélie, Duchalais, Emilie, Messière Adrien Tranchart, Anne-Sophie, Cazauran, Jean-Baptiste, Pichot-Delahaye, Virginie, Dubuisson, Vincent, Maggiori, Leon, Boumediene, Bilem Djawad, Fuks, David, Kahn, Xavier, Huart, Eve, Catheline, Jean Marc, Lailler, Grégory, Baraket, Oussama, Baque, Patrick, Diaz de Cerio, Jean Marie, Bernard Maes, Philippe Mariol, Fernoux, Philippe, Guillem, Philippe, Chatelain, Eric, de Saint Roman, Charlotte, Fixot, Kévin, Mege, Diane, Manceau, Gilles, Bridoux, Valérie, Venara, Aurélien, Voron, Thibault, Brunetti, Francesco, Sielezneff, Igor, and Karoui, Mehdi

Published
2018
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41. Response to Comment on “Local Recurrence After TaTME for Rectal Cancer”

Author

Roodbeen, Sapho Xenia, Spinelli, Antonino, Bemelman, Willem, Di Candido, Francesca, Cardepont, Maylis, Denost, Quentin, D’Hoore, Andre, van Dieren, Susan, Houben, Bert, Knol, Joep J., Martín-Pérez, Beatriz, Rullier, Eric, Sands, Dana, Setton, Ilana, Van de Steen, Katrien, Tanis, Pieter J., Wexner, Steven D., Wolthuis, Albert M., and Hompes, Roel

Published
2020
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43. International standardization and optimization group for intersphincteric resection (ISOG‐ISR): modified Delphi consensus on anatomy, definition, indication, surgical technique, specimen description and functional outcome

Author

Piozzi, Guglielmo Niccolò, primary, Khobragade, Krunal, additional, Aliyev, Vusal, additional, Asoglu, Oktar, additional, Bianchi, Paolo Pietro, additional, Butiurca, Vlad‐Olimpiu, additional, Chen, William Tzu‐Liang, additional, Cheong, Ju Yong, additional, Choi, Gyu‐Seog, additional, Coratti, Andrea, additional, Denost, Quentin, additional, Fukunaga, Yosuke, additional, Gorgun, Emre, additional, Guerra, Francesco, additional, Ito, Masaaki, additional, Khan, Jim S., additional, Kim, Hye Jin, additional, Kim, Jin Cheon, additional, Kinugasa, Yusuke, additional, Konishi, Tsuyoshi, additional, Kuo, Li‐Jen, additional, Kuzu, Mehmet Ayhan, additional, Lefevre, Jeremie H., additional, Liang, Jin‐Tung, additional, Marks, John, additional, Molnar, Călin, additional, Panis, Yves, additional, Rouanet, Philippe, additional, Rullier, Eric, additional, Saklani, Avanish, additional, Spinelli, Antonino, additional, Tsarkov, Petr, additional, Tsukamoto, Shunsuke, additional, Weiser, Martin, additional, and Kim, Seon Hahn, additional

Published
2023
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44. Local Regrowth and the Risk of Distant Metastases Among Patients Undergoing Watch-and-Wait for Rectal Cancer: What Is the Best Control Group? Multicenter Retrospective Study

Author

São Julião, Guilherme Pagin, primary, Fernández, Laura M., additional, Vailati, Bruna Borba, additional, Habr-Gama, Angelita, additional, Azevedo, José M., additional, Santiago, Inês A., additional, Parés, Oriol, additional, Parvaiz, Amjad, additional, Vendrely, Véronique, additional, Rullier, Anne, additional, Rullier, Eric, additional, Denost, Quentin, additional, and Perez, Rodrigo Oliva, additional

Published
2023
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47. Organ preservation for rectal cancer (GRECCAR 2): a prospective, randomised, open-label, multicentre, phase 3 trial

Author

Rullier, Eric, Rouanet, Philippe, Tuech, Jean-Jacques, Valverde, Alain, Lelong, Bernard, Rivoire, Michel, Faucheron, Jean-Luc, Jafari, Mehrdad, Portier, Guillaume, Meunier, Bernard, Sileznieff, Igor, Prudhomme, Michel, Marchal, Frédéric, Pocard, Marc, Pezet, Denis, Rullier, Anne, Vendrely, Véronique, Denost, Quentin, Asselineau, Julien, and Doussau, Adélaïde

Published
2017
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49. Stoma-free survival after anastomotic leak following rectal cancer resection: worldwide cohort of 2470 patients.

Author

Greijdanus, Nynke G., Wienholts, Kiedo, Ubels, Sander, Talboom, Kevin, Hannink, Gerjon, Wolthuis, Albert, de Lacy, F. Borja, Lefevre, Jérémie H., Solomon, Michael, Frasson, Matteo, Rotholtz, Nicolas, Denost, Quentin, Perez, Rodrigo O., Konishi, Tsuyoshi, Panis, Yves, Rutegård, Martin, Hompes, Roel, Rosman, Camiel, van Workum, Frans, and Tanis, Pieter J.

Subjects
RECTAL cancer, ONCOLOGIC surgery, PROPENSITY score matching, ILEOSTOMY
Abstract

Background: The optimal treatment of anastomotic leak after rectal cancer resection is unclear. This worldwide cohort study aimed to provide an overview of four treatment strategies applied. Methods: Patients from 216 centres and 45 countries with anastomotic leak after rectal cancer resection between 2014 and 2018 were included. Treatment was categorized as salvage surgery, faecal diversion with passive or active (vacuum) drainage, and no primary/ secondary faecal diversion. The primary outcome was 1-year stoma-free survival. In addition, passive and active drainage were compared using propensity score matching (2 : 1). Results: Of 2470 evaluable patients, 388 (16.0 per cent) underwent salvage surgery, 1524 (62.0 per cent) passive drainage, 278 (11.0 per cent) active drainage, and 280 (11.0 per cent) had no faecal diversion. One-year stoma-free survival rates were 13.7, 48.3, 48.2, and 65.4 per cent respectively. Propensity score matching resulted in 556 patients with passive and 278 with active drainage. There was no statistically significant difference between these groups in 1-year stoma-free survival (OR 0.95, 95 per cent c.i. 0.66 to 1.33), with a risk difference of -1.1 (95 per cent c.i. -9.0 to 7.0) per cent. After active drainage, more patients required secondary salvage surgery (OR 2.32, 1.49 to 3.59), prolonged hospital admission (an additional 6 (95 per cent c.i. 2 to 10) days), and ICU admission (OR 1.41, 1.02 to 1.94). Mean duration of leak healing did not differ significantly (an additional 12 (-28 to 52) days). Conclusion: Primary salvage surgery or omission of faecal diversion likely correspond to the most severe and least severe leaks respectively. In patients with diverted leaks, stoma-free survival did not differ statistically between passive and active drainage, although the increased risk of secondary salvage surgery and ICU admission suggests residual confounding. [ABSTRACT FROM AUTHOR]

Published
2023
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