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292 results on '"Dennison, Jennifer B"'

3. CES2 sustains HNF4α expression to promote pancreatic adenocarcinoma progression through an epoxide hydrolase-dependent regulatory loop

Author

Chen, Yihui, Capello, Michela, Perez, Mayrim V Rios, Vykoukal, Jody V, Roife, David, Kang, Ya'an, Prakash, Laura R, Katayama, Hiroyuki, Irajizad, Ehsan, Fleury, Alia, Ferri-Borgogno, Sammy, Baluya, Dodge L, Dennison, Jennifer B, Do, Kim-Anh, Fiehn, Oliver, Maitra, Anirban, Wang, Huamin, Chiao, Paul J, Katz, Matthew HG, Fleming, Jason B, Hanash, Samir M, and Fahrmann, Johannes F

Subjects
Biochemistry and Cell Biology, Biological Sciences, Pancreatic Cancer, Cancer, Digestive Diseases, Rare Diseases, Biotechnology, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Adenocarcinoma, Animals, Carboxylesterase, Carcinoma, Pancreatic Ductal, Cell Line, Tumor, Epoxide Hydrolases, Humans, Mice, Pancreatic Neoplasms, PDAC, HNF4 alpha, CES2, Classical/progenitor subtype, Phospholipid catabolism, HNF4α, Physiology, Biochemistry and cell biology
Abstract

ObjectiveIntra-tumoral expression of the serine hydrolase carboxylesterase 2 (CES2) contributes to the activation of the pro-drug irinotecan in pancreatic ductal adenocarcinoma (PDAC). Given other potential roles of CES2, we assessed its regulation, downstream effects, and contribution to tumor development in PDAC.MethodsAssociation between the mRNA expression of CES2 in pancreatic tumors and overall survival was assessed using The Cancer Genome Atlas. Cell viability, clonogenic, and anchorage-independent growth assays as well as an orthotopic mouse model of PDAC were used to evaluate the biological relevance of CES2 in pancreatic cancer. CES2-driven metabolic changes were determined by untargeted and targeted metabolomic analyses.ResultsElevated tumoral CES2 mRNA expression was a statistically significant predictor of poor overall survival in PDAC patients. Knockdown of CES2 in PDAC cells reduced cell viability, clonogenic capacity, and anchorage-independent growth in vitro and attenuated tumor growth in an orthotopic mouse model of PDAC. Mechanistically, CES2 was found to promote the catabolism of phospholipids resulting in HNF4α activation through a soluble epoxide hydrolase (sEH)-dependent pathway. Targeting of CES2 via siRNA or small molecule inhibitors attenuated HNF4α protein expression and reduced gene expression of classical/progenitor markers and increased basal-like markers. Targeting of the CES2-sEH-HNF4α axis using small molecule inhibitors of CES2 or sEH reduced cell viability.ConclusionsWe establish a novel regulatory loop between CES2 and HNF4α to sustain the progenitor subtype and promote PDAC progression and highlight the potential utility of CES2 or sEH inhibitors for the treatment of PDAC as part of non-irinotecan-containing regimens.

Published
2022

4. Modulating a prebiotic food source influences inflammation and immune-regulating gut microbes and metabolites: insights from the BE GONE trial

Author

Zhang, Xiaotao, Irajizad, Ehsan, Hoffman, Kristi L., Fahrmann, Johannes F., Li, Fangyu, Seo, Yongwoo David, Browman, Gladys J., Dennison, Jennifer B., Vykoukal, Jody, Luna, Pamela N., Siu, Wesley, Wu, Ranran, Murage, Eunice, Ajami, Nadim J., McQuade, Jennifer L., Wargo, Jennifer A., Long, James P., Do, Kim-Anh, Lampe, Johanna W., Basen-Engquist, Karen M., Okhuysen, Pablo C., Kopetz, Scott, Hanash, Samir M., Petrosino, Joseph F., Scheet, Paul, and Daniel, Carrie R.

Published
2023
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5. A blood-based metabolomic signature predictive of risk for pancreatic cancer

Author

Irajizad, Ehsan, Kenney, Ana, Tang, Tiffany, Vykoukal, Jody, Wu, Ranran, Murage, Eunice, Dennison, Jennifer B., Sans, Marta, Long, James P., Loftus, Maureen, Chabot, John A., Kluger, Michael D., Kastrinos, Fay, Brais, Lauren, Babic, Ana, Jajoo, Kunal, Lee, Linda S., Clancy, Thomas E., Ng, Kimmie, Bullock, Andrea, Genkinger, Jeanine M., Maitra, Anirban, Do, Kim-Anh, Yu, Bin, Wolpin, Brian M., Hanash, Sam, and Fahrmann, Johannes F.

Published
2023
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6. A polyamine-centric, blood-based metabolite panel predictive of poor response to CAR-T cell therapy in large B cell lymphoma

Author

Fahrmann, Johannes F., Saini, Neeraj Y., Chia-Chi, Chang, Irajizad, Ehsan, Strati, Paolo, Nair, Ranjit, Fayad, Luis E., Ahmed, Sairah, Lee, Hun Ju, Iyer, Swaminathan, Steiner, Raphael, Vykoukal, Jody, Wu, Ranran, Dennison, Jennifer B., Nastoupil, Loretta, Jain, Preetesh, Wang, Michael, Green, Michael, Westin, Jason, Blumenberg, Viktoria, Davila, Marco, Champlin, Richard, Shpall, Elizabeth J., Kebriaei, Partow, Flowers, Christopher R., Jain, Michael, Jenq, Robert, Stein-Thoeringer, Christoph K., Subklewe, Marion, Neelapu, Sattva S., and Hanash, Sam

Published
2022
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7. Lead-Time Trajectory of CA19-9 as an Anchor Marker for Pancreatic Cancer Early Detection

Author

Fahrmann, Johannes F., Schmidt, C. Max, Mao, Xiangying, Irajizad, Ehsan, Loftus, Maureen, Zhang, Jinming, Patel, Nikul, Vykoukal, Jody, Dennison, Jennifer B., Long, James P., Do, Kim-Anh, Zhang, Jianjun, Chabot, John A., Kluger, Michael D., Kastrinos, Fay, Brais, Lauren, Babic, Ana, Jajoo, Kunal, Lee, Linda S., Clancy, Thomas E., Ng, Kimmie, Bullock, Andrea, Genkinger, Jeanine, Yip-Schneider, Michele T., Maitra, Anirban, Wolpin, Brian M., and Hanash, Samir

Published
2021
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9. Validation of a Blood-Based Protein Biomarker Panel for a Risk Assessment of Lethal Lung Cancer in the Physicians' Health Study.

Author

Song, Lulu, Irajizad, Ehsan, Rundle, Andrew, Sesso, Howard D., Gaziano, John Michael, Vykoukal, Jody V., Do, Kim-Anh, Dennison, Jennifer B., Ostrin, Edwin J., Fahrmann, Johannes F., Perera, Frederica, and Hanash, Samir

Subjects
RISK assessment, RECEIVER operating characteristic curves, RESEARCH funding, SMOKING, LOGISTIC regression analysis, TUMOR markers, DESCRIPTIVE statistics, LONGITUDINAL method, LUNG tumors, TUMOR antigens, CONFIDENCE intervals, DATA analysis software, SENSITIVITY & specificity (Statistics), DISEASE risk factors
Abstract

Simple Summary: Improvements in lung cancer risk assessment to inform on the need for screening may be achieved through the use of biomarkers. Here, we report the findings of a validation study of a panel of four circulating protein biomarkers for the risk prediction of lung cancer in a cohort of pre-diagnostic plasmas obtained from the Physician's Health Study (PHS). We demonstrate that the protein panel can identify individuals at high risk of lung cancer up to two years prior to clinical diagnosis. This study aimed to assess a four-marker protein panel (4MP)'s performance, including the precursor form of surfactant protein B, cancer antigen 125, carcinoembryonic antigen, and cytokeratin-19, for predicting lung cancer in a cohort enriched with never- and ever-smokers. Blinded pre-diagnostic plasma samples collected within 2 years prior to a lung cancer diagnosis from 25 cases and 100 sex-, age-, and smoking-matched controls were obtained from the Physicians' Health Study (PHS). The 4MP yielded AUC performance estimates of 0.76 (95% CI: 0.61–0.92) and 0.69 (95% CI: 0.56–0.82) for predicting lung cancer within one year and within two years of diagnosis, respectively. When stratifying into ever-smokers and never-smokers, the 4MP had respective AUCs of 0.77 (95% CI: 0.63–0.92) and 0.72 (95% CI: 0.17–1.00) for a 1-year risk of lung cancer. The AUCs of the 4MP for predicting metastatic lung cancer within one year and two years of the blood draw were 0.95 (95% CI: 0.87–1.00) and 0.78 (95% CI: 0.62–0.94), respectively. Our findings indicate that a blood-based biomarker panel may be useful in identifying ever- and never-smokers at high risk of a diagnosis of lung cancer within one-to-two years. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Contributions of the Microbiome-Derived Metabolome for Risk Assessment and Prognostication of Pancreatic Cancer

Author

León-Letelier, Ricardo A, primary, Dou, Rongzhang, additional, Vykoukal, Jody, additional, Yip-Schneider, Michele T, additional, Maitra, Anirban, additional, Irajizad, Ehsan, additional, Wu, Ranran, additional, Dennison, Jennifer B, additional, Do, Kim-An, additional, Zhang, Jianjun, additional, Schmidt, C Max, additional, Hanash, Samir, additional, and Fahrmann, Johannes F, additional

Published
2024
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11. Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer

Author

Ciriello, Giovanni, Gatza, Michael L, Beck, Andrew H, Wilkerson, Matthew D, Rhie, Suhn K, Pastore, Alessandro, Zhang, Hailei, McLellan, Michael, Yau, Christina, Kandoth, Cyriac, Bowlby, Reanne, Shen, Hui, Hayat, Sikander, Fieldhouse, Robert, Lester, Susan C, Tse, Gary MK, Factor, Rachel E, Collins, Laura C, Allison, Kimberly H, Chen, Yunn-Yi, Jensen, Kristin, Johnson, Nicole B, Oesterreich, Steffi, Mills, Gordon B, Cherniack, Andrew D, Robertson, Gordon, Benz, Christopher, Sander, Chris, Laird, Peter W, Hoadley, Katherine A, King, Tari A, Perou, Charles M, Akbani, Rehan, Auman, J Todd, Balasundaram, Miruna, Balu, Saianand, Barr, Thomas, Beck, Andrew, Benz, Stephen, Berrios, Mario, Beroukhim, Rameen, Bodenheimer, Tom, Boice, Lori, Bootwalla, Moiz S, Bowen, Jay, Brooks, Denise, Chin, Lynda, Cho, Juok, Chudamani, Sudha, Davidsen, Tanja, Demchok, John A, Dennison, Jennifer B, Ding, Li, Felau, Ina, Ferguson, Martin L, Frazer, Scott, Gabriel, Stacey B, Gao, JianJiong, Gastier-Foster, Julie M, Gehlenborg, Nils, Gerken, Mark, Getz, Gad, Gibson, William J, Hayes, D Neil, Heiman, David I, Holbrook, Andrea, Holt, Robert A, Hoyle, Alan P, Hu, Hai, Huang, Mei, Hutter, Carolyn M, Hwang, E Shelley, Jefferys, Stuart R, Jones, Steven JM, Ju, Zhenlin, Kim, Jaegil, Lai, Phillip H, Lawrence, Michael S, Leraas, Kristen M, Lichtenberg, Tara M, Lin, Pei, Ling, Shiyun, Liu, Jia, Liu, Wenbin, Lolla, Laxmi, Lu, Yiling, Ma, Yussanne, Maglinte, Dennis T, Mardis, Elaine, Marks, Jeffrey, Marra, Marco A, and McAllister, Cynthia

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Breast Cancer, Clinical Research, Genetics, Clinical Trials and Supportive Activities, Cancer, Antigens, CD, Breast Neoplasms, Cadherins, Carcinoma, Ductal, Breast, Carcinoma, Lobular, Female, Hepatocyte Nuclear Factor 3-alpha, Humans, Models, Molecular, Mutation, Oligonucleotide Array Sequence Analysis, Oncogene Protein v-akt, Transcriptome, TCGA Research Network, Biological Sciences, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

Invasive lobular carcinoma (ILC) is the second most prevalent histologic subtype of invasive breast cancer. Here, we comprehensively profiled 817 breast tumors, including 127 ILC, 490 ductal (IDC), and 88 mixed IDC/ILC. Besides E-cadherin loss, the best known ILC genetic hallmark, we identified mutations targeting PTEN, TBX3, and FOXA1 as ILC enriched features. PTEN loss associated with increased AKT phosphorylation, which was highest in ILC among all breast cancer subtypes. Spatially clustered FOXA1 mutations correlated with increased FOXA1 expression and activity. Conversely, GATA3 mutations and high expression characterized luminal A IDC, suggesting differential modulation of ER activity in ILC and IDC. Proliferation and immune-related signatures determined three ILC transcriptional subtypes associated with survival differences. Mixed IDC/ILC cases were molecularly classified as ILC-like and IDC-like revealing no true hybrid features. This multidimensional molecular atlas sheds new light on the genetic bases of ILC and provides potential clinical options.

Published
2015

12. Supplementary Table S4 from Exercise Training Reduces the Inflammatory Response and Promotes Intestinal Mucosa-Associated Immunity in Lynch Syndrome

Author

Deng, Nan, primary, Reyes-Uribe, Laura, primary, Fahrmann, Johannes F., primary, Thoman, Whittney S., primary, Munsell, Mark F., primary, Dennison, Jennifer B., primary, Murage, Eunice, primary, Wu, Ranran, primary, Hawk, Ernest T., primary, Thirumurthi, Selvi, primary, Lynch, Patrick M., primary, Dieli-Conwright, Christina M., primary, Lazar, Alexander J., primary, Jindal, Sonali, primary, Chu, Khoi, primary, Chelvanambi, Manoj, primary, Basen-Engquist, Karen, primary, Li, Yisheng, primary, Wargo, Jennifer A., primary, McAllister, Florencia, primary, Allison, James P., primary, Sharma, Padmanee, primary, Sinha, Krishna M., primary, Hanash, Samir, primary, Gilchrist, Susan C., primary, and Vilar, Eduardo, primary

Published
2023
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13. Supplementary Figure S2 from Exercise Training Reduces the Inflammatory Response and Promotes Intestinal Mucosa-Associated Immunity in Lynch Syndrome

Author

Deng, Nan, primary, Reyes-Uribe, Laura, primary, Fahrmann, Johannes F., primary, Thoman, Whittney S., primary, Munsell, Mark F., primary, Dennison, Jennifer B., primary, Murage, Eunice, primary, Wu, Ranran, primary, Hawk, Ernest T., primary, Thirumurthi, Selvi, primary, Lynch, Patrick M., primary, Dieli-Conwright, Christina M., primary, Lazar, Alexander J., primary, Jindal, Sonali, primary, Chu, Khoi, primary, Chelvanambi, Manoj, primary, Basen-Engquist, Karen, primary, Li, Yisheng, primary, Wargo, Jennifer A., primary, McAllister, Florencia, primary, Allison, James P., primary, Sharma, Padmanee, primary, Sinha, Krishna M., primary, Hanash, Samir, primary, Gilchrist, Susan C., primary, and Vilar, Eduardo, primary

Published
2023
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14. Data from Exercise Training Reduces the Inflammatory Response and Promotes Intestinal Mucosa-Associated Immunity in Lynch Syndrome

Author

Deng, Nan, primary, Reyes-Uribe, Laura, primary, Fahrmann, Johannes F., primary, Thoman, Whittney S., primary, Munsell, Mark F., primary, Dennison, Jennifer B., primary, Murage, Eunice, primary, Wu, Ranran, primary, Hawk, Ernest T., primary, Thirumurthi, Selvi, primary, Lynch, Patrick M., primary, Dieli-Conwright, Christina M., primary, Lazar, Alexander J., primary, Jindal, Sonali, primary, Chu, Khoi, primary, Chelvanambi, Manoj, primary, Basen-Engquist, Karen, primary, Li, Yisheng, primary, Wargo, Jennifer A., primary, McAllister, Florencia, primary, Allison, James P., primary, Sharma, Padmanee, primary, Sinha, Krishna M., primary, Hanash, Samir, primary, Gilchrist, Susan C., primary, and Vilar, Eduardo, primary

Published
2023
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15. Supplementary Materials and Methods 1 from Exercise Training Reduces the Inflammatory Response and Promotes Intestinal Mucosa-Associated Immunity in Lynch Syndrome

Author

Deng, Nan, primary, Reyes-Uribe, Laura, primary, Fahrmann, Johannes F., primary, Thoman, Whittney S., primary, Munsell, Mark F., primary, Dennison, Jennifer B., primary, Murage, Eunice, primary, Wu, Ranran, primary, Hawk, Ernest T., primary, Thirumurthi, Selvi, primary, Lynch, Patrick M., primary, Dieli-Conwright, Christina M., primary, Lazar, Alexander J., primary, Jindal, Sonali, primary, Chu, Khoi, primary, Chelvanambi, Manoj, primary, Basen-Engquist, Karen, primary, Li, Yisheng, primary, Wargo, Jennifer A., primary, McAllister, Florencia, primary, Allison, James P., primary, Sharma, Padmanee, primary, Sinha, Krishna M., primary, Hanash, Samir, primary, Gilchrist, Susan C., primary, and Vilar, Eduardo, primary

Published
2023
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17. Exercise Training Reduces the Inflammatory Response and Promotes Intestinal Mucosa-associated Immunity in Lynch Syndrome

Author

Deng, Nan, primary, Reyes-Uribe, Laura, additional, Fahrmann, Johannes F., additional, Thoman, Whittney S., additional, Munsell, Mark F., additional, Dennison, Jennifer B., additional, Murage, Eunice, additional, Wu, Ranran, additional, Hawk, Ernest T., additional, Thirumurthi, Selvi, additional, Lynch, Patrick M., additional, Dieli-Conwright, Christina M., additional, Lazar, Alexander J., additional, Jindal, Sonali, additional, Chu, Khoi, additional, Chelvanambi, Manoj, additional, Basen-Engquist, Karen, additional, Li, Yisheng, additional, Wargo, Jennifer A., additional, McAllister, Florencia, additional, Allison, James P., additional, Sharma, Padmanee, additional, Sinha, Krishna M., additional, Hanash, Samir, additional, Gilchrist, Susan C., additional, and Vilar, Eduardo, additional

Published
2023
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18. Integrated spatial transcriptomics and lipidomics of precursor lesions of pancreatic cancer identifies enrichment of long chain sulfatide biosynthesis as an early metabolic alteration

Author

Sans, Marta, primary, Chen, Yihui, additional, Thege, Fredrik I, additional, Dou, Rongzhang, additional, Min, Jimin, additional, Yip-Schneider, Michele, additional, Zhang, Jianjun, additional, Wu, Ranran, additional, Irajizad, Ehsan, additional, Makino, Yuki, additional, Rajapakshe, Kimal I, additional, Hurd, Mark W, additional, Leon, Ricardo A, additional, Vykoukal, Jody, additional, Dennison, Jennifer B, additional, Do, Kim-anh, additional, Wolff, Robert A, additional, Guerrero, Paola A, additional, Kim, Michael P, additional, Schmidt, C. Max, additional, Maitra, Anirban, additional, Hanash, Samir, additional, and Fahrmann, Johannes F, additional

Published
2023
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19. Caveolin-1-mediated sphingolipid oncometabolism underlies a metabolic vulnerability of prostate cancer

Author

Vykoukal, Jody, Fahrmann, Johannes F., Gregg, Justin R., Tang, Zhe, Basourakos, Spyridon, Irajizad, Ehsan, Park, Sanghee, Yang, Guang, Creighton, Chad J., Fleury, Alia, Mayo, Jeffrey, Paulucci-Holthauzen, Adriana, Dennison, Jennifer B., Murage, Eunice, Peterson, Christine B., Davis, John W., Kim, Jeri, Hanash, Samir, and Thompson, Timothy C.

Published
2020
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20. Blood-based Proteomic Signatures Associated With MENI-related Duodenopancreatic Neuroendocrine Tumor Progression.

Author

Fahrmann, Johannes F., Wasylishen, Amanda R., Pieterman, Carolina R. C., Irajizad, Ehsan, Vykoukal, Jody, Wu, Ranran, Dennison, Jennifer B., Peterson, Christine B., Hua Zhao, Kim-Anh Do, Halperin, Daniel M., Agarwal, Sunita K., Blau, Jenny E., Jha, Smita, Del Rivero, Jaydira, Nilubol, Naris, Walter, Mary F., Welch, James M., Weinstein, Lee S., and Vriens, Menno R.

Subjects
NEUROENDOCRINE tumors, MASS spectrometry, DISEASE progression
Abstract

Purpose: Patients with multiple endocrine neoplasia type 1 (MEN1) are predisposed to develop duodenopancreatic neuroendocrine tumors (dpNETs), and metastatic dpNET is the primary cause of disease-related mortality. Presently, there is a paucity of prognostic factors that can reliably identify patients with MEN1-related dpNETS who are at high risk of distant metastasis. In the current study, we aimed to establish novel circulating molecular protein signatures associated with disease progression. Experimental Design: Mass spectrometry-based proteomic profiling was conducted on plasmas procured through an international collaboration between MD Anderson Cancer Center, the National Institutes of Health, and the University Medical Center Utrecht from a cohort of 56 patients with MEN1 [14 with distant metastasis dpNETs (cases) and 42 with either indolent dpNETs or no dpNETs (controls)]. Findings were compared to proteomic profiles generated from serially collected plasmas from a mouse model of Men1-pancreatic neuroendocrine tumors (Men1fl/flPdx1-CreTg) and control mice (Men1fl/fl). Results: A total of 187 proteins were found to be elevated in MEN1 patients with distant metastasis compared to controls, including 9 proteins previously associated with pancreatic cancer and other neuronal proteins. Analyses of mouse plasmas revealed 196 proteins enriched for transcriptional targets of oncogenic MYCN, YAP1, POU5F1, and SMAD that were associated with disease progression in Men1fl/flPdx1-CreTg mice. Cross-species intersection revealed 19 proteins positively associated with disease progression in both human patients and in Men1fl/flPdx1-CreTg mice. Conclusions: Our integrated analyses identified novel circulating protein markers associated with disease progression in MEN1-related dpNET. [ABSTRACT FROM AUTHOR]

Published
2023
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21. Abstract 558: EGFR inhibition in lung adenocarcinoma upregulates cell surface expression of the placental antigen ALPP and enhances efficacy of ALPP-ADC therapy

Author

Chen, Yihui, primary, Hong, Monica, additional, Xu, Hanwen, additional, Vykoukal, Jody, additional, Park, Soyoung, additional, Cai, Yining, additional, León-Letelier, Ricardo A., additional, Hsiao, Fu Chung, additional, Dennison, jennifer B., additional, Ostrin, Edwin J., additional, Fahrmann, Johannes F., additional, Katayama, Hiroyuki, additional, and Hanash, Samir M., additional

Published
2023
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22. Abstract 6031: KYNU upregulation is a prominent feature of NRF2-activated cancers and is associated with tumor immunosuppression and poor prognosis

Author

Letelier, Ricardo A. Leon, primary, Sater, Ali H. Abdel, additional, Chen, Yihui, additional, Wu, Ranran, additional, Dennison, Jennifer B., additional, Park, Soyoung, additional, Irajizad, Ehsan, additional, Katayama, Hiroyuki, additional, Vykoukal, Jody, additional, Hanash, Samir, additional, Ostrin, Edwin J., additional, and Fahrmann, Johannes F., additional

Published
2023
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23. Supplementary Figure 2 from Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer

Author

Gross, Matt I., primary, Demo, Susan D., primary, Dennison, Jennifer B., primary, Chen, Lijing, primary, Chernov-Rogan, Tania, primary, Goyal, Bindu, primary, Janes, Julie R., primary, Laidig, Guy J., primary, Lewis, Evan R., primary, Li, Jim, primary, MacKinnon, Andrew L., primary, Parlati, Francesco, primary, Rodriguez, Mirna L.M., primary, Shwonek, Peter J., primary, Sjogren, Eric B., primary, Stanton, Timothy F., primary, Wang, Taotao, primary, Yang, Jinfu, primary, Zhao, Frances, primary, and Bennett, Mark K., primary

Published
2023
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24. Data from Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer

Author

Gross, Matt I., primary, Demo, Susan D., primary, Dennison, Jennifer B., primary, Chen, Lijing, primary, Chernov-Rogan, Tania, primary, Goyal, Bindu, primary, Janes, Julie R., primary, Laidig, Guy J., primary, Lewis, Evan R., primary, Li, Jim, primary, MacKinnon, Andrew L., primary, Parlati, Francesco, primary, Rodriguez, Mirna L.M., primary, Shwonek, Peter J., primary, Sjogren, Eric B., primary, Stanton, Timothy F., primary, Wang, Taotao, primary, Yang, Jinfu, primary, Zhao, Frances, primary, and Bennett, Mark K., primary

Published
2023
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25. Data from Dual Inhibition of Tumor Energy Pathway by 2-Deoxyglucose and Metformin Is Effective against a Broad Spectrum of Preclinical Cancer Models

Author

Cheong, Jae-Ho, primary, Park, Eun Sung, primary, Liang, Jiyong, primary, Dennison, Jennifer B., primary, Tsavachidou, Dimitra, primary, Nguyen-Charles, Catherine, primary, Wa Cheng, Kwai, primary, Hall, Hassan, primary, Zhang, Dong, primary, Lu, Yiling, primary, Ravoori, Murali, primary, Kundra, Vikas, primary, Ajani, Jaffer, primary, Lee, Ju-Seog, primary, Ki Hong, Waun, primary, and Mills, Gordon B., primary

Published
2023
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26. Supplementary Materials and Methods from Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer

Author

Gross, Matt I., primary, Demo, Susan D., primary, Dennison, Jennifer B., primary, Chen, Lijing, primary, Chernov-Rogan, Tania, primary, Goyal, Bindu, primary, Janes, Julie R., primary, Laidig, Guy J., primary, Lewis, Evan R., primary, Li, Jim, primary, MacKinnon, Andrew L., primary, Parlati, Francesco, primary, Rodriguez, Mirna L.M., primary, Shwonek, Peter J., primary, Sjogren, Eric B., primary, Stanton, Timothy F., primary, Wang, Taotao, primary, Yang, Jinfu, primary, Zhao, Frances, primary, and Bennett, Mark K., primary

Published
2023
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27. Supplementary Figures 1-3, Tables 1-2 from Dual Inhibition of Tumor Energy Pathway by 2-Deoxyglucose and Metformin Is Effective against a Broad Spectrum of Preclinical Cancer Models

Author

Cheong, Jae-Ho, primary, Park, Eun Sung, primary, Liang, Jiyong, primary, Dennison, Jennifer B., primary, Tsavachidou, Dimitra, primary, Nguyen-Charles, Catherine, primary, Wa Cheng, Kwai, primary, Hall, Hassan, primary, Zhang, Dong, primary, Lu, Yiling, primary, Ravoori, Murali, primary, Kundra, Vikas, primary, Ajani, Jaffer, primary, Lee, Ju-Seog, primary, Ki Hong, Waun, primary, and Mills, Gordon B., primary

Published
2023
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28. Supplementary Figure 5 from Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer

Author

Gross, Matt I., primary, Demo, Susan D., primary, Dennison, Jennifer B., primary, Chen, Lijing, primary, Chernov-Rogan, Tania, primary, Goyal, Bindu, primary, Janes, Julie R., primary, Laidig, Guy J., primary, Lewis, Evan R., primary, Li, Jim, primary, MacKinnon, Andrew L., primary, Parlati, Francesco, primary, Rodriguez, Mirna L.M., primary, Shwonek, Peter J., primary, Sjogren, Eric B., primary, Stanton, Timothy F., primary, Wang, Taotao, primary, Yang, Jinfu, primary, Zhao, Frances, primary, and Bennett, Mark K., primary

Published
2023
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29. Supplementary Figure 1 from Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer

Author

Gross, Matt I., primary, Demo, Susan D., primary, Dennison, Jennifer B., primary, Chen, Lijing, primary, Chernov-Rogan, Tania, primary, Goyal, Bindu, primary, Janes, Julie R., primary, Laidig, Guy J., primary, Lewis, Evan R., primary, Li, Jim, primary, MacKinnon, Andrew L., primary, Parlati, Francesco, primary, Rodriguez, Mirna L.M., primary, Shwonek, Peter J., primary, Sjogren, Eric B., primary, Stanton, Timothy F., primary, Wang, Taotao, primary, Yang, Jinfu, primary, Zhao, Frances, primary, and Bennett, Mark K., primary

Published
2023
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30. Supplementary Figure 6 from Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer

Author

Gross, Matt I., primary, Demo, Susan D., primary, Dennison, Jennifer B., primary, Chen, Lijing, primary, Chernov-Rogan, Tania, primary, Goyal, Bindu, primary, Janes, Julie R., primary, Laidig, Guy J., primary, Lewis, Evan R., primary, Li, Jim, primary, MacKinnon, Andrew L., primary, Parlati, Francesco, primary, Rodriguez, Mirna L.M., primary, Shwonek, Peter J., primary, Sjogren, Eric B., primary, Stanton, Timothy F., primary, Wang, Taotao, primary, Yang, Jinfu, primary, Zhao, Frances, primary, and Bennett, Mark K., primary

Published
2023
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31. Supplementary Figure 3 from Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer

Author

Gross, Matt I., primary, Demo, Susan D., primary, Dennison, Jennifer B., primary, Chen, Lijing, primary, Chernov-Rogan, Tania, primary, Goyal, Bindu, primary, Janes, Julie R., primary, Laidig, Guy J., primary, Lewis, Evan R., primary, Li, Jim, primary, MacKinnon, Andrew L., primary, Parlati, Francesco, primary, Rodriguez, Mirna L.M., primary, Shwonek, Peter J., primary, Sjogren, Eric B., primary, Stanton, Timothy F., primary, Wang, Taotao, primary, Yang, Jinfu, primary, Zhao, Frances, primary, and Bennett, Mark K., primary

Published
2023
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32. Supplementary Figure 7 from Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer

Author

Gross, Matt I., primary, Demo, Susan D., primary, Dennison, Jennifer B., primary, Chen, Lijing, primary, Chernov-Rogan, Tania, primary, Goyal, Bindu, primary, Janes, Julie R., primary, Laidig, Guy J., primary, Lewis, Evan R., primary, Li, Jim, primary, MacKinnon, Andrew L., primary, Parlati, Francesco, primary, Rodriguez, Mirna L.M., primary, Shwonek, Peter J., primary, Sjogren, Eric B., primary, Stanton, Timothy F., primary, Wang, Taotao, primary, Yang, Jinfu, primary, Zhao, Frances, primary, and Bennett, Mark K., primary

Published
2023
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33. Supplementary Figure 4 from Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer

Author

Gross, Matt I., primary, Demo, Susan D., primary, Dennison, Jennifer B., primary, Chen, Lijing, primary, Chernov-Rogan, Tania, primary, Goyal, Bindu, primary, Janes, Julie R., primary, Laidig, Guy J., primary, Lewis, Evan R., primary, Li, Jim, primary, MacKinnon, Andrew L., primary, Parlati, Francesco, primary, Rodriguez, Mirna L.M., primary, Shwonek, Peter J., primary, Sjogren, Eric B., primary, Stanton, Timothy F., primary, Wang, Taotao, primary, Yang, Jinfu, primary, Zhao, Frances, primary, and Bennett, Mark K., primary

Published
2023
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34. Supplementary Data from A Blood-Based Metabolite Panel for Distinguishing Ovarian Cancer from Benign Pelvic Masses

Author

Irajizad, Ehsan, primary, Han, Chae Y., primary, Celestino, Joseph, primary, Wu, Ranran, primary, Murage, Eunice, primary, Spencer, Rachelle, primary, Dennison, Jennifer B., primary, Vykoukal, Jody, primary, Long, James P., primary, Do, Kim Anh, primary, Drescher, Charles, primary, Lu, Karen, primary, Lu, Zhen, primary, Bast, Robert C., primary, Hanash, Sam, primary, and Fahrmann, Johannes F., primary

Published
2023
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35. Supplementary Figure from A Blood-Based Metabolite Panel for Distinguishing Ovarian Cancer from Benign Pelvic Masses

Author

Irajizad, Ehsan, primary, Han, Chae Y., primary, Celestino, Joseph, primary, Wu, Ranran, primary, Murage, Eunice, primary, Spencer, Rachelle, primary, Dennison, Jennifer B., primary, Vykoukal, Jody, primary, Long, James P., primary, Do, Kim Anh, primary, Drescher, Charles, primary, Lu, Karen, primary, Lu, Zhen, primary, Bast, Robert C., primary, Hanash, Sam, primary, and Fahrmann, Johannes F., primary

Published
2023
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36. Supplementary Table 1 from MCAM Mediates Chemoresistance in Small-Cell Lung Cancer via the PI3K/AKT/SOX2 Signaling Pathway

Author

Tripathi, Satyendra C., primary, Fahrmann, Johannes F., primary, Celiktas, Muge, primary, Aguilar, Mitzi, primary, Marini, Kieren D., primary, Jolly, Mohit K., primary, Katayama, Hiroyuki, primary, Wang, Hong, primary, Murage, Eunice N., primary, Dennison, Jennifer B., primary, Watkins, D. Neil, primary, Levine, Herbert, primary, Ostrin, Edwin J., primary, Taguchi, Ayumu, primary, and Hanash, Samir M., primary

Published
2023
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37. Data from MCAM Mediates Chemoresistance in Small-Cell Lung Cancer via the PI3K/AKT/SOX2 Signaling Pathway

Author

Tripathi, Satyendra C., primary, Fahrmann, Johannes F., primary, Celiktas, Muge, primary, Aguilar, Mitzi, primary, Marini, Kieren D., primary, Jolly, Mohit K., primary, Katayama, Hiroyuki, primary, Wang, Hong, primary, Murage, Eunice N., primary, Dennison, Jennifer B., primary, Watkins, D. Neil, primary, Levine, Herbert, primary, Ostrin, Edwin J., primary, Taguchi, Ayumu, primary, and Hanash, Samir M., primary

Published
2023
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38. Supplementary Table 3 from High Intratumoral Stromal Content Defines Reactive Breast Cancer as a Low-risk Breast Cancer Subtype

Author

Dennison, Jennifer B., primary, Shahmoradgoli, Maria, primary, Liu, Wenbin, primary, Ju, Zhenlin, primary, Meric-Bernstam, Funda, primary, Perou, Charles M., primary, Sahin, Aysegul A., primary, Welm, Alana, primary, Oesterreich, Steffi, primary, Sikora, Matthew J., primary, Brown, Robert E., primary, and Mills, Gordon B., primary

Published
2023
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39. Supplementary Data from Lactate Dehydrogenase B: A Metabolic Marker of Response to Neoadjuvant Chemotherapy in Breast Cancer

Author

Dennison, Jennifer B., primary, Molina, Jennifer R., primary, Mitra, Shreya, primary, González-Angulo, Ana M., primary, Balko, Justin M., primary, Kuba, María G., primary, Sanders, Melinda E., primary, Pinto, Joseph A., primary, Gómez, Henry L., primary, Arteaga, Carlos L., primary, Brown, Robert E., primary, and Mills, Gordon B., primary

Published
2023
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40. Supplementary Figures from Lactate Dehydrogenase B: A Metabolic Marker of Response to Neoadjuvant Chemotherapy in Breast Cancer

Author

Dennison, Jennifer B., primary, Molina, Jennifer R., primary, Mitra, Shreya, primary, González-Angulo, Ana M., primary, Balko, Justin M., primary, Kuba, María G., primary, Sanders, Melinda E., primary, Pinto, Joseph A., primary, Gómez, Henry L., primary, Arteaga, Carlos L., primary, Brown, Robert E., primary, and Mills, Gordon B., primary

Published
2023
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41. Supplementary Tables from Lactate Dehydrogenase B: A Metabolic Marker of Response to Neoadjuvant Chemotherapy in Breast Cancer

Author

Dennison, Jennifer B., primary, Molina, Jennifer R., primary, Mitra, Shreya, primary, González-Angulo, Ana M., primary, Balko, Justin M., primary, Kuba, María G., primary, Sanders, Melinda E., primary, Pinto, Joseph A., primary, Gómez, Henry L., primary, Arteaga, Carlos L., primary, Brown, Robert E., primary, and Mills, Gordon B., primary

Published
2023
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42. Supplementary Table 2 from MCAM Mediates Chemoresistance in Small-Cell Lung Cancer via the PI3K/AKT/SOX2 Signaling Pathway

Author

Tripathi, Satyendra C., primary, Fahrmann, Johannes F., primary, Celiktas, Muge, primary, Aguilar, Mitzi, primary, Marini, Kieren D., primary, Jolly, Mohit K., primary, Katayama, Hiroyuki, primary, Wang, Hong, primary, Murage, Eunice N., primary, Dennison, Jennifer B., primary, Watkins, D. Neil, primary, Levine, Herbert, primary, Ostrin, Edwin J., primary, Taguchi, Ayumu, primary, and Hanash, Samir M., primary

Published
2023
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43. Supplementary Table 4 from High Intratumoral Stromal Content Defines Reactive Breast Cancer as a Low-risk Breast Cancer Subtype

Author

Dennison, Jennifer B., primary, Shahmoradgoli, Maria, primary, Liu, Wenbin, primary, Ju, Zhenlin, primary, Meric-Bernstam, Funda, primary, Perou, Charles M., primary, Sahin, Aysegul A., primary, Welm, Alana, primary, Oesterreich, Steffi, primary, Sikora, Matthew J., primary, Brown, Robert E., primary, and Mills, Gordon B., primary

Published
2023
Full Text
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44. Supplementary Figures from MCAM Mediates Chemoresistance in Small-Cell Lung Cancer via the PI3K/AKT/SOX2 Signaling Pathway

Author

Tripathi, Satyendra C., primary, Fahrmann, Johannes F., primary, Celiktas, Muge, primary, Aguilar, Mitzi, primary, Marini, Kieren D., primary, Jolly, Mohit K., primary, Katayama, Hiroyuki, primary, Wang, Hong, primary, Murage, Eunice N., primary, Dennison, Jennifer B., primary, Watkins, D. Neil, primary, Levine, Herbert, primary, Ostrin, Edwin J., primary, Taguchi, Ayumu, primary, and Hanash, Samir M., primary

Published
2023
Full Text
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45. Supplementary Data from MCAM Mediates Chemoresistance in Small-Cell Lung Cancer via the PI3K/AKT/SOX2 Signaling Pathway

Author

Tripathi, Satyendra C., primary, Fahrmann, Johannes F., primary, Celiktas, Muge, primary, Aguilar, Mitzi, primary, Marini, Kieren D., primary, Jolly, Mohit K., primary, Katayama, Hiroyuki, primary, Wang, Hong, primary, Murage, Eunice N., primary, Dennison, Jennifer B., primary, Watkins, D. Neil, primary, Levine, Herbert, primary, Ostrin, Edwin J., primary, Taguchi, Ayumu, primary, and Hanash, Samir M., primary

Published
2023
Full Text
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46. Supplementary Materials from High Intratumoral Stromal Content Defines Reactive Breast Cancer as a Low-risk Breast Cancer Subtype

Author

Dennison, Jennifer B., primary, Shahmoradgoli, Maria, primary, Liu, Wenbin, primary, Ju, Zhenlin, primary, Meric-Bernstam, Funda, primary, Perou, Charles M., primary, Sahin, Aysegul A., primary, Welm, Alana, primary, Oesterreich, Steffi, primary, Sikora, Matthew J., primary, Brown, Robert E., primary, and Mills, Gordon B., primary

Published
2023
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47. Blood-based proteomic signatures associated with MEN1-related Duodenopancreatic Neuroendocrine Tumor Progression

Author

Cancer, MS Endocriene Oncologie, Heelkunde Opleiding, MS CGO, Fahrmann, Johannes F, Wasylishen, Amanda R, Pieterman, Carolina R C, Irajizad, Ehsan, Vykoukal, Jody, Wu, Ranran, Dennison, Jennifer B, Peterson, Christine B, Zhao, Hua, Do, Kim-Anh, Halperin, Daniel M, Agarwal, Sunita K, Blau, Jenny E, Jha, Smita, Rivero, Jaydira Del, Nilubol, Naris, Walter, Mary F, Welch, James M, Weinstein, Lee S, Vriens, Menno R, van Leeuwaarde, Rachel S, van Treijen, Mark J C, Valk, Gerlof D, Perrier, Nancy D, Hanash, Samir M, Katayama, Hiroyuki, Cancer, MS Endocriene Oncologie, Heelkunde Opleiding, MS CGO, Fahrmann, Johannes F, Wasylishen, Amanda R, Pieterman, Carolina R C, Irajizad, Ehsan, Vykoukal, Jody, Wu, Ranran, Dennison, Jennifer B, Peterson, Christine B, Zhao, Hua, Do, Kim-Anh, Halperin, Daniel M, Agarwal, Sunita K, Blau, Jenny E, Jha, Smita, Rivero, Jaydira Del, Nilubol, Naris, Walter, Mary F, Welch, James M, Weinstein, Lee S, Vriens, Menno R, van Leeuwaarde, Rachel S, van Treijen, Mark J C, Valk, Gerlof D, Perrier, Nancy D, Hanash, Samir M, and Katayama, Hiroyuki

Published
2023

48. Kynureninase Upregulation Is a Prominent Feature of NFR2-Activated Cancers and Is Associated with Tumor Immunosuppression and Poor Prognosis

Author

León-Letelier, Ricardo A., primary, Abdel Sater, Ali H., additional, Chen, Yihui, additional, Park, Soyoung, additional, Wu, Ranran, additional, Irajizad, Ehsan, additional, Dennison, Jennifer B., additional, Katayama, Hiroyuki, additional, Vykoukal, Jody V., additional, Hanash, Samir, additional, Ostrin, Edwin J., additional, and Fahrmann, Johannes F., additional

Published
2023
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50. Abstract P076: Contribution of the microbiome to a metabolomic signature predictive of risk for pancreatic cancer

Author

Fahrmann, Johannes F., primary, Irajizad, Ehsan, additional, Kenney, Ana, additional, Tang, Tiffany, additional, Vykoukal, Jody, additional, Wu, Ranran, additional, Dennison, Jennifer B., additional, Escofet, Marta Sans, additional, Long, James P., additional, Loftus, Maureen, additional, Chabot, John A., additional, Kluger, Michael D., additional, Kastrinos, Fay, additional, Brais, Lauren, additional, Babic, Ana, additional, Jajoo, Kunal, additional, Lee, Linda S., additional, Clancy, Thomas E., additional, Ng, Kimmie, additional, Bullock, Andrea, additional, Genkinger, Jeanine M., additional, Maitra, Anirban, additional, Do, Kim-Anh, additional, Yu, Bin, additional, Wolpin, Brian M., additional, and Hanash, Samir, additional

Published
2023
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