1. A comprehensive analysis of penile cancer in the region with the highest worldwide incidence reveals new insights into the disease
- Author
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Antonio Augusto Lima Teixeira Júnior, Syomara Pereira da Costa Melo, Jaqueline Diniz Pinho, Thaís Bastos Moraes Sobrinho, Thalita Moura Silva Rocha, Denner Rodrigo Diniz Duarte, Liseana de Oliveira Barbosa, Wesliany Everton Duarte, Marta Regina de Castro Belfort, Kelly Gomes Duarte, Antonio Lima da Silva Neto, José de Ribamar Rodrigues Calixto, Lúcio Cristiano Paiva Paiva, Francisco Sérgio Moura Silva do Nascimento, Antonio Machado Alencar Junior, André Salim Khayat, Rita da Graça Carvalhal Frazão Corrêa, Joyce Santos Lages, Rodolfo Borges dos Reis, Wilson Silva Araújo, and Gyl Eanes Barros Silva
- Subjects
Penile cancer ,HPV ,p16 ,p53 ,Ki-67 ,Maranhão ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Although penile cancer (PC) is uncommon in developed countries, it is widespread in developing countries. The state of Maranhão (Northeast, Brazil) has the highest global incidence recorded for PC, and, despite its socioeconomic vulnerability, it has been attributed to human papillomavirus (HPV) infection. This study aimed to determine the histopathological features, the prevalence of HPV infection, and the immunohistochemical profile of PC in Maranhão. Methods A retrospective cohort of 200 PC cases were evaluated. HPV detection was performed using nested-PCR followed by direct sequencing for genotyping. Immunohistochemistry (IHC) was performed using monoclonal antibodies anti-p16INK4a, p53, and ki-67. Results Our data revealed a delay of 17 months in diagnosis, a high rate of penile amputation (96.5%), and HPV infection (80.5%) in patients from Maranhão (Molecular detection). We demonstrated the high rate of HPV in PC also by histopathological and IHC analysis. Most patients presented koilocytosis (75.5%), which was associated with those reporting more than 10 different sexual partners during their lifetime (p = 0.001). IHC revealed frequent p16INK4a overexpression (26.0%) associated with basaloid (p
- Published
- 2022
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