4 results on '"Denitto, Claudio"'
Search Results
2. COVID-19 Perfect Storm (Part II): Role of Vitamins as Therapy or Preventive Strategy in Aged People
- Author
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Fiorino, Sirio, Gallo, Claudio, Zippi, Maddalena, Sabbatani, Sergio, Manfredi, Roberto, Moretti, Renzo, Fogacci, Elisa, Maggioli, Caterina, Loffredo, Francesca Travasoni, Giampieri, Enrico, Corazza, Ivan, Dickmans, Christoph, Denitto, Claudio, Cammarosano, Michele, Battilana, Michele, Orlandi, Paolo Emilio, Forno, Francesco Del, Miceli, Francesco, Visani, Michela, Acquaviva, Giorgia, Leandri, Paolo, Jovine, Elio, Iovine, Roberto, and Biase, Dario de
- Subjects
pathology_pathobiology - Abstract
Objectives: In December 2019 a novel human-infecting coronavirus, SARS-CoV-2, has emerged. The WHO has stated the epidemic as a “public health emergency of international concern”. A dramatic situation has emerged with thousands of deaths, occurring mainly in the aged and very ill people. Epidemiological studies suggest that immune system function is impaired in elderly individuals and these subjects often present a severe deficiency in nutrients as fatsoluble and hydrosoluble vitamins. Design: In this second part of the review about Cov2 in aged people, we searched for studies describing the possible efficacy of vitamins A, D, E and C in improving the immune system function and their possible activities against viruses. Results: Vitamins may shift the proinflammatory Th17 mediated immune-response arising in the autoimmune diseases towards a T-cell regulatory phenotype. These diseases may serve as a paradigm for the study of CRS emerging in the course of SARS CoV-2 infection. Conclusion: This review discusses about the possible activity of Vitamin A, D, E and C in restoring normal antiviral Immune System function or the potential therapeutic role of these micronutrients as a part of a multi-treatment strategy against SARS-CoV-2 infection.
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- 2020
3. COVID-19 Perfect Storm (Part I): Cytokine Release Syndrome in Aged People
- Author
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Fiorino, Sirio, Gallo, Claudio, Zippi, Maddalena, Sabbatani, Sergio, Manfredi, Roberto, Moretti, Renzo, Fogacci, Elisa, Maggioli, Caterina, Loffredo, Francesca Travasoni, Giampieri, Enrico, Corazza, Ivan, Dickmans, Christoph, Denitto, Claudio, Cammarosano, Michele, Battilana, Michele, Orlandi, Paolo Emilio, Forno, Francesco Del, Miceli, Francesco, Visani, Michela, Acquaviva, Giorgia, Leandri, Paolo, Jovine, Elio, Jovine, Roberto, and Biase, Dario de
- Subjects
pathology_pathobiology - Abstract
Objectives: In December 2019 a novel human-infecting coronavirus, SARS-CoV-2, has emerged. The WHO has stated the epidemic as a “public health emergency of international concern”. A drammatic situation has emerged with thousands of deaths, occurring mainly in the aged and very ill people. Epidemiological studies suggest that immune system function is impaired in elderly individuals and these subjects often present a severe deficiency in nutrients as fatsoluble and hydrosoluble vitamins. Design: In this first part of the review about Cov2 in aged people, we searched for reviews describing the characteristics of autoimmune diseases and the available therapeutic protocols for their treatment. We sed them as a paradigm with the purpose to retrieve pathogenetic mechanisms in common among these pathological conditions and SARS-CoV-2 infection, as well as the alteration induced in immune system function by this virus, or by its homologous SARS-CoV. Results: SARS-CoV-2 infection induces an important immune system dysfunction with the development of an exhuberant proinflammatory response in the host, and with the development of a life-threatening condition defined as Cytokine Release Syndrome (CRS). This leads to the Acute Respiratory Syndrome (ARDS), mainly in the aged people. High mortality and lethality rates have been observed in the elderly subjects with CoV-2-related infection. Conclusion: These diseases may serve as a paradigm for the study of CRS emerging in the course of SARS CoV-2 infection. This review discusses about the possible activity of Vitamin A, D, E and C in restoring normal antiviral Immune System function or the potential therapeutic role of these micronutrients as a part of a multi-treatment strategy against SARS- CoV-2 infection.
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- 2020
4. Cytokine storm in aged people with CoV-2: possible role of vitamins as therapy or preventive strategy
- Author
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Ivan Corazza, Roberto Manfredi, Christoph Dickmans, Claudio Denitto, Paolo Emilio Orlandi, Enrico Giampieri, Caterina Maggioli, Giovanni Tallini, Antonio De Leo, Sirio Fiorino, Elio Jovine, Michela Visani, Francesco Del Forno, Paolo Leandri, Claudio Gallo, Michele Cammarosano, Maddalena Zippi, Thomas Brand, Francesco Miceli, Giorgia Acquaviva, Elisa Fogacci, Roberto Jovine, Sergio Sabbatani, Michele Battilana, Dario de Biase, Francesca Travasoni Loffredo, Wandong Hong, Renzo Moretti, Fiorino, Sirio, Gallo, Claudio, Zippi, Maddalena, Sabbatani, Sergio, Manfredi, Roberto, Moretti, Renzo, Fogacci, Elisa, Maggioli, Caterina, Travasoni Loffredo, Francesca, Giampieri, Enrico, Corazza, Ivan, Dickmans, Christoph, Denitto, Claudio, Cammarosano, Michele, Battilana, Michele, Orlandi, Paolo Emilio, Del Forno, Francesco, Miceli, Francesco, Visani, Michela, Acquaviva, Giorgia, De Leo, Antonio, Leandri, Paolo, Hong, Wandong, Brand, Thoma, Tallini, Giovanni, Jovine, Elio, Jovine, Roberto, and de Biase, Dario
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Aging ,ARDS ,medicine.medical_specialty ,Pneumonia, Viral ,Review ,Ascorbic Acid ,medicine.disease_cause ,Proinflammatory cytokine ,Betacoronavirus ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,CoV-2 ,Epidemiology ,Humans ,Vitamin E ,Medicine ,030212 general & internal medicine ,Vitamin D ,Vitamin A ,Pandemics ,Pathological ,Aged ,030304 developmental biology ,Coronavirus ,SARS ,0303 health sciences ,SARS-CoV-2 ,business.industry ,COVID-19 ,Vitamins ,medicine.disease ,Ageing ,Cytokine release syndrome ,Immunology ,Cytokines ,Th17 Cells ,Therapeutic strategy ,Geriatrics and Gerontology ,Coronavirus Infections ,business ,Cytokine storm - Abstract
Background In December 2019, a novel human-infecting coronavirus, SARS-CoV-2, had emerged. The WHO has classified the epidemic as a “public health emergency of international concern”. A dramatic situation has unfolded with thousands of deaths, occurring mainly in the aged and very ill people. Epidemiological studies suggest that immune system function is impaired in elderly individuals and these subjects often present a deficiency in fat-soluble and hydrosoluble vitamins. Methods We searched for reviews describing the characteristics of autoimmune diseases and the available therapeutic protocols for their treatment. We set them as a paradigm with the purpose to uncover common pathogenetic mechanisms between these pathological conditions and SARS-CoV-2 infection. Furthermore, we searched for studies describing the possible efficacy of vitamins A, D, E, and C in improving the immune system function. Results SARS-CoV-2 infection induces strong immune system dysfunction characterized by the development of an intense proinflammatory response in the host, and the development of a life-threatening condition defined as cytokine release syndrome (CRS). This leads to acute respiratory syndrome (ARDS), mainly in aged people. High mortality and lethality rates have been observed in elderly subjects with CoV-2-related infection. Conclusions Vitamins may shift the proinflammatory Th17-mediated immune response arising in autoimmune diseases towards a T-cell regulatory phenotype. This review discusses the possible activity of vitamins A, D, E, and C in restoring normal antiviral immune system function and the potential therapeutic role of these micronutrients as part of a therapeutic strategy against SARS-CoV-2 infection.
- Published
- 2020
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