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4. Walking naturally after spinal cord injury using a brain–spine interface

Author

Lorach, Henri, Galvez, Andrea, Spagnolo, Valeria, Martel, Felix, Karakas, Serpil, Intering, Nadine, Vat, Molywan, Faivre, Olivier, Harte, Cathal, Komi, Salif, Ravier, Jimmy, Collin, Thibault, Coquoz, Laure, Sakr, Icare, Baaklini, Edeny, Hernandez-Charpak, Sergio Daniel, Dumont, Gregory, Buschman, Rik, Buse, Nicholas, Denison, Tim, van Nes, Ilse, Asboth, Leonie, Watrin, Anne, Struber, Lucas, Sauter-Starace, Fabien, Langar, Lilia, Auboiroux, Vincent, Carda, Stefano, Chabardes, Stephan, Aksenova, Tetiana, Demesmaeker, Robin, Charvet, Guillaume, Bloch, Jocelyne, and Courtine, Grégoire

Published
2023
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6. Semi-supervised training data selection improves seizure forecasting in canines with epilepsy

Author

Nasseri, Mona, Kremen, Vaclav, Nejedly, Petr, Kim, Inyong, Chang, Su-Youne, Jo, Hang Joon, Guragain, Hari, Nelson, Nathaniel, Patterson, Edward, Sturges, Beverly K, Crowe, Chelsea M, Denison, Tim, Brinkmann, Benjamin H, and Worrell, Gregory A

Subjects
Agricultural, Veterinary and Food Sciences, Engineering, Food Sciences, Biomedical Engineering, Neurodegenerative, Epilepsy, Brain Disorders, Neurosciences, Neurological, Hierarchical clustering, Machine learning, Seizure forecasting, Electrical and Electronic Engineering, Medical Biotechnology, Food sciences, Biomedical engineering
Abstract

Conventional selection of pre-ictal EEG epochs for seizure prediction algorithm training data typically assumes a continuous pre-ictal brain state preceding a seizure. This is carried out by defining a fixed duration, pre-ictal time period before seizures from which pre-ictal training data epochs are uniformly sampled. However, stochastic physiological and pathological fluctuations in EEG data characteristics and underlying brain states suggest that pre-ictal state dynamics may be more complex, and selection of pre-ictal training data segments to reflect this could improve algorithm performance. We propose a semi-supervised technique to select pre-ictal training data most distinguishable from interictal EEG according to pre-specified data characteristics. The proposed method uses hierarchical clustering to identify optimal pre-ictal data epochs. In this paper we compare the performance of a seizure forecasting algorithm with and without hierarchical clustering of pre-ictal periods in chronic iEEG recordings from six canines with naturally occurring epilepsy. Hierarchical clustering of training data improved results for Time In Warning (TIW) (0.18 vs. 0.23) and False Positive Rate (FPR) (0.5 vs. 0.59) when evaluated across all subjects (p

Published
2020

7. Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis

Author

Rowald, Andreas, Komi, Salif, Demesmaeker, Robin, Baaklini, Edeny, Hernandez-Charpak, Sergio Daniel, Paoles, Edoardo, Montanaro, Hazael, Cassara, Antonino, Becce, Fabio, Lloyd, Bryn, Newton, Taylor, Ravier, Jimmy, Kinany, Nawal, D’Ercole, Marina, Paley, Aurélie, Hankov, Nicolas, Varescon, Camille, McCracken, Laura, Vat, Molywan, Caban, Miroslav, Watrin, Anne, Jacquet, Charlotte, Bole-Feysot, Léa, Harte, Cathal, Lorach, Henri, Galvez, Andrea, Tschopp, Manon, Herrmann, Natacha, Wacker, Moïra, Geernaert, Lionel, Fodor, Isabelle, Radevich, Valentin, Van Den Keybus, Katrien, Eberle, Grégoire, Pralong, Etienne, Roulet, Maxime, Ledoux, Jean-Baptiste, Fornari, Eleonora, Mandija, Stefano, Mattera, Loan, Martuzzi, Roberto, Nazarian, Bruno, Benkler, Stefan, Callegari, Simone, Greiner, Nathan, Fuhrer, Benjamin, Froeling, Martijn, Buse, Nik, Denison, Tim, Buschman, Rik, Wende, Christian, Ganty, Damien, Bakker, Jurriaan, Delattre, Vincent, Lambert, Hendrik, Minassian, Karen, van den Berg, Cornelis A. T., Kavounoudias, Anne, Micera, Silvestro, Van De Ville, Dimitri, Barraud, Quentin, Kurt, Erkan, Kuster, Niels, Neufeld, Esra, Capogrosso, Marco, Asboth, Leonie, Wagner, Fabien B., Bloch, Jocelyne, and Courtine, Grégoire

Published
2022
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9. Proceedings of the Eighth International Workshop on Advances in Electrocorticography

Author

Ritaccio, Anthony L, Williams, Justin, Denison, Tim, Foster, Brett L, Starr, Philip A, Gunduz, Aysegul, Zijlmans, Maeike, and Schalk, Gerwin

Subjects
Biomedical Research, Brain, Brain Mapping, Electrocorticography, Humans, Brain-computer interface, Responsive neurostimulation, High-frequency oscillations, Thalamocortical networks, Neuromodulation, Flexible electronics, Brain–computer interface, Clinical Sciences, Neurology & Neurosurgery
Abstract

Excerpted proceedings of the Eighth International Workshop on Advances in Electrocorticography (ECoG), which convened October 15-16, 2015 in Chicago, IL, are presented. The workshop series has become the foremost gathering to present current basic and clinical research in subdural brain signal recording and analysis.

Published
2016

10. Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury

Author

Squair, Jordan W., Gautier, Matthieu, Mahe, Lois, Soriano, Jan Elaine, Rowald, Andreas, Bichat, Arnaud, Cho, Newton, Anderson, Mark A., James, Nicholas D., Gandar, Jerome, Incognito, Anthony V., Schiavone, Giuseppe, Sarafis, Zoe K., Laskaratos, Achilleas, Bartholdi, Kay, Demesmaeker, Robin, Komi, Salif, Moerman, Charlotte, Vaseghi, Bita, Scott, Berkeley, Rosentreter, Ryan, Kathe, Claudia, Ravier, Jimmy, McCracken, Laura, Kang, Xiaoyang, Vachicouras, Nicolas, Fallegger, Florian, Jelescu, Ileana, Cheng, YunLong, Li, Qin, Buschman, Rik, Buse, Nicolas, Denison, Tim, Dukelow, Sean, Charbonneau, Rebecca, Rigby, Ian, Boyd, Steven K., Millar, Philip J., Moraud, Eduardo Martin, Capogrosso, Marco, Wagner, Fabien B., Barraud, Quentin, Bezard, Erwan, Lacour, Stéphanie P., Bloch, Jocelyne, Courtine, Grégoire, and Phillips, Aaron A.

Published
2021
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11. A translational platform for prototyping closed-loop neuromodulation systems.

Author

Afshar, Pedram, Stanslaski, Scott, Carlson, David, Jensen, Randy, Linde, Dave, Dani, Siddharth, Lazarewicz, Maciej, Cong, Peng, Giftakis, Jon, Stypulkowski, Paul, Denison, Tim, and Khambhati, Ankit

Subjects
automation, closed-loop, hippocampus, neuromodulation, prototyping, seizure
Abstract

While modulating neural activity through stimulation is an effective treatment for neurological diseases such as Parkinsons disease and essential tremor, an opportunity for improving neuromodulation therapy remains in automatically adjusting therapy to continuously optimize patient outcomes. Practical issues associated with achieving this include the paucity of human data related to disease states, poorly validated estimators of patient state, and unknown dynamic mappings of optimal stimulation parameters based on estimated states. To overcome these challenges, we present an investigational platform including: an implanted sensing and stimulation device to collect data and run automated closed-loop algorithms; an external tool to prototype classifier and control-policy algorithms; and real-time telemetry to update the implanted device firmware and monitor its state. The prototyping system was demonstrated in a chronic large animal model studying hippocampal dynamics. We used the platform to find biomarkers of the observed states and transfer functions of different stimulation amplitudes. Data showed that moderate levels of stimulation suppress hippocampal beta activity, while high levels of stimulation produce seizure-like after-discharge activity. The biomarker and transfer function observations were mapped into classifier and control-policy algorithms, which were downloaded to the implanted device to continuously titrate stimulation amplitude for the desired network effect. The platform is designed to be a flexible prototyping tool and could be used to develop improved mechanistic models and automated closed-loop systems for a variety of neurological disorders.

Published
2012

12. Targeted neurotechnology restores walking in humans with spinal cord injury

Author

Wagner, Fabien B., Mignardot, Jean-Baptiste, Le Goff-Mignardot, Camille G., Demesmaeker, Robin, Komi, Salif, Capogrosso, Marco, Rowald, Andreas, Seáñez, Ismael, Caban, Miroslav, Pirondini, Elvira, Vat, Molywan, McCracken, Laura A., Heimgartner, Roman, Fodor, Isabelle, Watrin, Anne, Seguin, Perrine, Paoles, Edoardo, Van Den Keybus, Katrien, Eberle, Grégoire, Schurch, Brigitte, Pralong, Etienne, Becce, Fabio, Prior, John, Buse, Nicholas, Buschman, Rik, Neufeld, Esra, Kuster, Niels, Carda, Stefano, von Zitzewitz, Joachim, Delattre, Vincent, Denison, Tim, Lambert, Hendrik, Minassian, Karen, Bloch, Jocelyne, and Courtine, Grégoire

Published
2018
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13. The management of technology transfer from research institutes to industry : isolating key components of process success and failure

Author

Denison, Tim J. and Knox, Simon

Subjects
658, Innovation, Industrial collaboration
Abstract

"Innovate or die" is a long-standing creed in industry. Collaboration between companies is one route that businesses are pursuing with vigour, in an effort to gain competitive advantage. Few UK companies look to the dedicated research institutes (DRDCs) that exist as a source of innovation and industrial collaboration. This is despite the high regard bestowed on the creative abilities of the scientific teams at these centres of excellence. The purpose of this study is not to answer why this is so, but to help improve the chances of success when it occurs. The study was born out of a Government-funded LINK project, which evaluated the benefits, to project commercialisation, of conducting market research in tandem with the technical stages of R&D at public research institutes. Exposure to the professional cultures, work ethos and personal attitudes of team-members at the DRDCs and their commercial partners alerted the researcher to the challenges presented by technology transfer between such organisations. The literature is populated by studies that detail the stresses and strains of technology transfer. However, little attention has been directed exclusively at cases involving DRDCs. The primary aim of the study is to identify the driving forces behind technology transfer success from DRDCs to industry. It draws on the framework of the IMP Group to structure the context of investigation. It uses the findings of past studies to structure the content of investigation. A qualitative approach involving 13 detailed case studies constitutes its methodology. The cases cover both public and privately-funded DRDCs in the UK and the Netherlands, including examples from agricultural engineering, food sciences and biotechnology. The results highlight seven key antecedents as areas at which good management practice should be targeted. The study concludes by addressing the underlying mechanisms behind transfer process success. It finds that it is too simplistic to focus on any one of the three dimensions of technology transfer (organisational, human and environmental) 'at the exclusion of the others, as past studies have done. Successful transfer is found to depend on three cross-dimensional underlying mechanisms:- • checking the innovation is appropriate to the recipient • establishing a suitable transfer process • and providing an effective conduit for routing the knowledge transfer.

Published
1999

14. A brainspine interface alleviating gait deficits after spinal cord injury in primates

Author

Capogrosso, Marco, Milekovic, Tomislav, Borton, David, Wagner, Fabien, Moraud, Eduardo Martin, Mignardot, Jean-Baptiste, Buse, Nicolas, Gandar, Jerome, Barraud, Quentin, Xing, David, Rey, Elodie, Duis, Simone, Jianzhong, Yang, Ko, Wai Kin D., Li, Qin, Detemple, Peter, Denison, Tim, Micera, Silvestro, Bezard, Erwan, Bloch, Jocelyne, and Courtine, Grgoire

Subjects
Physiological aspects, Health aspects, Primates -- Health aspects, Spinal cord injuries -- Physiological aspects, Gait -- Health aspects
Abstract

Author(s): Marco Capogrosso [1, 2]; Tomislav Milekovic [1]; David Borton [1, 3]; Fabien Wagner [1]; Eduardo Martin Moraud [2]; Jean-Baptiste Mignardot [1]; Nicolas Buse [4]; Jerome Gandar [1]; Quentin Barraud [...]

Published
2016
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17. Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis

Author

Computational Imaging, Cancer, Highfield Research Group, Brain, Circulatory Health, Rowald, Andreas, Komi, Salif, Demesmaeker, Robin, Baaklini, Edeny, Hernandez-Charpak, Sergio Daniel, Paoles, Edoardo, Montanaro, Hazael, Cassara, Antonino, Becce, Fabio, Lloyd, Bryn, Newton, Taylor, Ravier, Jimmy, Kinany, Nawal, D'Ercole, Marina, Paley, Aurélie, Hankov, Nicolas, Varescon, Camille, McCracken, Laura, Vat, Molywan, Caban, Miroslav, Watrin, Anne, Jacquet, Charlotte, Bole-Feysot, Léa, Harte, Cathal, Lorach, Henri, Galvez, Andrea, Tschopp, Manon, Herrmann, Natacha, Wacker, Moïra, Geernaert, Lionel, Fodor, Isabelle, Radevich, Valentin, Van Den Keybus, Katrien, Eberle, Grégoire, Pralong, Etienne, Roulet, Maxime, Ledoux, Jean-Baptiste, Fornari, Eleonora, Mandija, Stefano, Mattera, Loan, Martuzzi, Roberto, Nazarian, Bruno, Benkler, Stefan, Callegari, Simone, Greiner, Nathan, Fuhrer, Benjamin, Froeling, Martijn, Buse, Nik, Denison, Tim, Buschman, Rik, Wende, Christian, Ganty, Damien, Bakker, Jurriaan, Delattre, Vincent, Lambert, Hendrik, Minassian, Karen, van den Berg, Cornelis A T, Kavounoudias, Anne, Micera, Silvestro, Van De Ville, Dimitri, Barraud, Quentin, Kurt, Erkan, Kuster, Niels, Neufeld, Esra, Capogrosso, Marco, Asboth, Leonie, Wagner, Fabien B, Bloch, Jocelyne, Courtine, Grégoire, Computational Imaging, Cancer, Highfield Research Group, Brain, Circulatory Health, Rowald, Andreas, Komi, Salif, Demesmaeker, Robin, Baaklini, Edeny, Hernandez-Charpak, Sergio Daniel, Paoles, Edoardo, Montanaro, Hazael, Cassara, Antonino, Becce, Fabio, Lloyd, Bryn, Newton, Taylor, Ravier, Jimmy, Kinany, Nawal, D'Ercole, Marina, Paley, Aurélie, Hankov, Nicolas, Varescon, Camille, McCracken, Laura, Vat, Molywan, Caban, Miroslav, Watrin, Anne, Jacquet, Charlotte, Bole-Feysot, Léa, Harte, Cathal, Lorach, Henri, Galvez, Andrea, Tschopp, Manon, Herrmann, Natacha, Wacker, Moïra, Geernaert, Lionel, Fodor, Isabelle, Radevich, Valentin, Van Den Keybus, Katrien, Eberle, Grégoire, Pralong, Etienne, Roulet, Maxime, Ledoux, Jean-Baptiste, Fornari, Eleonora, Mandija, Stefano, Mattera, Loan, Martuzzi, Roberto, Nazarian, Bruno, Benkler, Stefan, Callegari, Simone, Greiner, Nathan, Fuhrer, Benjamin, Froeling, Martijn, Buse, Nik, Denison, Tim, Buschman, Rik, Wende, Christian, Ganty, Damien, Bakker, Jurriaan, Delattre, Vincent, Lambert, Hendrik, Minassian, Karen, van den Berg, Cornelis A T, Kavounoudias, Anne, Micera, Silvestro, Van De Ville, Dimitri, Barraud, Quentin, Kurt, Erkan, Kuster, Niels, Neufeld, Esra, Capogrosso, Marco, Asboth, Leonie, Wagner, Fabien B, Bloch, Jocelyne, and Courtine, Grégoire

Published
2022

30. Semi-supervised training data selection improves seizure forecasting in canines with epilepsy

Author

Nasseri, Mona, primary, Kremen, Vaclav, additional, Nejedly, Petr, additional, Kim, Inyong, additional, Chang, Su-Youne, additional, Jo, Hang Joon, additional, Guragain, Hari, additional, Nelson, Nathaniel, additional, Patterson, Edward, additional, Sturges, Beverly K., additional, Crowe, Chelsea M., additional, Denison, Tim, additional, Brinkmann, Benjamin H., additional, and Worrell, Gregory A., additional

Published
2020
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39. Proceedings of the Eighth International Workshop on Advances in Electrocorticography

Author

ZL Kinder Ner en Nec Medisch, Brain, Ritaccio, Anthony L., Williams, Justin, Denison, Tim, Foster, Brett L., Starr, Philip A., Gunduz, Aysegul, Zijlmans, Maeike, Schalk, Gerwin, ZL Kinder Ner en Nec Medisch, Brain, Ritaccio, Anthony L., Williams, Justin, Denison, Tim, Foster, Brett L., Starr, Philip A., Gunduz, Aysegul, Zijlmans, Maeike, and Schalk, Gerwin

Published
2016

40. A brain–spine interface alleviating gait deficits after spinal cord injury in primates

Author

Capogrosso, Marco, primary, Milekovic, Tomislav, additional, Borton, David, additional, Wagner, Fabien, additional, Moraud, Eduardo Martin, additional, Mignardot, Jean-Baptiste, additional, Buse, Nicolas, additional, Gandar, Jerome, additional, Barraud, Quentin, additional, Xing, David, additional, Rey, Elodie, additional, Duis, Simone, additional, Jianzhong, Yang, additional, Ko, Wai Kin D., additional, Li, Qin, additional, Detemple, Peter, additional, Denison, Tim, additional, Micera, Silvestro, additional, Bezard, Erwan, additional, Bloch, Jocelyne, additional, and Courtine, Grégoire, additional

Published
2016
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50. Plenary speakers: Reliable interfaces with the peripheral nervous system

Author

Durand, Dominique M., primary, Sejnowski, Terrence J., additional, Vitek, Jerrold L., additional, Akay, Metin, additional, Berger, Theodore W., additional, Cauwenberghs, Gert, additional, Courtine, Gregoire, additional, Denison, Tim, additional, Ding, Lei, additional, Edgerton, V. Reggie, additional, Farina, Dario, additional, Gao, Shangkai, additional, Grill, Warren M., additional, Guiraud, David, additional, He, Bin, additional, Humayun, Mark S., additional, Hu, Xiaoping, additional, Kuiken, Todd A., additional, Litt, Brian, additional, Liu, Yuan, additional, Lovell, Nigel, additional, Micera, Silvestro, additional, Miller, Lee E., additional, Peckham, P. Hunter, additional, Peng, Grace C. Y., additional, Principe, Jose C., additional, Sajda, Paul, additional, Sanchez, Justin C., additional, Schiff, Steven J., additional, Thakor, Nitish V., additional, Wheeler, Bruce, additional, White, John A., additional, Worrell, Greg, additional, and Ye, Kaiming, additional

Published
2013
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