156 results on '"Denis, Brigitte"'
Search Results
2. Prevalence of endemic respiratory viruses during the COVID-19 pandemic in urban and rural Malawi
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Vink, Elen, Banda, Louis, Amoah, Abena S, Kasenda, Stephen, Read, Jonathan M, Jewell, Chris, Denis, Brigitte, Mwale, Annie Chauma, Crampin, Amelia, Anscombe, Catherine, Menyere, Mavis, Ho, Antonia, Vink, Elen, Banda, Louis, Amoah, Abena S, Kasenda, Stephen, Read, Jonathan M, Jewell, Chris, Denis, Brigitte, Mwale, Annie Chauma, Crampin, Amelia, Anscombe, Catherine, Menyere, Mavis, and Ho, Antonia
- Abstract
BackgroundWe investigated endemic respiratory virus circulation patterns in Malawi, where no lockdown was imposed, during the COVID-19 pandemic.MethodsWithin a prospective household cohort in urban and rural Malawi, adult participants provided upper respiratory tract (URT) samples at 4 time points between February 2021 and April 2022. Polymerase chain reaction (PCR) was performed for SARS-CoV-2, influenza, and other endemic respiratory viruses.Results1626 URT samples from 945 participants in 542 households were included. Overall, 7.6% (n = 123) samples were PCR- positive for >1 respiratory virus; SARS-CoV-2 (4.4%) and rhinovirus (2.0%) were most common. No influenza A virus was detected. Influenza B and respiratory syncytial virus (RSV) were rare. Higher virus positivity were detected in the rural setting and at earlier time points. Coinfections were infrequent.ConclusionsEndemic respiratory viruses circulated in the community in Malawi during the pandemic, though influenza and RSV were rarely detected. Distinct differences in virus positivity and demographics were observed between urban and rural cohorts.
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- 2024
3. Changing Incidence of Invasive Pneumococcal Disease in Infants Less Than 90 Days of Age Before and After Introduction of the 13-Valent Pneumococcal Conjugate Vaccine in Blantyre, Malawi: A 14-Year Hospital Based Surveillance Study
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Koenraads, Marianne, Swarthout, Todd D., Bar-Zeev, Naor, Brown, Comfort, Msefula, Jacquline, Denis, Brigitte, Dube, Queen, Gordon, Stephen B., Heyderman, Robert S., Gladstone, Melissa J., and French, Neil
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- 2022
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4. Effect of ready-to-use supplementary food on mortality in severely immunocompromised HIV-infected individuals in Africa initiating antiretroviral therapy (REALITY): an open-label, parallel-group, randomised controlled trial
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Mugyenyi, Peter, Kityo, Cissy, Musiime, Victor, Wavamunno, Priscilla, Nambi, Esther, Ocitti, Paul, Ndigendawani, Milly, Kabahenda, Sheila, Kemigisa, Mable, Acen, Juliet, Olebo, David Francis, Mpamize, Gordon, Amone, Alex, Okweny, David, Mbonye, Andrew, Nambaziira, Florence, Rweyora, Angela, Kangah, Mary, Kabaswahili, Beatrice, Abach, James, Abongomera, George, Omongin, Joseph, Aciro, Irene, Philliam, Aleti, Arach, Beatrice, Ocung, Emmanuel, Amone, Geoffrey, Miles, Peter, Adong, Claudia, Tumsuiime, Constance, Kidega, Patrick, Otto, Ben, Apio, Florence, Baleeta, Keith, Mukuye, Andrew, Abwola, Mary, Ssennono, Fred, Baliruno, David, Tuhirwe, Stephen, Namisi, Ronald, Kigongo, Fredrick, Kikyonkyo, Dickson, Mushahara, Furaha, Tusiime, Julian, Musiime, Alex, Nankya, Agnes, Atwongyeire, Dickens, Sirikye, Sowal, Myalo, Sula, Noowe, Nelson, Lugemwa, Abbas, Kasozi, Mariam, Mwebe, Sandra, Atwine, Lorna, Senkindu, Tapson, Natuhurira, Ian, Katemba, Chrispus, Ninsiima, Emily, Acaku, Moses, Kyomuhangi, Joy, Ankunda, Rogers, Tukwasibwe, Deogratious, Ayesiga, Lillian, Hakim, James, Nathoo, Kusum, Bwakura-Dangarembizi, Mutsa, Reid, Andrew, Chidziva, Ennie, Mhute, Tawand, Tinago, Gloria, Bhiri, Joyline, Mudzingwa, Shepherd, Phiri, Misheck, Steamer, John, Nhema, Ruth, Warambwa, Colin, Musoro, Godfrey, Mutsai, Shirley, Nemasango, Beauty, Moyo, Columbus, Chitongo, Stuart, Rashirai, Kennias, Vhembo, Sydney, Mlambo, Brian, Nkomani, Sanele, Ndemera, Buxton, Willard, Marko, Berejena, Chipo, Musodza, Yeukai, Matiza, Patience, Mudenge, Boniface, Guti, Vongai, Etyang, Anthony, Agutu, Clara, Berkley, Jay, Maitland, Kathryn, Njuguna, Patricia, Mwaringa, Shalton, Etyang, Timothy, Awuondo, Ken, Wale, Stephen, Shangala, Jimmy, Kithunga, Jefwa, Mwarumba, Salim, Said Maitha, Salma, Mutai, Robert, Lozi Lewa, Margaret, Mwambingu, Gabriel, Mwanzu, Alfred, Kalama, Connie, Latham, Helen, Shikuku, Joyce, Fondo, Amos, Njogu, Anne, Khadenge, Connie, Mwakisha, Bryan, Siika, Abraham, Wools-Kaloustian, Kara, Nyandiko, Winston, Chepkorir-Cheruiyot, Priscilla, Sudoi, Allan, Wachira, Simon, Meli, Betty, Karoney, Mercy, Nzioka, Agnes, Tanui, Michael, Mokaya, Martha, Ekiru, Wilson, Mboya, Chris, Mwimali, Dorothy, Mengich, Cecilia, Choge, Julie, Injera, Wilfred, Njenga, Kennedy, Cherutich, Salinah, Anyango Orido, Millicent, Omondi Lwande, Gerald, Rutto, Peter, Mudogo, Alice, Kutto, Irene, Shali, Amina, Jaika, Linda, Jerotich, Hellen, Pierre, Mowlem, Mallewa, Jane, Kaunda, Symon, Van Oosterhout, Joep, O'Hare, Bernadette, Heydermann, Robert, Gonzalez, Carmen, Dzabala, Nettie, Kelly, Christine, Denis, Brigitte, Selemani, George, Nyondo- Mipando, Linda, Chirwa, Emmie, Banda, Peter, Mvula, Linley, Msuku, Harrison, Ziwoya, Milton, Manda, Yollam, Nicholas, Simon, Masesa, Clemens, Mwalukomo, Thandi, Makhaza, Lumbani, Sheha, Irene, Bwanali, Joseph, Limbuni, Molly, Gibb, Diana M, Thomason, Margaret J, Walker, Ann Sarah, Pett, Sarah L, Szubert, Alexander J, Griffiths, Anna, Wilkes, Helen, Rajapakse, Chathurika, Spyer, Moira J, Prendergast, Andrew J, Klein, Nigel, Rauchenberger, Mary, Van Looy, Nadine, Little, Emma, Fairbrother, Keith, Cowan, Frances, Seeley, Janet, Bernays, Sarah, Kawuma, Rachel, Mupambireyi, Zivai, Chepkorir, Priscilla, Melly, Betty, Walker, A Sarah, and Berkley, James A
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- 2018
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5. Prediction of Outcome From Adult Bacterial Meningitis in a High-HIV-Seroprevalence, Resource-Poor Setting Using the Malawi Adult Meningitis Score (MAMS)
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Wall, Emma C., Mukaka, Mavuto, Scarborough, Matthew, Ajdukiewicz, Katherine M. A., Cartwright, Katharine E., Nyirenda, Mulinda, Denis, Brigitte, Allain, Theresa J., Faragher, Brian, Lalloo, David G., and Heyderman, Robert S.
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- 2017
6. Trends in antimicrobial resistance in bloodstream infection isolates at a large urban hospital in Malawi (1998–2016): a surveillance study
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Musicha, Patrick, Cornick, Jennifer E, Bar-Zeev, Naor, French, Neil, Masesa, Clemens, Denis, Brigitte, Kennedy, Neil, Mallewa, Jane, Gordon, Melita A, Msefula, Chisomo L, Heyderman, Robert S, Everett, Dean B, and Feasey, Nicholas A
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- 2017
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7. Pf7: an open dataset of Plasmodium falciparum genome variation in 20,000 worldwide samples
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Abdel Hamid, Muzamil Mahdi, Abdelraheem, Mohamed Hassan, Acheampong, Desmond Omane, Ahouidi, Ambroise, Ali, Mozam, Almagro-Garcia, Jacob, Amambua-Ngwa, Alfred, Amaratunga, Chanaki, Amenga-Etego, Lucas, Andagalu, Ben, Anderson, Tim, Andrianaranjaka, Voahangy, Aniebo, Ifeyinwa, Aninagyei, Enoch, Ansah, Felix, Ansah, Patrick, Apinjoh, Tobias, Arnaldo, Paulo, Ashley, Elizabeth, Auburn, Sarah, Awandare, Gordon, Ba, Hampate, Baraka, Vito, Barry, Alyssa, Bejon, Philip, Bertin, Gwladys, Boni, Maciej, Borrmann, Steffen, Bousema, Teun, Bouyou-Akotet, Marielle, Branch, Oralee, Bull, Peter, Cheah, Huch, Chindavongsa, Keobouphaphone, Chookajorn, Thanat, Chotivanich, Kesinee, Claessens, Antoine, Conway, David, Corredor, Vladimir, Courtier, Erin, Craig, Alister, d'Alessandro, Umberto, Dama, Souleymane, Day, Nicholas, Denis, Brigitte, Dhorda, Mehul, Diakite, Mahamadou, Djimde, Abdoulaye, Dolecek, Christiane, Dondorp, Arjen, Doumbia, Seydou, Drakeley, Chris, Drury, Eleanor, Duffy, Patrick, Echeverry, Diego, Egwang, Thomas, Enosse, Sonia Maria Mauricio, Erko, Berhanu, Fairhurst, Rick, Faiz, Abdul, Fanello, Caterina, Fleharty, Mark, Forbes, Matthew, Fukuda, Mark, Gamboa, Dionicia, Ghansah, Anita, Golassa, Lemu, Goncalves, Sonia, Harrison, G, Healy, Sara Anne, Hendry, Jason, Hernandez-Koutoucheva, Anastasia, Hien, Tran Tinh, Hill, Catherine, Hombhanje, Francis, Hott, Amanda, Htut, Ye, Hussein, Mazza, Imwong, Mallika, Ishengoma, Deus, Jackson, Scott, Jacob, Chris, Jeans, Julia, Johnson, Kimberly, Kamaliddin, Claire, Kamau, Edwin, Keatley, Jon, Kochakarn, Theerarat, Konate, Drissa, Konaté, Abibatou, Kone, Aminatou, Kwiatkowski, Dominic, Kyaw, Myat, Kyle, Dennis, Lawniczak, Mara, Lee, Samuel, Lemnge, Martha, Lim, Pharath, Lon, Chanthap, Loua, Kovana, Mandara, Celine, Marfurt, Jutta, Marsh, Kevin, Maude, Richard James, Mayxay, Mayfong, Maïga-Ascofaré, Oumou, Miotto, Olivo, Mita, Toshihiro, Mobegi, Victor, Mohamed, Abdelrahim Osman, Mokuolu, Olugbenga, Montgomery, Jaqui, Morang'A, Collins Misita, Mueller, Ivo, Murie, Kathryn, Newton, Paul, Ngo Duc, Thang, Nguyen, Thuy, Nguyen, Thuy-Nhien, Nguyen Thi Kim, Tuyen, Nguyen Van, Hong, Noedl, Harald, Nosten, François, Noviyanti, Rintis, Ntui, Vincent Ntui-Njock, Nzila, Alexis, Ochola-Oyier, Lynette Isabella, Ocholla, Harold, Oduro, Abraham, Omedo, Irene, Onyamboko, Marie, Ouedraogo, Jean-Bosco, Oyebola, Kolapo, Oyibo, Wellington Aghoghovwia, Pearson, Richard, Peshu, Norbert, Phyo, Aung, Plowe, Christopher, Price, Ric, Pukrittayakamee, Sasithon, Quang, Huynh Hong, Randrianarivelojosia, Milijaona, Rayner, Julian, Ringwald, Pascal, Rosanas-Urgell, Anna, Rovira-Vallbona, Eduard, Ruano-Rubio, Valentin, Ruiz, Lastenia, Saunders, David, Shayo, Alex, Siba, Peter, Simpson, Victoria, Sissoko, Mahamadou, Smith, Christen, Su, Xin-Zhuan, Sutherland, Colin, Takala-Harrison, Shannon, Talman, Arthur, Tavul, Livingstone, Thanh, Ngo Viet, Thathy, Vandana, Thu, Aung Myint, Toure, Mahamoudou, Tshefu, Antoinette, Verra, Federica, Vinetz, Joseph, Wellems, Thomas, Wendler, Jason, White, Nicholas, Whitton, Georgia, Yavo, William, van der Pluijm, Rob, MalariaGEN, University of Khartoum, University of Cape Coast [Ghana], Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD), The Wellcome Trust Sanger Institute [Cambridge], London School of Hygiene and Tropical Medicine [Fajara, Gambia], London School of Hygiene and Tropical Medicine (LSHTM), National Institute of Allergy and Infectious Diseases [Bethesda] (NIAID-NIH), National Institutes of Health [Bethesda] (NIH), West African Centre for Cell Biology of Infectious Pathogens [Legon, Ghana] (WACCBIP), University of Ghana, Navrongo Health Research Centre [Navrongo, Ghana] (NHRC), Kenya Medical Research Institute (KEMRI), Texas Biomedical Research Institute [San Antonio, TX], Université d'Antananarivo, University of Buéa, Instituto Nacional de Saude [Maputo, Mozambique] (INS), Centre for Tropical Medicine and Global Health [Oxford, UK], Nuffield Department of Medicine [Oxford, UK] (Big Data Institute), University of Oxford-University of Oxford, Mahidol Oxford Tropical Medicine Research Unit (MORU), University of Oxford-Mahidol University [Bangkok]-Wellcome Trust, Menzies School of Health Research [Australia], Charles Darwin University [Australia], Nuffield Department of Clinical Medicine [Oxford], University of Oxford, Institut de Recherche pour le Développement (IRD), Laboratory of Pathogen and Host Immunity [Montpellier] (LPHI), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), and Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)
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data resource ,lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] ,plasmodium falciparum ,genomics ,malaria ,Medicine (miscellaneous) ,genomic epidemiology ,General Biochemistry, Genetics and Molecular Biology ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
Contains fulltext : 291985.pdf (Publisher’s version ) (Open Access) We describe the MalariaGEN Pf7 data resource, the seventh release of Plasmodium falciparum genome variation data from the MalariaGEN network. It comprises over 20,000 samples from 82 partner studies in 33 countries, including several malaria endemic regions that were previously underrepresented. For the first time we include dried blood spot samples that were sequenced after selective whole genome amplification, necessitating new methods to genotype copy number variations. We identify a large number of newly emerging crt mutations in parts of Southeast Asia, and show examples of heterogeneities in patterns of drug resistance within Africa and within the Indian subcontinent. We describe the profile of variations in the C-terminal of the csp gene and relate this to the sequence used in the RTS,S and R21 malaria vaccines. Pf7 provides high-quality data on genotype calls for 6 million SNPs and short indels, analysis of large deletions that cause failure of rapid diagnostic tests, and systematic characterisation of six major drug resistance loci, all of which can be freely downloaded from the MalariaGEN website.
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- 2023
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- View/download PDF
8. Feelings of Telepresence and Proximity: the Perspectives of E-tutors on a Hybrid Learning Environment
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Denis, Brigitte, primary
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- 2018
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- View/download PDF
9. Pf7: an open dataset of Plasmodium falciparum genome variation in 20,000 worldwide samples
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MalariaGEN, Abdel Hamid, Muzamil Mahdi, Abdelraheem, Mohamed Hassan, Acheampong, Desmond Omane, Ahouidi, Ambroise, Ali, Mozam, Almagro-Garcia, Jacob, Amambua-Ngwa, Alfred, Amaratunga, Chanaki, Amenga-Etego, Lucas, Andagalu, Ben, Anderson, Tim, Andrianaranjaka, Voahangy, Aniebo, Ifeyinwa, Aninagyei, Enoch, Ansah, Felix, Ansah, Patrick O, Apinjoh, Tobias, Arnaldo, Paulo, Ashley, Elizabeth, Auburn, Sarah, Awandare, Gordon A, Ba, Hampate, Baraka, Vito, Barry, Alyssa, Bejon, Philip, Bertin, Gwladys I, Boni, Maciej F, Borrmann, Steffen, Bousema, Teun, Bouyou-Akotet, Marielle, Branch, Oralee, Bull, Peter C, Cheah, Huch, Chindavongsa, Keobouphaphone, Chookajorn, Thanat, Chotivanich, Kesinee, Claessens, Antoine, Conway, David J, Corredor, Vladimir, Courtier, Erin, Craig, Alister, D'Alessandro, Umberto, Dama, Souleymane, Day, Nicholas, Denis, Brigitte, Dhorda, Mehul, Diakite, Mahamadou, Djimde, Abdoulaye, Dolecek, Christiane, Dondorp, Arjen, Doumbia, Seydou, Drakeley, Chris, Drury, Eleanor, Duffy, Patrick, Echeverry, Diego F, Egwang, Thomas G, Enosse, Sonia Maria Mauricio, Erko, Berhanu, Fairhurst, Rick M, Faiz, Abdul, Fanello, Caterina A, Fleharty, Mark, Forbes, Matthew, Fukuda, Mark, Gamboa, Dionicia, Ghansah, Anita, Golassa, Lemu, Goncalves, Sonia, Harrison, GL Abby, Healy, Sara Anne, Hendry, Jason A, Hernandez-Koutoucheva, Anastasia, Hien, Tran Tinh, Hill, Catherine A, Hombhanje, Francis, Hott, Amanda, Htut, Ye, Hussein, Mazza, Imwong, Mallika, Ishengoma, Deus, Jackson, Scott A, Jacob, Chris G, Jeans, Julia, Johnson, Kimberly J, Kamaliddin, Claire, Kamau, Edwin, Keatley, Jon, Kochakarn, Theerarat, Konate, Drissa S, Konaté, Abibatou, Kone, Aminatou, Kwiatkowski, Dominic P, Kyaw, Myat P, Kyle, Dennis, Lawniczak, Mara, Lee, Samuel K, Lemnge, Martha, Lim, Pharath, Lon, Chanthap, Loua, Kovana M, Mandara, Celine I, Marfurt, Jutta, Marsh, Kevin, Maude, Richard James, Mayxay, Mayfong, Maïga-Ascofaré, Oumou, Miotto, Olivo, Mita, Toshihiro, Mobegi, Victor, Mohamed, Abdelrahim Osman, Mokuolu, Olugbenga A, Montgomery, Jaqui, Morang'a, Collins Misita, Mueller, Ivo, Murie, Kathryn, Newton, Paul N, Ngo Duc, Thang, Nguyen, Thuy, Nguyen, Thuy-Nhien, Nguyen Thi Kim, Tuyen, Nguyen Van, Hong, Noedl, Harald, Nosten, Francois, Noviyanti, Rintis, Ntui, Vincent Ntui-Njock, Nzila, Alexis, Ochola-Oyier, Lynette Isabella, Ocholla, Harold, Oduro, Abraham, Omedo, Irene, Onyamboko, Marie A, Ouedraogo, Jean-Bosco, Oyebola, Kolapo, Oyibo, Wellington Aghoghovwia, Pearson, Richard, Peshu, Norbert, Phyo, Aung P, Plowe, Christopher V, Price, Ric N, Pukrittayakamee, Sasithon, Quang, Huynh Hong, Randrianarivelojosia, Milijaona, Rayner, Julian C, Ringwald, Pascal, Rosanas-Urgell, Anna, Rovira-Vallbona, Eduard, Ruano-Rubio, Valentin, Ruiz, Lastenia, Saunders, David, Shayo, Alex, Siba, Peter, Simpson, Victoria J, Sissoko, Mahamadou S, Smith, Christen, Su, Xin-Zhuan, Sutherland, Colin, Takala-Harrison, Shannon, Talman, Arthur, Tavul, Livingstone, Thanh, Ngo Viet, Thathy, Vandana, Thu, Aung Myint, Toure, Mahamoudou, Tshefu, Antoinette, Verra, Federica, Vinetz, Joseph, Wellems, Thomas E, Wendler, Jason, White, Nicholas J, Whitton, Georgia, Yavo, William, Van Der Pluijm, Rob W, Amenga-Etego, Lucas [0000-0003-4468-0506], Anderson, Tim [0000-0002-0191-0204], Ansah, Patrick O [0000-0002-3214-5621], Ashley, Elizabeth [0000-0002-7620-4822], Ba, Hampate [0000-0002-9299-5775], Baraka, Vito [0000-0001-9694-9293], Bejon, Philip [0000-0002-2135-7549], Bertin, Gwladys I [0000-0002-2218-9591], Boni, Maciej F [0000-0002-0830-9630], Bousema, Teun [0000-0003-2666-094X], Chookajorn, Thanat [0000-0003-2876-6203], Claessens, Antoine [0000-0002-4277-0914], Conway, David J [0000-0002-8711-3037], Craig, Alister [0000-0003-0914-6164], D'Alessandro, Umberto [0000-0001-6341-5009], Day, Nicholas [0000-0003-2309-1171], Diakite, Mahamadou [0000-0002-4268-8857], Djimde, Abdoulaye [0000-0003-0062-2283], Dondorp, Arjen [0000-0001-5190-2395], Drakeley, Chris [0000-0003-4863-075X], Echeverry, Diego F [0000-0003-0301-4478], Erko, Berhanu [0000-0003-1685-752X], Faiz, Abdul [0000-0002-3460-7535], Fanello, Caterina A [0000-0003-1932-9562], Gamboa, Dionicia [0000-0002-1420-7729], Golassa, Lemu [0000-0002-1216-8711], Healy, Sara Anne [0000-0003-3078-6094], Ishengoma, Deus [0000-0003-2040-3416], Jackson, Scott A [0000-0002-3172-1607], Kamaliddin, Claire [0000-0001-8198-6235], Kamau, Edwin [0000-0002-5761-7883], Konate, Drissa S [0000-0002-4177-9642], Kwiatkowski, Dominic P [0000-0002-5023-0176], Kyle, Dennis [0000-0002-0238-965X], Lawniczak, Mara [0000-0002-3006-2080], Loua, Kovana M [0000-0003-0571-0944], Marsh, Kevin [0000-0001-8377-5466], Mayxay, Mayfong [0000-0002-6056-4516], Miotto, Olivo [0000-0001-8060-6771], Mita, Toshihiro [0000-0001-8180-2344], Mobegi, Victor [0000-0002-1962-5583], Morang'a, Collins Misita [0000-0002-6988-150X], Nguyen, Thuy-Nhien [0000-0002-4101-5706], Nosten, Francois [0000-0002-7951-0745], Ntui, Vincent Ntui-Njock [0000-0002-7532-9930], Oduro, Abraham [0000-0002-4191-7419], Onyamboko, Marie A [0000-0002-7501-5931], Ouedraogo, Jean-Bosco [0000-0003-0412-8733], Oyebola, Kolapo [0000-0002-1003-2570], Pearson, Richard [0000-0002-7386-3566], Phyo, Aung P [0000-0002-0383-9624], Price, Ric N [0000-0003-2000-2874], Rayner, Julian C [0000-0002-9835-1014], Rosanas-Urgell, Anna [0000-0002-0432-5203], Shayo, Alex [0000-0002-7099-8537], Su, Xin-Zhuan [0000-0003-3246-3248], Vinetz, Joseph [0000-0001-8344-2004], Wellems, Thomas E [0000-0003-3899-8454], and Apollo - University of Cambridge Repository
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data resource ,plasmodium falciparum ,genomics ,malaria ,genomic epidemiology - Abstract
We describe the MalariaGEN Pf7 data resource, the seventh release of Plasmodium falciparum genome variation data from the MalariaGEN network. It comprises over 20,000 samples from 82 partner studies in 33 countries, including several malaria endemic regions that were previously underrepresented. For the first time we include dried blood spot samples that were sequenced after selective whole genome amplification, necessitating new methods to genotype copy number variations. We identify a large number of newly emerging crt mutations in parts of Southeast Asia, and show examples of heterogeneities in patterns of drug resistance within Africa and within the Indian subcontinent. We describe the profile of variations in the C-terminal of the csp gene and relate this to the sequence used in the RTS,S and R21 malaria vaccines. Pf7 provides high-quality data on genotype calls for 6 million SNPs and short indels, analysis of large deletions that cause failure of rapid diagnostic tests, and systematic characterisation of six major drug resistance loci, all of which can be freely downloaded from the MalariaGEN website.
- Published
- 2023
10. Mathematical Modeling to Assess the Drivers of the Recent Emergence of Typhoid Fever in Blantyre, Malawi
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Pitzer, Virginia E., Feasey, Nicholas A., Msefula, Chisomo, Mallewa, Jane, Kennedy, Neil, Dube, Queen, Denis, Brigitte, Gordon, Melita A., and Heyderman, Robert S.
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- 2015
11. Effect of resistance to third-generation cephalosporins on morbidity and mortality from bloodstream infections in Blantyre, Malawi: a prospective cohort study
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Lester, Rebecca, primary, Musicha, Patrick, additional, Kawaza, Kondwani, additional, Langton, Josephine, additional, Mango, James, additional, Mangochi, Helen, additional, Bakali, Winnie, additional, Pearse, Oliver, additional, Mallewa, Jane, additional, Denis, Brigitte, additional, Bilima, Sithembile, additional, Gordon, Stephen B, additional, Lalloo, David G, additional, Jewell, Christopher P, additional, and Feasey, Nicholas A, additional
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- 2022
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12. Targeted Transcriptomic Screen of Pneumococcal Genes Expressed during Murine and Human Infection
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Basset, Alan, primary, Wall, Emma, additional, Mitsi, Elena, additional, Deshusses, Chloe, additional, Daly, Raecliffe, additional, Pojar, Sherin, additional, Reiné, Jesús, additional, Guerra-Assuncao, Jose Afonso, additional, Denis, Brigitte, additional, Jochems, Simon P., additional, Heyderman, Robert, additional, Brown, Jeremy, additional, Lu, Ying-Jie, additional, Ferreira, Daniela M., additional, and Malley, Richard, additional
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- 2022
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13. Measuring some Cognitive Effects of Using Control Technology
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Denis, Brigitte and Denis, Brigitte, editor
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- 1993
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14. Regulation of training systems for adults in educational technology
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Denis, Brigitte, Piette, Sylvie-Anne, Davies, Gordon, editor, and Stacey, Elizabeth, editor
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- 2003
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15. Effect of resistance to third-generation cephalosporins on morbidity and mortality from bloodstream infections in Blantyre, Malawi:a prospective cohort study
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Lester, Rebecca, Musicha, Patrick, Kawaza, Kondwani, Langton, Josephine, Mango, James, Mangochi, Helen, Bakali, Winnie, Pearse, Oliver, Mallewa, Jane, Denis, Brigitte, Bilima, Sithembile, Gordon, Stephen B, Lalloo, David G, Jewell, Christopher P, Feasey, Nicholas A, Lester, Rebecca, Musicha, Patrick, Kawaza, Kondwani, Langton, Josephine, Mango, James, Mangochi, Helen, Bakali, Winnie, Pearse, Oliver, Mallewa, Jane, Denis, Brigitte, Bilima, Sithembile, Gordon, Stephen B, Lalloo, David G, Jewell, Christopher P, and Feasey, Nicholas A
- Abstract
Background: The burden of antimicrobial resistance is a major threat to global health; however, prospective clinical outcome data from Africa are scarce. In Malawi, third-generation cephalosporins are the antibiotics of choice in patients admitted to hospital despite a rapid proliferation of resistance to these drugs. We aimed to quantify the effect of resistance to third-generation cephalosporins on mortality and length of hospital stay among patients with bloodstream infections. Methods: We did a prospective cohort study of patients admitted to Queen Elizabeth Central Hospital in Blantyre, Malawi. Patients of all ages who had positive blood cultures for Enterobacterales were included, with the exception of those from the genus Salmonella, and were followed up for 180 days. We characterised blood culture isolates using whole-genome sequencing and used Cox regression models to estimate the effect of resistance to third-generation cephalosporins on length of hospital stay, in-hospital mortality, and survival. Findings: Between Jan 31, 2018, and Jan 13, 2020, we recruited 326 patients, from whom 220 (68%) of 326 isolates were resistant to third-generation cephalosporins. The case fatality proportion was 45% (99 of 220) in patients with bloodstream infections that were resistant to third-generation cephalosporins, and 34% (36 of 106) in patients with bloodstream infections that were sensitive to third-generation cephalosporins. Resistance to third-generation cephalosporins was associated with an increased probability of in-hospital mortality (hazard ratio [HR] 1·44, 95% CI 1·02–2·04), longer hospital stays (1·5 days, 1·0–2·0) and decreased probability of discharge alive (HR 0·31, 0·22–0·45). Whole-genome sequencing showed a high diversity of sequence types of both Escherichia coli and Klebsiella pneumoniae. Although isolates associated with death were distributed across clades, we identified three E coli clades (ST410, ST617, and ST648) that were isolated from 14 patie
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- 2022
16. Incidence of invasive non-typhoidal Salmonella in Blantyre, Malawi between January 2011-December 2019
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Wilson, Catherine N., primary, Chunga, Angeziwa, additional, Masesa, Clemens, additional, Denis, Brigitte, additional, Silungwe, Niza, additional, Bilima, Sithembile, additional, Galloway, Heather, additional, Gordon, Melita, additional, and Feasey, Nicholas A., additional
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- 2022
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17. Distinct clinical and immunological profiles of patients with evidence of SARS-CoV-2 infection in sub-Saharan Africa
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Morton, Ben, Barnes, Kayla G., Anscombe, Catherine, Jere, Khuzwayo, Matambo, Prisca, Mandolo, Jonathan, Kamng’ona, Raphael, Brown, Comfort, Nyirenda, James, Phiri, Tamara, Banda, Ndaziona P., Van Der Veer, Charlotte, Mndolo, Kwazizira S., Mponda, Kelvin, Rylance, Jamie, Phiri, Chimota, Mallewa, Jane, Nyirenda, Mulinda, Katha, Grace, Kambiya, Paul, Jafali, James, Mwandumba, Henry C., Gordon, Stephen B., Cornick, Jennifer, Jambo, Kondwani C., Phulusa, Jacob, Mkandawire, Mercy, Kaimba, Sylvester, Thole, Herbert, Nthala, Sharon, Nsomba, Edna, Keyala, Lucy, Mandala, Peter, Chinoko, Beatrice, Gmeiner, Markus, Kaudzu, Vella, Lissauer, Samantha, Freyne, Bridget, MacPherson, Peter, Swarthout, Todd D., Iroh Tam, Pui-Ying, Sichone, Simon, Ahmadu, Ajisa, Kanjewa, Oscar, Nyasulu, Vita, Chinyama, End, Zuza, Allan, Denis, Brigitte, Storey, Evance, Bondera, Nedson, Matchado, Danford, Chande, Adams, Chingota, Arthur, Ntwea, Chimenya, Mkandawire, Langford, Mhango, Chimwemwe, Lakudzala, Agness, Chaponda, Mphatso, Mwenechanya, Percy, Mvaya, Leonard, Tembo, Dumizulu, Henrion, Marc Y. R., Chirombo, James, Masesa, Clemens, and Gondwe, Joel
- Subjects
wa_105 ,qw_568 ,mental disorders ,wc_505 ,qw_160 ,wa_395 - Abstract
Although the COVID-19 pandemic has left no country untouched there has been limited research to understand clinical and immunological responses in African populations. Here we characterise patients hospitalised with suspected (PCR-negative/IgG-positive) or confirmed (PCR-positive) COVID-19, and healthy community controls (PCR-negative/IgG-negative). PCR-positive COVID-19 participants were more likely to receive dexamethasone and a beta-lactam antibiotic, and survive to hospital discharge than PCR-negative/IgG-positive and PCR-negative/IgG-negative participants. PCR-negative/IgG-positive participants exhibited a nasal and systemic cytokine signature analogous to PCR-positive COVID-19 participants, predominated by chemokines and neutrophils and distinct from PCR-negative/IgG-negative participants. PCR-negative/IgG-positive participants had increased propensity for Staphylococcus aureus and Streptococcus pneumoniae colonisation. PCR-negative/IgG-positive individuals with high COVID-19 clinical suspicion had inflammatory profiles analogous to PCR-confirmed disease and potentially represent a target population for COVID-19 treatment strategies.
- Published
- 2021
18. Human melioidosis, Malawi, 2011
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Katangwe, Thembi, Purcell, Janet, Bar-Zeev, Naor, Denis, Brigitte, Montgomery, Jacqui, Alaerts, Maaike, Heyderman, Robert Simon, Dance, David A.B., Kennedy, Neil, Feasey, Nicholas, and Moxon, Christopher Alan
- Subjects
Pseudomonas infections -- Case studies -- Diagnosis -- Causes of -- Care and treatment ,Health - Abstract
Melioidosis is widely distributed in tropical and subtropical regions, but data are lacking on this disease in sub-Saharan Africa. We report a case of melioidosis caused by a novel sequence [...]
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- 2013
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19. Changing incidence of invasive pneumococcal disease in infants less than 90 days of age before and after introduction of the 13-valent Pneumococcal Conjugate Vaccine in Blantyre, Malawi: a 14-year hospital based surveillance study
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Koenraads, Marianne, primary, Swarthout, Todd D., additional, Bar-Zeev, Naor, additional, Brown, Comfort, additional, Msefula, Jacquline, additional, Denis, Brigitte, additional, Dube, Queen, additional, Gordon, Stephen B., additional, Heyderman, Robert S., additional, Gladstone, Melissa, additional, and French, Neil, additional
- Published
- 2021
- Full Text
- View/download PDF
20. An open dataset of Plasmodium falciparum genome variation in 7,000 worldwide samples
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Ahouidi, Ambroise, Ali, Mozam, Almagro-Garcia, Jacob, Amambua-Ngwa, Alfred, Amaratunga, Chanaki, Amato, Roberto, Amenga-Etego, Lucas, Andagalu, Ben, Anderson, Tim JC, Andrianaranjaka, Voahangy, Apinjoh, Tobias, Ariani, Cristina, Ashley, Elizabeth A, Auburn, Sarah, Awandare, Gordon, Ba, Hampdate, Baraka, Vito, Barry, Alyssa E, Bejon, Philip, Bertin, Gwladys I, Boni, Maciej F, Borrmann, Steffen, Bousema, Teun, Branch, Oralee, Bull, Peter C, Busby, George BJ, Chookajorn, Thanat, Chotivanich, Kesinee, Claessens, Antoine, Conway, David, Craig, Alister, D'Alessandro, Umberto, Dama, Souleymane, Day, Nicholas PJ, Denis, Brigitte, Diakite, Mahamadou, Djimdé, Abdoulaye, Dolecek, Christiane, Dondorp, Arjen M, Drakeley, Chris, Drury, Eleanor, Duffy, Patrick, Echeverry, Diego F, Egwang, Thomas G, Erko, Berhanu, Fairhurst, Rick M, Faiz, Abdul, Fanello, Caterina A, Fukuda, Mark M, Gamboa, Dionica, Ghansah, Anita, Golassa, Lemu, Goncalves, Sonia, Hamilton, William L, Harrison, GL Abby, Hart, Lee, Henrichs, Christa, Hien, Tran Tinh, Hill, Catherine A, Hodgson, Abraham, Hubbart, Christina, Imwong, Mallika, Ishengoma, Deus S, Jackson, Scott A, Jacob, Chris G, Jeffery, Ben, Jeffreys, Anna E, Johnson, Kimberly J, Jyothi, Dushyanth, Kamaliddin, Claire, Kamau, Edwin, Kekre, Mihir, Kluczynski, Krzysztof, Kochakarn, Theerarat, Konaté, Abibatou, Kwiatkowski, Dominic P, Kyaw, Myat Phone, Lim, Pharath, Lon, Chanthap, Loua, Kovana M, Maïga-Ascofaré, Oumou, Malangone, Cinzia, Manske, Magnus, Marfurt, Jutta, Marsh, Kevin, Mayxay, Mayfong, Miles, Alistair, Miotto, Olivo, Mobegi, Victor, Mokuolu, Olugbenga A, Montgomery, Jacqui, Mueller, Ivo, Newton, Paul N, Nguyen, Thuy, Nguyen, Thuy-Nhien, Noedl, Harald, Nosten, Francois, Noviyanti, Rintis, Nzila, Alexis, Ochola-Oyier, Lynette I, Ahouidi, Ambroise, Ali, Mozam, Almagro-Garcia, Jacob, Amambua-Ngwa, Alfred, Amaratunga, Chanaki, Amato, Roberto, Amenga-Etego, Lucas, Andagalu, Ben, Anderson, Tim JC, Andrianaranjaka, Voahangy, Apinjoh, Tobias, Ariani, Cristina, Ashley, Elizabeth A, Auburn, Sarah, Awandare, Gordon, Ba, Hampdate, Baraka, Vito, Barry, Alyssa E, Bejon, Philip, Bertin, Gwladys I, Boni, Maciej F, Borrmann, Steffen, Bousema, Teun, Branch, Oralee, Bull, Peter C, Busby, George BJ, Chookajorn, Thanat, Chotivanich, Kesinee, Claessens, Antoine, Conway, David, Craig, Alister, D'Alessandro, Umberto, Dama, Souleymane, Day, Nicholas PJ, Denis, Brigitte, Diakite, Mahamadou, Djimdé, Abdoulaye, Dolecek, Christiane, Dondorp, Arjen M, Drakeley, Chris, Drury, Eleanor, Duffy, Patrick, Echeverry, Diego F, Egwang, Thomas G, Erko, Berhanu, Fairhurst, Rick M, Faiz, Abdul, Fanello, Caterina A, Fukuda, Mark M, Gamboa, Dionica, Ghansah, Anita, Golassa, Lemu, Goncalves, Sonia, Hamilton, William L, Harrison, GL Abby, Hart, Lee, Henrichs, Christa, Hien, Tran Tinh, Hill, Catherine A, Hodgson, Abraham, Hubbart, Christina, Imwong, Mallika, Ishengoma, Deus S, Jackson, Scott A, Jacob, Chris G, Jeffery, Ben, Jeffreys, Anna E, Johnson, Kimberly J, Jyothi, Dushyanth, Kamaliddin, Claire, Kamau, Edwin, Kekre, Mihir, Kluczynski, Krzysztof, Kochakarn, Theerarat, Konaté, Abibatou, Kwiatkowski, Dominic P, Kyaw, Myat Phone, Lim, Pharath, Lon, Chanthap, Loua, Kovana M, Maïga-Ascofaré, Oumou, Malangone, Cinzia, Manske, Magnus, Marfurt, Jutta, Marsh, Kevin, Mayxay, Mayfong, Miles, Alistair, Miotto, Olivo, Mobegi, Victor, Mokuolu, Olugbenga A, Montgomery, Jacqui, Mueller, Ivo, Newton, Paul N, Nguyen, Thuy, Nguyen, Thuy-Nhien, Noedl, Harald, Nosten, Francois, Noviyanti, Rintis, Nzila, Alexis, and Ochola-Oyier, Lynette I
- Abstract
MalariaGEN is a data-sharing network that enables groups around the world to work together on the genomic epidemiology of malaria. Here we describe a new release of curated genome variation data on 7,000 Plasmodium falciparum samples from MalariaGEN partner studies in 28 malaria-endemic countries. High-quality genotype calls on 3 million single nucleotide polymorphisms (SNPs) and short indels were produced using a standardised analysis pipeline. Copy number variants associated with drug resistance and structural variants that cause failure of rapid diagnostic tests were also analysed. Almost all samples showed genetic evidence of resistance to at least one antimalarial drug, and some samples from Southeast Asia carried markers of resistance to six commonly-used drugs. Genes expressed during the mosquito stage of the parasite life-cycle are prominent among loci that show strong geographic differentiation. By continuing to enlarge this open data resource we aim to facilitate research into the evolutionary processes affecting malaria control and to accelerate development of the surveillance toolkit required for malaria elimination.
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- 2021
21. PIAF: Developing Computational and Algorithmic Thinking in Fundamental Education
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Parmentier, Yannick, Reuter, Robert, Higuet, Sarah, Kataja, Lara, Kreis, Yves, Duflot-Kremer, Marie, Laduron, Christophe, Meyers, Christian, Busana, Gilbert, Weinberger, Armin, Denis, Brigitte, Natural Language Processing : representations, inference and semantics (SYNALP), Department of Natural Language Processing & Knowledge Discovery (LORIA - NLPKD), Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Informatique Fondamentale d'Orléans (LIFO), Université d'Orléans (UO)-Institut National des Sciences Appliquées - Centre Val de Loire (INSA CVL), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), University of Luxembourg [Luxembourg], Université de Liège, Universität des Saarlandes [Saarbrücken], Modeling and Verification of Distributed Algorithms and Systems (VERIDIS), Department of Formal Methods (LORIA - FM), Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Inria Nancy - Grand Est, Institut National de Recherche en Informatique et en Automatique (Inria)-Max-Planck-Institut für Informatik (MPII), Max-Planck-Gesellschaft-Max-Planck-Gesellschaft, Proof-oriented development of computer-based systems (MOSEL), Max-Planck-Institut für Informatik (MPII), Max-Planck-Gesellschaft-Max-Planck-Gesellschaft-Inria Nancy - Grand Est, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Department of Formal Methods (LORIA - FM), and Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)
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computational thinking ,[INFO.INFO-CY]Computer Science [cs]/Computers and Society [cs.CY] ,[SHS.EDU]Humanities and Social Sciences/Education ,Education & instruction [H04] [Social & behavioral sciences, psychology] ,ComputingMilieux_COMPUTERSANDEDUCATION ,curriculum design ,Education & enseignement [H04] [Sciences sociales & comportementales, psychologie] ,[SCCO.COMP]Cognitive science/Computer science ,fundamental education - Abstract
Full text available at http://www.learntechlib.org/p/217317/; International audience; In this article, we present the objectives and first achievements of the PIAF project supported by the European Union and aiming at developing computational and algorithmic thinking in basic education. This project brings together researchers in educational sciences and computer science from four countries (Belgium, France, Germany and Luxembourg) around the theme of teacher training. More concretely, the aim is to define a framework (competency framework, pedagogical scenarios) enabling teachers to (i) appropriate the concept of computational and algorithmic thinking and (ii) implement learning activities that promote the development of this kind of thinking in children.
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- 2020
22. PIAF : développer la Pensée Informatique et Algorithmique dans l'enseignement Fondamental
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Busana, Gilbert, Denis, Brigitte, Duflot-Kremer, Marie, Higuet, Sarah, Kataja, Lara, Kreis, Yves, Laduron, Christophe, Meyers, Christian, Parmentier, Yannick, Reuter, Robert, Weinberger, Armin, Busana, Gilbert, Denis, Brigitte, Duflot-Kremer, Marie, Higuet, Sarah, Kataja, Lara, Kreis, Yves, Laduron, Christophe, Meyers, Christian, Parmentier, Yannick, Reuter, Robert, and Weinberger, Armin
- Abstract
Dans cet article, nous présentons les objectifs et premières réalisations du projet PIAF soutenu par l’Union Européenne et visant à développer l’apprentissage de la pensée informatique et algorithmique dans l’enseignement fondamental. Ce projet rassemble des chercheur·e·s en sciences de l’éducation et en informatique, provenant de quatre pays (Allemagne, Belgique, France et Luxembourg), autour du thème de la formation des enseignant·e·s. Plus concrètement, il s’agit de définir un cadre (référentiel de compétences, scénarios pédagogiques) permettant aux enseignant·e·s de (i) s’approprier le concept de pensée informatique et algorithmique et de (ii) mettre en œuvre des activités d’apprentissage favorisant le développement de cette pensée chez l’enfant.
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- 2020
23. Collaborative learning in an educational robotics environment
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Denis, Brigitte and Hubert, Sylviane
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Team learning approach in education -- Research ,Educational evaluation -- Methods ,Constructivism (Education) -- Analysis ,Educational technology -- Evaluation ,Robotics -- Study and teaching ,Computer-assisted instruction -- Evaluation ,Computers ,Psychology and mental health ,Sociology and social work - Abstract
Research presents an instructional design to aid collaborative learning in the field of robotics, focusing on how students can acquire specific skills relating to robotics. Topics include the dynamics of group work, constructivism in education, the use of educational technology, and problem-based learning.
- Published
- 2001
24. CSF Levels of Elongation Factor Tu Is Associated With Increased Mortality in Malawian Adults With Streptococcus pneumoniae Meningitis
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Wall, Emma C., primary, Brownridge, Philip, additional, Laing, Gavin, additional, Terra, Vanessa S., additional, Mlozowa, Veronica, additional, Denis, Brigitte, additional, Nyirenda, Mulinda, additional, Allain, Theresa, additional, Ramos-Sevillano, Elisa, additional, Carrol, Enitan, additional, Collins, Andrea, additional, Gordon, Stephen B., additional, Lalloo, David G., additional, Wren, Brendan, additional, Beynon, Robert, additional, Heyderman, Robert S., additional, and Brown, Jeremy S., additional
- Published
- 2020
- Full Text
- View/download PDF
25. CHAPITRE 1. Articuler théories et pratiques en technologie de l'éducation
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Denis, Brigitte, primary
- Published
- 2007
- Full Text
- View/download PDF
26. PIAF : développer la Pensée Informatique et Algorithmique dans l'enseignement Fondamental
- Author
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Busana, Gilbert, Denis, Brigitte, Duflot-Kremer, Marie, Higuet, Sarah, Kataja, Lara, Kreis, Yves, Laduron, Christophe, Meyers, Christian, Parmentier, Yannick, Reuter, Robert, Weinberger, Armin, University of Luxembourg [Luxembourg], Université de Liège, Modeling and Verification of Distributed Algorithms and Systems (VERIDIS), Max-Planck-Institut für Informatik (MPII), Max-Planck-Gesellschaft-Max-Planck-Gesellschaft-Inria Nancy - Grand Est, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Department of Formal Methods (LORIA - FM), Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Universität des Saarlandes [Saarbrücken], Laboratoire d'Informatique Fondamentale d'Orléans (LIFO), Université d'Orléans (UO)-Institut National des Sciences Appliquées - Centre Val de Loire (INSA CVL), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), Natural Language Processing : representations, inference and semantics (SYNALP), Department of Natural Language Processing & Knowledge Discovery (LORIA - NLPKD), Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Travail financé par le programme Erasmus+ de la Comission Européenne, via le projet 2018-1-BE01-KA201-038611 (PIAF), Department of Formal Methods (LORIA - FM), Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Inria Nancy - Grand Est, Institut National de Recherche en Informatique et en Automatique (Inria)-Max-Planck-Institut für Informatik (MPII), Max-Planck-Gesellschaft-Max-Planck-Gesellschaft, and Proof-oriented development of computer-based systems (MOSEL)
- Subjects
[INFO.INFO-CY]Computer Science [cs]/Computers and Society [cs.CY] ,école primaire ,[SHS.EDU]Humanities and Social Sciences/Education ,[INFO.INFO-OH]Computer Science [cs]/Other [cs.OH] ,[INFO.EIAH]Computer Science [cs]/Technology for Human Learning ,scénario pédagogique ,algorithmique ,enseignement fondamental ,[INFO.INFO-CL]Computer Science [cs]/Computation and Language [cs.CL] ,pensée informatique - Abstract
Version étendue d'un article présenté au colloque Didapro8.; Dans cet article, nous présentons les objectifs et premières réalisations du projet PIAF soutenu par l'Union Européenne et visant à développer l'apprentissage de la pensée informatique et algorithmique dans l'enseignement fondamental. Ce projet rassemble des chercheur·e·s en sciences de l'éducation et en informatique, provenant de quatre pays (Allemagne, Belgique, France et Luxembourg), autour du thème de la formation des enseignant·e·s. Plus concrètement, il s'agit de dénir un cadre (référentiel de compétences, scénarios pédagogiques) permettant aux enseignant·e·s de (i) s'approprier le concept de pensée informatique et algorithmique et de (ii) mettre en ÷uvre des activités d'apprentissage favorisant le développement de cette pensée chez l'enfant.
- Published
- 2019
27. Chapitre 9. Les campus virtuels : des «instruments» en évolution
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Denis, Brigitte, primary
- Published
- 2002
- Full Text
- View/download PDF
28. Invasive Streptococcus pneumoniae in Children, Malawi, 2004-2006
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Cornick, Jennifer E., Everett, Dean B., Broughton, Caroline, Denis, Brigitte B., Banda, Daniel L., Carrol, Enitan D., and Parry, Christopher M.
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Nucleic acids -- Separation ,Drug resistance in microorganisms -- Genetic aspects ,Pneumonia, Pneumococcal -- Genetic aspects -- Drug therapy ,Pneumonia in children -- Genetic aspects -- Drug therapy ,Health - Abstract
Streptococcus pneumoniae causes a spectrum of disease, ranging from relatively mild otitis media to life-threatening pneumonia, meningitis, and septicemia. Recent estimates suggest that pneumococcal disease is responsible for 1 million [...]
- Published
- 2011
- Full Text
- View/download PDF
29. Novel biomarker combination improves the diagnosis of serious bacterial infections in Malawian children
- Author
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Irwin Adam D, Marriage Fiona, Mankhambo Limangeni A, Group IPD, Jeffers Graham, Kolamunnage-Dona Ruwanthi, Guiver Malcolm, Denis Brigitte, Molyneux Elizabeth M, Molyneux Malcolm E, Day Philip J, and Carrol Enitan D
- Subjects
Biomarker ,Bacterial infection ,Transcriptomics ,Diagnosis ,Protein ,Biology ,Procalcitonin ,Resistin ,Neutrophil-associated gelatinase ,Internal medicine ,RC31-1245 ,Genetics ,QH426-470 - Abstract
Abstract Background High throughput technologies offer insight into disease processes and heightens opportunities for improved diagnostics. Using transcriptomic analyses, we aimed to discover and to evaluate the clinical validity of a combination of reliable and functionally important biomarkers of serious bacterial infection (SBI). Methods We identified three previously reported biomarkers of infection (neutrophil gelatinase-associated lipocalin (NGAL), granulysin and resistin) and measured gene expression using quantitative real-time PCR. Protein products related to the three transcripts were measured by immunoassays. Results Relative gene expression values of NGAL and resistin were significantly increased, and expression of granulysin significantly decreased in cases compared to controls. Plasma concentrations of NGAL and resistin were significantly increased in children with confirmed SBI compared to children with no detectable bacterial infection (NBI), and to controls (287 versus 128 versus 62 ng/ml and 195 versus 90 versus 18 ng/ml, respectively, p Conclusions We have demonstrated a unique combination of diagnostic biomarkers of SBI using transcriptomics, and demonstrated translational concordance with the corresponding protein. The addition of NGAL and resistin protein measurement to procalcitonin significantly improved the diagnosis of SBI.
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- 2012
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30. Genomic analysis of Klebsiella pneumoniae isolates from Malawi reveals acquisition of multiple ESBL determinants across diverse lineages
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Musicha, Patrick, primary, Msefula, Chisomo L, additional, Mather, Alison E, additional, Chaguza, Chrispin, additional, Cain, Amy K, additional, Peno, Chikondi, additional, Kallonen, Teemu, additional, Khonga, Margaret, additional, Denis, Brigitte, additional, Gray, Katherine J, additional, Heyderman, Robert S, additional, Thomson, Nicholas R, additional, Everett, Dean B, additional, and Feasey, Nicholas A, additional
- Published
- 2019
- Full Text
- View/download PDF
31. Both the inflammatory response and clinical outcome differ markedly between adults with pneumococcal and meningococcal meningitis in a high HIV-1 prevalent setting in sub-Saharan Africa
- Author
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Wall, Emma C, primary, Guerra-Assunção, José Afonso, additional, Denis, Brigitte, additional, Scarborough, Matthew, additional, Ajdukiewicz, Katherine, additional, Cartwright, Katharine, additional, Mukaka, Mavuto, additional, Mlozowa, Veronica S, additional, Venturini, Cristina, additional, Allain, Theresa J, additional, Lalloo, David G, additional, Brown, Jeremy S, additional, Gordon, Stephen B, additional, and Heyderman, Robert S, additional
- Published
- 2019
- Full Text
- View/download PDF
32. Emerging Resistance to Empiric Antimicrobial Regimens for Pediatric Bloodstream Infections in Malawi (1998–2017)
- Author
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Iroh Tam, Pui-Ying, primary, Musicha, Patrick, additional, Kawaza, Kondwani, additional, Cornick, Jenifer, additional, Denis, Brigitte, additional, Freyne, Bridget, additional, Everett, Dean, additional, Dube, Queen, additional, French, Neil, additional, Feasey, Nicholas, additional, and Heyderman, Robert, additional
- Published
- 2018
- Full Text
- View/download PDF
33. Effect of ready-to-use supplementary food on mortality in severely immunocompromised HIV-infected individuals in Africa initiating antiretroviral therapy (REALITY): an open-label, parallel-group, randomised controlled trial
- Author
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Mallewa, Jane, primary, Szubert, Alexander J, additional, Mugyenyi, Peter, additional, Chidziva, Ennie, additional, Thomason, Margaret J, additional, Chepkorir, Priscilla, additional, Abongomera, George, additional, Baleeta, Keith, additional, Etyang, Anthony, additional, Warambwa, Colin, additional, Melly, Betty, additional, Mudzingwa, Shepherd, additional, Kelly, Christine, additional, Agutu, Clara, additional, Wilkes, Helen, additional, Nkomani, Sanele, additional, Musiime, Victor, additional, Lugemwa, Abbas, additional, Pett, Sarah L, additional, Bwakura-Dangarembizi, Mutsa, additional, Prendergast, Andrew J, additional, Gibb, Diana M, additional, Walker, A Sarah, additional, Berkley, James A, additional, Kityo, Cissy, additional, Wavamunno, Priscilla, additional, Nambi, Esther, additional, Ocitti, Paul, additional, Ndigendawani, Milly, additional, Kabahenda, Sheila, additional, Kemigisa, Mable, additional, Acen, Juliet, additional, Olebo, David Francis, additional, Mpamize, Gordon, additional, Amone, Alex, additional, Okweny, David, additional, Mbonye, Andrew, additional, Nambaziira, Florence, additional, Rweyora, Angela, additional, Kangah, Mary, additional, Kabaswahili, Beatrice, additional, Abach, James, additional, Omongin, Joseph, additional, Aciro, Irene, additional, Philliam, Aleti, additional, Arach, Beatrice, additional, Ocung, Emmanuel, additional, Amone, Geoffrey, additional, Miles, Peter, additional, Adong, Claudia, additional, Tumsuiime, Constance, additional, Kidega, Patrick, additional, Otto, Ben, additional, Apio, Florence, additional, Mukuye, Andrew, additional, Abwola, Mary, additional, Ssennono, Fred, additional, Baliruno, David, additional, Tuhirwe, Stephen, additional, Namisi, Ronald, additional, Kigongo, Fredrick, additional, Kikyonkyo, Dickson, additional, Mushahara, Furaha, additional, Tusiime, Julian, additional, Musiime, Alex, additional, Nankya, Agnes, additional, Atwongyeire, Dickens, additional, Sirikye, Sowal, additional, Myalo, Sula, additional, Noowe, Nelson, additional, Kasozi, Mariam, additional, Mwebe, Sandra, additional, Atwine, Lorna, additional, Senkindu, Tapson, additional, Natuhurira, Ian, additional, Katemba, Chrispus, additional, Ninsiima, Emily, additional, Acaku, Moses, additional, Kyomuhangi, Joy, additional, Ankunda, Rogers, additional, Tukwasibwe, Deogratious, additional, Ayesiga, Lillian, additional, Hakim, James, additional, Nathoo, Kusum, additional, Reid, Andrew, additional, Mhute, Tawand, additional, Tinago, Gloria, additional, Bhiri, Joyline, additional, Phiri, Misheck, additional, Steamer, John, additional, Nhema, Ruth, additional, Musoro, Godfrey, additional, Mutsai, Shirley, additional, Nemasango, Beauty, additional, Moyo, Columbus, additional, Chitongo, Stuart, additional, Rashirai, Kennias, additional, Vhembo, Sydney, additional, Mlambo, Brian, additional, Ndemera, Buxton, additional, Willard, Marko, additional, Berejena, Chipo, additional, Musodza, Yeukai, additional, Matiza, Patience, additional, Mudenge, Boniface, additional, Guti, Vongai, additional, Berkley, Jay, additional, Maitland, Kathryn, additional, Njuguna, Patricia, additional, Mwaringa, Shalton, additional, Etyang, Timothy, additional, Awuondo, Ken, additional, Wale, Stephen, additional, Shangala, Jimmy, additional, Kithunga, Jefwa, additional, Mwarumba, Salim, additional, Said Maitha, Salma, additional, Mutai, Robert, additional, Lozi Lewa, Margaret, additional, Mwambingu, Gabriel, additional, Mwanzu, Alfred, additional, Kalama, Connie, additional, Latham, Helen, additional, Shikuku, Joyce, additional, Fondo, Amos, additional, Njogu, Anne, additional, Khadenge, Connie, additional, Mwakisha, Bryan, additional, Siika, Abraham, additional, Wools-Kaloustian, Kara, additional, Nyandiko, Winston, additional, Chepkorir-Cheruiyot, Priscilla, additional, Sudoi, Allan, additional, Wachira, Simon, additional, Meli, Betty, additional, Karoney, Mercy, additional, Nzioka, Agnes, additional, Tanui, Michael, additional, Mokaya, Martha, additional, Ekiru, Wilson, additional, Mboya, Chris, additional, Mwimali, Dorothy, additional, Mengich, Cecilia, additional, Choge, Julie, additional, Injera, Wilfred, additional, Njenga, Kennedy, additional, Cherutich, Salinah, additional, Anyango Orido, Millicent, additional, Omondi Lwande, Gerald, additional, Rutto, Peter, additional, Mudogo, Alice, additional, Kutto, Irene, additional, Shali, Amina, additional, Jaika, Linda, additional, Jerotich, Hellen, additional, Pierre, Mowlem, additional, Mallewa, Jane, additional, Kaunda, Symon, additional, Van Oosterhout, Joep, additional, O'Hare, Bernadette, additional, Heydermann, Robert, additional, Gonzalez, Carmen, additional, Dzabala, Nettie, additional, Denis, Brigitte, additional, Selemani, George, additional, Nyondo- Mipando, Linda, additional, Chirwa, Emmie, additional, Banda, Peter, additional, Mvula, Linley, additional, Msuku, Harrison, additional, Ziwoya, Milton, additional, Manda, Yollam, additional, Nicholas, Simon, additional, Masesa, Clemens, additional, Mwalukomo, Thandi, additional, Makhaza, Lumbani, additional, Sheha, Irene, additional, Bwanali, Joseph, additional, Limbuni, Molly, additional, Walker, Ann Sarah, additional, Griffiths, Anna, additional, Rajapakse, Chathurika, additional, Spyer, Moira J, additional, Klein, Nigel, additional, Rauchenberger, Mary, additional, Van Looy, Nadine, additional, Little, Emma, additional, Fairbrother, Keith, additional, Cowan, Frances, additional, Seeley, Janet, additional, Bernays, Sarah, additional, Kawuma, Rachel, additional, and Mupambireyi, Zivai, additional
- Published
- 2018
- Full Text
- View/download PDF
34. Goal directed therapy for suspected acute bacterial meningitis in adults and adolescents in sub-Saharan Africa
- Author
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Wall, Emma C., primary, Mukaka, Mavuto, additional, Denis, Brigitte, additional, Mlozowa, Veronica S., additional, Msukwa, Malango, additional, Kasambala, Khumbo, additional, Nyrienda, Mulinda, additional, Allain, Theresa J., additional, Faragher, Brian, additional, Heyderman, Robert S., additional, and Lalloo, David G., additional
- Published
- 2017
- Full Text
- View/download PDF
35. Early goal directed therapy for adult bacterial meningitis in Malawi v1
- Author
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C, Emma, primary, Mukaka, Mavuto, additional, Denis, Brigitte, additional, S, Veronica, additional, Msukwa, Malango, additional, Kasambala, Khumbo, additional, Nyrienda, Mulinda, additional, J, Theresa, additional, Faragher, Brian, additional, S, Robert, additional, and G, David, additional
- Published
- 2017
- Full Text
- View/download PDF
36. Avaliação da eficácia de medidas para o controlo de Salmonella spp. e E. coli O157:H7 na preparação de francesinhas
- Author
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Denis, Brigitte Gomes and Patarata, Luís
- Subjects
614.31(043) ,Restauração ,Francesinha ,Segurança alimentar ,579.67(043) - Abstract
Dissertação de Mestrado em Segurança Alimentar O presente trabalho aborda a avaliação da eficácia de medidas para o controlo de Salmonella spp. e E. coli O157:H7 na preparação de francesinhas. O estudo foi realizado num restaurante, onde a quantidade servida é relativamente grande. Assim, surgiu o interesse de avaliar e validar os processos de confeção dos alimentos de risco inerentes à constituição da francesinha. O trabalho foi desenvolvido em três fases, sendo que a primeira é respeitante às condições higiénico-sanitárias do estabelecimento, onde envolve três vertentes, a conformidade dos pré-requisitos, o conhecimento dos manipuladores de alimentos e qualidade da sua prática quotidiana. Relativamente à conformidade dos pré-requisitos, foi avaliada pela aplicação de uma lista de verificação elaborada para o efeito. O conhecimento dos MA foi feito com base num questionário. A grelha de observação serviu para avaliar a prática dos MA decorrente da laboração com registo da mesma. A segunda fase diz respeito à elaboração de um plano HACCP para a preparação das francesinhas. Na terceira e última fase estudou-se, o comportamento de dois microrganismos patogénicos considerados potenciais perigos biológicos nas matérias-primas de maior risco usados na preparação de francesinhas. O estabelecimento de restauração onde este trabalho foi desenvolvido apresentava genericamente boas condições estruturais e de funcionamento. Os conhecimentos dos manipuladores de alimentos desse estabelecimento revelaram algumas fragilidades, particularmente ao nível da utilização do frio e dos tratamentos térmicos. A prática corrente dos manipuladores registada através de uma grelha de observação revelou que ainda há algum trabalho a fazer na qualidade das suas práticas, quer ao nível da lavagem das mãos, quer ao nível da prevenção das contaminações cruzadas e da correta preparação dos alimentos. A análise do plano HACCP e os ensaios realizados para testar o potencial da francesinha ser responsável por toxinfeções por Salmonella spp. ou E. coli O157:H7 demonstrou que, quando os ingredientes de risco – carne de bovino e ovo - são corretamente cozinhados, o perigo é eliminado. A preparação de francesinha com bife ou ovo mal passado não garante a eliminação de qualquer dos dois microrganismos testados, pelo que a segurança desta preparação de cafetaria fica muito dependente da qualidade microbiológica das matérias-primas, pelo que se recomenda que a satisfação dos pedidos de clientes de francesinhas com bife ou ovo mal passado seja cuidadosamente ponderado. The present study approaches the evaluation of the effectiveness of measures to control of Salmonella spp . and E. coli O157: H7 in the preparation of francesinhas . The study was conducted in a restaurant where the quantity served is relatively large, so the interest to evaluate and validate the processes of preparation of hazardous ingredients of Francesinhas. The study was conducted in three phases, the first hygienic conditions of the establishment were evaluated throughout the application of a checklist for the prerequisites and a questionnaire and an observation grid for the knowledge and practices of food handlers. In a second phase it was developed a HACCP plan for the preparation of francesinhas. In the last phase, It was studied measures to validate the safety of hazardous ingredients. The cafeteria where this work was conducted had good structural and operating conditions. The Knowledge of foodhandlers revealed some weaknesses, particularly regarding the correctness of the use of cold and heat treatments. The current practice of food handlers registered through a observation grid revealed that there is still some work to do on the quality of their practices, both in hand washing, prevention of cross-contamination and proper food preparation. The analysis of the HACCP plan and tests performed to study the potential of francesinha to be responsible for Salmonella spp . or E. coli O157 : H7 foodborne ilness showed that when risk the ingredients - beef and egg - are properly cooked , the hazard is eliminated. The preparation of francesinha with undercooked steak or egg does not guarantee the elimination of any of the two pathogens , so the safety of this cafeteria sandwich is very dependent on the microbiological quality of raw materials, it is recommended that the satisfaction of clients’ requests for francesinhas with undercooked steak or egg should be carefully considered.
- Published
- 2015
37. Emerging Resistance to Empiric Antimicrobial Regimens for Pediatric Bloodstream Infections in Malawi (1998–2017).
- Author
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Tam, Pui-Ying Iroh, Musicha, Patrick, Kawaza, Kondwani, Cornick, Jenifer, Denis, Brigitte, Freyne, Bridget, Everett, Dean, Dube, Queen, French, Neil, Feasey, Nicholas, and Heyderman, Robert
- Subjects
ANTI-infective agents ,GENTAMICIN ,PENICILLIN ,AMPICILLIN ,CEFTRIAXONE ,BLOOD ,CELL culture ,HOSPITAL care of children ,DRUG resistance in microorganisms ,HEALTH facilities ,SEPSIS ,DISEASE incidence ,KLEBSIELLA infections ,CHILDREN ,THERAPEUTICS - Abstract
The article presents a study which described trends in etiologies and susceptibility patterns of bloodstream infections (BSI) in hospitalized children in Malawi from 1998 to 2017. Topics discussed include the decline in child mortality in Malawi in the last 20 years due to multiple interventions, decrease in minimum incidence rates of pediatric BSI over 20 years, and pathogen etiology.
- Published
- 2019
- Full Text
- View/download PDF
38. KNOWLEDGE TRANSFER IN REGULATORY ANALYTICAL SCIENCES THROUGH THE IMPLEMENTATION OF COMMUNITIES OF PRACTICE
- Author
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Jesionkowska, Joanna, Denis, Brigitte, and Taylor, Philip
- Published
- 2014
- Full Text
- View/download PDF
39. Prediction of Outcome From Adult Bacterial Meningitis in a High-HIV-Seroprevalence, Resource-Poor Setting Using the Malawi Adult Meningitis Score (MAMS)
- Author
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Wall, Emma C., primary, Mukaka, Mavuto, additional, Scarborough, Matthew, additional, Ajdukiewicz, Katherine M. A., additional, Cartwright, Katharine E., additional, Nyirenda, Mulinda, additional, Denis, Brigitte, additional, Allain, Theresa J., additional, Faragher, Brian, additional, Lalloo, David G., additional, and Heyderman, Robert S., additional
- Published
- 2016
- Full Text
- View/download PDF
40. OPTIMISATION OF COLLABORATIVE KNOWLEDGE-BUILDING IN THE COMMUNITY OF SCIENTISTS BY THE DEVELOPMENT OF A COMMUNITY OF PRACTICE IN THE DOMAIN OF ANALYTICAL CHEMISTRY
- Author
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Jesionkowska, Joanna, primary and Denis, Brigitte, additional
- Published
- 2016
- Full Text
- View/download PDF
41. Modelling the Contributions of Malaria, HIV, Malnutrition and Rainfall to the Decline in Paediatric Invasive Non-typhoidal Salmonella Disease in Malawi
- Author
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Feasey, Nicholas A., primary, Everett, Dean, additional, Faragher, E. Brian, additional, Roca-Feltrer, Arantxa, additional, Kang’ombe, Arthur, additional, Denis, Brigitte, additional, Kerac, Marko, additional, Molyneux, Elizabeth, additional, Molyneux, Malcolm, additional, Jahn, Andreas, additional, Gordon, Melita A., additional, and Heyderman, Robert S., additional
- Published
- 2015
- Full Text
- View/download PDF
42. Environnements Personnels d’Apprentissage : exploration des représentations et usages d’étudiants de l’enseignement supérieur
- Author
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Denis, Brigitte, primary and Joris, Noémie, additional
- Published
- 2014
- Full Text
- View/download PDF
43. A Prospective Longitudinal Study of the Clinical Outcomes from Cryptococcal Meningitis following Treatment Induction with 800 mg Oral Fluconazole in Blantyre, Malawi
- Author
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Rothe, Camilla, primary, Sloan, Derek J., additional, Goodson, Patrick, additional, Chikafa, Jean, additional, Mukaka, Mavuto, additional, Denis, Brigitte, additional, Harrison, Tom, additional, van Oosterhout, Joep J., additional, Heyderman, Robert S., additional, Lalloo, David G., additional, Allain, Theresa, additional, and Feasey, Nicholas A., additional
- Published
- 2013
- Full Text
- View/download PDF
44. Risk Factors for Death and Severe Sequelae in Malawian Children With Bacterial Meningitis, 1997–2010
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McCormick, David W., primary, Wilson, Mark L., additional, Mankhambo, Limangeni, additional, Phiri, Ajib, additional, Chimalizeni, Yamikani, additional, Kawaza, Kondwani, additional, Denis, Brigitte, additional, Carrol, Enitan D., additional, and Molyneux, Elizabeth M., additional
- Published
- 2013
- Full Text
- View/download PDF
45. Genetic Characterisation of Malawian Pneumococci Prior to the Roll-Out of the PCV13 Vaccine Using a High-Throughput Whole Genome Sequencing Approach
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Everett, Dean B., primary, Cornick, Jennifer, additional, Denis, Brigitte, additional, Chewapreecha, Claire, additional, Croucher, Nicholas, additional, Harris, Simon, additional, Parkhill, Julian, additional, Gordon, Stephen, additional, Carrol, Enitan D., additional, French, Neil, additional, Heyderman, Robert S., additional, and Bentley, Stephen D., additional
- Published
- 2012
- Full Text
- View/download PDF
46. Stories About Innovative Processes In Higher Education : Some Success Factors
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UCL - Autre, Charlier, Bernadette, Platteaux, Hervé, Bouvy, Marie-Thérèse, Esnault, Liliane, Lebrun, Marcel, Moura, Ana, Pirotte, Sébastien, Denis, Brigitte, Verday, Nathalie, Network Learning - Lancaster, UCL - Autre, Charlier, Bernadette, Platteaux, Hervé, Bouvy, Marie-Thérèse, Esnault, Liliane, Lebrun, Marcel, Moura, Ana, Pirotte, Sébastien, Denis, Brigitte, Verday, Nathalie, and Network Learning - Lancaster
- Published
- 2004
47. Taking "pragmatic dimensions" of ontologies into account
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Giboin, Alain, primary, Denis, Brigitte, additional, and Snoeck, Céline, additional
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- 2011
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48. InvasiveStreptococcus pneumoniaein Children, Malawi, 2004–2006
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Cornick, Jennifer E., primary, Everett, Dean B., additional, Broughton, Caroline, additional, Denis, Brigitte B., additional, Banda, Daniel L., additional, Carrol, Enitan D., additional, and Parry, Christopher M., additional
- Published
- 2011
- Full Text
- View/download PDF
49. Ten Years of Surveillance for Invasive Streptococcus pneumoniae during the Era of Antiretroviral Scale-Up and Cotrimoxazole Prophylaxis in Malawi
- Author
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Everett, Dean B., primary, Mukaka, Mavuto, additional, Denis, Brigitte, additional, Gordon, Stephen B., additional, Carrol, Enitan D., additional, van Oosterhout, Joep J., additional, Molyneux, Elizabeth M., additional, Molyneux, Malcolm, additional, French, Neil, additional, and Heyderman, Robert S., additional
- Published
- 2011
- Full Text
- View/download PDF
50. Learn-Nett : une expérience d'apprentissage collaboratif à distance
- Author
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UCL - Autre, UCL - PSP/EDUC - Département des sciences de l'éducation, Charlier, Bernadette, Daele, Amaury, Docq, Françoise, Hecquet, Geoffroy, Lebrun, Marcel, Denis, Brigitte, PEETERS, Robert, De Lièvre, Bruno, Deschryver, N., Lusalusa, S., Peraya, Daniel, UCL - Autre, UCL - PSP/EDUC - Département des sciences de l'éducation, Charlier, Bernadette, Daele, Amaury, Docq, Françoise, Hecquet, Geoffroy, Lebrun, Marcel, Denis, Brigitte, PEETERS, Robert, De Lièvre, Bruno, Deschryver, N., Lusalusa, S., and Peraya, Daniel
- Published
- 2000
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