6 results on '"Deniel, Azura"'
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2. Age-specific breast and ovarian cancer risks associated with germline BRCA1 or BRCA2 pathogenic variants – an Asian study of 572 families
- Author
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Ho, Weang-Kee, primary, Hassan, Nur Tiara, additional, Yoon, Sook-Yee, additional, Yang, Xin, additional, Lim, Joanna M.C., additional, Binte Ishak, Nur Diana, additional, Ho, Peh Joo, additional, Wijaya, Eldarina A., additional, Ng, Patsy Pei-Sze, additional, Luccarini, Craig, additional, Allen, Jamie, additional, Tai, Mei-Chee, additional, Chiang, Jianbang, additional, Zhang, Zewen, additional, See, Mee-Hoong, additional, Thong, Meow-Keong, additional, Woo, Yin-Ling, additional, Dunning, Alison M., additional, Hartman, Mikael, additional, Yip, Cheng-Har, additional, Mohd Taib, Nur Aishah, additional, Easton, Douglas F., additional, Li, Jingmei, additional, Ngeow, Joanne, additional, Antoniou, Antonis C., additional, Teo, Soo-Hwang, additional, Kiat-Tee Tan, Benita, additional, Tan, Su-Ming, additional, Mien Tan, Veronique Kiak, additional, Tan, Ern Yu, additional, Lim, Geok Hoon, additional, Khng, Alexis, additional, Ch’ng, Gaik-Siew, additional, Omar, Jamil, additional, Yong, Chee-Meng, additional, Aliyas, Ismail, additional, Malik, Rozita Abdul, additional, Subramaniam, Suguna, additional, Sim, Wee-Wee, additional, Lim, Chun Sen, additional, Lee, Saw-Joo, additional, Lim, Keng-Joo, additional, Shafiee, Mohamad Nasir, additional, Ismail, Fuad Ismail, additional, Ismail, Mohd Pazudin, additional, Mohamed Jamli, Mohamad Faiz, additional, Kumarasamy, Suresh, additional, Low, John S.H., additional, Ahmad Mustafa, Ahmad Muzamir, additional, Makanjang, Mary J., additional, Taib, Shahila, additional, Cheah, Nellie, additional, Fong, Chee-Kin, additional, Ho, Kean-Fatt, additional, Deniel, Azura, additional, Ang, Soo Fan, additional, Ahmad Badruddin, Ahmad Radzi, additional, and Tho, Lye-Mun, additional
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- 2024
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3. Baseline cardiovascular comorbidities, and the influence on cancer treatment decision-making in women with breast cancer
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Subramaniam, Shridevi, primary, Kong, Yek-Ching, additional, Zaharah, Hafizah, additional, Uiterwaal, Cuno SPM, additional, Richard, Andrea, additional, Tab, Nur Aishah, additional, Deniel, Azura, additional, Chee, Kok-Han, additional, Bustamam, Ros Suzanna, additional, See, Mee-Hoong, additional, Fong, Alan, additional, Yip, Cheng-Har, additional, and Bhoo-Pathy, Nirmala, additional
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- 2021
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4. Oncologist-led BRCA counselling improves access to cancer genetic testing in middle-income Asian country, with no significant impact on psychosocial outcomes
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Yoon, Sook-Yee, primary, Wong, Siu Wan, additional, Lim, Joanna, additional, Ahmad, Syuhada, additional, Mariapun, Shivaani, additional, Padmanabhan, Heamanthaa, additional, Hassan, Nur Tiara, additional, Lau, Shao Yan, additional, Ch'ng, Gaik-Siew, additional, Haniffa, Muzhirah, additional, Ong, Winnie P, additional, Rethanavelu, Kavitha, additional, Moey, Lip Hen, additional, Keng, Wee Teik, additional, Omar, Jamil, additional, Mohd Abas, Mohd Norazam, additional, Yong, Chee Meng, additional, Ramasamy, Vickneswaren, additional, Md Noor, Mohd Rushdan, additional, Aliyas, Ismail, additional, Lim, Michael C K, additional, Suberamaniam, Anuradha, additional, Mat Adenan, Noor Azmi, additional, Ahmad, Zatul Akmar, additional, Ho, Gwo Fuang, additional, Abdul Malik, Rozita, additional, Subramaniam, Suguna, additional, Khoo, Boom Ping, additional, Raja, Arivendran, additional, Chin, Yeung Sing, additional, Sim, Wee Wee, additional, Teh, Beng Hock, additional, Kho, Swee Kiong, additional, Ong, Eunice S E, additional, Voon, Pei Jye, additional, Ismail, Ghazali, additional, Lee, Chui Ling, additional, Abdullah, Badrul Zaman, additional, Loo, Kwong Sheng, additional, Lim, Chun Sen, additional, Lee, Saw Joo, additional, Lim, Keng Joo Lim, additional, Shafiee, Mohamad Nasir, additional, Ismail, Fuad, additional, Latiff, Zarina Abdul, additional, Ismail, Mohd Pazudin, additional, Mohamed Jamli, Mohamad Faiz, additional, Kumarasamy, Suresh, additional, Leong, Kin Wah, additional, Low, John, additional, Md Yusof, Mastura, additional, Ahmad Mustafa, Ahmad Muzamir, additional, Mat Ali, Nor Huda, additional, Makanjang, Mary, additional, Tayib, Shahila, additional, Cheah, Nellie, additional, Lim, Boon Kiong, additional, Fong, Chee Kin, additional, Foo, Yoke Ching, additional, Mellor Abdullah, Matin, additional, Tan, Teck Sin, additional, Chow, Doris S Y, additional, Ho, Kean Fatt, additional, Raman, Rakesh, additional, Radzi, Ahmad, additional, Deniel, Azura, additional, Teoh, Daren C Y, additional, Ang, Soo Fan, additional, Joseph, Joseph K, additional, Ng, Paul Hock Oon, additional, Tho, Lye-Mun, additional, Ahmad, Azura Rozila, additional, Muin, Ileena, additional, Bleiker, Eveline, additional, George, Angela, additional, Thong, Meow-Keong, additional, Woo, Yin Ling, additional, and Teo, Soo Hwang, additional
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- 2021
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5. Oncologist-led BRCAcounselling improves access to cancer genetic testing in middle-income Asian country, with no significant impact on psychosocial outcomes
- Author
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Yoon, Sook-Yee, Wong, Siu Wan, Lim, Joanna, Ahmad, Syuhada, Mariapun, Shivaani, Padmanabhan, Heamanthaa, Hassan, Nur Tiara, Lau, Shao Yan, Ch'ng, Gaik-Siew, Haniffa, Muzhirah, Ong, Winnie P, Rethanavelu, Kavitha, Moey, Lip Hen, Keng, Wee Teik, Omar, Jamil, Mohd Abas, Mohd Norazam, Yong, Chee Meng, Ramasamy, Vickneswaren, Md Noor, Mohd Rushdan, Aliyas, Ismail, Lim, Michael C K, Suberamaniam, Anuradha, Mat Adenan, Noor Azmi, Ahmad, Zatul Akmar, Ho, Gwo Fuang, Abdul Malik, Rozita, Subramaniam, Suguna, Khoo, Boom Ping, Raja, Arivendran, Chin, Yeung Sing, Sim, Wee Wee, Teh, Beng Hock, Kho, Swee Kiong, Ong, Eunice S E, Voon, Pei Jye, Ismail, Ghazali, Lee, Chui Ling, Abdullah, Badrul Zaman, Loo, Kwong Sheng, Lim, Chun Sen, Lee, Saw Joo, Lim, Keng Joo Lim, Shafiee, Mohamad Nasir, Ismail, Fuad, Latiff, Zarina Abdul, Ismail, Mohd Pazudin, Mohamed Jamli, Mohamad Faiz, Kumarasamy, Suresh, Leong, Kin Wah, Low, John, Md Yusof, Mastura, Ahmad Mustafa, Ahmad Muzamir, Mat Ali, Nor Huda, Makanjang, Mary, Tayib, Shahila, Cheah, Nellie, Lim, Boon Kiong, Fong, Chee Kin, Foo, Yoke Ching, Mellor Abdullah, Matin, Tan, Teck Sin, Chow, Doris S Y, Ho, Kean Fatt, Raman, Rakesh, Radzi, Ahmad, Deniel, Azura, Teoh, Daren C Y, Ang, Soo Fan, Joseph, Joseph K, Ng, Paul Hock Oon, Tho, Lye-Mun, Ahmad, Azura Rozila, Muin, Ileena, Bleiker, Eveline, George, Angela, Thong, Meow-Keong, Woo, Yin Ling, and Teo, Soo Hwang
- Abstract
BackgroundIdentifying patients with BRCAmutations is clinically important to inform on the potential response to treatment and for risk management of patients and their relatives. However, traditional referral routes may not meet clinical needs, and therefore, mainstreaming cancer genetics has been shown to be effective in some high-income and high health-literacy settings. To date, no study has reported on the feasibility of mainstreaming in low-income and middle-income settings, where the service considerations and health literacy could detrimentally affect the feasibility of mainstreaming.MethodsThe Mainstreaming Genetic Counselling for Ovarian Cancer Patients (MaGiC) study is a prospective, two-arm observational study comparing oncologist-led and genetics-led counselling. This study included 790 multiethnic patients with ovarian cancer from 23 sites in Malaysia. We compared the impact of different method of delivery of genetic counselling on the uptake of genetic testing and assessed the feasibility, knowledge and satisfaction of patients with ovarian cancer.ResultsOncologists were satisfied with the mainstreaming experience, with 95% indicating a desire to incorporate testing into their clinical practice. The uptake of genetic testing was similar in the mainstreaming and genetics arm (80% and 79%, respectively). Patient satisfaction was high, whereas decision conflict and psychological impact were low in both arms of the study. Notably, decisional conflict, although lower than threshold, was higher for the mainstreaming group compared with the genetics arm. Overall, 13.5% of patients had a pathogenic variant in BRCA1or BRCA2,and there was no difference between psychosocial measures for carriers in both arms.ConclusionThe MaGiC study demonstrates that mainstreaming cancer genetics is feasible in low-resource and middle-resource Asian setting and increased coverage for genetic testing.
- Published
- 2022
- Full Text
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6. Oncologist-led BRCA counselling improves access to cancer genetic testing in middle-income Asian country, with no significant impact on psychosocial outcomes.
- Author
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Yoon SY, Wong SW, Lim J, Ahmad S, Mariapun S, Padmanabhan H, Hassan NT, Lau SY, Ch'ng GS, Haniffa M, Ong WP, Rethanavelu K, Moey LH, Keng WT, Omar J, Mohd Abas MN, Yong CM, Ramasamy V, Md Noor MR, Aliyas I, Lim MCK, Suberamaniam A, Mat Adenan NA, Ahmad ZA, Ho GF, Abdul Malik R, Subramaniam S, Khoo BP, Raja A, Chin YS, Sim WW, Teh BH, Kho SK, Ong ESE, Voon PJ, Ismail G, Lee CL, Abdullah BZ, Loo KS, Lim CS, Lee SJ, Lim KJL, Shafiee MN, Ismail F, Latiff ZA, Ismail MP, Mohamed Jamli MF, Kumarasamy S, Leong KW, Low J, Md Yusof M, Ahmad Mustafa AM, Mat Ali NH, Makanjang M, Tayib S, Cheah N, Lim BK, Fong CK, Foo YC, Mellor Abdullah M, Tan TS, Chow DSY, Ho KF, Raman R, Radzi A, Deniel A, Teoh DCY, Ang SF, Joseph JK, Ng PHO, Tho LM, Ahmad AR, Muin I, Bleiker E, George A, Thong MK, Woo YL, and Teo SH
- Subjects
- BRCA1 Protein genetics, BRCA2 Protein genetics, Counseling, Female, Genetic Counseling, Genetic Testing methods, Humans, Prospective Studies, Oncologists, Ovarian Neoplasms diagnosis, Ovarian Neoplasms epidemiology, Ovarian Neoplasms genetics
- Abstract
Background: Identifying patients with BRCA mutations is clinically important to inform on the potential response to treatment and for risk management of patients and their relatives. However, traditional referral routes may not meet clinical needs, and therefore, mainstreaming cancer genetics has been shown to be effective in some high-income and high health-literacy settings. To date, no study has reported on the feasibility of mainstreaming in low-income and middle-income settings, where the service considerations and health literacy could detrimentally affect the feasibility of mainstreaming., Methods: The Mainstreaming Genetic Counselling for Ovarian Cancer Patients (MaGiC) study is a prospective, two-arm observational study comparing oncologist-led and genetics-led counselling. This study included 790 multiethnic patients with ovarian cancer from 23 sites in Malaysia. We compared the impact of different method of delivery of genetic counselling on the uptake of genetic testing and assessed the feasibility, knowledge and satisfaction of patients with ovarian cancer., Results: Oncologists were satisfied with the mainstreaming experience, with 95% indicating a desire to incorporate testing into their clinical practice. The uptake of genetic testing was similar in the mainstreaming and genetics arm (80% and 79%, respectively). Patient satisfaction was high, whereas decision conflict and psychological impact were low in both arms of the study. Notably, decisional conflict, although lower than threshold, was higher for the mainstreaming group compared with the genetics arm. Overall, 13.5% of patients had a pathogenic variant in BRCA1 or BRCA2, and there was no difference between psychosocial measures for carriers in both arms., Conclusion: The MaGiC study demonstrates that mainstreaming cancer genetics is feasible in low-resource and middle-resource Asian setting and increased coverage for genetic testing., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2022
- Full Text
- View/download PDF
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