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8 results on '"Deng, Guolan"'

7. Anti-inflammatory effects of neferine on LPS-induced human endothelium

Author

Deng, Guolan, Wang, Lingli, He, Wenyi, Zhou, Wei, Chen, Baowei, and Bing, Sen

Subjects
Inflammation, Lipopolysaccharides, Dose-Response Relationship, Drug, Tumor Necrosis Factor-alpha, Anti-Inflammatory Agents, NF-kappa B, Nitric Oxide Synthase Type II, Atherosclerosis, Nitric Oxide, Benzylisoquinolines, Rats, Cyclooxygenase 2, Human Umbilical Vein Endothelial Cells, Animals, Cytokines, Humans, Inflammation Mediators, Mitogen-Activated Protein Kinases, Aorta, Cells, Cultured
Abstract

This study aimed to evaluate the anti-inflammatory mechanism of neferine, a bisbenzylisoquinoline alkaloid, on the lipopolysaccharide (LPS)-induced inflammation in Human Umbilical Endothelial Cells (HUVECs) and pulmonary aorta cells. Production of pro-inflammatory cytokines and nitric oxide (NO) was determined using Griess reaction in human endothelial cells. The levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and mitogen-activated protein kinases (MAPKs) were analyzed using real time PCR and western blotting. Neferine significantly prevented the NO, TNF-α, COX-2, iNOS, IL-1B, and other inflammatory mediators formation in increasing dose as compared to LPS-induced human endothelial cells. The expressions of NADPH oxidase subunits p22phox, p47phox, and gp91phox were increased in LPS-induced HUVECs but neferein was able to reverse the effect in a dose-dependent manner. The anti-inflammatory effects of neferine in LPS-induced endothelial cells are attributed through the modulation of MAPK and NF-κβ pathways. Collectively, these results suggest that neferine could be beneficial in the early treatment of atherosclerosis to prevent stroke and heart disease.

Published
2018

8. Seasonal variation in diurnal blood pressure pattern.

Author

Du X, Wang L, He W, Fu X, Zhang Y, Zhou W, Han Y, and Deng G

Subjects
Humans, Male, Adult, Middle Aged, Aged, Blood Pressure physiology, Seasons, Risk Factors, Blood Pressure Monitoring, Ambulatory, Circadian Rhythm physiology, Hypertension
Abstract

Aims: To explore the relationship between diurnal blood pressure (BP) pattern and season., Methods: A total of 6765 eligible patients (average age 57.35 ± 15.53 years; male 51.8%; hypertensives 68.8%) from 1 October 2016 to 6 April 2022 were enrolled, who were divided into four dipper groups, dipper, non-dipper, riser, and extreme-dipper, according to the diurnal BP pattern calculated using their ambulatory BP monitoring data. The season which the patient was in was determined by the time of ambulatory BP monitoring examination., Results: Among the 6765 patients, 2042 (31.18%) were grouped into dipper, 380 (5.6%) into extreme-dipper, 1498 (22.1%) into riser and 2845 (42.1%) into non-dipper. Only the dipper subjects showed age difference among seasons, with the average age significantly lower in winter. There was no seasonal difference in age for the other types. No seasonal difference was revealed in gender, BMI, hypertension or not. Diurnal BP patterns significantly differed among seasons ( P  < .001). Post hoc tests with Bonferroni correction indicated the significantly different diurnal BP pattern between any two seasons ( P  < .001), but not between spring and autumn ( P  = .257), and the significance of the P value was assessed at 0.008 (0.05/6) after Bonferroni correction. Multinomial logistic regression suggested season as an independent contributor to diurnal BP pattern., Conclusion: Diurnal BP pattern is influenced by season.

Published
2023
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