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178 results on '"Deng, Chengliang"'

8. Therapeutic potential of microRNA-engineered exosomes in diabetic wound healing: a meta-analysis.

Author

Jian, Xichao, Han, Jiansu, Chen, Junzhe, Xiao, Shune, and Deng, Chengliang

Subjects
WOUND healing, EXOSOMES, DIABETES complications, CLINICAL trials, HYPERTROPHIC scars, SCARS
Abstract

Diabetic wounds, a prevalent diabetes complication, pose significant challenges in treatment. MicroRNA-engineered exosomes (miR-exo) are a promising new treatment for diabetic wounds; however, their mechanism remains to be completely understood. Therefore, we aimed to conduct a meta-analysis to evaluate the efficacy of miR-exo treatment in the management of diabetic wounds. To achieve this aim, academic databases, including PubMed, Embase, Web of Science, and the Cochrane Library, were searched for papers published before July 4, 2023. Outcome indicators (e.g., rate of wound healing, neovascular count, rate of re-epithelialization, deposition of collagen, breadth of scar, and inflammatory factors) were assessed. Six studies (total of 72 animals) met inclusion criteria and were analyzed. The amalgamated data revealed that miR-exo treatment exhibited superior results compared to those of control therapy. miR-exo treatment significantly enhanced the rate of wound healing, increased the number of neovascular formations, accelerated the rate of re-epithelialization, increased collagen deposition, reduced scar width, while significantly downregulating the expression of inflammatory factors. Our findings indicate that miR-exo treatment augments overall diabetic wound healing, especially when administered in conjunction with innovative dressings. To ascertain the optimal parameters for miR-exo treatment in managing diabetic wounds, future studies must encompass rigorous, large-scale, double-blinded clinical trials while incorporating long-term follow-up assessments for enhanced reliability and accuracy. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Combining antibiotic‐loaded bone cement‐based free vastus lateralis muscle‐sparing flap with split‐thickness skin grafts: A reliable strategy for reconstructing diabetic foot ulcers at non‐weight‐bearing areas.

Author

Chang, Shusen, Jian, Yang, Liu, Chenxiaoxiao, Dal Prà, Ilaria, Armato, Ubaldo, Chen, Xin, Zhou, Jian, Chen, Wei, Zhang, Fang, Nie, Kaiyu, De Santis, Daniele, Deng, Chengliang, and Wei, Zairong

Subjects
SKIN grafting, ANTIBIOTICS, TRANSPLANTATION of organs, tissues, etc., RESEARCH funding, QUESTIONNAIRES, HEALTH surveys, HEMODYNAMICS, SURGICAL flaps, IMMUNOHISTOCHEMISTRY, DIABETIC foot, BONE cements, QUALITY of life, BLOOD flow measurement, LIMB salvage, QUADRICEPS muscle, CASE studies, LENGTH of stay in hospitals, PLASTIC surgery, MEDICAL care costs
Abstract

Diabetic foot ulcers (DFUs) present significant challenges due to their associated amputation rates, mortality, treatment complexity and excessive costs. Our earlier work introduced a wound surgical integrated treatment (WSIT) for DFUs, yielding promising outcomes. This study focuses on a specific WSIT protocol employing antibiotic‐loaded bone cement (ALBC) in the first Stage, and free vastus lateralis muscle‐sparing (VLMS) flaps and split‐thickness skin grafts (STSGs) in the second stage to repair non‐weight‐bearing DFUs. From July 2021 to July 2023, seven DFU patients (aged 47–71 years) underwent this treatment. Demographic data, hospital stay and repair surgery times were collected. Histological and immunohistochemical analyses assessed angiogenesis, collagen deposition and inflammation. SF‐36 questionnaire measured pre‐ and postoperative quality of life. Preoperative ultrasound Doppler showed that the peak blood flow velocity of the recipient area artery was significantly >30 cm/s (38.6 ± 6.8 cm/s) in all patients. Muscle flap sizes varied from 8 × 3.5 × 1 to 18 × 6 × 2 cm. The operation time of the repair surgery was 156.9 ± 15.08 minutes, and the hospital stay was 18.9 ± 3.3 days. Histological analysis proved that covering DFUs with ALBC induced membrane formation and increased collagen, neovascularization and M2 macrophages fraction while reducing M1 macrophages one. All grafts survived without amputation during a 7‐ to 24‐month follow‐up, during which SF‐36 scores significantly improved. A combination of ALBC with free VLMS flaps and STSGs proved to be safe and effective for reconstructing non‐weight‐bearing DFUs. It rapidly controlled infection, enhanced life quality and foot function, and reduced hospitalization time. We advocate integrating this strategy into DFU treatment plans. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Case Report: A Preferred Reconstructing Modality to Restore Neoplastic Nasal Alar Subunit Defects: Sequential Facial Artery Perforator Flaps

Author

Wu, Bihua, Yang, Sanhong, Li, Hai, Zhang, Tianhua, Xiao, Shune, Wei, Zairong, and Deng, Chengliang

Subjects
RD1-811, Case Report, Surgery, nasolabial groove, nasal alar, nasal alar subunit, facial artery perforator flap, neoplastic nasal alar defects
Abstract

BackgroundAchieving perfect repair of a nasal defect with the recovery of cosmetic subunits has become a challenge to plastic, dermatologic, and head and neck surgeons. The study aimed to evaluate the effect of reconstructing neoplastic nasal alar subunit defects with sequential facial artery perforator flaps produced from nasolabial groove tissue.MethodsA retrospective analysis of 20 patients who had undergone reconstruction for neoplastic nasal alar defects with this technique from January 2017 to October 2019 was performed. The reconstruction procedure used sequential facial artery perforator flaps. The surgical procedure used and follow-up results achieved have been documented photographically for all patients.ResultsThe aesthetic and functional results of surgery were satisfactory in all the 20 patients. After all surgeries, the reconstructed alar tissues were compliant, bilateral symmetries of the alae and nasolabial grooves were satisfactory, and no patients exhibited color mismatches between the flaps and surrounding tissues. During a mean follow-up period of 22 months, none of the patients exhibited alar retraction, inferior displacement, deformation, or hypertrophic scarring.ConclusionsThe sequential facial artery perforator flap technique created with nasolabial groove tissue to reconstruct neoplastic nasal alar defects is a simple single-stage procedure that provides excellent surgical outcomes.

Published
2022

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