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5. When do benefits turn to risks? Impact of a 900 mL whole blood donation on Special Forces performance.

Author

Degueldre, Julie, Dessy, E., T'Sas, F., Keesebilck, E., and Deneys, V.

Subjects
PHYSICAL mobility, PHYSICAL fitness, HEART beat, EXPERIMENTAL design, HEMOGLOBINS
Abstract

Background: Special Forces (SF) teams operate in remote environments with limited medical support. As a result, they may need to rely on buddy transfusions to treat bleeding teammates. Considering that 450 mL has no direct impact on their combat performances, it might be tempting to take more blood from a compatible donor to save a hemorrhaging teammate. This study investigates the effect of a 900 mL blood donation on SF operator performance and recovery time following this donation. Study Design and Methods: Participants underwent a multifactorial assessment including measures of physiological parameters, vigilance, and physical performance. Results from the day of blood donation were compared with baseline values obtained 1 week earlier (i.e., immediate effect), as well as repeated testing at 7, 14, and approximately 30 days after blood donation (i.e., recovery period). Results: Hemoglobin levels and heart rate were affected by giving blood. The participants also experienced a significant decrease in physical performance of more than 50% immediately after blood donation. Recovery was slow over the following weeks, remaining significantly different from baseline until full recovery around day 30. However, participants were still able to respond to a simple stimulus and adjust their response, if necessary, even immediately after donating blood. Discussion: A 900 mL blood donation greatly affects the physical fitness of SF operators. A donation may be worthwhile if it is the only life‐saving procedure available and does not endanger the donor's life. The donor would then become a patient and unable to complete the mission. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Bacterial contamination in platelet concentrates

Author

Pietersz, R. N. I., Reesink, H. W., Panzer, S., Oknaian, S., Kuperman, S., Gabriel, C., Rapaille, A., Lambermont, M., Deneys, V., Sondag, D., Ramírez-Arcos, S., Goldman, M., Delage, G., Bernier, F., Germain, M., Vuk, T., Georgsen, J., Morel, P., Naegelen, C., Bardiaux, L., Cazenave, J.-P., Dreier, J., Vollmer, T., Knabbe, C., Seifried, E., Hourfar, K., Lin, C. K., Spreafico, M., Raffaele, L., Berzuini, A., Prati, D., Satake, M., de Korte, D., van der Meer, P. F., Kerkhoffs, J. L., Blanco, L., Kjeldsen-Kragh, J., Svard-Nilsson, A.-M., McDonald, C. P., Symonds, I., Moule, R., Brailsford, S., Yomtovian, R., and Jacobs, M. R.

Published
2014
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8. Extended red blood cell antigens and phenotypes in Burkina Faso: potential issues to design local population-sourced red blood cell reagent panels

Author

Sawadogo, S., Nebie, K., Ouedraogo, S.K.A., Traore, C., Koulidiati, J., Nikiema-Minoungou, M., Koala, N.G., Kafando, E., and Deneys, V.

Abstract

To date, 43 blood group systems with 349 red blood cell (RBC) antigens have been recognized. The study of their distribution is useful for blood services to improve their supply strategies for providing blood of rare phenotypes, but also to design indigenous RBC panels for alloantibody screening and identification. In Burkina Faso, the distribution of extended blood group antigens is not known. This study aimed to investigate the extended profiles of blood group antigens and phenotypes of this population and to raise limitations and potential strategies for the design of local RBC panels. We conducted a cross-sectional study that included group O blood donors. Extended phenotyping for antigens in the Rh, Kell, Kidd, Duffy, Lewis, MNS, and P1PK systems was performed using the conventional serologic tube technique. The prevalence of each antigen and phenotype combination was determined. A total of 763 blood donors were included. The majority were positive for D, c, e, and k and negative for Fyaand Fyb. The prevalence of K, Fya, Fyb, and Cwwas less than 5 percent. The most frequent Rh phenotype was Dce, and the most common probable haplotype was R0R0(69.5%). For the other blood group systems, the K−k+ (99.4%), M+N+S+s− (43.4%), and Fy(a−b−) (98.8%) phenotypes were the most frequent. Antigenic polymorphism of blood group systems by ethnicity and geography argues for the design and evaluation of population-sourced RBC panels to meet specific antibody profiles. However, some of the specificities identified in our study, such as the rarity of double-dose antigen profiles for certain antigens and the cost of antigen phenotyping tests, are major challenges to overcome.

Published
2023
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10. Positive direct antiglobulin test in COVID-19 patients: Decision-making process.

Author

UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service de biologie hématologique, UCL - (SLuc) Service de gastro-entérologie, Cabo, J, Brochier, A, Saussoy, P, van Dievoet, M-A, Capirchio, L, Delire, B, Deneys, V, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service de biologie hématologique, UCL - (SLuc) Service de gastro-entérologie, Cabo, J, Brochier, A, Saussoy, P, van Dievoet, M-A, Capirchio, L, Delire, B, and Deneys, V

Abstract

In this unprecedented crisis of severe acute respiratory syndrome coronavirus 2 and its associated coronavirus disease 2019 (COVID-19), polymerase chain reaction and then serological testing platforms have been massively developed to face the important screening demand. Polymerase chain reaction and serological testing platforms are not the only actors impacted by the crisis, transfusion services are facing important difficulties. A positive direct antiglobulin test is frequently observed for patients encountering COVID-19. Patients with severe symptoms may develop anaemia and become good candidates for blood transfusions. The interpretation of a positive direct antiglobulin test for patients recently transfused and suffering from COVID-19 is complex. The differentiation between COVID-19 induced antibodies and possible associated transfusion alloantibodies is therefore crucial. In this context, the elution technique incorporated in an appropriate decision-making process plays its full role. This intricate topic is presented through a case report followed by literature review and finally decision-making process for COVID-19 patients necessitating red blood cells administration.

Published
2021

17. Prophylactic platelet transfusions

Author

Pietersz, R. N. I., Reesink, H. W., Panzer, S., Gilbertson, M. P., Borosak, M. E., Wood, E. M., Leitner, G. C., Rabitsch, W., Ay, C., Lambermont, M., Deneys, V., Sondag, D., Compernolle, V., Legrand, D., François, A., Tardivel, R., Garban, F., Sawant, R. B., Rebulla, P., Handa, M., Ohto, H., Kerkhoffs, J.-L. H., Brand, A., Zhiburt, E., Cid, J., Escolar, G., Lozano, M., Puig, L., Knutson, F., Hallböök, H., Lubenow, N., Estcourt, L., Stanworth, S., Murphy, M. F., Williams, L., Mraz, D. L., Ross, R. L., and Snyder, E.

Published
2012
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19. Haemovigilance for the optimal use of blood products in the hospital

Author

Reesink, H. W., Panzer, S., Gonzalez, C. A., Lena, N., Muntaabski, P., Gimbatti, S., Wood, E., Lambermont, M., Deneys, V., Sondag, D., Alport, T., Towns, D., Devine, D., Turek, P., Auvinen, M. K., Koski, T., Lin, C. K., Lee, C. K., Tsoi, W. C., Lawlor, E., Grazzini, G., Piccinini, V., Catalano, L., Pupella, S., Kato, H., Takamoto, S., Okazaki, H., Hamaguchi, I., Wiersum-Osselton, J. C., van Tilborgh, A. J. W., Zijlker-Jansen, P. Y., Mangundap, K. M., Schipperus, M. R., Dinesh, D., Flanagan, P., Flesland, Ø., Steinsvåg, C. T., Espinosa, A., Letowska, M., Rosiek, A., Antoniewicz-Papis, J., Lachert, E., Koh, M. B. C., Alcantara, R., Alonso, Corral M., and Muñiz-Diaz, E.

Published
2010
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21. New cellular therapies: Is there a role for transfusion services?

Author

Reesink, H. W., Panzer, S., Dettke, M., Gabriel, C., Lambermont, M., Deneys, V., Sondag, D., Dickmeiss, E., Fischer-Nielsen, A., Korhonen, M., Krusius, T., Ali, A., Tiberghien, P., Schrezenmeier, H., Tonn, T., Seifried, E., Klüter, H., Politis, C., Stavropoulou-Gioka, A., Parara, M., Flesland, Ø., Nascimento, F., Balint, B., Marin, P., Bart, T., Chen, F. E., and Pamphilon, D. H.

Published
2009
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37. International Forum on typing and matching strategies in patients on anti-CD38 monoclonal therapy

Author

De Vooght, K. M. K., primary, Lozano, M., additional, Bueno, J-L., additional, Alarcón, A., additional, Romera, I., additional, Suzuki, K., additional, Zhiburt, E., additional, Holbro, A., additional, Infanti, L., additional, Buser, A., additional, Hustinx, H., additional, Deneys, V., additional, Frélik, A., additional, Thiry, C., additional, Murphy, M., additional, Staves, J., additional, Selleng, K., additional, Greinacher, A., additional, Kutner, J. M., additional, Bonet Bub, C., additional, Castilho, L., additional, Kaufman, R. M., additional, Colling, M. E., additional, Perseghin, P., additional, Incontri, A., additional, Dassi, M., additional, Brilhante, D., additional, Macédo, A., additional, Cserti-Gazdewich, C., additional, Pendergrast, J. M., additional, Hawes, J., additional, Lundgren, M. N., additional, Storry, J. R., additional, Jain, A., additional, Marwaha, N., additional, and Sharma, R. R., additional

Published
2018
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38. Vox Sanguinis International Forum on typing and matching strategies in patients on anti-CD38 monoclonal therapy: summary

Author

de Vooght, K. M. K., primary, Lozano, M., additional, Bueno, J-L., additional, Alarcón, A., additional, Romera, I., additional, Suzuki, K., additional, Zhiburt, E., additional, Holbro, A., additional, Infanti, L., additional, Buser, A., additional, Hustinx, H., additional, Deneys, V., additional, Frélik, A., additional, Thiry, C., additional, Murphy, M., additional, Staves, J., additional, Selleng, K., additional, Greinacher, A., additional, Kutner, J.M., additional, Bonet Bub, C., additional, Castilho, L., additional, Kaufman, R., additional, Colling, M.E., additional, Perseghin, P., additional, Incontri, A., additional, Dassi, M., additional, Brilhante, D., additional, Macêdo, A., additional, Cserti-Gazdewich, C., additional, Pendergrast, J.M., additional, Hawes, J., additional, Lundgren, M.N., additional, Storry, J.R., additional, Jain, A., additional, Marwaha, N., additional, and Sharma, R.R., additional

Published
2018
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40. International Forum on typing and matching strategies in patients on anti-CD38 monoclonal therapy

Author

De Vooght, K. M.K., Lozano, M., Bueno, J. L., Alarcón, A., Romera, I., Suzuki, K., Zhiburt, E., Holbro, A., Infanti, L., Buser, A., Hustinx, H., Deneys, V., Frélik, A., Thiry, C., Murphy, M., Staves, J., Selleng, K., Greinacher, A., Kutner, J. M., Bonet Bub, C., Castilho, L., Kaufman, R. M., Colling, M. E., Perseghin, P., Incontri, A., Dassi, M., Brilhante, D., Macédo, A., Cserti-Gazdewich, C., Pendergrast, J. M., Hawes, J., Lundgren, M. N., Storry, J. R., Jain, A., Marwaha, N., Sharma, R. R., De Vooght, K. M.K., Lozano, M., Bueno, J. L., Alarcón, A., Romera, I., Suzuki, K., Zhiburt, E., Holbro, A., Infanti, L., Buser, A., Hustinx, H., Deneys, V., Frélik, A., Thiry, C., Murphy, M., Staves, J., Selleng, K., Greinacher, A., Kutner, J. M., Bonet Bub, C., Castilho, L., Kaufman, R. M., Colling, M. E., Perseghin, P., Incontri, A., Dassi, M., Brilhante, D., Macédo, A., Cserti-Gazdewich, C., Pendergrast, J. M., Hawes, J., Lundgren, M. N., Storry, J. R., Jain, A., Marwaha, N., and Sharma, R. R.

Published
2018

41. International Forum on typing and matching strategies in patients on anti-CD38 monoclonal therapy

Author

CDL Staf Patiëntenzorg KC, Other research (not in main researchprogram), De Vooght, K. M.K., Lozano, M., Bueno, J. L., Alarcón, A., Romera, I., Suzuki, K., Zhiburt, E., Holbro, A., Infanti, L., Buser, A., Hustinx, H., Deneys, V., Frélik, A., Thiry, C., Murphy, M., Staves, J., Selleng, K., Greinacher, A., Kutner, J. M., Bonet Bub, C., Castilho, L., Kaufman, R. M., Colling, M. E., Perseghin, P., Incontri, A., Dassi, M., Brilhante, D., Macédo, A., Cserti-Gazdewich, C., Pendergrast, J. M., Hawes, J., Lundgren, M. N., Storry, J. R., Jain, A., Marwaha, N., Sharma, R. R., CDL Staf Patiëntenzorg KC, Other research (not in main researchprogram), De Vooght, K. M.K., Lozano, M., Bueno, J. L., Alarcón, A., Romera, I., Suzuki, K., Zhiburt, E., Holbro, A., Infanti, L., Buser, A., Hustinx, H., Deneys, V., Frélik, A., Thiry, C., Murphy, M., Staves, J., Selleng, K., Greinacher, A., Kutner, J. M., Bonet Bub, C., Castilho, L., Kaufman, R. M., Colling, M. E., Perseghin, P., Incontri, A., Dassi, M., Brilhante, D., Macédo, A., Cserti-Gazdewich, C., Pendergrast, J. M., Hawes, J., Lundgren, M. N., Storry, J. R., Jain, A., Marwaha, N., and Sharma, R. R.

Published
2018

43. Prophylactic platelet transfusions

Author

Pietersz, R, Reesink, H, Panzer, S, Gilbertson, M, Borosak, M, Wood, E, Leitner, G, Rabitsch, W, Ay, C, Lambermont, M, Deneys, V, Sondag, D, Compernolle, V, Legrand, D, François, A, Tardivel, R, Garban, F, Sawant, R, Rebulla, P, Handa, M, Ohto, H, Kerkhoffs, J, Brand, A, Zhiburt, E, and Cid, J

Published
2016

45. Recommendations in the event of a suspected transfusion-related acute lung injury (trali)

Author

Van der Linden, P., Lambermont, M., Dierick, A., Hubner, R., Benoit, Y., De Backer, D., de Paep, Rudi, Ferrant, A., Latinne, D., Muylle, Ludo, Selleslag, D., Szabo, B., Thomas, I, Vandekerckhove, B., and Deneys, V.

Subjects
Human medicine
Abstract

The following recommendations, which aim at improving the clinical diagnosis of TRALI and the laboratory investigations that can support it, were drawn up by a working group of the Superior Health Council. TRALI is a complication of blood transfusion that is both serious and under-reported. Systematic reporting may help to develop preventive actions. Therefore, the Superior Health Council recommends that there should be a more stringent surveillance of patients who receive a blood component transfusion. The clinician should pay very close attention to any change in the patient's respiratory status (cf. dyspnoea and arterial desaturation), which should be notified systematically to the haemovigilance contact person in the hospital.

Published
2012

47. Zwangerschap en trombose

Author

Gaston Baele, Jl David, Michel De Maeseneer, Deneys, V., Ma Dicato, Gilis, L., Hainaut, P., Hermans, C., Kristin Jochmans, Serge Motte, Planken, M., Verhaeghe, R., Vermylen, J., Kemp, K., Jc Wautrecht, Zicot, M., Anatomisch Onderzoek en Klinische Studies, Kinesitherapie, Menselijke Fysiologie en Anatomie, Ondersteunende Klinische wetenschappen, Radiologie, and Immunologie en Microbiologie

Subjects
zwangerschap, Thrombosis, pregnancy, trombose
Abstract

not available

Published
2002

50. Belgian consensus recommendations for flow cytometric immunophenotyping. The Belgian Association for Cytometry/Belgische Vereniging voor Cytometrie/Association Belge de Cytométrie

Author

Dr, Bockstaele, Deneys V, jan philippé, Bernier M, Kestens L, Chatelain B, De Waele M, Demanet C, Immunology and Microbiology, Hematology, and Pathology/molecular and cellular medicine

Subjects
Acquired Immunodeficiency Syndrome, Lymphoma, Non-Hodgkin, Hemoglobinuria, Paroxysmal, leukemia, Paraproteinemias, Anemia, Aplastic, Hematopoietic Stem Cells, Flow Cytometry, Lymphoproliferative Disorders, myelodysplastic syndromes, CD4 Lymphocyte Count, Immunophenotyping, Belgium, Hematologic Neoplasms, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Acute Disease, LYMPHOMA, hematopoïetic stem cells, Humans, health care economics and organizations, cell count
Abstract

This paper summarises the guidelines and recommendations that were generated during a number of discussion forums attended by the majority of Belgian cytometry laboratory professionals. These forums focused on the rational and optimal use of flow cytometric evaluations in the clinical laboratory setting. The aim was to improve the coherence of the testing panels and the quality of the results and--as such--the clinical diagnostic information. It was also the aim to provide the Belgian prescribing physician and interested laymen with an updated overview of the flow cytometric possibilities. Emphasis is placed on immunophenotyping of haematological malignancies, hematopoietic progenitor cell counting and follow-up of the viral infection caused by the human immunodeficiency virus.

Published
1999

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