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4. ISSLS PRIZE in Basic Science 2024: superiority of nucleus pulposus cell- versus mesenchymal stromal cell-derived extracellular vesicles in attenuating disc degeneration and alleviating pain

Author

Ambrosio, Luca, Schol, Jordy, Ruiz-Fernandez, Clara, Tamagawa, Shota, Soma, Hazuki, Tilotta, Veronica, Di Giacomo, Giuseppina, Cicione, Claudia, Nakayama, Shunya, Kamiya, Kosuke, Papalia, Rocco, Sato, Masato, Vadalà, Gianluca, Watanabe, Masahiko, Denaro, Vincenzo, and Sakai, Daisuke

Published
2024
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7. Cervical Spondylotic Myelopathy

Author

Denaro, Vincenzo, Berton, Alessandra, De Salvatore, Sergio, Longo, Umile Giuseppe, Denaro, Luca, Longo, Umile Giuseppe, editor, and Denaro, Vincenzo, editor

Published
2023
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17. Foot and Ankle Anatomy

Author

Stelitano, Giovanna, Candela, Vincenzo, Di Naro, Calogero, Casciaro, Carlo, Longo, Giuseppi, Denaro, Vincenzo, Lane, John G., editor, Gobbi, Alberto, editor, Espregueira-Mendes, João, editor, Kaleka, Camila Cohen, editor, and Adachi, Nobuo, editor

Published
2023
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28. Scapular Dyskinesis

Author

Longo, Umile Giuseppe, primary, Ambrogioni, Laura Risi, additional, De Salvatore, Sergio, additional, and Denaro, Vincenzo, additional

Published
2023
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30. Rotator Cuff Injuries in Throwing Athletes

Author

Longo, Umile Giuseppe, Stelitano, Giovanna, Candela, Vincenzo, Denaro, Vincenzo, Canata, Gian Luigi, editor, D'Hooghe, Pieter, editor, Hunt, Kenneth J., editor, M. M. J. Kerkhoffs, Gino, editor, and Longo, Umile Giuseppe, editor

Published
2022
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31. Outcomes

Author

Candela, Vincenzo, Stelitano, Giovanna, De Salvatore, Sergio, Casciaro, Carlo, Di Naro, Calogero, Risi Ambrogioni, Laura, Longo, Umile Giuseppe, Denaro, Vincenzo, Longo, Umile Giuseppe, editor, Budhiparama, Nicolaas C., editor, Lustig, Sébastien, editor, Becker, Roland, editor, and Espregueira-Mendes, João, editor

Published
2022
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32. Two-Stage Revision Arthroplasty for Periprosthetic Knee Infection

Author

Longo, Umile Giuseppe, De Salvatore, Sergio, Candela, Vincenzo, Stelitano, Giovanna, Di Naro, Calogero, Casciaro, Carlo, Risi Ambrogioni, Laura, Denaro, Vincenzo, Longo, Umile Giuseppe, editor, Budhiparama, Nicolaas C., editor, Lustig, Sébastien, editor, Becker, Roland, editor, and Espregueira-Mendes, João, editor

Published
2022
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33. Imaging

Author

Candela, Vincenzo, De Salvatore, Sergio, Di Naro, Calogero, Stelitano, Giovanna, Casciaro, Carlo, Risi Ambrogioni, Laura, Longo, Umile Giuseppe, Denaro, Vincenzo, Longo, Umile Giuseppe, editor, Budhiparama, Nicolaas C., editor, Lustig, Sébastien, editor, Becker, Roland, editor, and Espregueira-Mendes, João, editor

Published
2022
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34. General and Local Symptoms of Infection in Knee Replacement

Author

Stelitano, Giovanna, Risi Ambrogioni, Laura, Di Naro, Calogero, Candela, Vincenzo, Casciaro, Carlo, Longo, Umile Giuseppe, Denaro, Vincenzo, Longo, Umile Giuseppe, editor, Budhiparama, Nicolaas C., editor, Lustig, Sébastien, editor, Becker, Roland, editor, and Espregueira-Mendes, João, editor

Published
2022
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39. Effective Prevention and Rehabilitation Strategies to Mitigate Non-Contact Anterior Cruciate Ligament Injuries: A Narrative Review.

Author

Franco, Domenico, Ambrosio, Luca, Za, Pierangelo, Maltese, Girolamo, Russo, Fabrizio, Vadalà, Gianluca, Papalia, Rocco, and Denaro, Vincenzo

Subjects
ANTERIOR cruciate ligament injuries, SPORTS re-entry, ANTERIOR cruciate ligament surgery, SPORTS medicine, STRENGTH training, PLYOMETRICS
Abstract

Non-contact anterior cruciate ligament injuries (NC-ACLs) represent a significant concern in sports medicine, particularly among athletes and physically active individuals. These injuries not only result in immediate functional impairment but also predispose individuals to long-term issues such as recurrent instability and early-onset osteoarthritis. This narrative review examines the biomechanical, neuromuscular, and environmental factors that contribute to the high incidence of NC-ACLs and evaluates the effectiveness of current prevention and rehabilitation strategies. The review identifies key risk factors, including improper landing mechanics, deficits in neuromuscular control, and muscle imbalances, which are pivotal in the etiology of NC-ACLs. Prevention programs that incorporate plyometric exercises, strength training, and neuromuscular education have shown efficacy in reducing injury rates. Rehabilitation protocols that emphasize a gradual return to sport, focusing on pain management, restoration of range of motion, and progressive strengthening, are critical for successful recovery and prevention of re-injury. The evidence suggests that an integrated approach, combining prevention and rehabilitation strategies tailored to the individual, is essential for minimizing NC-ACL risk and improving outcomes in affected populations. [ABSTRACT FROM AUTHOR]

Published
2024
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40. High-fiber diet reduces bone formation but does not affect bone microarchitecture in type 2 diabetes individuals.

Author

Faraj, Malak, Leanza, Giulia, Krug, Johannes, Cannata, Francesca, Viola, Viola, Zampogna, Biagio, Russo, Fabrizio, Banfi, Giuseppe, Lombardi, Giovanni, Vadalà, Gianluca, Mangiavini, Laura, Papalia, Rocco, Denaro, Vincenzo, Busse, Björn, and Napoli, Nicola

Subjects
HIGH-fiber diet, BONE health, TYPE 2 diabetes, WNT genes, BONE growth, DIETARY fiber
Abstract

Bone fragility is a recognized complication of type 2 diabetes mellitus (T2DM), increasing patient morbidity. Thus, the development of an effective intervention to prevent diabetic bone fragility is urgently needed. As lifestyle intervention represents an effective option for diabetes management, it may have an impact on bone health. While studies have shown a beneficial effect of dietary fiber in T2DM management, its effect on bone health is still unclear. Thus, we investigated the impact of a high-fiber diet on bone and glucose control in men and women with T2DM. Forty-five T2DM patients (HbA1c: 6.5% ± 0.49%, age: 74 ± 7.29 yr) scheduled for hip arthroplasty were randomly assigned to follow a high-fiber diet (38 g/day) or to make no diet changes for 12 wk. Interestingly, BMI decreased by 4% (p <.0001) and HbA1c by 3.4% (p <.0001) in the high-fiber diet group, but did not decrease in the control group. However, serum concentration of the bone formation marker procollagen type 1 amino-terminal propeptide (P1NP) decreased by 8.6 % in the high-fiber diet group (p =.0004), whereas it remained unchanged in the control group. In contrast, similar to the control group, serum concentration of the bone resorption marker C-terminal telopeptide of type I collagen (CTX) concentrations did not change in the high-fiber diet group. Bone microCT analysis revealed no changes in trabecular and cortical bone parameters between the high-fiber diet and control groups. Similarly, real-time (RT)-PCR analysis in bone tissue showed no changes in the gene expression of Wnt pathway-related genes (Sost, Dkk-1, Wnt10b, and Lef-1), bone formation markers (Runx2, Col1a1, and Ocn), and inflammatory cytokines (IL-6, IL-8, TNF-α, and IL-10) between the two groups. Our findings suggest that 12-wk high-fiber diet intervention improves metabolic outcomes in patients with T2DM. However, it may reduce bone formation without affecting bone microarchitecture or Wnt pathway regulation. Lay Summary: The development of effective interventions to prevent diabetic bone fragility is crucial. While the benefits of dietary fiber on T2DM have been widely demonstrated, its effect on bone health is still unclear. Thus, we investigated the impact of 12 wk of high-fiber intake on bone in men and women with T2DM. Although we observed improvements in metabolic outcomes, the high-fiber diet also reduced the bone formation marker P1NP in patients with T2DM. However, these changes did not result in alterations in bone microarchitecture or regulation of the Wnt pathway. Graphical Abstract [ABSTRACT FROM AUTHOR]

Published
2024
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42. FEA Applications for Orthopedics: An Overview

Author

Longo, Umile Giuseppe, Stelitano, Giovanna, Salvatore, Giuseppe, Candela, Vincenzo, Di Naro, Calogero, Ambrogioni, Laura Risi, Amirouche, Farid, Denaro, Vincenzo, Koh, Jason, editor, Zaffagnini, Stefano, editor, Kuroda, Ryosuke, editor, Longo, Umile Giuseppe, editor, and Amirouche, Farid, editor

Published
2021
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43. Biomechanics of the Throwing Shoulder

Author

Fritch, John, Parekh, Amit, Labbe, Andre, Courseault, Jacques, Savoie, Felix, Longo, Umile Giuseppe, De Salvatore, Sergio, Candela, Vincenzo, Di Naro, Calogero, Casciaro, Carlo, Denaro, Vincenzo, Koh, Jason, editor, Zaffagnini, Stefano, editor, Kuroda, Ryosuke, editor, Longo, Umile Giuseppe, editor, and Amirouche, Farid, editor

Published
2021
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44. Tendon Biomechanics-Structure and Composition

Author

Zaffagnini, Stefano, Koh, Jason, Longo, Umile Giuseppe, Stelitano, Giovanna, Amirouche, Farid, Denaro, Vincenzo, Koh, Jason, editor, Zaffagnini, Stefano, editor, Kuroda, Ryosuke, editor, Longo, Umile Giuseppe, editor, and Amirouche, Farid, editor

Published
2021
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