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2. Exposure to bisphenol A in European women from 2007 to 2014 using human biomonitoring data – The European Joint Programme HBM4EU

Author

Tagne-Fotso, Romuald, Riou, Margaux, Saoudi, Abdessattar, Zeghnoun, Abdelkrim, Frederiksen, Hanne, Berman, Tamar, Montazeri, Parisa, Andersson, Anna-Maria, Rodriguez-Martin, Laura, Akesson, Agneta, Berglund, Marika, Biot, Pierre, Castaño, Argelia, Charles, Marie-Aline, Cocco, Emmanuelle, Den Hond, Elly, Dewolf, Marie-Christine, Esteban-Lopez, Marta, Gilles, Liese, Govarts, Eva, Guignard, Cedric, Gutleb, Arno C., Hartmann, Christina, Kold Jensen, Tina, Koppen, Gudrun, Kosjek, Tina, Lambrechts, Nathalie, McEachan, Rosemary, Sakhi, Amrit K., Snoj Tratnik, Janja, Uhl, Maria, Urquiza, Jose, Vafeiadi, Marina, Van Nieuwenhuyse, An, Vrijheid, Martine, Weber, Till, Zaros, Cécile, Tarroja-Aulina, Elena, Knudsen, Lisbeth E., Covaci, Adrian, Barouki, Robert, Kolossa-Gehring, Marike, Schoeters, Greet, Denys, Sebastien, Fillol, Clemence, and Rambaud, Loïc

Published
2024
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3. Urinary phthalate/DINCH metabolites associations with kisspeptin and reproductive hormones in teenagers: A cross-sectional study from the HBM4EU aligned studies

Author

Rodríguez-Carrillo, Andrea, Remy, Sylvie, Koppen, Gudrun, Wauters, Natasha, Mustieles, Vicente, Desalegn, Anteneh, Iszatt, Nina, den Hond, Elly, Verheyen, Veerle J., Fábelová, Lucia, Murinova, Lubica Palkovicova, Pedraza-Díaz, Susana, Esteban, Marta, Poyatos, Rafael M., Govarts, Eva, van Nuijs, Alexander L.N., Covaci, Adrian, Schoeters, Greet, Olea, Nicolás, and Fernández, Mariana F.

Published
2024
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6. Association of exposure to perfluoroalkyl substances (PFAS) and phthalates with thyroid hormones in adolescents from HBM4EU aligned studies

Author

Rodríguez-Carrillo, Andrea, Salamanca-Fernández, Elena, den Hond, Elly, Verheyen, Veerle J., Fábelová, Lucia, Murinova, Lubica Palkovicova, Pedraza-Díaz, Susana, Castaño, Argelia, García-Lario, José Vicente, Remy, Sylvie, Govarts, Eva, Schoeters, Greet, Olea, Nicolás, Freire, Carmen, and Fernández, Mariana F.

Published
2023
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7. PFAS association with kisspeptin and sex hormones in teenagers of the HBM4EU aligned studies

Author

Rodríguez-Carrillo, Andrea, Remy, Sylvie, Koppen, Gudrun, Wauters, Natasha, Freire, Carmen, Olivas-Martínez, Alicia, Schillemans, Tessa, Åkesson, Agneta, Desalegn, Anteneh, Iszatt, Nina, den Hond, Elly, Verheyen, Veerle, Fábelová, Lucia, Murinova, Lubica Palkovicova, Pedraza-Díaz, Susana, Castaño, Argelia, García-Lario, José Vicente, Cox, Bianca, Govarts, Eva, Baken, Kirsten, Tena-Sempere, Manuel, Olea, Nicolás, Schoeters, Greet, and Fernández, Mariana F.

Published
2023
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8. Per- and polyfluoroalkyl substances (PFAS) and neurobehavioral function and cognition in adolescents (2010–2011) and elderly people (2014): results from the Flanders Environment and Health Studies (FLEHS)

Author

van Larebeke, Nicolas, Koppen, Gudrun, Decraemer, Sam, Colles, Ann, Bruckers, Liesbeth, Den Hond, Elly, Govarts, Eva, Morrens, Bert, Schettgen, Thomas, Remy, Sylvie, Coertjens, Dries, Nawrot, Tim, Nelen, Vera, Baeyens, Willy, and Schoeters, Greet

Published
2022
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9. Information needs of parents of children with congenital anomalies across Europe: a EUROlinkCAT survey

Author

Marcus, Elena, Latos-Bielenska, Anna, Jamry-Dziurla, Anna, Barišić, Ingeborg, Cavero-Carbonell, Clara, Den Hond, Elly, Garne, Ester, Genard, Lucas, Santos, Ana João, Lutke, LRenée, Matias Dias, Carlos, Neergaard Pedersen, Christina, Neville, Amanda J., Niemann, Annika, Odak, Ljubica, Pierini, Anna, Rico, Juan, Rissmann, Anke, Rankin, Judith, and Morris, Joan K.

Published
2022
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10. PFAS and Phthalate/DINCH Exposure in Association with Age at Menarche in Teenagers of the HBM4EU Aligned Studies

Author

Cox, Bianca, primary, Wauters, Natasha, additional, Rodríguez-Carrillo, Andrea, additional, Portengen, Lützen, additional, Gerofke, Antje, additional, Kolossa-Gehring, Marike, additional, Lignell, Sanna, additional, Lindroos, Anna Karin, additional, Fabelova, Lucia, additional, Murinova, Lubica Palkovicova, additional, Desalegn, Anteneh, additional, Iszatt, Nina, additional, Schillemans, Tessa, additional, Åkesson, Agneta, additional, Colles, Ann, additional, Den Hond, Elly, additional, Koppen, Gudrun, additional, Van Larebeke, Nicolas, additional, Schoeters, Greet, additional, Govarts, Eva, additional, and Remy, Sylvie, additional

Published
2023
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15. Harmonized human biomonitoring in European children, teenagers and adults: EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014–2021)

Author

Govarts, Eva, primary, Gilles, Liese, additional, Rodriguez Martin, Laura, additional, Santonen, Tiina, additional, Apel, Petra, additional, Alvito, Paula, additional, Anastasi, Elena, additional, Andersen, Helle Raun, additional, Andersson, Anna-Maria, additional, Andryskova, Lenka, additional, Antignac, Jean-Philippe, additional, Appenzeller, Brice, additional, Barbone, Fabio, additional, Barnett-Itzhaki, Zohar, additional, Barouki, Robert, additional, Berman, Tamar, additional, Bil, Wieneke, additional, Borges, Teresa, additional, Buekers, Jurgen, additional, Cañas-Portilla, Ana, additional, Covaci, Adrian, additional, Csako, Zsofia, additional, Den Hond, Elly, additional, Dvorakova, Darina, additional, Fabelova, Lucia, additional, Fletcher, Tony, additional, Frederiksen, Hanne, additional, Gabriel, Catherine, additional, Ganzleben, Catherine, additional, Göen, Thomas, additional, Halldorsson, Thorhallur I., additional, Haug, Line S., additional, Horvat, Milena, additional, Huuskonen, Pasi, additional, Imboden, Medea, additional, Jagodic Hudobivnik, Marta, additional, Janasik, Beata, additional, Janev Holcer, Natasa, additional, Karakitsios, Spyros, additional, Katsonouri, Andromachi, additional, Klanova, Jana, additional, Kokaraki, Venetia, additional, Kold Jensen, Tina, additional, Koponen, Jani, additional, Laeremans, Michelle, additional, Laguzzi, Federica, additional, Lange, Rosa, additional, Lemke, Nora, additional, Lignell, Sanna, additional, Lindroos, Anna Karin, additional, Lobo Vicente, Joana, additional, Luijten, Mirjam, additional, Makris, Konstantinos C., additional, Mazej, Darja, additional, Melymuk, Lisa, additional, Meslin, Matthieu, additional, Mol, Hans, additional, Montazeri, Parisa, additional, Murawski, Aline, additional, Namorado, Sónia, additional, Niemann, Lars, additional, Nübler, Stefanie, additional, Nunes, Baltazar, additional, Olafsdottir, Kristin, additional, Palkovicova Murinova, Lubica, additional, Papaioannou, Nafsika, additional, Pedraza-Diaz, Susana, additional, Piler, Pavel, additional, Plichta, Veronika, additional, Poteser, Michael, additional, Probst-Hensch, Nicole, additional, Rambaud, Loïc, additional, Rauscher-Gabernig, Elke, additional, Rausova, Katarina, additional, Remy, Sylvie, additional, Riou, Margaux, additional, Rosolen, Valentina, additional, Rousselle, Christophe, additional, Rüther, Maria, additional, Sarigiannis, Denis, additional, Silva, Maria J., additional, Šlejkovec, Zdenka, additional, Snoj Tratnik, Janja, additional, Stajnko, Anja, additional, Szigeti, Tamas, additional, Tarazona, José V., additional, Thomsen, Cathrine, additional, Tkalec, Žiga, additional, Tolonen, Hanna, additional, Trnovec, Tomas, additional, Uhl, Maria, additional, Van Nieuwenhuyse, An, additional, Vasco, Elsa, additional, Verheyen, Veerle J., additional, Viegas, Susana, additional, Vinggaard, Anne Marie, additional, Vogel, Nina, additional, Vorkamp, Katrin, additional, Wasowicz, Wojciech, additional, Weber, Till, additional, Wimmerova, Sona, additional, Woutersen, Marjolijn, additional, Zimmermann, Philipp, additional, Zvonar, Martin, additional, Koch, Holger, additional, Kolossa-Gehring, Marike, additional, Esteban López, Marta, additional, Castaño, Argelia, additional, Stewart, Lorraine, additional, Sepai, Ovnair, additional, and Schoeters, Greet, additional

Published
2023
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16. Exposure to Phthalates in European Children, Adolescents and Adults since 2005: A Harmonized Approach Based on Existing HBM Data in the HBM4EU Initiative

Author

Vogel, Nina, primary, Lange, Rosa, additional, Schmidt, Phillipp, additional, Rodriguez Martin, Laura, additional, Remy, Sylvie, additional, Springer, Andrea, additional, Puklová, Vladimíra, additional, Černá, Milena, additional, Rudnai, Péter, additional, Középesy, Szilvia, additional, Janasik, Beata, additional, Ligocka, Danuta, additional, Fábelová, Lucia, additional, Kolena, Branislav, additional, Petrovicova, Ida, additional, Jajcaj, Michal, additional, Eštóková, Milada, additional, Esteban-Lopez, Marta, additional, Castaño, Argelia, additional, Tratnik, Janja Snoj, additional, Stajnko, Anja, additional, Knudsen, Lisbeth E., additional, Toppari, Jorma, additional, Main, Katharina M., additional, Juul, Anders, additional, Andersson, Anna-Maria, additional, Jørgensen, Niels, additional, Frederiksen, Hanne, additional, Thomsen, Cathrine, additional, Sakhi, Amrit Kaur, additional, Åkesson, Agneta, additional, Hartmann, Christina, additional, Dewolf, Marie Christine, additional, Koppen, Gudrun, additional, Biot, Pierre, additional, Den Hond, Elly, additional, Voorspoels, Stefan, additional, Gilles, Liese, additional, Govarts, Eva, additional, Murawski, Aline, additional, Gerofke, Antje, additional, Weber, Till, additional, Rüther, Maria, additional, Gutleb, Arno C., additional, Guignard, Cedric, additional, Berman, Tamar, additional, Koch, Holger M., additional, and Kolossa-Gehring, Marike, additional

Published
2023
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17. Human urinary arsenic species, associated exposure determinants and potential health risks assessed in the HBM4EU Aligned Studies

Author

Buekers, Jurgen, primary, Baken, Kirsten, additional, Govarts, Eva, additional, Martin, Laura Rodriguez, additional, Vogel, Nina, additional, Kolossa-Gehring, Marike, additional, Šlejkovec, Zdenka, additional, Falnoga, Ingrid, additional, Horvat, Milena, additional, Lignell, Sanna, additional, Lindroos, Anna Karin, additional, Rambaud, Loïc, additional, Riou, Margaux, additional, Pedraza-Diaz, Susana, additional, Esteban-Lopez, Marta, additional, Castaño, Argelia, additional, Den Hond, Elly, additional, Baeyens, Willy, additional, Santonen, Tiina, additional, and Schoeters, Greet, additional

Published
2023
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18. From science to policy: How European HBM indicators help to answer policy questions related to phthalates and DINCH exposure

Author

IRAS OH Epidemiology Chemical Agents, Gerofke, Antje, David, Madlen, Schmidt, Phillipp, Vicente, Joana Lobo, Buekers, Jurgen, Gilles, Liese, Colles, Ann, Bessems, Jos, Bastiaensen, Michiel, Covaci, Adrian, Den Hond, Elly, Koppen, Gudrun, Laeremans, Michelle, Verheyen, Veerle J, Černá, Milena, Klánová, Jana, Krsková, Andrea, Zvonař, Martin, Knudsen, Lisbeth E, Koch, Holger M, Jensen, Tina Kold, Rambaud, Loïc, Riou, Margaux, Vogel, Nina, Gabriel, Catherine, Karakitsios, Spyros, Papaioannou, Nafsika, Sarigiannis, Denis, Kakucs, Réka, Középesy, Szilvia, Rudnai, Péter, Szigeti, Tamás, Barbone, Fabio, Rosolen, Valentina, Guignard, Cedric, Gutleb, Arno C, Sakhi, Amrit Kaur, Haug, Line Småstuen, Janasik, Beata, Ligocka, Danuta, Estokova, Milada, Fabelova, Lucia, Kolena, Branislav, Murinova, Lubica Palkovicova, Petrovicova, Ida, Richterova, Denisa, Horvat, Milena, Mazej, Darja, Tratnik, Janja Snoj, Runkel, Agneta Annika, Castaño, Argelia, Esteban-López, Marta, Pedraza-Díaz, Susana, Åkesson, Agneta, Lignell, Sanna, Vlaanderen, Jelle, Zock, Jan-Paul, Schoeters, Greet, Kolossa-Gehring, Marike, IRAS OH Epidemiology Chemical Agents, Gerofke, Antje, David, Madlen, Schmidt, Phillipp, Vicente, Joana Lobo, Buekers, Jurgen, Gilles, Liese, Colles, Ann, Bessems, Jos, Bastiaensen, Michiel, Covaci, Adrian, Den Hond, Elly, Koppen, Gudrun, Laeremans, Michelle, Verheyen, Veerle J, Černá, Milena, Klánová, Jana, Krsková, Andrea, Zvonař, Martin, Knudsen, Lisbeth E, Koch, Holger M, Jensen, Tina Kold, Rambaud, Loïc, Riou, Margaux, Vogel, Nina, Gabriel, Catherine, Karakitsios, Spyros, Papaioannou, Nafsika, Sarigiannis, Denis, Kakucs, Réka, Középesy, Szilvia, Rudnai, Péter, Szigeti, Tamás, Barbone, Fabio, Rosolen, Valentina, Guignard, Cedric, Gutleb, Arno C, Sakhi, Amrit Kaur, Haug, Line Småstuen, Janasik, Beata, Ligocka, Danuta, Estokova, Milada, Fabelova, Lucia, Kolena, Branislav, Murinova, Lubica Palkovicova, Petrovicova, Ida, Richterova, Denisa, Horvat, Milena, Mazej, Darja, Tratnik, Janja Snoj, Runkel, Agneta Annika, Castaño, Argelia, Esteban-López, Marta, Pedraza-Díaz, Susana, Åkesson, Agneta, Lignell, Sanna, Vlaanderen, Jelle, Zock, Jan-Paul, Schoeters, Greet, and Kolossa-Gehring, Marike

Published
2023

19. Harmonized human biomonitoring in European children, teenagers and adults:EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014-2021)

Author

Govarts, Eva, Gilles, Liese, Rodriguez Martin, Laura, Santonen, Tiina, Apel, Petra, Alvito, Paula, Anastasi, Elena, Andersen, Helle Raun, Andersson, Anna-Maria, Andryskova, Lenka, Antignac, Jean-Philippe, Appenzeller, Brice, Barbone, Fabio, Barnett-Itzhaki, Zohar, Barouki, Robert, Berman, Tamar, Bil, Wieneke, Borges, Teresa, Buekers, Jurgen, Cañas-Portilla, Ana, Covaci, Adrian, Csako, Zsofia, Den Hond, Elly, Dvorakova, Darina, Fabelova, Lucia, Fletcher, Tony, Frederiksen, Hanne, Gabriel, Catherine, Ganzleben, Catherine, Göen, Thomas, Halldorsson, Thorhallur I, Haug, Line S, Horvat, Milena, Huuskonen, Pasi, Imboden, Medea, Jagodic Hudobivnik, Marta, Janasik, Beata, Janev Holcer, Natasa, Karakitsios, Spyros, Katsonouri, Andromachi, Klanova, Jana, Kokaraki, Venetia, Kold Jensen, Tina, Koponen, Jani, Laeremans, Michelle, Laguzzi, Federica, Lange, Rosa, Lemke, Nora, Lignell, Sanna, Lindroos, Anna Karin, Lobo Vicente, Joana, Luijten, Mirjam, Makris, Konstantinos C, Mazej, Darja, Melymuk, Lisa, Meslin, Matthieu, Mol, Hans, Montazeri, Parisa, Murawski, Aline, Namorado, Sónia, Niemann, Lars, Nübler, Stefanie, Nunes, Baltazar, Olafsdottir, Kristin, Palkovicova Murinova, Lubica, Papaioannou, Nafsika, Pedraza-Diaz, Susana, Piler, Pavel, Plichta, Veronika, Poteser, Michael, Probst-Hensch, Nicole, Rambaud, Loïc, Rauscher-Gabernig, Elke, Rausova, Katarina, Remy, Sylvie, Riou, Margaux, Rosolen, Valentina, Rousselle, Christophe, Rüther, Maria, Sarigiannis, Denis, Silva, Maria J., Šlejkovec, Zdenka, Snoj Tratnik, Janja, Stajnko, Anja, Szigeti, Tamas, Tarazona, José V., Thomsen, Cathrine, Tkalec, Žiga, Tolonen, Hanna, Trnovec, Tomas, Uhl, Maria, Van Nieuwenhuyse, An, Vasco, Elsa, Verheyen, Veerle J, Viegas, Susana, Vinggaard, Anne Marie, Vogel, Nina, Vorkamp, Katrin, Wasowicz, Wojciech, Weber, Till, Wimmerova, Sona, Woutersen, Marjolijn, Zimmermann, Philipp, Zvonar, Martin, Koch, Holger, Kolossa-Gehring, Marike, Esteban López, Marta, Castaño, Argelia, Stewart, Lorraine, Sepai, Ovnair, Schoeters, Greet, Govarts, Eva, Gilles, Liese, Rodriguez Martin, Laura, Santonen, Tiina, Apel, Petra, Alvito, Paula, Anastasi, Elena, Andersen, Helle Raun, Andersson, Anna-Maria, Andryskova, Lenka, Antignac, Jean-Philippe, Appenzeller, Brice, Barbone, Fabio, Barnett-Itzhaki, Zohar, Barouki, Robert, Berman, Tamar, Bil, Wieneke, Borges, Teresa, Buekers, Jurgen, Cañas-Portilla, Ana, Covaci, Adrian, Csako, Zsofia, Den Hond, Elly, Dvorakova, Darina, Fabelova, Lucia, Fletcher, Tony, Frederiksen, Hanne, Gabriel, Catherine, Ganzleben, Catherine, Göen, Thomas, Halldorsson, Thorhallur I, Haug, Line S, Horvat, Milena, Huuskonen, Pasi, Imboden, Medea, Jagodic Hudobivnik, Marta, Janasik, Beata, Janev Holcer, Natasa, Karakitsios, Spyros, Katsonouri, Andromachi, Klanova, Jana, Kokaraki, Venetia, Kold Jensen, Tina, Koponen, Jani, Laeremans, Michelle, Laguzzi, Federica, Lange, Rosa, Lemke, Nora, Lignell, Sanna, Lindroos, Anna Karin, Lobo Vicente, Joana, Luijten, Mirjam, Makris, Konstantinos C, Mazej, Darja, Melymuk, Lisa, Meslin, Matthieu, Mol, Hans, Montazeri, Parisa, Murawski, Aline, Namorado, Sónia, Niemann, Lars, Nübler, Stefanie, Nunes, Baltazar, Olafsdottir, Kristin, Palkovicova Murinova, Lubica, Papaioannou, Nafsika, Pedraza-Diaz, Susana, Piler, Pavel, Plichta, Veronika, Poteser, Michael, Probst-Hensch, Nicole, Rambaud, Loïc, Rauscher-Gabernig, Elke, Rausova, Katarina, Remy, Sylvie, Riou, Margaux, Rosolen, Valentina, Rousselle, Christophe, Rüther, Maria, Sarigiannis, Denis, Silva, Maria J., Šlejkovec, Zdenka, Snoj Tratnik, Janja, Stajnko, Anja, Szigeti, Tamas, Tarazona, José V., Thomsen, Cathrine, Tkalec, Žiga, Tolonen, Hanna, Trnovec, Tomas, Uhl, Maria, Van Nieuwenhuyse, An, Vasco, Elsa, Verheyen, Veerle J, Viegas, Susana, Vinggaard, Anne Marie, Vogel, Nina, Vorkamp, Katrin, Wasowicz, Wojciech, Weber, Till, Wimmerova, Sona, Woutersen, Marjolijn, Zimmermann, Philipp, Zvonar, Martin, Koch, Holger, Kolossa-Gehring, Marike, Esteban López, Marta, Castaño, Argelia, Stewart, Lorraine, Sepai, Ovnair, and Schoeters, Greet

Abstract

As one of the core elements of the European Human Biomonitoring Initiative (HBM4EU) a human biomonitoring (HBM) survey was conducted in 23 countries to generate EU-wide comparable HBM data. This survey has built on existing HBM capacity in Europe by aligning national or regional HBM studies, referred to as the HBM4EU Aligned Studies. The HBM4EU Aligned Studies included a total of 10,795 participants of three age groups: (i) 3,576 children aged 6-12 years, (ii) 3,117 teenagers aged 12-18 years and (iii) 4,102 young adults aged 20-39 years. The participants were recruited between 2014 and 2021 in 11-12 countries per age group, geographically distributed across Europe. Depending on the age group, internal exposure to phthalates and the substitute DINCH, halogenated and organophosphorus flame retardants, per- and polyfluoroalkyl substances (PFASs), cadmium, bisphenols, polycyclic aromatic hydrocarbons (PAHs), arsenic species, acrylamide, mycotoxins (deoxynivalenol (total DON)), benzophenones and selected pesticides was assessed by measuring substance specific biomarkers subjected to stringent quality control programs for chemical analysis. For substance groups analyzed in different age groups higher average exposure levels were observed in the youngest age group, i.e., phthalates/DINCH in children versus teenagers, acrylamide and pesticides in children versus adults, benzophenones in teenagers versus adults. Many biomarkers in teenagers and adults varied significantly according to educational attainment, with higher exposure levels of bisphenols, phthalates, benzophenones, PAHs and acrylamide in participants (from households) with lower educational attainment, while teenagers from households with higher educational attainment have higher exposure levels for PFASs and arsenic. In children, a social gradient was only observed for the non-specific pyrethroid metabolite 3-PBA and di-isodecyl phthalate (DiDP), with higher levels in children from households with higher educat

Published
2023

20. Exposure to Phthalates in European Children, Adolescents and Adults since 2005:A Harmonized Approach Based on Existing HBM Data in the HBM4EU Initiative

Author

Vogel, Nina, Lange, Rosa, Schmidt, Phillipp, Rodriguez Martin, Laura, Remy, Sylvie, Springer, Andrea, Puklová, Vladimíra, Černá, Milena, Rudnai, Péter, Középesy, Szilvia, Janasik, Beata, Ligocka, Danuta, Fábelová, Lucia, Kolena, Branislav, Petrovicova, Ida, Jajcaj, Michal, Eštóková, Milada, Esteban-Lopez, Marta, Castaño, Argelia, Tratnik, Janja Snoj, Stajnko, Anja, Knudsen, Lisbeth E., Toppari, Jorma, Main, Katharina M., Juul, Anders, Andersson, Anna Maria, Jørgensen, Niels, Frederiksen, Hanne, Thomsen, Cathrine, Sakhi, Amrit Kaur, Åkesson, Agneta, Hartmann, Christina, Dewolf, Marie Christine, Koppen, Gudrun, Biot, Pierre, Den Hond, Elly, Voorspoels, Stefan, Gilles, Liese, Govarts, Eva, Murawski, Aline, Gerofke, Antje, Weber, Till, Rüther, Maria, Gutleb, Arno C., Guignard, Cedric, Berman, Tamar, Koch, Holger M., Kolossa-Gehring, Marike, Vogel, Nina, Lange, Rosa, Schmidt, Phillipp, Rodriguez Martin, Laura, Remy, Sylvie, Springer, Andrea, Puklová, Vladimíra, Černá, Milena, Rudnai, Péter, Középesy, Szilvia, Janasik, Beata, Ligocka, Danuta, Fábelová, Lucia, Kolena, Branislav, Petrovicova, Ida, Jajcaj, Michal, Eštóková, Milada, Esteban-Lopez, Marta, Castaño, Argelia, Tratnik, Janja Snoj, Stajnko, Anja, Knudsen, Lisbeth E., Toppari, Jorma, Main, Katharina M., Juul, Anders, Andersson, Anna Maria, Jørgensen, Niels, Frederiksen, Hanne, Thomsen, Cathrine, Sakhi, Amrit Kaur, Åkesson, Agneta, Hartmann, Christina, Dewolf, Marie Christine, Koppen, Gudrun, Biot, Pierre, Den Hond, Elly, Voorspoels, Stefan, Gilles, Liese, Govarts, Eva, Murawski, Aline, Gerofke, Antje, Weber, Till, Rüther, Maria, Gutleb, Arno C., Guignard, Cedric, Berman, Tamar, Koch, Holger M., and Kolossa-Gehring, Marike

Abstract

Phthalates are mainly used as plasticizers and are associated inter alia with adverse effects on reproductive functions. While more and more national programs in Europe have started monitoring internal exposure to phthalates and its substitute 1,2-Cyclohexanedicarboxylic acid (DINCH), the comparability of results from such existing human biomonitoring (HBM) studies across Europe is challenging. They differ widely in time periods, study samples, degree of geographical coverage, design, analytical methodology, biomarker selection, and analytical quality assurance level. The HBM4EU initiative has gathered existing HBM data of 29 studies from participating countries, covering all European regions and Israel. The data were prepared and aggregated by a harmonized procedure with the aim to describe—as comparably as possible—the EU-wide general population’s internal exposure to phthalates from the years 2005 to 2019. Most data were available from Northern (up to 6 studies and up to 13 time points), Western (11; 19), and Eastern Europe (9; 12), e.g., allowing for the investigation of time patterns. While the bandwidth of exposure was generally similar, we still observed regional differences for Butyl benzyl phthalate (BBzP), Di(2-ethylhexyl) phthalate (DEHP), Di-isononyl phthalate (DiNP), and Di-isobutyl phthalate (DiBP) with pronounced decreases over time in Northern and Western Europe, and to a lesser degree in Eastern Europe. Differences between age groups were visible for Di-n-butyl phthalate (DnBP), where children (3 to 5-year olds and 6 to 11-year olds) had lower urinary concentrations than adolescents (12 to 19-year-olds), who in turn had lower urinary concentrations than adults (20 to 39-year-olds). This study is a step towards making internal exposures to phthalates comparable across countries, although standardized data were not available, targeting European data sets harmonized with respect to data formatting and calculation of aggregated data (such as develope

Published
2023

21. From science to policy:How European HBM indicators help to answer policy questions related to phthalates and DINCH exposure

Author

Gerofke, Antje, David, Madlen, Schmidt, Phillipp, Vicente, Joana Lobo, Buekers, Jurgen, Gilles, Liese, Colles, Ann, Bessems, Jos, Bastiaensen, Michiel, Covaci, Adrian, Den Hond, Elly, Koppen, Gudrun, Laeremans, Michelle, Verheyen, Veerle J., Černá, Milena, Klánová, Jana, Krsková, Andrea, Zvonař, Martin, Knudsen, Lisbeth E., Koch, Holger M., Jensen, Tina Kold, Rambaud, Loïc, Riou, Margaux, Vogel, Nina, Gabriel, Catherine, Karakitsios, Spyros, Papaioannou, Nafsika, Sarigiannis, Denis, Kakucs, Réka, Középesy, Szilvia, Rudnai, Péter, Szigeti, Tamás, Barbone, Fabio, Rosolen, Valentina, Guignard, Cedric, Gutleb, Arno C., Sakhi, Amrit Kaur, Haug, Line Småstuen, Janasik, Beata, Ligocka, Danuta, Estokova, Milada, Fabelova, Lucia, Kolena, Branislav, Murinova, Lubica Palkovicova, Petrovicova, Ida, Richterova, Denisa, Horvat, Milena, Mazej, Darja, Tratnik, Janja Snoj, Runkel, Agneta Annika, Castaño, Argelia, Esteban-López, Marta, Pedraza-Díaz, Susana, Åkesson, Agneta, Lignell, Sanna, Vlaanderen, Jelle, Zock, Jan Paul, Schoeters, Greet, Kolossa-Gehring, Marike, Gerofke, Antje, David, Madlen, Schmidt, Phillipp, Vicente, Joana Lobo, Buekers, Jurgen, Gilles, Liese, Colles, Ann, Bessems, Jos, Bastiaensen, Michiel, Covaci, Adrian, Den Hond, Elly, Koppen, Gudrun, Laeremans, Michelle, Verheyen, Veerle J., Černá, Milena, Klánová, Jana, Krsková, Andrea, Zvonař, Martin, Knudsen, Lisbeth E., Koch, Holger M., Jensen, Tina Kold, Rambaud, Loïc, Riou, Margaux, Vogel, Nina, Gabriel, Catherine, Karakitsios, Spyros, Papaioannou, Nafsika, Sarigiannis, Denis, Kakucs, Réka, Középesy, Szilvia, Rudnai, Péter, Szigeti, Tamás, Barbone, Fabio, Rosolen, Valentina, Guignard, Cedric, Gutleb, Arno C., Sakhi, Amrit Kaur, Haug, Line Småstuen, Janasik, Beata, Ligocka, Danuta, Estokova, Milada, Fabelova, Lucia, Kolena, Branislav, Murinova, Lubica Palkovicova, Petrovicova, Ida, Richterova, Denisa, Horvat, Milena, Mazej, Darja, Tratnik, Janja Snoj, Runkel, Agneta Annika, Castaño, Argelia, Esteban-López, Marta, Pedraza-Díaz, Susana, Åkesson, Agneta, Lignell, Sanna, Vlaanderen, Jelle, Zock, Jan Paul, Schoeters, Greet, and Kolossa-Gehring, Marike

Abstract

Within the European Human Biomonitoring (HBM) Initiative HBM4EU we derived HBM indicators that were designed to help answering key policy questions and support chemical policies. The result indicators convey information on chemicals exposure of different age groups, sexes, geographical regions and time points by comparing median exposure values. If differences are observed for one group or the other, policy measures or risk management options can be implemented. Impact indicators support health risk assessment by comparing exposure values with health-based guidance values, such as human biomonitoring guidance values (HBM-GVs). In general, the indicators should be designed to translate complex scientific information into short and clear messages and make it accessible to policy makers but also to a broader audience such as stakeholders (e.g. NGO's), other scientists and the general public. Based on harmonized data from the HBM4EU Aligned Studies (2014–2021), the usefulness of our indicators was demonstrated for the age group children (6–11 years), using two case examples: one phthalate (Diisobutyl phthalate: DiBP) and one non-phthalate substitute (Di-isononyl cyclohexane-1,2- dicarboxylate: DINCH). For the comparison of age groups, these were compared to data for teenagers (12–18 years), and time periods were compared using data from the DEMOCOPHES project (2011–2012). Our result indicators proved to be suitable for demonstrating the effectiveness of policy measures for DiBP and the need of continuous monitoring for DINCH. They showed similar exposure for boys and girls, indicating that there is no need for gender focused interventions and/or no indication of sex-specific exposure patterns. They created a basis for a targeted approach by highlighting relevant geographical differences in internal exposure. An adequate data basis is essential for revealing differences for all indicators. This was particularly evident in our studies on the indicators on age differences., Within the European Human Biomonitoring (HBM) Initiative HBM4EU we derived HBM indicators that were designed to help answering key policy questions and support chemical policies. The result indicators convey information on chemicals exposure of different age groups, sexes, geographical regions and time points by comparing median exposure values. If differences are observed for one group or the other, policy measures or risk management options can be implemented. Impact indicators support health risk assessment by comparing exposure values with health-based guidance values, such as human biomonitoring guidance values (HBM-GVs). In general, the indicators should be designed to translate complex scientific information into short and clear messages and make it accessible to policy makers but also to a broader audience such as stakeholders (e.g. NGO's), other scientists and the general public. Based on harmonized data from the HBM4EU Aligned Studies (2014–2021), the usefulness of our indicators was demonstrated for the age group children (6–11 years), using two case examples: one phthalate (Diisobutyl phthalate: DiBP) and one non-phthalate substitute (Di-isononyl cyclohexane-1,2- dicarboxylate: DINCH). For the comparison of age groups, these were compared to data for teenagers (12–18 years), and time periods were compared using data from the DEMOCOPHES project (2011–2012). Our result indicators proved to be suitable for demonstrating the effectiveness of policy measures for DiBP and the need of continuous monitoring for DINCH. They showed similar exposure for boys and girls, indicating that there is no need for gender focused interventions and/or no indication of sex-specific exposure patterns. They created a basis for a targeted approach by highlighting relevant geographical differences in internal exposure. An adequate data basis is essential for revealing differences for all indicators. This was particularly evident in our studies on the indicators on age differenc

Published
2023

22. Harmonized human biomonitoring in European children, teenagers and adults : EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014–2021)

Author

Govarts, Eva, Gilles, Liese, Rodriguez Martin, Laura, Santonen, Tiina, Apel, Petra, Alvito, Paula, Anastasi, Elena, Andersen, Helle Raun, Andersson, Anna Maria, Andryskova, Lenka, Antignac, Jean Philippe, Appenzeller, Brice, Barbone, Fabio, Barnett-Itzhaki, Zohar, Barouki, Robert, Berman, Tamar, Bil, Wieneke, Borges, Teresa, Buekers, Jurgen, Cañas-Portilla, Ana, Covaci, Adrian, Csako, Zsofia, Den Hond, Elly, Dvorakova, Darina, Fabelova, Lucia, Fletcher, Tony, Frederiksen, Hanne, Gabriel, Catherine, Ganzleben, Catherine, Göen, Thomas, Halldorsson, Thorhallur I., Haug, Line S., Horvat, Milena, Huuskonen, Pasi, Imboden, Medea, Jagodic Hudobivnik, Marta, Janasik, Beata, Janev Holcer, Natasa, Karakitsios, Spyros, Katsonouri, Andromachi, Klanova, Jana, Kokaraki, Venetia, Kold Jensen, Tina, Koponen, Jani, Laeremans, Michelle, Laguzzi, Federica, Lange, Rosa, Lemke, Nora, Lignell, Sanna, Lindroos, Anna Karin, Lobo Vicente, Joana, Luijten, Mirjam, Makris, Konstantinos C., Mazej, Darja, Melymuk, Lisa, Meslin, Matthieu, Mol, Hans, Montazeri, Parisa, Murawski, Aline, Namorado, Sónia, Niemann, Lars, Nübler, Stefanie, Nunes, Baltazar, Olafsdottir, Kristin, Palkovicova Murinova, Lubica, Papaioannou, Nafsika, Pedraza-Diaz, Susana, Piler, Pavel, Plichta, Veronika, Poteser, Michael, Probst-Hensch, Nicole, Rambaud, Loïc, Rauscher-Gabernig, Elke, Rausova, Katarina, Remy, Sylvie, Riou, Margaux, Rosolen, Valentina, Rousselle, Christophe, Rüther, Maria, Sarigiannis, Denis, Silva, Maria J., Šlejkovec, Zdenka, Snoj Tratnik, Janja, Stajnko, Anja, Szigeti, Tamas, Tarazona, José V., Thomsen, Cathrine, Tkalec, Žiga, Tolonen, Hanna, Trnovec, Tomas, Uhl, Maria, Van Nieuwenhuyse, An, Vasco, Elsa, Verheyen, Veerle J., Viegas, Susana, Vinggaard, Anne Marie, Vogel, Nina, Vorkamp, Katrin, Wasowicz, Wojciech, Weber, Till, Wimmerova, Sona, Woutersen, Marjolijn, Zimmermann, Philipp, Zvonar, Martin, Koch, Holger, Kolossa-Gehring, Marike, Esteban López, Marta, Castaño, Argelia, Stewart, Lorraine, Sepai, Ovnair, Schoeters, Greet, Govarts, Eva, Gilles, Liese, Rodriguez Martin, Laura, Santonen, Tiina, Apel, Petra, Alvito, Paula, Anastasi, Elena, Andersen, Helle Raun, Andersson, Anna Maria, Andryskova, Lenka, Antignac, Jean Philippe, Appenzeller, Brice, Barbone, Fabio, Barnett-Itzhaki, Zohar, Barouki, Robert, Berman, Tamar, Bil, Wieneke, Borges, Teresa, Buekers, Jurgen, Cañas-Portilla, Ana, Covaci, Adrian, Csako, Zsofia, Den Hond, Elly, Dvorakova, Darina, Fabelova, Lucia, Fletcher, Tony, Frederiksen, Hanne, Gabriel, Catherine, Ganzleben, Catherine, Göen, Thomas, Halldorsson, Thorhallur I., Haug, Line S., Horvat, Milena, Huuskonen, Pasi, Imboden, Medea, Jagodic Hudobivnik, Marta, Janasik, Beata, Janev Holcer, Natasa, Karakitsios, Spyros, Katsonouri, Andromachi, Klanova, Jana, Kokaraki, Venetia, Kold Jensen, Tina, Koponen, Jani, Laeremans, Michelle, Laguzzi, Federica, Lange, Rosa, Lemke, Nora, Lignell, Sanna, Lindroos, Anna Karin, Lobo Vicente, Joana, Luijten, Mirjam, Makris, Konstantinos C., Mazej, Darja, Melymuk, Lisa, Meslin, Matthieu, Mol, Hans, Montazeri, Parisa, Murawski, Aline, Namorado, Sónia, Niemann, Lars, Nübler, Stefanie, Nunes, Baltazar, Olafsdottir, Kristin, Palkovicova Murinova, Lubica, Papaioannou, Nafsika, Pedraza-Diaz, Susana, Piler, Pavel, Plichta, Veronika, Poteser, Michael, Probst-Hensch, Nicole, Rambaud, Loïc, Rauscher-Gabernig, Elke, Rausova, Katarina, Remy, Sylvie, Riou, Margaux, Rosolen, Valentina, Rousselle, Christophe, Rüther, Maria, Sarigiannis, Denis, Silva, Maria J., Šlejkovec, Zdenka, Snoj Tratnik, Janja, Stajnko, Anja, Szigeti, Tamas, Tarazona, José V., Thomsen, Cathrine, Tkalec, Žiga, Tolonen, Hanna, Trnovec, Tomas, Uhl, Maria, Van Nieuwenhuyse, An, Vasco, Elsa, Verheyen, Veerle J., Viegas, Susana, Vinggaard, Anne Marie, Vogel, Nina, Vorkamp, Katrin, Wasowicz, Wojciech, Weber, Till, Wimmerova, Sona, Woutersen, Marjolijn, Zimmermann, Philipp, Zvonar, Martin, Koch, Holger, Kolossa-Gehring, Marike, Esteban López, Marta, Castaño, Argelia, Stewart, Lorraine, Sepai, Ovnair, and Schoeters, Greet

Abstract

As one of the core elements of the European Human Biomonitoring Initiative (HBM4EU) a human biomonitoring (HBM) survey was conducted in 23 countries to generate EU-wide comparable HBM data. This survey has built on existing HBM capacity in Europe by aligning national or regional HBM studies, referred to as the HBM4EU Aligned Studies. The HBM4EU Aligned Studies included a total of 10,795 participants of three age groups: (i) 3,576 children aged 6–12 years, (ii) 3,117 teenagers aged 12–18 years and (iii) 4,102 young adults aged 20–39 years. The participants were recruited between 2014 and 2021 in 11–12 countries per age group, geographically distributed across Europe. Depending on the age group, internal exposure to phthalates and the substitute DINCH, halogenated and organophosphorus flame retardants, per- and polyfluoroalkyl substances (PFASs), cadmium, bisphenols, polycyclic aromatic hydrocarbons (PAHs), arsenic species, acrylamide, mycotoxins (deoxynivalenol (total DON)), benzophenones and selected pesticides was assessed by measuring substance specific biomarkers subjected to stringent quality control programs for chemical analysis. For substance groups analyzed in different age groups higher average exposure levels were observed in the youngest age group, i.e., phthalates/DINCH in children versus teenagers, acrylamide and pesticides in children versus adults, benzophenones in teenagers versus adults. Many biomarkers in teenagers and adults varied significantly according to educational attainment, with higher exposure levels of bisphenols, phthalates, benzophenones, PAHs and acrylamide in participants (from households) with lower educational attainment, while teenagers from households with higher educational attainment have higher exposure levels for PFASs and arsenic. In children, a social gradient was only observed for the non-specific pyrethroid metabolite 3-PBA and di-isodecyl phthalate (DiDP), with higher levels in children from households with higher educat

Published
2023

24. EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014–2021)

Author

Govarts, Eva, Gilles, Liese, Rodriguez Martin, Laura, Santonen, Tiina, Apel, Petra, Alvito, Paula, Anastasi, Elena, Andersen, Helle Raun, Andersson, Anna Maria, Andryskova, Lenka, Antignac, Jean Philippe, Appenzeller, Brice, Barbone, Fabio, Barnett-Itzhaki, Zohar, Barouki, Robert, Berman, Tamar, Bil, Wieneke, Borges, Teresa, Buekers, Jurgen, Cañas-Portilla, Ana, Covaci, Adrian, Csako, Zsofia, Den Hond, Elly, Dvorakova, Darina, Fabelova, Lucia, Fletcher, Tony, Frederiksen, Hanne, Gabriel, Catherine, Ganzleben, Catherine, Göen, Thomas, Halldorsson, Thorhallur I., Haug, Line S., Horvat, Milena, Huuskonen, Pasi, Imboden, Medea, Jagodic Hudobivnik, Marta, Janasik, Beata, Janev Holcer, Natasa, Karakitsios, Spyros, Katsonouri, Andromachi, Klanova, Jana, Kokaraki, Venetia, Kold Jensen, Tina, Koponen, Jani, Laeremans, Michelle, Laguzzi, Federica, Lange, Rosa, Lemke, Nora, Lignell, Sanna, Lindroos, Anna Karin, Lobo Vicente, Joana, Luijten, Mirjam, Makris, Konstantinos C., Mazej, Darja, Melymuk, Lisa, Meslin, Matthieu, Mol, Hans, Montazeri, Parisa, Murawski, Aline, Namorado, Sónia, Niemann, Lars, Nübler, Stefanie, Nunes, Baltazar, Olafsdottir, Kristin, Palkovicova Murinova, Lubica, Papaioannou, Nafsika, Pedraza-Diaz, Susana, Piler, Pavel, Plichta, Veronika, Poteser, Michael, Probst-Hensch, Nicole, Rambaud, Loïc, Rauscher-Gabernig, Elke, Rausova, Katarina, Remy, Sylvie, Riou, Margaux, Rosolen, Valentina, Rousselle, Christophe, Rüther, Maria, Sarigiannis, Denis, Silva, Maria J., Šlejkovec, Zdenka, Snoj Tratnik, Janja, Stajnko, Anja, Szigeti, Tamas, Tarazona, José V., Thomsen, Cathrine, Tkalec, Žiga, Tolonen, Hanna, Trnovec, Tomas, Uhl, Maria, Van Nieuwenhuyse, An, Vasco, Elsa, Verheyen, Veerle J., Viegas, Susana, Vinggaard, Anne Marie, Vogel, Nina, Vorkamp, Katrin, Wasowicz, Wojciech, Weber, Till, Wimmerova, Sona, Woutersen, Marjolijn, Zimmermann, Philipp, Zvonar, Martin, Koch, Holger, Kolossa-Gehring, Marike, Esteban López, Marta, Castaño, Argelia, Stewart, Lorraine, Sepai, Ovnair, Schoeters, Greet, and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Subjects
HBM4EU, SDG 3 - Good Health and Well-being, Public Health, Environmental and Occupational Health, Adults, Exposure biomarkers, Children, Teenagers, Human biomonitoring (HBM)
Abstract

Funding Information: The authors would like to thank everybody who contributed to the HBM4EU Aligned Studies: the participating children, teenagers, adults and their families, the fieldworkers that collected the samples and database managers that made the information available to HBM4EU, the HBM4EU project partners, especially those from WP7 for developing all materials supporting the fieldwork, WP9 for organizing the QA/QC scheme under HBM4EU and all laboratories who performed the analytical measurements. We would like to acknowledge Sun Kyoung Jung from the National Institute of Environmental Research of South-Korea for providing the KoNEHS Cycle III results (crt adjusted). HBM4EU is co-financed under Horizon 2020 (grant agreement No 733032). The authors thank all principal investigators of the contributing studies for their participation and contribution to the HBM4EU Aligned Studies and the national program owners for their financial support. Further details on funding for all the participating studies can be found in the Supplemental Material, Table S12. As one of the core elements of the European Human Biomonitoring Initiative (HBM4EU) a human biomonitoring (HBM) survey was conducted in 23 countries to generate EU-wide comparable HBM data. This survey has built on existing HBM capacity in Europe by aligning national or regional HBM studies, referred to as the HBM4EU Aligned Studies. The HBM4EU Aligned Studies included a total of 10,795 participants of three age groups: (i) 3,576 children aged 6–12 years, (ii) 3,117 teenagers aged 12–18 years and (iii) 4,102 young adults aged 20–39 years. The participants were recruited between 2014 and 2021 in 11–12 countries per age group, geographically distributed across Europe. Depending on the age group, internal exposure to phthalates and the substitute DINCH, halogenated and organophosphorus flame retardants, per- and polyfluoroalkyl substances (PFASs), cadmium, bisphenols, polycyclic aromatic hydrocarbons (PAHs), arsenic species, acrylamide, mycotoxins (deoxynivalenol (total DON)), benzophenones and selected pesticides was assessed by measuring substance specific biomarkers subjected to stringent quality control programs for chemical analysis. For substance groups analyzed in different age groups higher average exposure levels were observed in the youngest age group, i.e., phthalates/DINCH in children versus teenagers, acrylamide and pesticides in children versus adults, benzophenones in teenagers versus adults. Many biomarkers in teenagers and adults varied significantly according to educational attainment, with higher exposure levels of bisphenols, phthalates, benzophenones, PAHs and acrylamide in participants (from households) with lower educational attainment, while teenagers from households with higher educational attainment have higher exposure levels for PFASs and arsenic. In children, a social gradient was only observed for the non-specific pyrethroid metabolite 3-PBA and di-isodecyl phthalate (DiDP), with higher levels in children from households with higher educational attainment. Geographical variations were seen for all exposure biomarkers. For 15 biomarkers, the available health-based HBM guidance values were exceeded with highest exceedance rates for toxicologically relevant arsenic in teenagers (40%), 3-PBA in children (36%), and between 11 and 14% for total DON, Σ (PFOA + PFNA + PFHxS + PFOS), bisphenol S and cadmium. The infrastructure and harmonized approach succeeded in obtaining comparable European wide internal exposure data for a prioritized set of 11 chemical groups. These data serve as a reference for comparison at the global level, provide a baseline to compare the efficacy of the European Commission's chemical strategy for sustainability and will give leverage to national policy makers for the implementation of targeted measures. publishersversion published

Published
2023

25. From science to policy: How European HBM indicators help to answer policy questions related to phthalates and DINCH exposure

Author

Gerofke, Antje, primary, David, Madlen, additional, Schmidt, Phillipp, additional, Vicente, Joana Lobo, additional, Buekers, Jurgen, additional, Gilles, Liese, additional, Colles, Ann, additional, Bessems, Jos, additional, Bastiaensen, Michiel, additional, Covaci, Adrian, additional, Den Hond, Elly, additional, Koppen, Gudrun, additional, Laeremans, Michelle, additional, Verheyen, Veerle J., additional, Černá, Milena, additional, Klánová, Jana, additional, Krsková, Andrea, additional, Zvonař, Martin, additional, Knudsen, Lisbeth E., additional, Koch, Holger M., additional, Jensen, Tina Kold, additional, Rambaud, Loïc, additional, Riou, Margaux, additional, Vogel, Nina, additional, Gabriel, Catherine, additional, Karakitsios, Spyros, additional, Papaioannou, Nafsika, additional, Sarigiannis, Denis, additional, Kakucs, Réka, additional, Középesy, Szilvia, additional, Rudnai, Péter, additional, Szigeti, Tamás, additional, Barbone, Fabio, additional, Rosolen, Valentina, additional, Guignard, Cedric, additional, Gutleb, Arno C., additional, Sakhi, Amrit Kaur, additional, Haug, Line Småstuen, additional, Janasik, Beata, additional, Ligocka, Danuta, additional, Estokova, Milada, additional, Fabelova, Lucia, additional, Kolena, Branislav, additional, Murinova, Lubica Palkovicova, additional, Petrovicova, Ida, additional, Richterova, Denisa, additional, Horvat, Milena, additional, Mazej, Darja, additional, Tratnik, Janja Snoj, additional, Runkel, Agneta Annika, additional, Castaño, Argelia, additional, Esteban-López, Marta, additional, Pedraza-Díaz, Susana, additional, Åkesson, Agneta, additional, Lignell, Sanna, additional, Vlaanderen, Jelle, additional, Zock, Jan-Paul, additional, Schoeters, Greet, additional, and Kolossa-Gehring, Marike, additional

Published
2023
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26. From science to policy : how European HBM indicators help to answer related to and DINCH

Author

Gerofke, Antje, David, Madlen, Schmidt, Phillipp, Vicente, Joana Lobo, Buekers, Jurgen, Gilles, Liese, Colles, Ann, Bessems, Jos, Bastiaensen, Michiel, Covaci, Adrian, Den Hond, Elly, Koppen, Gudrun, Laeremans, Michelle, Verheyen, Veerle J., Cerna, Milena, Klanova, Jana, Krskova, Andrea, Zvonar, Martin, Knudsen, Lisbeth E., Koch, Holger M., Jensen, Tina Kold, Rambaud, Loic, Riou, Margaux, Vogel, Nina, Gabriel, Catherine, Karakitsios, Spyros, Papaioannou, Nafsika, Sarigiannis, Denis, Kakucs, Reka, Kozepesy, Szilvia, Rudnai, Peter, Szigeti, Tamas, Barbone, Fabio, Rosolen, Valentina, Guignard, Cedric, Gutleb, Arno C., Sakhi, Amrit Kaur, Haug, Line Smastuen, Janasik, Beata, Ligocka, Danuta, Estokova, Milada, Fabelova, Lucia, Kolena, Branislav, Murinova, Lubica Palkovicova, Petrovicova, Ida, Richterova, Denisa, Horvat, Milena, Mazej, Darja, Tratnik, Janja Snoj, Runkel, Agneta Annika, Castano, Argelia, Esteban-Lopez, Marta, Pedraza-Diaz, Susana, Akesson, Agneta, Lignell, Sanna, Vlaanderen, Jelle, Zock, Jan-Paul, Schoeters, Greet, and Kolossa-Gehring, Marike

Subjects
Human medicine
Abstract

Within the European Human Biomonitoring (HBM) Initiative HBM4EU we derived HBM indicators that were designed to help answering key policy questions and support chemical policies. The result indicators convey information on chemicals exposure of different age groups, sexes, geographical regions and time points by comparing median exposure values. If differences are observed for one group or the other, policy measures or risk management options can be implemented. Impact indicators support health risk assessment by comparing exposure values with health-based guidance values, such as human biomonitoring guidance values (HBM-GVs). In general, the indicators should be designed to translate complex scientific information into short and clear messages and make it accessible to policy makers but also to a broader audience such as stakeholders (e.g. NGO's), other scientists and the general public. Based on harmonized data from the HBM4EU Aligned Studies (2014-2021), the usefulness of our indicators was demonstrated for the age group children (6-11 years), using two case examples: one phthalate (Diisobutyl phthalate: DiBP) and one non-phthalate substitute (Di-isononyl cyclohexane-1,2- dicarboxylate: DINCH). For the comparison of age groups, these were compared to data for teenagers (12-18 years), and time periods were compared using data from the DEMOCOPHES project (2011-2012). Our result indicators proved to be suitable for demonstrating the effectiveness of policy measures for DiBP and the need of continuous monitoring for DINCH. They showed similar exposure for boys and girls, indicating that there is no need for gender focused interventions and/or no indication of sex-specific exposure patterns. They created a basis for a targeted approach by highlighting relevant geographical differences in internal exposure. An adequate data basis is essential for revealing differences for all indicators. This was particularly evident in our studies on the indicators on age differences. The impact indicator revealed that health risks based on exposure to DiBP cannot be excluded. This is an indication or flag for risk managers and policy makers that exposure to DiBP still is a relevant health issue. HBM indicators derived within HBM4EU are a valuable and important complement to existing indicator lists in the context of environment and health. Their applicability, current shortcomings and solution strategies are outlined.

Published
2023

27. Higher proportion of agricultural land use around the residence is associated with higher urinary concentrations of AMPA, a glyphosate metabolite

Author

De Troeyer, Katrien, primary, Casas, Lidia, additional, Bijnens, Esmée M, additional, Bruckers, Liesbeth, additional, Covaci, Adrian, additional, De Henauw, Stefaan, additional, Den Hond, Elly, additional, Loots, Ilse, additional, Nelen, Vera, additional, Verheyen, Veerle J, additional, Vos, Stijn, additional, Schoeters, Greet, additional, Hoppe, Hans-Wolfgang, additional, Köster, Helmut Dietrich, additional, and Nawrot, Tim S, additional

Published
2022
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32. Setting up a network of experts for developing a guidance document on how to deal with human biomonitoring in PFAS hotspots

Author

De Brouwere, Katleen, Colles, Ann, Knudsen, Lisbeth E., Den Hond, Elly, and Uhl, Maria

Subjects
PFAS, human biomonitoring, hotspots
Abstract

Exposure to per- and polyfluoroalkyl substances (PFAS), a widely-used class of persistentchemicals, has been linked to an array of adverse health outcomes. While most individuals inEurope are exposed to background-levels of PFAS, some populations living near contaminatedsites (‘PFAS hotspots’) are exposed at moderate, high or extremely high levels. Several PFAShotspots have been identified in various regions in the EU, and new PFAS hotspots continue to bediscovered. There is a large public health concern within several of these PFAS hotspots. In orderto address the health concern of citizens living in the neighbourhood of PFAS hotspots, humanbiomonitoring in hotspot regions have been conducted, or are ongoing or planned.Within the HBM4EU project, the need for a network of experts addressing PFAS exposure inhotspots in EU has been recognised. The collaboration within the network resulted in four main outcomes, reported in this document: An inventory of human biomonitoring studies in PFAS hotspots in Europe was created: overview the exposure levels, type and source of the contamination, exposuredeterminants, health research and policy impact of PFAS contamination at various hotspotsacross Europe A workshop on PFAS hotspots was organized (2 May 2022). During this half-day workshop, the knowledge and challenges related to PFAS hotspots across Europe werepresented and discussed with European, regional and local risk managers of contaminated sites, environmental health care workers, scientists, and regulatory authorities involved inchemical risk assessment. A guidance document on identification and monitoring, human biomonitoring, andrisk communication in PFAS hotspots has been drafted via collaboration within thenetwork. The guidance aims to be useful for policy makers and scientists confronted withnew PFAS hotpots (guidance document: see chapter 5 of this report).Recommendations for further research and policy recommendations. Recommendations for further research and policy recommendations &nbsp

Published
2022
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33. COVID-19 and children with congenital anomalies: a European survey of parents’ experiences of healthcare services

Author

Latos-Bieleńska, Anna, primary, Marcus, Elena, additional, Jamry-Dziurla, Anna, additional, Rankin, Judith, additional, Barisic, Ingeborg, additional, Cavero- Carbonell, Clara, additional, Den Hond, Elly, additional, Garne, Ester, additional, Genard, Lucas, additional, João Santos, Ana, additional, Lutke, L Renée, additional, Matias Dias, Carlos, additional, Neergaard Pedersen, Christina, additional, Neville, Amanda, additional, Niemann, Annika, additional, Odak, Ljubica, additional, Páramo-Rodríguez, Lucía, additional, Pierini, Anna, additional, Rissmann, Anke, additional, and Morris, Joan K, additional

Published
2022
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34. Temporal and geographical variations in survival of children born with congenital anomalies in Europe: A multi‐registry cohort study

Author

Santoro, Michele, primary, Coi, Alessio, additional, Pierini, Anna, additional, Rankin, Judith, additional, Glinianaia, Svetlana V., additional, Tan, Joachim, additional, Reid, Abigail, additional, Garne, Ester, additional, Loane, Maria, additional, Given, Joanne, additional, Aizpurua, Amaia, additional, Astolfi, Gianni, additional, Barisic, Ingeborg, additional, Cavero‐Carbonell, Clara, additional, de Walle, Hermien E. K., additional, Den Hond, Elly, additional, García‐Villodre, Laura, additional, Gatt, Miriam, additional, Gissler, Mika, additional, Jordan, Sue, additional, Khoshnood, Babak, additional, Kiuru‐Kuhlefelt, Sonja, additional, Klungsøyr, Kari, additional, Lelong, Nathalie, additional, Lutke, Renée, additional, Mokoroa, Olatz, additional, Nelen, Vera, additional, Neville, Amanda J., additional, Odak, Ljubica, additional, Rissmann, Anke, additional, Scanlon, Ieuan, additional, Urhoj, Stine Kjaer, additional, Wellesley, Diana, additional, Wertelecki, Wladimir, additional, Yevtushok, Lyubov, additional, and Morris, Joan K., additional

Published
2022
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35. Harmonization of Human Biomonitoring Studies in Europe: Characteristics of the HBM4EU-Aligned Studies Participants

Author

Gilles, Liese, primary, Govarts, Eva, additional, Rodriguez Martin, Laura, additional, Andersson, Anna-Maria, additional, Appenzeller, Brice M. R., additional, Barbone, Fabio, additional, Castaño, Argelia, additional, Coertjens, Dries, additional, Den Hond, Elly, additional, Dzhedzheia, Vazha, additional, Eržen, Ivan, additional, López, Marta Esteban, additional, Fábelová, Lucia, additional, Fillol, Clémence, additional, Franken, Carmen, additional, Frederiksen, Hanne, additional, Gabriel, Catherine, additional, Haug, Line Småstuen, additional, Horvat, Milena, additional, Halldórsson, Thórhallur Ingi, additional, Janasik, Beata, additional, Holcer, Nataša Janev, additional, Kakucs, Réka, additional, Karakitsios, Spyros, additional, Katsonouri, Andromachi, additional, Klánová, Jana, additional, Kold-Jensen, Tina, additional, Kolossa-Gehring, Marike, additional, Konstantinou, Corina, additional, Koponen, Jani, additional, Lignell, Sanna, additional, Lindroos, Anna Karin, additional, Makris, Konstantinos C., additional, Mazej, Darja, additional, Morrens, Bert, additional, Murínová, Ľubica Palkovičová, additional, Namorado, Sónia, additional, Pedraza-Diaz, Susana, additional, Peisker, Jasmin, additional, Probst-Hensch, Nicole, additional, Rambaud, Loïc, additional, Rosolen, Valentina, additional, Rucic, Enrico, additional, Rüther, Maria, additional, Sarigiannis, Dimosthenis, additional, Tratnik, Janja Snoj, additional, Standaert, Arnout, additional, Stewart, Lorraine, additional, Szigeti, Tamás, additional, Thomsen, Cathrine, additional, Tolonen, Hanna, additional, Eiríksdóttir, Ása, additional, Van Nieuwenhuyse, An, additional, Verheyen, Veerle J., additional, Vlaanderen, Jelle, additional, Vogel, Nina, additional, Wasowicz, Wojciech, additional, Weber, Till, additional, Zock, Jan-Paul, additional, Sepai, Ovnair, additional, and Schoeters, Greet, additional

Published
2022
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37. Temporal and geographical variations in survival of children born with congenital anomalies in Europe:A multi-registry cohort study

Author

Santoro, Michele, Coi, Alessio, Pierini, Anna, Rankin, Judith, Glinianaia, Svetlana V, Tan, Joachim, Reid, Abigail, Garne, Ester, Loane, Maria, Given, Joanne, Aizpurua, Amaia, Astolfi, Gianni, Barisic, Ingeborg, Cavero-Carbonell, Clara, de Walle, Hermien E K, Den Hond, Elly, García-Villodre, Laura, Gatt, Miriam, Gissler, Mika, Jordan, Sue, Khoshnood, Babak, Kiuru-Kuhlefelt, Sonja, Klungsøyr, Kari, Lelong, Nathalie, Lutke, Renée, Mokoroa, Olatz, Nelen, Vera, Neville, Amanda J, Odak, Ljubica, Rissmann, Anke, Scanlon, Ieuan, Urhoj, Stine Kjaer, Wellesley, Diana, Wertelecki, Wladimir, Yevtushok, Lyubov, Morris, Joan K, Santoro, Michele, Coi, Alessio, Pierini, Anna, Rankin, Judith, Glinianaia, Svetlana V, Tan, Joachim, Reid, Abigail, Garne, Ester, Loane, Maria, Given, Joanne, Aizpurua, Amaia, Astolfi, Gianni, Barisic, Ingeborg, Cavero-Carbonell, Clara, de Walle, Hermien E K, Den Hond, Elly, García-Villodre, Laura, Gatt, Miriam, Gissler, Mika, Jordan, Sue, Khoshnood, Babak, Kiuru-Kuhlefelt, Sonja, Klungsøyr, Kari, Lelong, Nathalie, Lutke, Renée, Mokoroa, Olatz, Nelen, Vera, Neville, Amanda J, Odak, Ljubica, Rissmann, Anke, Scanlon, Ieuan, Urhoj, Stine Kjaer, Wellesley, Diana, Wertelecki, Wladimir, Yevtushok, Lyubov, and Morris, Joan K

Abstract

BACKGROUND: Congenital anomalies are a major cause of perinatal, neonatal and infant mortality.OBJECTIVES: The aim was to investigate temporal changes and geographical variation in survival of children with major congenital anomalies (CA) in different European areas.METHODS: In this population-based linkage cohort study, 17 CA registries members of EUROCAT, the European network for the surveillance of CAs, successfully linked data on 115,219 live births with CAs to mortality records. Registries estimated Kaplan-Meier survival at 28 days and 5 years of age and fitted Cox's proportional hazards models comparing mortality at 1 year and 1-9 years of age for children born during 2005-2014 with those born during 1995-2004. The hazard ratios (HR) from each registry were combined centrally using a random-effects model. The 5-year survival conditional on having survived to 28 days of age was calculated.RESULTS: The overall risk of death by 1 year of age for children born with any major CA in 2005-2014 decreased compared to 1995-2004 (HR 0.68, 95% confidence interval [CI] 0.53, 0.89). Survival at 5 years of age ranged between registries from 97.6% to 87.0%. The lowest survival was observed for the registry of OMNI-Net (Ukraine) (87.0%, 95% CI 86.1, 87.9).CONCLUSIONS: Survival of children with CAs improved for births in 2005-2014 compared with 1995-2004. The use of CA registry data linked to mortality data enables investigation of survival of children with CAs. Factors such as defining major CAs, proportion of terminations of pregnancy for foetal anomaly, source of mortality data and linkage methods are important to consider in the design of future studies and in the interpretation of the results on survival of children with CAs.

Published
2022

39. Glyphosate and AMPA exposure in relation to markers of biological aging in an adult population-based study

Author

Cosemans, Charlotte, primary, Van Larebeke, Nicolas, additional, Janssen, Bram G, additional, Martens, Dries S, additional, Baeyens, Willy, additional, Bruckers, Liesbeth, additional, Den Hond, Elly, additional, Coertjens, Dries, additional, Nelen, Vera, additional, Schoeters, Greet, additional, Hoppe, Hans-Wolfgang, additional, Wolfs, Esther, additional, Smeets, Karen, additional, Nawrot, Tim S, additional, and Plusquin, Michelle, additional

Published
2022
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41. Per- en poly-fluoralkylstoffen in en rond de woning

Author

Colles, Ann, Bierkens, Johan, Jacobs, Griet, Govarts, Eva, Van Holderbeke, Mirja, Touchant, Kaat, Cops, Jirka, Willems, Hanny, Franken, Carmen, Den Hond, Elly, Groffen, Thimo, Lasters, Robin, and Bervoets, Lieven

Subjects
Biology
Abstract

Deze studie werd opgezet als een “proof of concept” of een pilootproject om een complexe studieopzet met metingen in meerdere compartimenten bij dezelfde deelnemers uit te testen en met als doel i) een zicht te krijgen op de PFAS-gehalten in deze compartimenten verspreid in Vlaanderen, ii) hypotheses te formuleren voor de bijdrage van deze compartimenten tot de PFAS-blootstelling en iii) hypotheses te formuleren voor mogelijke factoren die een invloed kunnen hebben op de waargenomen PFAS-gehalten.

Published
2022

42. Additional file 1 of Information needs of parents of children with congenital anomalies across Europe: a EUROlinkCAT survey

Author

Marcus, Elena, Latos-Bielenska, Anna, Jamry-Dziurla, Anna, Barišić, Ingeborg, Cavero-Carbonell, Clara, Den Hond, Elly, Garne, Ester, Genard, Lucas, Santos, Ana João, Lutke, LRenée, Matias Dias, Carlos, Neergaard Pedersen, Christina, Neville, Amanda J., Niemann, Annika, Odak, Ljubica, Pierini, Anna, Rico, Juan, Rissmann, Anke, Rankin, Judith, and Morris, Joan K.

Abstract

Additional file 1.

Published
2022
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43. Additional file 1 of Per- and polyfluoroalkyl substances (PFAS) and neurobehavioral function and cognition in adolescents (2010–2011) and elderly people (2014): results from the Flanders Environment and Health Studies (FLEHS)

Author

van Larebeke, Nicolas, Koppen, Gudrun, Decraemer, Sam, Colles, Ann, Bruckers, Liesbeth, Den Hond, Elly, Govarts, Eva, Morrens, Bert, Schettgen, Thomas, Remy, Sylvie, Coertjens, Dries, Nawrot, Tim, Nelen, Vera, Baeyens, Willy, and Schoeters, Greet

Abstract

Additional file 1 : Table S1. FLEHS-2 campaign on adolescents. List of confounders and potential covariates included in stepwise multiple or logistic regressions. Table S2. FLESH-3 campaign on adults. List of confounders and potential covariates included in stepwise multiple or logistic regressions. Table S3. Association of blood concentrations of perfluoro compounds with ln-transformed cognitive and neuropsychological parameters. Table S4. Association of blood concentrations of perfluoro compounds with non-transformed cognitive and neuropsychological parameters.

Published
2022
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48. Determinants of Chronic Biological Stress, Measured as Hair Cortisol Concentration, in a General Population of Adolescents: From Individual and Household Characteristics to Neighborhood Urbanicity

Author

Verheyen, Veerle J., primary, Remy, Sylvie, additional, Govarts, Eva, additional, Colles, Ann, additional, Koppen, Gudrun, additional, Martin, Laura Rodriguez, additional, Nielsen, Flemming, additional, Bruckers, Liesbeth, additional, Bijnens, Esmée M., additional, Vos, Stijn, additional, Morrens, Bert, additional, Coertjens, Dries, additional, Loots, Ilse, additional, De Decker, Annelies, additional, Franken, Carmen, additional, Den Hond, Elly, additional, Nelen, Vera, additional, De Henauw, Stefaan, additional, Covaci, Adrian, additional, Van Larebeke, Nicolas, additional, Teughels, Caroline, additional, Nawrot, Tim S., additional, and Schoeters, Greet, additional

Published
2021
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