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3. Supreme Court Abandons Distinction Between Primary-Coverage Clauses And Preventive-Warranty Clauses. Good Riddance?

Author

Den Hollander, Wouter

Subjects
Clauses (Law) -- Laws, regulations and rules, Insurance law -- Interpretation and construction, Government regulation, Business, international
Abstract

The Dutch Supreme Court handed down an important decision (ECLI:NL:HR:2024:258) on 16 February 2024 on the restrictive standard of reasonableness and fairness with respect to insurance policies. The Supreme Court [...]

Published
2024

4. Accuracy of upper endoscopies with random biopsies to identify patients with gastric premalignant lesions who can safely be exempt from surveillance

Author

Mommersteeg, Michiel C., Nieuwenburg, Stella A. V., den Hollander, Wouter J., Holster, Lisanne, den Hoed, Caroline M., Capelle, Lisette G., Tang, Tjon J., Anten, Marie- Paule, Prytz-Berset, Ingrid, Witteman, Ellen M., ter Borg, Frank, Burger, Jordy P. W., Doukas, Michail, Bruno, Marco J., Peppelenbosch, Maikel P., Fuhler, Gwenny M., Kuipers, Ernst J., and Spaander, Manon C. W.

Published
2021
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5. Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis.

Author

Castaño-Betancourt, Martha C, Evans, Dan S, Ramos, Yolande FM, Boer, Cindy G, Metrustry, Sarah, Liu, Youfang, den Hollander, Wouter, van Rooij, Jeroen, Kraus, Virginia B, Yau, Michelle S, Mitchell, Braxton D, Muir, Kenneth, Hofman, Albert, Doherty, Michael, Doherty, Sally, Zhang, Weiya, Kraaij, Robert, Rivadeneira, Fernando, Barrett-Connor, Elizabeth, Maciewicz, Rose A, Arden, Nigel, Nelissen, Rob GHH, Kloppenburg, Margreet, Jordan, Joanne M, Nevitt, Michael C, Slagboom, Eline P, Hart, Deborah J, Lafeber, Floris, Styrkarsdottir, Unnur, Zeggini, Eleftheria, Evangelou, Evangelos, Spector, Tim D, Uitterlinden, Andre G, Lane, Nancy E, Meulenbelt, Ingrid, Valdes, Ana M, and van Meurs, Joyce BJ

Subjects
Cartilage, Hip Joint, Humans, Osteoarthritis, Hip, Genetic Predisposition to Disease, Trehalase, Transforming Growth Factor alpha, Regulatory Sequences, Nucleic Acid, Genetic Heterogeneity, Polymorphism, Single Nucleotide, Aged, Aged, 80 and over, Middle Aged, Female, Male, Receptor, Fibroblast Growth Factor, Type 3, Genome-Wide Association Study, Phosphatidylinositol 3-Kinases, Class Ia Phosphatidylinositol 3-Kinase, Osteoarthritis, Hip, Regulatory Sequences, Nucleic Acid, Polymorphism, Single Nucleotide, and over, Receptor, Fibroblast Growth Factor, Type 3, Genetics, Developmental Biology
Abstract

Osteoarthritis is one of the most frequent and disabling diseases of the elderly. Only few genetic variants have been identified for osteoarthritis, which is partly due to large phenotype heterogeneity. To reduce heterogeneity, we here examined cartilage thickness, one of the structural components of joint health. We conducted a genome-wide association study of minimal joint space width (mJSW), a proxy for cartilage thickness, in a discovery set of 13,013 participants from five different cohorts and replication in 8,227 individuals from seven independent cohorts. We identified five genome-wide significant (GWS, P≤5·0×10-8) SNPs annotated to four distinct loci. In addition, we found two additional loci that were significantly replicated, but results of combined meta-analysis fell just below the genome wide significance threshold. The four novel associated genetic loci were located in/near TGFA (rs2862851), PIK3R1 (rs10471753), SLBP/FGFR3 (rs2236995), and TREH/DDX6 (rs496547), while the other two (DOT1L and SUPT3H/RUNX2) were previously identified. A systematic prioritization for underlying causal genes was performed using diverse lines of evidence. Exome sequencing data (n = 2,050 individuals) indicated that there were no rare exonic variants that could explain the identified associations. In addition, TGFA, FGFR3 and PIK3R1 were differentially expressed in OA cartilage lesions versus non-lesioned cartilage in the same individuals. In conclusion, we identified four novel loci (TGFA, PIK3R1, FGFR3 and TREH) and confirmed two loci known to be associated with cartilage thickness.The identified associations were not caused by rare exonic variants. This is the first report linking TGFA to human OA, which may serve as a new target for future therapies.

Published
2016

6. The transcriptional landscape of age in human peripheral blood.

Author

Peters, Marjolein J, Joehanes, Roby, Pilling, Luke C, Schurmann, Claudia, Conneely, Karen N, Powell, Joseph, Reinmaa, Eva, Sutphin, George L, Zhernakova, Alexandra, Schramm, Katharina, Wilson, Yana A, Kobes, Sayuko, Tukiainen, Taru, NABEC/UKBEC Consortium, Ramos, Yolande F, Göring, Harald HH, Fornage, Myriam, Liu, Yongmei, Gharib, Sina A, Stranger, Barbara E, De Jager, Philip L, Aviv, Abraham, Levy, Daniel, Murabito, Joanne M, Munson, Peter J, Huan, Tianxiao, Hofman, Albert, Uitterlinden, André G, Rivadeneira, Fernando, van Rooij, Jeroen, Stolk, Lisette, Broer, Linda, Verbiest, Michael MPJ, Jhamai, Mila, Arp, Pascal, Metspalu, Andres, Tserel, Liina, Milani, Lili, Samani, Nilesh J, Peterson, Pärt, Kasela, Silva, Codd, Veryan, Peters, Annette, Ward-Caviness, Cavin K, Herder, Christian, Waldenberger, Melanie, Roden, Michael, Singmann, Paula, Zeilinger, Sonja, Illig, Thomas, Homuth, Georg, Grabe, Hans-Jörgen, Völzke, Henry, Steil, Leif, Kocher, Thomas, Murray, Anna, Melzer, David, Yaghootkar, Hanieh, Bandinelli, Stefania, Moses, Eric K, Kent, Jack W, Curran, Joanne E, Johnson, Matthew P, Williams-Blangero, Sarah, Westra, Harm-Jan, McRae, Allan F, Smith, Jennifer A, Kardia, Sharon LR, Hovatta, Iiris, Perola, Markus, Ripatti, Samuli, Salomaa, Veikko, Henders, Anjali K, Martin, Nicholas G, Smith, Alicia K, Mehta, Divya, Binder, Elisabeth B, Nylocks, K Maria, Kennedy, Elizabeth M, Klengel, Torsten, Ding, Jingzhong, Suchy-Dicey, Astrid M, Enquobahrie, Daniel A, Brody, Jennifer, Rotter, Jerome I, Chen, Yii-Der I, Houwing-Duistermaat, Jeanine, Kloppenburg, Margreet, Slagboom, P Eline, Helmer, Quinta, den Hollander, Wouter, Bean, Shannon, Raj, Towfique, Bakhshi, Noman, Wang, Qiao Ping, Oyston, Lisa J, Psaty, Bruce M, Tracy, Russell P, Montgomery, Grant W, and Turner, Stephen T

Subjects
NABEC/UKBEC Consortium, Humans, Gene Expression Profiling, DNA Methylation, Aging, European Continental Ancestry Group, Transcriptome, Biomarkers
Abstract

Disease incidences increase with age, but the molecular characteristics of ageing that lead to increased disease susceptibility remain inadequately understood. Here we perform a whole-blood gene expression meta-analysis in 14,983 individuals of European ancestry (including replication) and identify 1,497 genes that are differentially expressed with chronological age. The age-associated genes do not harbor more age-associated CpG-methylation sites than other genes, but are instead enriched for the presence of potentially functional CpG-methylation sites in enhancer and insulator regions that associate with both chronological age and gene expression levels. We further used the gene expression profiles to calculate the 'transcriptomic age' of an individual, and show that differences between transcriptomic age and chronological age are associated with biological features linked to ageing, such as blood pressure, cholesterol levels, fasting glucose, and body mass index. The transcriptomic prediction model adds biological relevance and complements existing epigenetic prediction models, and can be used by others to calculate transcriptomic age in external cohorts.

Published
2015

7. Secondhand smoke exposure in public outdoor spaces in the Netherlands: The stronger the smell, the more exposure to nicotine.

Author

Bommelé, Jeroen, Cremers, Hans, Den Hollander, Wouter, Troelstra, Sigrid, Geuke, Gemma, Dam, Wiebe, Willemse, Eefje, Hopman, Petra, Walters, Bethany Hipple, and Willemsen, Marc

Subjects
SMOKING prevention, RESEARCH funding, NICOTINE, HEALTH policy, DESCRIPTIVE statistics, PUBLIC spaces, SMELL, GAS chromatography, ENVIRONMENTAL exposure, MASS spectrometry, TOBACCO products, CONFIDENCE intervals, PASSIVE smoking
Abstract

INTRODUCTION While secondhand smoke exposure in outdoor spaces has been investigated before, no data on outdoor secondhand smoke exposure have been collected in the Netherlands. Such data could help policymakers gain support for smoke-free outdoor public spaces. METHODS Between May and November 2021, we visited 25 outdoor locations across the Netherlands. At each location, we conducted four measurements with smokers and one measurement without smokers. During each measurement, we counted the number of smokers present and we rated tobacco smell intensity on a five-point scale. Airborne nicotine and 3-ethenylpyridine (3-EP) data were collected through active sampling on thermal desorption tubes. The contents of these tubes were later analyzed using gas chromatography-mass spectrometry. Using linear mixed models, we investigated the association between levels of nicotine and the presence of smokers, the number of smokers, and the intensity of tobacco smell. We also investigated these association with levels of 3-EP. RESULTS Nicotine levels were higher when smokers were present (B=1.40; 95% CI: 0.69-2.11, p<0.001). For each additional smoker present, we measured higher levels of nicotine (B=0.23; 95% CI: 0.10-0.37, p=0.001). When the smell of tobacco smoke was noted to be stronger by the researchers, higher levels of nicotine were measured through sampling (B=0.85; 95% CI: 0.44-1.26, p<0.001). We found similar results for 3-EP levels. CONCLUSIONS This study showed that both nicotine and 3-EP are useful in quantifying levels of secondhand smoke in various outdoor locations. The level of nicotine exposure outdoors was positively associated with the number of smokers nearby. The intensity of the tobacco smell was also related to nicotine exposure: the stronger the smell of tobacco smoke, the more nicotine was measured in the air. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury

Author

Copple, Ian M., den Hollander, Wouter, Callegaro, Giulia, Mutter, Fiona E., Maggs, James L., Schofield, Amy L., Rainbow, Lucille, Fang, Yongxiang, Sutherland, Jeffrey J., Ellis, Ewa C., Ingelman-Sundberg, Magnus, Fenwick, Stephen W., Goldring, Christopher E., van de Water, Bob, Stevens, James L., and Park, B. Kevin

Published
2019
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14. Genome-wide association and functional studies identify a role for matrix Gla protein in osteoarthritis of the hand

Author

den Hollander, Wouter, Boer, Cindy G, Hart, Deborah J, Yau, Michelle S, Ramos, Yolande F M, Metrustry, Sarah, Broer, Linda, Deelen, Joris, Cupples, L Adrienne, Rivadeneira, Fernando, Kloppenburg, Margreet, Peters, Marjolein, Spector, Tim D, Hofman, Albert, Slagboom, P Eline, Nelissen, Rob G H H, Uitterlinden, André G, Felson, David T, Valdes, Ana M, Meulenbelt, Ingrid, and van Meurs, Joyce J B

Published
2017
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15. Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation

Author

Teumer, Alexander, Chaker, Layal, Groeneweg, Stefan, Li, Yong, Di Munno, Celia, Barbieri, Caterina, Schultheiss, Ulla T., Traglia, Michela, Ahluwalia, Tarunveer S., Akiyama, Masato, Appel, Emil Vincent R., Arking, Dan E., Arnold, Alice, Astrup, Arne, Beekman, Marian, Beilby, John P., Bekaert, Sofie, Boerwinkle, Eric, Brown, Suzanne J., De Buyzere, Marc, Campbell, Purdey J., Ceresini, Graziano, Cerqueira, Charlotte, Cucca, Francesco, Deary, Ian J., Deelen, Joris, Eckardt, Kai-Uwe, Ekici, Arif B., Eriksson, Johan G., Ferrrucci, Luigi, Fiers, Tom, Fiorillo, Edoardo, Ford, Ian, Fox, Caroline S., Fuchsberger, Christian, Galesloot, Tessel E., Gieger, Christian, Gögele, Martin, De Grandi, Alessandro, Grarup, Niels, Greiser, Karin Halina, Haljas, Kadri, Hansen, Torben, Harris, Sarah E., van Heemst, Diana, den Heijer, Martin, Hicks, Andrew A., den Hollander, Wouter, Homuth, Georg, Hui, Jennie, Ikram, M. Arfan, Ittermann, Till, Jensen, Richard A., Jing, Jiaojiao, Jukema, J. Wouter, Kajantie, Eero, Kamatani, Yoichiro, Kasbohm, Elisa, Kaufman, Jean-Marc, Kiemeney, Lambertus A., Kloppenburg, Margreet, Kronenberg, Florian, Kubo, Michiaki, Lahti, Jari, Lapauw, Bruno, Li, Shuo, Liewald, David C. M., Lifelines Cohort Study, Lim, Ee Mun, Linneberg, Allan, Marina, Michela, Mascalzoni, Deborah, Matsuda, Koichi, Medenwald, Daniel, Meisinger, Christa, Meulenbelt, Ingrid, De Meyer, Tim, Meyer zu Schwabedissen, Henriette E., Mikolajczyk, Rafael, Moed, Matthijs, Netea-Maier, Romana T., Nolte, Ilja M., Okada, Yukinori, Pala, Mauro, Pattaro, Cristian, Pedersen, Oluf, Petersmann, Astrid, Porcu, Eleonora, Postmus, Iris, Pramstaller, Peter P., Psaty, Bruce M., Ramos, Yolande F. M., Rawal, Rajesh, Redmond, Paul, Richards, J. Brent, Rietzschel, Ernst R., Rivadeneira, Fernando, Roef, Greet, Rotter, Jerome I., Sala, Cinzia F., Schlessinger, David, Selvin, Elizabeth, Slagboom, P. Eline, Soranzo, Nicole, Sørensen, Thorkild I. A., Spector, Timothy D., Starr, John M., Stott, David J., Taes, Youri, Taliun, Daniel, Tanaka, Toshiko, Thuesen, Betina, Tiller, Daniel, Toniolo, Daniela, Uitterlinden, Andre G., Visser, W. Edward, Walsh, John P., Wilson, Scott G., Wolffenbuttel, Bruce H. R., Yang, Qiong, Zheng, Hou-Feng, Cappola, Anne, Peeters, Robin P., Naitza, Silvia, Völzke, Henry, Sanna, Serena, Köttgen, Anna, Visser, Theo J., and Medici, Marco

Published
2018
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17. Smart continence care for people with profound intellectual and multiple disabilities: Protocol for a cluster randomized trial and trial-based economic evaluation

Author

Van Cooten, Vivette J C, Gielissen, Marieke F M, Van Mastrigt, Ghislaine A P G, Den Hollander, Wouter, Evers, Silvia M A A, Smeets, Odile, Smit, Filip, Boon, Brigitte, Van Cooten, Vivette J C, Gielissen, Marieke F M, Van Mastrigt, Ghislaine A P G, Den Hollander, Wouter, Evers, Silvia M A A, Smeets, Odile, Smit, Filip, and Boon, Brigitte

Abstract

Background: People with profound intellectual and multiple disabilities (PIMD) cannot communicate the need to change their incontinence products. The smart continence care (SCC) product Abena Nova signals caregivers when change is needed. This provides the opportunity for more person-centered care, increased quality of life, and a decreased number of leakages. However, there is a need for evidence of the effectiveness and cost-effectiveness of such technology compared with regular continence care (RCC) for people with PIMD. Objective: This paper presents the research protocol for an effectiveness and cost-effectiveness study with people with PIMD living in long-term care facilities in the Netherlands. Methods: A cluster randomized trial will be conducted in 3 consecutive waves across 6 long-term care providers for people with disabilities and 160 participants with PIMD. Long-term care providers are randomized at a 1:1 ratio, resulting in an intervention group and a group continuing RCC. The intervention group will receive implementation guidance and use SCC for 3 months; the other group will continue their RCC as usual and then switch to SCC. This study consists of three components: effectiveness study, economic evaluation, and process evaluation. The primary outcome will be a change in the number of leakages. The secondary outcomes are quality of life, the difference in the number of changes, the work perception of caregivers, cost-effectiveness, and cost utility. Data collection will occur at T0 (baseline), T1 (6 weeks), T2 (12 weeks), and T3 (9-month follow-up) for the first 2 intervention groups. An intention-to-treat analysis will be performed. The economic evaluation will be conducted alongside the trial from the societal and long-term care provider perspectives. Qualitative data collection through interviews and field notes will complement these quantitative results and provide input for the process evaluation. Results

Published
2022

21. The human hepatocyte TXG-MAPr: gene co-expression network modules to support mechanism-based risk assessment

Author

Callegaro, Giulia, primary, Kunnen, Steven J., additional, Trairatphisan, Panuwat, additional, Grosdidier, Solène, additional, Niemeijer, Marije, additional, den Hollander, Wouter, additional, Guney, Emre, additional, Piñero Gonzalez, Janet, additional, Furlong, Laura, additional, Webster, Yue W., additional, Saez-Rodriguez, Julio, additional, Sutherland, Jeffrey J., additional, Mollon, Jennifer, additional, Stevens, James L., additional, and van de Water, Bob, additional

Published
2021
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24. Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis

Author

Bomer, Nils, den Hollander, Wouter, Ramos, Yolande F M, Bos, Steffan D, van der Breggen, Ruud, Lakenberg, Nico, Pepers, Barry A, van Eeden, Annelies E, Darvishan, Arash, Tobi, Elmar W, Duijnisveld, Bouke J, van den Akker, Erik B, Heijmans, Bastiaan T, van Roon-Mom, Willeke MC, Verbeek, Fons J, van Osch, Gerjo J V M, Nelissen, Rob G H H, Slagboom, P Eline, and Meulenbelt, Ingrid

Published
2015
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26. Pragmatic Quasi-Experimental Controlled Trial Evaluating the Outcomes of Blended CBT Compared to Face-to-Face CBT and Treatment as Usual for Adolescents with Depressive Disorders

Author

Rasing, Sanne P.a., Stikkelbroek, Yvonne A.j., Den Hollander, Wouter, Riper, Heleen, Deković, Maja, Nauta, Maaike H., Creemers, Daan H.m., Immink, Marianne C.p., Spuij, Mariken, Bodden, Denise H.m., Leerstoel Dekovic, Leerstoel Baar, Development and Treatment of Psychosocial Problems, Clinical Psychology, APH - Global Health, APH - Mental Health, Psychiatry, Leerstoel Dekovic, Leerstoel Baar, Development and Treatment of Psychosocial Problems, and Clinical Psychology and Experimental Psychopathology

Subjects
Adult, Male, Adolescent, Cost-Benefit Analysis, medicine.medical_treatment, Health, Toxicology and Mutagenesis, lcsh:Medicine, Treatment as usual, CBT, Adolescents, Article, Blended treatment, law.invention, Young Adult, 03 medical and health sciences, Face-to-face, 0302 clinical medicine, Randomized controlled trial, SDG 3 - Good Health and Well-being, law, Humans, Medicine, Toxicology and Mutagenesis, 030212 general & internal medicine, Suicide Risk, Blended, Depression (differential diagnoses), Depressive Disorder, Major, Cognitive Behavioral Therapy, business.industry, Depression, Environmental and Occupational Health, lcsh:R, Public Health, Environmental and Occupational Health, Mental health, Pollution, 030227 psychiatry, Cognitive behavioral therapy, Treatment, Mental Health, Treatment Outcome, Health, Female, Public Health, business, Developmental Psychopathology, Clinical psychology
Abstract

Contains fulltext : 234365.pdf (Publisher’s version ) (Open Access) Depression is a major problem in youth mental health. Current treatment is on average effective, but adolescents are hesitant to seek help. Blended treatment could lower the barriers to seeking treatment. Evidence on effectiveness is, however, scarce. The present pragmatic quasi-experimental controlled trial aimed to compare the outcomes of blended cognitive behavioral therapy (CBT) to face-to-face CBT and treatment as usual. A total of 129 adolescents with clinical depression (82.2% female), aged 13-22 (M = 16.60, SD = 2.03) received blended CBT, face-to-face CBT or treatment as usual. Clinical diagnosis, depressive symptoms, and secondary outcomes were assessed at baseline, post-intervention, and six-months follow-up. Participants receiving blended CBT were, compared to participants receiving face-to-face CBT and treatment as usual, evenly likely to be in remission from their depressive disorder at post-intervention and at six-month follow-up. Depressive symptoms decreased significantly over time in all three conditions, and changes were not significantly different between conditions. Other secondary outcomes (suicide risk, internalizing and externalizing symptoms, severity of depression, and global functioning) did not differ between treatment conditions at post-intervention and six-month follow-up. Since there was no evidence for favorable outcomes for face-to-face therapies above blended CBT, blended CBT may also be an effective treatment format in clinical practice. 17 p.

Published
2021

28. Long Term Outcomes of Blended CBT Compared to Face-to-Face CBT and Treatment as Usual for Adolescents with Depressive Disorders: Analyses at 12 Months Post-Treatment

Author

Leerstoel Dekovic, Leerstoel Baar, Development and Treatment of Psychosocial Problems, Rasing, Sanne P. A., Stikkelbroek, Yvonne A. J., Den Hollander, Wouter, Okorn, Ana, Bodden, Denise H. M., Leerstoel Dekovic, Leerstoel Baar, Development and Treatment of Psychosocial Problems, Rasing, Sanne P. A., Stikkelbroek, Yvonne A. J., Den Hollander, Wouter, Okorn, Ana, and Bodden, Denise H. M.

Published
2021

29. Pragmatic Quasi-Experimental Controlled Trial Evaluating the Outcomes of Blended CBT Compared to Face-to-Face CBT and Treatment as Usual for Adolescents with Depressive Disorders

Author

Leerstoel Dekovic, Leerstoel Baar, Development and Treatment of Psychosocial Problems, Rasing, Sanne P.a., Stikkelbroek, Yvonne A.j., Den Hollander, Wouter, Riper, Heleen, Deković, Maja, Nauta, Maaike H., Creemers, Daan H.m., Immink, Marianne C.p., Spuij, Mariken, Bodden, Denise H.m., Leerstoel Dekovic, Leerstoel Baar, Development and Treatment of Psychosocial Problems, Rasing, Sanne P.a., Stikkelbroek, Yvonne A.j., Den Hollander, Wouter, Riper, Heleen, Deković, Maja, Nauta, Maaike H., Creemers, Daan H.m., Immink, Marianne C.p., Spuij, Mariken, and Bodden, Denise H.m.

Published
2021

30. Identification and characterization of two consistent osteoarthritis subtypes by transcriptome and clinical data integration

Author

Coutinho de Almeida, Rodrigo (author), Mahfouz, A.M.E.T.A. (author), Mei, Hailiang (author), Houtman, Evelyn (author), den Hollander, Wouter (author), Soul, Jamie (author), Suchiman, Eka (author), Nelissen, R.G.H.H. (author), Reinders, M.J.T. (author), Coutinho de Almeida, Rodrigo (author), Mahfouz, A.M.E.T.A. (author), Mei, Hailiang (author), Houtman, Evelyn (author), den Hollander, Wouter (author), Soul, Jamie (author), Suchiman, Eka (author), Nelissen, R.G.H.H. (author), and Reinders, M.J.T. (author)

Abstract

OBJECTIVE: To identify OA subtypes based on cartilage transcriptomic data in cartilage tissue and characterize their underlying pathophysiological processes and/or clinically relevant characteristics. METHODS: This study includes n = 66 primary OA patients (41 knees and 25 hips), who underwent a joint replacement surgery, from which macroscopically unaffected (preserved, n = 56) and lesioned (n = 45) OA articular cartilage were collected [Research Arthritis and Articular Cartilage (RAAK) study]. Unsupervised hierarchical clustering analysis on preserved cartilage transcriptome followed by clinical data integration was performed. Protein-protein interaction (PPI) followed by pathway enrichment analysis were done for genes significant differentially expressed between subgroups with interactions in the PPI network. RESULTS: Analysis of preserved samples (n = 56) resulted in two OA subtypes with n = 41 (cluster A) and n = 15 (cluster B) patients. The transcriptomic profile of cluster B cartilage, relative to cluster A (DE-AB genes) showed among others a pronounced upregulation of multiple genes involved in chemokine pathways. Nevertheless, upon investigating the OA pathophysiology in cluster B patients as reflected by differentially expressed genes between preserved and lesioned OA cartilage (DE-OA-B genes), the chemokine genes were significantly downregulated with OA pathophysiology. Upon integrating radiographic OA data, we showed that the OA phenotype among cluster B patients, relative to cluster A, may be characterized by higher joint space narrowing (JSN) scores and low osteophyte (OP) scores. CONCLUSION: Based on whole-transcriptome profiling, we identified two robust OA subtypes characterized by unique OA, pathophysiological processes in cartilage as well as a clinical phenotype. We advocate that further characterization, confirmation and clinical data integration is a prerequisite to allow for development of treatments towards personalized care with concurren, Pattern Recognition and Bioinformatics

Published
2021
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31. Effectiveness of resource groups for improving empowerment, quality of life, and functioning of people with severe mental illness: A randomized clinical trial

Author

Tjaden, Cathelijn, Mulder, Cornelis L., Den Hollander, Wouter, Castelein, Stynke, Delespaul, Philippe, Keet, Rene, Van Weeghel, Jaap, Kroon, Hans, Tjaden, Cathelijn, Mulder, Cornelis L., Den Hollander, Wouter, Castelein, Stynke, Delespaul, Philippe, Keet, Rene, Van Weeghel, Jaap, and Kroon, Hans

Abstract

Importance: Although the importance of recovery-oriented care for people with severe mental illness (SMI) is widely acknowledged, essential elements such as personalization and involvement of significant others are not adequately implemented in practice. Objective: To determine whether using resource groups (RGs) within flexible assertive community treatment (FACT) has favorable effects on empowerment and recovery-related outcomes in people with SMI. Design, Setting, and Participants: This assessor-blind, multisite randomized clinical trial was conducted from September 1, 2017, to September 30, 2020, with follow-up at 9 and 18 months. A total of 158 participants aged 18 to 65 years meeting the criteria for SMI were randomly allocated to FACT plus RG vs FACT as usual (1:1) in 20 FACT teams throughout the Netherlands. Data were analyzed from September 1, 2020, to January 31, 2021. The study was prespecified in the trial protocol and data from the intent-to-treat population were analyzed. Interventions: In the FACT plus RG condition, patients chose members from their informal and formal networks to form an RG that meets quarterly to discuss self-formulated recovery goals. The RG was integrated into the multidisciplinary support provided by the FACT team. In the FACT as-usual condition, empowerment (defined as overcoming powerlessness and gaining control of one’s life) and involvement of significant others was also part of the provided care, but without the structure of the RG. Main Outcomes and Measures: The primary outcome was self-reported empowerment, measured with the Netherlands Empowerment List. Results: A total of 158 participants with SMI (median age, 38 [median absolute deviation, 13] years; 93 men [58.9%]) were randomized to FACT plus RG (n = 80) or FACT as usual (n = 78) care. Intention-to-treat analyses showed that randomization to the RG condition was associated with a clinically signifi

Published
2021

32. Effectiveness of Resource Groups for Improving Empowerment, Quality of Life, and Functioning of People with Severe Mental Illness:A Randomized Clinical Trial

Author

Tjaden, Cathelijn, Mulder, Cornelis L., Den Hollander, Wouter, Castelein, Stynke, Delespaul, Philippe, Keet, Rene, Van Weeghel, Jaap, Kroon, Hans, Tjaden, Cathelijn, Mulder, Cornelis L., Den Hollander, Wouter, Castelein, Stynke, Delespaul, Philippe, Keet, Rene, Van Weeghel, Jaap, and Kroon, Hans

Abstract

Importance: Although the importance of recovery-oriented care for people with severe mental illness (SMI) is widely acknowledged, essential elements such as personalization and involvement of significant others are not adequately implemented in practice. Objective: To determine whether using resource groups (RGs) within flexible assertive community treatment (FACT) has favorable effects on empowerment and recovery-related outcomes in people with SMI. Design, Setting, and Participants: This assessor-blind, multisite randomized clinical trial was conducted from September 1, 2017, to September 30, 2020, with follow-up at 9 and 18 months. A total of 158 participants aged 18 to 65 years meeting the criteria for SMI were randomly allocated to FACT plus RG vs FACT as usual (1:1) in 20 FACT teams throughout the Netherlands. Data were analyzed from September 1, 2020, to January 31, 2021. The study was prespecified in the trial protocol and data from the intent-to-treat population were analyzed. Interventions: In the FACT plus RG condition, patients chose members from their informal and formal networks to form an RG that meets quarterly to discuss self-formulated recovery goals. The RG was integrated into the multidisciplinary support provided by the FACT team. In the FACT as-usual condition, empowerment (defined as overcoming powerlessness and gaining control of one's life) and involvement of significant others was also part of the provided care, but without the structure of the RG. Main Outcomes and Measures: The primary outcome was self-reported empowerment, measured with the Netherlands Empowerment List. Results: A total of 158 participants with SMI (median age, 38 [median absolute deviation, 13] years; 93 men [58.9%]) were randomized to FACT plus RG (n = 80) or FACT as usual (n = 78) care. Intention-to-treat analyses showed that randomization to the RG condition was associated with a clinically significant increase in empowerment (Cohen d, 0.54; 95% CI, 0.21-0.86) and

Published
2021

33. The human hepatocyte TXG-MAPr:gene co-expression network modules to support mechanism-based risk assessment

Author

Callegaro, Giulia, Kunnen, Steven J., Trairatphisan, Panuwat, Grosdidier, Solène, Niemeijer, Marije, den Hollander, Wouter, Guney, Emre, Piñero Gonzalez, Janet, Furlong, Laura, Webster, Yue W., Saez-Rodriguez, Julio, Sutherland, Jeffrey J., Mollon, Jennifer, Stevens, James L., van de Water, Bob, Callegaro, Giulia, Kunnen, Steven J., Trairatphisan, Panuwat, Grosdidier, Solène, Niemeijer, Marije, den Hollander, Wouter, Guney, Emre, Piñero Gonzalez, Janet, Furlong, Laura, Webster, Yue W., Saez-Rodriguez, Julio, Sutherland, Jeffrey J., Mollon, Jennifer, Stevens, James L., and van de Water, Bob

Abstract

Mechanism-based risk assessment is urged to advance and fully permeate into current safety assessment practices, possibly at early phases of drug safety testing. Toxicogenomics is a promising source of mechanisms-revealing data, but interpretative analysis tools specific for the testing systems (e.g. hepatocytes) are lacking. In this study, we present the TXG-MAPr webtool (available at https://txg-mapr.eu/WGCNA_PHH/TGGATEs_PHH/), an R-Shiny-based implementation of weighted gene co-expression network analysis (WGCNA) obtained from the Primary Human Hepatocytes (PHH) TG-GATEs dataset. The 398 gene co-expression networks (modules) were annotated with functional information (pathway enrichment, transcription factor) to reveal their mechanistic interpretation. Several well-known stress response pathways were captured in the modules, were perturbed by specific stressors and showed preservation in rat systems (rat primary hepatocytes and rat in vivo liver), with the exception of DNA damage and oxidative stress responses. A subset of 87 well-annotated and preserved modules was used to evaluate mechanisms of toxicity of endoplasmic reticulum (ER) stress and oxidative stress inducers, including cyclosporine A, tunicamycin and acetaminophen. In addition, module responses can be calculated from external datasets obtained with different hepatocyte cells and platforms, including targeted RNA-seq data, therefore, imputing biological responses from a limited gene set. As another application, donors’ sensitivity towards tunicamycin was investigated with the TXG-MAPr, identifying higher basal level of intrinsic immune response in donors with pre-existing liver pathology. In conclusion, we demonstrated that gene co-expression analysis coupled to an interactive visualization environment, the TXG-MAPr, is a promising approach to achieve mechanistic relevant, cross-species and cross-platform evaluation of toxicogenomic data.

Published
2021

35. The human hepatocyte TXG-MAPr: WGCNA transcriptomic modules to support mechanism-based risk assessment

Author

Callegaro, Giulia, primary, Kunnen, Steven J., additional, Trairatphisan, Panuwat, additional, Grosdidier, Solene, additional, Niemeijer, Marije, additional, den Hollander, Wouter, additional, Guney, Emre, additional, Gonzalez, Janet Pinero, additional, Furlong, Laura, additional, Webster, Yue W., additional, Saez-Rodriguez, Julio, additional, Sutherland, Jeffrey J., additional, Mollon, Jennifer, additional, Stevens, James L., additional, and van de Water, Bob, additional

Published
2021
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38. Identification and characterization of two consistent osteoarthritis subtypes by transcriptome and clinical data integration

Author

Coutinho de Almeida, Rodrigo, primary, Mahfouz, Ahmed, additional, Mei, Hailiang, additional, Houtman, Evelyn, additional, den Hollander, Wouter, additional, Soul, Jamie, additional, Suchiman, Eka, additional, Lakenberg, Nico, additional, Meessen, Jennifer, additional, Huetink, Kasper, additional, Nelissen, Rob G H H, additional, Ramos, Yolande F M, additional, Reinders, Marcel, additional, and Meulenbelt, Ingrid, additional

Published
2020
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39. Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

Author

Ligthart, Symen, Vaez, Ahmad, Võsa, Urmo, Stathopoulou, Maria G, de Vries, Paul S, Prins, Bram P, Van der Most, Peter J, Tanaka, Toshiko, Naderi, Elnaz, Rose, Lynda M, Wu, Ying, Karlsson, Robert, Barbalic, Maja, Lin, Honghuang, Pool, René, Zhu, Gu, Macé, Aurélien, Sidore, Carlo, Trompet, Stella, Mangino, Massimo, Sabater-Lleal, Maria, Kemp, John P, Abbasi, Ali, Kacprowski, Tim, Verweij, Niek, Smith, Albert V, Huang, Tao, Marzi, Carola, Feitosa, Mary F, Lohman, Kurt K, Kleber, Marcus E, Milaneschi, Yuri, Mueller, Christian, Huq, Mahmudul, Vlachopoulou, Efthymia, Lyytikäinen, Leo-Pekka, Oldmeadow, Christopher, Deelen, Joris, Perola, Markus, Zhao, Jing Hua, Feenstra, Bjarke, LifeLines Cohort Study, Amini, Marzyeh, CHARGE Inflammation Working Group, Lahti, Jari, Schraut, Katharina E, Fornage, Myriam, Suktitipat, Bhoom, Chen, Wei-Min, Li, Xiaohui, Nutile, Teresa, Malerba, Giovanni, Luan, Jian'an, Bak, Tom, Schork, Nicholas, Del Greco M, Fabiola, Thiering, Elisabeth, Mahajan, Anubha, Marioni, Riccardo E, Mihailov, Evelin, Eriksson, Joel, Ozel, Ayse Bilge, Zhang, Weihua, Nethander, Maria, Cheng, Yu-Ching, Aslibekyan, Stella, Ang, Wei, Gandin, Ilaria, Yengo, Loïc, Portas, Laura, Kooperberg, Charles, Hofer, Edith, Rajan, Kumar B, Schurmann, Claudia, den Hollander, Wouter, Ahluwalia, Tarunveer S, Zhao, Jing, Draisma, Harmen HM, Ford, Ian, Timpson, Nicholas, Teumer, Alexander, Huang, Hongyan, Wahl, Simone, Liu, YongMei, Huang, Jie, Uh, Hae-Won, Geller, Frank, Joshi, Peter K, Yanek, Lisa R, Trabetti, Elisabetta, Lehne, Benjamin, Vozzi, Diego, Verbanck, Marie, Biino, Ginevra, Saba, Yasaman, Meulenbelt, Ingrid, O'Connell, Jeff R, Laakso, Markku, Giulianini, Franco, and Magnusson, Patrik KE

Subjects
Adult, Male, Bipolar Disorder, Adolescent, CHARGE Inflammation Working Group, Medical and Health Sciences, Body Mass Index, C-reactive protein, Young Adult, 80 and over, Mendelian randomization, Genetics, Humans, 2.1 Biological and endogenous factors, Aetiology, Child, Aged, Inflammation, Genetics & Heredity, genome-wide association study, system biology, Prevention, Inflammatory and immune system, DEPICT, Human Genome, Middle Aged, Mendelian Randomization Analysis, Biological Sciences, schizophrenia, Good Health and Well Being, Liver, Genetic Loci, Female, inflammatory disorders, Metabolic Networks and Pathways, Biomarkers, coronary artery disease, LifeLines Cohort Study
Abstract

C-reactive protein (CRP) is a sensitive biomarker of chronic low-grade inflammation and is associated with multiple complex diseases. The genetic determinants of chronic inflammation remain largely unknown, and the causal role of CRP in several clinical outcomes is debated. We performed two genome-wide association studies (GWASs), on HapMap and 1000 Genomes imputed data, of circulating amounts of CRP by using data from 88 studies comprising 204,402 European individuals. Additionally, we performed in silico functional analyses and Mendelian randomization analyses with several clinical outcomes. The GWAS meta-analyses of CRP revealed 58 distinct genetic loci (p < 5× 10-8). After adjustment for body mass index in the regression analysis, the associations at all except three loci remained. The lead variants at the distinct loci explained up to 7.0% of the variance in circulating amounts of CRP. We identified 66 gene sets that were organized in two substantially correlated clusters, one mainly composed of immune pathways and the other characterized by metabolic pathways in the liver. Mendelian randomization analyses revealed a causal protective effect of CRP on schizophrenia and a risk-increasing effect on bipolar disorder. Our findings provide further insights into the biology of inflammation and could lead to interventions for treating inflammation and its clinical consequences.

Published
2018

40. Annotating Transcriptional Effects of Genetic Variants in Disease‐Relevant Tissue: Transcriptome‐Wide Allelic Imbalance in Osteoarthritic Cartilage

Author

den Hollander, Wouter, primary, Pulyakhina, Irina, additional, Boer, Cindy, additional, Bomer, Nils, additional, van der Breggen, Ruud, additional, Arindrarto, Wibowo, additional, Couthino de Almeida, Rodrigo, additional, Lakenberg, Nico, additional, Sentner, Thom, additional, Laros, Jeroen F. J., additional, ‘t Hoen, Peter A. C., additional, Slagboom, Eline P. E., additional, Nelissen, Rob G. H. H., additional, van Meurs, Joyce, additional, Ramos, Yolande F. M., additional, and Meulenbelt, Ingrid, additional

Published
2019
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41. Increased WISP1 expression in human osteoarthritic articular cartilage is epigenetically regulated and decreases cartilage matrix production

Author

van den Bosch, Martijn H J, primary, Ramos, Yolande F M, additional, den Hollander, Wouter, additional, Bomer, Nils, additional, Nelissen, Rob G H H, additional, Bovée, Judith V M G, additional, van den Berg, Wim B, additional, van Lent, Peter L E M, additional, Blom, Arjen B, additional, van der Kraan, Peter M, additional, and Meulenbelt, Ingrid, additional

Published
2019
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42. RNA sequencing data integration reveals an miRNA interactome of osteoarthritis cartilage

Author

Coutinho de Almeida, Rodrigo, primary, Ramos, Yolande F M, additional, Mahfouz, Ahmed, additional, den Hollander, Wouter, additional, Lakenberg, Nico, additional, Houtman, Evelyn, additional, van Hoolwerff, Marcella, additional, Suchiman, H Eka D, additional, Rodríguez Ruiz, Alejandro, additional, Slagboom, P Eline, additional, Mei, Hailiang, additional, Kiełbasa, Szymon M, additional, Nelissen, Rob G H H, additional, Reinders, Marcel, additional, and Meulenbelt, Ingrid, additional

Published
2018
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43. RNA sequencing data integration reveals an miRNA interactome of osteoarthritis cartilage

Author

Coutinho de Almeida, Rodrigo (author), Ramos, Yolande F.M. (author), Mahfouz, A.M.E.T.A. (author), den Hollander, Wouter (author), Lakenberg, Nico (author), Houtman, Evelyn (author), van Hoolwerff, Marcella (author), Suchiman, H. Eka D. (author), Rodriguez-Ruiz, Alejandro (author), Slagboom, P. Eline (author), Mei, Hailiang (author), Kielbasa, Szymon M. (author), Nelissen, R.G.H.H. (author), Reinders, M.J.T. (author), Meulenbelt, Ingrid (author), Coutinho de Almeida, Rodrigo (author), Ramos, Yolande F.M. (author), Mahfouz, A.M.E.T.A. (author), den Hollander, Wouter (author), Lakenberg, Nico (author), Houtman, Evelyn (author), van Hoolwerff, Marcella (author), Suchiman, H. Eka D. (author), Rodriguez-Ruiz, Alejandro (author), Slagboom, P. Eline (author), Mei, Hailiang (author), Kielbasa, Szymon M. (author), Nelissen, R.G.H.H. (author), Reinders, M.J.T. (author), and Meulenbelt, Ingrid (author)

Abstract

Objective To uncover the microRNA (miRNA) interactome of the osteoarthritis (OA) pathophysiological process in the cartilage. Methods We performed RNA sequencing in 130 samples (n=35 and n=30 pairs for messenger RNA (mRNA) and miRNA, respectively) on macroscopically preserved and lesioned OA cartilage from the same patient and performed differential expression (DE) analysis of miRNA and mRNAs. To build an OA-specific miRNA interactome, a prioritisation scheme was applied based on inverse Pearson’s correlations and inverse DE of miRNAs and mRNAs. Subsequently, these were filtered by those present in predicted (TargetScan/microT-CDS) and/or experimentally validated (miRTarBase/TarBase) public databases. Pathway enrichment analysis was applied to elucidate OA-related pathways likely mediated by miRNA regulatory mechanisms. Results We found 142 miRNAs and 2387 mRNAs to be differentially expressed between lesioned and preserved OA articular cartilage. After applying prioritisation towards likely miRNA-mRNA targets, a regulatory network of 62 miRNAs targeting 238 mRNAs was created. Subsequent pathway enrichment analysis of these mRNAs (or genes) elucidated that genes within the ‘nervous system development’ are likely mediated by miRNA regulatory mechanisms (familywise error=8.4×10−5). Herein NTF3 encodes neurotrophin-3, which controls survival and differentiation of neurons and which is closely related to the nerve growth factor. Conclusions By an integrated approach of miRNA and mRNA sequencing data of OA cartilage, an OA miRNA interactome and related pathways were elucidated. Our functional data demonstrated interacting levels at which miRNA affects expression of genes in the cartilage and exemplified the complexity of functionally validating a network of genes that may be targeted by multiple miRNAs., Pattern Recognition and Bioinformatics

Published
2018
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45. Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury

Author

Copple, Ian M., primary, den Hollander, Wouter, additional, Callegaro, Giulia, additional, Mutter, Fiona E., additional, Maggs, James L., additional, Schofield, Amy L., additional, Rainbow, Lucille, additional, Fang, Yongxiang, additional, Sutherland, Jeffrey J., additional, Ellis, Ewa C., additional, Ingelman-Sundberg, Magnus, additional, Fenwick, Stephen W., additional, Goldring, Christopher E., additional, van de Water, Bob, additional, Stevens, James L., additional, and Park, B. Kevin, additional

Published
2018
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46. Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

Author

Ligthart, Symen, primary, Vaez, Ahmad, additional, Võsa, Urmo, additional, Stathopoulou, Maria G., additional, de Vries, Paul S., additional, Prins, Bram P., additional, Van der Most, Peter J., additional, Tanaka, Toshiko, additional, Naderi, Elnaz, additional, Rose, Lynda M., additional, Wu, Ying, additional, Karlsson, Robert, additional, Barbalic, Maja, additional, Lin, Honghuang, additional, Pool, René, additional, Zhu, Gu, additional, Macé, Aurélien, additional, Sidore, Carlo, additional, Trompet, Stella, additional, Mangino, Massimo, additional, Sabater-Lleal, Maria, additional, Kemp, John P., additional, Abbasi, Ali, additional, Kacprowski, Tim, additional, Verweij, Niek, additional, Smith, Albert V., additional, Huang, Tao, additional, Marzi, Carola, additional, Feitosa, Mary F., additional, Lohman, Kurt K., additional, Kleber, Marcus E., additional, Milaneschi, Yuri, additional, Mueller, Christian, additional, Huq, Mahmudul, additional, Vlachopoulou, Efthymia, additional, Lyytikäinen, Leo-Pekka, additional, Oldmeadow, Christopher, additional, Deelen, Joris, additional, Perola, Markus, additional, Zhao, Jing Hua, additional, Feenstra, Bjarke, additional, Amini, Marzyeh, additional, Lahti, Jari, additional, Schraut, Katharina E., additional, Fornage, Myriam, additional, Suktitipat, Bhoom, additional, Chen, Wei-Min, additional, Li, Xiaohui, additional, Nutile, Teresa, additional, Malerba, Giovanni, additional, Luan, Jian’an, additional, Bak, Tom, additional, Schork, Nicholas, additional, Del Greco M., Fabiola, additional, Thiering, Elisabeth, additional, Mahajan, Anubha, additional, Marioni, Riccardo E., additional, Mihailov, Evelin, additional, Eriksson, Joel, additional, Ozel, Ayse Bilge, additional, Zhang, Weihua, additional, Nethander, Maria, additional, Cheng, Yu-Ching, additional, Aslibekyan, Stella, additional, Ang, Wei, additional, Gandin, Ilaria, additional, Yengo, Loïc, additional, Portas, Laura, additional, Kooperberg, Charles, additional, Hofer, Edith, additional, Rajan, Kumar B., additional, Schurmann, Claudia, additional, den Hollander, Wouter, additional, Ahluwalia, Tarunveer S., additional, Zhao, Jing, additional, Draisma, Harmen H.M., additional, Ford, Ian, additional, Timpson, Nicholas, additional, Teumer, Alexander, additional, Huang, Hongyan, additional, Wahl, Simone, additional, Liu, YongMei, additional, Huang, Jie, additional, Uh, Hae-Won, additional, Geller, Frank, additional, Joshi, Peter K., additional, Yanek, Lisa R., additional, Trabetti, Elisabetta, additional, Lehne, Benjamin, additional, Vozzi, Diego, additional, Verbanck, Marie, additional, Biino, Ginevra, additional, Saba, Yasaman, additional, Meulenbelt, Ingrid, additional, O’Connell, Jeff R., additional, Laakso, Markku, additional, Giulianini, Franco, additional, Magnusson, Patrik K.E., additional, Ballantyne, Christie M., additional, Hottenga, Jouke Jan, additional, Montgomery, Grant W., additional, Rivadineira, Fernando, additional, Rueedi, Rico, additional, Steri, Maristella, additional, Herzig, Karl-Heinz, additional, Stott, David J., additional, Menni, Cristina, additional, Frånberg, Mattias, additional, St. Pourcain, Beate, additional, Felix, Stephan B., additional, Pers, Tune H., additional, Bakker, Stephan J.L., additional, Kraft, Peter, additional, Peters, Annette, additional, Vaidya, Dhananjay, additional, Delgado, Graciela, additional, Smit, Johannes H., additional, Großmann, Vera, additional, Sinisalo, Juha, additional, Seppälä, Ilkka, additional, Williams, Stephen R., additional, Holliday, Elizabeth G., additional, Moed, Matthijs, additional, Langenberg, Claudia, additional, Räikkönen, Katri, additional, Ding, Jingzhong, additional, Campbell, Harry, additional, Sale, Michele M., additional, Chen, Yii-Der I., additional, James, Alan L., additional, Ruggiero, Daniela, additional, Soranzo, Nicole, additional, Hartman, Catharina A., additional, Smith, Erin N., additional, Berenson, Gerald S., additional, Fuchsberger, Christian, additional, Hernandez, Dena, additional, Tiesler, Carla M.T., additional, Giedraitis, Vilmantas, additional, Liewald, David, additional, Fischer, Krista, additional, Mellström, Dan, additional, Larsson, Anders, additional, Wang, Yunmei, additional, Scott, William R., additional, Lorentzon, Matthias, additional, Beilby, John, additional, Ryan, Kathleen A., additional, Pennell, Craig E., additional, Vuckovic, Dragana, additional, Balkau, Beverly, additional, Concas, Maria Pina, additional, Schmidt, Reinhold, additional, Mendes de Leon, Carlos F., additional, Bottinger, Erwin P., additional, Kloppenburg, Margreet, additional, Paternoster, Lavinia, additional, Boehnke, Michael, additional, Musk, A.W., additional, Willemsen, Gonneke, additional, Evans, David M., additional, Madden, Pamela A.F., additional, Kähönen, Mika, additional, Kutalik, Zoltán, additional, Zoledziewska, Magdalena, additional, Karhunen, Ville, additional, Kritchevsky, Stephen B., additional, Sattar, Naveed, additional, Lachance, Genevieve, additional, Clarke, Robert, additional, Harris, Tamara B., additional, Raitakari, Olli T., additional, Attia, John R., additional, van Heemst, Diana, additional, Kajantie, Eero, additional, Sorice, Rossella, additional, Gambaro, Giovanni, additional, Scott, Robert A., additional, Hicks, Andrew A., additional, Ferrucci, Luigi, additional, Standl, Marie, additional, Lindgren, Cecilia M., additional, Starr, John M., additional, Karlsson, Magnus, additional, Lind, Lars, additional, Li, Jun Z., additional, Chambers, John C., additional, Mori, Trevor A., additional, de Geus, Eco J.C.N., additional, Heath, Andrew C., additional, Martin, Nicholas G., additional, Auvinen, Juha, additional, Buckley, Brendan M., additional, de Craen, Anton J.M., additional, Waldenberger, Melanie, additional, Strauch, Konstantin, additional, Meitinger, Thomas, additional, Scott, Rodney J., additional, McEvoy, Mark, additional, Beekman, Marian, additional, Bombieri, Cristina, additional, Ridker, Paul M., additional, Mohlke, Karen L., additional, Pedersen, Nancy L., additional, Morrison, Alanna C., additional, Boomsma, Dorret I., additional, Whitfield, John B., additional, Strachan, David P., additional, Hofman, Albert, additional, Vollenweider, Peter, additional, Cucca, Francesco, additional, Jarvelin, Marjo-Riitta, additional, Jukema, J. Wouter, additional, Spector, Tim D., additional, Hamsten, Anders, additional, Zeller, Tanja, additional, Uitterlinden, André G., additional, Nauck, Matthias, additional, Gudnason, Vilmundur, additional, Qi, Lu, additional, Grallert, Harald, additional, Borecki, Ingrid B., additional, Rotter, Jerome I., additional, März, Winfried, additional, Wild, Philipp S., additional, Lokki, Marja-Liisa, additional, Boyle, Michael, additional, Salomaa, Veikko, additional, Melbye, Mads, additional, Eriksson, Johan G., additional, Wilson, James F., additional, Penninx, Brenda W.J.H., additional, Becker, Diane M., additional, Worrall, Bradford B., additional, Gibson, Greg, additional, Krauss, Ronald M., additional, Ciullo, Marina, additional, Zaza, Gianluigi, additional, Wareham, Nicholas J., additional, Oldehinkel, Albertine J., additional, Palmer, Lyle J., additional, Murray, Sarah S., additional, Pramstaller, Peter P., additional, Bandinelli, Stefania, additional, Heinrich, Joachim, additional, Ingelsson, Erik, additional, Deary, Ian J., additional, Mägi, Reedik, additional, Vandenput, Liesbeth, additional, van der Harst, Pim, additional, Desch, Karl C., additional, Kooner, Jaspal S., additional, Ohlsson, Claes, additional, Hayward, Caroline, additional, Lehtimäki, Terho, additional, Shuldiner, Alan R., additional, Arnett, Donna K., additional, Beilin, Lawrence J., additional, Robino, Antonietta, additional, Froguel, Philippe, additional, Pirastu, Mario, additional, Jess, Tine, additional, Koenig, Wolfgang, additional, Loos, Ruth J.F., additional, Evans, Denis A., additional, Schmidt, Helena, additional, Smith, George Davey, additional, Slagboom, P. Eline, additional, Eiriksdottir, Gudny, additional, Morris, Andrew P., additional, Psaty, Bruce M., additional, Tracy, Russell P., additional, Nolte, Ilja M., additional, Boerwinkle, Eric, additional, Visvikis-Siest, Sophie, additional, Reiner, Alex P., additional, Gross, Myron, additional, Bis, Joshua C., additional, Franke, Lude, additional, Franco, Oscar H., additional, Benjamin, Emelia J., additional, Chasman, Daniel I., additional, Dupuis, Josée, additional, Snieder, Harold, additional, Dehghan, Abbas, additional, Alizadeh, Behrooz Z., additional, Boezen, H. Marike, additional, Navis, Gerjan, additional, Rots, Marianne, additional, Swertz, Morris, additional, Wolffenbuttel, Bruce H.R., additional, Wijmenga, Cisca, additional, Benjamin, Emelia, additional, Ahluwalia, Tarunveer Singh, additional, Meigs, James, additional, Tracy, Russell, additional, Ligthart, Symen, additional, Bis, Josh, additional, Pankratz, Nathan, additional, Rainer, Alex, additional, Wilson, James G., additional, Dupuis, Josee, additional, Prins, Bram, additional, Vaso, Urmo, additional, Stathopoulou, Maria, additional, Lehtimaki, Terho, additional, Jamshidi, Yalda, additional, Siest, Sophie, additional, Uitterlinden, Andre G., additional, Abdollahi, Mohammadreza, additional, Schnabel, Renate, additional, Schick, Ursula M., additional, Kraja, Aldi, additional, Hsu, Yi-Hsiang, additional, Tylee, Daniel S., additional, Zwicker, Alyson, additional, Uher, Rudolf, additional, Davey-Smith, George, additional, Hicks, Andrew, additional, van Duijn, Cornelia M., additional, Ward-Caviness, Cavin, additional, Rotter, J., additional, Rice, Ken, additional, Lange, Leslie, additional, de Geus, Eco, additional, Makela, Kari Matti, additional, Stacey, David, additional, Eriksson, Johan, additional, Frayling, Tim M., additional, and Slagboom, Eline P., additional

Published
2018
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49. Surveillance of premalignant gastric lesions: a multicentre prospective cohort study from low incidence regions

Author

den Hollander, Wouter J, primary, Holster, I Lisanne, additional, den Hoed, Caroline M, additional, Capelle, Lisette G, additional, Tang, Tjon J, additional, Anten, Marie-Paule, additional, Prytz-Berset, Ingrid, additional, Witteman, Ellen M, additional, ter Borg, Frank, additional, Hartog, Gijsbert den, additional, Bruno, Marco J, additional, Peppelenbosch, Maikel Petrus, additional, Lesterhuis, Wilco, additional, Doukas, Michael, additional, Kuipers, Ernst J, additional, and Spaander, Manon C W, additional

Published
2018
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