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2. Optimization of the Simple One-Step Stool Processing Method to Diagnose Tuberculosis: Evaluation of Robustness and Stool Transport Conditions for Global Implementation

Author

Yenew, Bazezew, primary, de Haas, Petra, additional, Diriba, Getu, additional, Kebede, Abebaw, additional, Sherefdin, Bihil, additional, Demissie, Yohannes, additional, Bedru, Ahmed, additional, Sahile, Mamush, additional, Mengesha, Endale, additional, Dememew, Zewdu Gashu, additional, Tegegn, Ben, additional, Slyzkyi, Andrii, additional, Amare, Misikir, additional, Getahun, Muluwork, additional, Abdella, Saro, additional, Jerene, Degu, additional, and Tiemersma, Edine, additional

Published
2023
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4. The Simple One-step stool processing method for detection of Pulmonary tuberculosis: A study protocol to assess the robustness, stool storage conditions and sampling strategy for global implementation and scale-up

Author

de Haas, Petra, primary, Yenew, Bazezew, additional, Diriba, Getu, additional, Amare, Misikir, additional, Slyzkyi, Andrii, additional, Demissie, Yohannes, additional, Sherefdin, Bihil, additional, Bedru, Ahmed, additional, Mengesha, Endale, additional, Dememew, Zewdu Gashu, additional, Kebede, Abebaw, additional, Getahun, Muluwork, additional, Tiemersma, Edine, additional, and Jerene, Degu, additional

Published
2022
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6. Predictors of HIV testing among youth 15–24 years in urban Ethiopia, 2017–2018 Ethiopia population-based HIV impact assessment.

Author

Ajiboye, Aderonke S., Eshetu, Frehywot, Lulseged, Sileshi, Getaneh, Yimam, Tademe, Nadew, Kifle, Tsigereda, Bray, Rachel, Eshete, Hailegnaw, Demissie, Yohannes, Dykewicz, Clare A., and Hoos, David

Subjects
DIAGNOSIS of HIV infections, YOUNG adults, HIV, TEENAGE boys, DEMOGRAPHIC characteristics, PRENATAL care, HIV status, LOGISTIC regression analysis
Abstract

Introduction: Youth (adolescents and young adults) aged 15–24 years comprise approximately 22% of Ethiopia's total population and make up 0.73% of HIV cases in urban Ethiopia. However, only 63% of HIV-positive youth are aware of their HIV status. We describe the HIV testing behaviors of youth 15–24 years and determined the characteristics of those who were most likely to be tested for HIV within the past year. Methods: Using data from the 2017–2018 Ethiopia Population-based HIV Impact Assessment, we provide survey-weighted estimates and prevalence risk ratios for engagement in HIV testing in the 12 months preceding the survey. We model the likelihood of HIV testing one year or more before the survey compared to never testing, using a multinomial logistic regression model. Results: Among HIV-negative and unaware HIV-positive youth 15–24 years old (N = 7,508), 21.8% [95% Confidence Interval (CI): 20.4–23.3%] reported testing for HIV in the last 12 months. Female youth [Prevalence Ratio (PR) = 1.6, 95% CI: 1.4–1.8], those aged 20–24 years (PR = 2.6, 95% CI:2.3–2.9), and those ever married (PR = 2.8, 95% CI: 2.5–3.1) were more likely to have tested for HIV within the last year. Adjusting for select demographic characteristics, sex with a non-spousal or non-live-in partner [Relative Risk (RR) = 0.3, 95% CI:0.1–0.8] among males did not increase their likelihood to test for HIV in the prior 12 months. Female youth engaged in antenatal care (RR = 3.0, 95% CI: 1.7–5.3) were more likely to test for HIV in the past year. Conclusion: The Ethiopian HIV case finding strategy may consider approaches for reaching untested youth, with a specific focus on adolescent males,15–19 years of age. This is critical towards achieving the UNAIDS HIV testing goal of 95% of all individuals living with HIV aware of their status by 2030. [ABSTRACT FROM AUTHOR]

Published
2023
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7. Assessing the Practice of Birth Defect Registration at Addis Ababa Health Facilities

Author

Eshete, Mekonen, Abate, Fikre, Abera, Berhane, Hailu, Abiye, Demissie, Yohannes, Mossey, Peter, and Butali, Azeez

Subjects
Birth defect, Registration, Pregnancy, surveillance, Infant, Newborn, Parturition, Quality of Life, Humans, Original Article, Female, Ethiopia, Health Facilities, Retrospective Studies
Abstract

Background Birth defects are conditions that exist at birth and cause structural changes in one or more parts of the body. In order to plan proper management and design preventive activities of these conditions, accurate tracking, registration and analyses of the registered data are important. We assessed the practice of birth defect registration at Addis Ababa health facilities. Methods We retrospectively checked the existence of a separate birth defect registry book and assessed the delivery room registration book for completeness in registering birth defects. We also assessed the total number of birth defects registered during 2010–2015. Results We assessed the practice of birth defect registration at 37 delivery service providing health facilities in Addis Ababa, 20 public and 17 private institutions. Of the 37 health institutions assessed, 23 registered birth defects (3 of them used a separate birth defect registry books, and 20 used a regular registration book to register birth defects). The remaining 14 did not register any congenital anomaly. Of the institutions that do not register congenital anomalies, 10 are private and four are public. Conclusion Only three delivery providing health facilities had a dedicated birth defect registry book which is close to ideal for a birth defect registration. There is a need for others to do the same until an electronic birth defect registration is established. This registration will serve as a resource for clinical governance and studies into quality of life, quality of care, etiology and prevention.

Published
2021

11. Genomic analyses in African populations identify novel risk loci for cleft palate

Author

Butali, Azeez, primary, Mossey, Peter A, additional, Adeyemo, Wasiu L, additional, Eshete, Mekonen A, additional, Gowans, Lord J J, additional, Busch, Tamara D, additional, Jain, Deepti, additional, Yu, Wenjie, additional, Huan, Liu, additional, Laurie, Cecelia A, additional, Laurie, Cathy C, additional, Nelson, Sarah, additional, Li, Mary, additional, Sanchez-Lara, Pedro A, additional, Magee, William P, additional, Magee, Kathleen S, additional, Auslander, Allyn, additional, Brindopke, Frederick, additional, Kay, Denise M, additional, Caggana, Michele, additional, Romitti, Paul A, additional, Mills, James L, additional, Audu, Rosemary, additional, Onwuamah, Chika, additional, Oseni, Ganiyu O, additional, Owais, Arwa, additional, James, Olutayo, additional, Olaitan, Peter B, additional, Aregbesola, Babatunde S, additional, Braimah, Ramat O, additional, Oginni, Fadekemi O, additional, Oladele, Ayodeji O, additional, Bello, Saidu A, additional, Rhodes, Jennifer, additional, Shiang, Rita, additional, Donkor, Peter, additional, Obiri-Yeboah, Solomon, additional, Arthur, Fareed Kow Nanse, additional, Twumasi, Peter, additional, Agbenorku, Pius, additional, Plange-Rhule, Gyikua, additional, Oti, Alexander Acheampong, additional, Ogunlewe, Olugbenga M, additional, Oladega, Afisu A, additional, Adekunle, Adegbayi A, additional, Erinoso, Akinwunmi O, additional, Adamson, Olatunbosun O, additional, Elufowoju, Abosede A, additional, Ayelomi, Oluwanifemi I, additional, Hailu, Taiye, additional, Hailu, Abiye, additional, Demissie, Yohannes, additional, Derebew, Miliard, additional, Eliason, Steve, additional, Romero-Bustillous, Miguel, additional, Lo, Cynthia, additional, Park, James, additional, Desai, Shaan, additional, Mohammed, Muiawa, additional, Abate, Firke, additional, Abdur-Rahman, Lukman O, additional, Anand, Deepti, additional, Saadi, Irfaan, additional, Oladugba, Abimibola V, additional, Lachke, Salil A, additional, Amendt, Brad A, additional, Rotimi, Charles N, additional, Marazita, Mary L, additional, Cornell, Robert A, additional, Murray, Jeffrey C, additional, and Adeyemo, Adebowale A, additional

Published
2018
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12. Oral Health–Related Quality of Life of Children Born With Orofacial Clefts in Ethiopia and Their Parents

Author

Abebe, Mekonen Eshete, primary, Deressa, Wakgari, additional, Oladugba, Victoria, additional, Owais, Arwa, additional, Hailu, Taye, additional, Abate, Fikre, additional, Hailu, Abiye, additional, Demissie, Yohannes, additional, Degu, Shiferaw, additional, Alemayehu, Bezuwork, additional, Gessesse, Mulualem, additional, Deribew, Milliard, additional, Gravem, Paul Egl, additional, Mossey, Peter, additional, and Butali, Azeez, additional

Published
2018
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15. Experiences establishing a new speech-language pathology training program in Ethiopia, a resource-limited setting: Lessons learned.

Author

Ganek, Hillary, Ab, Abiye Gebre, Abate, Fikre, Abera, Berhane, Demissie, Hanna, Demissie, Yohannes, Habte, Mesay Gebrehanna, Gravem, Paul Egil, Hakonsen, Hanna, Haye, Alemayehu Teklemariam, Holmefjord, Anders, Mollenhauer, Courtney, Rose, Marci, Shepherd, Tracy, Wadhwaniya, Zuleikha, and Eshete, Mekonen

Subjects
*SPEECH-language pathology, *RESOURCE-limited settings, *COMMUNICATIVE disorders, *MIDDLE-income countries, *GRADUATE education
Abstract

AbstractPurposeMethodResultConclusionEthiopia is the second most populous country in sub-Saharan Africa. While Ethiopia’s health care system includes primary health centres, general, and specialised hospitals, allied health care like speech-language pathology was not available until 2003. This article was written with the aim of sharing the experience of establishing speech-language pathology as a profession and the first speech-language pathology training program in Ethiopia.In this paper, we retrospectively examine how the leadership of local stakeholders, a multidisciplinary team, and the development of a professional infrastructure led to the success of the program. The authorship group, who were involved in the program from inception to implementation, share their experiences.The speech-language pathology undergraduate program at Addis Ababa University graduated its first class in 2019. Plans to grow the training program at the graduate level are ongoing.This novel program, grown from several international partnerships, is an example of how low- and middle-income countries can improve access to the service providers necessary to treat their populations. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Genomic analyses in African populations identify novel risk loci for cleft palate.

Author

Butali A, Mossey PA, Adeyemo WL, Eshete MA, Gowans LJJ, Busch TD, Jain D, Yu W, Huan L, Laurie CA, Laurie CC, Nelson S, Li M, Sanchez-Lara PA, Magee WP, Magee KS, Auslander A, Brindopke F, Kay DM, Caggana M, Romitti PA, Mills JL, Audu R, Onwuamah C, Oseni GO, Owais A, James O, Olaitan PB, Aregbesola BS, Braimah RO, Oginni FO, Oladele AO, Bello SA, Rhodes J, Shiang R, Donkor P, Obiri-Yeboah S, Arthur FKN, Twumasi P, Agbenorku P, Plange-Rhule G, Oti AA, Ogunlewe OM, Oladega AA, Adekunle AA, Erinoso AO, Adamson OO, Elufowoju AA, Ayelomi OI, Hailu T, Hailu A, Demissie Y, Derebew M, Eliason S, Romero-Bustillous M, Lo C, Park J, Desai S, Mohammed M, Abate F, Abdur-Rahman LO, Anand D, Saadi I, Oladugba AV, Lachke SA, Amendt BA, Rotimi CN, Marazita ML, Cornell RA, Murray JC, and Adeyemo AA

Subjects
Alleles, Animals, Chromosome Mapping, Disease Models, Animal, Enhancer Elements, Genetic, Female, Gene Expression, Gene Frequency, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Male, Mice, Odds Ratio, Polymorphism, Single Nucleotide, Black People genetics, Cleft Palate genetics, Genetics, Population, Genome, Human, Genomics methods, Quantitative Trait Loci
Abstract

Orofacial clefts are common developmental disorders that pose significant clinical, economical and psychological problems. We conducted genome-wide association analyses for cleft palate only (CPO) and cleft lip with or without palate (CL/P) with ~17 million markers in sub-Saharan Africans. After replication and combined analyses, we identified novel loci for CPO at or near genome-wide significance on chromosomes 2 (near CTNNA2) and 19 (near SULT2A1). In situ hybridization of Sult2a1 in mice showed expression of SULT2A1 in mesenchymal cells in palate, palatal rugae and palatal epithelium in the fused palate. The previously reported 8q24 was the most significant locus for CL/P in our study, and we replicated several previously reported loci including PAX7 and VAX1., (Published by Oxford University Press 2018.)

Published
2019
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