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1. Correction: Need for ICU and outcome of critically ill patients with COVID-19 and haematological malignancies: results from the EPICOVIDEHA survey

Author

Lahmer, Tobias, Salmanton-García, Jon, Marchesi, Francesco, El-Ashwah, Shaimaa, Nucci, Marcio, Besson, Caroline, Itri, Federico, Jaksic, Ozren, Čolović, Natasha, Weinbergerová, Barbora, Seval, Guldane Cengiz, Adžić-Vukičević, Tatjana, Szotkowski, Tomáš, Sili, Uluhan, Dargenio, Michelina, van Praet, Jens, van Doesum, Jaap, Schönlein, Martin, Ráčil, Zdeněk, Žák, Pavel, Poulsen, Christian Bjørn, Magliano, Gabriele, Jiménez, Moraima, Bonuomo, Valentina, Piukovics, Klára, Dragonetti, Giulia, Demirkan, Fatih, Blennow, Ola, Valković, Toni, Gomes Da Silva, Maria, Maertens, Johan, Glenthøj, Andreas, Fernández, Noemí, Bergantim, Rui, Verga, Luisa, Petzer, Verena, Omrani, Ali S., Méndez, Gustavo-Adolfo, Machado, Marina, Ledoux, Marie-Pierre, Bailén, Rebeca, Duarte, Rafael F., Del Principe, Maria Ilaria, Farina, Francesca, Martín-Pérez, Sonia, Dávila-Valls, Julio, Marchetti, Monia, Bilgin, Yavuz M., Fracchiolla, Nicola S., Cattaneo, Chiara, Espigado, Ildefonso, Cordoba, Raul, Collins, Graham P., Labrador, Jorge, Falces-Romero, Iker, Prezioso, Lucia, Meers, Stef, Passamonti, Francesco, Buquicchio, Caterina, López-García, Alberto, Kulasekararaj, Austin, Ormazabal-Vélez, Irati, Cuccaro, Annarosa, Garcia-Vidal, Carolina, Busca, Alessandro, Navrátil, Milan, de Jonge, Nick, Biernat, Monika M., Guidetti, Anna, Abu-Zeinah, Ghaith, Samarkos, Michail, Anastasopoulou, Amalia, de Ramón, Cristina, González-López, Tomás José, Hoenigl, Martin, Finizio, Olimpia, Pinczés, László Imre, Ali, Natasha, Vena, Antonio, Tascini, Carlo, Stojanoski, Zlate, Merelli, Maria, Emarah, Ziad, Kohn, Milena, Barać, Aleksandra, Mladenović, Miloš, Mišković, Bojana, Ilhan, Osman, Çolak, Gökçe Melis, Čerňan, Martin, Gräfe, Stefanie K., Ammatuna, Emanuele, Hanakova, Michaela, Víšek, Benjamín, Cabirta, Alba, Nordlander, Anna, Nunes Rodrigues, Raquel, Hersby, Ditte Stampe, Zambrotta, Giovanni Paolo Maria, Wolf, Dominik, Núñez-Martín-Buitrago, Lucía, Arellano, Elena, Aiello, Tommaso Francesco, García-Sanz, Ramón, Prattes, Juergen, Egger, Matthias, Limongelli, Alessandro, Bavastro, Martina, Cvetanoski, Milche, Dibos, Miriam, Rasch, Sebastian, Rahimli, Laman, Cornely, Oliver A., and Pagano, Livio

Published
2024
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2. Need for ICU and outcome of critically ill patients with COVID-19 and haematological malignancies: results from the EPICOVIDEHA survey

Author

Lahmer, Tobias, Salmanton-García, Jon, Marchesi, Francesco, El-Ashwah, Shaimaa, Nucci, Marcio, Besson, Caroline, Itri, Federico, Jaksic, Ozren, Čolović, Natasha, Weinbergerová, Barbora, Seval, Guldane Cengiz, Adžić-Vukičević, Tatjana, Szotkowski, Tomáš, Sili, Uluhan, Dargenio, Michelina, van Praet, Jens, van Doesum, Jaap, Schönlein, Martin, Ráčil, Zdeněk, Žák, Pavel, Poulsen, Christian Bjørn, Magliano, Gabriele, Jiménez, Moraima, Bonuomo, Valentina, Piukovics, Klára, Dragonetti, Giulia, Demirkan, Fatih, Blennow, Ola, Valković, Toni, Gomes Da Silva, Maria, Maertens, Johan, Glenthøj, Andreas, Fernández, Noemí, Bergantim, Rui, Verga, Luisa, Petzer, Verena, Omrani, Ali S., Méndez, Gustavo-Adolfo, Machado, Marina, Ledoux, Marie-Pierre, Bailén, Rebeca, Duarte, Rafael F., Del Principe, Maria Ilaria, Farina, Francesca, Martín-Pérez, Sonia, Dávila-Valls, Julio, Marchetti, Monia, Bilgin, Yavuz M., Fracchiolla, Nicola S., Cattaneo, Chiara, Espigado, Ildefonso, Cordoba, Raul, Collins, Graham P., Labrador, Jorge, Falces-Romero, Iker, Prezioso, Lucia, Meers, Stef, Passamonti, Francesco, Buquicchio, Caterina, López-García, Alberto, Kulasekararaj, Austin, Ormazabal-Vélez, Irati, Cuccaro, Annarosa, Garcia-Vidal, Carolina, Busca, Alessandro, Navrátil, Milan, de Jonge, Nick, Biernat, Monika M., Guidetti, Anna, Abu-Zeinah, Ghaith, Samarkos, Michail, Anastasopoulou, Amalia, de Ramón, Cristina, González-López, Tomás José, Hoenigl, Martin, Finizio, Olimpia, Pinczés, László Imre, Ali, Natasha, Vena, Antonio, Tascini, Carlo, Stojanoski, Zlate, Merelli, Maria, Emarah, Ziad, Kohn, Milena, Barać, Aleksandra, Mladenović, Miloš, Mišković, Bojana, Ilhan, Osman, Çolak, Gökçe Melis, Čerňan, Martin, Gräfe, Stefanie K., Ammatuna, Emanuele, Hanakova, Michaela, Víšek, Benjamín, Cabirta, Alba, Nordlander, Anna, Nunes Rodrigues, Raquel, Hersby, Ditte Stampe, Zambrotta, Giovanni Paolo Maria, Wolf, Dominik, Núñez-Martín-Buitrago, Lucía, Arellano, Elena, Aiello, Tommaso Francesco, García-Sanz, Ramón, Prattes, Juergen, Egger, Matthias, Limongelli, Alessandro, Bavastro, Martina, Cvetanoski, Milche, Dibos, Miriam, Rasch, Sebastian, Rahimli, Laman, Cornely, Oliver A., and Pagano, Livio

Published
2024
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3. Breakthrough COVID-19 in vaccinated patients with hematologic malignancies: results from EPICOVIDEHA survey

Author

Pagano, Livio, Salmanton-García, Jon, Marchesi, Francesco, Blennow, Ola, da Silva, Maria Gomes, Glenthøj, Andreas, van Doesum, Jaap, Bilgin, Yavuz M, López-García, Alberto, Itri, Federico, Rodrigues, Raquel Nunes, Weinbergerová, Barbora, Farina, Francesca, Dragonetti, Giulia, Venemyr, Caroline Berg, van Praet, Jens, Jaksic, Ozren, Valković, Toni, Falces-Romero, Iker, Martín-Pérez, Sonia, Jiménez, Moraima, Dávila-Valls, Julio, Schönlein, Martin, Ammatuna, Emanuele, Meers, Stef, Delia, Mario, Stojanoski, Zlate, Nordlander, Anna, Lahmer, Tobias, Pinczés, László Imre, Buquicchio, Caterina, Piukovics, Klára, Ormazabal-Vélez, Irati, Fracchiolla, Nicola, Samarkos, Michail, Méndez, Gustavo-Adolfo, Hernández-Rivas, José-Ángel, Espigado, Ildefonso, Cernan, Martin, Petzer, Verena, Lamure, Sylvain, di Blasi, Roberta, de Almedia, Joyce Marques, Dargenio, Michelina, Biernat, Monika M, Sciumè, Mariarita, de Ramón, Cristina, de Jonge, Nick, Batinić, Josip, Aujayeb, Avinash, Marchetti, Monia, Fouquet, Guillemette, Fernández, Noemí, Zambrotta, Giovanni, Sacchi, Maria Vittoria, Guidetti, Anna, Demirkan, Fatih, Prezioso, Lucia, Ráčil, Zdeněk, Nucci, Marcio, Mladenović, Miloš, Liévin, Raphaël, Hanáková, Michaela, Gräfe, Stefanie, Sili, Uluhan, Machado, Marina, Cattaneo, Chiara, Adžić-Vukičević, Tatjana, Verga, Luisa, Labrador, Jorge, Rahimli, Laman, Bonanni, Matteo, Passamonti, Francesco, Pagliuca, Antonio, Corradini, Paolo, Hoenigl, Martin, Koehler, Philipp, Busca, Alessandro, Cornely, Oliver A, Serrano, Laura, Susana, José-María Ribera-Santa, Meletiadis, Joseph, Tsirigotis, Panagiotis, Coppola, Nicola, Mikulska, Malgorzata, Erben, Nurettin, Besson, Caroline, Merelli, Maria, González-López, Tomás-José, Loureiro-Amigo, Jorge, García-Vidal, Carolina, de Kort, Elizabeth, Cuccaro, Annarosa, Zompi, Sofia, Reizine, Florian, Finizio, Olimpia, Duléry, Rémy, Calbacho, Maria, Abu-Zeinah, Ghaith, and Malak, Sandra

Subjects
Biotechnology, Emerging Infectious Diseases, Biodefense, Immunization, Infectious Diseases, Lung, Vaccine Related, Cancer, Prevention, Good Health and Well Being, Adult, Humans, COVID-19, SARS-CoV-2, COVID-19 Testing, Hematologic Neoplasms, Antibodies, Monoclonal, Antiviral Agents, Antibodies, Viral, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Paediatrics and Reproductive Medicine, Immunology
Abstract

Limited data are available on breakthrough COVID-19 in patients with hematologic malignancy (HM) after anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. Adult patients with HM, ≥1 dose of anti-SARS-CoV-2 vaccine, and breakthrough COVID-19 between January 2021 and March 2022 were analyzed. A total of 1548 cases were included, mainly lymphoid malignancies (1181 cases, 76%). After viral sequencing in 753 cases (49%), the Omicron variant was prevalent (517, 68.7%). Most of the patients received ≤2 vaccine doses before COVID-19 (1419, 91%), mostly mRNA-based (1377, 89%). Overall, 906 patients (59%) received COVID-19-specific treatment. After 30-day follow-up from COVID-19 diagnosis, 143 patients (9%) died. The mortality rate in patients with the Omicron variant was 7.9%, comparable to other variants, with a significantly lower 30-day mortality rate than in the prevaccine era (31%). In the univariable analysis, older age (P < .001), active HM (P < .001), and severe and critical COVID-19 (P = .007 and P < .001, respectively) were associated with mortality. Conversely, patients receiving monoclonal antibodies, even for severe or critical COVID-19, had a lower mortality rate (P < .001). In the multivariable model, older age, active disease, critical COVID-19, and 2-3 comorbidities were correlated with a higher mortality, whereas monoclonal antibody administration, alone (P < .001) or combined with antivirals (P = .009), was protective. Although mortality is significantly lower than in the prevaccination era, breakthrough COVID-19 in HM is still associated with considerable mortality. Death rate was lower in patients who received monoclonal antibodies, alone or in combination with antivirals.

Published
2022

4. Decoding the historical tale: COVID-19 impact on haematological malignancy patients—EPICOVIDEHA insights from 2020 to 2022

Author

Martín-Vallejo, Francisco Javier, Zdziarski, Przemyslaw, Zarrinfer, Hossein, Wittig, Jana, Win, Sein, Wai-Man, Vivien, Víšek, Benjamín, Vinh, Donald C., Vehreschild, Maria, Varricchio, Gina, Tsirigotis, Panagiotis, Torres-Tienza, Ana, Tanase, Alina Daniela, Tafuri, Agostino, Stamouli, Maria, Sramek, Jiří, Soussain, Carole, Shirinova, Ayten, Schubert, Jörg, Schalk, Enrico, Salehi, Mohammad Reza, Saleh, Modar, Rosati, Giorgio, Roldán, Elisa, Reizine, Florian, Rêgo, Mayara, Regalado-Artamendi, Isabel, Popova, Marina, Pinto, Fernando, Philippe, Laure, Orth, Hans Martin, Ommen, Hans-Beier, Obr, Aleš, Núñez-Martín-Buitrago, Lucía, Noël, Nicolas, Neuhann, Julia, Nadali, Gianpaolo, Nacov, Julia A., Munhoz Alburquerque, Ana M., Mitra, Maria Enza, Mikulska, Malgorzata, Mellinghoff, Sibylle, Mechtel, Ben, Martín-González, Juan-Alberto, Malak, Sandra, Loureiro-Amigo, Jorge, Lorenzo De La Peña, Lisset, Liberti, Giulia, Landau, Marianne, Lacej, Ira, Kolditz, Martin, Kho, Chi Shan, Khedr, Reham Abdelaziz, Karthaus, Meinolf, Karlsson, Linda Katharina, Jiménez-Lorenzo, María-Josefa, Izuzquiza, Macarena, Hoell-Neugebauer, Baerbel, Herbrecht, Raoul, Heath, Christopher H., Guolo, Fabio, Grothe, Jan, Giordano, Antonio, Gerasymchuk, Sergey, García-Sanz, Ramón, García-Poutón, Nicole, Funke, Vaneuza Araújo Moreira, Fung, Monica, Flasshove, Charlotte, Fianchi, Luana, Essame, Jenna, Egger, Matthias, Drenou, Bernard, Dragonetti, Giulia, Desole, Maximilian, Della Pepa, Roberta, Deau Fischer, Bénédicte, De Kort, Elizabeth, De Cabo, Erik, Danion, François, Daguindau, Etienne, Cushion, Tania, Cremer, Louise, Criscuolo, Marianna, Cordini, Gregorio, Cingolani, Antonella, Ciceri, Fabio, Chowdhury, Fazle Rabbi, Chelysheva, Ekaterina, Chauchet, Adrien, Chai, Louis Yi Ann, Ceesay, M. Mansour, Busch, Elena, Brehon, Mathias, Borducchi, Davimar M.M., Booth, Stephen, Bologna, Serge, Berg Venemyr, Caroline, Bailén-Almorox, Rebeca, Antoniadou, Anastasia, Anastasopoulou, Amalia N., Altuntaş, Fevzi, Salmanton-García, Jon, Marchesi, Francesco, Farina, Francesca, Weinbergerová, Barbora, Itri, Federico, Dávila-Valls, Julio, Martín-Pérez, Sonia, Glenthøj, Andreas, Hersby, Ditte Stampe, Gomes Da Silva, Maria, Nunes Rodrigues, Raquel, López-García, Alberto, Córdoba, Raúl, Bilgin, Yavuz M., Falces-Romero, Iker, El-Ashwah, Shaimaa, Emarah, Ziad, Besson, Caroline, Kohn, Milena, Van Doesum, Jaap, Ammatuna, Emanuele, Marchetti, Monia, Labrador, Jorge, Zambrotta, Giovanni Paolo Maria, Verga, Luisa, Jaksic, Ozren, Nucci, Marcio, Piukovics, Klára, Cabirta-Touzón, Alba, Jiménez, Moraima, Arellano, Elena, Espigado, Ildefonso, Blennow, Ola, Nordlander, Anna, Meers, Stef, Vian Praet, Jens, Aiello, Tommaso Francesco, Garcia-Vidal, Carolina, Fracchiolla, Nicola S., Sciumè, Mariarita, Seval, Guldane Cengiz, Žák, Pavel, Buquicchio, Caterina, Tascini, Carlo, Gräfe, Stefanie K., Schönlein, Martin, Adžić-VUKIČEVIĆ, Tatjana, Bonuomo, Valentina, Cattaneo, Chiara, Nizamuddin, Summiya, Čerňan, Martin, Plantefeve, Gaëtan, Prin, Romane, Szotkovski, Tomas, Collins, Graham P., Dargenio, Michelina, Petzer, Verena, Wolf, Dominik, Čolović, Natasha, Prezioso, Lucia, Valković, Toni, Passamonti, Francesco, Méndez, Gustavo-Adolfo, Sili, Uluhan, Vena, Antonio, Bavastro, Martina, Limongelli, Alessandro, Duarte, Rafael F., Ledoux, Marie-Pierre, Cvetanoski, Milche, Stojanoski, Zlate, Machado, Marina, Batinić, Josip, Magliano, Gabriele, Biernat, Monika M., Pantić, Nikola, Poulsen, Christian Bjørn, Cuccaro, Annarosa, Del Principe, Maria Ilaria, Kulasekararaj, Austin, Ormazabal-Vélez, Irati, Busca, Alessandro, Demirkan, Fatih, Ijaz, Marriyam, Klimko, Nikolai, Stoma, Igor, Khostelidi, Sofya, Fernández, Noemí, Omrani, Ali S., Bergantim, Rui, De Jonge, Nick, Fouquet, Guillemette, Navrátil, Milan, Abu-Zeinah, Ghaith, Samarkos, Michail, Maertens, Johan, De Ramón, Cristina, Guidetti, Anna, Magyari, Ferenc, González-López, Tomás José, Lahmer, Tobias, Finizio, Olimpia, Ali, Natasha, Pinczés, László Imre, Lavilla-Rubira, Esperanza, Romano, Alessandra, Merelli, Maria, Delia, Mario, Calbacho, Maria, Meletiadis, Joseph, Antić, Darko, Hernández-Rivas, José-Ángel, Marques De Almeida, Joyce, Al-Khabori, Murtadha, Hoenigl, Martin, Tisi, Maria Chiara, Khanna, Nina, Barać, Aleksandra, Eisa, Noha, Di Blasi, Roberta, Liévin, Raphaël, Miranda-Castillo, Carolina, Bahr, Nathan C., Lamure, Sylvain, Papa, Mario Virgilio, Yahya, Ayel, Aujayeb, Avinash, Novák, Jan, Erben, Nurettin, Fernández-Galán, María, Ribera-Santa Susana, José-María, Rinaldi, Ikhwan, Fazzi, Rita, Piedimonte, Monica, Duléry, Rémy, Gonzaga, Yung, Soto-Silva, Andrés, Sapienza, Giuseppe, Serris, Alexandra, Drgoňa, Ľuboš, Groh, Ana, Serrano, Laura, Gavriilaki, Eleni, Tragiannidis, Athanasios, Prattes, Juergen, Coppola, Nicola, Otašević, Vladimir, Mladenović, Miloš, Mitrović, Mirjana, Mišković, Bojana, Jindra, Pavel, Zompi, Sofia, Sacchi, Maria Vittoria, Krekeler, Carolin, Shumilov, Evgenii, Infante, Maria Stefania, García-Bordallo, Daniel, Çolak, Gökçe Melis, Mayer, Jiří, Nygaard, Marietta, Hanáková, Michaela, Ráčil, Zdeněk, Quattrone, Martina, Bonanni, Matteo, Koehler, Philipp, Rahimli, Laman, Cornely, Oliver A., and Pagano, Livio

Published
2024
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5. Activity of venetoclax in patients with relapsed or refractory chronic lymphocytic leukaemia: analysis of the VENICE-1 multicentre, open-label, single-arm, phase 3b trial

Author

Kater, Arnon P, Arslan, Önder, Demirkan, Fatih, Herishanu, Yair, Ferhanoglu, Burhan, Diaz, Marcos Gonzalez, Leber, Brian, Montillo, Marco, Panayiotidis, Panayiotis, Rossi, Davide, Skarbnik, Alan, Tempescul, Adrian, Turgut, Mehmet, Mellink, Clemens H, van der Kevie-Kersemaekers, Anne-Marie F, Lanham, Stuart, Sale, Ben, Del Rio, Luis, Popovic, Relja, Chyla, Brenda J, Busman, Todd, Komlosi, Viktor, Wang, Xifeng, Sail, Kavita, Pena, German E, Vizkelety, Tamas, and Forconi, Francesco

Published
2024
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6. Predicting the next pandemic: VACCELERATE ranking of the WorldHealth Organization's Blueprint forAction toPreventEpidemics

Author

Busch, Martin, Seifert, Ulrike, Widmer, Andreas, Nagao, Miki, Rello, Jordi, Todorova, Tatina, Cviljević, Sabina, Heath, Christopher H., Jančorienė, Ligita, Fischer, Thea Koelsen, Orth, Hans Martin, Johansen, Isik Somuncu, Doymaz, Mehmet, Tragiannidis, Athanasios, Löscher, Thomas, Xu, Jin-Fu, Husa, Petr, Oteo, José Antonio, Issack, Mohammad I., Zeitlinger, Markus, Le Grand, Roger, Zdziarski, Przemysław, Demirkan, Fatih, Amador, Paloma Merino, García-Lozano, Tomás, Cao, Qing, Vázquez, Lourdes, Caeiro, Juan Pablo, Hermans, Peter, Nahrwar, Shahroch, Avsar, Korkut, Kumar, Deepak, Fernández, Norma, Mardani, Masoud, Segal, Esther, Pan, Angelo, Gkentzi, Despoina, Gioula, Georgia, Cortés, Jorge Alberto, Oliveira, Joaquim, van Damme, Pierre, Bin Mohd Zaili, Mohd Zaki, Antinori, Spinello, Zablockienė, Birutė, Papazisis, Georgios, Aneke, Chioma Inyang, Valerio, Maricela, McConkey, Samuel, Aujayeb, Avinash, Azzini, Anna Maria, Roganović, Jelena, Greve-Isdahl Mohn, Kristin, Kremsner, Peter, Gkrania-Klotsas, Effrossyni, Corzo, Dora, Khanna, Nina, Smiatacz, Tomasz, Scheithauer, Simone, Merelli, Maria, Klempa, Boris, Vrḫovac, Radovan, Ruggiero, Antonio, Chaudhary, Pankaj, Maquera-Afaray, Julio, Ekkelenkamp, Miquel, Jindra, Pavel, Pantić, Nikola, Guerra, Gemma Jiménez, Weiss, Guenter, Roohi, Behrad, Argyropoulos, Christos D., Silfverdal, Sven Aprne, van Praet, Jens, Bal, Zumrut Sahbudak, Kanj, Souha, Young, Barnaby, Pana, Zoi Dorothea, Roilides, Emmanuel, Stearns, Stephen C., Wauters, Joost, Baño, Jesús Rodríguez, Pletz, Mathias W., Travar, Maja, Kühn, Steven, Riera, Fernando, Cornely, Daniel, Laura, Vlad Jeni, Koehler, Philipp, Eley, Brian, Nair, Pravin K., Ciesek, Sandra, Olaru, Ioana Diana, Marques, Laura, Pontali, Emanuele, Naunheim, Alexandra, Lieb, Adrian, Gerhard, Markus, Farooqi, Joveria Qais, Turtle, Lance, Méndez, Gustavo Adolfo, Cox, Rebecca Jane, Goodman, Nigel, Caceca, Billie, Pemán, Javier, Dawood, Halima, Askling, Helena Hervius, Fomsgaard, Anders, Hernández, Alejandra Calderón, Staehelin, Cornelia, Liu, Chia-Ying, Icardi, Giancarlo, Castagnola, Elio, Salzer, Helmut J.F., Lundgren, Jens, Javadli, Samir, Forghieri, Fabio, Salmanton-García, Jon, Wipfler, Pauline, Leckler, Janina, Nauclér, Pontus, Mallon, Patrick W., Bruijning-Verhagen, Patricia C.J.L., Schmitt, Heinz-Joseph, Bethe, Ullrich, Olesen, Ole F., Stewart, Fiona A., Albus, Kerstin, and Cornely, Oliver A.

Published
2024
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7. Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients: EPICOVIDEHA findings

Author

MARQUES DE ALMEIDA, Joyce, HERNÁNDEZ-RIVAS, José-Ángel, GUIDETTI, Anna, FINIZIO, Olimpia, STOJANOSKI, Zlate, CVETANOSKI, Milche, MELETIADIS, Joseph, DE JONGE, Nick, ANTIĆ, Darko, ALI, Natasha, TISI, Maria Chiara, SERRANO, Laura, PLANTEFEVE, Gaëtan, KHANNA, Nina, HOENIGL, Martin, ČERŇAN, Martin, MIRANDA-CASTILLO, Carolina, FERNÁNDEZ-GALÁN, María, SERRIS, Alexandra, ERBEN, Nurettin, DULÉRY, Rémy, AUJAYEB, Avinash, PAPA, Mario Virgilio, NOVÁK, Jan, DELIA, Mario, SAPIENZA, Giuseppe, REIZINE, Florian, OMRANI, Ali S., DI BLASI, Roberta, LAMURE, Sylvain, DRGOŇA, Ľuboš, COPPOLA, Nicola, BATINIĆ, Josip, AL-KHABORI, Murtadha, RIBERA-SANTA SUSANA, José-María, PIEDIMONTE, Monica, LOUREIRO-AMIGO, Jorge, FOUQUET, Guillemette, FAZZI, Rita, DANION, François, SCHUBERT, Jörg, HOELL-NEUGEBAUER, Baerbel, BAHR, Nathan C., YAHIA, Ayel Omar, TORRES-ATIENZA, Ana, RINALDI, Ikhwan, POPOVA, Marina, OMMEN, Hans-Beier, MITRA, Maria Enza, MIKULSKA, Malgorzata, LACEJ, Ira, KHOSTELIDI, Sofya, WIN, Sein, VINH, Donald, SALEH, Modar, PRATTES, Juergen, JINDRA, Pavel, GUOLO, Fabio, DELLA PEPA, Roberta, CHELYSHEVA, Ekaterina, ZDZIARSKI, Przemyslaw, WAI-MAN, Vivien, SOTO-SILVA, Andrés, ORTH, Hans Martin, MALAK, Sandra, LORENZO DE LA PEÑA, Lisset, KOLDITZ, Martin, Shan KHO, Chi, HEATH, Christopher H., GROH, Ana, GAVRIILAKI, Eleni, FUNG, Monica, EGGER, Matthias, DE KORT, Elizabeth, DE CABO, Erik, CUSHION, Tania, CHOWDHURY, Fazle Rabbi, CEESAY, M. Mansour, BREHON, Mathias, VARRICCHIO, Gina, TAFURI, Agostino, JIMÉNEZ-LORENZO, María-Josefa, KLIMKO, Nikolai, TSIRIGOTIS, Panagiotis, ANTONIADOU, Anastasia, VEHRESCHILD, Maria, Rossi, Giuseppe, Salmanton-García, Jon, Cattaneo, Chiara, Marchesi, Francesco, Dávila-Valls, Julio, Martín-Pérez, Sonia, Itri, Federico, López-García, Alberto, Glenthøj, Andreas, Gomes da Silva, Maria, Besson, Caroline, Marchetti, Monia, Weinbergerová, Barbora, Jaksic, Ozren, Jiménez, Moraima, Bilgin, Yavuz M., Van Doesum, Jaap, Farina, Francesca, Žák, Pavel, Verga, Luisa, Collins, Graham P., Bonuomo, Valentina, Van Praet, Jens, Nucci, Marcio, Meers, Stef, Espigado, Ildefonso, Fracchiolla, Nicola S., Valković, Toni, Poulsen, Christian Bjørn, Čolović, Natasha, Dragonetti, Giulia, Ledoux, Marie-Pierre, Tascini, Carlo, Buquicchio, Caterina, Blennow, Ola, Passamonti, Francesco, Machado, Marina, Labrador, Jorge, Duarte, Rafael F., Schönlein, Martin, Prezioso, Lucia, Falces-Romero, Iker, Kulasekararaj, Austin, Garcia-Vidal, Carolina, Fernández, Noemí, Abu-Zeinah, Ghaith, Ormazabal-Vélez, Irati, Adžić-Vukičević, Tatjana, Piukovics, Klára, Stoma, Igor, Cuccaro, Annarosa, Magliano, Gabriele, Szotkowski, Tomáš, González-López, Tomás-José, El-Ashwah, Shaimaa, Bergantim, Rui, Sili, Uluhan, Maertens, Johan, Demirkan, Fatih, De Ramón, Cristina, Petzer, Verena, Del Principe, Maria Ilaria, Navrátil, Milan, Dargenio, Michelina, Seval, Guldane Cengiz, Samarkos, Michail, Ráčil, Zdeněk, Pinczés, László Imre, Lahmer, Tobias, Busca, Alessandro, Méndez, Gustavo-Adolfo, Vena, Antonio, Biernat, Monika M., Merelli, Maria, Calbacho, Maria, Barać, Aleksandra, Bavastro, Martina, Limongelli, Alessandro, Ilhan, Osman, Wolf, Dominik, Çolak, Gökçe Melis, García-Sanz, Ramón, Emarah, Ziad, Mišković, Bojana, Gräfe, Stefanie K., Mladenović, Miloš, Aiello, Tommaso Francesco, Núñez-Martín-Buitrago, Lucía, Nordlander, Anna, Arellano, Elena, Zambrotta, Giovanni Paolo Maria, Ammatuna, Emanuele, Cabirta, Alba, Sacchi, Maria Vittoria, Nunes Rodrigues, Raquel, Hersby, Ditte Stampe, Hanakova, Michaela, Rahimli, Laman, Cordoba, Raul, Cornely, Oliver A., and Pagano, Livio

Published
2023
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8. Other malignancies in the history of CLL: an international multicenter study conducted by ERIC, the European Research Initiative on CLL, in HARMONY

Author

Chatzikonstantinou, Thomas, Scarfò, Lydia, Karakatsoulis, Georgios, Minga, Eva, Chamou, Dimitra, Iacoboni, Gloria, Kotaskova, Jana, Demosthenous, Christos, Smolej, Lukas, Mulligan, Stephen, Alcoceba, Miguel, Al-Shemari, Salem, Aurran-Schleinitz, Thérèse, Bacchiarri, Francesca, Bellido, Mar, Bijou, Fontanet, Calleja, Anne, Medina, Angeles, Khan, Mehreen Ali, Cassin, Ramona, Chatzileontiadou, Sofia, Collado, Rosa, Christian, Amy, Davis, Zadie, Dimou, Maria, Donaldson, David, Santos, Gimena Dos, Dreta, Barbara, Efstathopoulou, Maria, El-Ashwah, Shaimaa, Enrico, Alicia, Fresa, Alberto, Galimberti, Sara, Galitzia, Andrea, García-Serra, Rocío, Gimeno, Eva, González-Gascón-y-Marín, Isabel, Gozzetti, Alessandro, Guarente, Valerio, Guieze, Romain, Gogia, Ajay, Gupta, Ritu, Harrop, Sean, Hatzimichael, Eleftheria, Herishanu, Yair, Hernández-Rivas, José-Ángel, Inchiappa, Luca, Jaksic, Ozren, Janssen, Susanne, Kalicińska, Elżbieta, Laribi, Kamel, Karakus, Volkan, Kater, Arnon P., Kho, Bonnie, Kislova, Maria, Konstantinou, Eliana, Koren-Michowitz, Maya, Kotsianidis, Ioannis, Kreitman, Robert J., Labrador, Jorge, Lad, Deepesh, Levin, Mark-David, Levy, Ilana, Longval, Thomas, Lopez-Garcia, Alberto, Marquet, Juan, Martin-Rodríguez, Lucia, Maynadié, Marc, Maslejova, Stanislava, Mayor-Bastida, Carlota, Mihaljevic, Biljana, Milosevic, Ivana, Miras, Fatima, Moia, Riccardo, Morawska, Marta, Murru, Roberta, Nath, Uttam Kumar, Navarro-Bailón, Almudena, Oliveira, Ana C., Olivieri, Jacopo, Oscier, David, Panovska-Stavridis, Irina, Papaioannou, Maria, Papajík, Tomas, Kubova, Zuzana, Phumphukhieo, Punyarat, Pierie, Cheyenne, Puiggros, Anna, Rani, Lata, Reda, Gianluigi, Rigolin, Gian Matteo, Ruchlemer, Rosa, Daniel de Deus Santos, Marcos, Schipani, Mattia, Schiwitza, Annett, Shen, Yandong, Simkovic, Martin, Smirnova, Svetlana, Abdelrahman Soliman, Dina Sameh, Spacek, Martin, Tadmor, Tamar, Tomic, Kristina, Tse, Eric, Vassilakopoulos, Theodoros, Visentin, Andrea, Vitale, Candida, von Tresckow, Julia, Vrachiolias, George, Vukovic, Vojin, Walewska, Renata, Wasik-Szczepanek, Ewa, Xu, Zhenshu, Yagci, Munci, Yañez, Lucrecia, Yassin, Mohamed, Zuchnicka, Jana, Angelopoulou, Maria, Antic, Darko, Biderman, Bella, Catherwood, Mark, Claus, Rainer, Coscia, Marta, Cuneo, Antonio, Demirkan, Fatih, Espinet, Blanca, Gaidano, Gianluca, Kalashnikova, Olga B., Laurenti, Luca, Nikitin, Eugene, Pangalis, Gerassimos A., Panagiotidis, Panagiotis, Popov, Viola Maria, Pospisilova, Sarka, Sportoletti, Paolo, Stavroyianni, Niki, Tam, Constantine, Trentin, Livio, Chatzidimitriou, Anastasia, Bosch, Francesc, Doubek, Michael, Ghia, Paolo, and Stamatopoulos, Kostas

Published
2023
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9. Cusatuzumab plus azacitidine in newly diagnosed acute myeloid leukaemia ineligible for intensive chemotherapy (CULMINATE): part one of a randomised, phase 2, dose optimisation study

Author

Pabst, Thomas, Papayannidis, Cristina, Demirkan, Fatih, Doronin, Vadim, Fogliatto, Laura M, Guttke, Christina, Gyan, Emmanuel, Hamad, Nada, Herrera, Pilar, Hultberg, Anna, Jacobs, Julie, Johnson, Amy J, Langlois, Angélique, Ma, Xuewen, Martinelli, Giovanni, Arnan, Montserrat, Müller, Rouven, Nottage, Kerri, Ofran, Yishai, Özcan, Muhit, Samoilova, Olga, Tolbert, Jaszianne A, Trudel, Géralyn C, Xiu, Liang, Vey, Norbert, and Wei, Andrew H

Published
2023
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10. Evaluation of Cardiac Repolarization in the Randomized Phase 2 Study of Intermediate- or High-Risk Smoldering Multiple Myeloma Patients Treated with Daratumumab Monotherapy.

Author

Chari, Ajai, Munder, Markus, Weisel, Katja, Jenner, Matthew, Bygrave, Ceri, Petrucci, Maria, Boccadoro, Mario, Cavo, Michele, van de Donk, Niels, Turgut, Mehmet, Demirkan, Fatih, Karadogan, Ihsan, Libby, Edward, Kleiman, Robert, Kuppens, Steven, Bandekar, Rajesh, Neff, Tobias, Heuck, Christoph, Qi, Ming, Clemens, Pamela, and Goldschmidt, Hartmut

Subjects
Daratumumab, Monoclonal antibody, Pharmacokinetic-pharmacodynamic analysis, QTc substudy, Smoldering multiple myeloma, Antibodies, Monoclonal, Electrocardiography, Heart Rate, Humans, Smoldering Multiple Myeloma
Abstract

INTRODUCTION: Daratumumab is a CD38-targeting monoclonal antibody that has demonstrated clinical benefit for multiple myeloma. Daratumumab inhibition of CD38, which is expressed on immune cell populations and cardiomyocytes, could potentially affect cardiac function. This QTc substudy of the phase 2 CENTAURUS study investigated the potential effect of intravenous daratumumab monotherapy on QTc prolongation and other electrocardiogram (ECG) parameters, including concentration-QTc effect modeling. METHODS: Patients had intermediate- or high-risk smoldering multiple myeloma. Patients with QT interval corrected by Fridericias formula (QTcF) > 470 ms, QRS interval ≥ 110 ms, or PR interval ≥ 200 ms were excluded. Triplicate ECGs were collected at screening, Dose 1, and Dose 8. Analyses of on-treatment ECGs were conducted with a time-matched baseline (primary analysis). By time-point, pharmacokinetic-pharmacodynamic (PK/PD), and outlier analyses were conducted. RESULTS: Of 123 patients in CENTAURUS, 31 were enrolled in the QTc substudy. Daratumumab produced a small increase in heart rate (5-12 beats per minute) of unclear significance. There was a small but clinically insignificant effect on QTc, as measured by both time-matched time-point and PK/PD analyses. The primary analysis demonstrated a maximum mean increase in QTcF of 9.1 ms (90% 2-sided upper confidence interval [CI], 14.1 ms). The primary PK/PD analysis predicted a maximum QTcF increase of 8.5 ms (90% 2-sided upper CI, 13.5 ms). No patient had an abnormal U wave, a new QTcF > 500 ms, or > 60 ms change from baseline for QTcF. CONCLUSION: Analysis of ECG intervals and concentration-QTc relationships showed a small but clinically insignificant effect of daratumumab. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02316106.

Published
2021

11. Breakthrough COVID-19 in vaccinated patients with hematologic malignancies: results from the EPICOVIDEHA survey

Author

Serrano, Laura, Ribera-Santa Susana, José-María, Meletiadis, Joseph, Tsirigotis, Panagiotis, Coppola, Nicola, Mikulska, Malgorzata, Erben, Nurettin, Besson, Caroline, Merelli, Maria, González-López, Tomás-José, Loureiro-Amigo, Jorge, García-Vidal, Carolina, Kort, Elizabeth de, Cuccaro, Annarosa, Zompi, Sofia, Reizine, Florian, Finizio, Olimpia, Duléry, Rémy, Calbacho, Maria, Abu-Zeinah, Ghaith, Malak, Sandra, Zdziarski, Przemyslaw, Varrichio, Gina, Tragiannidis, Athanasios, Plantefeve, Gaëtan, Duarte, Rafael, Danion, François, Tisi, Maria Chiara, Sakellari, Ioanna, Karthaus, Meinholf, Groh, Ana, Fung, Monica, Emarah, Ziad, Coronel-Ayala, Omar-Francisco, Ann Chai, Louis Yi, Brehon, Mathias, Bonuomo, Valentina, Wolf, Dominik, Wittig, Jana, Vehreschild, Maria, Papa, Mario Virgilio, Neuhann, Julia, Jiménez-Lorenzo, María-Josefa, Grothe, Jan, Gavriilaki, Eleni, García-Sanz, Ramón, García-Poutón, Nicole, El-Ashwah, Shaimaa Saber, Eggerer, Matthias, Cordoba, Raul, Çolak, Gökçe Melis, Arellano, Elena, Pagano, Livio, Salmanton-García, Jon, Marchesi, Francesco, Blennow, Ola, Gomes da Silva, Maria, Glenthøj, Andreas, van Doesum, Jaap, Bilgin, Yavuz M., López-García, Alberto, Itri, Federico, Nunes Rodrigues, Raquel, Weinbergerová, Barbora, Farina, Francesca, Dragonetti, Giulia, Berg Venemyr, Caroline, van Praet, Jens, Jaksic, Ozren, Valković, Toni, Falces-Romero, Iker, Martín-Pérez, Sonia, Jiménez, Moraima, Dávila-Valls, Julio, Schönlein, Martin, Ammatuna, Emanuele, Meers, Stef, Delia, Mario, Stojanoski, Zlate, Nordlander, Anna, Lahmer, Tobias, Imre Pinczés, László, Buquicchio, Caterina, Piukovics, Klára, Ormazabal-Vélez, Irati, Fracchiolla, Nicola, Samarkos, Michail, Méndez, Gustavo-Adolfo, Hernández-Rivas, José-Ángel, Espigado, Ildefonso, Cernan, Martin, Petzer, Verena, Lamure, Sylvain, di Blasi, Roberta, Marques de Almedia, Joyce, Dargenio, Michelina, Biernat, Monika M., Sciumè, Mariarita, de Ramón, Cristina, de Jonge, Nick, Batinić, Josip, Aujayeb, Avinash, Marchetti, Monia, Fouquet, Guillemette, Fernández, Noemí, Zambrotta, Giovanni, Sacchi, Maria Vittoria, Guidetti, Anna, Demirkan, Fatih, Prezioso, Lucia, Ráčil, Zdeněk, Nucci, Marcio, Mladenović, Miloš, Liévin, Raphaël, Hanáková, Michaela, Gräfe, Stefanie, Sili, Uluhan, Machado, Marina, Cattaneo, Chiara, Adžić-Vukičević, Tatjana, Verga, Luisa, Labrador, Jorge, Rahimli, Laman, Bonanni, Matteo, Passamonti, Francesco, Pagliuca, Antonio, Corradini, Paolo, Hoenigl, Martin, Koehler, Philipp, Busca, Alessandro, and Cornely, Oliver A.

Published
2022
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15. Decoding the historical tale: COVID-19 impact on haematological malignancy patients—EPICOVIDEHA insights from 2020 to 2022

Author

Salmanton-García, Jon, primary, Marchesi, Francesco, additional, Farina, Francesca, additional, Weinbergerová, Barbora, additional, Itri, Federico, additional, Dávila-Valls, Julio, additional, Martín-Pérez, Sonia, additional, Glenthøj, Andreas, additional, Hersby, Ditte Stampe, additional, Gomes Da Silva, Maria, additional, Nunes Rodrigues, Raquel, additional, López-García, Alberto, additional, Córdoba, Raúl, additional, Bilgin, Yavuz M., additional, Falces-Romero, Iker, additional, El-Ashwah, Shaimaa, additional, Emarah, Ziad, additional, Besson, Caroline, additional, Kohn, Milena, additional, Van Doesum, Jaap, additional, Ammatuna, Emanuele, additional, Marchetti, Monia, additional, Labrador, Jorge, additional, Zambrotta, Giovanni Paolo Maria, additional, Verga, Luisa, additional, Jaksic, Ozren, additional, Nucci, Marcio, additional, Piukovics, Klára, additional, Cabirta-Touzón, Alba, additional, Jiménez, Moraima, additional, Arellano, Elena, additional, Espigado, Ildefonso, additional, Blennow, Ola, additional, Nordlander, Anna, additional, Meers, Stef, additional, Vian Praet, Jens, additional, Aiello, Tommaso Francesco, additional, Garcia-Vidal, Carolina, additional, Fracchiolla, Nicola S., additional, Sciumè, Mariarita, additional, Seval, Guldane Cengiz, additional, Žák, Pavel, additional, Buquicchio, Caterina, additional, Tascini, Carlo, additional, Gräfe, Stefanie K., additional, Schönlein, Martin, additional, Adžić-VUKIČEVIĆ, Tatjana, additional, Bonuomo, Valentina, additional, Cattaneo, Chiara, additional, Nizamuddin, Summiya, additional, Čerňan, Martin, additional, Plantefeve, Gaëtan, additional, Prin, Romane, additional, Szotkovski, Tomas, additional, Collins, Graham P., additional, Dargenio, Michelina, additional, Petzer, Verena, additional, Wolf, Dominik, additional, Čolović, Natasha, additional, Prezioso, Lucia, additional, Valković, Toni, additional, Passamonti, Francesco, additional, Méndez, Gustavo-Adolfo, additional, Sili, Uluhan, additional, Vena, Antonio, additional, Bavastro, Martina, additional, Limongelli, Alessandro, additional, Duarte, Rafael F., additional, Ledoux, Marie-Pierre, additional, Cvetanoski, Milche, additional, Stojanoski, Zlate, additional, Machado, Marina, additional, Batinić, Josip, additional, Magliano, Gabriele, additional, Biernat, Monika M., additional, Pantić, Nikola, additional, Poulsen, Christian Bjørn, additional, Cuccaro, Annarosa, additional, Del Principe, Maria Ilaria, additional, Kulasekararaj, Austin, additional, Ormazabal-Vélez, Irati, additional, Busca, Alessandro, additional, Demirkan, Fatih, additional, Ijaz, Marriyam, additional, Klimko, Nikolai, additional, Stoma, Igor, additional, Khostelidi, Sofya, additional, Fernández, Noemí, additional, Omrani, Ali S., additional, Bergantim, Rui, additional, De Jonge, Nick, additional, Fouquet, Guillemette, additional, Navrátil, Milan, additional, Abu-Zeinah, Ghaith, additional, Samarkos, Michail, additional, Maertens, Johan, additional, De Ramón, Cristina, additional, Guidetti, Anna, additional, Magyari, Ferenc, additional, González-López, Tomás José, additional, Lahmer, Tobias, additional, Finizio, Olimpia, additional, Ali, Natasha, additional, Pinczés, László Imre, additional, Lavilla-Rubira, Esperanza, additional, Romano, Alessandra, additional, Merelli, Maria, additional, Delia, Mario, additional, Calbacho, Maria, additional, Meletiadis, Joseph, additional, Antić, Darko, additional, Hernández-Rivas, José-Ángel, additional, Marques De Almeida, Joyce, additional, Al-Khabori, Murtadha, additional, Hoenigl, Martin, additional, Tisi, Maria Chiara, additional, Khanna, Nina, additional, Barać, Aleksandra, additional, Eisa, Noha, additional, Di Blasi, Roberta, additional, Liévin, Raphaël, additional, Miranda-Castillo, Carolina, additional, Bahr, Nathan C., additional, Lamure, Sylvain, additional, Papa, Mario Virgilio, additional, Yahya, Ayel, additional, Aujayeb, Avinash, additional, Novák, Jan, additional, Erben, Nurettin, additional, Fernández-Galán, María, additional, Ribera-Santa Susana, José-María, additional, Rinaldi, Ikhwan, additional, Fazzi, Rita, additional, Piedimonte, Monica, additional, Duléry, Rémy, additional, Gonzaga, Yung, additional, Soto-Silva, Andrés, additional, Sapienza, Giuseppe, additional, Serris, Alexandra, additional, Drgoňa, Ľuboš, additional, Groh, Ana, additional, Serrano, Laura, additional, Gavriilaki, Eleni, additional, Tragiannidis, Athanasios, additional, Prattes, Juergen, additional, Coppola, Nicola, additional, Otašević, Vladimir, additional, Mladenović, Miloš, additional, Mitrović, Mirjana, additional, Mišković, Bojana, additional, Jindra, Pavel, additional, Zompi, Sofia, additional, Sacchi, Maria Vittoria, additional, Krekeler, Carolin, additional, Shumilov, Evgenii, additional, Infante, Maria Stefania, additional, García-Bordallo, Daniel, additional, Çolak, Gökçe Melis, additional, Cingolani, Antonella, additional, Mayer, Jiří, additional, Criscuolo, Marianna, additional, Nygaard, Marietta, additional, Hanáková, Michaela, additional, Fianchi, Luana, additional, Ráčil, Zdeněk, additional, Giordano, Antonio, additional, Quattrone, Martina, additional, Bonanni, Matteo, additional, Koehler, Philipp, additional, Rahimli, Laman, additional, Cornely, Oliver A., additional, Pagano, Livio, additional, Martín-Vallejo, Francisco Javier, additional, Zdziarski, Przemyslaw, additional, Zarrinfer, Hossein, additional, Wittig, Jana, additional, Win, Sein, additional, Wai-Man, Vivien, additional, Víšek, Benjamín, additional, Vinh, Donald C., additional, Vehreschild, Maria, additional, Varricchio, Gina, additional, Tsirigotis, Panagiotis, additional, Torres-Tienza, Ana, additional, Tanase, Alina Daniela, additional, Tafuri, Agostino, additional, Stamouli, Maria, additional, Sramek, Jiří, additional, Soussain, Carole, additional, Shirinova, Ayten, additional, Schubert, Jörg, additional, Schalk, Enrico, additional, Salehi, Mohammad Reza, additional, Saleh, Modar, additional, Rosati, Giorgio, additional, Roldán, Elisa, additional, Reizine, Florian, additional, Rêgo, Mayara, additional, Regalado-Artamendi, Isabel, additional, Popova, Marina, additional, Pinto, Fernando, additional, Philippe, Laure, additional, Orth, Hans Martin, additional, Ommen, Hans-Beier, additional, Obr, Aleš, additional, Núñez-Martín-Buitrago, Lucía, additional, Noël, Nicolas, additional, Neuhann, Julia, additional, Nadali, Gianpaolo, additional, Nacov, Julia A., additional, Munhoz Alburquerque, Ana M., additional, Mitra, Maria Enza, additional, Mikulska, Malgorzata, additional, Mellinghoff, Sibylle, additional, Mechtel, Ben, additional, Martín-González, Juan-Alberto, additional, Malak, Sandra, additional, Loureiro-Amigo, Jorge, additional, Lorenzo De La Peña, Lisset, additional, Liberti, Giulia, additional, Landau, Marianne, additional, Lacej, Ira, additional, Kolditz, Martin, additional, Kho, Chi Shan, additional, Khedr, Reham Abdelaziz, additional, Karthaus, Meinolf, additional, Karlsson, Linda Katharina, additional, Jiménez-Lorenzo, María-Josefa, additional, Izuzquiza, Macarena, additional, Hoell-Neugebauer, Baerbel, additional, Herbrecht, Raoul, additional, Heath, Christopher H., additional, Guolo, Fabio, additional, Grothe, Jan, additional, Gerasymchuk, Sergey, additional, García-Sanz, Ramón, additional, García-Poutón, Nicole, additional, Funke, Vaneuza Araújo Moreira, additional, Fung, Monica, additional, Flasshove, Charlotte, additional, Essame, Jenna, additional, Egger, Matthias, additional, Drenou, Bernard, additional, Dragonetti, Giulia, additional, Desole, Maximilian, additional, Della Pepa, Roberta, additional, Deau Fischer, Bénédicte, additional, De Kort, Elizabeth, additional, De Cabo, Erik, additional, Danion, François, additional, Daguindau, Etienne, additional, Cushion, Tania, additional, Cremer, Louise, additional, Cordini, Gregorio, additional, Ciceri, Fabio, additional, Chowdhury, Fazle Rabbi, additional, Chelysheva, Ekaterina, additional, Chauchet, Adrien, additional, Chai, Louis Yi Ann, additional, Ceesay, M. Mansour, additional, Busch, Elena, additional, Brehon, Mathias, additional, Borducchi, Davimar M.M., additional, Booth, Stephen, additional, Bologna, Serge, additional, Berg Venemyr, Caroline, additional, Bailén-Almorox, Rebeca, additional, Antoniadou, Anastasia, additional, Anastasopoulou, Amalia N., additional, and Altuntaş, Fevzi, additional

Published
2024
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18. Predicting the next pandemic: VACCELERATE ranking of the World Health Organization's Blueprint for Action to Prevent Epidemics

Author

Hart- en Vaatziekten Team A, Epi Infectieziekten Team 1, Child Health, Infection & Immunity, JC onderzoeksprogramma Infectious Diseases, MMB Medische Staf, Salmanton-García, Jon, Wipfler, Pauline, Leckler, Janina, Nauclér, Pontus, Mallon, Patrick W., Bruijning-Verhagen, Patricia C.J.L., Schmitt, Heinz Joseph, Bethe, Ullrich, Olesen, Ole F., Stewart, Fiona A., Albus, Kerstin, Cornely, Oliver A., Busch, Martin, Seifert, Ulrike, Widmer, Andreas, Nagao, Miki, Rello, Jordi, Todorova, Tatina, Cviljević, Sabina, Heath, Christopher H., Jančorienė, Ligita, Fischer, Thea Koelsen, Orth, Hans Martin, Johansen, Isik Somuncu, Doymaz, Mehmet, Tragiannidis, Athanasios, Löscher, Thomas, Xu, Jin Fu, Husa, Petr, Oteo, José Antonio, Issack, Mohammad I., Zeitlinger, Markus, Le Grand, Roger, Zdziarski, Przemysław, Demirkan, Fatih, Amador, Paloma Merino, García-Lozano, Tomás, Cao, Qing, Vázquez, Lourdes, Caeiro, Juan Pablo, Hermans, Peter, Nahrwar, Shahroch, Avsar, Korkut, Kumar, Deepak, Fernández, Norma, Mardani, Masoud, Segal, Esther, Pan, Angelo, Gkentzi, Despoina, Gioula, Georgia, Cortés, Jorge Alberto, Oliveira, Joaquim, van Damme, Pierre, Bin Mohd Zaili, Mohd Zaki, Antinori, Spinello, Zablockienė, Birutė, Papazisis, Georgios, Aneke, Chioma Inyang, Valerio, Maricela, McConkey, Samuel, Aujayeb, Avinash, Azzini, Anna Maria, Roganović, Jelena, Greve-Isdahl Mohn, Kristin, Kremsner, Peter, Gkrania-Klotsas, Effrossyni, Corzo, Dora, Khanna, Nina, Smiatacz, Tomasz, Scheithauer, Simone, Merelli, Maria, Klempa, Boris, Vrḫovac, Radovan, Ruggiero, Antonio, Chaudhary, Pankaj, Maquera-Afaray, Julio, Ekkelenkamp, Miquel, Jindra, Pavel, Pantić, Nikola, Guerra, Gemma Jiménez, Weiss, Guenter, Roohi, Behrad, Argyropoulos, Christos D., Silfverdal, Sven Aprne, van Praet, Jens, Bal, Zumrut Sahbudak, Kanj, Souha, Young, Barnaby, Pana, Zoi Dorothea, Roilides, Emmanuel, Stearns, Stephen C., Wauters, Joost, Baño, Jesús Rodríguez, Pletz, Mathias W., Travar, Maja, Kühn, Steven, Riera, Fernando, Cornely, Daniel, Laura, Vlad Jeni, Koehler, Philipp, Eley, Brian, Nair, Pravin K., Ciesek, Sandra, Olaru, Ioana Diana, Marques, Laura, Pontali, Emanuele, Naunheim, Alexandra, Lieb, Adrian, Gerhard, Markus, Farooqi, Joveria Qais, Turtle, Lance, Méndez, Gustavo Adolfo, Cox, Rebecca Jane, Goodman, Nigel, Caceca, Billie, Pemán, Javier, Dawood, Halima, Askling, Helena Hervius, Fomsgaard, Anders, Hernández, Alejandra Calderón, Staehelin, Cornelia, Liu, Chia Ying, Icardi, Giancarlo, Castagnola, Elio, Salzer, Helmut J.F., Lundgren, Jens, Javadli, Samir, Forghieri, Fabio, Hart- en Vaatziekten Team A, Epi Infectieziekten Team 1, Child Health, Infection & Immunity, JC onderzoeksprogramma Infectious Diseases, MMB Medische Staf, Salmanton-García, Jon, Wipfler, Pauline, Leckler, Janina, Nauclér, Pontus, Mallon, Patrick W., Bruijning-Verhagen, Patricia C.J.L., Schmitt, Heinz Joseph, Bethe, Ullrich, Olesen, Ole F., Stewart, Fiona A., Albus, Kerstin, Cornely, Oliver A., Busch, Martin, Seifert, Ulrike, Widmer, Andreas, Nagao, Miki, Rello, Jordi, Todorova, Tatina, Cviljević, Sabina, Heath, Christopher H., Jančorienė, Ligita, Fischer, Thea Koelsen, Orth, Hans Martin, Johansen, Isik Somuncu, Doymaz, Mehmet, Tragiannidis, Athanasios, Löscher, Thomas, Xu, Jin Fu, Husa, Petr, Oteo, José Antonio, Issack, Mohammad I., Zeitlinger, Markus, Le Grand, Roger, Zdziarski, Przemysław, Demirkan, Fatih, Amador, Paloma Merino, García-Lozano, Tomás, Cao, Qing, Vázquez, Lourdes, Caeiro, Juan Pablo, Hermans, Peter, Nahrwar, Shahroch, Avsar, Korkut, Kumar, Deepak, Fernández, Norma, Mardani, Masoud, Segal, Esther, Pan, Angelo, Gkentzi, Despoina, Gioula, Georgia, Cortés, Jorge Alberto, Oliveira, Joaquim, van Damme, Pierre, Bin Mohd Zaili, Mohd Zaki, Antinori, Spinello, Zablockienė, Birutė, Papazisis, Georgios, Aneke, Chioma Inyang, Valerio, Maricela, McConkey, Samuel, Aujayeb, Avinash, Azzini, Anna Maria, Roganović, Jelena, Greve-Isdahl Mohn, Kristin, Kremsner, Peter, Gkrania-Klotsas, Effrossyni, Corzo, Dora, Khanna, Nina, Smiatacz, Tomasz, Scheithauer, Simone, Merelli, Maria, Klempa, Boris, Vrḫovac, Radovan, Ruggiero, Antonio, Chaudhary, Pankaj, Maquera-Afaray, Julio, Ekkelenkamp, Miquel, Jindra, Pavel, Pantić, Nikola, Guerra, Gemma Jiménez, Weiss, Guenter, Roohi, Behrad, Argyropoulos, Christos D., Silfverdal, Sven Aprne, van Praet, Jens, Bal, Zumrut Sahbudak, Kanj, Souha, Young, Barnaby, Pana, Zoi Dorothea, Roilides, Emmanuel, Stearns, Stephen C., Wauters, Joost, Baño, Jesús Rodríguez, Pletz, Mathias W., Travar, Maja, Kühn, Steven, Riera, Fernando, Cornely, Daniel, Laura, Vlad Jeni, Koehler, Philipp, Eley, Brian, Nair, Pravin K., Ciesek, Sandra, Olaru, Ioana Diana, Marques, Laura, Pontali, Emanuele, Naunheim, Alexandra, Lieb, Adrian, Gerhard, Markus, Farooqi, Joveria Qais, Turtle, Lance, Méndez, Gustavo Adolfo, Cox, Rebecca Jane, Goodman, Nigel, Caceca, Billie, Pemán, Javier, Dawood, Halima, Askling, Helena Hervius, Fomsgaard, Anders, Hernández, Alejandra Calderón, Staehelin, Cornelia, Liu, Chia Ying, Icardi, Giancarlo, Castagnola, Elio, Salzer, Helmut J.F., Lundgren, Jens, Javadli, Samir, and Forghieri, Fabio

Published
2024

19. Activity of venetoclax in patients with relapsed or refractory chronic lymphocytic leukaemia: analysis of the VENICE-1 multicentre, open-label, single-arm, phase 3b trial

Author

Genetica Sectie Genoomdiagnostiek, Kater, Arnon P., Arslan, Önder, Demirkan, Fatih, Herishanu, Yair, Ferhanoglu, Burhan, Diaz, Marcos Gonzalez, Leber, Brian, Montillo, Marco, Panayiotidis, Panayiotis, Rossi, Davide, Skarbnik, Alan, Tempescul, Adrian, Turgut, Mehmet, Mellink, Clemens H., van der Kevie-Kersemaekers, Anne Marie F., Lanham, Stuart, Sale, Ben, Del Rio, Luis, Popovic, Relja, Chyla, Brenda J., Busman, Todd, Komlosi, Viktor, Wang, Xifeng, Sail, Kavita, Pena, German E., Vizkelety, Tamas, Forconi, Francesco, Genetica Sectie Genoomdiagnostiek, Kater, Arnon P., Arslan, Önder, Demirkan, Fatih, Herishanu, Yair, Ferhanoglu, Burhan, Diaz, Marcos Gonzalez, Leber, Brian, Montillo, Marco, Panayiotidis, Panayiotis, Rossi, Davide, Skarbnik, Alan, Tempescul, Adrian, Turgut, Mehmet, Mellink, Clemens H., van der Kevie-Kersemaekers, Anne Marie F., Lanham, Stuart, Sale, Ben, Del Rio, Luis, Popovic, Relja, Chyla, Brenda J., Busman, Todd, Komlosi, Viktor, Wang, Xifeng, Sail, Kavita, Pena, German E., Vizkelety, Tamas, and Forconi, Francesco

Published
2024

20. Need for ICU and outcome of critically ill patients with COVID-19 and haematological malignancies: results from the EPICOVIDEHA survey

Author

Gilead Sciences, Projekt DEAL, Espigado, Ildefonso [0000-0002-4043-6613], Lahmer, Tobias, Salmanton-García, Jon, Marchesi, Francesco, El-Ashwah, Shaimaa, Nucci, Marcio, Besson, Caroline, Itri, Federico, Jaksic, Ozren, Čolović, Natasha, Weinbergerová, Barbora, Seval, Guldane Cengiz, Adžić-Vukičević, Tatjana, Szotkowski, Tomáš, Sili, Uluhan, Dargenio, Michelina, van Praet, Jens, van Doesum, Jaap, Schönlein, Martin, Ráčil, Zdeněk, Žák, Pavel, Poulsen, Christian Bjørn, Magliano, Gabriele, Jiménez, Moraima, Bonuomo, Valentina, Piukovics, Klára, Dragonetti, Giulia, Demirkan, Fatih, Blennow, Ola, Valković, Toni, Gomes Da Silva, Maria, Maertens, Johan, Glenthøj, Andreas, Fernández, Noemí, Bergantim, Rui, Verga, Luisa, Petzer, Verena, Omrani, Ali S., Méndez, Gustavo-Adolfo, Machado, Marina, Ledoux, Marie-Pierre, Bailén, Rebeca, Duarte, Rafael F., Del Principe, Maria Ilaria, Farina, Francesca, Martín-Pérez, Sonia, Dávila-Valls, Julio, Marchetti, Monia, Bilgin, Yavuz M., Fracchiolla, Nicola S., Cattaneo, Chiara, Espigado, Ildefonso, Cordoba, Raul, Collins, Graham P., Labrador, Jorge, Falces-Romero, Iker, Prezioso, Lucia, Meers, Stef, Passamonti, Francesco, Buquicchio, Caterina, López-García, Alberto, Kulasekararaj, Austin, Ormazabal-Vélez, Irati, Cuccaro, Annarosa, Garcia-Vidal, Carolina, Busca, Alessandro, Navrátil, Milan, de Jonge, Nick, Biernat, Monika M., Guidetti, Anna, Abu-Zeinah, Ghaith, Samarkos, Michail, Anastasopoulou, Amalia, de Ramón, Cristina, González-López, Tomás José, Hoenigl, Martin, Finizio, Olimpia, Pinczés, László Imre, Ali, Natasha, Vena, Antonio, Tascini, Carlo, Stojanoski, Zlate, Merelli, Maria, Emarah, Ziad, Kohn, Milena, Barać, Aleksandra, Mladenović, Miloš, Mišković, Bojana, Ilhan, Osman, Çolak, Gökçe Melis, Čerňan, Martin, Gräfe, Stefanie K., Ammatuna, Emanuele, Hanakova, Michaela, Víšek, Benjamín, Cabirta, Alba, Nordlander, Anna, Nunes Rodrigues, Raquel, Hersby, Ditte Stampe, Zambrotta, Giovanni Paolo Maria, Wolf, Dominik, Núñez-Martín-Buitrago, Lucía, Arellano, Elena, Aiello, Tommaso Francesco, García-Sanz, Ramón, Prattes, Juergen, Egger, Matthias, Limongelli, Alessandro, Bavastro, Martina, Cvetanoski, Milche, Dibos, Miriam, Rasch, Sebastian, Rahimli, Laman, Cornely, Oliver A., Pagano, Livio, Gilead Sciences, Projekt DEAL, Espigado, Ildefonso [0000-0002-4043-6613], Lahmer, Tobias, Salmanton-García, Jon, Marchesi, Francesco, El-Ashwah, Shaimaa, Nucci, Marcio, Besson, Caroline, Itri, Federico, Jaksic, Ozren, Čolović, Natasha, Weinbergerová, Barbora, Seval, Guldane Cengiz, Adžić-Vukičević, Tatjana, Szotkowski, Tomáš, Sili, Uluhan, Dargenio, Michelina, van Praet, Jens, van Doesum, Jaap, Schönlein, Martin, Ráčil, Zdeněk, Žák, Pavel, Poulsen, Christian Bjørn, Magliano, Gabriele, Jiménez, Moraima, Bonuomo, Valentina, Piukovics, Klára, Dragonetti, Giulia, Demirkan, Fatih, Blennow, Ola, Valković, Toni, Gomes Da Silva, Maria, Maertens, Johan, Glenthøj, Andreas, Fernández, Noemí, Bergantim, Rui, Verga, Luisa, Petzer, Verena, Omrani, Ali S., Méndez, Gustavo-Adolfo, Machado, Marina, Ledoux, Marie-Pierre, Bailén, Rebeca, Duarte, Rafael F., Del Principe, Maria Ilaria, Farina, Francesca, Martín-Pérez, Sonia, Dávila-Valls, Julio, Marchetti, Monia, Bilgin, Yavuz M., Fracchiolla, Nicola S., Cattaneo, Chiara, Espigado, Ildefonso, Cordoba, Raul, Collins, Graham P., Labrador, Jorge, Falces-Romero, Iker, Prezioso, Lucia, Meers, Stef, Passamonti, Francesco, Buquicchio, Caterina, López-García, Alberto, Kulasekararaj, Austin, Ormazabal-Vélez, Irati, Cuccaro, Annarosa, Garcia-Vidal, Carolina, Busca, Alessandro, Navrátil, Milan, de Jonge, Nick, Biernat, Monika M., Guidetti, Anna, Abu-Zeinah, Ghaith, Samarkos, Michail, Anastasopoulou, Amalia, de Ramón, Cristina, González-López, Tomás José, Hoenigl, Martin, Finizio, Olimpia, Pinczés, László Imre, Ali, Natasha, Vena, Antonio, Tascini, Carlo, Stojanoski, Zlate, Merelli, Maria, Emarah, Ziad, Kohn, Milena, Barać, Aleksandra, Mladenović, Miloš, Mišković, Bojana, Ilhan, Osman, Çolak, Gökçe Melis, Čerňan, Martin, Gräfe, Stefanie K., Ammatuna, Emanuele, Hanakova, Michaela, Víšek, Benjamín, Cabirta, Alba, Nordlander, Anna, Nunes Rodrigues, Raquel, Hersby, Ditte Stampe, Zambrotta, Giovanni Paolo Maria, Wolf, Dominik, Núñez-Martín-Buitrago, Lucía, Arellano, Elena, Aiello, Tommaso Francesco, García-Sanz, Ramón, Prattes, Juergen, Egger, Matthias, Limongelli, Alessandro, Bavastro, Martina, Cvetanoski, Milche, Dibos, Miriam, Rasch, Sebastian, Rahimli, Laman, Cornely, Oliver A., and Pagano, Livio

Abstract

The risk for a severe coronavirus disease 2019 (COVID-19) with need for an intensive care unit (ICU) admission in a non-immunocompromised vaccinated population dropped from 5% at the beginning of the pandemic to at least 0.2% and is still decreasing since the omicron strain dominates the COVID-19 pandemic [1]. Beyond the risk factors identified for a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection like male sex, older age, and comorbidities such as cardiovascular disease, lung disease or obesity, patients with a history of malignancy, specifically patients with haematological malignancy, are prone to develop a complicated SARS-CoV-2 infection with need for ICU which is still associated with poorer clinical outcome [2,3,4,5,6,7,8,9,10,11,12,13,14,15]. The circumstances of a widely heterogenous population with regards to the type of haematological malignancy, extent of disease, haematological malignancy treatment history, [16,17,18] and baseline performance status are even more challenging in the environment of an ICU [19]. Although, data referring to critically ill COVID-19 patients regarding treatment strategies and outcome are widely available, data referring to critically ill patients with haematological malignancy are scarce and underreported [20]. The aim of this study is to analyze the epidemiology, risk factors and outcome of patients with haematological malignancy with need for an ICU setting using the data from the large-scale EPICOVIDEHA registry of the European Hematology Association—Scientific Working Group Infectious in Hematology (EHA-SWG) [21].

Published
2024

21. Decoding the historical tale: COVID-19 impact on haematological malignancy patients-EPICOVIDEHA insights from 2020 to 2022

Author

Arellano-Orden, Elena [0000-0003-0581-8947], Salmanton-García, Jon, Marchesi, Francesco, Farina, Francesca, Weinbergerová, Barbora, Itri, Federico, Dávila-Valls, Julio, Martín-Pérez, Sonia, Glenthøj, Andreas, Hersby, Ditte Stampe, Gomes da Silva, Maria, Nunes Rodrigues, Raquel, López-García, Alberto, Córdoba, Raúl, Bilgin, Yavuz M., Falces-Romero, Iker, El-Ashwah, Shaimaa, Emarah, Ziad, Besson, Caroline, Kohn, Milena, Van Doesum, Jaap, Ammatuna, Emanuele, Marchetti, Monia, Labrador, Jorge, Zambrotta, Giovanni Paolo Maria, Verga, Luisa, Jaksic, Ozren, Nucci, Marcio, Piukovics, Klára, Cabirta-Touzón, Alba, Jiménez, Moraima, Arellano-Orden, Elena, Espigado, Ildefonso, Blennow, Ola, Nordlander, Anna, Meers, Stef, van Praet, Jens, Aiello, Tommaso Francesco, Garcia-Vidal, Carolina, Fracchiolla, Nicola, Sciumè, Mariarita, Seval, Guldane Cengiz, Žák, Pavel, Buquicchio, Caterina, Tascini, Carlo, Gräfe, Stefanie K., Schönlein, Martin, Adžić-Vukičević, Tatjana, Bonuomo, Valentina, Cattaneo, Chiara, Nizamuddin, Summiya, Čerňan, Martin, Plantefeve, Gaëtan, Prin, Romane, Szotkovski, Tomas, Collins, Graham P., Dargenio, Michelina, Petzer, Verena, Wolf, Dominik, Čolović, Natasha, Prezioso, Lucia, Valković, Toni, Passamonti, Francesco, Méndez, Gustavo-Adolfo, Sili, Uluhan, Vena, Antonio, Bavastro, Martina, Limongelli, Alessandro, Duarte, Rafael F., Ledoux, Marie-Pierre, Cvetanoski, Milche, Stojanoski, Zlate, Machado, Marina, Batinić, Josip, Magliano, Gabriele, Biernat, Monika M., Pantić, Nikola, Poulsen, Christian Bjørn, Cuccaro, Annarosa, Del Principe, Maria Ilaria, Kulasekararaj, Austin, Ormazabal-Vélez, Irati, Busca, Alessandro, Demirkan, Fatih, Ijaz, Marriyam, Klimko, Nikolai, Stoma, Igor, Khostelidi, Sofya, Fernández, Noemí, Omrani, Ali S, Bergantim, Rui, De Jonge, Nick, Fouquet, Guillemette, Navrátil, Milan, Abu-Zeinah, Ghaith, Samarkos, Michail, Maertens, Johan, De Ramón, Cristina, Guidetti, Anna, Magyari, Ferenc, González-López, Tomás José, Lahmer, Tobias, Finizio, Olimpia, Ali, Natasha, Pinczés, László Imre, Lavilla-Rubira, Esperanza, Romano, Alessandra, Merelli, Maria, Delia, Mario, Calbacho, Maria, Meletiadis, Joseph, Antić, Darko, Hernández-Rivas, José-Ángel, Marques de Almeida, Joyce, Al-Khabori, Murtadha, Hoenigl, Martin, Tisi, Maria Chiara, Khanna, Nina, Barać, Aleksandra, Eisa, Noha, Di Blasi, Roberta, Liévin, Raphaël, Miranda-Castillo, Carolina, Bahr, Nathan C., Lamure, Sylvain, Papa, Mario Virgilio, Yahya, Ayel, Aujayeb, Avinash, Novák, Jan, Erben, Nurettin, Fernández-Galán, María, Ribera-Santa Susana, José-María, Rinaldi, Ikhwan, Fazzi, Rita, Piedimonte, Monica, Duléry, Rémy, Gonzaga, Yung, Soto-Silva, Andrés, Sapienza, Giuseppe, Serris, Alexandra, Drgoňa, Ľuboš, Groh, Ana, Serrano, Laura, Gavriilaki, Eleni, Tragiannidis, Athanasios, Prattes, Juergen, Coppola, Nicola, Otašević, Vladimir, Mladenović, Miloš, Mitrović, Mirjana, Mišković, Bojana, Jindra, Pavel, Zompi, Sofia, Sacchi, Maria Vittoria, Krekeler, Carolin, Infante, Maria Stefania, García-Bordallo, Daniel, Çolak, Gökçe Melis, Mayer, Jiří, Nygaard, Marietta, Hanáková, Michaela, Ráčil, Zdeněk, Bonanni, Matteo, Koehler, Philipp, Rahimli, Laman, Cornely, Oliver A., Pagano, Livio, Arellano-Orden, Elena [0000-0003-0581-8947], Salmanton-García, Jon, Marchesi, Francesco, Farina, Francesca, Weinbergerová, Barbora, Itri, Federico, Dávila-Valls, Julio, Martín-Pérez, Sonia, Glenthøj, Andreas, Hersby, Ditte Stampe, Gomes da Silva, Maria, Nunes Rodrigues, Raquel, López-García, Alberto, Córdoba, Raúl, Bilgin, Yavuz M., Falces-Romero, Iker, El-Ashwah, Shaimaa, Emarah, Ziad, Besson, Caroline, Kohn, Milena, Van Doesum, Jaap, Ammatuna, Emanuele, Marchetti, Monia, Labrador, Jorge, Zambrotta, Giovanni Paolo Maria, Verga, Luisa, Jaksic, Ozren, Nucci, Marcio, Piukovics, Klára, Cabirta-Touzón, Alba, Jiménez, Moraima, Arellano-Orden, Elena, Espigado, Ildefonso, Blennow, Ola, Nordlander, Anna, Meers, Stef, van Praet, Jens, Aiello, Tommaso Francesco, Garcia-Vidal, Carolina, Fracchiolla, Nicola, Sciumè, Mariarita, Seval, Guldane Cengiz, Žák, Pavel, Buquicchio, Caterina, Tascini, Carlo, Gräfe, Stefanie K., Schönlein, Martin, Adžić-Vukičević, Tatjana, Bonuomo, Valentina, Cattaneo, Chiara, Nizamuddin, Summiya, Čerňan, Martin, Plantefeve, Gaëtan, Prin, Romane, Szotkovski, Tomas, Collins, Graham P., Dargenio, Michelina, Petzer, Verena, Wolf, Dominik, Čolović, Natasha, Prezioso, Lucia, Valković, Toni, Passamonti, Francesco, Méndez, Gustavo-Adolfo, Sili, Uluhan, Vena, Antonio, Bavastro, Martina, Limongelli, Alessandro, Duarte, Rafael F., Ledoux, Marie-Pierre, Cvetanoski, Milche, Stojanoski, Zlate, Machado, Marina, Batinić, Josip, Magliano, Gabriele, Biernat, Monika M., Pantić, Nikola, Poulsen, Christian Bjørn, Cuccaro, Annarosa, Del Principe, Maria Ilaria, Kulasekararaj, Austin, Ormazabal-Vélez, Irati, Busca, Alessandro, Demirkan, Fatih, Ijaz, Marriyam, Klimko, Nikolai, Stoma, Igor, Khostelidi, Sofya, Fernández, Noemí, Omrani, Ali S, Bergantim, Rui, De Jonge, Nick, Fouquet, Guillemette, Navrátil, Milan, Abu-Zeinah, Ghaith, Samarkos, Michail, Maertens, Johan, De Ramón, Cristina, Guidetti, Anna, Magyari, Ferenc, González-López, Tomás José, Lahmer, Tobias, Finizio, Olimpia, Ali, Natasha, Pinczés, László Imre, Lavilla-Rubira, Esperanza, Romano, Alessandra, Merelli, Maria, Delia, Mario, Calbacho, Maria, Meletiadis, Joseph, Antić, Darko, Hernández-Rivas, José-Ángel, Marques de Almeida, Joyce, Al-Khabori, Murtadha, Hoenigl, Martin, Tisi, Maria Chiara, Khanna, Nina, Barać, Aleksandra, Eisa, Noha, Di Blasi, Roberta, Liévin, Raphaël, Miranda-Castillo, Carolina, Bahr, Nathan C., Lamure, Sylvain, Papa, Mario Virgilio, Yahya, Ayel, Aujayeb, Avinash, Novák, Jan, Erben, Nurettin, Fernández-Galán, María, Ribera-Santa Susana, José-María, Rinaldi, Ikhwan, Fazzi, Rita, Piedimonte, Monica, Duléry, Rémy, Gonzaga, Yung, Soto-Silva, Andrés, Sapienza, Giuseppe, Serris, Alexandra, Drgoňa, Ľuboš, Groh, Ana, Serrano, Laura, Gavriilaki, Eleni, Tragiannidis, Athanasios, Prattes, Juergen, Coppola, Nicola, Otašević, Vladimir, Mladenović, Miloš, Mitrović, Mirjana, Mišković, Bojana, Jindra, Pavel, Zompi, Sofia, Sacchi, Maria Vittoria, Krekeler, Carolin, Infante, Maria Stefania, García-Bordallo, Daniel, Çolak, Gökçe Melis, Mayer, Jiří, Nygaard, Marietta, Hanáková, Michaela, Ráčil, Zdeněk, Bonanni, Matteo, Koehler, Philipp, Rahimli, Laman, Cornely, Oliver A., and Pagano, Livio

Abstract

The COVID-19 pandemic heightened risks for individuals with hematological malignancies due to compromised immune systems, leading to more severe outcomes and increased mortality. While interventions like vaccines, targeted antivirals, and monoclonal antibodies have been effective for the general population, their benefits for these patients may not be as pronounced.

Published
2024

22. The mortality of COVID-19 in CML patients from 2020 until 2022: results from the EPICOVIDEHA survey

Author

Gilead Sciences, Espigado, Ildefonso [0000-0002-4043-6613], El-Ashwah, Shaimaa, Salmanton-García, Jon, Bilgin, Yavuz M., Itri, Federico, Žák, Pavel, Weinbergerová, Barbora, Verga, Luisa, Omrani, Ali S., Silva, Maria Gomes da, Szotkowski, Tomáš, Marchetti, Monia, Buquicchio, Caterina, Nucci, Marcio, Schönlein, Martin, Farina, Francesca, Besson, Caroline, Prezioso, Lucia, Nizamuddin, Summiya, Dávila-Valls, Julio, Martín-Pérez, Sonia, Bonuomo, Valentina, Van Doesum, Jaap, Tisi, Maria Chiara, Passamonti, Francesco, Méndez, Gustavo Adolfo, Meers, Stef, Maertens, Johan, López-García, Alberto, Glenthøj, Andreas, Bonnani, Matteo, Rinaldi, Ikhwan, Ormazabal-Vélez, Irati, Labrador, Jorge, Kulasekararaj, Austin, Espigado, Ildefonso, Demirkan, Fatih, De Jonge, Nick, Collins, Graham P., Calbacho, Maria, Blennow, Ola, Al-Khabori, Murtadha, Adžić-Vukičević, Tatjana, Arellano, Elena, Mišković, Bojana, Mladenović, Miloš, Nordlander, Anna, Ráčil, Zdeněk, Ammatuna, Emanuele, Cordoba, Raul, Hersby, Ditte Stampe, Gräfe, Stefanie, Emarah, Ziad, Hanakova, Michaela, Sacchi, Maria Vittoria, Ijaz, Marriyam, Rahimli, Laman, Nunes Rodrigues, Raquel, Zambrotta, Giovanni Paolo Maria, Marchesi, Francesco, Cornely, Oliver A., Pagano, Livio, Gilead Sciences, Espigado, Ildefonso [0000-0002-4043-6613], El-Ashwah, Shaimaa, Salmanton-García, Jon, Bilgin, Yavuz M., Itri, Federico, Žák, Pavel, Weinbergerová, Barbora, Verga, Luisa, Omrani, Ali S., Silva, Maria Gomes da, Szotkowski, Tomáš, Marchetti, Monia, Buquicchio, Caterina, Nucci, Marcio, Schönlein, Martin, Farina, Francesca, Besson, Caroline, Prezioso, Lucia, Nizamuddin, Summiya, Dávila-Valls, Julio, Martín-Pérez, Sonia, Bonuomo, Valentina, Van Doesum, Jaap, Tisi, Maria Chiara, Passamonti, Francesco, Méndez, Gustavo Adolfo, Meers, Stef, Maertens, Johan, López-García, Alberto, Glenthøj, Andreas, Bonnani, Matteo, Rinaldi, Ikhwan, Ormazabal-Vélez, Irati, Labrador, Jorge, Kulasekararaj, Austin, Espigado, Ildefonso, Demirkan, Fatih, De Jonge, Nick, Collins, Graham P., Calbacho, Maria, Blennow, Ola, Al-Khabori, Murtadha, Adžić-Vukičević, Tatjana, Arellano, Elena, Mišković, Bojana, Mladenović, Miloš, Nordlander, Anna, Ráčil, Zdeněk, Ammatuna, Emanuele, Cordoba, Raul, Hersby, Ditte Stampe, Gräfe, Stefanie, Emarah, Ziad, Hanakova, Michaela, Sacchi, Maria Vittoria, Ijaz, Marriyam, Rahimli, Laman, Nunes Rodrigues, Raquel, Zambrotta, Giovanni Paolo Maria, Marchesi, Francesco, Cornely, Oliver A., and Pagano, Livio

Abstract

Since the beginning of the COVID-19 pandemic, there has been an overall improvement in patient mortality. However, haematological malignancy patients continue to experience significant impacts from COVID-19, including high rates of hospitalization, intensive care unit (ICU) admissions, and mortality. In comparison to other haematological malignancy patients, individuals with chronic myeloid leukemia (CML) generally have better prognosis. This study, conducted using a large haematological malignancy patient database (EPICOVIDEHA), demonstrated that the majority of CML patients experienced mild infections. The decline in severe and critical infections over the years can largely be attributed to the widespread administration of vaccinations and the positive response they elicited. Notably, the mortality rate among CML patients was low and exhibited a downward trend in subsequent years. Importantly, our analysis provided confirmation of the effectiveness of vaccinations in CML patients.

Published
2024

23. Survival in multiple myeloma and SARS-COV-2 infection through the COVID-19 pandemic: Results from the EPICOVIDEHA registry

Author

Optics COMMIT, Gilead Sciences, Espigado, Ildefonso [0000-0002-4043-6613], Musto, Pellegrino, Salmanton-García, Jon, Sgherza, Nicola, Bergantim, Rui, Farina, Francesca, Glenthøj, Andreas, Cengiz Seval, Guldane, Weinbergerová, Barbora, Bonuomo, Valentina, Bilgin, Yavuz M., van Doesum, Jaap, Jaksic, Ozren, Víšek, Benjamín, Falces-Romero, Iker, Marchetti, Monia, Dávila-Valls, Julio, Martín-Pérez, Sonia, Nucci, Marcio, López-García, Alberto, Itri, Federico, Buquicchio, Caterina, Verga, Luisa, Piukovics, Klára, Navrátil, Milan, Collins, Graham P., Jiménez, Moraima, Fracchiolla, Nicola S., Labrador, Jorge, Prezioso, Lucia, Rossi, Elena, Čolović, Natasha, Meers, Stef, Kulasekararaj, Austin, Cuccaro, Annarosa, Blennow, Ola, Valković, Toni, Sili, Uluhan, Ledoux, Marie-Pierre, Batinić, Josip, Passamonti, Francesco, Machado, Marina, Duarte, Rafael F., Poulsen, Christian Bjørn, Méndez, Gustavo-Adolfo, Espigado, Ildefonso, Demirkan, Fatih, Čerňan, Martin, Cattaneo, Chiara, Petzer, Verena, Magliano, Gabriele, Garcia-Vidal, Carolina, El-Ashwah, Shaimaa, Gomes-Da-Silva, Maria, Vena, Antonio, Ormazabal-Vélez, Irati, van Praet, Jens, Dargenio, Michelina, De-Ramón, Cristina, Del Principe, Maria Ilaria, Marques-De-Almeida, Joyce, Wolf, Dominik, Szotkowski, Tomáš, Obr, Aleš, Çolak, Gökçe Melis, Nordlander, Anna, Izuzquiza, Macarena, Cabirta, Alba, Zambrotta, Giovanni Paolo Maria, Cordoba, Raul, Žák, Pavel, Ammatuna, Emanuele, Mayer, Jiří, Ilhan, Osman, García-Sanz, Ramón, Quattrone, Martina, Arellano, Elena, Nunes-Rodrigues, Raquel, Emarah, Ziad, Aiello, Tommaso Francesco, Hanakova, Michaela, Ráčil, Zdeněk, Bavastro, Martina, Limongelli, Alessandro, Rahimli, Laman, Marchesi, Francesco, Cornely, Oliver A., Pagano, Livio, Optics COMMIT, Gilead Sciences, Espigado, Ildefonso [0000-0002-4043-6613], Musto, Pellegrino, Salmanton-García, Jon, Sgherza, Nicola, Bergantim, Rui, Farina, Francesca, Glenthøj, Andreas, Cengiz Seval, Guldane, Weinbergerová, Barbora, Bonuomo, Valentina, Bilgin, Yavuz M., van Doesum, Jaap, Jaksic, Ozren, Víšek, Benjamín, Falces-Romero, Iker, Marchetti, Monia, Dávila-Valls, Julio, Martín-Pérez, Sonia, Nucci, Marcio, López-García, Alberto, Itri, Federico, Buquicchio, Caterina, Verga, Luisa, Piukovics, Klára, Navrátil, Milan, Collins, Graham P., Jiménez, Moraima, Fracchiolla, Nicola S., Labrador, Jorge, Prezioso, Lucia, Rossi, Elena, Čolović, Natasha, Meers, Stef, Kulasekararaj, Austin, Cuccaro, Annarosa, Blennow, Ola, Valković, Toni, Sili, Uluhan, Ledoux, Marie-Pierre, Batinić, Josip, Passamonti, Francesco, Machado, Marina, Duarte, Rafael F., Poulsen, Christian Bjørn, Méndez, Gustavo-Adolfo, Espigado, Ildefonso, Demirkan, Fatih, Čerňan, Martin, Cattaneo, Chiara, Petzer, Verena, Magliano, Gabriele, Garcia-Vidal, Carolina, El-Ashwah, Shaimaa, Gomes-Da-Silva, Maria, Vena, Antonio, Ormazabal-Vélez, Irati, van Praet, Jens, Dargenio, Michelina, De-Ramón, Cristina, Del Principe, Maria Ilaria, Marques-De-Almeida, Joyce, Wolf, Dominik, Szotkowski, Tomáš, Obr, Aleš, Çolak, Gökçe Melis, Nordlander, Anna, Izuzquiza, Macarena, Cabirta, Alba, Zambrotta, Giovanni Paolo Maria, Cordoba, Raul, Žák, Pavel, Ammatuna, Emanuele, Mayer, Jiří, Ilhan, Osman, García-Sanz, Ramón, Quattrone, Martina, Arellano, Elena, Nunes-Rodrigues, Raquel, Emarah, Ziad, Aiello, Tommaso Francesco, Hanakova, Michaela, Ráčil, Zdeněk, Bavastro, Martina, Limongelli, Alessandro, Rahimli, Laman, Marchesi, Francesco, Cornely, Oliver A., and Pagano, Livio

Abstract

Patients affected by multiple myeloma (MM) have an increased risk of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection and subsequent coronavirus (20)19 disease (COVID-19)-related death. The changing epidemiological and therapeutic scenarios suggest that there has been an improvement in severity and survival of COVID-19 during the different waves of the pandemic in the general population, but this has not been investigated yet in MM patients. Here we analyzed a large cohort of 1221 patients with MM and confirmed SARS-CoV-2 infection observed between February 2020, and August 2022, in the EPICOVIDEHA registry from 132 centers around the world. Median follow-up was 52 days for the entire cohort and 83 days for survivors. Three-hundred and three patients died (24%) and COVID-19 was the primary reason for death of around 89% of them. Overall survival (OS) was significantly higher in vaccinated patients with both stable and active MM versus unvaccinated, while only a trend favoring vaccinated patients was observed in subjects with responsive MM. Vaccinated patients with at least 2 doses showed a better OS than those with one or no vaccine dose. Overall, according to pandemic waves, mortality rate decreased over time from 34% to 10%. In multivariable analysis, age, renal failure, active disease, hospital, and intensive care unit admission, were independently associated with a higher number of deaths, while a neutrophil count above 0.5 × 109 /L was found to be protective. This data suggests that MM patients remain at risk of SARS-CoV-2 infection even in the vaccination era, but their clinical outcome, in terms of OS, has progressively improved throughout the different viral phases of the pandemic.

Published
2024

25. Isatuximab plus pomalidomide and low-dose dexamethasone versus pomalidomide and low-dose dexamethasone in patients with relapsed and refractory multiple myeloma (ICARIA-MM): a randomised, multicentre, open-label, phase 3 study

Author

Attal, Michel, Richardson, Paul G., Rajkumar, Vincent, San-Miguel, Jesus, Beksac, Meral, Spicka, Ivan, Leleu, Xavier, Schjesvold, Fredrik, Moreau, Philippe, Dimopoulos, Meletios A., Huang, Jeffrey Shang-Yi, Minarik, Jiri, Cavo, Michele, Prince, H. Miles, Macé, Sandrine, Corzo, Kathryn P., Campana, Frank, Le-Guennec, Solenn, Dubin, Franck, Anderson, Kenneth C., Harrison, Simon, Janowski, Wojt, Kerridge, Ian, Spencer, Andrew, Delforge, Michel, Fostier, Karel, Vlummens, Philip, Wu, Ka Lung, Leblanc, Richard, Pavic, Michel, Sebag, Michael, Hajek, Roman, Maisnar, Vladimir, Pour, Ludek, Gregersen, Henrik, Benbouker, Lotfi, Caillot, Denis, Escoffre-Barbe, Martine, Facon, Thierry, Frenzel, Laurent, Hulin, Cyrille, Karlin, Lionel, Kolb, Brigitte, Pegourie, Brigitte, Perrot, Aurore, Tiab, Mourad, Vincent, Laure, Niederwieser, Dietger, Anagnostopoulos, Achilles, Delimpasi, Sosana, Kyrtsonis, Marie-Christine, Symeonidis, Anargyros, Illes, Arpad, Mikala, Gabor, Nagy, Zsolt, Bringen, Sara, Corradini, Paolo, Fabio, Ciceri, Lemoli, Roberto, Liberati, Anna, Nozzoli, Chiara, Zambello, Renato, Iida, Shinsuke, Ikeda, Takashi, Iyama, Satoshi, Matsumoto, Morio, Shimazaki, Chihiro, Sunami, Kazutaka, Suzuki, Kenshi, Uchiyama, Michihiro, Koh, Youngil, Kim, Kihyun, Lee, Jae Hoon, Min, Chang-Ki, Blacklock, Hillary, Goodman, Hugh, Neylon, Annette, Simpson, David, Grosicki, Sebastian, Jurczyszyn, Artur, Walter-Croneck, Adam, Warzocha, Krzysztof, Araujo, Luis, Moreira, Claudia, Doronin, Vadim, Mendeleeva, Larisa, Vorobyev, Vladimir, Vranovsky, Andrej, Alegre, Adrian, Gironella, Mercedes, Gonzalez Perez, Marta Sonia, Montes, Carmen, Ocio, Enrique, Rodriguez, Paula, Hardling, Mats, Lauri, Birgitta, Wang, Ming-Chung, Yeh, Su-Peng, Arat, Mutlu, Demirkan, Fatih, Gulbas, Zafer, Besisik, Sevgi Kalayoglu, Karadogan, Ihsan, Tuglular, Tulin, Unal, Ali, Vural, Filiz, Sive, Jonathan, Streetly, Matthew, Yong, Kwee, Tache, Jason, Richardson, Paul G, Rajkumar, S Vincent, Dimopoulos, Meletios A, Prince, H Miles, Corzo, Kathryn P, and Anderson, Kenneth C

Published
2019
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26. The Turkish experience with therapeutic plasma exchange: A national survey

Author

Korkmaz, Serdal, Solmaz Medeni, Serife, Demirkan, Fatih, Kalayoglu Besisik, Sevgi, Altay Dadin, Senem, Akgun Cagliyan, Gulsum, Kabukcu Hacioglu, Sibel, Sari, Ismail, Goren Sahin, Deniz, Arat, Mutlu, Dagdas, Simten, Ozet, Gulsum, Kutlu, Nermin, Karaagac Akyol, Tulay, Ozcebe, Osman Ilhami, Uskudar Teke, Hava, Kiper Unal, Demet, Guner, Naile, Tombak, Anil, Celik, Halil, Bay, Ilker, Kiki, Ilhami, Ozgur, Gokhan, Erkurt, Mehmet Ali, Ozatli, Duzgun, Meletli, Ozgur, Demircioglu, Sinan, Demir, Cengiz, Kurtoglu, Erdal, Vural, Filiz, Tobu, Mahmut, Karakus, Abdullah, Ayyildiz, Orhan, Dal, Mehmet Sinan, Afacan Ozturk, Berna, Albayrak, Murat, Ocakci, Serkan, Bolaman, Zahit, Sonmez, Mehmet, Karakus, Volkan, Gokmen Sevindik, Omur, Berber, Ilhami, Dogu, Mehmet Hilmi, Gulturk, Emine, Ulas, Turgay, Payzin, Bahriye, Kuku, Irfan, Cagirgan, Seckin, and Altuntas, Fevzi

Published
2019
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27. Safety and activity of ibrutinib in combination with nivolumab in patients with relapsed non-Hodgkin lymphoma or chronic lymphocytic leukaemia: a phase 1/2a study

Author

Younes, Anas, Brody, Joshua, Carpio, Cecilia, Lopez-Guillermo, Armando, Ben-Yehuda, Dina, Ferhanoglu, Burhan, Nagler, Arnon, Ozcan, Muhit, Avivi, Irit, Bosch, Francesc, Caballero Barrigón, Maria Dolores, Hellmann, Andrzej, Kuss, Bryone, Ma, David D F, Demirkan, Fatih, Yağci, Münci, Horowitz, Netanel A, Marlton, Paula, Cordoba, Raul, Wrobel, Tomasz, Buglio, Daniela, Streit, Michael, Hodkinson, Brendan P, Schaffer, Michael, Alvarez, John, Ceulemans, Rob, Balasubramanian, Sriram, de Jong, Jan, Wang, Shean-Sheng, Fourneau, Nele, and Jurczak, Wojciech

Published
2019
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28. Predicting the next pandemic: VACCELERATE ranking of the World Health Organization's Blueprint for Action to Prevent Epidemics

Author

Salmanton-García, Jon, primary, Wipfler, Pauline, additional, Leckler, Janina, additional, Nauclér, Pontus, additional, Mallon, Patrick W., additional, Bruijning-Verhagen, Patricia C.J.L., additional, Schmitt, Heinz-Joseph, additional, Bethe, Ullrich, additional, Olesen, Ole F., additional, Stewart, Fiona A., additional, Albus, Kerstin, additional, Cornely, Oliver A., additional, Busch, Martin, additional, Seifert, Ulrike, additional, Widmer, Andreas, additional, Nagao, Miki, additional, Rello, Jordi, additional, Todorova, Tatina, additional, Cviljević, Sabina, additional, Heath, Christopher H., additional, Jančorienė, Ligita, additional, Fischer, Thea Koelsen, additional, Orth, Hans Martin, additional, Johansen, Isik Somuncu, additional, Doymaz, Mehmet, additional, Tragiannidis, Athanasios, additional, Löscher, Thomas, additional, Xu, Jin-Fu, additional, Husa, Petr, additional, Oteo, José Antonio, additional, Issack, Mohammad I., additional, Zeitlinger, Markus, additional, Le Grand, Roger, additional, Zdziarski, Przemysław, additional, Demirkan, Fatih, additional, Amador, Paloma Merino, additional, García-Lozano, Tomás, additional, Cao, Qing, additional, Vázquez, Lourdes, additional, Caeiro, Juan Pablo, additional, Hermans, Peter, additional, Nahrwar, Shahroch, additional, Avsar, Korkut, additional, Kumar, Deepak, additional, Fernández, Norma, additional, Mardani, Masoud, additional, Segal, Esther, additional, Pan, Angelo, additional, Gkentzi, Despoina, additional, Gioula, Georgia, additional, Cortés, Jorge Alberto, additional, Oliveira, Joaquim, additional, van Damme, Pierre, additional, Bin Mohd Zaili, Mohd Zaki, additional, Antinori, Spinello, additional, Zablockienė, Birutė, additional, Papazisis, Georgios, additional, Aneke, Chioma Inyang, additional, Valerio, Maricela, additional, McConkey, Samuel, additional, Aujayeb, Avinash, additional, Azzini, Anna Maria, additional, Roganović, Jelena, additional, Greve-Isdahl Mohn, Kristin, additional, Kremsner, Peter, additional, Gkrania-Klotsas, Effrossyni, additional, Corzo, Dora, additional, Khanna, Nina, additional, Smiatacz, Tomasz, additional, Scheithauer, Simone, additional, Merelli, Maria, additional, Klempa, Boris, additional, Vrḫovac, Radovan, additional, Ruggiero, Antonio, additional, Chaudhary, Pankaj, additional, Maquera-Afaray, Julio, additional, Ekkelenkamp, Miquel, additional, Jindra, Pavel, additional, Pantić, Nikola, additional, Guerra, Gemma Jiménez, additional, Weiss, Guenter, additional, Roohi, Behrad, additional, Argyropoulos, Christos D., additional, Silfverdal, Sven Aprne, additional, van Praet, Jens, additional, Bal, Zumrut Sahbudak, additional, Kanj, Souha, additional, Young, Barnaby, additional, Pana, Zoi Dorothea, additional, Roilides, Emmanuel, additional, Stearns, Stephen C., additional, Wauters, Joost, additional, Baño, Jesús Rodríguez, additional, Pletz, Mathias W., additional, Travar, Maja, additional, Kühn, Steven, additional, Riera, Fernando, additional, Cornely, Daniel, additional, Laura, Vlad Jeni, additional, Koehler, Philipp, additional, Eley, Brian, additional, Nair, Pravin K., additional, Ciesek, Sandra, additional, Olaru, Ioana Diana, additional, Marques, Laura, additional, Pontali, Emanuele, additional, Naunheim, Alexandra, additional, Lieb, Adrian, additional, Gerhard, Markus, additional, Farooqi, Joveria Qais, additional, Turtle, Lance, additional, Méndez, Gustavo Adolfo, additional, Cox, Rebecca Jane, additional, Goodman, Nigel, additional, Caceca, Billie, additional, Pemán, Javier, additional, Dawood, Halima, additional, Askling, Helena Hervius, additional, Fomsgaard, Anders, additional, Hernández, Alejandra Calderón, additional, Staehelin, Cornelia, additional, Liu, Chia-Ying, additional, Icardi, Giancarlo, additional, Castagnola, Elio, additional, Salzer, Helmut J.F., additional, Lundgren, Jens, additional, Javadli, Samir, additional, and Forghieri, Fabio, additional

Published
2024
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29. Ibrutinib plus obinutuzumab versus chlorambucil plus obinutuzumab in first-line treatment of chronic lymphocytic leukaemia (iLLUMINATE): a multicentre, randomised, open-label, phase 3 trial

Author

Moreno, Carol, Greil, Richard, Demirkan, Fatih, Tedeschi, Alessandra, Anz, Bertrand, Larratt, Loree, Simkovic, Martin, Samoilova, Olga, Novak, Jan, Ben-Yehuda, Dina, Strugov, Vladimir, Gill, Devinder, Gribben, John G, Hsu, Emily, Lih, Chih-Jian, Zhou, Cathy, Clow, Fong, James, Danelle F, Styles, Lori, and Flinn, Ian W

Published
2019
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30. Survival in multiple myeloma and SARS‐COV‐2 infection through the COVID‐19 pandemic: Results from the EPICOVIDEHA registry

Author

Musto, Pellegrino, primary, Salmanton‐García, Jon, additional, Sgherza, Nicola, additional, Bergantim, Rui, additional, Farina, Francesca, additional, Glenthøj, Andreas, additional, Cengiz Seval, Guldane, additional, Weinbergerová, Barbora, additional, Bonuomo, Valentina, additional, Bilgin, Yavuz M., additional, van Doesum, Jaap, additional, Jaksic, Ozren, additional, Víšek, Benjamín, additional, Falces‐Romero, Iker, additional, Marchetti, Monia, additional, Dávila‐Valls, Julio, additional, Martín‐Pérez, Sonia, additional, Nucci, Marcio, additional, López‐García, Alberto, additional, Itri, Federico, additional, Buquicchio, Caterina, additional, Verga, Luisa, additional, Piukovics, Klára, additional, Navrátil, Milan, additional, Collins, Graham P., additional, Jiménez, Moraima, additional, Fracchiolla, Nicola S., additional, Labrador, Jorge, additional, Prezioso, Lucia, additional, Rossi, Elena, additional, Čolović, Natasha, additional, Meers, Stef, additional, Kulasekararaj, Austin, additional, Cuccaro, Annarosa, additional, Blennow, Ola, additional, Valković, Toni, additional, Sili, Uluhan, additional, Ledoux, Marie‐Pierre, additional, Batinić, Josip, additional, Passamonti, Francesco, additional, Machado, Marina, additional, Duarte, Rafael F., additional, Poulsen, Christian Bjørn, additional, Méndez, Gustavo‐Adolfo, additional, Espigado, Ildefonso, additional, Demirkan, Fatih, additional, Čerňan, Martin, additional, Cattaneo, Chiara, additional, Petzer, Verena, additional, Magliano, Gabriele, additional, Garcia‐Vidal, Carolina, additional, El‐Ashwah, Shaimaa, additional, Gomes‐Da‐Silva, Maria, additional, Vena, Antonio, additional, Ormazabal‐Vélez, Irati, additional, van Praet, Jens, additional, Dargenio, Michelina, additional, De‐Ramón, Cristina, additional, Del Principe, Maria Ilaria, additional, Marques‐De‐Almeida, Joyce, additional, Wolf, Dominik, additional, Szotkowski, Tomáš, additional, Obr, Aleš, additional, Çolak, Gökçe Melis, additional, Nordlander, Anna, additional, Izuzquiza, Macarena, additional, Cabirta, Alba, additional, Zambrotta, Giovanni Paolo Maria, additional, Cordoba, Raul, additional, Žák, Pavel, additional, Ammatuna, Emanuele, additional, Mayer, Jiří, additional, Ilhan, Osman, additional, García‐Sanz, Ramón, additional, Quattrone, Martina, additional, Arellano, Elena, additional, Nunes‐Rodrigues, Raquel, additional, Emarah, Ziad, additional, Aiello, Tommaso Francesco, additional, Hanakova, Michaela, additional, Ráčil, Zdeněk, additional, Bavastro, Martina, additional, Limongelli, Alessandro, additional, Rahimli, Laman, additional, Marchesi, Francesco, additional, Cornely, Oliver A., additional, and Pagano, Livio, additional

Published
2023
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31. The mortality of COVID-19 in CML patients from 2020 until 2022: results from the EPICOVIDEHA survey

Author

El-Ashwah, Shaimaa, primary, Salmanton-García, Jon, additional, Bilgin, Yavuz M., additional, Itri, Federico, additional, Žák, Pavel, additional, Weinbergerová, Barbora, additional, Verga, Luisa, additional, Omrani, Ali S., additional, Silva, Maria Gomes da, additional, Szotkowski, Tomáš, additional, Marchetti, Monia, additional, Buquicchio, Caterina, additional, Nucci, Marcio, additional, Schönlein, Martin, additional, Farina, Francesca, additional, Besson, Caroline, additional, Prezioso, Lucia, additional, Nizamuddin, Summiya, additional, Dávila-Valls, Julio, additional, Martín-Pérez, Sonia, additional, Bonuomo, Valentina, additional, Van Doesum, Jaap, additional, Tisi, Maria Chiara, additional, Passamonti, Francesco, additional, Méndez, Gustavo-Adolfo, additional, Meers, Stef, additional, Maertens, Johan, additional, López-García, Alberto, additional, Glenthøj, Andreas, additional, Bonnani, Matteo, additional, Rinaldi, Ikhwan, additional, Ormazabal-Vélez, Irati, additional, Labrador, Jorge, additional, Kulasekararaj, Austin, additional, Espigado, Ildefonso, additional, Demirkan, Fatih, additional, De Jonge, Nick, additional, Collins, Graham P., additional, Calbacho, Maria, additional, Blennow, Ola, additional, Al-Khabori, Murtadha, additional, Adžić-Vukičević, Tatjana, additional, Arellano, Elena, additional, Mišković, Bojana, additional, Mladenović, Miloš, additional, Nordlander, Anna, additional, Ráčil, Zdeněk, additional, Ammatuna, Emanuele, additional, Cordoba, Raul, additional, Hersby, Ditte Stampe, additional, Gräfe, Stefanie, additional, Emarah, Ziad, additional, Hanakova, Michaela, additional, Sacchi, Maria Vittoria, additional, Ijaz, Marriyam, additional, Rahimli, Laman, additional, Nunes Rodrigues, Raquel, additional, Zambrotta, Giovanni Paolo Maria, additional, Marchesi, Francesco, additional, Cornely, Oliver A., additional, and Pagano, Livio, additional

Published
2023
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33. A multicenter experience of thrombotic microangiopathies in Turkey: The Turkish Hematology Research and Education Group (ThREG)-TMA01 study

Author

Tekgündüz, Emre, Yılmaz, Mehmet, Erkurt, Mehmet Ali, Kiki, Ilhami, Kaya, Ali Hakan, Kaynar, Leylagul, Alacacioglu, Inci, Cetin, Guven, Ozarslan, Ibrahim, Kuku, Irfan, Sincan, Gulden, Salim, Ozan, Namdaroglu, Sinem, Karakus, Abdullah, Karakus, Volkan, Altuntas, Fevzi, Sari, Ismail, Ozet, Gulsum, Aydogdu, Ismet, Okan, Vahap, Kaya, Emin, Yildirim, Rahsan, Yildizhan, Esra, Ozgur, Gokhan, Ozcebe, Osman Ilhami, Payzin, Bahriye, Akpinar, Seval, and Demirkan, Fatih

Published
2018
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34. Age, Successive Waves, Immunization, and Mortality in Elderly COVID-19 Haematological Patients: EPICOVIDEHA Findings

Author

ROSSI, Giuseppe, primary, SALMANTON-GARCÍA, Jon, additional, CATTANEO, Chiara, additional, MARCHESI, Francesco, additional, DÁVILA-VALLS, Julio, additional, MARTÍN-PÉREZ, Sonia, additional, ITRI, Federico, additional, LÓPEZ-GARCÍA, Alberto, additional, GLENTHØJ, Andreas, additional, SILVA, Maria GOMES DA, additional, BESSON, Caroline, additional, MARCHETTI, Monia, additional, WEINBERGEROVÁ, Barbora, additional, JAKSIC, Ozren, additional, JIMÉNEZ, Moraima, additional, BILGIN, Yavuz M., additional, DOESUM, Jaap VAN, additional, FARINA, Francesca, additional, ŽÁK, Pavel, additional, VERGA, Luisa, additional, COLLINS, Graham P., additional, BONUOMO, Valentina, additional, PRAET, Jens VAN, additional, NUCCI, Marcio, additional, MEERS, Stef, additional, ESPIGADO, Ildefonso, additional, FRACCHIOLLA, Nicola S., additional, VALKOVIĆ, Toni, additional, POULSEN, Christian Bjørn, additional, ČOLOVIĆ, Natasha, additional, DRAGONETTI, Giulia, additional, LEDOUX, Marie-Pierre, additional, TASCINI, Carlo, additional, BUQUICCHIO, Caterina, additional, BLENNOW, Ola, additional, PASSAMONTI, Francesco, additional, MACHADO, Marina, additional, LABRADOR, Jorge, additional, DUARTE, Rafael F., additional, SCHÖNLEIN, Martin, additional, PREZIOSO, Lucia, additional, FALCES-ROMERO, Iker, additional, KULASEKARARAJ, Austin, additional, GARCIA-VIDAL, Carolina, additional, FERNÁNDEZ, Noemí, additional, ABU-ZEINAH, Ghaith, additional, ORMAZABAL-VÉLEZ, Irati, additional, ADŽIĆ-VUKIČEVIĆ, Tatjana, additional, PIUKOVICS, Klára, additional, STOMA, Igor, additional, CUCCARO, Annarosa, additional, MAGLIANO, Gabriele, additional, SZOTKOWSKI, Tomáš, additional, GONZÁLEZ-LÓPEZ, Tomás-José, additional, EL-ASHWAH, Shaimaa, additional, BERGANTIM, Rui, additional, SILI, Uluhan, additional, MAERTENS, Johan, additional, DEMIRKAN, Fatih, additional, RAMÓN, Cristina DE, additional, PETZER, Verena, additional, PRINCIPE, Maria Ilaria DEL, additional, NAVRÁTIL, Milan, additional, DARGENIO, Michelina, additional, SEVAL, Guldane Cengiz, additional, SAMARKOS, Michail, additional, RÁČIL, Zdeněk, additional, PINCZÉS, László Imre, additional, LAHMER, Tobias, additional, BUSCA, Alessandro, additional, MÉNDEZ, Gustavo-Adolfo, additional, VENA, Antonio, additional, BIERNAT, Monika M., additional, MERELLI, Maria, additional, CALBACHO, Maria, additional, BARAĆ, Aleksandra, additional, BAVASTRO, Martina, additional, LIMONGELLI, Alessandro, additional, ILHAN, Osman, additional, WOLF, Dominik, additional, ÇOLAK, Gökçe Melis, additional, GARCÍA-SANZ, Ramón, additional, EMARAH, Ziad, additional, MIŠKOVIĆ, Bojana, additional, GRÄFE, Stefanie, additional, MLADENOVIĆ, Miloš, additional, AIELLO, Tommaso Francesco, additional, NÚÑEZ-MARTÍN-BUITRAGO, Lucía, additional, NORDLANDER, Anna, additional, ARELLANO, Elena, additional, ZAMBROTTA, Giovanni Paolo Maria, additional, AMMATUNA, Emanuele, additional, CABIRTA, Alba, additional, SACCHI, Maria Vittoria, additional, RODRIGUES, Raquel NUNES, additional, HERSBY, Ditte Stampe, additional, HANAKOVA, Michaela, additional, RAHIMLI, Laman, additional, CORDOBA, Raul, additional, CORNELY, Oliver A., additional, and PAGANO, Livio, additional

Published
2023
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35. S149: OTHER MALIGNANCIES IN THE HISTORY OF CLL: THE FINAL ANALYSIS OF THE INTERNATIONAL MULTICENTER STUDY CONDUCTED BY ERIC, IN HARMONY.

Author

Chatzikonstantinou, Thomas, primary, Scarfò, Lydia, additional, Karakatsoulis, Georgios, additional, Minga, Eva, additional, Chamou, Dimitra, additional, Iacoboni, Gloria, additional, Kotaskova, Jana, additional, Demosthenous, Christos, additional, Alcoceba, Miguel, additional, Al-Shemari, Salem, additional, Aurran-Schleinitz, Thérèse, additional, Bacchiarri, Francesca, additional, Bellido, Mar, additional, Bijou, Fontanet, additional, Calleja, Anne, additional, Medina, Angeles, additional, Khan, Mehreen Ali, additional, Cassin, Ramona, additional, Chatzileontiadou, Sofia, additional, Collado, Rosa, additional, Davis, Zadie, additional, Dimou, Maria, additional, Donaldson, David, additional, Santos, Gimena Dos, additional, Dreta, Barbara, additional, Efstathopoulou, Maria, additional, El-Ashwah, Shaimaa, additional, Enrico, Alicia, additional, Fresa, Alberto, additional, Galimberti, Sara, additional, Galitzia, Andrea, additional, García-Serra, Rocío, additional, Gimeno, Eva, additional, González-Gascón-Y-Marín, Isabel, additional, Gozzetti, Alessandro, additional, Guarente, Valerio, additional, Guieze, Romain, additional, Gogia, Ajay, additional, Gupta, Ritu, additional, Harrop, Sean, additional, Hatzimichael, Eleftheria, additional, Herishanu, Yair, additional, Hernández-Rivas, José-Ángel, additional, Inchiappa, Luca, additional, Jaksic, Ozren, additional, Janssen, Susanne, additional, Kalicińska, Elżbieta, additional, Kamel, Laribi, additional, Karakus, Volkan, additional, Kater, Arnon P, additional, Kho, Bonnie, additional, Kislova, Maria, additional, Konstantinou, Εliana, additional, Koren-Michowitz, Maya, additional, Kotsianidis, Ioannis, additional, Kreitman, Robert J, additional, Labrador, Jorge, additional, Lad, Deepesh, additional, Levin, Mark-David, additional, Levy, Ilana, additional, Longval, Thomas, additional, Lopez-Garcia, Alberto, additional, Marquet, Juan, additional, Maynadié, Marc, additional, Maslejova, Stanislava, additional, Mayor-Bastida, Carlota, additional, Mihaljevic, Biljana, additional, Milosevic, Ivana, additional, Miras, Fatima, additional, Moia, Riccardo, additional, Morawska, Marta, additional, Murru, Roberta, additional, Nath, Uttam Kumar, additional, Navarro-Bailón, Almudena, additional, Oliveira, Ana C., additional, Olivieri, Jacopo, additional, Oscier, David, additional, Panovska-Stavridis, Irina, additional, Papaioannou, Maria, additional, Papajík, Tomas, additional, Phumphukhieo, Punyarat, additional, Pierie, Cheyenne, additional, Puiggros, Anna, additional, Rani, Lata, additional, Reda, Gianluigi, additional, Rigolin, Gian Matteo, additional, Ronson, Aharon, additional, Ruchlemer, Rosa, additional, de Deus Santos, Marcos Daniel, additional, Schipani, Mattia, additional, Schiwitza, Annett, additional, Shen, Yandong, additional, Simkovic, Martin, additional, Smirnova, Svetlana, additional, Sameh Abdelrahman Soliman, Dina, additional, Spacek, Martin, additional, Tadmor, Tamar, additional, Tomic, Kristina, additional, Tse, Eric, additional, Vassilakopoulos, Theodoros, additional, Visentin, Andrea, additional, Vitale, Candida, additional, Tresckow, Julia von, additional, Vrachiolias, George, additional, Vukovic, Vojin, additional, Walewska, Renata, additional, Wasik-Szczepanek, Ewa, additional, Xu, Zhenshu, additional, Yagci, Munci, additional, Yañez, Lucrecia, additional, Yassin, Mohamed, additional, Zuchnicka, Jana, additional, Angelopoulou, Maria, additional, Antic, Darko, additional, Biderman, Bella, additional, Catherwood, Mark, additional, Claus, Rainer, additional, Coscia, Marta, additional, Cuneo, Antonio, additional, Demirkan, Fatih, additional, Espinet, Blanca, additional, Gaidano, Gianluca, additional, Kalashnikova, Olga, additional, Laurenti, Luca, additional, Nikitin, Eugene, additional, Pangalis, Gerassimos A., additional, Panagiotidis, Panagiotis, additional, Mulligan, Stephen, additional, Popov, Viola Maria, additional, Pospisilova, Sarka, additional, Smolej, Lukas, additional, Sportoletti, Paolo, additional, Stavroyianni, Niki, additional, Tam, Constantine, additional, Trentin, Livio, additional, Chatzidimitriou, Anastasia, additional, Bosch, Francesc, additional, Doubek, Michael, additional, Ghia, Paolo, additional, and Stamatopoulos, Kostas, additional

Published
2023
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37. Current practice of autologous hematopoietic progenitor cell mobilization in adult patients with multiple myeloma and lymphoma: The results of a survey from Turkish hematology research and education group (ThREG)

Author

Tekgündüz, Emre, Demirkan, Fatih, Vural, Filiz, Göker, Hakan, Özdoğu, Hakan, Kiki, İlhami, Aydoğdu, İsmet, Kaynar, Leylagül, Erkurt, Mehmet Ali, Çağırgan, Seçkin, Beşışık, Sevgi, Dağdaş, Simten, Koca, Ebru, Kadıköylü, Gürhan, Gündüz, Eren, Yılmaz, Mehmet, Beköz, Hüseyin, Ural, Ali Uğur, Baştürk, Abdülkadir, Arat, Mutlu, Albayrak, Murat, Öztürk, Erman, Akyol, Alev, Bolaman, Ali Zahit, Nevruz, Oral, Özkan, Hasan Atilla, Özgür, Gökhan, and Altuntaş, Fevzi

Published
2017
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38. Quality of life, sexual satisfaction, anxiety and depression status in lymphoma survivors

Author

Çetintepe, Tugba, Solmaz, Serife, Türkyılmaz, Doğuş, Aşık, Nuri, Demirkan, Fatih, Özcan, Mehmet Ali, Özsan, Güner Hayri, Ündar, Bülent, Bilgir, Oktay, Alacacıoğlu, Ahmet, and Alacacıoğlu, İnci

Subjects
General Medicine
Abstract

Objective: The progressive development of lymphoma therapies has led to an important prolongation of patient survival. We aimed to investigate anxiety, depression, sexual satisfaction and health-related quality of life status in these lymphoma survivors. We examined the effects of depression, anxiety and sexual satisfaction on the quality of life. Materials and methods: In a prospective study, the data were collected from fifty lymphoma survivors. We used six forms. These forms consist of sociodemographic features, the Beck Depression Inventory (BDI), Beck Hopelessness Scala (BHS), State-Trait Anxiety Inventory (STAI I-II), Golombock-Rust Inventory of Sexual Satisfaction (GRISS) and European Organization for Research on the treatment of Cancer Questionnaires Quality of Life (QoL) - C30 questionnaires. Results: The mean age of the patients was 50,2 ± 14,8 (20 – 75) years, and 50% of them were females. In our study, we found that 26% of the patients had high depression values above the cutoff (≥ 17 of BDI score). The mean depression score of the patients was 10,6 ± 8 (0 - 32) and the mean hopelessness score was 5,7 ± 4,5 (0 - 19). The patients whose anxiety and depression scores were high role, cognitive and emotional functioning of EORTC-QLQ-C30 was found statistically significantly low. The mean STAI-I score of the patients was 35,6 ± 11,3 (22-73) and the mean STAI-II score was 41,4 ± 10,6 (23 - 67). Statistical significance in terms of emotional and social functioning was found in the patients with high anxiety scores. When all patients were evaluated with respect to GRISS, we found high scores (> 5) for frequency, communication, vaginusmus and premature ejaculation. We compared the EORTC-QoL-C30 scores and GRISS of the patients. There was an association between emotional dysfunction with high scores of frequency (p = 0.040). Also, there was an association between low scores of role functioning with high scores of avoidance and premature ejaculation (p = 0.015, p = 0.003). However, there was a significant correlation between low scores of global QoL with high scores of avoidance, communication, and touch. There was no statistically significant difference between the anxiety and depression levels of the patient according to gender. But, some functional scales including role function (p = 0.001), social function (p = 0.001) and cognitive function (p = 0.027) were lower in female patients. Conclusion: The lymphoma survivors had high anxiety and depression scores, reduced sexual functioning and low functioning scales of QoL. There was an association between sexual dysfunction low role, emotional functioning and global QoL scores in patients.

Published
2022
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40. Non-kutanöz Periferik T-hücreli Lenfomalarda Klinik Özellikler ve Tedavi Sonuçlarına ilişkin Gerçek Yaşam Deneyimi:Türk Hematoloji Araştırma ve Eğitim Grubunun Çok Merkezli Çalışması

Author

Gündüz, Mehmet, Kayıkçı, Ömür, Büyükaşık, Yahya, Eser, Bülent, Mehtap, Özgür, Sarı, İsmail, Demirkan, Fatih, Beyan, Cengiz, Vural, Filiz, Yılmaz, Mehmet, Öztürk, Erman, Akpınar, Seval, Çetin, GÜVEN, Tekgündüz, Emre, Kelkitli, Engin, Özkan, Atilla, Doğu, Mehmet Hilmi, Yıldırım, Rahşan, Payzın, Bahriye, Tıp Fakültesi, İstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Yıldırım, Rahşan, Mehmet Hilmi Doğu / W-2255-2017, Rahşan Yıldırım / GKE-1453-2022, Rahşan Yıldırım / 23988125700, and ÇETİN, GÜVEN

Subjects
cancer patient, autologous stem cell transplantation, positron emission tomography, Survival, retrospective study, Lenfomalar, pelvis, Autologous stem cell transplantation, physical examination, computer assisted tomography, Non Cutaneous Peripheral T Cell Lymphoma, Antineoplastic Combined Chemotherapy Protocols, Disease, salvage therapy, cancer survival, antineoplastic agent, Non-Hodgkin lymphoma, thorax, progression free survival, nonhodgkin lymphoma, hematology, adult, Hematopoietic Stem Cell Transplantation, Cohort, clinical trial, Hematology, anaplastic lymphoma kinase, lymph node, Prognosis, International Prognostic Index, fluorodeoxyglucose f 18, bone marrow biopsy, female, Treatment Outcome, risk factor, anaplastic large cell lymphoma, Lymphomas, overall survival, peripheral T cell lymphoma, Up-Front, overall response rate, Otolog Kök Hücre Nakli, Guidelines, cancer prognosis, Transplantation, Autologous, Article, hematopoietic cell, remission, male, autologous hematopoietic stem cell transplantation, Humans, biopsy, liver function test, human, procedures, T-cell lymphomas, Retrospective Studies, Transplantation, autotransplantation, Non-Hodgkin Lenfoma, High-Dose Chemotherapy, Lymphoma, T-Cell, Peripheral, T-Hücreli Lenfomalar, neck, A Multicenter Study of Turkish Hematology Research and Education Group (Threg).-, Turkish journal of haematology : official journal of Turkish Society of Haematology, 2022 [Kayıkçı Ö., Mehtap Ö., Sarı İ., Demirkan F., Beyan C., Çetin G., Vural F., Yılmaz M., Öztürk E., Akpınar S., et al., -Real Life Experience Regarding Clinical Characteristics and Treatment Outcome in Non-Cutaneous Peripheral T Cell Lymphomas], human tissue, multicenter study, American Society, pathology, abdomen, transplantation
Abstract

Objective: Peripheral T-cell lymphomas (PTCLs) are an uncommon and quite heterogeneous group of disorders, representing only 10%-15% of all non-Hodgkin lymphomas. Although both molecular and clinical studies have increased in recent years, we still have little knowledge regarding real-life practice with PTCLs. In this study, we aimed to investigate the clinical characteristics and treatment outcomes of a large population-based cohort of patients presenting with systemic non-cutaneous PTCL. Materials and Methods: We conducted a multicenter retrospective analysis of 190 patients consecutively diagnosed and treated with non-cutaneous PTCLs between 2008 and 2016. Results: Considering all first-line treatment combinations, the overall response rate was 65.9% with 49.4% complete remission (n=81) and 16.5% partial response (n=27). The 5-year overall survival and eventfree survival rates were significantly different between the transplant and non-transplant groups (p, Amaç: Periferik T-hücreli lenfomalar (PTHL) nadir görülen, oldukça heterojen bir grup hastalıktır ve tüm non-Hodgkin lenfomaların sadece %10-15’ini oluşturur. Son yıllarda hem moleküler hem de klinik çalışmalar artmış olsa da PTHL’ler üzerindeki gerçek yaşam verileri hakkında hala çok az bilgiye sahibiz. Bu çalışmada, sistemik, kutanöz olmayan PTHL hastaları içeren geniş popülasyon tabanlı hasta grubunun klinik özellikleri ve tedavi sonuçlarını araştırmayı amaçladık. Gereç ve Yöntemler: 2008 ve 2016 yılları arasında kutanöz olmayan PTHL tanısı ile tedavi edilen 190 ardışık hastanın geriye dönük analizini gerçekleştirdik. Bulgular: Tüm birinci basamak tedavi kombinasyonları dikkate alındığında, genel yanıt oranı; tam remisyon (n=81) %49,4 ve kısmi yanıt (n=27) %16,5 olmak üzere %65,9 saptandı. Beş yıllık genel ve olaysız sağkalım oranları, transplant ve transplant olmayan gruplar arasında önemli ölçüde farklıydı (sırasıyla, p

Published
2022
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41. Ibrutinib combined with bendamustine and rituximab compared with placebo, bendamustine, and rituximab for previously treated chronic lymphocytic leukaemia or small lymphocytic lymphoma (HELIOS): a randomised, double-blind, phase 3 study

Author

Chanan-Khan, Asher, Cramer, Paula, Demirkan, Fatih, Fraser, Graeme, Silva, Rodrigo Santucci, Grosicki, Sebastian, Pristupa, Aleksander, Janssens, Ann, Mayer, Jiri, Bartlett, Nancy L, Dilhuydy, Marie-Sarah, Pylypenko, Halyna, Loscertales, Javier, Avigdor, Abraham, Rule, Simon, Villa, Diego, Samoilova, Olga, Panagiotidis, Panagiots, Goy, Andre, Mato, Anthony, Pavlovsky, Miguel A, Karlsson, Claes, Mahler, Michelle, Salman, Mariya, Sun, Steven, Phelps, Charles, Balasubramanian, Sriram, Howes, Angela, and Hallek, Michael

Published
2016
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42. Systemic Exposure of Rituximab Increased by Ibrutinib: Pharmacokinetic Results and Modeling Based on the HELIOS Trial

Author

Lavezzi, Silvia Maria, de Jong, Jan, Neyens, Martine, Cramer, Paula, Demirkan, Fatih, Fraser, Graeme, Bartlett, Nancy, Dilhuydy, Marie-Sarah, Loscertales, Javier, Avigdor, Abraham, Rule, Simon, Samoilova, Olga, Goy, Andre, Ganguly, Siddhartha, Salman, Mariya, Howes, Angela, Mahler, Michelle, De Nicolao, Giuseppe, and Poggesi, Italo

Published
2019
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43. COVID-19 in adult acute myeloid leukemia patients:a long-term follow-up study from the European Hematology Association survey (EPICOVIDEHA)

Author

Marchesi, Francesco, Salmanton-García, Jon, Emarah, Ziad, Piukovics, Klára, Nucci, Marcio, López-García, Alberto, Ráčil, Zdeněk, Farina, Francesca, Popova, Marina, Zompi, Sofia, Audisio, Ernesta, Ledoux, Marie Pierre, Verga, Luisa, Weinbergerová, Barbora, Szotkovski, Tomas, Da Silva, Maria Gomes, Fracchiolla, Nicola, De Jonge, Nick, Collins, Graham, Marchetti, Monia, Magliano, Gabriele, García-Vidal, Carolina, Biernat, Monika M., Van Doesum, Jaap, Machado, Marina, Demirkan, Fatih, Al-Khabori, Murtadha, Žák, Pavel, Víšek, Benjamín, Stoma, Igor, Méndez, Gustavo Adolfo, Maertens, Johan, Khanna, Nina, Espigado, Ildefonso, Dragonetti, Giulia, Fianchi, Luana, Del Principe, Maria Ilaria, Cabirta, Alba, Ormazabal-Vélez, Irati, Jaksic, Ozren, Buquicchio, Caterina, Bonuomo, Valentina, Batinić, Josip, Omrani, Ali S., Lamure, Sylvain, Finizio, Olimpia, Fernández, Noemí, Falces-Romero, Iker, Blennow, Ola, Bergantim, Rui, Ali, Natasha, Win, Sein, Van Praet, Jens, Tisi, Maria Chiara, Shirinova, Ayten, Schönlein, Martin, Prattes, Juergen, Piedimonte, Monica, Petzer, Verena, Navrátil, Milan, Kulasekararaj, Austin, Jindra, Pavel, Sramek, Jiří, Glenthøj, Andreas, Fazzi, Rita, De Ramón-Sánchez, Cristina, Cattaneo, Chiara, Calbacho, Maria, Bahr, Nathan C., El-Ashwah, Shaimaa, Cordoba, Raul, Hanakova, Michaela, Zambrotta, Giovanni Paolo Maria, Zambrotta, Giovanni, Sciumè, Mariarita, Booth, Stephen, Rodrigues, Raquel Nunes, Sacchi, Maria Vittoria, García-Poutón, Nicole, Martín-González, Juan Alberto, Khostelidi, Sofya, Gräfe, Stefanie, Rahimli, Laman, Ammatuna, Emanuele, Busca, Alessandro, Corradini, Paolo, Hoenigl, Martin, Klimko, Nikolai, Koehler, Philipp, Pagliuca, Antonio, Passamonti, Francesco, Cornely, Oliver A., Pagano, Livio, Marchesi, Francesco, Salmanton-García, Jon, Emarah, Ziad, Piukovics, Klára, Nucci, Marcio, López-García, Alberto, Ráčil, Zdeněk, Farina, Francesca, Popova, Marina, Zompi, Sofia, Audisio, Ernesta, Ledoux, Marie Pierre, Verga, Luisa, Weinbergerová, Barbora, Szotkovski, Tomas, Da Silva, Maria Gomes, Fracchiolla, Nicola, De Jonge, Nick, Collins, Graham, Marchetti, Monia, Magliano, Gabriele, García-Vidal, Carolina, Biernat, Monika M., Van Doesum, Jaap, Machado, Marina, Demirkan, Fatih, Al-Khabori, Murtadha, Žák, Pavel, Víšek, Benjamín, Stoma, Igor, Méndez, Gustavo Adolfo, Maertens, Johan, Khanna, Nina, Espigado, Ildefonso, Dragonetti, Giulia, Fianchi, Luana, Del Principe, Maria Ilaria, Cabirta, Alba, Ormazabal-Vélez, Irati, Jaksic, Ozren, Buquicchio, Caterina, Bonuomo, Valentina, Batinić, Josip, Omrani, Ali S., Lamure, Sylvain, Finizio, Olimpia, Fernández, Noemí, Falces-Romero, Iker, Blennow, Ola, Bergantim, Rui, Ali, Natasha, Win, Sein, Van Praet, Jens, Tisi, Maria Chiara, Shirinova, Ayten, Schönlein, Martin, Prattes, Juergen, Piedimonte, Monica, Petzer, Verena, Navrátil, Milan, Kulasekararaj, Austin, Jindra, Pavel, Sramek, Jiří, Glenthøj, Andreas, Fazzi, Rita, De Ramón-Sánchez, Cristina, Cattaneo, Chiara, Calbacho, Maria, Bahr, Nathan C., El-Ashwah, Shaimaa, Cordoba, Raul, Hanakova, Michaela, Zambrotta, Giovanni Paolo Maria, Zambrotta, Giovanni, Sciumè, Mariarita, Booth, Stephen, Rodrigues, Raquel Nunes, Sacchi, Maria Vittoria, García-Poutón, Nicole, Martín-González, Juan Alberto, Khostelidi, Sofya, Gräfe, Stefanie, Rahimli, Laman, Ammatuna, Emanuele, Busca, Alessandro, Corradini, Paolo, Hoenigl, Martin, Klimko, Nikolai, Koehler, Philipp, Pagliuca, Antonio, Passamonti, Francesco, Cornely, Oliver A., and Pagano, Livio

Abstract

Patients with acute myeloid leukemia (AML) are at high risk of dying from coronavirus disease 2019 (COVID-19). The optimal management of AML patients with COVID-19 has not been established. Our multicenter study included 388 adult AML patients diagnosed with COVID-19 between February 2020 and October 2021. The vast majority were receiving or had received AML treatment in the preceding 3 months. COVID-19 was severe in 41.2% and critical in 21.1% of cases. The chemotherapeutic schedule was modified in 174 patients (44.8%), delayed in 68 and permanently discontinued in 106. After a median follow-up of 325 days, 180 patients (46.4%) had died; death was attributed to COVID-19 (43.3%), AML (26.1%) or to a combination of both (26.7%), whereas in 3.9% of cases the reason was unknown. Active disease, older age, and treatment discontinuation were associated with death, whereas AML treatment delay was protective. Seventy-nine patients had a simultaneous AML and COVID-19 diagnosis, with better survival when AML treatment could be delayed (80%; P<0.001). Overall survival in patients with a diagnosis of COVID-19 between January 2020 and August 2020 was significantly lower than that in patients diagnosed between September 2020 and February 2021 and between March 2021 and September 2021 (39.8% vs. 60% vs. 61.9%, respectively; P=0.006). COVID-19 in AML patients was associated with a high mortality rate and modifications of therapeutic algorithms. The best approach to improve survival was to delay AML treatment, whenever possible.

Published
2023

44. Outcomes of SARS-CoV-2 infection in Ph-neg chronic myeloproliferative neoplasms: results from the EPICOVIDEHA registry

Author

Marchetti, Monia, Salmanton-García, Jon, El-Ashwah, Shaimaa, Verga, Luisa, Itri, Federico, Ráčil, Zdeněk, Dávila-Valls, Julio, Martín-Pérez, Sonia, Van Doesum, Jaap, Passamonti, Francesco, Abu-Zeinah, Ghaith, Farina, Francesca, López-García, Alberto, Dragonetti, Giulia, Cattaneo, Chiara, Gomes Da Silva, Maria, Bilgin, Yavuz M, Žák, Pavel, Petzer, Verena, Glenthøj, Andrea, Espigado, Ildefonso, Buquicchio, Caterina, Bonuomo, Valentina, Prezioso, Lucia, Meers, Stef, Duarte, Rafael, Bergantim, Rui, Jaksic, Ozren, Čolović, Natasha, Blennow, Ola, Cernan, Martin, Schönlein, Martin, Samarkos, Michail, Mitra, Maria Enza, Magliano, Gabriele, Maertens, Johan, Ledoux, Marie-Pierre, Jiménez, Moraima, Demirkan, Fatih, Collins, Graham P, Cabirta, Alba, Gräfe, Stefanie K, Nordlander, Anna, Wolf, Dominik, Arellano, Elena, Cordoba, Raul, Hanakova, Michaela, Zambrotta, Giovanni Paolo Maria, Nunes Rodrigues, Raquel, Limberti, Giulia, Marchesi, Francesco, Cornely, Oliver A, Pagano, Livio, Pagano, Livio (ORCID:0000-0001-8287-928X), Marchetti, Monia, Salmanton-García, Jon, El-Ashwah, Shaimaa, Verga, Luisa, Itri, Federico, Ráčil, Zdeněk, Dávila-Valls, Julio, Martín-Pérez, Sonia, Van Doesum, Jaap, Passamonti, Francesco, Abu-Zeinah, Ghaith, Farina, Francesca, López-García, Alberto, Dragonetti, Giulia, Cattaneo, Chiara, Gomes Da Silva, Maria, Bilgin, Yavuz M, Žák, Pavel, Petzer, Verena, Glenthøj, Andrea, Espigado, Ildefonso, Buquicchio, Caterina, Bonuomo, Valentina, Prezioso, Lucia, Meers, Stef, Duarte, Rafael, Bergantim, Rui, Jaksic, Ozren, Čolović, Natasha, Blennow, Ola, Cernan, Martin, Schönlein, Martin, Samarkos, Michail, Mitra, Maria Enza, Magliano, Gabriele, Maertens, Johan, Ledoux, Marie-Pierre, Jiménez, Moraima, Demirkan, Fatih, Collins, Graham P, Cabirta, Alba, Gräfe, Stefanie K, Nordlander, Anna, Wolf, Dominik, Arellano, Elena, Cordoba, Raul, Hanakova, Michaela, Zambrotta, Giovanni Paolo Maria, Nunes Rodrigues, Raquel, Limberti, Giulia, Marchesi, Francesco, Cornely, Oliver A, Pagano, Livio, and Pagano, Livio (ORCID:0000-0001-8287-928X)

Abstract

Background:Patients with Philadelphia-negative chronic myeloproliferative neoplasms (MPN) typically incur high rates of infections and both drugs and comorbidities may modulate infection risk. Objectives:The present study aims to assess the effect of immunosuppressive agents on clinical outcomes of MPN patients affected by the coronavirus disease 2019 (COVID-19). Design:This is an observational study. Methods:We specifically searched and analyzed MPN patients collected by EPICOVIDEHA online registry, which includes individuals with hematological malignancies diagnosed with COVID-19 since February 2020. Results:Overall, 398 patients with MPN were observed for a median of 76 days [interquartile range (IQR): 19-197] after detection of SARS-CoV2 infection. Median age was 69 years (IQR: 58-77) and 183 individuals (46%) had myelofibrosis (MF). Overall, 121 patients (30%) of the whole cohort received immunosuppressive therapies including steroids, immunomodulatory drugs, or JAK inhibitors. Hospitalization and consecutive admission to intensive care unit was required in 216 (54%) and 53 patients (13%), respectively. Risk factors for hospital admission were identified by multivariable logistic regression and include exposure to immunosuppressive therapies [odds ratio (OR): 2.186; 95% confidence interval (CI): 1.357-3.519], age > 70 years, and comorbidities. The fatality rate was 22% overall and the risk of death was independently increased by age > 70 years [hazard ratio (HR): 2.191; 95% CI: 1.363-3.521], previous comorbidities, and exposure to immunosuppressive therapies before the infection (HR: 2.143; 95% CI: 1.363-3.521). Conclusion:COVID-19 infection led to a particularly dismal outcome in MPN patients receiving immunosuppressive agents or reporting multiple comorbidities. Therefore, specific preventive strategies need to be tailored for such individuals. Plain language summaryEPICOVIDEHA registry reports inferior outcomes of COVID-19 in patients with Philadelphia

Published
2023

45. COVID-19 in adult acute myeloid leukemia patients: a long-term follow-up study from the European Hematology Association survey (EPICOVIDEHA)

Author

Marchesi, Francesco, Salmanton-García, Jon, Emarah, Ziad, Piukovics, Klára, Nucci, Marcio, López-García, Alberto, Ráčil, Zdeněk, Farina, Francesca, Popova, Marina, Zompi, Sofia, Audisio, Ernesta, Ledoux, Marie-Pierre, Verga, Luisa, Weinbergerová, Barbora, Szotkovski, Toma, Da Silva, Maria Gome, Fracchiolla, Nicola, De Jonge, Nick, Collins, Graham, Marchetti, Monia, Magliano, Gabriele, García-Vidal, Carolina, Biernat, Monika M, Van Doesum, Jaap, Machado, Marina, Demirkan, Fatih, Al-Khabori, Murtadha, Žák, Pavel, Víšek, Benjamín, Stoma, Igor, Méndez, Gustavo-Adolfo, Maertens, Johan, Khanna, Nina, Espigado, Ildefonso, Dragonetti, Giulia, Fianchi, Luana, Del Principe, Maria Ilaria, Cabirta, Alba, Ormazabal-Vélez, Irati, Jaksic, Ozren, Buquicchio, Caterina, Bonuomo, Valentina, Batinić, Josip, Omrani, Ali S, Lamure, Sylvain, Finizio, Olimpia, Fernández, Noemí, Falces-Romero, Iker, Blennow, Ola, Bergantim, Rui, Ali, Natasha, Win, Sein, Van Praet, Jen, Tisi, Maria Chiara, Shirinova, Ayten, Schönlein, Martin, Prattes, Juergen, Piedimonte, Monica, Petzer, Verena, Navrátil, Milan, Kulasekararaj, Austin, Jindra, Pavel, Sramek, Jiří, Glenthøj, Andrea, Fazzi, Rita, De Ramón-Sánchez, Cristina, Cattaneo, Chiara, Calbacho, Maria, Bahr, Nathan C, El-Ashwah, Shaimaa, Cordoba, Raul, Hanakova, Michaela, Zambrotta, Giovanni, Sciumè, Mariarita, Booth, Stephen, Rodrigues, Raquel Nune, Sacchi, Maria Vittoria, García-Poutón, Nicole, Martín-González, Juan-Alberto, Khostelidi, Sofya, Gräfe, Stefanie, Rahimli, Laman, Ammatuna, Emanuele, Busca, Alessandro, Corradini, Paolo, Hoenigl, Martin, Klimko, Nikolai, Koehler, Philipp, Pagliuca, Antonio, Passamonti, Francesco, Cornely, Oliver A, Pagano, Livio, Pagano, Livio (ORCID:0000-0001-8287-928X), Marchesi, Francesco, Salmanton-García, Jon, Emarah, Ziad, Piukovics, Klára, Nucci, Marcio, López-García, Alberto, Ráčil, Zdeněk, Farina, Francesca, Popova, Marina, Zompi, Sofia, Audisio, Ernesta, Ledoux, Marie-Pierre, Verga, Luisa, Weinbergerová, Barbora, Szotkovski, Toma, Da Silva, Maria Gome, Fracchiolla, Nicola, De Jonge, Nick, Collins, Graham, Marchetti, Monia, Magliano, Gabriele, García-Vidal, Carolina, Biernat, Monika M, Van Doesum, Jaap, Machado, Marina, Demirkan, Fatih, Al-Khabori, Murtadha, Žák, Pavel, Víšek, Benjamín, Stoma, Igor, Méndez, Gustavo-Adolfo, Maertens, Johan, Khanna, Nina, Espigado, Ildefonso, Dragonetti, Giulia, Fianchi, Luana, Del Principe, Maria Ilaria, Cabirta, Alba, Ormazabal-Vélez, Irati, Jaksic, Ozren, Buquicchio, Caterina, Bonuomo, Valentina, Batinić, Josip, Omrani, Ali S, Lamure, Sylvain, Finizio, Olimpia, Fernández, Noemí, Falces-Romero, Iker, Blennow, Ola, Bergantim, Rui, Ali, Natasha, Win, Sein, Van Praet, Jen, Tisi, Maria Chiara, Shirinova, Ayten, Schönlein, Martin, Prattes, Juergen, Piedimonte, Monica, Petzer, Verena, Navrátil, Milan, Kulasekararaj, Austin, Jindra, Pavel, Sramek, Jiří, Glenthøj, Andrea, Fazzi, Rita, De Ramón-Sánchez, Cristina, Cattaneo, Chiara, Calbacho, Maria, Bahr, Nathan C, El-Ashwah, Shaimaa, Cordoba, Raul, Hanakova, Michaela, Zambrotta, Giovanni, Sciumè, Mariarita, Booth, Stephen, Rodrigues, Raquel Nune, Sacchi, Maria Vittoria, García-Poutón, Nicole, Martín-González, Juan-Alberto, Khostelidi, Sofya, Gräfe, Stefanie, Rahimli, Laman, Ammatuna, Emanuele, Busca, Alessandro, Corradini, Paolo, Hoenigl, Martin, Klimko, Nikolai, Koehler, Philipp, Pagliuca, Antonio, Passamonti, Francesco, Cornely, Oliver A, Pagano, Livio, and Pagano, Livio (ORCID:0000-0001-8287-928X)

Abstract

Patients with acute myeloid leukemia (AML) are at high risk of dying from coronavirus disease 2019 (COVID-19). The optimal management of AML patients with COVID-19 has not been established. Our multicenter study included 388 adult AML patients diagnosed with COVID-19 between February 2020 and October 2021. The vast majority were receiving or had received AML treatment in the preceding 3 months. COVID-19 was severe in 41.2% and critical in 21.1% of cases. The chemotherapeutic schedule was modified in 174 patients (44.8%), delayed in 68 and permanently discontinued in 106. After a median follow-up of 325 days, 180 patients (46.4%) had died; death was attributed to COVID-19 (43.3%), AML (26.1%) or to a combination of both (26.7%), whereas in 3.9% of cases the reason was unknown. Active disease, older age, and treatment discontinuation were associated with death, whereas AML treatment delay was protective. Seventy-nine patients had a simultaneous AML and COVID-19 diagnosis, with better survival when AML treatment could be delayed (80%; P<0.001). Overall survival in patients with a diagnosis of COVID-19 between January 2020 and August 2020 was significantly lower than that in patients diagnosed between September 2020 and February 2021 and between March 2021 and September 2021 (39.8% vs. 60% vs. 61.9%, respectively; P=0.006). COVID-19 in AML patients was associated with a high mortality rate and modifications of therapeutic algorithms. The best approach to improve survival was to delay AML treatment, whenever possible.

Published
2023

46. COVID-19 in adult acute myeloid leukemia patients: a long-term followup study from the European Hematology Association survey (EPICOVIDEHA)

Author

Gilead Sciences, Marchesi, Francesco, Salmanton-García, Jon, Emarah, Ziad, Piukovics, Klára, Nucci, Marcio, López-García, Alberto, Ráčil, Zdeněk, Farina, Francesca, Popova, Marina, Zompi, Sofia, Audisio, Ernesta, Ledoux, Marie-Pierre, Verga, Luisa, Weinbergerová, Barbora, Szotkovski, Tomas, Gomes-Silva, Maria, Fracchiolla, Nicola S., Jonge, Nick de, Collins, Graham P., Marchetti, Monia, Magliano, Gabriel, García-Vidal, Carolina, Biernat, Monika, Doesum, Jaap van, Machado, Marina, Demirkan, Fatih, Al-Khabori, Murtadha, Žák, Pavel, Víšek, Benjamin, Stoma, Igor, Méndez, Gustavo-Adolfo, Maertens, Johan, Khanna, Nina, Espigado, Ildefonso, Dragonetti, Giulia, Fianchi, Luana, Príncipe, María Ilaria del, Cabirta, Alba, Ormazabal-Vélez, Irati, Jakšić, Ozren, Buquicchio, Caterina, Bonuomo, Valentina, Batinić, Josip, Omrani, Ali S., Lamure, Sylvain, Finizio, Olimpia, Fernández, Noemí, Falces-Romero, Iker, Blennow, Ola, Bergantim, Rui, Ali, Natasha, Win, Sein, Praet, Jens van, Tisi, Maria Chiara, Shirinova, Ayten, Schönlein, Martin, Prattes, Juergen, Piedimonte, Monica, Petzer, Verena, Navrátil, Milan, Kulasekararaj, Austin G., Jindra, Pavel, Sramek, Jiří, Glenthøj, Andrea, Fazzi, Rita, Ramón, Cristina de, Cattaneo, Chiara, Calbacho, María, Bahr, Nathan C., El-Ashwah, Shaimaa, Córdoba, Raúl, Hanakova, Michaela, Zambrotta, Giovanni, Sciumè, Mariarita, Booth, Stephen, Nunes-Rodrigues, Raquel, Sacchi, Maria Vittoria, García-Poutón, Nicole, Martín-González, Juan-Alberto, Khostelidi, Sofya, Gräfe, Stefanie, Rahimli, Laman, Ammatuna, Emanuele, Busca, Alessandro, Corradini, Paolo, Hoenigl, Martin, Klimko, Nikolay, Koehler, Philipp, Pagliuca, Antonio, Passamonti, Francesco, Cornely, Oliver A., Pagano, Livio, Gilead Sciences, Marchesi, Francesco, Salmanton-García, Jon, Emarah, Ziad, Piukovics, Klára, Nucci, Marcio, López-García, Alberto, Ráčil, Zdeněk, Farina, Francesca, Popova, Marina, Zompi, Sofia, Audisio, Ernesta, Ledoux, Marie-Pierre, Verga, Luisa, Weinbergerová, Barbora, Szotkovski, Tomas, Gomes-Silva, Maria, Fracchiolla, Nicola S., Jonge, Nick de, Collins, Graham P., Marchetti, Monia, Magliano, Gabriel, García-Vidal, Carolina, Biernat, Monika, Doesum, Jaap van, Machado, Marina, Demirkan, Fatih, Al-Khabori, Murtadha, Žák, Pavel, Víšek, Benjamin, Stoma, Igor, Méndez, Gustavo-Adolfo, Maertens, Johan, Khanna, Nina, Espigado, Ildefonso, Dragonetti, Giulia, Fianchi, Luana, Príncipe, María Ilaria del, Cabirta, Alba, Ormazabal-Vélez, Irati, Jakšić, Ozren, Buquicchio, Caterina, Bonuomo, Valentina, Batinić, Josip, Omrani, Ali S., Lamure, Sylvain, Finizio, Olimpia, Fernández, Noemí, Falces-Romero, Iker, Blennow, Ola, Bergantim, Rui, Ali, Natasha, Win, Sein, Praet, Jens van, Tisi, Maria Chiara, Shirinova, Ayten, Schönlein, Martin, Prattes, Juergen, Piedimonte, Monica, Petzer, Verena, Navrátil, Milan, Kulasekararaj, Austin G., Jindra, Pavel, Sramek, Jiří, Glenthøj, Andrea, Fazzi, Rita, Ramón, Cristina de, Cattaneo, Chiara, Calbacho, María, Bahr, Nathan C., El-Ashwah, Shaimaa, Córdoba, Raúl, Hanakova, Michaela, Zambrotta, Giovanni, Sciumè, Mariarita, Booth, Stephen, Nunes-Rodrigues, Raquel, Sacchi, Maria Vittoria, García-Poutón, Nicole, Martín-González, Juan-Alberto, Khostelidi, Sofya, Gräfe, Stefanie, Rahimli, Laman, Ammatuna, Emanuele, Busca, Alessandro, Corradini, Paolo, Hoenigl, Martin, Klimko, Nikolay, Koehler, Philipp, Pagliuca, Antonio, Passamonti, Francesco, Cornely, Oliver A., and Pagano, Livio

Abstract

Patients with acute myeloid leukemia (AML) are at high risk of mortality from coronavirus disease 2019 (COVID-19). The optimal management of AML patients with COVID-19 has not been established. Our multicenter study included 388 adult AML patients with COVID-19 diagnosis between February 2020 and October 2021. The vast majority were receiving or had received AML treatment in the prior 3 months. COVID-19 was severe in 41.2% and critical in 21.1% of cases. The chemotherapeutic schedule was modified in 174 patients (44.8%), delayed in 68 and permanently discontinued in 106. After a median follow-up of 325 days, 180 patients (46.4%) had died; death was attributed to COVID-19 (43.3%), AML (26.1%) or to a combination of both (26.7%), whereas in 3.9% of cases the reason was unknown. Active disease, older age, and treatment discontinuation were associated with death, whereas AML treatment delay was protective. Seventy-nine patients had a simultaneous AML and COVID-19 diagnosis, with an improved survival when AML treatment could be delayed (80%; p<0.001). Overall survival in patients with COVID-19 diagnosis between January 2020 and August 2020 was significantly lower than those who were diagnosed between September 2020 and February 2021 and between March 2021 and September 2021 (39.8% vs 60% vs 61.9%, respectively; p=0.006). COVID-19 in AML patients was associated with a high mortality rate and modifications of therapeutic algorithms. The best approach to improve survival was to delay AML treatment, whenever possible.

Published
2023

47. Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients: EPICOVIDEHA findings

Author

Gilead Sciences, Rossi, Giuseppe, Salmanton-García, Jon, Cattaneo, Chiara, Marchesi, Francesco, Dávila-Valls, Julio, Martín-Pérez, Sonia, Itri, Federico, López-García, Alberto, Glenthøj, Andreas, Silva, Maria Gomes da, Besson, Caroline, Marchetti, Monia, Weinbergerová, Barbora, Jaksic, Ozren, Jiménez, Moraima, Bilgin, Yavuz M., Doesum, Jaap van, Farina, Francesca, Žák, Pavel, Verga, Luisa, Collins, Graham P., Bonuomo, Valentina, Praet, Jens van, Nucci, Marcio, Meers, Stef, Espigado, Ildefonso, Fracchiolla, Nicola S., Valković, Toni, Poulsen, Christian Bjørn, Čolović, Natasha, Dragonetti, Giulia, Ledoux, Marie-Pierre, Tascini, Carlo, Buquicchio, Caterina, Blennow, Ola, Passamonti, Francesco, Machado, Marina, Labrador, Jorge, Duarte, Rafael F., Schönlein, Martin, Prezioso, Lucia, Falces-Romero, Iker, Kulasekararaj, Austin, García-Vidal, Carolina, Fernández, Noemí, Abu-Zeinah, Ghaith, Ormazabal-Vélez, Irati, Adžić-Vukičević, Tatjana, Piukovics, Klára, Stoma, Igor, Cuccaro, Annarosa, Magliano, Gabriele, Szotkowski, Tomáš, González-López, Tomás José, El-Ashwah, Shaimaa, Bergantim, Rui, Sili, Uluhan, Maertens, Johan, Demirkan, Fatih, Ramón, Cristina de, Petzer, Verena, Príncipe, María Ilaria del, Navrátil, Milan, Dargenio, Michelina, Cengiz Seval, Guldane, Samarkos, Michail, Ráčil, Zdeněk, Pinczés, László Imre, Lahmer, Tobias, Busca, Alessandro, Méndez, Gustavo-Adolfo, Vena, Antonio, Biernat, Monika M., Merelli, Maria, Calbacho, Maria, Barać, Aleksandra, Bavastro, Martina, Limongelli, Alessandro, Ilhan, Osman, Wolf, Dominik, Çolak, Gökçe Melis, García-Sanz, Ramón, Emarah, Ziad, Mišković, Bojana, Gräfe, Stefanie, Mladenović, Miloš, Aiello, Tommaso Francesco, Núñez-Martín-Buitrago, Lucía, Nordlander, Anna, Arellano-Orden, Elena, Zambrotta, Giovanni Paolo Maria, Ammatuna, Emanuele, Cabirta, Alba, Sacchi, Maria Vittoria, Nunes-Rodrigues, Raquel, Hersby, Ditte Stampe, Hanakova, Michaela, Rahimli, Laman, Córdoba, Raúl, Cornely, Oliver A., Pagano, Livio, Collaborators, Gilead Sciences, Rossi, Giuseppe, Salmanton-García, Jon, Cattaneo, Chiara, Marchesi, Francesco, Dávila-Valls, Julio, Martín-Pérez, Sonia, Itri, Federico, López-García, Alberto, Glenthøj, Andreas, Silva, Maria Gomes da, Besson, Caroline, Marchetti, Monia, Weinbergerová, Barbora, Jaksic, Ozren, Jiménez, Moraima, Bilgin, Yavuz M., Doesum, Jaap van, Farina, Francesca, Žák, Pavel, Verga, Luisa, Collins, Graham P., Bonuomo, Valentina, Praet, Jens van, Nucci, Marcio, Meers, Stef, Espigado, Ildefonso, Fracchiolla, Nicola S., Valković, Toni, Poulsen, Christian Bjørn, Čolović, Natasha, Dragonetti, Giulia, Ledoux, Marie-Pierre, Tascini, Carlo, Buquicchio, Caterina, Blennow, Ola, Passamonti, Francesco, Machado, Marina, Labrador, Jorge, Duarte, Rafael F., Schönlein, Martin, Prezioso, Lucia, Falces-Romero, Iker, Kulasekararaj, Austin, García-Vidal, Carolina, Fernández, Noemí, Abu-Zeinah, Ghaith, Ormazabal-Vélez, Irati, Adžić-Vukičević, Tatjana, Piukovics, Klára, Stoma, Igor, Cuccaro, Annarosa, Magliano, Gabriele, Szotkowski, Tomáš, González-López, Tomás José, El-Ashwah, Shaimaa, Bergantim, Rui, Sili, Uluhan, Maertens, Johan, Demirkan, Fatih, Ramón, Cristina de, Petzer, Verena, Príncipe, María Ilaria del, Navrátil, Milan, Dargenio, Michelina, Cengiz Seval, Guldane, Samarkos, Michail, Ráčil, Zdeněk, Pinczés, László Imre, Lahmer, Tobias, Busca, Alessandro, Méndez, Gustavo-Adolfo, Vena, Antonio, Biernat, Monika M., Merelli, Maria, Calbacho, Maria, Barać, Aleksandra, Bavastro, Martina, Limongelli, Alessandro, Ilhan, Osman, Wolf, Dominik, Çolak, Gökçe Melis, García-Sanz, Ramón, Emarah, Ziad, Mišković, Bojana, Gräfe, Stefanie, Mladenović, Miloš, Aiello, Tommaso Francesco, Núñez-Martín-Buitrago, Lucía, Nordlander, Anna, Arellano-Orden, Elena, Zambrotta, Giovanni Paolo Maria, Ammatuna, Emanuele, Cabirta, Alba, Sacchi, Maria Vittoria, Nunes-Rodrigues, Raquel, Hersby, Ditte Stampe, Hanakova, Michaela, Rahimli, Laman, Córdoba, Raúl, Cornely, Oliver A., Pagano, Livio, and Collaborators

Abstract

[Objectives] Elderly patients with hematologic malignancies face the highest risk of severe COVID-19 outcomes. The infection's impact on different age groups remains unstudied in detail., [Methods] We analyzed elderly patients (age groups: 65-70, 71-75, 76-80, and >80 years old) with hematologic malignancies included in the EPICOVIDEHA registry between January 2020 and July 2022. Univariable and multivariable Cox regression models were conducted to identify factors influencing death in COVID-19 patients with hematological malignancy., [Results] The study included data from 3,603 elderly patients (aged 65 or older) with hematological malignancy, with a majority being male (58.1%) and a significant proportion having comorbidities. The patients were divided into four age groups, and the analysis assessed COVID-19 outcomes, vaccination status, and other variables in relation to age and pandemic waves. The 90-day survival rate for patients with COVID-19 was 71.2%, with significant differences between groups. The pandemic waves had varying impacts, with the first wave affecting patients over 80 years old, the second being more severe in 65-70, and the third being the least severe in all age groups. Factors contributing to 90-day mortality included age, comorbidities, lymphopenia, active malignancy, acute leukemia, less than three vaccine doses, severe COVID-19, and using only corticosteroids as treatment., [Conclusion] These data underscore the heterogeneity of elderly hematological patients, highlight the different impacts of COVID-19 waves and the pivotal importance of vaccination, and may help in planning future healthcare efforts.

Published
2023

48. Other malignancies in the history of CLL: an international multicenter study conducted by ERIC, the European Research Initiative on CLL, in HARMONY

Author

AbbVie Pharmaceuticals, European Commission, Chatzikonstantinou, Thomas, Scarfò, Lydia, Karakatsoulis, Georgios, Minga, Eva, Chamou, Dimitra, Iacoboni, Gloria, Kotaskova, Jana, Demosthenous, Christos, Smolej, Lukas, Mulligan, Stephen, Alcoceba, Miguel, Kreitman, Robert J., Labrador, Jorge, Lad, Deepesh, Levin, Mark-David, Levy, Ilana, Longval, Thomas, López-García, Alberto, Marquet, Juan, Martín-Rodríguez, Lucía, Maynadié, Marc, Tadmor, Tamar, Maslejova, Stanislava, Mayor-Bastida, Carlota, Mihaljevic, Biljana, Milosevic, Ivana, Mirás, Fátima, Moia, Riccardo, Morawska, Marta, Murru, Roberta, Nath, Uttam Kumar, Navarro-Bailón, Almudena, Tomic, Kristina, Oliveira, Ana C., Olivieri, Jacopo, Oscier, David, Panovska-Stavridis, Irina, Papaioannou, María, Papajík, Tomás, Kubova, Zuzana, Phumphukhieo, Punyarat, Pierie, Cheyenne, Puiggros, Anna, Tse, Eric, Rani, Lata, Reda, Gianluigi, Rigolin, Gian Matteo, Ruchlemer, Rosa, Daniel de Deus Santos, Marcos, Schipani, Mattia, Schiwitza, Annett, Shen, Yandong, Simkovic, Martín, Smirnova, Svetlana, Vassilakopoulos, Theodoros, Abdelrahman Soliman, Dina Sameh, Spacek, Martin, Visentin, Andrea, Vitale, Candida, von Tresckow, Julia, Vrachiolias, George, Vukovic, Vojin, Walewska, Renata, Al-Shemari, Salem, Wasik-Szczepanek, Ewa, Xu, Zhenshu, Yagci, Munci, Yañez, Lucrecia, Yassin, Mohamed, Zuchnicka, Jana, Angelopoulou, Maria, Antic, Darko, Biderman, Bella, Catherwood, Mark, Aurran-Schleinitz, Thérèse, Claus, Rainer, Coscia, Marta, Cuneo, Antonio, Demirkan, Fatih, Espinet, Blanca, Gaidano, Gianluca, Kalashnikova, Olga B., Laurenti, Luca, Nikitin, Eugene, Pangalis, Gerassimos A., Bacchiarri, Francesca, Panagiotidis, Panagiotis, Popov, Viola María, Pospisilova, Sarka, Sportoletti, Paolo, Stavroyianni, Niki, Tam, Constantine S., Trentin, Livio, Chatzidimitriou, Anastasia, Bosch, Francesc, Doubek, Michael, Bellido, Mar, Ghia, Paolo, Stamatopoulos, Kostas, Bijou, Fontanet, Calleja, Anne, Medina, Angeles, Khan, Mehreen Ali, Cassin, Ramona, Chatzileontiadou, Sofía, Collado, Rosa, Christian, Amy, Davis, Zadie, Dimou, María, Donaldson, David, Santos, Gimena Dos, Dreta, Bárbara, Efstathopoulou, María, El-Ashwah, Shaimaa, Enrico, Alicia, Fresa, Alberto, Galimberti, Sara, Galitzia, Andrea, García-Serra, Rocío, Gimeno, Eva, González-Gascón y Marín, Isabel, Gozzetti, Alessandro, Guarente, Valerio, Guieze, Romain, Gogia, Ajay, Gupta, Ritu, Harrop, Sean, Hatzimichael, Eleftheria, Herishanu, Yair, Hernández-Rivas, José Ángel, Inchiappa, Luca, Jaksic, Ozren, Janssen, Susanne, Kalicińska, Elżbieta, Kamel, Laribi, Karakus, Volkan, Kater, Arnon P., Kho, Bonnie, Kislova, María, Konstantinou, Eliana, Koren-Michowitz, Maya, Kotsianidis, Ioannis, AbbVie Pharmaceuticals, European Commission, Chatzikonstantinou, Thomas, Scarfò, Lydia, Karakatsoulis, Georgios, Minga, Eva, Chamou, Dimitra, Iacoboni, Gloria, Kotaskova, Jana, Demosthenous, Christos, Smolej, Lukas, Mulligan, Stephen, Alcoceba, Miguel, Kreitman, Robert J., Labrador, Jorge, Lad, Deepesh, Levin, Mark-David, Levy, Ilana, Longval, Thomas, López-García, Alberto, Marquet, Juan, Martín-Rodríguez, Lucía, Maynadié, Marc, Tadmor, Tamar, Maslejova, Stanislava, Mayor-Bastida, Carlota, Mihaljevic, Biljana, Milosevic, Ivana, Mirás, Fátima, Moia, Riccardo, Morawska, Marta, Murru, Roberta, Nath, Uttam Kumar, Navarro-Bailón, Almudena, Tomic, Kristina, Oliveira, Ana C., Olivieri, Jacopo, Oscier, David, Panovska-Stavridis, Irina, Papaioannou, María, Papajík, Tomás, Kubova, Zuzana, Phumphukhieo, Punyarat, Pierie, Cheyenne, Puiggros, Anna, Tse, Eric, Rani, Lata, Reda, Gianluigi, Rigolin, Gian Matteo, Ruchlemer, Rosa, Daniel de Deus Santos, Marcos, Schipani, Mattia, Schiwitza, Annett, Shen, Yandong, Simkovic, Martín, Smirnova, Svetlana, Vassilakopoulos, Theodoros, Abdelrahman Soliman, Dina Sameh, Spacek, Martin, Visentin, Andrea, Vitale, Candida, von Tresckow, Julia, Vrachiolias, George, Vukovic, Vojin, Walewska, Renata, Al-Shemari, Salem, Wasik-Szczepanek, Ewa, Xu, Zhenshu, Yagci, Munci, Yañez, Lucrecia, Yassin, Mohamed, Zuchnicka, Jana, Angelopoulou, Maria, Antic, Darko, Biderman, Bella, Catherwood, Mark, Aurran-Schleinitz, Thérèse, Claus, Rainer, Coscia, Marta, Cuneo, Antonio, Demirkan, Fatih, Espinet, Blanca, Gaidano, Gianluca, Kalashnikova, Olga B., Laurenti, Luca, Nikitin, Eugene, Pangalis, Gerassimos A., Bacchiarri, Francesca, Panagiotidis, Panagiotis, Popov, Viola María, Pospisilova, Sarka, Sportoletti, Paolo, Stavroyianni, Niki, Tam, Constantine S., Trentin, Livio, Chatzidimitriou, Anastasia, Bosch, Francesc, Doubek, Michael, Bellido, Mar, Ghia, Paolo, Stamatopoulos, Kostas, Bijou, Fontanet, Calleja, Anne, Medina, Angeles, Khan, Mehreen Ali, Cassin, Ramona, Chatzileontiadou, Sofía, Collado, Rosa, Christian, Amy, Davis, Zadie, Dimou, María, Donaldson, David, Santos, Gimena Dos, Dreta, Bárbara, Efstathopoulou, María, El-Ashwah, Shaimaa, Enrico, Alicia, Fresa, Alberto, Galimberti, Sara, Galitzia, Andrea, García-Serra, Rocío, Gimeno, Eva, González-Gascón y Marín, Isabel, Gozzetti, Alessandro, Guarente, Valerio, Guieze, Romain, Gogia, Ajay, Gupta, Ritu, Harrop, Sean, Hatzimichael, Eleftheria, Herishanu, Yair, Hernández-Rivas, José Ángel, Inchiappa, Luca, Jaksic, Ozren, Janssen, Susanne, Kalicińska, Elżbieta, Kamel, Laribi, Karakus, Volkan, Kater, Arnon P., Kho, Bonnie, Kislova, María, Konstantinou, Eliana, Koren-Michowitz, Maya, and Kotsianidis, Ioannis

Abstract

[Background]: Patients with chronic lymphocytic leukemia (CLL) have a higher risk of developing other malignancies (OMs) compared to the general population. However, the impact of CLL-related risk factors and CLL-directed treatment is still unclear and represents the focus of this work., [Methods]: We conducted a retrospective international multicenter study to assess the incidence of OMs and detect potential risk factors in 19,705 patients with CLL, small lymphocytic lymphoma, or high-count CLL-like monoclonal B-cell lymphocytosis, diagnosed between 2000 and 2016. Data collection took place between October 2020 and March 2022., [Findings]: In 129,254 years of follow-up after CLL diagnosis, 3513 OMs were diagnosed (27.2 OMs/1000 person-years). The most common hematological OMs were Richter transformation, myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Non-melanoma skin (NMSC) and prostate cancers were the most common solid tumors (STs). The only predictor for MDS and AML development was treatment with fludarabine and cyclophosphamide with/without rituximab (FC ± R) (OR = 3.7; 95% CI = 2.79–4.91; p < 0.001). STs were more frequent in males and patients with unmutated immunoglobulin heavy variable genes (OR = 1.77; 95% CI = 1.49–2.11; p < 0.001/OR = 1.89; 95% CI = 1.6–2.24; p < 0.001). CLL-directed treatment was associated with non-melanoma skin and prostate cancers (OR = 1.8; 95% CI = 1.36–2.41; p < 0.001/OR = 2.11; 95% CI = 1.12–3.97; p = 0.021). In contrast, breast cancers were more frequent in untreated patients (OR = 0.17; 95% CI = 0.08–0.33; p < 0.001). Patients with CLL and an OM had inferior overall survival (OS) than those without. AML and MDS conferred the worst OS (p < 0.001)., [Interpretation]: OMs in CLL impact on OS. Treatment for CLL increased the risk for AML/MDS, prostate cancer, and NMSC. FCR was associated with increased risk for AML/MDS.

Published
2023

50. Karaciğer Naklinde ve Kronik Viral Hepatitli Hastalarda Prohepsidin ve Demir Parametrelerinin Değişiminin Araştırılması

Author

Yuksel, Faize, AKARSU, Mesut, ÖZDEMİR, Özlem, TOSUN TAŞAR, Pınar, DEMİRKAN, Fatih, KARADEMİR, Sedat, ÜNEK, TARKAN, and BACAKOĞLU, Aylin

Abstract

Amaç: Çalışmamızda, karaciğerde sentezlenen ve demir regülasyonunda anahtar role sahip olan hepsidinin kronik viral hepatit, siroz ve nakil sonrası hepsidin düzeyindeki değişimin karaciğer fonksiyon testleri ve demir parametreleri ile ilişkisini değerlendirmeyi amaçladık. Gereç ve Yöntem: Hasta popülasyonu, Grup 1: inaktif kronik hepatit B (n=31); Grup 2: kronik hepatit C (n=30); Grup 3: Hepatit C virüs (HCV) veya hepatit B virüse (HBV) bağlı dekompanse siroz (n=29); Grup 4: HCV ya da HBV nedeniyle dekompanse siroz gelişip karaciğer nakli yapılan hastalar (n=31) olarak dağıtıldı. Bulgular: Tüm guruplar ele alındığında yaş, cinsiyet, Hb, AST, ALP, GGT, LDH, T. bil; albumin, toplam kolesterol, yüksek yoğunluklu lipoprotein, SDBK ve transferrin satürasyonunda (TS) fark saptandı. Kronik inaktif HBV ile kronik HCV hastaları arasında Hb, AST, ALP, albumin ve prohepsidin düzeyleri arasında anlamlı fark saptanmış olup prohepsidin düzeyi HCV olgularında daha fazla bulundu (p

Published
2023

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