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3. The marine polysaccharide ulvan confers potent osteoinductive capacity to pcl‐based scaffolds for bone tissue engineering applications

Author

Kikionis, S. Ioannou, E. Aggelidou, E. Tziveleka, L.-A. Demiri, E. Bakopoulou, A. Zinelis, S. Kritis, A. Roussis, V.

Abstract

Hybrid composites of synthetic and natural polymers represent materials of choice for bone tissue engineering. Ulvan, a biologically active marine sulfated polysaccharide, is attracting great interest in the development of novel biomedical scaffolds due to recent reports on its osteoinductive properties. Herein, a series of hybrid polycaprolactone scaffolds containing ulvan either alone or in blends with κ‐carrageenan and chondroitin sulfate was prepared and characterized. The impact of the preparation methodology and the polysaccharide composition on their morphology, as well as on their mechanical, thermal, water uptake and porosity properties was determined, while their osteoinductive potential was investigated through the evaluation of cell adhesion, viability, and osteogenic differentiation of seeded human adipose‐derived mesenchymal stem cells. The results verified the osteoinductive ability of ulvan, showing that its incorporation into the polycaprolactone matrix efficiently promoted cell attachment and viability, thus confirming its potential in the development of biomedical scaffolds for bone tissue regeneration applications. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Published
2021

4. Secondary Lymphedema Treatment With Vascularized Lymph Node Transplantation.

Author

Sarafis, A., Demiri, E., Tsimponis, A., Tatsidou, G., Panagou, A., Arsos, G., and Dionyssiou, D.

Subjects
LYMPHEDEMA treatment, OPERATIVE surgery, LYMPH nodes, LYMPHEDEMA, MICROSURGERY
Abstract

Microsurgical methods, such as free vascularized lymph node transfer (VLNT) and lymphatico-venous anastomosis (LVA), have been increasingly used in the last two decades to treat lymphedema patients. The aim of our study was to evaluate the effectiveness of VLNT in the management of upper and lower limb secondary lymphedema in a long-term follow-up period. During a period of 8 years, 782 patients were examined in our lymphedema clinic with primary or secondary upper or lower limb lymphedema. From a total of 137 surgically managed patients, 92 underwent a VLNT. Their mean age was 48.3 years and mean BMI 28.4. The values concerning the volume of the affected limbs, the infection rates, the feeling of pain and heaviness and the overall function, were measured at the induction of patients in the study and at the last follow-up appointment. Follow-up ranged from 28 to 120 months. Postoperative lymphoscintigraphy of the operated patients showed positive findings in 78,9% of our cases. The mean volume of the affected limb was decreased by 55.2% at the last follow-up examination, the infection episodes were significantly reduced, and all patients reported significant reduction of pain and feeling of heaviness of the affected extremity with an overall functional improvement. The vascularized lymph node transfer represents an effective microsurgical procedure in volume reduction, decrease of infections, and functional improvement of secondary upper and lower limb lymphedema patients. [ABSTRACT FROM AUTHOR]

Published
2022

5. Hybrid sponge-like scaffolds based on ulvan and gelatin: Design, characterization and evaluation of their potential use in bone tissue engineering

Author

Tziveleka, L.-A. Sapalidis, A. Kikionis, S. Aggelidou, E. Demiri, E. Kritis, A. Ioannou, E. Roussis, V.

Abstract

Ulvan, a bioactive natural sulfated polysaccharide, and gelatin, a collagen-derived biopolymer, have attracted interest for the preparation of biomaterials for different biomedical applications, due to their demonstrated compatibility for cell attachment and proliferation. Both ulvan and gelatin have exhibited osteoinductive potential, either alone or in combination with other materials. In the current work, a series of novel hybrid scaffolds based on crosslinked ulvan and gelatin was designed, prepared and characterized. Their mechanical performance, thermal stability, porosity, water-uptake and in vitro degradation ability were assessed, while their morphology was analyzed through scanning electron microscopy. The prepared hybrid ulvan/gelatin scaffolds were characterized by a highly porous and interconnected structure. Human adipose-derived mesenchymal stem cells (hADMSCs) were seeded in selected ulvan/gelatin hybrid scaffolds and their adhesion, survival, proliferation, and osteogenic differentiation efficiency was evaluated. Overall, it was found that the prepared hybrid sponge-like scaffolds could efficiently support mesenchymal stem cells' adhesion and proliferation, suggesting that such scaffolds could have potential uses in bone tissue engineering. © 2020 by the authors.

Published
2020

7. A critical survey of a dedicated craniofacial surgery outpatient's clinic within a public health service structure

Author

Pericles Foroglou, Farmakis, G., Antoniou, A., and Demiri, E.

Subjects
Adult, Aged, 80 and over, Male, Patient Care Team, Adolescent, Middle Aged, Plastic Surgery Procedures, Hospitals, General, United States, Craniofacial Abnormalities, Young Adult, Ambulatory Surgical Procedures, Outpatients, Humans, Female, Interdisciplinary Communication, Community Health Services, Public Health, Surgery, Plastic, Child, Aged
Abstract

The management of craniofacial conditions, especially in the setting of a large general hospital, is ideally achieved by a focused team in a multidisciplinary clinic. The purpose of this article was to present the design, modus operandi and outcomes of a newly formed dedicated craniofacial multidisciplinary outpatients' clinic at the first year of operation endpoint within a public healthcare structure.

Published
2019

9. Abstract P3-04-04: Germline and somatic mutation status in tissues from BRCA1/2 carriers

Author

Kotoula, V, primary, Demiri, E, additional, Fostira, F, additional, Vrettou, E, additional, Papadopoulou, K, additional, Tikas, I, additional, Papazisis, K, additional, Zaramboukas, T, additional, Asimaki-Vlachopoulou, A, additional, Miliaras, S, additional, Fountzilas, E, additional, Ananiadis, A, additional, Chrisafi, S, additional, Poulios, C, additional, Natsiopoulos, I, additional, Tsiftsoglou, A, additional, and Fountzilas, G, additional

Published
2018
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11. Patient-private disease evolution and heterogeneity in bilateral breast cancer

Author

Fountzila, E., primary, Kotoula, V., additional, Zagouri, F., additional, Giannoulatou, E., additional, Kouvatseas, G., additional, Pentheroudakis, G., additional, Koletsa, T., additional, Bobos, M., additional, Papadopoulou, K., additional, Samantas, E., additional, Demiri, E., additional, Miliaras, S., additional, Christodoulou, C., additional, Chrisafi, S., additional, Razis, E., additional, Fostira, F., additional, Pectasides, D., additional, Zografos, G., additional, and Fountzilas, G., additional

Published
2016
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12. Rare benign tumours of the nipple

Author

Spyropoulou, G.A., primary, Pavlidis, L., additional, Trakatelli, M., additional, Athanasiou, E., additional, Pazarli, E., additional, Sotiriadis, D., additional, and Demiri, E., additional

Published
2014
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14. OP-195 EVALUATION OF RELATIONSHIP BETWEEN ENDOTHELIAL FUNCTIONS AND INTRA–INTERATRIAL CONDUCTION PROPERTIES IN PATIENTS WITH LONE PAROXYSMAL ATRIAL FIBRILLATION

Author

Ülgen, A., primary, Kunak, T., additional, Demiri, E., additional, Taher, A., additional, Canpolat, U., additional, Sunman, H., additional, Maharjan, N., additional, Muhtarov, K., additional, Şahiner, L., additional, Kaya, E.B., additional, Aytemir, K., additional, and Oto, A., additional

Published
2013
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17. OP-031 DIAGNOSTIC ACCURACY OF DUAL SOURCE 64-SLICE COMPUTED TOMOGRAPHY FOR DETECTION OF ARTERIAL GRAFT AND ANASTOMOTIC NATIVE VESSEL PATENCY IN CORONARY BYPASS PATIENTS

Author

Canpolat, U., primary, Yorgun, H., additional, Hazırolan, T., additional, Sunman, H., additional, Ülgen, A., additional, Demiri, E., additional, Şahiner, L., additional, Kaya, E.B., additional, Tokgözoglu, L., additional, Kabakçı, G., additional, Oto, A., additional, and Aytemir, K., additional

Published
2013
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21. OP-100 TRANSVENOUS EXTRACTION OF PACEMAKER AND IMPLANTABLE CARDIOVERTER DEFIBRILLATOR LEADS USING NEW TECHNOLOGY; EVOLUTION MECHANICAL DILATOR SHEATH

Author

Oto, A., primary, Aytemir, K., additional, Canpolat, U., additional, Yorgun, H., additional, Sunman, H., additional, Ülgen, A., additional, Demiri, E., additional, Gurses, K.M., additional, Sahiner, L., additional, Kaya, E.B., additional, Tokgozoglu, L., additional, and Kabakçi, G., additional

Published
2012
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30. OP-092: ASSOCIATION BETWEEN FAMILY HISTORY OF PREMATURE CORONARY ARTERY DISEASE AND CORONARY ATHEROSCLEROTIC PLAQUES SHOWN BY MULTIDETECTOR COMPUTED TOMOGRAPHY CORONARY ANGIOGRAPHY

Author

Sunman, H., primary, Yorgun, H., additional, Canpolat, U., additional, Ates, A.H., additional, Dural, M., additional, Demiri, E., additional, Hazirolan, T., additional, Kaya, E.B., additional, Aytemir, K., additional, Tokgozoglu, L., additional, Kabakci, G., additional, and Oto, A., additional

Published
2011
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40. The Wash-Out Technique in the Management of Delayed Presentations of Extravasation Injuries.

Author

DIONYSSIOU, D., CHANTES, A., GRAVVANIS, A., and DEMIRI, E.

Subjects
EXTRAVASATION, DRUG side effects, ARM injuries, NECROSIS, SKIN diseases, THERAPEUTICS
Abstract

Late presentation of extravasation injuries from chemotherapeutic agents is not uncommon. Twenty-four patients with extravasation injuries presented with upper limb extravasation but without any skin necrosis between the second and the fourteenth day following injury day. We flushed out the infiltrated area with 300—500 ml of normal saline through multiple stab incisions. All 24 patients responded well to the procedure and no further complications occurred. The average time for the complete healing of the wounds was 15 days. All the patients were able to continue their chemotherapy treatment without delay. Patients were followed up for a mean period of 13 months. They all recovered with no functional deficit and only mild scarring. Early recognition and immediate treatment of extravasation injuries are of paramount importance. In cases with no evidence of skin necrosis, a delayed wash-out procedure appears to be very effective in removing the extravasated drug and minimizing further tissue damage. [ABSTRACT FROM PUBLISHER]

Published
2011
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