1. Self-Assessed Severity as a Determinant of Coronavirus Disease 2019 Symptom Specificity: A Longitudinal Cohort Study
- Author
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Bershteyn, Anna, Dahl, Angela M, Dong, Tracy Q, Deming, Meagan E, Celum, Connie L, Chu, Helen Y, Kottkamp, Angelica C, Greninger, Alexander L, Hoffman, Risa M, Jerome, Keith R, Johnston, Christine M, Kissinger, Patricia J, Landovitz, Raphael J, Laufer, Miriam K, Luk, Alfred, Neuzil, Kathleen M, Paasche-Orlow, Michael K, Pitts, Robert A, Schwartz, Mark D, Stankiewicz Karita, Helen C, Thorpe, Lorna E, Wald, Anna, Zheng, Crystal Y, Wener, Mark H, Barnabas, Ruanne V, and Brown, Elizabeth R
- Subjects
Prevention ,Biodefense ,Clinical Research ,Emerging Infectious Diseases ,Infectious Diseases ,Vaccine Related ,Pneumonia & Influenza ,Pneumonia ,Lung ,Good Health and Well Being ,COVID-19 ,COVID-19 Testing ,Humans ,Longitudinal Studies ,SARS-CoV-2 ,symptoms ,screening ,severity ,Biological Sciences ,Medical and Health Sciences ,Microbiology - Abstract
Coronavirus disease 2019 symptom definitions rarely include symptom severity. We collected daily nasal swab samples and symptom diaries from contacts of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) case patients. Requiring ≥1 moderate or severe symptom reduced sensitivity to predict SARS-CoV-2 shedding from 60.0% (95% confidence interval [CI], 52.9%-66.7%) to 31.5% (95% CI, 25.7%- 38.0%) but increased specificity from 77.5% (95% CI, 75.3%-79.5%) to 93.8% (95% CI, 92.7%-94.8%).
- Published
- 2022