Search

Your search keyword '"Demetra D. Koutra"' showing total 2 results
Start Over Author "Demetra D. Koutra"
2 results on '"Demetra D. Koutra"'

1. ChemInform Abstract: Potent Inhibition of Glycogen Phosphorylase by a Spirohydantoin of Glucopyranose: First Pyranose Analogues of Hydantocidin

Author

George W. J. Fleet, Nikos G. Oikonomakos, Mark R. Wormald, Spyros E. Zographos, C. J. F. Bichard, Kimberly A. Watson, Louise N. Johnson, Demetra D. Koutra, and E. P. Mitchell

Subjects
Glycogen phosphorylase, Anomer, Pyranose, Stereochemistry, Chemistry, Epimer, General Medicine, Specific enzyme, Hydantocidin
Abstract

The synthesis of two epimeric spirohydantoins of glucopyranose provides the first examples of pyranose analogues of hydantocidin: molecular modelling correctly predicted that one of the epimers would be a potent inhibitor of glycogen phosphorylase. This is the first example of specific enzyme inhibition by a spirohydantoin at the anomeric position of a sugar.

Published
2010
Full Text
View/download PDF

2. Potent Inhibition of Glycogen-Phosphorylase by a Spirohydantoin of Glucopyranose - First Pyranose Analogs of Hydantocidin

Author

George W. J. Fleet, Louise N. Johnson, Spyros E. Zographos, Kimberly A. Watson, Demetra D. Koutra, Nikos G. Oikonomakos, E. P. Mitchell, C. J. F. Bichard, and Mark R. Wormald

Subjects
Glycogen phosphorylase, Anomer, Pyranose, Chemistry, Stereochemistry, Organic Chemistry, Drug Discovery, Organic chemistry, Epimer, Biochemistry, Specific enzyme, Hydantocidin
Abstract

The synthesis of two epimeric spirohydantoins of glucopyranose provides the first examples of pyranose analogues of hydantocidin: molecular modelling correctly predicted that one of the epimers would be a potent inhibitor of glycogen phosphorylase. This is the first example of specific enzyme inhibition by a spirohydantoin at the anomeric position of a sugar.

Published
2008

Catalog

Books, media, physical & digital resources
See catalog results