237 results on '"Demeret S"'
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2. Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection
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Marchal, A, Cirulli, E, Neveux, I, Bellos, E, Thwaites, R, Schiabor Barrett, K, Zhang, Y, Nemes-Bokun, I, Kalinova, M, Catchpole, A, Tangye, S, Spaan, A, Lack, J, Ghosn, J, Burdet, C, Gorochov, G, Tubach, F, Hausfater, P, Abel, L, Aiuti, A, Al-Muhsen, S, Al-Mulla, F, Amara, A, Anderson, M, Andreakos, E, Arias, A, Arkin, L, Feldman, H, Bastard, P, Belot, A, Biggs, C, Bogunovic, D, Bolze, A, Bondarenko, A, Borghesi, A, Bousfiha, A, Brodin, P, Bryceson, Y, Butte, M, Casanova, J, Casari, G, Christodoulou, J, Cobat, A, Colobran, R, Condino-Neto, A, Constantinescu, S, Cooper, M, Dalgard, C, Desai, M, Drolet, B, Duval, X, El Baghdadi, J, Eloy, P, Espinosa-Padilla, S, Fellay, J, Flores, C, Franco, J, Froidure, A, Gregersen, P, Grimbacher, B, Haerynck, F, Hagin, D, Halwani, R, Hammarstrom, L, Heath, J, Hsieh, E, Husebye, E, Imai, K, Itan, Y, Jouanguy, E, Kaja, E, Karamitros, T, Kisand, K, Ku, C, Lau, Y, Ling, Y, Lucas, C, Maniatis, T, Mansouri, D, Marodi, L, Mentre, F, Meyts, I, Milner, J, Mironska, K, Mogensen, T, Morio, T, Ng, L, Notarangelo, L, Novelli, A, Novelli, G, O'Farrelly, C, Okada, S, Okamoto, K, Ozcelik, T, Pan-Hammarstrom, Q, Pape, J, Perez de Diego, R, Perez-Tur, J, Perlin, D, Pesole, G, Planas, A, Prando, C, Pujol, A, Puel, A, Quintana-Murci, L, Ramaswamy, S, Renia, L, Resnick, I, Rodriguez-Gallego, C, Sancho-Shimizu, V, Sediva, A, Seppanen, M, Shahrooei, M, Shcherbina, A, Slaby, O, Snow, A, Soler-Palacin, P, Soumelis, V, Tancevski, I, Tayoun, A, Temel, S, Thorball, C, Tiberghien, P, Trouillet-Assant, S, Turvey, S, Uddin, K, Uddin, M, van de Beek, D, Vinh, D, von Bernuth, H, Wauters, J, Zatz, M, Zawadzki, P, Zhang, Q, Zhang, S, Bureau, S, Vacher, Y, Gysembergh-Houal, A, Demerville, L, Benleulmi-Chaachoua, A, Abad, S, Abassi, R, Abdellaoui, A, Abdelmalek, A, Abdoul, H, Abergel, H, Abeud, F, Abgrall, S, Abisror, N, Adechian, M, Aderdour, N, Admane, H, Adnet, F, Afritt, S, Agostini, H, Aguilar, C, Agut, S, Aiello, T, Kaci, M, Oufella, H, Ajeenthiravasan, G, Alauzy, V, Alby-Laurent, F, Allard, L, Alyanakian, M, Borrero, B, Amam, S, Amrouche, L, Andronikof, M, Anglicheau, D, Anguel, N, Annane, D, Aounzou, M, Aparicio, C, Aratus, G, Arlet, J, Arzoine, J, Aslangul, E, Assefi, M, Aubry, A, Audiffred, L, Audureau, E, Auger, C, Auregan, J, Awotar, C, Milla, S, Azan, D, Azemar, L, Azzouguen, B, Elrufaai, M, Badsi, A, Bakouboula, P, Balcerowiak, C, Balde, F, Baldivia, E, Bangamingo, E, Baptiste, A, Baran-Marszak, F, Barau, C, Barget, N, Baronnet, F, Barthelemy, R, Baudel, J, Baudry, C, Baudry, E, Beaugerie, L, Belamri, A, Belaube, N, Belilita, R, Bellassen, P, Belmokhtar, R, Beltran, I, Benainous, R, Benallaoua, M, Benamouzig, R, Benbara, A, Benhida, J, Benkhelouf, A, Benlagha, J, Benmostafa, C, Benothmane, S, Bentifraouine, M, Berard, L, Bernier, Q, Berti, E, Bertier, A, Berton, L, Bessis, S, Beurton, A, Bianco, C, Bianquis, C, Bidar, F, Blanche, P, Blayau, C, Bleibtreu, A, Blin, E, Bloch-Queyrat, C, Boissier, M, Bollens, D, Bolzoni, M, Bompard, R, Bonnet, N, Bonnouvrier, J, Botha, S, Boucenna, W, Bouchama, F, Bouchaud, O, Bouchghoul, H, Boudjebla, T, Boudjema, N, Bouffard, C, Bougle, A, Bouguerra, M, Bouras, L, Bourcier, A, Durand, A, Bourrier, A, Bouscarat, F, Bouvry, D, Bouziri, N, Bouzrara, O, Bribier, S, Brugier, D, Brunel, M, Bui, E, Buisson, A, Bukreyeva, I, Bureau, C, Cadranel, J, Cailhol, J, Calin, R, Vega, C, Canavaggio, P, Cancella, M, Cantin, D, Cao, A, Carbillon, L, Carlier, N, Cassard, C, Castor, G, Cauchy, M, Cha, O, Chaigne, B, Challal, S, Champion, K, Chariot, P, Chas, J, Chauveau, S, Chauvin, A, Chauvin, C, Chavarot, N, Chebbout, K, Cherai, M, Cherubini, I, Chevalier, A, Chiarabini, T, Chinet, T, Chocron, R, Choinier, P, Chommeloux, J, Choquet, C, Choupeaux, L, Chousterman, B, Ciocan, D, Clarke, A, Clavere, G, Clavier, F, Clement, K, Clerc, S, Cohen, Y, Cohen, F, Cohen, A, Coilly, A, Colboc, H, Colin, P, Collet, M, Comarmond, C, Combacon, E, Combes, A, Comparon, C, Constantin, J, Cordel, H, Cordier, A, Costantini, A, Chalumeau, N, Couffignal, C, Coupeau, D, Creange, A, Lamarre, Y, Da Silveira, C, Guibal El Kayani, S, De Castro, N, De Rycke, Y, Del Pozo, L, Delannoy, Q, Delay, M, Deleris, R, Delforge, J, Delphine, L, Demare, N, Demeret, S, Demoule, A, Deniau, A, Depret, F, Derolez, S, Derradji, O, Derridj, N, Descamps, V, Deschamps, L, Desconclois, C, Desnos, C, Desongins, K, Dhote, R, Diallo, B, Didier, M, Diemer, M, Diez, S, Djadi-Prat, J, Djamouri Monnory, F, Djebara, S, Djebra, N, Djietcheu, M, Djillali, H, Djouadi, N, Donneger, S, Santos, C, Dournon, N, Dres, M, Droctove, L, Drogrey, M, Dropy, M, Drouet, E, Dubosq, V, Dubreucq, E, Dubus, E, Duchemann, B, Duchenoy, T, Dudoignon, E, Dufau, R, Dumas, F, Duran, C, Duron, E, Durrbach, A, Duvivier, C, Ebstein, N, El Khalifa, J, Elabbadi, A, Elie, C, Ernotte, G, Esling, A, Etienne, M, Eyer, X, Fartoukh, M, Fayali, T, Fermaut, M, Fiorentino, A, Fliss, S, Fournier, M, Fournier, B, Francois, H, Freynet, O, Frigout, Y, Fromont, I, Fuentes, A, Furet, T, Galand, J, Garnier, M, Gaubert, A, Gaudry, S, Gaugain, S, Gauthier, D, Gautier, M, Georgin-Lavialle, S, Geromin, D, Ghalayini, M, Ghaleh, B, Ghezal, M, Gibelin, A, Gimeno, L, Girard, B, Leprieur, B, Gomes, D, Gomes-Pires, E, Gouge, A, Gouja, A, Goulet, H, Goupil, S, De Bouille, J, Gras, J, Greffe, S, Grimaldi, L, Guedeney, P, Guidet, B, Guillo, M, Gulczynski, M, Hadjam, T, Haguenauer, D, Hammal, S, Hammoudi, N, Hanon, O, Harrois, A, Hautem, C, Hekimian, G, Heming, N, Hermine, O, Ho, S, Houllier, M, Huot, B, Huscenot, T, Saied, W, Ikherbane, G, Imarazene, M, Ingiliz, P, Iratni, L, Jaureguiberry, S, Jean-Marc, J, Jeyarajasingham, D, Jouany, P, Jouis, V, Jourdaine, C, Kafif, O, Kallala, R, Katsahian, S, Kelesyan, L, Keo, V, Ketz, F, Khamis, W, Khelili, E, Khellaf, M, Kotokpo Youkou, C, Kounis, I, Kpalma, G, Krause, J, Labbe, V, Lacombe, K, Lacorte, J, Lafont, A, Lafont, E, Lagha, L, Lamhaut, L, Lancelot, A, Landman, C, Lanternier, F, Larcheveque, C, Combe, C, Lassel, L, Laverdant, B, Lavergne, C, Lavillegrand, J, Lazureanu, P, Le Guennec, L, Leberre, L, Leblanc, C, Leboyer, M, Lecomte, F, Lecorre, M, Leenhardt, R, Lefebvre, M, Lefebvre, B, Legendre, P, Leger, A, Legros, L, Legrosse, J, Lehuunghia, S, Lemarec, J, Leporrier-Ext, J, Lesein, M, Lesur, H, Levy, V, Levy, A, Lopes, E, Lopes, A, Lopez, V, Lopinto, J, Lortholary, O, Louadah, B, Loze, B, Lucas, M, Lucasamichi, A, Luong, L, Magazimama-Ext, A, Maingret, D, Mameri, L, Manivet, P, Mansouri, C, Marcault, E, Marey, J, Marin, N, Marois, C, Martin, O, Martineau, L, Martinez-Lopez, C, Martyniuck, P, De Farcy, P, Marzouk, N, Masmoudi, R, Mebazaa, A, Mechai, F, Mecozzi, F, Mediouni, C, Megarbane, B, Meghadecha, M, Mejean, E, Mekinian, A, Abdelhadi, N, Mekni, R, Meliti, T, Lima, B, Meng, P, Merbah, S, Messani, F, Messaoudi, Y, Mewasing, B, Meziane, L, Michelot-Burger, C, Mignot, F, Minka, F, Miyara, M, Moine, P, Molina, J, Montegnies-Boulet, A, Monti, A, Montlahuc, C, Montout, A, Moores, A, Morbieu, C, Mortelette, H, Mouly, S, Muzaffar, R, Nacerddine, C, Nadal, M, Nadif, H, Nassarmadji, K, Natella, P, Ndingamondze, S, Neraal, S, Nguyen, C, N'Guyen, B, Larmurier, I, Nlomenyengue, L, Noel, N, Nunes, H, Omar, E, Ouazene, Z, Ouedraogo, E, Ouelaa, W, Oukhedouma, A, Amara, Y, Oya, H, Oziel, J, Padilla, T, Paillaud, E, Paiva, S, Parfait, B, Parize, P, Parizot, C, Parrot, A, Pavot, A, Peaudecerf, L, Pene, F, Pepin, M, Pernet, J, Pernin, C, Petit, M, Peyrony, O, Pietri, M, Pietri, O, De Chambrun, M, Pinson, M, Pintado, C, Piquard, V, Pires, C, Planquette, B, Poirier, S, Pomel, A, Pons, S, Ponscarme, D, Pourcelot, A, Pourcher, V, Pouvaret, A, Prever, F, Previlon, M, Prevost, M, Provoost, M, Quemeneur, C, Rafat, C, Rami, A, Ranque, B, Raphael, M, Raphalen, J, Rastoin, A, Raux, M, Rebai, A, Reby, M, Regent, A, Regrag, A, Resche-Rigon, M, Ressaire, Q, Richard, C, Richard, M, Robert, M, Rohaut, B, Rolland-Debord, C, Ropers, J, Roque-Afonso, A, Rosso, C, Rousseaux, M, Rousseaux, N, Roux, S, Roux, L, Rouzaud, C, Rozes, A, Rubenstein, E, Sabate, J, Sabet, S, Sacleux, S, Kermanach, N, Saliba, F, Salmon, D, Savale, L, Savary, G, Sberro, R, Scemla, A, Schlemmer, F, Schwartz, M, Sedfi, S, Sefir-Kribel, S, Seksik, P, Sellier, P, Selves, A, Sembach, N, Semerano, L, Senat, M, Sene, D, Serris, A, Sese, L, Sghiouar, N, Sigaux, J, Siguier, M, Silvain, J, Simon, N, Simon, T, Skandri, L, Slimani, M, Snauwaert, A, Sokol, H, Soliman, H, Soltani, N, Soyer, B, Steg, G, Suarez, L, Szwebel, T, Taffame, K, Tandjaoui-Lambiotte, Y, Tantet, C, Tateo, M, Theodose, I, Thiebaud, P, Thomas, C, Tiercelet, K, Tisserand, J, Tomczak, C, Torelino, K, Touam-Ext, F, Toumi, L, Toury, G, Toy-Miou, M, Dinh Thanh Lien, O, Trandinh, A, Treluyer, J, Trinque, B, Truchot, J, Tubiana, S, Tunesi, S, Turpin, M, Turpin, A, Urbina, T, Narvaez, R, Uzunhan, Y, Vaittinadaayar, P, Valent, A, Valentian, M, Valin, N, Vallet, H, Vaz, M, Vazquezibarra, M, Vedie, B, Velly, L, Verstuyft, C, Viallette, C, Vicaut, E, Vignes, D, Vimpere, D, Virlouvet, M, Voiriot, G, Voisot, L, Weiss, E, Weiss, N, Winchenne, A, Yordanov, Y, Zafrani, L, Zaidan, M, Zaidi, W, Zak, C, Zarhrate-Ghoul, A, Zatout, O, Zeino, S, Zeitouni, M, Zemirli, N, Zerah, L, Zia, O, Ziol, M, Zolario, O, Zuber, J, Andrejak, C, Angoulvant, F, Bachelet, D, Bartoli, M, Basmaci, R, Behillil, S, Beluze, M, Benkerrou, D, Bhavsar, K, Bouadma, L, Bouchez, S, Bouscambert, M, Cervantes-Gonzalez, M, Chair, A, Chirouze, C, Coelho, A, Couffin-Cadiergues, S, D'Ortenzio, E, Debray, M, Deconinck, L, Deplanque, D, Descamps, D, Desvallee, M, Diallo, A, Diouf, A, Dorival, C, Dubos, F, Elharrar, B, Enouf, V, Esperou, H, Esposito-Farese, M, Devouge, E, Gault, N, Gaymard, A, Gigante, T, Gilg, M, Guedj, J, Hoctin, A, Hoffmann, I, Houas, I, Hulot, J, Jaafoura, S, Kaguelidou, F, Kali, S, Khalil, A, Khan, C, Laouenan, C, Laribi, S, Le, M, Le Hingrat, Q, Le Mestre, S, Le Nagard, H, Lescure, F, Letrou, S, Levy, Y, Lina, B, Lingas, G, Lucet, J, Malvy, D, Mambert, M, Meziane, A, Mouquet, H, Mullaert, J, Neant, N, Nguyen, D, Noret, M, Nseir, S, Papadopoulos, A, Paul, C, Peiffer-Smadja, N, Perpoint, T, Petrov-Sanchez, V, Peytavin, G, Pham, H, Picone, O, Puechal, O, Rabaud, C, Rosa-Calatrava, M, Rossignol, B, Rossignol, P, Roy, C, Schneider, M, Su, R, Tardivon, C, Tellier, M, Teoule, F, Terrier, O, Timsit, J, Tual, C, van der Werf, S, Vanel, N, Veislinger, A, Visseaux, B, Wiedemann, A, Yazdanpanah, Y, Alavoine, L, Charpentier, C, Dechanet, A, Ecobichon, J, Frezouls, W, Houhou, N, Lehacaut, J, Manchon, P, Nouroudine, M, Quintin, C, Thy, M, Vignali, V, Chahine, A, Waucquier, N, Migaud, M, Djossou, F, Mergeay-Fabre, M, Lucarelli, A, Demar, M, Bruneau, L, Gerardin, P, Maillot, A, Payet, C, Laviolle, B, Laine, F, Paris, C, Desille-Dugast, M, Fouchard, J, Pistone, T, Perreau, P, Gissot, V, Goas, C, Montagne, S, Richard, L, Bouiller, K, Desmarets, M, Meunier, A, Bourgeon, M, Lefevre, B, Jeulin, H, Legrand, K, Lomazzi, S, Tardy, B, Gagneux-Brunon, A, Bertholon, F, Botelho-Nevers, E, Kouakam, C, Nicolas, L, Roufai, L, Amat, K, Hendou, S, Foti, G, Citerio, G, Contro, E, Pesci, A, Valsecchi, M, Cazzaniga, M, Bellani, G, Abad, J, Accordino, G, Angelini, M, Aguilera-Albesa, S, Aguilo-Cucurull, A, Ozkan, E, Darazam, I, Roblero Albisures, J, Aldave, J, Ramos, M, Khan, T, Aliberti, A, Nadji, S, Alkan, G, Alkhater, S, Allardet-Servent, J, Allende, L, Alonso-Arias, R, Alshahrani, M, Alsina, L, Amoura, Z, Antoli, A, Arrestier, R, Aubart, M, Auguet, T, Avramenko, I, Aytekin, G, Azot, A, Bahram, S, Bajolle, F, Baldanti, F, Baldolli, A, Ballester, M, Barrou, B, Barzaghi, F, Basso, S, Bayhan, G, Bezrodnik, L, Bilbao, A, Blanchard-Rohner, G, Blanco, I, Blandinieres, A, Blazquez-Gamero, D, Bloomfield, M, Bolivar-Prados, M, Borie, R, Botdhlo-Nevers, E, Bousquet, A, Boutolleau, D, Bouvattier, C, Boyarchuk, O, Bravais, J, Briones, M, Brunner, M, Bruno, R, Bueno, M, Bukhari, H, Bustamante, J, Caceres Agra, J, Capra, R, Carapito, R, Carrabba, M, Casasnovas, C, Caseris, M, Cassaniti, I, Castelle, M, Castelli, F, Castillo de Vera, M, Castro, M, Catherinot, E, Celik, J, Ceschi, A, Chalumeau, M, Charbit, B, Boulanger, C, Clave, P, Clotet, B, Codina, A, Comoli, P, Corsico, A, Coskuner, T, Cvetkovski, A, Cyrus, C, Dalmau, D, Danion, F, Darley, D, Das, V, Dauby, N, Dauger, S, De Munte, P, de Pontual, L, Dehban, A, Delplancq, G, Desguerre, I, Di Sabatino, A, Diehl, J, Dobbelaere, S, Dominguez-Garrido, E, Dubost, C, Ekwall, O, Bozdemir, S, Elnagdy, M, Emiroglu, M, Endo, A, Erdeniz, E, Aytekin, S, Etxart Lasa, M, Euvrard, R, Fabio, G, Faivre, L, Falck, A, Faure, M, Arquero, M, Ferrer, R, Ferreres, J, Francois, B, Fumado, V, Fung, K, Fusco, F, Gagro, A, Solis, B, Garcon, P, Gaussem, P, Gayretli, Z, Gil-Herrera, J, Gilardin, L, Gatineau, A, Girona-Alarcon, M, Cifuentes Godinez, K, Goffard, J, Gonzales, N, Gonzalez-Granado, L, Gonzalez-Montelongo, R, Guerder, A, Gulhan, B, Gumucio, V, Hanitsch, L, Gunst, J, Gut, M, Hadjadj, J, Hancerli, S, Hariyan, T, Hatipoglu, N, Heppekcan, D, Hernandez-Brito, E, Ho, P, Holanda-Pena, M, Horcajada, J, Hraiech, S, Humbert, L, Hung, I, Iglesias, A, Inigo-Campos, A, Jamme, M, Arranz, M, Jimeno, M, Jordan, I, Kanik-Yuksek, S, Kara, Y, Karahan, A, Karbuz, A, Yasar, K, Kasapcopur, O, Kashimada, K, Keles, S, Demirkol, Y, Kido, Y, Kizil, C, Kilic, A, Klocperk, A, Koutsoukou, A, Krol, Z, Ksouri, H, Kuentz, P, Kwan, A, Kwan, Y, Kwok, J, Lagier, J, Lam, D, Lampropoulou, V, Le Bourgeois, F, Leo, Y, Lopez, R, Leung, D, Levin, M, Levy, M, Levy, R, Li, Z, Lilleri, D, Adrian Bolanos Lima, E, Linglart, A, Lopez-Collazo, E, Lorenzo-Salazar, J, Louapre, C, Lubetzki, C, Lung, K, Luyt, C, Lye, D, Magnone, C, Marchioni, E, Marioli, C, Marjani, M, Marques, L, Pereira, J, Martin-Nalda, A, Pueyo, D, Martinez-Picado, J, Marzana, I, Mata-Martinez, C, Mathian, A, Matos, L, Matthews, G, Mayaux, J, McLaughlin-Garcia, R, Meersseman, P, Mege, J, Mekontso-Dessap, A, Melki, I, Meloni, F, Meritet, J, Merlani, P, Akcan, O, Mezidi, M, Migeotte, I, Millereux, M, Million, M, Mirault, T, Mircher, C, Mirsaeidi, M, Mizoguchi, Y, Modi, B, Mojoli, F, Moncomble, E, Melian, A, Martinez, A, Morandeira, F, Morange, P, Mordacq, C, Morelle, G, Munoz-Barrera, A, Nafati, C, Nagashima, S, Nakagama, Y, Neven, B, Neves, J, Ng, Y, Hubert, N, Medina, Y, Cuadros, E, Karabela, S, Ocejo-Vinyals, J, Oualha, M, Ouedrani, A, Ozkaya-Parlakay, A, Pagani, M, Papadaki, M, Parola, P, Pascreau, T, Paul, S, Paz-Artal, E, Pedraza, S, Gonzalez Pellecer, N, Pellegrini, S, Perez-Fernandez, X, Philippe, A, Philippot, Q, Picod, A, Pineton de Chambrun, M, Piralla, A, Planas-Serra, L, Ploin, D, Poissy, J, Poncelet, G, Poulakou, G, Pouletty, M, Pourshahnazari, P, Qiu-Chen, J, Quentric, P, Rambaud, T, Raoult, D, Raoult, V, Rebillat, A, Redin, C, Resmini, L, Ricart, P, Richard, J, Rigo-Bonnin, R, Rivet, N, Riviere, J, Rocamora-Blanch, G, Rodero, M, Rodrigo, C, Rodriguez, L, Rodriguez-Palmero, A, Romero, C, Rothenbuhler, A, Roux, D, Rovina, N, Rozenberg, F, Ruch, Y, Ruiz, M, Ruiz del 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- Abstract
Human genetic studies of critical COVID-19 pneumonia have revealed the essential role of type I interferon-dependent innate immunity to SARS-CoV-2 infection. Conversely, an association between the HLA-B∗15:01 allele and asymptomatic SARS-CoV-2 infection in unvaccinated individuals was recently reported, suggesting a contribution of pre-existing T cell-dependent adaptive immunity. We report a lack of association of classical HLA alleles, including HLA-B∗15:01, with pre-omicron asymptomatic SARS-CoV-2 infection in unvaccinated participants in a prospective population-based study in the United States (191 asymptomatic vs. 945 symptomatic COVID-19 cases). Moreover, we found no such association in the international COVID Human Genetic Effort cohort (206 asymptomatic vs. 574 mild or moderate COVID-19 cases and 1,625 severe or critical COVID-19 cases). Finally, in the Human Challenge Characterisation study, the three HLA-B∗15:01 individuals infected with SARS-CoV-2 developed symptoms. As with other acute primary infections studied, no classical HLA alleles favoring an asymptomatic course of SARS-CoV-2 infection were identified.
- Published
- 2024
3. Home-based exercise in autoimmune myasthenia gravis: A randomized controlled trial
- Author
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Azerad, Sylvie, Bassez, Guillaume, Behin, Anthony, Berrih-Aknin, Sonia, Bolgert, Francis, Ait-Younes, Nawal Derridj, Domingo, Yasmine, Frenkian, Mélinée, Friedman, Diane, Jobic, Asmaa, Laforêt, Pascal, Ledoux, Isabelle, Mendelson, Judith, Misdrahi, Sandra, Orblin Bedos, Cécilia, Rohaut, Benjamin, Ropers, Jacques, Soler, Elodie, Thoumie, Philippe, Truffault, Frédérique, Weiss, Nicolas, William, Linda, Birnbaum, S, Porcher, R, Portero, P, Clair, B, Demeret, S, Eymard, B, Gargiulo, M, Louët, E, Berrih-Aknin, S, Le Panse, R, Aegerter, P, Hogrel, JY, and Sharshar, T
- Published
- 2021
- Full Text
- View/download PDF
4. Effet de la combinaison thérapeutique abatacept–ruxolitinib et du dépistage de la défaillance respiratoire sur la mortalité de la myotoxicité induite par les inhibiteurs de des points de contrôle immunitaire
- Author
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Salem, J.E., primary, Bretagne, M., additional, Abbar, B., additional, Louis-Leonard, S., additional, Boussouar, S., additional, Demeret, S., additional, Procureur, A., additional, Dres, M., additional, Pineton De Chambrun, M., additional, Champtiaux, N., additional, Rigolet, A., additional, Wesner, N., additional, Anquetil, C., additional, Guillaume-Jugnot, P., additional, Weiss, N., additional, Benveniste, O., additional, Similowsky, T., additional, and Allenbach, Y., additional
- Published
- 2023
- Full Text
- View/download PDF
5. Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19
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B., Magazimama-Ext A., Maingret D., Mameri L., Manivet P., Mansouri C., Marcault E., Marey J., Marin N., Marois C., Martin O., Martineau L., Martinez-Lopez C., Martyniuck P., De Farcy P. M., Marzouk N., Masmoudi R., Mebazaa A., Mechai F., Mecozzi F., Mediouni C., Megarbane B., Meghadecha M., Mejean E., Mekinian A., Abdelhadi N. M., Mekni R., Meliti T. S., Lima B. M., Meng P., Merbah S., Messani F., Messaoudi Y., Mewasing B. -I., Meziane L., Michelot-Burger C., Mignot F., Minka F. H., Miyara M., Moine P., Molina J. -M., Montegnies-Boulet A., Monti A., Montlahuc C., Montout A. -L., Moores A., Morbieu C., Mortelette H., Mouly S., Muzaffar R., Nacerddine C. I., Nadal M., Nadif H., Nassarmadji K., Natella P., Ndingamondze S., Neraal S., Nguyen C., N'Guyen B., Larmurier I. N., Nlomenyengue L., Noel N., Nunes H., Omar E., Ouazene Z., Ouedraogo E., Ouelaa W., Oukhedouma A., Amara Y. 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S., Saliba F., Salmon D., Savale L., Savary G., Sberro R., Scemla A., Schlemmer F., Schwartz M., Sedfi S., Sefir-Kribel S., Seksik P., Sellier P., Selves A., Sembach N., Semerano L., Senat M. -V., Sene D., Serris A., Sese L., Sghiouar N., Sigaux J., Siguier M., Silvain J., Simon N., Simon T., Skandri L. I., Slimani M., Snauwaert A., Sokol H., Soliman H., Soltani N., Soyer B., Steg G., Suarez L., Szwebel T. -A., Taffame K., Tantet C., Tateo M., Theodose I., Thiebaud P., Thomas C., Tiercelet K., Tisserand J., Tomczak C., Torelino K., Touam-Ext F., Toumi L., Toury G., Toy-Miou M., Lien O. T. D. T., Trandinh A., Treluyer J. -M., Trinque B., Truchot J., Tunesi S., Turpin M., Turpin A., Urbina T., Narvaez R. U., Uzunhan Y., Vaittinadaayar P., Valent A., Valentian M., Valin N., Vallet H., Vaz M., Vazquezibarra M. -A., Vedie B., Velly L., Verstuyft C., Viallette C., Vicaut E., Vignes D., Vimpere D., Virlouvet M., Voiriot G., Voisot L., Weiss E., Weiss N., Winchenne A., Yordanov Y., Zafrani L., Zaidan M., Zaidi W., Zak C., Zarhrate-Ghoul A., Zatout O., Zeino S., Zeitouni M., Zemirli N., Zerah L., Zia O., Ziol M., Zolario O., Zuber J., Andrejak C., Angoulvant F., Bachelet D., Bartoli M., Basmaci R., Behilill S., Beluze M., Benkerrou D., Bhavsar K., Bouadma L., Bouchez S., Bouscambert M., Cervantes-Gonzalez M., Chair A., Coelho A., d'Ortenzio E., Debray M. -P., Deconinck L., Deplanque D., Descamps D., Desvallee M., Diallo A., Diouf A., Dorival C., Dubos F., Duval X., Elharrar B., Eloy P., Enouf V., Esperou H., Esposito-Farese M., Devouge E. F., Gault N., Gaymard A., Ghosn J., Gigante T., Gilg M., Guedj J., Hoctin A., Hoffmann I., Houas I., Hulot J. -S., Jaafoura S., Kaguelidou F., Kali S., Khalil A., Khan C., Laouenan C., Laribi S., Le M., Le Hingrat Q., Le Mestre S., Le Nagard H., Lescure F. -X., Levy Y., Lingas G., Lucet J. 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C., Casanova J. -L., Vacher Y., Gysembergh-Houal A., Demerville L., Chachoua A., Abad S., Abassi R., Abdellaoui A., Abdelmalek A., Abdoul H., Abergel H., Abeud F., Abgrall S., Abisror N., Adechian M., Aderdour N., Admane H. F., Adnet F., Afritt S., Agostini H., Aguilar C., Agut S., Aiello T. F., Kaci M. A., Oufella H. A., Ajeenthiravasan G., Alauzy V., Alby-Laurent F., Allard L., Alyanakian M. -A., Borrero B. A., Amam S., Amrouche L., Andronikof M., Anglicheau D., Anguel N., Annane D., Aounzou M., Aparicio C., Aratus G., Arlet J. -B., Arzoine J., Aslangul E., Assefi M., Aubry A., Audiffred L., Audureau E., Auger C. N., Auregan J. -C., Awotar C., Milla S. A., Azan D., Azemar L., Azzouguen B., Elrufaai M. B., Badsi A., Bakouboula P., Balcerowiak C., Balde F., Baldivia E., Bangamingo E. -F., Baptiste A., Baran-Marszak F., Barau C., Barget N., Baronnet F., Barthelemy R., Baudel J. -L., Baudry C., Baudry E., Beaugerie L., Belamri A., Belaube N., Belilita R., Bellassen P., Belmokhtar R., Beltran I., Benainous R., Benallaoua M., Benamouzig R., Benbara A., Benhida J., Benkhelouf A., Benlagha J., Benmostafa C., Benothmane S., Bentifraouine M., Berard L., Bernier Q., Berti E., Bertier A., Berton L., Bessis S., Beurton A., Bianco C., Bianquis C., Bidar F., Blanche P., Blayau C., Bleibtreu A., Blin E., Bloch-Queyrat C., Boissier M. -C., Bollens D., Bolzoni M., Bompard R., Bonnet N., Bonnouvrier J., Botha S., Boucenna W., Bouchama F., Bouchaud O., Bouchghoul H., Boudjebla T., Boudjema N., Bouffard C., Bougle A., Bouguerra M., Bouras L., Bourcier A., Durand A. B., Bourrier A., Bouscarat F., Bouvry D., Bouziri N., Bouzrara O., Bribier S., Brugier D., Brunel M., Bui E., Buisson A., Bukreyeva I., Bureau C., Cadranel J., Cailhol J., Calin R., Vega C. C., Canavaggio P., Cancella M., Cantin D., Cao A., Carbillon L., Carlier N., Cassard C., Castor G., Cauchy M., Cha O., Chaigne B., Challal S., Champion K., Chariot P., Chas J., Chauveau S., Chauvin A., Chauvin C., Chavarot N., Chebbout K., Cherai M., Cherubini I., Chevalier A., Chiarabini T., Chinet T., Chocron R., Choinier P., Chommeloux J., Choquet C., Choupeaux L., Chousterman B., Ciocan D., Clarke A., Clavere G., Clavier F., Clement K., Clerc S., Cohen Y., Cohen F., Cohen A., Coilly A., Colboc H., Colin P., Collet M., Comarmond C., Combacon E., Combes A., Comparon C., Constantin J. -M., Cordel H., Cordier A. -G., Costantini A., Chalumeau N. C., Couffignal C., Coupeau D., Creange A., Lamarre Y. C., Da Silveira C., Kayani S. D. G. 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S., Saliba F., Salmon D., Savale L., Savary G., Sberro R., Scemla A., Schlemmer F., Schwartz M., Sedfi S., Sefir-Kribel S., Seksik P., Sellier P., Selves A., Sembach N., Semerano L., Senat M. -V., Sene D., Serris A., Sese L., Sghiouar N., Sigaux J., Siguier M., Silvain J., Simon N., Simon T., Skandri L. I., Slimani M., Snauwaert A., Sokol H., Soliman H., Soltani N., Soyer B., Steg G., Suarez L., Szwebel T. -A., Taffame K., Tantet C., Tateo M., Theodose I., Thiebaud P., Thomas C., Tiercelet K., Tisserand J., Tomczak C., Torelino K., Touam-Ext F., Toumi L., Toury G., Toy-Miou M., Lien O. T. D. T., Trandinh A., Treluyer J. -M., Trinque B., Truchot J., Tunesi S., Turpin M., Turpin A., Urbina T., Narvaez R. U., Uzunhan Y., Vaittinadaayar P., Valent A., Valentian M., Valin N., Vallet H., Vaz M., Vazquezibarra M. -A., Vedie B., Velly L., Verstuyft C., Viallette C., Vicaut E., Vignes D., Vimpere D., Virlouvet M., Voiriot G., Voisot L., Weiss E., Weiss N., Winchenne A., Yordanov Y., Zafrani L., Zaidan M., Zaidi W., Zak C., Zarhrate-Ghoul A., Zatout O., Zeino S., Zeitouni M., Zemirli N., Zerah L., Zia O., Ziol M., Zolario O., Zuber J., Andrejak C., Angoulvant F., Bachelet D., Bartoli M., Basmaci R., Behilill S., Beluze M., Benkerrou D., Bhavsar K., Bouadma L., Bouchez S., Bouscambert M., Cervantes-Gonzalez M., Chair A., Coelho A., d'Ortenzio E., Debray M. -P., Deconinck L., Deplanque D., Descamps D., Desvallee M., Diallo A., Diouf A., Dorival C., Dubos F., Duval X., Elharrar B., Eloy P., Enouf V., Esperou H., Esposito-Farese M., Devouge E. F., Gault N., Gaymard A., Ghosn J., Gigante T., Gilg M., Guedj J., Hoctin A., Hoffmann I., Houas I., Hulot J. -S., Jaafoura S., Kaguelidou F., Kali S., Khalil A., Khan C., Laouenan C., Laribi S., Le M., Le Hingrat Q., Le Mestre S., Le Nagard H., Lescure F. -X., Levy Y., Lingas G., Lucet J. C., Malvy D., Mambert M., Meziane A., Mouquet H., Mullaert J., Neant N., Nguyen D., Noret M., Nseir S., Papadopoulos A., Paul C., Peiffer-Smadja N., Perpoint T., Petrov-Sanchez V., Peytavin G., Pham H., Picone O., Puechal O., Rabaud C., Rosa-Calatrava M., Rossignol B., Rossignol P., Roy C., Schneider M., Su R., Tardivon C., Tellier M. -C., Teoule F., Terrier O., Timsit J. -F., Tual C., Van Der Werf S., Vanel N., Veislinger A., Visseaux B., Wiedemann A., Yazdanpanah Y., Alavoine L., Behillil S., Burdet C., Charpentier C., Dechanet A., Ecobichon J. -L., Frezouls W., Houhou N., Lehacaut J., Letrou S., Lina B., Manchon P., Nouroudine M., Piquard V., Quintin C., Thy M., Vignali V., Chahine A., Waucquier N., Migaud M. -C., Djossou F., Mergeay-Fabre M., Lucarelli A., Demar M., Bruneau L., Gerardin P., Maillot A., Payet C., Laviolle B., Laine F., Paris C., Desille-Dugast M., Fouchard J., Pistone T., Perreau P., Gissot V., Goas C. L. E., Montagne S., Richard L., Chirouze C., Bouiller K., Desmarets M., Meunier A., Bourgeon M., Lefevre B., Jeulin H., Legrand K., Lomazzi S., Tardy B., Gagneux-Brunon A., Bertholon F., Botelho-Nevers E., Christelle K., Nicolas L., Roufai L., Amat K., Couffin-Cadiergues S., Hendou S., Foti G., Bellani G., Citerio G., Contro E., Pesci A., Valsecchi M. G., Cazzaniga M., Abad J., Accordino G., Achille C., Aguilera-Albesa S., Aguilo-Cucurull A., Ozkan E. A., Albisures J. A. R., Aldave J. C., Ramos M. A., Khan T. A., Aliberti A., Nadji S. A., Alkan G., AlKhater S. A., Allardet-Servent J., Alshahrani M. S., Alsina L., Amoura Z., Antoli A., Arrestier R., Aubart M., Auguet T., Avramenko I., Azot A., Bahram S., Bajolle F., Baldanti F., Baldolli A., Ballester M., Barrou B., Basso S., Bayhan G. I., Bezrodnik L., Bilbao A., Blanchard-Rohner G., Blanco I., Blandinieres A., Blazquez-Gamero D., Bloomfield M., Bolivar-Prados M., Borghesi A., Borie R., Botdhlo-Nevers E., Bousquet A., Boutolleau D., Bouvattier C., Boyarchuk O., Bravais J., Briones M. L., Brunner M. -E., Bruno R., Bueno M. R. P., Bukhari H., Bustamante J., Agra J. J. C., Capra R., Carapito R., Carrabba M., Casasnovas C., Caseris M., Cassaniti I., Castelle M., Castelli F., de Vera M. C., Castro M. V., Catherinot E., Celik J. B., Ceschi A., Chalumeau M., Charbit B., Cheng M. P., Clave P., Clotet B., Codina A., Comoli P., Corsico A. G., Sozeri B., Coskuner T., Cvetkovski A., Cyrus C., Dalmau D., Danion F., Darley D. R., Das V., Dauby N., Dauger S., De Munter P., de Pontual L., Dehban A., Delplancq G., Desguerre I., Di Sabatino A., Diehl J. -L., Dobbelaere S., Dominguez-Garrido E., Dubost C., Ekwall O., Bozdemir S. E., Elnagdy M. H., Emiroglu M., Endo A., Erdeniz E. H., Aytekin S. E., Lasa M. P. E., Euvrard R., Fabio G., Faivre L., Falck A., Faure M., Arquero M. F., Ferrer R., Ferreres J., Francois B., Fumado V., Fung K. S. C., Fusco F., Gagro A., Solis B. G., Garcon P., Gaussem P., Gayretli Z., Gil-Herrera J., Gilardin L., Gatineau A. G., Girona-Alarcon M., Godinez K. A. C., Goffard J. -C., Gonzales N., Gonzalez-Granado L. I., Gonzalez-Montelongo R., Guerder A., Gulhan B., Gumucio V. D., Hanitsch L. G., Gunst J., Hadjadj J., Hariyan T., Heppekcan D., Hernandez-Brito E., Ho P. -K., Holanda-Pena M. S., Horcajada J. P., Hraiech S., Humbert L., Hung I. F. N., Iglesias A. D., Inigo-Campos A., Jamme M., Arranz M. J., Jimeno M. -T., Jordan I., Yuksek S. K., Kara Y. B., Karahan A., Yasar K. K., Kasapcopur O., Kashimada K., Demirkol Y. K., Kido Y., Kizil C., Kilic A. O., Klocperk A., Koutsoukou A., Krol Z. J., Ksouri H., Kuentz P., Kwan A. M. C., Kwan Y. W. M., Kwok J. S. Y., Lagier J. -C., Lam D. S. Y., Lampropoulou V., Le Bourgeois F., Leo Y. -S., Leung D., Levin M., Levy M., Levy R., Li Z., Lilleri D., Lima E. J. A. B., Linglart A., Lopez-Collazo E., Lorenzo-Salazar J. M., Louapre C., Lubetzki C., Lung K. -C., Luyt C. -E., Lye D. C., Magnone C., Marchioni E., Marioli C., Marjani M., Marques L., Pereira J. M., Pueyo D. M., Marzana I., Mata-Martinez C., Mathian A., Matos L. R. B., Matthews G. V., Mayaux J., McLaughlin-Garcia R., Meersseman P., Mege J. -L., Mekontso-Dessap A., Melki I., Meloni F., Meritet J. -F., Merlani P., Akcan O. M., Mezidi M., Millereux M., Million M., Mirault T., Mircher C., Mirsaeidi M., Mizoguchi Y., Modi B. P., Mojoli F., Moncomble E., Melian A. M., Martinez A. M., Morandeira F., Mordacq C., Mouly S. J., Munoz-Barrera A., Nafati C., Nagashima S., Nakagama Y., Neven B., Neves J. F., Ng Y. -Y., Nielly H., Medina Y. N., Cuadros E. N., Ocejo-Vinyals J. G., Okamoto K., Oualha M., Ouedrani A., Ozcelik T., Ozkaya-Parlakay A., Pagani M., Papadaki M., Parola P., Pascreau T., Paul S., Paz-Artal E., Pedraza S., Pellecer N. C. G., Pellegrini S., Perez-Fernandez X. L., Philippe A., Philippot Q., Picod A., Piralla A., Ploin D., Poissy J., Poncelet G., Poulakou G., Pouletty M. S., Pourshahnazari P., Qiu-Chen J. L., Quentric P., Rambaud T., Raoult D., Raoult V., Rebillat A. -S., Redin C., Resmini L., Ricart P., Richard J. -C., Rigo-Bonnin R., rivet N., Rocamora-Blanch G., Rodero M. P., Rodrigo C., Rodriguez L. A., Rodriguez-Palmero A., Romero C. S., Rothenbuhler A., Roux D., Rovina N., Rozenberg F., Ruch Y., Ruiz M., del Prado M. Y. R., Ruiz-Rodriguez J. C., Sabater-Riera J., Saks K., Salagianni M., Sanchez O., Sanchez-Montalva A., Sanchez-Ramon S., Schidlowski L., Schmidt J., Schmidt M., Schuetz C., Schweitzer C. E., Scolari F., Seijo L., Seminario A. G., Seng P., Senoglu S., Seppanen M., Llovich A. S., Siguret V., Siouti E., Smadja D. M., Smith N., Solanich X., Sole-Violan J., Soler C., Stella G. M., Stepanovskiy Y., Stoclin A., Taccone F., Taupin J. -L., Tavernier S. J., Tello L. V., Terrier B., Thiery G., Thorball C., Thorn K., Thumerelle C., Tolstrup M., Tomasoni G., Toubiana J., Alvarez J. T., Triantafyllia V., Trouillet-Assant S., Tsang O. T. Y., Tserel L., Tso E. Y. K., Tucci A., Oz S. K. T., Ursini M. V., Utsumi T., Vabres P., Valencia-Ramos J., Van Den Rym A. M., Vandernoot I., Velez-Santamaria V., Veliz S. P. Z., Vidigal M. C., Viel S., Villain C., Vilaire-Meunier M. E., Villar-Garcia J., Vincent A., Volokha A., Vuotto F., Wauters E., Wauters J., Wu A. K. L., Wu T. -C., Yahsi A., Yesilbas O., Yildiz M., Young B. E., Yukselmis U., Zecca M., Zuccaro V., Van Praet J., Lambrecht B. N., Van Braeckel E., Bosteels C., Hoste L., Hoste E., Bauters F., De Clercq J., Heijmans C., Slabbynck H., Naesens L., Florkin B., Boulanger C., Vanderlinden D., Berkell M., Carelli V., Malhotra S., Mattiaccio A., Pippucci T., Seri M., Tacconelli E., van Agtmael M., Algera A. G., Appelman B., van Baarle F., Bax D., Beudel M., Bogaard H. J., Bomers M., Bonta P., Bos L., Botta M., de Brabander J., de Bree G., de Bruin S., Buis D. T. P., Bugiani M., Bulle E., Cloherty O. C. A., Dijkstra M., Dongelmans D. A., Dujardin R. W. G., Elbers P., Fleuren L., Geijtenbeek S. G. T., Girbes A., Goorhuis B., Grobusch M. P., Hafkamp F., Hagens L., Hamann J., Harris V., Hemke R., Heunks S. M. H. L., Hollmann M., Horn J., Hovius J. W., de Jong M. D., Koning R., Lim E. H. T., van Mourik N., Nellen J., Nossent E. J., Paulus F., Peters E., Pina-Fuentes D. A. I., van der Poll T., Preckel B., Prins J. M., Raasveld J., Reijnders T., de Rotte M. C. F. J., Schinkel M., Schultz M. J., Schrauwen F. A. P., Schuurmans A., Schuurmans J., Sigaloff K., Slim M. A., Smeele P., Smit M., Stijnis C. S., Stilma W., Teunissen C., Thoral P., Tsonas A. M., Tuinman P. R., van der Valk M., Veelo D., Volleman C., de Vries H., Vught L. A., van Vugt M., Wouters D., Zwinderman A. H., Brouwer M. C., Wiersinga W. J., Vlaar A. P. J., Tompkins M. F., Alba C., Hupalo D. N., Rosenberger J., Sukumar G., Wilkerson M. D., Zhang X., Lack J., Oler A. J., Dobbs K., Danielson J. J., Biondi A., Bettini L. R., D'Angio' M., Beretta I., Imberti L., Sottini A., Quaresima V., Quiros-Roldan E., Rossi C., Meyts I., Zhang S. -Y., Puel A., Notarangelo L. D., Boisson-Dupuis S., Su H. C., Boisson B., Jouanguy E., Zhang Q., Abel L., and Cobat A.
- Abstract
Background: We previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15–20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in ~ 80% of cases. Methods: We report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded. Results: No gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5–528.7, P = 1.1 × 10−4) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR = 3.70[95%CI 1.3–8.2], P = 2.1 × 10−4). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR = 19.65[95%CI 2.1–2635.4], P = 3.4 × 10−3), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR = 4.40[9%CI 2.3–8.4], P = 7.7 × 10−8). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD] = 43.3 [20.3] years) than the other patients (56.0 [17.3] years; P = 1.68 × 10−5). Conclusions: Rare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old.
- Published
- 2023
6. Functional outcomes in adult patients with herpes simplex encephalitis admitted to the ICU: a multicenter cohort study
- Author
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Jaquet, P., de Montmollin, E., Dupuis, C., Sazio, C., Conrad, M., Susset, V., and Demeret, S.
- Subjects
Medical research ,Medicine, Experimental ,Herpes simplex -- Patient outcomes ,Herpes simplex encephalitis -- Patient outcomes ,Health care industry - Abstract
Purpose We aimed to study the association of body temperature and other admission factors with outcomes of herpes simplex encephalitis (HSE) adult patients requiring ICU admission. Methods We conducted a retrospective multicenter study on patients diagnosed with HSE in 47 ICUs in France, between 2007 and 2017. Fever was defined as a body temperature higher or equal to 38.3 °C. Multivariate logistic regression analysis was used to identify factors associated with poor outcome at 90 days, defined by a score of 3-6 (indicating moderate-to-severe disability or death) on the modified Rankin scale. Results Overall, 259 patients with a score on the Glasgow coma scale of 9 (6-12) and a body temperature of 38.7 (38.1-39.2) °C at admission were studied. At 90 days, 185 (71%) patients had a poor outcome, including 44 (17%) deaths. After adjusting for age, fever (OR = 2.21; 95% CI 1.18-4.16), mechanical ventilation (OR = 2.21; 95% CI 1.21-4.03), and MRI brain lesions > 3 lobes (OR = 3.04; 95% CI 1.35-6.81) were independently associated with poor outcome. By contrast, a direct ICU admission, as compared to initial admission to the hospital wards (i.e., indirect ICU admission), was protective (OR = 0.52; 95% CI 0.28-0.95). Sensitivity analyses performed after adjustment for functional status before admission and reason for ICU admission yielded similar results. Conclusions In HSE adult patients requiring ICU admission, several admission factors are associated with an increased risk of poor functional outcome. The identification of potentially modifiable factors, namely, elevated admission body temperature and indirect ICU admission, provides an opportunity for testing further intervention strategies., Author(s): P. Jaquet [sup.1], E. de Montmollin [sup.1] [sup.2], C. Dupuis [sup.1] [sup.2], C. Sazio [sup.3], M. Conrad [sup.4], V. Susset [sup.5], S. Demeret [sup.6], J. M. Tadie [sup.7], L. [...]
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- 2019
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7. Bedside video-oculography to assess the caloric vestibulo-ocular reflex in ICU patients, a preliminary study
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Marois, C., primary, Quirins, M., additional, Seassau, M., additional, Demeret, S., additional, Demoule, A., additional, Naccache, L., additional, and Weiss, N., additional
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- 2023
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8. Alteration of cerebral perfusion as a cause of cerebral complications associated with sepsis
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Gaspard, Nicolas, Taccone, Fabio, Lybaert, Pascale, De Backer, Daniel, Piagnerelli, Michaël, Schultz, Joachim, Osseman, Michel, Demeret, S., Ferlini, Lorenzo, Gaspard, Nicolas, Taccone, Fabio, Lybaert, Pascale, De Backer, Daniel, Piagnerelli, Michaël, Schultz, Joachim, Osseman, Michel, Demeret, S., and Ferlini, Lorenzo
- Abstract
Sepsis-induced impairment of cerebral function is the result of the interaction of multiples factors.The findings of our studies show that the alteration in perfusion potentially plays a role in SAE dueto a disruption of the mechanisms of CBF regulation that negatively influence cortical function. Thealteration of these protective mechanisms is a dynamic process. We showed that CA becomesimpaired only in the late phases of sepsis and this in odds with previous literature. Therefore, in aclinical scenario, patients frequently present a shifted CA curve, due to other medical preexistingconditions, preventing a correct interpretation of CA parameters. Since methods to monitor CA inreal time are increasingly available, prospective randomized trials should be underwent to answer thequestion of whether individualizing perfusion pressure targets in septic patients has a positive effectover outcome. Some studies suggested that NVC might be less robust against a sepsis-inducedinflammation challenge. Accordingly, we showed that, already in early phases of sepsis, NVCbecomes less performant to sustain the seizure-induced increase in neuronal activity. Furthermore, inhealthy animals, recurring seizure might independently alter the control mechanisms of cerebralperfusion which become inadequate to balance the enormous metabolic needs of rapidly firingneurons resulting in a reduction in inter-ictal tissue oxygenation. Thus, the association of seizure andsepsis may be particularly dangerous in those patients presenting a prior condition known to alterNVC (such as subarachnoid haemorrhage, traumatic brain injury or ischemic stroke). We showed inour animal model that systemic inflammation does not trigger spontaneous seizures in a healthy brain.This finding was confirmed by clinical data of our highly selected patient cohort, since we do notrecord any spontaneous seizure. Sepsis won’t be a risk factor for seizure occurrence per se but,reducing seizure threshold, it may elicit them i, Doctorat en Sciences médicales (Médecine), info:eu-repo/semantics/nonPublished
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- 2023
9. Clinical features, etiologies, and outcomes in adult patients with meningoencephalitis requiring intensive care (EURECA): an international prospective multicenter cohort study
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Sonneville, R, de Montmollin, E, Contou, D, Ferrer, R, Gurjar, M, Klouche, K, Sarton, B, Demeret, S, Bailly, P, da Silva, D, Escudier, E, Le Guennec, L, Chabanne, R, Argaud, L, Ben Hadj Salem, O, Thyrault, M, Frerou, A, Louis, G, De Pascale, G, Horn, J, Helbok, R, Geri, G, Bruneel, F, Martin-Loeches, I, Taccone, F, De Waele, J, Ruckly, S, Staiquly, Q, Citerio, G, Timsit, J, Sonneville, Romain, de Montmollin, Etienne, Contou, Damien, Ferrer, Ricard, Gurjar, Mohan, Klouche, Kada, Sarton, Benjamine, Demeret, Sophie, Bailly, Pierre, da Silva, Daniel, Escudier, Etienne, Le Guennec, Loic, Chabanne, Russel, Argaud, Laurent, Ben Hadj Salem, Omar, Thyrault, Martial, Frerou, Aurélien, Louis, Guillaume, De Pascale, Gennaro, Horn, Janneke, Helbok, Raimund, Geri, Guillaume, Bruneel, Fabrice, Martin-Loeches, Ignacio, Taccone, Fabio Silvio, De Waele, Jan J, Ruckly, Stéphane, Staiquly, Quentin, Citerio, Giuseppe, Timsit, Jean-François, Sonneville, R, de Montmollin, E, Contou, D, Ferrer, R, Gurjar, M, Klouche, K, Sarton, B, Demeret, S, Bailly, P, da Silva, D, Escudier, E, Le Guennec, L, Chabanne, R, Argaud, L, Ben Hadj Salem, O, Thyrault, M, Frerou, A, Louis, G, De Pascale, G, Horn, J, Helbok, R, Geri, G, Bruneel, F, Martin-Loeches, I, Taccone, F, De Waele, J, Ruckly, S, Staiquly, Q, Citerio, G, Timsit, J, Sonneville, Romain, de Montmollin, Etienne, Contou, Damien, Ferrer, Ricard, Gurjar, Mohan, Klouche, Kada, Sarton, Benjamine, Demeret, Sophie, Bailly, Pierre, da Silva, Daniel, Escudier, Etienne, Le Guennec, Loic, Chabanne, Russel, Argaud, Laurent, Ben Hadj Salem, Omar, Thyrault, Martial, Frerou, Aurélien, Louis, Guillaume, De Pascale, Gennaro, Horn, Janneke, Helbok, Raimund, Geri, Guillaume, Bruneel, Fabrice, Martin-Loeches, Ignacio, Taccone, Fabio Silvio, De Waele, Jan J, Ruckly, Stéphane, Staiquly, Quentin, Citerio, Giuseppe, and Timsit, Jean-François
- Abstract
Purpose: We aimed to characterize the outcomes of patients with severe meningoencephalitis requiring intensive care. Methods: We conducted a prospective multicenter international cohort study (2017–2020) in 68 centers across 7 countries. Eligible patients were adults admitted to the intensive care unit (ICU) with meningoencephalitis, defined by an acute onset of encephalopathy (Glasgow coma scale (GCS) score ≤ 13), a cerebrospinal fluid pleocytosis ≥ 5 cells/mm3, and at least two of the following criteria: fever, seizures, focal neurological deficit, abnormal neuroimaging, and/or electroencephalogram. The primary endpoint was poor functional outcome at 3 months, defined by a score of three to six on the modified Rankin scale. Multivariable analyses stratified on centers investigated ICU admission variables associated with the primary endpoint. Results: Among 599 patients enrolled, 589 (98.3%) completed the 3-month follow-up and were included. Overall, 591 etiologies were identified in those patients which were categorized into five groups: acute bacterial meningitis (n = 247, 41.9%); infectious encephalitis of viral, subacute bacterial, or fungal/parasitic origin (n = 140, 23.7%); autoimmune encephalitis (n = 38, 6.4%); neoplastic/toxic encephalitis (n = 11, 1.9%); and encephalitis of unknown origin (n = 155, 26.2%). Overall, 298 patients (50.5%, 95% CI 46.6–54.6%) had a poor functional outcome, including 152 deaths (25.8%). Variables independently associated with a poor functional outcome were age > 60 years (OR 1.75, 95% CI 1.22–2.51), immunodepression (OR 1.98, 95% CI 1.27–3.08), time between hospital and ICU admission > 1 day (OR 2.02, 95% CI 1.44–2.99), a motor component on the GCS ≤ 3 (OR 2.23, 95% CI 1.49–3.45), hemiparesis/hemiplegia (OR 2.48, 95% CI 1.47–4.18), respiratory failure (OR 1.76, 95% CI 1.05–2.94), and cardiovascular failure (OR 1.72, 95% CI 1.07–2.75). In contrast, administration of a third-generation cephalosporin (OR 0.54, 95% CI 0.37–0.
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- 2023
10. Intoxication aiguë par le mercure : intérêt des dosages capillaires
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Djebrani-Oussedik, N., Marois, C., Devianne, J., Demeret, S., Langrand, J., Labat, L., and Poupon, J.
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- 2024
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11. Correction to: Functional outcomes in adult patients with herpes simplex encephalitis admitted to the ICU: a multicenter cohort study
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Jaquet, P., de Montmollin, E., Dupuis, C., Sazio, C., Conrad, M., Susset, V., Demeret, S., Tadie, J. M., Argaud, L., Barbier, F., Sarton, B., Chabane, R., Daubin, D., Brulé, N., Lerolle, N., Alves, M., Da Silva, D., Kalioubi, A. El, Silva, S., Bailly, P., Wolff, M., Bouadma, L., Timsit, J. F., Sonneville, R., and ENCEPHALITICA study group
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- 2019
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12. Syndrome de Guillain-Barré : physiopathologie et aspects diagnostiques
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Carpentier, V.T., primary, Le Guennec, L., additional, Fall, S.A.A., additional, Viala, K., additional, Demeret, S., additional, and Weiss, N., additional
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- 2022
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13. Les maladies neuromusculaires aiguës
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Duguet, A., Rabbat, A., Demeret, S., and Le Floch, H.
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- 2012
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14. Vers de nouvelles recommandations françaises sur la prise en charge des états de mal épileptiques
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Navarro, V., Demeret, S., and Outin, H.
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- 2016
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15. Toxic-metabolic encephalopathy in adults: Critical discussion and pragmatical diagnostic approach
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Le Guennec, L., primary, Marois, C., additional, Demeret, S., additional, Wijdicks, E.F.M., additional, and Weiss, N., additional
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- 2022
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16. Shaping the future of neurocritical care in France
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Rohaut, B., primary and Demeret, S., additional
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- 2022
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17. Axonal Guillain‐Barré syndrome and toxic epidermal necrolysis: two cases
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Weill, A., primary, Demeret, S., additional, Ingen‐Housz‐Oro, S., additional, Colin, A., additional, Bagate, F., additional, de Prost, N., additional, and Weiss, N., additional
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- 2021
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18. Myotoxicité liée aux inhibiteurs de points de contrôle immunitaire: trouble de l’appareil musculaire et/ou de la jonction neuromusculaire?
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Chassepot, H., primary, Plomp, L., additional, Mensi, S., additional, Psimaras, D., additional, Touat, M., additional, Alyanakian, M.A., additional, Louis-Leonard, S., additional, Plu, I., additional, Maisonobe, T., additional, Anquetil, C., additional, Wesner, N., additional, Champtiaux, N., additional, Rigolet, A., additional, Demeret, S., additional, Weiss, N., additional, Pinna, B., additional, Bretagne, M.C., additional, Salem, J.E., additional, Benveniste, O., additional, and Allenbach, Y., additional
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- 2021
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19. Prise en charge de l’état de mal tonicoclonique généralisé : stratégies thérapeutiques
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Clair, B., Demeret, S., Dupont, S., and Tazarourte, K.
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- 2009
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20. Prise en charge non spécifique de l’état de mal épileptique convulsif
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Engrand, N., Demeret, S., Savary, D., and Clair, B.
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- 2009
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21. Champ 7 - prise en charge de l’état de mal tonicoclonique généralisé : stratégies thérapeutiques
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Clair, B., Demeret, S., Dupont, S., and Tazarourte, K.
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- 2009
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22. Champ 5 – Prise en charge non specifique de l’état de mal convulsif
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Engrand, N., Demeret, S., Savary, D., and Clair, B.
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- 2009
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23. Le FOUR score en français, un nouveau score d’évaluation de la profondeur du coma
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Weiss, N., Mutlu, G., Essardy, F., Nacabal, C., Sauves, C., Bally, C., Houbert, M., Lecorre, C., Germack, V., Demeret, S., Pierrot-Deseilligny, C., and Bolgert, F.
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- 2009
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24. Home-based exercise in autoimmune myasthenia gravis: A randomized controlled trial
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Birnbaum, S, primary, Porcher, R, additional, Portero, P, additional, Clair, B, additional, Demeret, S, additional, Eymard, B, additional, Gargiulo, M, additional, Louët, E, additional, Berrih-Aknin, S, additional, Le Panse, R, additional, Aegerter, P, additional, Hogrel, JY, additional, Sharshar, T, additional, Azerad, Sylvie, additional, Bassez, Guillaume, additional, Behin, Anthony, additional, Berrih-Aknin, Sonia, additional, Bolgert, Francis, additional, Ait-Younes, Nawal Derridj, additional, Domingo, Yasmine, additional, Frenkian, Mélinée, additional, Friedman, Diane, additional, Jobic, Asmaa, additional, Laforêt, Pascal, additional, Ledoux, Isabelle, additional, Mendelson, Judith, additional, Misdrahi, Sandra, additional, Orblin Bedos, Cécilia, additional, Rohaut, Benjamin, additional, Ropers, Jacques, additional, Soler, Elodie, additional, Thoumie, Philippe, additional, Truffault, Frédérique, additional, Weiss, Nicolas, additional, and William, Linda, additional
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- 2021
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25. Encéphalites auto-immunes à anticorps antirécepteurs-NMDA, une cause fréquente d’encéphalite en réanimation
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Lamarque, M., Psimaras, D., Ducray, F., Pelieu, I., Sonneville, R., Demeret, S., Bolgert, F., Dehais, C., Camdessanche, J. -P., Antoine, J. -C., Honnorat, J., Delattre, J. -Y., and Weiss, N.
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- 2011
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26. Dysimmunité paranéoplasique dans les tumeurs à cellules dendritiques folliculaires : au-delà du syndrome auto-immun multi-organe paranéoplasique
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Coignard, E., primary, Lepelletier, C., additional, Frumholtz, L., additional, Boutboul, D., additional, Galicier, L., additional, Lazaridou, I., additional, Jachiet, M., additional, Demeret, S., additional, Maisonobe, T., additional, Psimaras, D., additional, Bagot, M., additional, Bouaziz, J.-D., additional, and Cassius, C., additional
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- 2020
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27. Axonal Guillain‐Barré syndrome and toxic epidermal necrolysis: two cases.
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Weill, A., Demeret, S., Ingen‐Housz‐Oro, S., Colin, A., Bagate, F., de Prost, N., and Weiss, N.
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TOXIC epidermal necrolysis , *GUILLAIN-Barre syndrome , *NEUROMUSCULAR diseases , *CENTRAL nervous system , *NERVOUS system , *MEDICAL research - Abstract
CNS involvement is not described in AMSAN even if the Bickerstaff brainstem encephalitis, a rare form of GBS with CNS involvement, is supposed to be pathophysiologicaly very close to AMAN.7 In our two cases, the brain damage was more likely related to confounding factors due to prolonged critical care stay. A 43- (patient 1) and a 42- (patient 2) year-old men were admitted in the ICU for TEN induced by lamotrigine and allopurinol, respectively. Patient 1 presented a massive pulmonary embolism, which required surgical embolectomy and extracorporeal circulatory assistance; patient 2 developed multiple septic episodes and hyperthermia up to 42°C for 48 h (Table 1). [Extracted from the article]
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- 2022
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28. Concurrent excitatory and inhibitory effects of high frequency stimulation: an oculomotor study. (Paper)
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Bejjani, B-P., Arnulf, I., Houeto, J-L., Milea, D., Demeret, S., Pidoux, B., Damier, P., Cornu, P., Dormont, D., and Agid, Y.
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Electric stimulation ,Parkinson's disease -- Care and treatment -- Complications and side effects ,Health ,Psychology and mental health ,Care and treatment ,Complications and side effects - Abstract
Objective: To describe a reversible neurological condition resembling a crossed midbrain syndrome resulting from high frequency stimulation (HFS) in the midbrain. Methods: Postoperative evaluation of quadripolar electrodes implanted in the [...]
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- 2002
29. Encéphalopathies liées au COVID-19 : apport de la TEP-FDG cérébrale dans une série de 4 cas
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Delorme, C., primary, Paccoud, O., additional, Kas, A., additional, Hesters, A., additional, Bombois, S., additional, Maatoug, R., additional, Navarro, V., additional, Bruneteau, G., additional, Demeret, S., additional, and Pourcher, V., additional
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- 2020
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30. Recommandations Formalisées d’Experts SRLF/SFMU : Prise en charge des états de mal épileptiques en préhospitalier, en structure d’urgence et en réanimation dans les 48 premières heures (A l’exclusion du nouveau-né et du nourrisson)
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Outin, H., primary, Gueye, P., additional, Alvarez, V., additional, Auvin, S., additional, Clair, B., additional, Convers, P., additional, Crespel, A., additional, Demeret, S., additional, Dupont, S., additional, Engels, J.-C., additional, Engrand, N., additional, Freund, Y., additional, Gelisse, P., additional, Girot, M., additional, Marcoux, M.-O., additional, Navarro, V., additional, Rossetti, A., additional, Santoli, F., additional, Sonneville, R., additional, Szurhaj, W., additional, Thomas, P., additional, Titomanlio, L., additional, Villega, F., additional, Lefort, H., additional, and Peigne, V., additional
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- 2020
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31. PROMINENT PLASMACYTOSIS FOLLOWING INTRAVENOUS IMMUNOGLOBULIN PREDICTS FASTER CLINICAL IMPROVEMENT IN GUILLAIN-BARRé SYNDROME
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Mori, I, Parizot, C, Dorgham, K, Demeret, S, Amoura, Z, Bolgert, F, Debre, P, and Gorochov, G
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- 2008
32. TWO PATIENTS WITH CIDP DETERIORATED FOLLOWING PLASMA EXCHANGE
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Larue, S, Dashi, F, Demeret, S, Bolgert, F, Viala, K, and Léger, J-M
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- 2008
33. Vivid dreams, hallucinations, psychosis and REM sleep in Guillain–Barré syndrome
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Cochen, V., Arnulf, I., Demeret, S., Neulat, M. L., Gourlet, V., Drouot, X., Moutereau, S., Derenne, J. P., Similowski, T., Willer, J. C., Pierrot-Deseiligny, C., and Bolgert, F.
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- 2005
34. Physiopathologie de la Sclérose Latérale Amyotrophique : approches thérapeutiques
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Bruneteau, G., Demeret, S., and Meininger, V.
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- 2004
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35. Decisional role of the dorsolateral prefrontal cortex in ocular motor behaviour
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Pierrot-Deseilligny, C., Müri, R. M., Ploner, C. J., Gaymard, B., Demeret, S., and Rivaud-Pechoux, S.
- Published
- 2003
36. Proposed consensus definitions for new-onset refractory status epilepticus (NORSE), febrile infection-related epilepsy syndrome (FIRES), and related conditions
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Hirsch, L.J., Gaspard, Nicolas, van Baalen, Andreas, Nabbout, R., Demeret, S., Loddenkemper, Tobias, Navarro, V., Specchio, Nicola, Lagae, Lieven, Rossetti, Andrea A.O., Hocker, S., Gofton, Teneille, Abend, N.S., Gilmore, Emily E.J., Hahn, C., Khosravani, H., Rosenow, F., Trinka, E., Hirsch, L.J., Gaspard, Nicolas, van Baalen, Andreas, Nabbout, R., Demeret, S., Loddenkemper, Tobias, Navarro, V., Specchio, Nicola, Lagae, Lieven, Rossetti, Andrea A.O., Hocker, S., Gofton, Teneille, Abend, N.S., Gilmore, Emily E.J., Hahn, C., Khosravani, H., Rosenow, F., and Trinka, E.
- Abstract
We convened an international group of experts to standardize definitions of New-Onset Refractory Status Epilepticus (NORSE), Febrile Infection-Related Epilepsy Syndrome (FIRES), and related conditions. This was done to enable improved communication for investigators, physicians, families, patients, and other caregivers. Consensus definitions were achieved via email messages, phone calls, an in-person consensus conference, and collaborative manuscript preparation. Panel members were from 8 countries and included adult and pediatric experts in epilepsy, electroencephalography (EEG), and neurocritical care. The proposed consensus definitions are as follows: NORSE is a clinical presentation, not a specific diagnosis, in a patient without active epilepsy or other preexisting relevant neurological disorder, with new onset of refractory status epilepticus without a clear acute or active structural, toxic or metabolic cause. FIRES is a subcategory of NORSE, applicable for all ages, that requires a prior febrile infection starting between 2 weeks and 24 hours prior to onset of refractory status epilepticus, with or without fever at onset of status epilepticus. Proposed consensus definitions are also provided for Infantile Hemiconvulsion-Hemiplegia and Epilepsy syndrome (IHHE) and for prolonged, refractory and super-refractory status epilepticus. This document has been endorsed by the Critical Care EEG Monitoring Research Consortium. We hope these consensus definitions will promote improved communication, permit multicenter research, and ultimately improve understanding and treatment of these conditions., SCOPUS: re.j, info:eu-repo/semantics/published
- Published
- 2018
37. COVID‐19‐related encephalopathy: a case series with brain FDG‐positron‐emission tomography/computed tomography findings.
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Delorme, C., Paccoud, O., Kas, A., Hesters, A., Bombois, S., Shambrook, P., Boullet, A., Doukhi, D., Le Guennec, L., Godefroy, N., Maatoug, R., Fossati, P., Millet, B., Navarro, V., Bruneteau, G., Demeret, S., and Pourcher, V.
- Subjects
BRAIN tomography ,MYOCLONUS ,FRONTAL lobe diseases ,COVID-19 ,COGNITION disorders ,CEREBROSPINAL fluid ,SYMPTOMS - Abstract
Aim: The aim of this paper is to describe the clinical features of COVID‐19‐related encephalopathy and their metabolic correlates using brain 2‐desoxy‐2‐fluoro‐D‐glucose (FDG)‐positron‐emission tomography (PET)/computed tomography (CT) imaging. Background and purpose: A variety of neurological manifestations have been reported in association with COVID‐19. COVID‐19‐related encephalopathy has seldom been reported and studied. Methods: We report four cases of COVID‐19‐related encephalopathy. The diagnosis was made in patients with confirmed COVID‐19 who presented with new‐onset cognitive disturbances, central focal neurological signs, or seizures. All patients underwent cognitive screening, brain magnetic resonance imaging (MRI), lumbar puncture, and brain 2‐desoxy‐2‐fluoro‐D‐glucose (FDG)‐positron‐emission tomography (PET)/computed tomography (CT) (FDG‐PET/CT). Results: The four patients were aged 60 years or older, and presented with various degrees of cognitive impairment, with predominant frontal lobe impairment. Two patients presented with cerebellar syndrome, one patient had myoclonus, one had psychiatric manifestations, and one had status epilepticus. The delay between first COVID‐19 symptoms and onset of neurological symptoms was between 0 and 12 days. None of the patients had MRI features of encephalitis nor significant cerebrospinal fluid (CSF) abnormalities. SARS‐CoV‐2 RT‐PCR in the CSF was negative for all patients. All patients presented with a consistent brain FDG‐PET/CT pattern of abnormalities, namely frontal hypometabolism and cerebellar hypermetabolism. All patients improved after immunotherapy. Conclusions: Despite varied clinical presentations, all patients presented with a consistent FDG‐PET pattern, which may reflect an immune mechanism. [ABSTRACT FROM AUTHOR]
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- 2020
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38. Toxocara canis meningomyelitis
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Dauriac–Le Masson, V., Chochon, F., Demeret, S., and Pierrot–Deseilligny, C.
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- 2005
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39. Crise myasthénique chez le sujet de plus de 70 ans : quel pronostic après la réanimation ?
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Weiss, N., Demeret, S., Wegener, K., Pierrot-Deseilligny, C., and Bolgert, F.
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- 2009
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40. Posterior reversible encephalopathy syndrome (PRES) and hypomagnesemia: A frequent association?
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Chardain, A., Mesnage, V., Alamowitch, S., Bourdain, F., Crozier, S., Lenglet, T., Psimaras, D., Demeret, S., Graveleau, P., Hoang-Xuan, K., and Levy, R.
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- 2016
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41. CONGENITAL MYASTHENIC SYNDROMES AND MYASTHENIA
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Louet, E., primary, Misdrahi, S., additional, Bedos, C. Orblin, additional, Birnbaum, S., additional, Hogrel, JR., additional, Portero, P., additional, Clair, B., additional, Eymard, B., additional, Demeret, S., additional, Bassez, G., additional, Berrih-Aknin, S., additional, Jobic, A., additional, Aegerter, P., additional, Thoumie, P., additional, Sharshar, T., additional, and Gargiulo, M., additional
- Published
- 2018
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42. Decisional role of the dorsolateral prefrontal cortex in ocular motor behaviour
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Pierrot‐Deseilligny, C., Müri, R. M., Ploner, C. J., Gaymard, B., Demeret, S., Rivaud‐Pechoux, S., Pierrot‐Deseilligny, C., Müri, R. M., Ploner, C. J., Gaymard, B., Demeret, S., and Rivaud‐Pechoux, S.
- Abstract
Three patients with a unilateral cortical lesion affecting the dorsolateral prefrontal cortex (DLPFC), i.e. Brodmann area 46, were tested using different paradigms of reflexive saccades (gap and overlap tasks), intentional saccades (antisaccades, memory‐guided and predictive saccades) and smooth pursuit movements. Visually guided saccades with gap and overlap, latency of correct antisaccades and memory‐guided saccades and the gain of smooth pursuit were normal, compared with controls. These results confirm our anatomical data showing that the adjacent frontal eye field (FEF) was unimpaired in these patients. The specific pattern of abnormalities after a unilateral DLPFC lesion, compared with that of the FEF lesions previously reported, consists mainly of: (i) a bilateral increase in the percentage of errors in the antisaccade task (misdirected reflexive saccades); (ii) a bilateral increase in the variable error in amplitude, without significant decrease in the gain, in the memory‐guided saccade task; and (iii) a bilateral decrease in the percentage of anticipatory saccades in the predictive task. Taken together, these results suggest that the DLPFC plays a crucial role in the decisional processes, preparing saccades by inhibiting unwanted reflexive saccades (inhibition), maintaining memorized information for ongoing intentional saccades (short‐term spatial memory) or facilitating anticipatory saccades (prediction), depending upon current external environmental and internal circumstances
- Published
- 2017
43. French Intensive Care Society, International congress - Réanimation 2016
- Author
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Serroukh, Y, Boudjeltia, K, Joosten, A, Rousseau, A, Delabranche, X, Grunebaum, L, Mootien, Y, Gaci, R, Garric, J, Delbove, A, Darreau, C, Dargent, A, Soudry Faure, A, De Chambrun, M, Demondion, P, Blanchard, J, Chocron, S, Meneveau, N, Corsi, F, Meynieu, P, Repusseau, B, Germain, A, Baudry, G, Hierle, L, Besch, G, Thomas, G, Cassir, N, Dizier, S, Roch, A, Trebbia, G, Govindaradjou, K, Devaquet, J, Picard, C, Parquin, F, Leguen, M, Felten, M, Sage, E, Chapelier, A, Duruisseaux, M, Fleury, J, Antoine, M, Carette, M, Wislez, M, Givel, C, De Margerie Mellon, C, De Kerviler, E, Tandjaoui Lambiotte, Y, Freynet, O, Baux, E, Das, V, Talec, P, Anguel, N, Louis, G, Girerd, N, Tallon, P, Hadchouel Duvergé, A, Salvi, N, Cairet, P, Delacourt, C, Blandine, B, Beraud, L, Lamaziere, A, Lionnet, F, Lehingue, S, D'Journo, X, Jean Marie, F, Thibault, R, Makhlouf, A, Mulliez, A, Dadet, S, Kekstas, G, Preiser, J, Rotovnik, K, Rozalen, I, Kupczyk, K, Krznaric, Z, Cano, N, Pichard, C, Le Roux, B, Jotterand, 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Elkhawand, C, Vermeesh, F, Vermeesh, F., and CITERIO, GIUSEPPE
- Abstract
Determinants of outcome in critically ill patients with hematological malignancy and central neurological failure: data from the TRIAL OH study
- Published
- 2016
44. Paroxysmal hypothermia as a clinical feature of multiple sclerosis
- Author
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Nicolas WEISS, Dominique Hasboun, Demeret, S., Fontaine, B., Lyon-Caen, O., Chabas, D., Colliot, Olivier, Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière (CRICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Equipe NEMESIS - Centre de Recherches de l'Institut du Cerveau et de la Moelle épinière (NEMESIS-CRICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Cortex et Epilepsie [Paris], Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), CHU Pitié-Salpêtrière [AP-HP], and Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)
- Subjects
[INFO.INFO-IM]Computer Science [cs]/Medical Imaging ,[INFO.INFO-IM] Computer Science [cs]/Medical Imaging ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
- Published
- 2009
45. Concurrent excitatory and inhibitory effects of high frequency stimulation: an oculomotor study
- Author
-
Bejjani, B, Arnulf, I, Houeto, J, Milea, D, Demeret, S, Pidoux, B, Damier, P, Cornu, P, Dormont, D, and Agid, Y
- Subjects
Paper ,Male ,integumentary system ,Eye Movements ,Electric Stimulation Therapy ,Parkinson Disease ,Syndrome ,Middle Aged ,nervous system ,Oculomotor Nerve ,Mesencephalon ,Subthalamic Nucleus ,Humans ,Electrodes - Abstract
To describe a reversible neurological condition resembling a crossed midbrain syndrome resulting from high frequency stimulation (HFS) in the midbrain.Postoperative evaluation of quadripolar electrodes implanted in the area of the subthalamic nucleus of 25 patients with Parkinson's disease (PD) successfully treated by HFS.Four of the 25 patients experienced reversible acute diplopia, with dystonic posture and tremor in the contralateral upper limb when the white matter between the red nucleus and the substantia nigra was stimulated. The motor signs resembled those caused by lesions of the red nucleus. The ipsilateral resting eye position was "in and down" (three patients) or "in" (one patient). Enophthalmos was seen. Abduction was impaired and vertical eye movements were limited, but adduction was spared. The movements of the controlateral eye were normal. The ocular signs could be best explained by sustained hyperactivity of the extrinsic oculomotor nerve. Simultaneous tonic contraction of the superior rectus, the inferior rectus, and inferior oblique may cause the enophthalmos and partial limitation of upward and downward eye movements. Antagonist tonic contraction of the ipsilateral medial rectus severely impairs abduction.This crossed midbrain syndrome, possibly resulting from simultaneous activation of oculomotor nerve and lesion-like inhibition of the red nucleus suggests that high frequency stimulation has opposite effects on grey and white matter.
- Published
- 2002
46. Ventilation non invasive et myasthénie, une alternative judicieuse à la ventilation mécanique invasive ?
- Author
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Sabben, C., primary, Gales, A., additional, Demeret, S., additional, Bolgert, F., additional, and Weiss, N., additional
- Published
- 2013
- Full Text
- View/download PDF
47. Sporadic Creutzfeldt-Jakob disease mimicking nonconvulsive status epilepticus
- Author
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Lapergue, B., primary, Demeret, S., additional, Denys, V., additional, Laplanche, J. L., additional, Galanaud, D., additional, Verny, M., additional, Sazdovitch, V., additional, Baulac, M., additional, Haik, S., additional, Hauw, J. J., additional, Bolgert, F., additional, Brandel, J. P., additional, and Navarro, V., additional
- Published
- 2010
- Full Text
- View/download PDF
48. Paroxysmal hypothermia as a clinical feature of multiple sclerosis
- Author
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Weiss, N., primary, Hasboun, D., additional, Demeret, S., additional, Fontaine, B., additional, Bolgert, F., additional, Lyon-Caen, O., additional, and Chabas, D., additional
- Published
- 2009
- Full Text
- View/download PDF
49. C - 9 Méningo-encéphalites avec mouvements anormaux
- Author
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Laage, C., primary, Demeret, S., additional, Denys, V., additional, Garcin, B., additional, Rohaut, B., additional, and Bolgert, F., additional
- Published
- 2007
- Full Text
- View/download PDF
50. H - 10 Une leucoencéphalopathie révélant un lymphome intravasculaire
- Author
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Kinugawa, K., primary, Adam, J., additional, Denys, V., additional, Demeret, S., additional, Bolgert, F., additional, and Seilhean, D., additional
- Published
- 2007
- Full Text
- View/download PDF
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