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5. Clinical outcomes after discontinuing anticoagulant therapy in patients with first unprovoked venous thromboembolism

Author

Agudo, P., Aibar, J., Alberich-Conesa, A., Alda-Lozano, A., Alfonso, J., Amado, C., Angelina-García, M., Arcelus, J.I., Ballaz, A., Barba, R., Barbagelata, C., Barreiro, B., Barrón, M., Barrón-Andrés, B., Bascuñana, J., Beddar-Chaib, F., Blanco-Molina, A., Caballero, J.C., Cañas, I., Castellanos, G., Chasco, L., Claver, G., Criado, J., De Juana-Izquierdo, C., Del Toro, J., Demelo-Rodríguez, P., Díaz-Pedroche, M.C., Díaz-Peromingo, J.A., Dubois-Silva, A., Escribano, J.C., Falgá, C., Fernández-Aracil, C., Fernández-Capitán, C., Fernández-Jiménez, B., Fernández-Reyes, J.L., Fidalgo, M.A., Francisco, I., Gabara, C., Galeano-Valle, F., García-Bragado, F., García-Ortega, A., Gavín-Sebastián, O., Gil-Díaz, A., Gómez-Cuervo, C., González-Munera, A., Grau, E., Guirado, L., Gutiérrez-Guisado, J., Hernández-Blasco, L., Hernández-Molina, A., Hernández-Vidal, M.J., Jara-Palomares, L., Jiménez, D., Jou, I., Joya, M.D., Lalueza, A., Lecumberri, R., Llamas, P., Lobo, J.L., López-Brull, H., López-De la Fuente, M., López-Jiménez, L., López-Miguel, P., López-Núñez, J.J., López-Ruiz, A., López-Sáez, J.B., Lorente, M.A., Lorenzo, A., Lumbierres, M., Madridano, O., Maestre, A., Marchena, P.J., Marcos, M., Martín del Pozo, M., Martín-Martos, F., Martínez-Prado, R., Maza, J.M., Mercado, M.I., Moisés, J., Molino, A., Monreal, M., Monzón, L., Morales, M.V., Muñoz-Gamito, G., Navas, M.S., Nieto, J.A., Núñez-Fernández, M.J., Olid, M., Ordieres-Ortega, L., Ortiz, M., Osorio, J., Otálora, S., Otero, R., Pacheco-Gómez, N., Pagán, J., Palomeque, A.C., Paredes, E., Parra-Rosado, P., Pedrajas, J.M., Pérez-Ductor, C., Pérez-Pinar, M., Peris, M.L., Pesce, M.L., Porras, J.A., Puchades, R., Rivas, A., Rivera-Cívico, F., Rivera-Gallego, A., Rodríguez-Cobo, A., Romero-Bruguera, M., Ruiz-Artacho, P., Salgueiro, G., Sancho, T., Sendín, V., Sigüenza, P., Soler, S., Steinherr, A., Suárez-Fernández, S., Tirado, R., Torrents-Vilar, A., Torres, M.I., Trujillo-Santos, J., Uresandi, F., Valle, R., Varona, J.F., Villalobos, A., Villares, P., Ay, C., Nopp, S., Pabinger, I., Vanassche, T., Verhamme, P., Verstraete, A., Yoo, H.H.B., Montenegro, A.C., Morales, S.N., Roa, J., Hirmerova, J., Malý, R., Varhaník, F., Bertoletti, L., Bura-Riviere, A., Catella, J., Chopard, R., Couturaud, F., Espitia, O., Le Mao, R., Leclerq, B., Mahé, I., Moustafa, F., Plaisance, L., Sarlon-Bartoli, G., Suchon, P., Versini, E., Schellong, S., Brenner, B., Dally, N., Kenet, G., Tzoran, I., Rashidi, F., Sadeghipour, P., Tahmasbi, F., Abenante, A., Barillari, G., Bilora, F., Bissacco, D., Brandolin, B., Casana, R., Ciammaichella, M., Colaizzo, D., Dentali, F., Di Micco, P., Giorgi-Pierfranceschi, M., Grandone, E., Imbalzano, E., Lambertenghi-Deliliers, D., Martini, R., Meschi, T., Negro, F., Poz, A., Prandoni, P., Simioni, P., Siniscalchi, C., Taflaj, B., Ticinesi, A., Tufano, A., Visonà, A., Zalunardo, B., Kalnina, P., Kigitovica, D., Skride, A., Zicans, M., Nishimoto, Y., Yamashita, Y., Tazi-Mezalek, Z., Fonseca, S., Marques, R., Meireles, J., Pinto, S., Bosevski, M., Zdraveska, M., Bounameaux, H., Mazzolai, L., Aujayeb, A., Bikdeli, B., Caprini, J.A., Khalil, A., Tafur, J., Weinberg, I., Bui, H.M., Nguyen, S.T., Pham, K.Q., Tran, G.B., Gabara, Cristina, Aibar, Jesus, Nishimoto, Yuji, Yamashita, Yugo, Prandoni, Paolo, Barnes, Geoffrey D., Bikdeli, Behnood, Jiménez, David, Demelo-Rodríguez, Pablo, Peris, Ma Luisa, Nguyen, Son Truong, and Monreal, Manuel

Published
2024
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6. Risk of recurrence after discontinuing anticoagulation in patients with COVID-19- associated venous thromboembolism: a prospective multicentre cohort study

Author

Adarraga, María Dolores, Conesa, Ana Alberich, Aibar, Jesús, Lozano, Alicia Alda, Alfonso, Joaquín, Carrillo, Jesús Alonso, Amado, Cristina, García, María Angelina, Arcelus, Juan Ignacio, Ballaz, Aitor, Barba, Raquel, Hernando, María Barca, Barbagelata, Cristina, Barrón, Manuel, Andrés, Belén Barrón, Chaib, Fahd Beddar, Blanco Molina, María Ángeles, Caballero, Juan Carlos, Castellanos, Gonzalo, Chasco, Leyre, Criado, Juan, de Ancos, Cristina, Toro, Jorge del, Rodríguez, Pablo Demelo, de Juana Izquierdo, Cristina, Díaz Brasero, Ana María, Díaz Peromingo, José Antonio, Silva, Álvaro Dubois, Escribano, Juan Carlos, Falgá, Concepción, Farfán Sedano, Ana Isabel, Aracil, Cleofe Fernández, Capitán, Carmen Fernández, Jiménez, Begoña Fernández, Fernández Reyes, José Luis, Fidalgo, María Ángeles, Francisco, Iria, Gabara, Cristina, Valle, Francisco Galeano, Bragado, Francisco García, Ortega, Alberto García, Sebastián, Olga Gavín, Gil de Gómez, María Allende, Díaz, Aída Gil, Cuervo, Covadonga Gómez, Munera, Adriana González, Grau, Enric, Guirado, Leticia, Gutiérrez, Javier, Blasco, Luis Hernández, Palomares, Luis Jara, Jaras, María Jesús, Jiménez, David, Jiménez, Rafael, Jou, Inés, Joya, María Dolores, Justo, Sara Lainez, Lalueza, Antonio, Lecumberri, Ramón, León Ramírez, José Manuel, Llamas, Pilar, Lobo, José Luis, Jiménez, Luciano López, Miguel, Patricia López, López Núñez, Juan José, Ruiz, Antonio López, López Sáez, Juan Bosco, Lorenzo, Alicia, Lumbierres, Marina, Madridano, Olga, Maestre, Ana, Marchena, Pablo Javier, Marcos, María, Martín del Pozo, Mar, Martos, Francisco Martín, Maza, Jorge Manuel, Mena, Elisabeth, Mercado, Maria Isabel, Moisés, Jorge, Monreal, Manuel, Morales, María del Valle, Navas, Maria Sierra, Nieto, José Antonio, Núñez Fernández, Manuel Jesús, Olid, Mónica, Ortega, Lucía Ordieres, Ortiz, María, Osorio, Jeisson, Otálora, Sonia, Otero, Remedios, Gómez, Nazaret Pacheco, Pagán, Javier, Palomeque, Andrea Catalina, Paredes, Ezequiel, Caballero, Pedro Parra, Pedrajas, José María, Ductor, Cristina Pérez, Pinar, Montserrat Pérez, Peris, María Luisa, Pesce, María Lourdes, Porras, José Antonio, Puchades, Ramón, Cívico, Francisco Rivera, Cobo, Ana Rodríguez, Rosa, Vladimir, Brugera, Marta Romero, Artacho, Pedro Ruiz, Giménez, Nuria Ruiz, Ruiz, Justo Ruiz, Salgueiro, Georgina, Sancho, Teresa, Sendín, Vanesa, Sigüenza, Patricia, Soler, Silvia, Fernández, Susana Suárez, Tirado, Raimundo, Vilar, Ana Torrents, Torres, María Isabel, Santos, Javier Trujillo, Uresandi, Fernando, Valle, Reina, Varona, José Felipe, Villalobos, Aurora, Villares, Paula, Ay, Cihan, Nopp, Stephan, Pabinger, Ingrid, Engelen, Matthias, Vanassche, Thomas, Verhamme, Peter, Bok Yoo, Hugo Hyung, Montenegro, Ana Cristina, Morales, Silvia Natalia, Roa, Jairo, Hirmerova, Jana, Malý, Radovan, Bertoletti, Laurent, Bura-Riviere, Alessandra, Catella, Judith, Chopard, Romain, Couturaud, Francis, Espitia, Olivier, Grange, Claire, Leclercq, Barbara, Le Mao, Raphael, Mahé, Isabelle, Moustafa, Farès, Plaisance, Ludovic, Bartoli, Gabrielle Sarlon, Suchon, Pierre, Versini, Edouard, Schellong, Sebastian, Brenner, Benjamin, Dally, Najib, Tzoran, Inna, Sadeghipour, Parham, Rashidi, Fahrid, Abenante, Alessia, Barillari, Giovanni, Basaglia, Manuela, Bilora, Franca, Bissacco, Daniele, Bortoluzzi, Cristiano, Brandolin, Barbara, Casana, Renato, Ciammaichella, Maurizio, Colaizzo, Donatella, Dentali, Francesco, Di Micco, Pierpaolo, Grandone, Elvira, Imbalzano, Egidio, Deliliers, Daniela Lambertenghi, Negro, Federica, Pesavento, Raffaele, Poz, Alessandra, Prandoni, Paolo, Scarinzi, Paolo, Siniscalchi, Carmine, Taflaj, Beldisa, Tufano, Antonella, Visonà, Adriana, Hong, Ngoc Vo, Zalunardo, Beniamino, Skride, Andris, Kigitovica, Dana, Fonseca, Samuel, Marques, Rafael, Meireles, José, Pinto, Sara Barbosa, Bosevsky, Marijan, Eftimova, Aleksandra, Zdraveska, Marijan, Bounameaux, Henri, Mazzolai, Lucia, Aujayeb, Avinash, Bikdeli, Behnood, Caprini, Joseph, Weinberg, Ido, Bui, Hanh My, Jara-Palomares, Luis, Muriel, Alfonso, Demelo-Rodríguez, Pablo, López-Miguel, Patricia, López-Jiménez, Luciano, and Rivera-Cívico, Francisco

Published
2024
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8. COVID-19–associated venous thromboembolism: risk of recurrence and major bleeding

Author

Adarraga, M.D., Alberich-Conesa, A., Amado, C., Amorós, S., Arcelus, J.I., Ballaz, A., Barba, R., Barbagelata, C., Barrón, M., Barrón-Andrés, B., Blanco-Molina, A., Botella, E., Carrero, R., Casado, I., Criado, J., del Toro, J., De Ancos, C., De Juana-Izquierdo, C., Demelo-Rodríguez, P., Díaz-Brasero, A.M., Díaz-Pedroche, M.C., Díaz-Peromingo, J.A., Dubois-Silva, A., Escribano, J.C., Espósito, F., Falgá, C., Farfán-Sedano, A.I., Fernández-Capitán, C., Fernández-Jiménez, B., Fernández-Muixi, J., Fernández-Reyes, J.L., Font, C., Francisco, I., Galeano-Valle, F., García, M.A., García de Herreros, M., García-Bragado, F., García-Ortega, A., Gavín-Sebastián, O., Gil-Díaz, A., Gil-Hernández, A., Gómez-Cuervo, C., Gómez-Mosquera, A.M., González-Martínez, J., Grau, E., Guirado, L., Gutiérrez, J., Hernández-Blasco, L., Jara-Palomares, L., Jaras, M.J., Jiménez, D., Jou, I., Joya, M.D., Lacruz, B., Lalueza, A., Lainez-Justo, S., Lecumberri, R., León-Ramírez, J.M., Lobo, J.L., López-De la Fuente, M., López-Jiménez, L., López-Miguel, P., López-Núñez, J.J., López-Reyes, R., López-Ruiz, A., López-Sáez, J.B., Lorente, M.A., Lorenzo, A., Lumbierres, M., Madridano, O., Maestre, A., Mas-Maresma, L., Marcos, M., Martín-Guerra, J.M., Martín-Martos, F., Mellado, M., Mena, E., Mercado, M.I., Moisés, J., Monreal, M., Muñoz-Blanco, A., Muñoz-Gamito, G., Nieto, J.A., Núñez-Fernández, M.J., Osorio, J., Otalora, S., Pacheco-Gómez, N., Paredes-Ruiz, D., Parra, P., Pedrajas, J.M., Pérez-Ductor, C., Pérez-Jacoiste, A., Pérez-Pérez, J.L., Peris, M.L., Pesce, M.L., Porras, J.A., Poyo-Molina, J., Puchades, R., Riera-Mestre, A., Rivera-Civico, F., Rivera-Gallego, A., Roca, M., Rubio, C.M., Rosa, V., Rodríguez-Cobo, A., Ruiz-Giménez, N., Ruiz-Ruiz, J., Salgueiro, G., Sancho, T., Sendín, V., Sigüenza, P., Soler, S., Suriñach, J.M., Tiberio, G., Tolosa, C., Torres, M.I., Trujillo-Santos, J., Uresandi, F., Usandizaga, E., Valle, R., Varona, J.F., Vela, J.R., Vela, L., Vidal, G., Villalobos, A., Villares, P., Ay, C., Nopp, S., Pabinger, I., Engelen, M., Martens, C., Verhamme, P., Yoo, H.H.B., Arguello, J.D., Montenegro, A.C., Roa, J., Hirmerova, J., Malý, R., Accassat, S., Bertoletti, L., Bura-Riviere, A., Catella, J., Chopard, R., Couturaud, F., Espitia, O., Grange, C., Leclercq, B., Le Mao, R., Mahé, I., Moustafa, F., Plaisance, L., Poenou, G., Sarlon-Bartoli, G., Suchon, P., Versini, E., Schellong, S., Braester, A., Brenner, B., Kenet, G., Najib, D., Tzoran, I., Farrashi, M., Sadeghipour, P., Basaglia, M., Bilora, F., Bortoluzzi, C., Brandolin, B., Ciammaichella, M., Colaizzo, D., Dentali, F., Di Micco, P., Grandone, E., Imbalzano, E., Merla, S., Pesavento, R., Prandoni, P., Scarinzi, P., Siniscalchi, C., Taflaj, B., Tufano, A., Visonà, A., Vo Hong, N., Zalunardo, B., Fonseca, S., Manuel, M., Meireles, J., Bosevski, M., Eftimova, A., Zdraveska, M., Bounameaux, H., Mazzolai, L., Aujayeb, A., Caprini, J.A., Weinberg, I., Bui, H.M., Demelo-Rodriguez, Pablo, Alonso-Beato, Rubén, Jara-Palomares, Luis, Galeano-Valle, Francisco, Bura-Riviere, Alessandra, Visonà, Adriana, Francisco, Iria, Vidal, Gemma, López-Ruiz, Antonio, and Monreal, Manuel

Published
2023
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13. Rate of recurrence after discontinuing anticoagulation in patients with venous thromboembolism within 30 days after COVID‐19 vaccine.

Author

Jara‐Palomares, Luis, Bikdeli, Behnood, Jiménez, David, Muriel, Alfonso, Demelo‐Rodríguez, Pablo, Mahé, Isabelle, López‐Núñez, Juan José, Megido, Joaquín Alfonso, Fernández Jiménez, Begoña, Monreal, Manuel, Prandoni, Paolo, Brenner, Benjamin, Farge‐Bancel, Dominique, Barba, Raquel, Di Micco, Pierpaolo, Bertoletti, Laurent, Schellong, Sebastian, Tzoran, Inna, Reis, Abilio, and Bosevski, Marijan

Subjects
INFORMED consent (Medical law), VENOUS thrombosis, WOMEN'S hospitals, TEACHING awards, VACCINE trials, PULMONARY embolism
Abstract

The study examined the rate of recurrent venous thromboembolism (VTE) after discontinuing anticoagulation in patients who developed VTE within 30 days of receiving a COVID-19 vaccine. The findings indicated a low recurrence rate of VTE after stopping anticoagulant therapy, suggesting a relatively low risk of recurrent thrombotic events post-cessation. The study highlighted the importance of individualized patient assessment when determining the duration of anticoagulant therapy in VTE after COVID-19 vaccination, offering valuable insights for clinicians in managing potential vaccine-related adverse events. [Extracted from the article]

Published
2024
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14. Risk of recurrence after discontinuing anticoagulation in patients with COVID-19- associated venous thromboembolism: a prospective multicentre cohort study

Author

Jara-Palomares, Luis, primary, Bikdeli, Behnood, additional, Jiménez, David, additional, Muriel, Alfonso, additional, Demelo-Rodríguez, Pablo, additional, Moustafa, Farès, additional, Villalobos, Aurora, additional, López-Miguel, Patricia, additional, López-Jiménez, Luciano, additional, Otálora, Sonia, additional, Peris, María Luisa, additional, Amado, Cristina, additional, Chopard, Romain, additional, Rivera-Cívico, Francisco, additional, Monreal, Manuel, additional, Adarraga, María Dolores, additional, Conesa, Ana Alberich, additional, Aibar, Jesús, additional, Lozano, Alicia Alda, additional, Alfonso, Joaquín, additional, Carrillo, Jesús Alonso, additional, García, María Angelina, additional, Arcelus, Juan Ignacio, additional, Ballaz, Aitor, additional, Barba, Raquel, additional, Hernando, María Barca, additional, Barbagelata, Cristina, additional, Barrón, Manuel, additional, Andrés, Belén Barrón, additional, Chaib, Fahd Beddar, additional, Blanco Molina, María Ángeles, additional, Caballero, Juan Carlos, additional, Castellanos, Gonzalo, additional, Chasco, Leyre, additional, Criado, Juan, additional, de Ancos, Cristina, additional, Toro, Jorge del, additional, Rodríguez, Pablo Demelo, additional, de Juana Izquierdo, Cristina, additional, Díaz Brasero, Ana María, additional, Díaz Peromingo, José Antonio, additional, Silva, Álvaro Dubois, additional, Escribano, Juan Carlos, additional, Falgá, Concepción, additional, Farfán Sedano, Ana Isabel, additional, Aracil, Cleofe Fernández, additional, Capitán, Carmen Fernández, additional, Jiménez, Begoña Fernández, additional, Fernández Reyes, José Luis, additional, Fidalgo, María Ángeles, additional, Francisco, Iria, additional, Gabara, Cristina, additional, Valle, Francisco Galeano, additional, Bragado, Francisco García, additional, Ortega, Alberto García, additional, Sebastián, Olga Gavín, additional, Gil de Gómez, María Allende, additional, Díaz, Aída Gil, additional, Cuervo, Covadonga Gómez, additional, Munera, Adriana González, additional, Grau, Enric, additional, Guirado, Leticia, additional, Gutiérrez, Javier, additional, Blasco, Luis Hernández, additional, Palomares, Luis Jara, additional, Jaras, María Jesús, additional, Jiménez, Rafael, additional, Jou, Inés, additional, Joya, María Dolores, additional, Justo, Sara Lainez, additional, Lalueza, Antonio, additional, Lecumberri, Ramón, additional, León Ramírez, José Manuel, additional, Llamas, Pilar, additional, Lobo, José Luis, additional, Jiménez, Luciano López, additional, Miguel, Patricia López, additional, López Núñez, Juan José, additional, Ruiz, Antonio López, additional, López Sáez, Juan Bosco, additional, Lorenzo, Alicia, additional, Lumbierres, Marina, additional, Madridano, Olga, additional, Maestre, Ana, additional, Marchena, Pablo Javier, additional, Marcos, María, additional, Martín del Pozo, Mar, additional, Martos, Francisco Martín, additional, Maza, Jorge Manuel, additional, Mena, Elisabeth, additional, Mercado, Maria Isabel, additional, Moisés, Jorge, additional, Morales, María del Valle, additional, Navas, Maria Sierra, additional, Nieto, José Antonio, additional, Núñez Fernández, Manuel Jesús, additional, Olid, Mónica, additional, Ortega, Lucía Ordieres, additional, Ortiz, María, additional, Osorio, Jeisson, additional, Otero, Remedios, additional, Gómez, Nazaret Pacheco, additional, Pagán, Javier, additional, Palomeque, Andrea Catalina, additional, Paredes, Ezequiel, additional, Caballero, Pedro Parra, additional, Pedrajas, José María, additional, Ductor, Cristina Pérez, additional, Pinar, Montserrat Pérez, additional, Pesce, María Lourdes, additional, Porras, José Antonio, additional, Puchades, Ramón, additional, Cívico, Francisco Rivera, additional, Cobo, Ana Rodríguez, additional, Rosa, Vladimir, additional, Brugera, Marta Romero, additional, Artacho, Pedro Ruiz, additional, Giménez, Nuria Ruiz, additional, Ruiz, Justo Ruiz, additional, Salgueiro, Georgina, additional, Sancho, Teresa, additional, Sendín, Vanesa, additional, Sigüenza, Patricia, additional, Soler, Silvia, additional, Fernández, Susana Suárez, additional, Tirado, Raimundo, additional, Vilar, Ana Torrents, additional, Torres, María Isabel, additional, Santos, Javier Trujillo, additional, Uresandi, Fernando, additional, Valle, Reina, additional, Varona, José Felipe, additional, Villares, Paula, additional, Ay, Cihan, additional, Nopp, Stephan, additional, Pabinger, Ingrid, additional, Engelen, Matthias, additional, Vanassche, Thomas, additional, Verhamme, Peter, additional, Bok Yoo, Hugo Hyung, additional, Montenegro, Ana Cristina, additional, Morales, Silvia Natalia, additional, Roa, Jairo, additional, Hirmerova, Jana, additional, Malý, Radovan, additional, Bertoletti, Laurent, additional, Bura-Riviere, Alessandra, additional, Catella, Judith, additional, Couturaud, Francis, additional, Espitia, Olivier, additional, Grange, Claire, additional, Leclercq, Barbara, additional, Le Mao, Raphael, additional, Mahé, Isabelle, additional, Plaisance, Ludovic, additional, Bartoli, Gabrielle Sarlon, additional, Suchon, Pierre, additional, Versini, Edouard, additional, Schellong, Sebastian, additional, Brenner, Benjamin, additional, Dally, Najib, additional, Tzoran, Inna, additional, Sadeghipour, Parham, additional, Rashidi, Fahrid, additional, Abenante, Alessia, additional, Barillari, Giovanni, additional, Basaglia, Manuela, additional, Bilora, Franca, additional, Bissacco, Daniele, additional, Bortoluzzi, Cristiano, additional, Brandolin, Barbara, additional, Casana, Renato, additional, Ciammaichella, Maurizio, additional, Colaizzo, Donatella, additional, Dentali, Francesco, additional, Di Micco, Pierpaolo, additional, Grandone, Elvira, additional, Imbalzano, Egidio, additional, Deliliers, Daniela Lambertenghi, additional, Negro, Federica, additional, Pesavento, Raffaele, additional, Poz, Alessandra, additional, Prandoni, Paolo, additional, Scarinzi, Paolo, additional, Siniscalchi, Carmine, additional, Taflaj, Beldisa, additional, Tufano, Antonella, additional, Visonà, Adriana, additional, Hong, Ngoc Vo, additional, Zalunardo, Beniamino, additional, Skride, Andris, additional, Kigitovica, Dana, additional, Fonseca, Samuel, additional, Marques, Rafael, additional, Meireles, José, additional, Pinto, Sara Barbosa, additional, Bosevsky, Marijan, additional, Eftimova, Aleksandra, additional, Zdraveska, Marijan, additional, Bounameaux, Henri, additional, Mazzolai, Lucia, additional, Aujayeb, Avinash, additional, Caprini, Joseph, additional, Weinberg, Ido, additional, and Bui, Hanh My, additional

Published
2024
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15. Bleeding risk in hospitalized patients with COVID‐19 receiving intermediate‐ or therapeutic doses of thromboprophylaxis

Author

Demelo‐Rodriguez, Pablo, Farfán‐Sedano, Ana Isabel, Pedrajas, José María, Llamas, Pilar, Sigüenza, Patricia, Jaras, María Jesús, Quintana‐Diaz, Manuel, Fernández‐Capitán, Carmen, Bikdeli, Behnood, Jiménez, David, Monreal, Manuel, D, Adarraga, J, Aibar, C, Baeza, A, Ballaz, R, Barba, A, Blanco‐Molina, E, Botella, J, Criado, P, Demelo‐Rodríguez, AM, Díaz‐Brasero, C, de Ancos, J, del Toro, AI, Farfán‐Sedano, C, Fernández‐Capitán, A, Fidalgo, K, Flores, C, Gabara, F, Galeano‐Valle, O, Gavín‐Sebastián, A, Gil‐Díaz, MJ, Jaras, L, Jara‐Palomares, R, Jiménez, S, Lainez‐Justo, A, Latorre, R, Lecumberri, P, Llamas, JL, Lobo, L, López‐Jiménez, B, Loureiro, O, Madridano, AB, Mancebo‐Plaza, M, Martín del Pozo, M, Monreal, N, Muñoz‐Rivas, MJ, Núñez‐Fernández, PE, Olivera, L, Ordieres‐Ortega, EM, Padín‐Paz, JM, Pedrajas, M, Quintana‐Díaz, M, Ríos‐Prego, DA, Rodríguez‐Chiaradía, P, Ruiz‐Artacho, P, Sigüenza, JM, Suriñach, J, Trujillo‐Santos, C, Zamora, E, Bucherini, P, Di Micco, E, Imbalzano, C, Siniscalchi, M, Bosevski, M, Stevanovic, L, Paz‐Rios, and I, Weinberg

Published
2021
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17. Optimizing Venous Stenting: Consensus Recommendations for Enhanced Management of Lower Extremity Deep Vein Thrombosis.

Author

Trujillo-Santos, Javier, Demelo-Rodríguez, Pablo, Bravo de Laguna-Taboada, Alexis, Zubicoa-Ezpeleta, Santiago, Rodríguez-Morata, Alejandro, Lojo-Rocamonde, Ignacio, and Riera-Mestre, Antoni

Subjects
*VENOUS thrombosis, *POSTTHROMBOTIC syndrome, *VASCULAR surgery, *LIKERT scale, *INTERNAL medicine, *INTERVENTIONAL radiology
Abstract

Introduction Deep vein thrombosis (DVT) poses a complex challenge and often leads to postthrombotic syndrome (PTS), a debilitating complication. The emergence of venous stents offers a potential preventive avenue against this complication. This study aimed to provide consensus recommendations on the use of venous stent for DVT. Materials and Methods From June to July 2023, 20 internal medicine, angiology and vascular surgery, and vascular and interventional radiology experts were involved in the Delphi process. Thirty-one recommendations, categorized into three thematic areas, were rigorously evaluated: indications for stent use, stent selection and placement, and monitoring and prevention of complications. Agreement was evaluated using a Likert scale, with consensus defined as agreement by two-thirds of the participants. Results Consensus was reached for 23 (74.2%) of 31 recommendations. The agreement was centered on considerations, such as stent placement in specific acute DVT scenarios, emphasizing pivotal stent characteristics. However, there were divergences in the recommended stent length to prevent migration and stent characteristics based on iliocaval bifurcation morphology. Notably, there was no consensus on whether patients with DVT caused by a major transient risk factor need more than 3 months of anticoagulation therapy or whether aspirin should be added to anticoagulant treatment after venous stenting. Conclusions These consensus recommendations offer practical insights into optimizing venous stent use to prevent PTS in DVT patients. Addressing the critical aspects of stent selection, placement, and postprocedural care, these recommendations contribute to clinical decision-making. The identified divergences underscore the importance of consensus and thus indicate the need for further investigation. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Evaluation of soluble P‐selectin as a predictive biomarker in acute symptomatic pulmonary embolism: Insights from a prospective observational study.

Author

Oblitas, Crhistian‐Mario, Demelo‐Rodríguez, Pablo, López‐Rubio, Marina, Lago‐Rodríguez, Marta‐Olimpia, García‐Gámiz, Mercedes, Zamora‐Trillo, Angielys, Alvarez‐Sala Walther, Luis‐Antonio, García‐Martínez, Rita, and Galeano‐Valle, Francisco

Subjects
*PULMONARY embolism, *BIOMARKERS, *LONGITUDINAL method, *THROMBOEMBOLISM, *SCIENTIFIC observation
Abstract

Background: Soluble P‐selectin (sP‐selectin) has been proposed as a potential biomarker for venous thromboembolism (VTE) diagnosis with interesting results. However, its role in predicting early mortality in pulmonary embolism (PE) remains unexplored. Methods: This observational, prospective, single‐center study enrolled consecutive patients aged 18 or older with confirmed acute symptomatic PE and no prior anticoagulation. The study aims to assess the prognostic capacity of sP‐selectin measured at the time of PE diagnosis for short‐term mortality and major bleeding. Results: A total of 196 patients, with a mean age of 69.1 years (SD 17), were included, of whom 52.6% were male. Within 30 days, 9.7% of patients (n = 19) died, and 5.1% (n = 10) suffered major bleeding. PE risk stratification revealed 4.6% (n = 9) with high‐risk PE, 34.7% (n = 68) with intermediate‐high‐risk PE, 38.3% (n = 75) with intermediate‐low‐risk PE, and 22.5% (n = 44) with low‐risk PE according to the European Society of Cardiology score. Mean plasma sP‐selectin levels were comparable between survivors and non‐survivors (489.7 ng/mL ±63 vs. 497.3 ng/mL ±51; p =.9). The ROC curve for 30‐day all‐cause mortality and major bleeding yielded an AUC of 0.49 (95% CI 0.36–0.63) and 0.46 (95% CI 0.24–0.68), respectively. Multivariate and survival analyses were precluded due to lack of significance. Conclusions: sP‐selectin was not useful for predicting short‐term mortality or major bleeding in patients with acute symptomatic pulmonary embolism. Further studies are required to clarify the role of sP‐selectin in VTE, particularly in prognosticating PE outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Evaluation of simple laboratory parameters in SARS-CoV-2 infection: the role of ratios

Author

Oblitas, C.M., Galeano Valle, Francisco, Álvarez-Sala Walther, Luis Antonio, Demelo Rodríguez, Pablo, Oblitas, C.M., Galeano Valle, Francisco, Álvarez-Sala Walther, Luis Antonio, and Demelo Rodríguez, Pablo

Abstract

Background: The real predictive prognostic capacity of cellular indices (or ratios) is unclear in SARS-CoV-2 infection. This study aimed to assess the prognostic role of previously well-known laboratory indices and new ones in hospitalized COVID-19 patients. Methods: A retrospective observational study from March to May 2022 evaluated laboratory indices on admission (neutrophil to lymphocyte-, derived neutrophil to lymphocyte-, platelet to lymphocyte-, CRP to lymphocyte-, CRP to albumin-, fibrinogen to lymphocyte-, d-dimer to lymphocyte-, ferritin to lymphocyte-, LDH to lymphocyte-, and IL-6 to lymphocyte ratios), in patients hospitalized due to SARS-CoV2 infection to determine the association with mortality, admission to an intensive care unit (ICU), need for non-invasive mechanical ventilation (NIMV), orotracheal intubation (OTI), or combined event at 30 days follow-up. Results: A total of 1113 COVID-19 patients were evaluated with a mean age of 64.1 ± 15.9 years (58.49% male), 166 (14.91%) patients died, 58 (5.21%) required ICU admission, 73 (6.56%) needed NIMV, 46 (4.23%) needed OTI, and 247 (22.19%) presented the combined event. All the ratios evaluated in this study showed statistical significance in the univariate analysis for mortality and combined event; however, only d-dimer to lymphocyte ratio >0.6 presented an independent association in the multivariate analysis for 30-day mortality (adjusted OR 2.32; p = .047) and 30-day combined event (adjusted OR 2.62; p = .014). Conclusions: Laboratory indices might be a potential biomarker for better prognosis stratification in hospitalized COVID-19 patients. d-Dimer to lymphocyte ratio presents an independent association for 30-day mortality and 30-day adverse outcomes in hospitalized COVID-19 patients., Depto. de Medicina, Fac. de Medicina, TRUE, pub

Published
2024

25. The Potential Role of CA-125 as a Biomarker for Short-Term Mortality Risk in Patients with Acute Symptomatic Pulmonary Embolism.

Author

Oblitas, Crhistian-Mario, Galeano-Valle, Francisco, Lago-Rodríguez, Marta-Olimpia, López-Rubio, Marina, Baltasar-Corral, Jesús, García-Gámiz, Mercedes, Zamora-Trillo, Angielys, Alvarez-Sala Walther, Luis-Antonio, and Demelo-Rodríguez, Pablo

Subjects
PULMONARY embolism, BIOMARKERS, MORTALITY, RECEIVER operating characteristic curves, HEART failure
Abstract

Background: Antigen carbohydrate 125 (CA-125) is a complex glycoprotein extensively studied as a prognostic biomarker in heart failure, yet its potential role in the short-term prognosis of an acute pulmonary embolism (PE) remains unexplored. Methods: In this observational, prospective, single-center study, consecutive patients aged 18 and older with a confirmed acute symptomatic PE and no history of prior anticoagulant therapy were enrolled. Primary and secondary objectives aimed to assess the prognostic capacity of CA-125 at PE diagnosis for 30-day mortality and major bleeding, respectively. Results: A total of 164 patients were included (mean age 69.8 years, SD 17), with 56.1% being male. Within 30 days, 17 patients (10.4%) died and 9 patients (5.5%) suffered major bleeding. ROC curve analysis for 30-day mortality yielded an area under the curve of 0.69 (95% CI 0.53–0.85) with an optimal CA-125 cut-off point of 20 U/mL and a negative predictive value of 96%. Multivariate analysis revealed a significant association between CA-125 levels exceeding 20 U/mL and 30-day mortality (adjusted odds ratio 4.95; 95% CI 1.61–15.2) after adjusting for age, cancer, NT-proBNP > 600 ng/mL, and the simplified pulmonary embolism severity index score. Survival analysis for 30-day mortality exhibited a hazard ratio of 5.47 (95% CI 1.78–16.8). No association between CA-125 levels and 30-day major bleeding was found. Conclusions: CA-125 emerges as a promising surrogate biomarker for short-term mortality prediction in an acute symptomatic PE. Future investigations should explore the integration of CA-125 into PE mortality prediction scores to enhance the prognostic accuracy in this patient population. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Prognostic Value of D-dimer to Lymphocyte Ratio (DLR) in Hospitalized Coronavirus Disease 2019 (COVID-19) Patients: A Validation Study in a National Cohort.

Author

Oblitas, Crhistian-Mario, Demelo-Rodríguez, Pablo, Alvarez-Sala-Walther, Luis-Antonio, Rubio-Rivas, Manuel, Navarro-Romero, Francisco, Giner Galvañ, Vicente, de Jorge-Huerta, Lucía, Fonseca Aizpuru, Eva, García García, Gema María, Beato Pérez, José Luis, Pesqueira Fontan, Paula María, Artero Mora, Arturo, Vargas Núñez, Juan Antonio, Ramírez Perea, Nuria, García Bruñén, José Miguel, Roy Vallejo, Emilia, Perales-Fraile, Isabel, Gil Sánchez, Ricardo, López Castro, José, and Martínez González, Ángel Luis

Subjects
*COVID-19, *PROGNOSIS, *FIBRIN fragment D, *LYMPHOCYTES, *INTENSIVE care units
Abstract

Background: This study aimed to validate the role of the D-dimer to lymphocyte ratio (DLR) for mortality prediction in a large national cohort of hospitalized coronavirus disease 2019 (COVID-19) patients. Methods: A retrospective, multicenter, observational study that included hospitalized patients due to SARS-CoV-2 infection in Spain was conducted from March 2020 to March 2022. All biomarkers and laboratory indices analyzed were measured once at admission. Results: A total of 10,575 COVID-19 patients were included in this study. The mean age of participants was 66.9 (±16) years, and 58.6% (6202 patients) of them were male. The overall mortality rate was 16.3% (n = 1726 patients). Intensive care unit admission was needed in 10.5% (n = 1106 patients), non-invasive mechanical ventilation was required in 8.8% (n = 923 patients), and orotracheal intubation was required in 7.5% (789 patients). DLR presented a c-statistic of 0.69 (95% CI, 0.68–0.71) for in-hospital mortality with an optimal cut-off above 1. Multivariate analysis showed an independent association for in-hospital mortality for DLR > 1 (adjusted OR 2.09, 95% CI 1.09–4.04; p = 0.03); in the same way, survival analysis showed a higher mortality risk for DLR > 1 (HR 2.24; 95% CI 2.03–2.47; p < 0.01). Further, no other laboratory indices showed an independent association for mortality in multivariate analysis. Conclusions: This study confirmed the usefulness of DLR as a prognostic biomarker for mortality associated with SARS-CoV-2 infection, being an accessible, cost-effective, and easy-to-use biomarker in daily clinical practice. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Prognostic Significance of Heart Failure in Acute Pulmonary Embolism: A Comprehensive Assessment of 30-Day Outcomes.

Author

Farid-Zahran, Mariam, Méndez-Bailón, Manuel, Pedrajas, José María, Alonso-Beato, Rubén, Galeano-Valle, Francisco, Sendín Martín, Vanesa, Marco-Martínez, Javier, and Demelo-Rodríguez, Pablo

Subjects
HEART failure, PULMONARY embolism, VENTRICULAR ejection fraction, HEART failure patients, PROGNOSIS, MULTIVARIATE analysis
Abstract

Introduction: Patients with heart failure (HF) are known to have an increased risk of pulmonary embolism (PE), but there is limited evidence regarding the prognostic implications of HF in patients with acute PE and the relationship between PE prognosis and left ventricular ejection fraction (LVEF). The primary objective of this study was the development of a composite outcome (mortality, major bleeding, and recurrence) within the first 30 days. The secondary objective was to identify the role of LVEF in predicting the development of early complications in patients with both HF and reduced LVEF. Material and Methods: A prospective study was conducted at two tertiary hospitals between January 2012 and December 2022 to assess differences among patients diagnosed with acute PE based on the presence or absence of a history of HF. Cox regression models were employed to assess the impact of HF and reduced LVEF on the composite outcome at 30 days. Results: Out of 1991 patients with acute symptomatic PE, 7.13% had a history of HF. Patients with HF were older and had more comorbidities. The HF group exhibited higher mortality (11.27% vs. 4.33%, p < 0.001) and a higher incidence of major bleeding (9.86% vs. 4.54%, p = 0.005). In the multivariate analysis, HF was an independent risk factor for the development of the composite outcome (HR 1.93; 95% CI 1.35–2.76). Reduced LVEF was independently associated with a higher risk of major bleeding (HR 3.44; 95% CI 1.34–8.81). Conclusion: In patients with acute pulmonary embolism, heart failure is independently associated with a higher risk of early complications. Additionally, heart failure with reduced LVEF is an independent risk factor for major bleeding. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Evaluation of simple laboratory parameters in SARS-CoV-2 infection: the role of ratios

Author

Oblitas, Crhistian-Mario, primary, Galeano-Valle, Francisco, additional, Cuenca-Carvajal, Carmen, additional, Piqueras-Ruiz, Sandra, additional, Alonso-Beato, Rubén, additional, Alejandre-de-Oña, Álvaro, additional, Carrascosa-Fernández, Paula, additional, Chacón Moreno, Agustín-Diego, additional, Parra-Virto, Alejandro, additional, Pérez Sanz, María-Teresa, additional, Abarca Casas, Laura, additional, Millán-Nohales, Clara, additional, Álvarez-Sala-Walther, Luis, additional, and Demelo-Rodríguez, Pablo, additional

Published
2022
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39. Efficacy and Safety of Tinzaparin in Prophylactic, Intermediate and Therapeutic Doses in Non-Critically Ill Patients Hospitalized with COVID-19: The PROTHROMCOVID Randomized Controlled Trial

Author

Muñoz-Rivas, Nuria, primary, Aibar, Jesús, additional, Gabara-Xancó, Cristina, additional, Trueba-Vicente, Ángela, additional, Urbelz-Pérez, Ana, additional, Gómez-Del Olmo, Vicente, additional, Demelo-Rodríguez, Pablo, additional, Rivera-Gallego, Alberto, additional, Bosch-Nicolau, Pau, additional, Perez-Pinar, Montserrat, additional, Rios-Prego, Mónica, additional, Madridano-Cobo, Olga, additional, Ramos-Alonso, Laura, additional, Alonso-Carrillo, Jesús, additional, Francisco-Albelsa, Iria, additional, Martí-Saez, Edelmira, additional, Maestre-Peiró, Ana, additional, Méndez-Bailón, Manuel, additional, Hernández-Rivas, José Ángel, additional, and Torres-Macho, Juan, additional

Published
2022
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40. Venous Thrombosis within 30 Days after Vaccination against SARS-CoV-2 in a Multinational Venous Thromboembolism Registry

Author

Bikdeli, Behnood, Jiménez, David, Demelo Rodríguez, Pablo, Galeano Valle, Francisco, Porras, José Antonio, Barba, Raquel, Ay, Cihan, Malý, Radovan, Braester, Andrei, Imbalzano, Egidio, Rosa, Vladimir, Lecumberri, Ramón, Siniscalchi, Carmine, Fidalgo, Ángeles, Ortiz, Salvador, Monreal, Manuel, Bikdeli, Behnood, Jiménez, David, Demelo Rodríguez, Pablo, Galeano Valle, Francisco, Porras, José Antonio, Barba, Raquel, Ay, Cihan, Malý, Radovan, Braester, Andrei, Imbalzano, Egidio, Rosa, Vladimir, Lecumberri, Ramón, Siniscalchi, Carmine, Fidalgo, Ángeles, Ortiz, Salvador, and Monreal, Manuel

Abstract

Background: Venous thromboembolism (VTE)—including deep vein thrombosis, pulmonary embolism, and cerebral venous sinus thrombosis (CVST)—may occur early after vaccination against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We sought to describe the site, clinical characteristics, and outcomes of VTE after vaccination against SARS-CoV-2. Methods: In a prospective study using the Registro Informatizado de Enfermedad TromboEmbólica (RIETE) platform, patients with VTE 4–30 days after vaccination against SARS-CoV-2 (1 February 2021 through 30 April 2021) were included. VTE patients recruited from the same centers into RIETE in the same months in 2018–2019 were selected as the reference group. All-cause mortality and major bleeding were the main study outcomes. Results: As of 30 April 2020, 102 patients with post-vaccination VTEs had been identified (28 after adenovirus-based vaccination [ChAdOx1 nCov-19; AstraZeneca] and 74 after mRNA-based vaccination [mRNA-1273; Moderna, and BNT162b2; Pfizer]). Compared with 911 historical controls, patients with VTE after adenovirus-based vaccination more frequently had CVST (10.7% vs. 0.4%, p < 0.001) or thrombosis at multiple sites (17.9% vs. 1.3%, p < 0.001), more frequently had thrombocytopenia (40.7% vs. 14.7%, p < 0.001), and had higher 14-day mortality (14.3% vs. 0.7%; odds ratio [OR]: 25.1; 95% confidence interval [CI]: 6.7–94.9) and major bleeding rates (10.3% vs. 1.0%, OR: 12.03, 95% CI: 3.07–47.13). The site of thrombosis, accompanying thrombocytopenia, and 14-day mortality rates were not significantly different for patients with VTE after mRNA-based vaccination, compared with historical controls. Conclusions: Compared with historical controls, VTE after adenovirus-based vaccination against SARS-CoV-2 is accompanied by thrombocytopenia, occurs in unusual sites, and is associated with worse clinical outcomes., Depto. de Medicina, Fac. de Medicina, TRUE, pub

Published
2022

41. Visceral extra‐abdominal panniculitis after COVID19.

Author

Ausín‐García, Cristina, Cervilla‐Muñoz, Eva, Demelo‐Rodríguez, Pablo, Villalba‐García, María Victoria, and Alvarez‐Sala Walther, Luis A.

Subjects
ADIPOSE tissue diseases, COVID-19, AUTOINFLAMMATORY diseases, ADIPOSE tissues, PERSONAL names, AUTOIMMUNE diseases
Abstract

"Retractile mesenteritis" was the first name given to a rare, benign, inflammatory disease that affects the adipose tissue of the intestinal mesentery and less frequently other locations. Now labeled as mesenteric panniculitis, the pathogenic mechanism remains unclear. Several stimuli could be involved, and it is sometimes associated with other conditions such as malignancy or autoimmune diseases. We present a case of mesenteric panniculitis with extensive abdominal and extra‐abdominal involvement that developed a few months after SARS‐COV2 infection, raising the hypothesis of this virus as a potential trigger for autoinflammatory and autoimmune diseases. [ABSTRACT FROM AUTHOR]

Published
2023
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42. Mid-Regional Pro-Adrenomedullin, Methemoglobin and Carboxyhemoglobin as Prognosis Biomarkers in Critically Ill Patients with COVID-19: An Observational Prospective Study

Author

Oblitas, Crhistian-Mario, primary, Galeano-Valle, Francisco, additional, Ramírez-Navarro, Jesús, additional, López-Cano, Jorge, additional, Monterrubio-Manrique, Ángel, additional, García-Gámiz, Mercedes, additional, Sancho-González, Milagros, additional, Arenal-López, Sara, additional, Álvarez-Sala Walther, Luis-Antonio, additional, and Demelo-Rodríguez, Pablo, additional

Published
2021
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43. Association Between Preexisting Versus Newly Identified Atrial Fibrillation and Outcomes of Patients With Acute Pulmonary Embolism

Author

Bikdeli, Behnood, primary, Jiménez, David, additional, del Toro, Jorge, additional, Piazza, Gregory, additional, Rivas, Agustina, additional, Fernández‐Reyes, José Luis, additional, Sampériz, Ángel, additional, Otero, Remedios, additional, Suriñach, José María, additional, Siniscalchi, Carmine, additional, Martín‐Guerra, Javier Miguel, additional, Castro, Joaquín, additional, Muriel, Alfonso, additional, Lip, Gregory Y. H., additional, Goldhaber, Samuel Z., additional, Monreal, Manuel, additional, Prandoni, Paolo, additional, Brenner, Benjamin, additional, Farge‐Bancel, Dominique, additional, Barba, Raquel, additional, Di Micco, Pierpaolo, additional, Bertoletti, Laurent, additional, Schellong, Sebastian, additional, Tzoran, Inna, additional, Reis, Abilio, additional, Bosevski, Marijan, additional, Bounameaux, Henri, additional, Malý, Radovan, additional, Verhamme, Peter, additional, Caprini, Joseph A., additional, Bui, Hanh My, additional, Adarraga, María Dolores, additional, Agud, María, additional, Aibar, Jesús, additional, Aibar, Miguel Ángel, additional, Amado, Cristina, additional, Arcelus, Juan Ignacio, additional, Baeza, Carlos, additional, Ballaz, Aitor, additional, Barbagelata, Cristina, additional, Barrón, Manuel, additional, Barrón‐Andrés, Belén, additional, Blanco‐Molina, Ángeles, additional, Botella, Ernesto, additional, Camon, Ana María, additional, Cañas, Inmaculada, additional, Casado, Ignacio, additional, Chasco, Leyre, additional, Criado, Juan, additional, de Ancos, Cristina, additional, de Miguel, Javier, additional, Demelo‐Rodríguez, Pablo, additional, Díaz‐Peromingo, José Antonio, additional, Di Campli, Mario Virgilio, additional, Díez‐Sierra, Javier, additional, Domínguez, Irene Milagros, additional, Escribano, José Carlos, additional, Falgá, Conxita, additional, Farfán‐Sedano, Ana Isabel, additional, Fernández‐Capitán, Carmen, additional, Fernández‐Reyes, Jose Luis, additional, Fidalgo, María Ángeles, additional, Flores, Katia, additional, Font, Carme, additional, Font, Llorenç, additional, Francisco, Iria, additional, Gabara, Cristina, additional, Galeano‐Valle, Francisco, additional, Galindo, David, additional, García, María Angelina, additional, García‐Bragado, Ferrán, additional, García de Herreros, Marta, additional, García‐Hernáez, Raquel, additional, García‐Mullor, María Mar, additional, García‐Raso, Arantxa, additional, Gavín‐Sebastián, Olga, additional, Gil‐Díaz, Aida, additional, Gómez‐Cuervo, Covadonga, additional, Grau, Enric, additional, Guirado, Leticia, additional, Gutiérrez, Javier, additional, Hernández‐Blasco, Luis, additional, Hernando, Elena, additional, Herreros, Miguel, additional, Jara‐Palomares, Luis, additional, Jaras, María Jesús, additional, Jiménez, Rafael, additional, Joya, Maria Dolores, additional, León, José Manuel, additional, Lima, Jorge, additional, Llamas, Pilar, additional, Lobo, José Luis, additional, López‐Jiménez, Luciano, additional, López‐Miguel, Patricia, additional, López‐Núñez, Juan José, additional, López‐Reyes, Raquel, additional, López‐Ruiz, Antonio, additional, López‐Sáez, Juan Bosco, additional, Lorenzo, Alicia, additional, Madridano, Olga, additional, Maestre, Ana, additional, Marchena, Pablo Javier, additional, Martín del Pozo, Mar, additional, Martín‐Martos, Francisco, additional, Mella, Carmen, additional, Mellado, Meritxell, additional, Mercado, Maria Isabel, additional, Moisés, Jorge, additional, del Valle Morales, María, additional, Muñoz‐Blanco, Arturo, additional, Muñoz‐Rivas, Nuria, additional, Navas, María Sierra, additional, Nieto, Jose Antonio, additional, Núñez‐Fernández, Manuel Jesús, additional, Obispo, Berta, additional, Olid, Mónica, additional, Olivares, María Carmen, additional, Orcastegui, José Luis, additional, Ortega‐Michel, Clara, additional, Osorio, Jeisson, additional, Otalora, Sonia, additional, Parra, Pedro, additional, Parra, Virginia, additional, Pedrajas, José María, additional, Pellejero, Galadriel, additional, Porras, José Antonio, additional, Portillo, José, additional, Riera‐Mestre, Antoni, additional, Rivera‐Civico, Francisco, additional, Rodríguez‐Chiaradía, Diego Agustín, additional, Rodríguez‐Cobo, Ana, additional, Rodríguez‐Matute, Consolación, additional, Rogado, Jacobo, additional, Roig, Sonia, additional, Rosa, Vladimir, additional, Ruiz‐Artacho, Pedro, additional, Ruiz‐Giménez, Nuria, additional, Ruiz‐Ruiz, Justo, additional, Ruiz‐Sada, Pablo, additional, Salgueiro, Giorgina, additional, Sánchez‐Martínez, Rosario, additional, Sánchez‐Muñoz‐Torrero, Juan Francisco, additional, Sancho, Teresa, additional, Sirisi, Merçe, additional, Soler, Silvia, additional, Tirado, Raimundo, additional, Torres, María Isabel, additional, Tolosa, Carles, additional, Trujillo‐Santos, Javier, additional, Uresandi, Fernando, additional, Valero, Beatriz, additional, Valle, Reina, additional, Vela, Jerónimo Ramón, additional, Vidal, Gemma, additional, Villares, Paula, additional, Zamora, Carles, additional, Gutiérrez, Paula, additional, Vázquez, Fernando Javier, additional, Engelen, Matthias, additional, Vanassche, Thomas, additional, Hirmerova, Jana, additional, Salgado, Estuardo, additional, Ait Abdallah, Nassim, additional, Bura‐Riviere, Alessandra, additional, Crichi, Benjamin, additional, Debourdeau, Philippe, additional, Olivier, Espitia, additional, Falvo, Nicolas, additional, Galliazzo, Silvia, additional, Helfer, Hélène, additional, Mahé, Isabelle, additional, Moustafa, Farès, additional, Poenou, Geraldine, additional, Braester, Andrei, additional, Bilora, Franca, additional, Bucherini, Eugenio, additional, Ciammaichella, Maurizio, additional, Imbalzano, Egidio, additional, Maida, Rosa, additional, Mastroiacovo, Daniela, additional, Pace, Federica, additional, Pesavento, Raffaele, additional, Pomero, Fulvio, additional, Quintavalla, Roberto, additional, Rocci, Anna, additional, Romualdi, Roberta, additional, Tufano, Antonella, additional, Visonà, Adriana, additional, Zalunardo, Beniamino, additional, Gibietis, Valdis, additional, Kigitovica, Dana, additional, Skride, Andris, additional, Fonseca, Samuel, additional, Martins, Filipa, additional, Meireles, Jose, additional, Mazzolai, Lucia, additional, Bikdeli, Behnood, additional, Tafur, Alfonso J., additional, Ochoa‐Chaar, Cassius Iyad, additional, Weinberg, Ido, additional, and Wilkins, Hannah, additional

Published
2021
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49. Inflammatory Biomarkers in the Short-Term Prognosis of Venous Thromboembolism: A Narrative Review

Author

Galeano Valle, Francisco, Ordieres Ortega, Lucía, Oblitas, Crhistian Mario, Toro Cervera, Jorge del, Álvarez-Sala Walther, Luis Antonio, Demelo Rodríguez, Pablo, Galeano Valle, Francisco, Ordieres Ortega, Lucía, Oblitas, Crhistian Mario, Toro Cervera, Jorge del, Álvarez-Sala Walther, Luis Antonio, and Demelo Rodríguez, Pablo

Abstract

The relationship between inflammation and venous thrombosis is not well understood. An inflammatory response may be both the cause and consequence of venous thromboembolism (VTE). In fact, several risk factors of VTE modulate thrombosis through inflammatory markers. Acute pulmonary embolism (PE) is burdened by a remarkable mortality rate, up to 34% in severely ill patients presenting with hemodynamic instability. Initial mortality risk stratification is based on hemodynamic instability. Patients with a situation of hemodynamic stability require immediate further risk assessment based on clinical, imaging, and circulating biomarkers, as well as the presence of comorbidities. Some inflammatory biomarkers have shown potential usefulness in the risk stratification of patients with VTE, especially acute PE. C-reactive protein on admission is associated with 30-day mortality and bleeding in VTE patients. P-selectin is associated with right ventricle dysfunction in PE patients and might be associated with VTE recurrences and the extension of thrombosis. Tissue factor microparticles are associated with VTE recurrence in cancer-associated thrombosis. Other inflammatory biomarkers present scarce evidence (inflammatory cytokines, erythrocyte sedimentation rate, fibrinogen, leukocyte count). In this manuscript, we will review the prognostic role of different inflammatory biomarkers available both for clinical practice and research in VTE patients., Depto. de Medicina, Fac. de Medicina, TRUE, pub

Published
2021

50. Mid-Regional Pro-Adrenomedullin, Methemoglobin and Carboxyhemoglobin as Prognosis Biomarkers in Critically Ill Patients with COVID-19: An Observational Prospective Study

Author

Oblitas, Crhistian Mario, Galeano Valle, Francisco, Ramírez Navarro, Jesús, López Cano, Jorge, Monterrubio Manrique, Ángel, García Gámiz, Mercedes, Sancho González, Milagros, Arenal López, Sara, Álvarez Sala Walther, Luis Antonio, Demelo Rodríguez, Pablo, Oblitas, Crhistian Mario, Galeano Valle, Francisco, Ramírez Navarro, Jesús, López Cano, Jorge, Monterrubio Manrique, Ángel, García Gámiz, Mercedes, Sancho González, Milagros, Arenal López, Sara, Álvarez Sala Walther, Luis Antonio, and Demelo Rodríguez, Pablo

Abstract

Depto. de Medicina, Fac. de Medicina, TRUE, pub

Published
2021

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